# Adenoma hipofisário silencioso

> Página oficial: https://raras.org/doenca/adenoma-hipofisario-silencioso
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 314786 — https://www.orpha.net/en/disease/detail/314786
- **CID-10**: D35.2
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Adenoma hipofisário silencioso é um tumor benigno da hipófise que não produz hormônios em excesso, sendo frequentemente descoberto incidentalmente. Pode causar sintomas por compressão de estruturas vizinhas ou, raramente, por deficiência hormonal.

## Epidemiologia e herança


## Genes associados (2)

- **MEN1** — Menin [Major susceptibility factor in]
  - Função: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the T
- **AIP** — Small ribosomal subunit protein bS22, mitochondrial [Major susceptibility factor in]
  - Função: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

## Ensaios clínicos ativos (3)

- **NCT06163261** [RECRUITING]: Individualized Physical Activity or Patients With Non Functioning Pituitary Adenoma — https://clinicaltrials.gov/study/NCT06163261
- **NCT06297473** [ENROLLING_BY_INVITATION]: Physical Attendance Versus Telephone or Video Follow-up in Patients With Non-functioning Pituitary Tumors. — https://clinicaltrials.gov/study/NCT06297473
- **NCT07034859** [ENROLLING_BY_INVITATION]: Cabergoline in the Management of Nonfunctioning Pituitary Adenoma — https://clinicaltrials.gov/study/NCT07034859
- **NCT04218721** [COMPLETED]: Implementing eHealth Interventions Into Regular Clinical Practice — https://clinicaltrials.gov/study/NCT04218721
- **NCT05005715** [UNKNOWN]: Effect of Dexmedetomidine on Quality of Recovery in Non-functioning Pituitary Adenoma Patients Undergoing Endoscopic Transsphenoidal Surgery — https://clinicaltrials.gov/study/NCT05005715
- **NCT04335357** [UNKNOWN]: TBR-760 in Adult Patients With Non-Functioning Pituitary Adenomas — https://clinicaltrials.gov/study/NCT04335357
- **NCT01283542** [COMPLETED]: Evaluate the Efficacy and Safety of Pasireotide LAR (Long Acting Release) on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma. — https://clinicaltrials.gov/study/NCT01283542
- **NCT03714763** [UNKNOWN]: Dopamine D2 Receptors(D2R) Imaging in Nonfunctioning Pituitary Adenoma(NFPA) — https://clinicaltrials.gov/study/NCT03714763
- **NCT03271918** [COMPLETED]: Cabergoline in Nonfunctioning Pituitary Adenomas — https://clinicaltrials.gov/study/NCT03271918
- **NCT01203618** [WITHDRAWN]: Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas — https://clinicaltrials.gov/study/NCT01203618

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Adenoma hipofisário silencioso. Disponível em: https://raras.org/doenca/adenoma-hipofisario-silencioso
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