Carcinoma nasofaríngeo

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

NCT06064097

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

NCT05904080

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

NCT06980038

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

NCT03010150

Tislelizumab and Metronomic Capecitabine as Maintenance in High-risk Locoregionally-advanced Nasopharyngeal Carcinoma

NCT06093061

NCT06064097 · A Study Using Nivolumab, in Combination With Chemotherapy Dr…Recrutando

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NCT05904080 · Testing Nivolumab and Ipilimumab Immunotherapy With or Witho…Recrutando

NCT06980038 · Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Pr…Recrutando

NCT03010150 · Blood Tests and Questionnaires in Studying Adherence to Prev…Recrutando

NCT06093061 · Tislelizumab and Metronomic Capecitabine as Maintenance in H…Recrutando

NCT06029270 · Testing the Addition of BMS-986016 (Relatlimab) to the Usual…Recrutando

NCT06532279 · Testing the Addition of the Drug BMX-001, a Radioprotector, …Recrutando

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EARLY_PHASE1

NCT05941741 · IC Plus Low-dose Radiation Plus Cadonilimab in LANPCRecrutando

NCT07459296 · Becotatug Vedotin Plus Sintilimab in Locoregionally Advanced…Recrutando

NCT07412314 · Proton Therapy for Recurrent Nasopharyngeal CarcinomaRecrutando

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NCT06239727 · Reduced-dose Radiotherapy for Stage III Nasopharyngeal Carci…Recrutando

NCT06868433 · TMV Vaccine Therapy Alone and With Pembrolizumab for the Tre…Recrutando

PHASE1

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NCT06059261 · Envafolimab Combined With Chemoradiotherapy and Recombinant …Recrutando

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Outros ensaios clínicos

1.063 ensaios clínicos encontrados, 31 ativos.

Distribuição por fase

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PHASE1

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

📖Melhor nível de evidência: Revisão

Timeline de publicações

10.542 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 10.542

#1

PRELID2 promotes the progression of nasopharyngeal carcinoma by positively regulating the TXNDC12-GSH-GPX4 axis and inhibiting ferroptosis.

Cellular signalling2026 Mar 18

Nasopharyngeal carcinoma (NPC) treatment is challenged by advanced metastasis, high recurrence rates, and resistance to both radiotherapy and chemotherapy. PRELI domain-containing protein 2 (PRELID2) is overexpressed in cancers and linked to poor prognosis, but its role in NPC remains unclear. We utilized public datasets to analyze the expression characteristics and clinical prognostic significance of PRELID2 in NPC. The expression of PRELID2 in NPC cell lines was validated through Western blotting and quantitative reverse transcription PCR (qRT-PCR). The effects of PRELID2 on NPC cell proliferation, migration, and invasion were assessed using in vitro functional assays, such as CCK-8, colony formation, Transwell, wound healing assays, and an in vivo subcutaneous xenograft tumor model in nude mice. Downstream mechanisms were investigated through RNA-seq and rescue experiments. Both mRNA and protein levels of PRELID2 were elevated in NPC cells, and associated with poorer survival. In vitro experiments demonstrated that overexpression of PRELID2 significantly enhanced NPC cell proliferation, migration, and invasion. In vivo experiments confirmed that silencing PRELID2 markedly suppressed the growth of subcutaneous xenograft tumors in nude mice. RNA-seq and functional rescue validation revealed that PRELID2 positively regulates the expression of thioredoxin domain-containing protein 12 (TXNDC12), increasing intracellular GSH levels. The accumulation of GSH enhances GPX4 activity, effectively inhibiting ferroptosis in NPC cells and ultimately promoting tumor progression. PRELID2 promotes NPC by upregulating TXNDC12 to sustain GSH levels, thereby enhancing GPX4 activity, inhibiting ferroptosis, and driving tumor growth. Suggest PRELID2 as a potential prognostic biomarker and therapeutic target for NPC.

#2

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma.

