# Doença Castleman multicêntrica HHV-8 associada

> Página oficial: https://raras.org/doenca/doenca-castleman-multicentrica-hhv-8-associada
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 570438 — https://www.orpha.net/en/disease/detail/570438
- **CID-10**: D47.7

## Descrição clínica

Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.

## Epidemiologia e herança

- **Prevalência**: Unknown

## Ensaios clínicos ativos (2)

- **NCT06052618** [RECRUITING]: Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS) — https://clinicaltrials.gov/study/NCT06052618
- **NCT04742387** [ACTIVE_NOT_RECRUITING]: Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis — https://clinicaltrials.gov/study/NCT04742387
- **NCT03864419** [TERMINATED]: Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda — https://clinicaltrials.gov/study/NCT03864419
- **NCT01441063** [COMPLETED]: Tocilizumab for KSHV-Associated Multicentric Castleman Disease — https://clinicaltrials.gov/study/NCT01441063
- **NCT02228512** [WITHDRAWN]: Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas — https://clinicaltrials.gov/study/NCT02228512

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Doença Castleman multicêntrica HHV-8 associada. Disponível em: https://raras.org/doenca/doenca-castleman-multicentrica-hhv-8-associada
**Formato HTML**: https://raras.org/doenca/doenca-castleman-multicentrica-hhv-8-associada
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=570438