# Melanoma primário do sistema nervoso central

> Página oficial: https://raras.org/doenca/melanoma-primario-do-sistema-nervoso-central
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 252050 — https://www.orpha.net/en/disease/detail/252050
- **CID-10**: C70.9

## Descrição clínica

A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor.

## Epidemiologia e herança

- **Prevalência**: <1 / 1 000 000

## Ensaios clínicos ativos (5)

- **NCT02858869** [COMPLETED]: Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases — https://clinicaltrials.gov/study/NCT02858869
- **NCT02568267** [ACTIVE_NOT_RECRUITING]: Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) — https://clinicaltrials.gov/study/NCT02568267
- **NCT04771520** [RECRUITING]: Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors — https://clinicaltrials.gov/study/NCT04771520
- **NCT05969860** [RECRUITING]: At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer — https://clinicaltrials.gov/study/NCT05969860
- **NCT02713269** [ACTIVE_NOT_RECRUITING]: Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord — https://clinicaltrials.gov/study/NCT02713269

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Melanoma primário do sistema nervoso central. Disponível em: https://raras.org/doenca/melanoma-primario-do-sistema-nervoso-central
**Formato HTML**: https://raras.org/doenca/melanoma-primario-do-sistema-nervoso-central
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=252050