# Carcinoma do plexo coroide

> Página oficial: https://raras.org/doenca/carcinoma-do-plexo-coroide
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 251899 — https://www.orpha.net/en/disease/detail/251899
- **CID-10**: C71.7
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

É um tipo de câncer agressivo que nasce no plexo coroide, uma estrutura que existe dentro do cérebro. As células desse tumor são muito alteradas e crescem rapidamente, demonstrando grande agressividade. Geralmente, ele invade as estruturas cerebrais próximas. É comum que o câncer se espalhe para outras áreas através do líquido cefalorraquidiano (o líquor), que envolve o cérebro e a medula espinhal.

## Epidemiologia e herança

- **Prevalência**: 1-9 / 1 000 000
- **Padrão de herança**: Autosomal dominant

## Genes associados (1)

- **TP53** — Cellular tumor antigen p53 [Disease-causing germline mutation(s) in]
  - Função: Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775

## Ensaios clínicos ativos (4)

- **NCT04185038** [RECRUITING]: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors — https://clinicaltrials.gov/study/NCT04185038
- **NCT03050268** [RECRUITING]: Familial Investigations of Childhood Cancer Predisposition — https://clinicaltrials.gov/study/NCT03050268
- **NCT03500991** [ACTIVE_NOT_RECRUITING]: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors — https://clinicaltrials.gov/study/NCT03500991
- **NCT06357377** [NOT_YET_RECRUITING]: A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors — https://clinicaltrials.gov/study/NCT06357377
- **NCT04994977** [TERMINATED]: Intra-Arterial Chemotherapy for Newly Diagnosed, Residual, or Recurrent Atypical Choroid Plexus Papilloma and Choroid Plexus Carcinoma Prior to Second-Look Surgery — https://clinicaltrials.gov/study/NCT04994977
- **NCT03638167** [COMPLETED]: EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors — https://clinicaltrials.gov/study/NCT03638167
- **NCT05934630** [SUSPENDED]: Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors — https://clinicaltrials.gov/study/NCT05934630
- **NCT04521946** [WITHDRAWN]: Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer — https://clinicaltrials.gov/study/NCT04521946
- **NCT03434262** [COMPLETED]: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors — https://clinicaltrials.gov/study/NCT03434262

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Carcinoma do plexo coroide. Disponível em: https://raras.org/doenca/carcinoma-do-plexo-coroide
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