# Chikungunya

> Página oficial: https://raras.org/doenca/chikungunya
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 324625 — https://www.orpha.net/en/disease/detail/324625
- **CID-10**: A92.0
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Infecção causada pelo vírus Chikungunya, transmitido por mosquitos; é caracterizada por febre e artralgia grave.

## Epidemiologia e herança

- **Prevalência**: Unknown
- **Padrão de herança**: Not applicable

## Sinais e sintomas (51 fenótipos HPO)

- **Bursite** — HPO: HP:0025232 (Ocasional (29-5%))
- **Artrite** — HPO: HP:0001369 (Frequente (79-30%))
- **Edema facial** — HPO: HP:0000282 (Ocasional (29-5%))
- **Vômitos** — HPO: HP:0002013 (Ocasional (29-5%))
- **Fotofobia** — HPO: HP:0000613 (Ocasional (29-5%))
- **Linfadenopatia** — HPO: HP:0002716 (Raro (<5%))
- **Sangramento anormal** — HPO: HP:0001892 (Ocasional (29-5%))
- **Prurido** — HPO: HP:0000989 (Ocasional (29-5%))
- **Fotossensibilidade cutânea** — HPO: HP:0000992 (Ocasional (29-5%))
- **Motivação diminuída** — HPO: HP:0000745 (Frequente (79-30%))
- **Febre** — HPO: HP:0001945 (Muito frequente (99-80%))
- **Erupção cutânea** — HPO: HP:0000988 (Frequente (79-30%))
- **Cefaleia** — HPO: HP:0002315 (Frequente (79-30%))
- **Sangramento gengival** — HPO: HP:0000225 (Ocasional (29-5%))
- **Osteólise** — HPO: HP:0002797 (Raro (<5%))
- **Convulsão** — HPO: HP:0001250 (Raro (<5%))
- **Inchaço articular** — HPO: HP:0001386 (Frequente (79-30%))
- **Diarreia** — HPO: HP:0002014 (Ocasional (29-5%))
- **Petéquias** — HPO: HP:0000967 (Ocasional (29-5%))
- **Artralgia** — HPO: HP:0002829 (Muito frequente (99-80%))
- **Depressão** — HPO: HP:0000716 (Ocasional (29-5%))
- **Encefalite infecciosa** — HPO: HP:0002383 (Raro (<5%))
- **Epistaxe** — HPO: HP:0000421 (Ocasional (29-5%))
- **Rigidez articular** — HPO: HP:0001387 (Frequente (79-30%))
- **Mácula** — HPO: HP:0012733 (Frequente (79-30%))
- **Neuropatia mediana constritiva** — HPO: HP:0012185 (Raro (<5%))
- **Neurite** — HPO: HP:0031002 (Raro (<5%))
- **Periostite** — HPO: HP:0040165 (Ocasional (29-5%))
- **Edema pedal** — HPO: HP:0010741 (Frequente (79-30%))
- **Bolhas anormais na pele** — HPO: HP:0008066 (Ocasional (29-5%))
- **Dor no joelho** — HPO: HP:0030839 (Frequente (79-30%))
- **Mialgia** — HPO: HP:0003326 (Frequente (79-30%))
- **Neuropatia periférica** — HPO: HP:0009830 (Ocasional (29-5%))
- **Despigmentação/hiperpigmentação da pele** — HPO: HP:0007483 (Frequente (79-30%))
- **Vesícula cutânea** — HPO: HP:0200037 (Ocasional (29-5%))
- **Fadiga** — HPO: HP:0012378 (Muito frequente (99-80%))
- **Olho vermelho** — HPO: HP:0025337 (Ocasional (29-5%))
- **Linfadenopatia cervical** — HPO: HP:0025289 (Ocasional (29-5%))
- **Derrame articular do tornozelo** — HPO: HP:0032063 (Ocasional (29-5%))
- **Entesite** — HPO: HP:0100686 (Ocasional (29-5%))
- _...e mais 11 sintomas. Ver https://raras.org/doenca/chikungunya._

