# Hipertrofia do membro inferior

> Página oficial: https://raras.org/doenca/hipertrofia-do-membro-inferior
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 295051 — https://www.orpha.net/en/disease/detail/295051
- **CID-10**: Q74.2

## Descrição clínica

Lower limb hypertrophy is a rare, genetic, non-syndromic developmental defect during embryogenesis characterized by uni- or bilateral overgrowth of lower limbs involving bones and/or soft tissues and resulting in an abnormal increase in leg length and/or width. Hypertrophy presents either as a proportionate overgrowth of entire limb or involves only the proximal or distal parts of it. Phenotype ranges from mild hypertrophy without functional disability to massively hypertrophied limb with knee flexion and ankle equinus contractures and macrodystrophia lipomatosa. Patients may also present vascular abnormalities (e.g. cutaneous angiomas, varicose veins) and myalgia.

## Epidemiologia e herança


## Ensaios clínicos ativos (5)

- **NCT07155967** [ENROLLING_BY_INVITATION]: Effect of Cross-Education in Blood Flow Restriction Resistance Training on Lower Limbs in Older Women — https://clinicaltrials.gov/study/NCT07155967
- **NCT06350591** [COMPLETED]: Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse — https://clinicaltrials.gov/study/NCT06350591
- **NCT06912867** [COMPLETED]: Effects of BFR Training on Muscle Strength, Thickness, and Motivation in National Adolescent Male Canoe Athletes — https://clinicaltrials.gov/study/NCT06912867
- **NCT02924402** [COMPLETED]: Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic Malignancies — https://clinicaltrials.gov/study/NCT02924402
- **NCT03983070** [COMPLETED]: The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size. — https://clinicaltrials.gov/study/NCT03983070

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Hipertrofia do membro inferior. Disponível em: https://raras.org/doenca/hipertrofia-do-membro-inferior
**Formato HTML**: https://raras.org/doenca/hipertrofia-do-membro-inferior
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=295051