# Fechamento prematuro do canal arterial

> Página oficial: https://raras.org/doenca/fechamento-prematuro-do-canal-arterial
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 95486 — https://www.orpha.net/en/disease/detail/95486
- **CID-10**: Q25.8

## Descrição clínica

Premature closure of the arterial duct is a rare arterial duct anomaly, defined as a significant constriction or closure of the fetal arterial duct in the absence of structural heart defects with pathognomonic features of increased right ventricular afterload, tricuspid regurgitation and, consequently, right atrial dilation and right ventricular hypertrophy. The severity of symptoms is related to the degree and rate of ductal constriction and ranges from mild postnatal respiratory distress to development of ventricular failure with fetal hydrops and intrauterine death or severe cardiopulmonary compromise in the postnatal period. It may be associated with a prenatal exposure to cyclooxygenase inhibitors or corticosteroids.

## Epidemiologia e herança


## Ensaios clínicos ativos (5)

- **NCT06627374** [RECRUITING]: Study of Thoracic Ultrasound As a Response to the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants — https://clinicaltrials.gov/study/NCT06627374
- **NCT04508036** [UNKNOWN]: Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels — https://clinicaltrials.gov/study/NCT04508036
- **NCT03701074** [TERMINATED]: Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus — https://clinicaltrials.gov/study/NCT03701074
- **NCT04126512** [COMPLETED]: Timing of Surgical PDA Ligation and Neonatal Outcomes — https://clinicaltrials.gov/study/NCT04126512
- **NCT03008876** [COMPLETED]: IV Acetaminophen and Patent Ductus Arteriosus — https://clinicaltrials.gov/study/NCT03008876

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Fechamento prematuro do canal arterial. Disponível em: https://raras.org/doenca/fechamento-prematuro-do-canal-arterial
**Formato HTML**: https://raras.org/doenca/fechamento-prematuro-do-canal-arterial
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=95486