## Ensaios clínicos ativos (21)

- **NCT07003984** [RECRUITING]: A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children. — https://clinicaltrials.gov/study/NCT07003984
- **NCT07358910** [RECRUITING]: Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective — https://clinicaltrials.gov/study/NCT07358910
- **NCT07120724** [RECRUITING]: Real-World Study on Chinese Medicine for Treating Chikungunya Fever — https://clinicaltrials.gov/study/NCT07120724
- **NCT06928753** [RECRUITING]: Real-world Effectiveness, Safety and Immunogenicity of Chikungunya Vaccination in Populations at Risk of Severe or Complicated Forms: Prospective Study in La Réunion — https://clinicaltrials.gov/study/NCT06928753
- **NCT04615364** [RECRUITING]: Genetic Evolution of Arboviruses in New Caledonia Between 1995 and 2024 and Impact of Wolbachia — https://clinicaltrials.gov/study/NCT04615364
- **NCT04619823** [RECRUITING]: Virological and Immunological Determinants of Arbovirus Infection in New Caledonia — https://clinicaltrials.gov/study/NCT04619823
- **NCT07520279** [ENROLLING_BY_INVITATION]: Xpert® Tropical Fever Test on GeneXpert® Edge X System — https://clinicaltrials.gov/study/NCT07520279
- **NCT07254702** [ENROLLING_BY_INVITATION]: Prospective Safety Cohort Study After VLA1553 Vaccination in Municipalities Selected for Participation in the VLA1553 Pilot Vaccination Strategy in Brazil — https://clinicaltrials.gov/study/NCT07254702
- **NCT07347002** [ENROLLING_BY_INVITATION]: Observational Study to Assess the Effectiveness of VLA1553 Vaccine in Preventing Chikungunya During a Pilot Vaccination Strategy in Brazil — https://clinicaltrials.gov/study/NCT07347002
- **NCT07163845** [ACTIVE_NOT_RECRUITING]: Assessment of Chikungunya Virus Seroprevalence Before VLA1553 Vaccination in the Municipalities Selected for Participation in the VLA1553 Pilot Vaccination Strategy in Brazil — https://clinicaltrials.gov/study/NCT07163845

## Doenças relacionadas (por similaridade fenotípica)

- [Lúpus eritematoso sistêmico](https://raras.org/doenca/lupus-eritematoso-sistemico) — ORPHA:536 — 19 sintomas em comum
- [Dermatose tóxica](https://raras.org/doenca/dermatose-toxica) — ORPHA:293815 — 19 sintomas em comum
- [Doença sobreposta do tecido conjuntivo](https://raras.org/doenca/doenca-sobreposta-do-tecido-conjuntivo) — ORPHA:251312 — 16 sintomas em comum
- [Vasculite mediada por complexos imunes](https://raras.org/doenca/vasculite-mediada-por-complexos-imunes) — ORPHA:156149 — 16 sintomas em comum
- [Doença mista do tecido conjuntivo](https://raras.org/doenca/doenca-mista-do-tecido-conjuntivo) — ORPHA:809 — 16 sintomas em comum
- [Doença de Behçet](https://raras.org/doenca/doenca-de-behcet) — ORPHA:117 — 16 sintomas em comum
- [Riquetsiose](https://raras.org/doenca/riquetsiose) — ORPHA:102021 — 15 sintomas em comum
- [Complicação após transplante de órgão](https://raras.org/doenca/complicacao-apos-transplante-de-orgao) — ORPHA:306644 — 15 sintomas em comum
- [Mastocitose](https://raras.org/doenca/mastocitose) — ORPHA:98292 — 15 sintomas em comum
- [Porfiria hepática](https://raras.org/doenca/porfiria-hepatica) — ORPHA:659694 — 14 sintomas em comum

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Chikungunya. Disponível em: https://raras.org/doenca/chikungunya
**Formato HTML**: https://raras.org/doenca/chikungunya
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=324625