# Oligoastrocitoma anaplásico

> Página oficial: https://raras.org/doenca/oligoastrocitoma-anaplasico
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 251663 — https://www.orpha.net/en/disease/detail/251663
- **CID-10**: C71.9
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

Oligoastrocitoma caracterizado pela presença de celularidade aumentada, atipia nuclear, pleomorfismo e alta atividade mitótica.

## Epidemiologia e herança


## Genes associados (1)

- **IDH2** — Isocitrate dehydrogenase [NADP], mitochondrial [Biomarker tested in]
  - Função: Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:

## Ensaios clínicos ativos (4)

- **NCT02800486** [RECRUITING]: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA — https://clinicaltrials.gov/study/NCT02800486
- **NCT04623931** [RECRUITING]: Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas — https://clinicaltrials.gov/study/NCT04623931
- **NCT02192359** [ACTIVE_NOT_RECRUITING]: Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas — https://clinicaltrials.gov/study/NCT02192359
- **NCT03180502** [ACTIVE_NOT_RECRUITING]: Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma — https://clinicaltrials.gov/study/NCT03180502
- **NCT01849952** [TERMINATED]: Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas — https://clinicaltrials.gov/study/NCT01849952
- **NCT02026271** [COMPLETED]: A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma — https://clinicaltrials.gov/study/NCT02026271
- **NCT03043391** [COMPLETED]: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children — https://clinicaltrials.gov/study/NCT03043391
- **NCT01922076** [COMPLETED]: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas — https://clinicaltrials.gov/study/NCT01922076
- **NCT02168270** [TERMINATED]: Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma — https://clinicaltrials.gov/study/NCT02168270
- **NCT01721577** [TERMINATED]: Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas — https://clinicaltrials.gov/study/NCT01721577

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Oligoastrocitoma anaplásico. Disponível em: https://raras.org/doenca/oligoastrocitoma-anaplasico
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**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=251663