# Ganglioneuroblastoma

> Página oficial: https://raras.org/doenca/ganglioneuroblastoma
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 251877 — https://www.orpha.net/en/disease/detail/251877
- **CID-10**: C71.9
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Tumor neuroblástico caracterizado pela presença de células neuroblásticas, células ganglionares e um estroma com diferenciação Schwanniana constituindo mais de cinquenta por cento do volume do tumor. Existem dois subtipos histológicos identificados: ganglioneuroblastoma misto e ganglioneuroblastoma nodular.

## Epidemiologia e herança

- **Prevalência**: <1 / 1 000 000
- **Casos conhecidos**: 425
- **Padrão de herança**: Not applicable

## Genes associados (1)

- **ALK** — ALK tyrosine kinase receptor [Major susceptibility factor in]
  - Função: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differe

## Ensaios clínicos ativos (17)

- **NCT06172296** [RECRUITING]: Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma — https://clinicaltrials.gov/study/NCT06172296
- **NCT07502287** [RECRUITING]: Dual-Target GD2/B7-H3 CAR-NK Cells for Pediatric Relapsed or Refractory Neuroblastoma — https://clinicaltrials.gov/study/NCT07502287
- **NCT03126916** [RECRUITING]: Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) — https://clinicaltrials.gov/study/NCT03126916
- **NCT07375563** [RECRUITING]: Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and Ganglioneuroblastoma — https://clinicaltrials.gov/study/NCT07375563
- **NCT02112617** [RECRUITING]: Phase II Study of Proton Radiation Therapy for Neuroblastoma — https://clinicaltrials.gov/study/NCT02112617
- **NCT05192980** [RECRUITING]: SIOPEN BIOPORTAL, An International Registry Linked to a Virtual Biobank for Patients With Peripheral Neuroblastic Tumours — https://clinicaltrials.gov/study/NCT05192980
- **NCT06296732** [RECRUITING]: Abdominal Neuroblastoma Laparoscopic Surgery Risk Factors Stratification — https://clinicaltrials.gov/study/NCT06296732
- **NCT06071897** [RECRUITING]: Induction Chemoimmunotherapy for Patients With High-risk Neuroblastoma — https://clinicaltrials.gov/study/NCT06071897
- **NCT03786783** [ACTIVE_NOT_RECRUITING]: Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma — https://clinicaltrials.gov/study/NCT03786783
- **NCT04040088** [ACTIVE_NOT_RECRUITING]: An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors — https://clinicaltrials.gov/study/NCT04040088

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Ganglioneuroblastoma. Disponível em: https://raras.org/doenca/ganglioneuroblastoma
**Formato HTML**: https://raras.org/doenca/ganglioneuroblastoma
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=251877