# Germinoma do cérebro

> Página oficial: https://raras.org/doenca/germinoma-do-cerebro
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 91352 — https://www.orpha.net/en/disease/detail/91352
- **CID-10**: C72.9
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Um germinoma que surge da glândula pineal.

## Epidemiologia e herança


## Genes associados (1)

- **JMJD1C** — Jumonji domain-containing protein 1C [Major susceptibility factor in]
  - Função: Demethylates lysine in proteins, such as STAT3 or MDC1 (By similarity) (PubMed:24240613). Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination

## Ensaios clínicos ativos (4)

- **NCT06368817** [RECRUITING]: A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma — https://clinicaltrials.gov/study/NCT06368817
- **NCT05564026** [RECRUITING]: Molecular Epidemiology of Pediatric Germ Cell Tumors — https://clinicaltrials.gov/study/NCT05564026
- **NCT04648462** [RECRUITING]: Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology — https://clinicaltrials.gov/study/NCT04648462
- **NCT02375204** [ACTIVE_NOT_RECRUITING]: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors — https://clinicaltrials.gov/study/NCT02375204
- **NCT01445288** [COMPLETED]: Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors — https://clinicaltrials.gov/study/NCT01445288
- **NCT01602666** [COMPLETED]: Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors — https://clinicaltrials.gov/study/NCT01602666
- **NCT00788125** [TERMINATED]: Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors — https://clinicaltrials.gov/study/NCT00788125
- **NCT01346267** [COMPLETED]: Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy — https://clinicaltrials.gov/study/NCT01346267
- **NCT00085098** [COMPLETED]: Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor — https://clinicaltrials.gov/study/NCT00085098
- **NCT00047320** [COMPLETED]: Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors — https://clinicaltrials.gov/study/NCT00047320

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Germinoma do cérebro. Disponível em: https://raras.org/doenca/germinoma-do-cerebro
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**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=91352