# Peste

> Página oficial: https://raras.org/doenca/peste
> Fonte: Raras.org — Banco de Dados de Doenças Raras em Português (CC BY-NC-SA 4.0)
> Última atualização: 2026-05-07

## Identificadores

- **ORPHA**: 707 — https://www.orpha.net/en/disease/detail/707
- **CID-10**: A20.0
- **OMIM**: none — https://omim.org/entry/none

## Descrição clínica

A peste é uma infecção bacteriana grave causada pela bactéria Gram-negativo <i>Yersinia pestis</i>.

## Epidemiologia e herança

- **Prevalência**: Unknown
- **Casos conhecidos**: 2

## Sinais e sintomas (55 fenótipos HPO)

- **Esplenomegalia** — HPO: HP:0001744 (Frequente (79-30%))
- **Taquicardia** — HPO: HP:0001649 (Frequente (79-30%))
- **Glossite** — HPO: HP:0000206 (Ocasional (29-5%))
- **Hepatomegalia** — HPO: HP:0002240 (Frequente (79-30%))
- **Vômitos** — HPO: HP:0002013 (Ocasional (29-5%))
- **Edema** — HPO: HP:0000969 (Ocasional (29-5%))
- **Endocardite** — HPO: HP:0100584 (Raro (<5%))
- **Bacteremia** — HPO: HP:0031864 (Frequente (79-30%))
- **Lesão cutânea localizada** — HPO: HP:0011355 (Frequente (79-30%))
- **Ileíte** — HPO: HP:0032564 (Ocasional (29-5%))
- **Meningite** — HPO: HP:0001287 (Raro (<5%))
- **Disartria** — HPO: HP:0001350 (Ocasional (29-5%))
- **Lábio rachado** — HPO: HP:0040181 (Ocasional (29-5%))
- **Artralgia** — HPO: HP:0002829 (Ocasional (29-5%))
- **Artrite** — HPO: HP:0001369 (Raro (<5%))
- **Anormalidade inflamatória do olho** — HPO: HP:0100533 (Raro (<5%))
- **Dor torácica** — HPO: HP:0100749 (Frequente (79-30%))
- **Diarreia** — HPO: HP:0002014 (Ocasional (29-5%))
- **Delírio** — HPO: HP:0031258 (Frequente (79-30%))
- **Coma** — HPO: HP:0001259 (Ocasional (29-5%))
- **Hiperemia conjuntival** — HPO: HP:0030953 (Frequente (79-30%))
- **Pneumonia infecciosa aguda** — HPO: HP:0011949 (Ocasional (29-5%))
- **Dor abdominal** — HPO: HP:0002027 (Ocasional (29-5%))
- **Midríase** — HPO: HP:0011499 (Ocasional (29-5%))
- **Sepse** — HPO: HP:0100806 (Ocasional (29-5%))
- **Eritema nodoso** — HPO: HP:0012219 (Ocasional (29-5%))
- **Ansiedade** — HPO: HP:0000739 (Frequente (79-30%))
- **Faringite** — HPO: HP:0025439 (Raro (<5%))
- **Carbúnculo** — HPO: HP:0020084 (Frequente (79-30%))
- **Pele seca** — HPO: HP:0000958 (Frequente (79-30%))
- **Sangramento anormal** — HPO: HP:0001892 (Ocasional (29-5%))
- **Cefaleia** — HPO: HP:0002315 (Frequente (79-30%))
- **Fadiga** — HPO: HP:0012378 (Muito frequente (99-80%))
- **Deficiência auditiva** — HPO: HP:0000365 (Ocasional (29-5%))
- **Enterocolite** — HPO: HP:0004387 (Ocasional (29-5%))
- **Hemoptise** — HPO: HP:0002105 (Ocasional (29-5%))
- **Fraqueza muscular** — HPO: HP:0001324 (Raro (<5%))
- **Hipotensão** — HPO: HP:0002615 (Ocasional (29-5%))
- **Anormalidade do cotovelo** — HPO: HP:0009811 (Ocasional (29-5%))
- **Linfonodo mesentérico aumentado** — HPO: HP:0025043 (Ocasional (29-5%))
- _...e mais 15 sintomas. Ver https://raras.org/doenca/peste._