Cancer science2026 Mar 20

The Epstein-Barr virus (EBV) has two life cycles: latent and lytic. Previously, the latent cycle had been considered more relevant to EBV-associated epithelial malignancies, including nasopharyngeal carcinoma (NPC), whereas the lytic cycle, which ultimately leads to the death of host cells, had not been considered. However, recent studies have revealed that abortive lytic infections, in which the lytic cycle halts midway, avoids host cell death and contributes to tumorigenesis and tumor growth. However, the progression of the lytic cycle in NPC and its association with viral replication remain unclear. This study aimed to perform morphological analyses of EBV-positive NPC cell lines and clinical NPC biopsy samples using transmission electron microscopy, NanoSuit-correlative light and electron microscopy, and scanning ion conductance microscopy. Virion-like particles were observed in lytically induced EBV-positive NPC cell lines using time-lapse imaging to capture their release. These particles were also detected in clinical NPC samples using electron microscopy. Immunohistochemical analysis with the glycoprotein B (gB) antibody revealed a strong association between gB expression and poor prognosis. In conclusion, lytic infections with EBV replication occur in NPC, and the frequency of EBV replication is significantly associated with poor prognosis.

#3

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.

JAMA oncology2026 Mar 19

It remains uncertain which Epstein-Barr virus (EBV)-related biomarkers provide the most reliable diagnostic performance for suspected nasopharyngeal carcinoma (NPC) in outpatient settings, especially regarding the novel anti-EBV BNLF2b total antibody (P85-Ab) assay. Clarifying their accuracy is critical to improving early detection and reducing misdiagnosis. To evaluate the diagnostic performance of the P85-Ab assay in suspected NPC in outpatient settings and compare it head-to-head with EBV viral capsid antigen (VCA)-immunoglobulin A (IgA), EBV early antigen (EA)-IgA, and EBV nuclear antigen 1 (EBNA1)-IgA. A prospective, multicenter cohort study was conducted between April 2021 and March 2024, with a median follow-up of 27.2 months in outpatient clinics across 5 medical centers in China. Key inclusion criteria comprised clinically suspected NPC. Data were analyzed from June 2025 to July 2025. P85-Ab was tested using chemiluminescent immunoassay. VCA-IgA, EA-IgA, and EBNA1-IgA were tested via enzyme-linked immunosorbent assays. Primary outcomes included sensitivity and specificity of P85-Ab. A total of 3795 eligible participants were consecutively recruited. After excluding individuals with low-quality samples or lost to follow-up, 3777 participants were included in the final analysis (1680 with NPC and 2097 without NPC). Among the 3777 evaluated participants (median [IQR] age, 49.0 [37.0-58.0] years; 65 % male), P85-Ab demonstrated superior diagnostic performance, with a sensitivity of 93.0% (95% CI, 91.6-94.0) and specificity of 97.3% (95% CI, 96.5-97.9). Other biomarkers showed lower sensitivity (ranging from 60.4% to 93.0%) and specificity (<90%). P85-Ab maintained high sensitivity among asymptomatic individuals (92.0%; 95% CI, 85.9-95.6) and those presenting with NPC-nonspecific symptoms (88.4%; 95% CI, 75.5-94.9), with no additional diagnostic benefit observed from the triplet-antibody strategy combining P85-Ab, VCA-IgA, and EBNA1-IgA. However, among participants with NPC-specific symptoms, the triplet-antibody strategy improved sensitivity compared with P85-Ab alone (95.9%; 95% CI, 94.8-96.8 vs 93.1%; 95% CI, 91.7-94.3; P < .001). In this cohort study, P85-Ab was a robust and accurate biomarker for suspected NPC in outpatient settings. P85-Ab alone may be suggested for populations with asymptomatic or NPC-nonspecific symptoms, and combining P85-Ab with VCA-IgA and EBNA1-IgA may be suggested for populations with NPC-specific symptoms.

#4

Epstein-Barr virus drives nasopharyngeal carcinoma metastasis via RNA m5C modification of ICAM-1 mediated by NSUN2 and YBX3.

