# Leucemia aguda de fenótipo misto com t(v;11q23.3)

> Página oficial: https://raras.org/doenca/leucemia-aguda-de-fenotipo-misto-com-tv11q233
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 589595 — https://www.orpha.net/en/disease/detail/589595
- **CID-10**: C92.6
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Leucemia aguda rara com características de linhagens mieloides e linfoides, associada à translocação t(v;11q23.3) que afeta os genes KMT2A e AFF1. Frequentemente apresenta mutações no gene FLT3.

## Epidemiologia e herança

- **Prevalência**: Unknown
- **Padrão de herança**: Not applicable

## Genes associados (3)

- **FLT3** — Receptor-type tyrosine-protein kinase FLT3 [Disease-causing somatic mutation(s) in]
  - Função: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.
- **KMT2A** — Histone-lysine N-methyltransferase 2A [Part of a fusion gene in]
  - Função: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, Pub
- **AFF1** — AF4/FMR2 family member 1 [Part of a fusion gene in]

## Ensaios clínicos ativos (5)

- **NCT05602194** [RECRUITING]: Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma — https://clinicaltrials.gov/study/NCT05602194
- **NCT04128501** [ACTIVE_NOT_RECRUITING]: Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting — https://clinicaltrials.gov/study/NCT04128501
- **NCT05316701** [ACTIVE_NOT_RECRUITING]: Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies — https://clinicaltrials.gov/study/NCT05316701
- **NCT04195633** [RECRUITING]: Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies — https://clinicaltrials.gov/study/NCT04195633
- **NCT06390319** [RECRUITING]: Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL) — https://clinicaltrials.gov/study/NCT06390319

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Leucemia aguda de fenótipo misto com t(v;11q23.3). Disponível em: https://raras.org/doenca/leucemia-aguda-de-fenotipo-misto-com-tv11q233
**Formato HTML**: https://raras.org/doenca/leucemia-aguda-de-fenotipo-misto-com-tv11q233
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=589595