## Ensaios clínicos ativos (3)

- **NCT07207408** [RECRUITING]: Immunogenicity, Safety, and Tolerability of rF1V-1018 Vaccine in Adults 18 to 55 Years of Age — https://clinicaltrials.gov/study/NCT07207408
- **NCT06943378** [RECRUITING]: Ph1, Randomized, Double-Blind and Controlled, Dose Escalation and Expansion Study to Assess the Safety and Pharmacokinetics of JST-010 in Healthy Adults — https://clinicaltrials.gov/study/NCT06943378
- **NCT07174648** [NOT_YET_RECRUITING]: Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo. — https://clinicaltrials.gov/study/NCT07174648
- **NCT05506969** [COMPLETED]: Trial of the Immunogenicity, Safety, and Tolerability of rF1V Vaccine With CpG 1018® Adjuvant Compared With rF1V Vaccine in Adults 18 to 55 Years of Age — https://clinicaltrials.gov/study/NCT05506969
- **NCT01243437** [COMPLETED]: A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans — https://clinicaltrials.gov/study/NCT01243437
- **NCT04110340** [COMPLETED]: Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague — https://clinicaltrials.gov/study/NCT04110340
- **NCT04688996** [UNKNOWN]: Yersinia Pestis Lateral Flow Immunoassay for Blood Samples — https://clinicaltrials.gov/study/NCT04688996
- **NCT05330624** [UNKNOWN]: Immunogenicity and Safety of Subunit Vaccine of Plague Vaccine With Two Immunization Regimens — https://clinicaltrials.gov/study/NCT05330624
- **NCT01122784** [COMPLETED]: Randomized Single-Blinded Study to Evaluate Safety and Immunogenicity of Recombinant Plague Vaccine With and Without Adjuvant — https://clinicaltrials.gov/study/NCT01122784
- **NCT01381744** [COMPLETED]: Dose Escalation Trial of a Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers — https://clinicaltrials.gov/study/NCT01381744

## Doenças relacionadas (por similaridade fenotípica)

- [Lúpus eritematoso sistêmico](https://raras.org/doenca/lupus-eritematoso-sistemico) — ORPHA:536 — 20 sintomas em comum
- [Encefalite infecciosa](https://raras.org/doenca/encefalite-infecciosa) — ORPHA:98252 — 18 sintomas em comum
- [Porfiria hepática](https://raras.org/doenca/porfiria-hepatica) — ORPHA:659694 — 18 sintomas em comum
- [Síndrome do choque tóxico bacteriano](https://raras.org/doenca/sindrome-do-choque-toxico-bacteriano) — ORPHA:36234 — 17 sintomas em comum
- [Tumor endócrino enteropancreático](https://raras.org/doenca/tumor-endocrino-enteropancreatico) — ORPHA:100092 — 17 sintomas em comum
- [Doença do Legionário](https://raras.org/doenca/doenca-do-legionario) — ORPHA:549 — 16 sintomas em comum
- [Febre mediterrânica familiar](https://raras.org/doenca/febre-mediterranica-familiar) — ORPHA:342 — 16 sintomas em comum
- [Complicação após transplante de órgão](https://raras.org/doenca/complicacao-apos-transplante-de-orgao) — ORPHA:306644 — 16 sintomas em comum
- [Febre Q](https://raras.org/doenca/781) — ORPHA:781 — 16 sintomas em comum
- [Doença auto-inflamatória NLRP3-associada](https://raras.org/doenca/doenca-auto-inflamatoria-nlrp3-associada) — ORPHA:208650 — 16 sintomas em comum

## Importante

O Raras **não diagnostica e não prescreve**. Esta página é educativa e informativa.
Pacientes devem consultar profissionais de saúde qualificados para decisões clínicas.

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**Citação sugerida**: Raras.org — Peste. Disponível em: https://raras.org/doenca/peste
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**Formato RDF/Turtle**: https://raras.org/api/rdf?orpha=707