# Oligoastrocitoma

> Página oficial: https://raras.org/doenca/oligoastrocitoma
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 251656 — https://www.orpha.net/en/disease/detail/251656
- **CID-10**: C71.9
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Tumor grau II da OMS composto por uma mistura notável de dois tipos distintos de células neoplásicas que se assemelham morfologicamente às células tumorais do oligodendroglioma e do astrocitoma difuso. (QUEM)

## Epidemiologia e herança


## Genes associados (1)

- **IDH2** — Isocitrate dehydrogenase [NADP], mitochondrial [Biomarker tested in]
  - Função: Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:

## Ensaios clínicos ativos (6)

- **NCT02800486** [RECRUITING]: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA — https://clinicaltrials.gov/study/NCT02800486
- **NCT04623931** [RECRUITING]: Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas — https://clinicaltrials.gov/study/NCT04623931
- **NCT03152318** [ACTIVE_NOT_RECRUITING]: A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 — https://clinicaltrials.gov/study/NCT03152318
- **NCT07031765** [ACTIVE_NOT_RECRUITING]: Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma — https://clinicaltrials.gov/study/NCT07031765
- **NCT02192359** [ACTIVE_NOT_RECRUITING]: Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas — https://clinicaltrials.gov/study/NCT02192359
- **NCT03180502** [ACTIVE_NOT_RECRUITING]: Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma — https://clinicaltrials.gov/study/NCT03180502
- **NCT01849952** [TERMINATED]: Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas — https://clinicaltrials.gov/study/NCT01849952
- **NCT02026271** [COMPLETED]: A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma — https://clinicaltrials.gov/study/NCT02026271
- **NCT02549833** [COMPLETED]: Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma — https://clinicaltrials.gov/study/NCT02549833
- **NCT02530320** [COMPLETED]: Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved — https://clinicaltrials.gov/study/NCT02530320

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Oligoastrocitoma. Disponível em: https://raras.org/doenca/oligoastrocitoma
**Formato HTML**: https://raras.org/doenca/oligoastrocitoma
**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=251656