# Lúpus eritematoso discoide

> Página oficial: https://raras.org/doenca/lupus-eritematoso-discoide
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-08

## Identificadores

- **ORPHA**: 90281 — https://www.orpha.net/en/disease/detail/90281
- **CID-10**: L93.0
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Doença crônica e autoimune da pele que se manifesta com erupção cutânea vermelha e descamativa, mais frequentemente encontrada no rosto, orelhas e couro cabeludo; essas lesões geralmente levam a cicatrizes permanentes e despigmentação. Os pacientes podem apresentar lesões com ou sem outros sintomas ou anticorpos sugestivos de lúpus eritematoso sistêmico (LES).

## Epidemiologia e herança

- **Prevalência**: 1-5 / 10 000

## Sinais e sintomas (10 fenótipos HPO)

- **Placa eritematosa** — HPO: HP:0025474 (Frequente (79-30%))
- **Teste de banda lúpica positivo** — HPO: HP:4000107 (Frequente (79-30%))
- **Hipopigmentação da pele** — HPO: HP:0001010 (Frequente (79-30%))
- **Alopecia cicatricial do couro cabeludo** — HPO: HP:0004552 (Frequente (79-30%))
- **Artralgia** — HPO: HP:0002829 (Ocasional (29-5%))
- **Telangiectasia da pele** — HPO: HP:0100585 (Frequente (79-30%))
- **Hiperceratose folicular** — HPO: HP:0007502 (Frequente (79-30%))
- **Carcinoma de células escamosas da pele** — HPO: HP:0006739 (Raro (<5%))
- **Pápula eritematosa** — HPO: HP:0030350 (Frequente (79-30%))
- **Cicatrizes atróficas** — HPO: HP:0001075 (Frequente (79-30%))

## Ensaios clínicos ativos (10)

- **NCT06980805** [RECRUITING]: A Study to Assess the Safety, Tolerability, and Efficacy of IMVT-1402 in Participants With Cutaneous Lupus Erythematosus (CLE) — https://clinicaltrials.gov/study/NCT06980805
- **NCT07332481** [RECRUITING]: A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease — https://clinicaltrials.gov/study/NCT07332481
- **NCT07355218** [RECRUITING]: A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) — https://clinicaltrials.gov/study/NCT07355218
- **NCT05531565** [RECRUITING]: A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus — https://clinicaltrials.gov/study/NCT05531565
- **NCT06013995** [RECRUITING]: A Study to Investigate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986326 in Adult Participants With Different Forms of Lupus — https://clinicaltrials.gov/study/NCT06013995
- **NCT06015737** [RECRUITING]: A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus — https://clinicaltrials.gov/study/NCT06015737
- **NCT06261021** [RECRUITING]: Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus — https://clinicaltrials.gov/study/NCT06261021
- **NCT06044337** [ENROLLING_BY_INVITATION]: A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus — https://clinicaltrials.gov/study/NCT06044337
- **NCT05540327** [ACTIVE_NOT_RECRUITING]: The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE) — https://clinicaltrials.gov/study/NCT05540327
- **NCT04857034** [ACTIVE_NOT_RECRUITING]: A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) — https://clinicaltrials.gov/study/NCT04857034

## Doenças relacionadas (por similaridade fenotípica)

- [Lúpus eritematoso cutâneo crônico](https://raras.org/doenca/lupus-eritematoso-cutaneo-cronico) — ORPHA:163531 — 10 sintomas em comum
- [Xeroderma pigmentoso](https://raras.org/doenca/xeroderma-pigmentoso) — ORPHA:910 — 5 sintomas em comum
- [Queratose pilaris atrófica](https://raras.org/doenca/498) — ORPHA:498 — 4 sintomas em comum
- [Mastocitose](https://raras.org/doenca/mastocitose) — ORPHA:98292 — 3 sintomas em comum
- [Distrofia muscular Bethlem](https://raras.org/doenca/distrofia-muscular-bethlem) — ORPHA:610 — 3 sintomas em comum
- [Vasculopatia livedoide](https://raras.org/doenca/vasculopatia-livedoide) — ORPHA:542643 — 3 sintomas em comum
- [Epidermólise bolhosa generalizada simples autossômica dominante, forma grave](https://raras.org/doenca/epidermolise-bolhosa-generalizada-simples-autossomica-dominante-forma-grave) — ORPHA:79396 — 3 sintomas em comum
- [Esclerodermia](https://raras.org/doenca/esclerodermia) — ORPHA:801 — 3 sintomas em comum
- [Síndrome Sweet](https://raras.org/doenca/sindrome-sweet) — ORPHA:3243 — 3 sintomas em comum
- [Epidermólise bolhosa distrófica](https://raras.org/doenca/303) — ORPHA:303 — 3 sintomas em comum

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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