Cell death and differentiation2026 Mar 18

Epstein-Barr virus (EBV) is a critical epigenetic regulator in nasopharyngeal carcinoma (NPC) pathogenesis, primarily through well-established mechanisms involving DNA methylation and histone modifications. However, the contribution of RNA modifications, especially RNA 5-methylcytosine (m5C), to EBV-driven NPC progression remains largely unclear. Here, we performed RNA bisulfite sequencing (RNA-Bis-seq) on NPC cells and observed a global elevation in RNA m5C levels following EBV infection. Notably, EBV infection upregulated NSUN2, a known RNA m5C methyltransferase ("writer"), through LMP1-mediated activation of the NF-κB signaling pathway, leading to RNA m5C elevation. Functional assays confirmed that NSUN2 significantly enhances NPC cell migration and metastasis through its RNA m⁵C catalytic activity. Furthermore, we identified YBX3 as a novel RNA m⁵C-binding protein ("reader") that was simultaneously upregulated upon EBV infection. Mechanistically, NSUN2 catalyzed m5C modification on ICAM-1. Subsequently, YBX3 specifically recognized the modified site, recruiting PABPC1 through interacting with its cold shock domain and thereby enhancing ICAM-1 translation. Consistently, ICAM-1 overexpression effectively rescued the metastasis defects induced by NSUN2 knockdown. Additionally, we observed significant positive correlations among NSUN2, YBX3, and ICAM-1 expression levels in NPC tissues, with their expression strongly associated with tumor progression and poor prognosis. Together, our findings reveal the crucial role of RNA m5C modification in EBV-associated NPC progression, delineate the LMP1/NSUN2/YBX3/ICAM-1 signaling cascade, and suggest this regulatory axis as a potential therapeutic target for NPC.

#5

A potent human neutralizing antibody targeting the receptor-binding site in the glycoprotein gp350 of Epstein-Barr virus.

Science China. Life sciences2026 Mar 13

The Epstein-Barr virus (EBV) is associated with multiple lymphoid malignancies and autoimmune diseases. The glycoprotein gp350, the most abundant envelope protein on the EBV virion surface, has been the primary target for the vaccine design. However, all the attempts have failed to prevent asymptomatic infection in clinical trials. This setback highlights an incomplete understanding of the immune response to gp350 and emphasizes the need for more comprehensive antibody studies. Here, we identified three human-derived anti-gp350 monoclonal antibodies from a nonimmune human scFv library. Of these, the S54 antibody exhibited a potent neutralizing activity against virus infection of Raji B cells. Using cryo-EM, we resolved the structure of the S54-gp350 complex, revealing that the S54 epitope substantially overlaps with the CR2 recognition site. Our findings elucidate the molecular mechanism by which anti-gp350 antibodies block EBV infection of B cells in vitro, providing valuable insights for antibody-based therapy and vaccine development.

Publicações recentes

[Corrigendum] MicroRNA‑122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro.

🥉 Relato de caso

Mol Med Rep2026 Jun

Alterations in NK cell subsets and the regulatory role of JAB1 in nasopharyngeal carcinoma with implications for tumor immunity and biomarker development.

Br J Cancer2026 Apr 16

Childhood Nasopharyngeal Carcinoma: A Rare Disease with Distinct Features and Favorable Prognosis.

📖 Revisão

Int J Radiat Oncol Biol Phys2026 Apr 14

Dumbbell-Structured Plasmonic-Enhanced Optical Nanoprobes Boosting Photo-Magnetic-Acoustic Multimodal Imaging-Guided Photodynamic-Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma.

🥉 Relato de caso

Adv Sci (Weinh)2026 Apr 16

Association of Basal Thyroid Function with Clinical Outcomes in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma Treated with PD-L1 Inhibitor KL-A167: A Multicenter Post-hoc Analysis.

💬 Opinião

Endocr Connect2026 Apr 16

Ver todas no PubMed

📚 EuropePMC15.067 artigos no totalmostrando 196

Evaluation of the pterygoid process pneumatization and sclerosis with Vidian canal morphology using computed tomography: a comparative study in nasopharyngeal carcinoma patients and healthy controls.

Folia morphologica

A phase II randomized controlled trial of orally administered yeast-derived β-glucan for alleviating chemoradiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients.

A modified homogeneity index for multi- target radiotherapy plans by subtracting high-dose subvolumes.

PeerJ

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Analysis on hospitalization expenditures and influencing factors in nasopharyngeal cancer patients].

Diagnostic performance analysis of two-gene methylation in urothelial carcinoma based on small-volume urine sample.

Cancer

Journal of human genetics

Interaction between human oxoguanine glycosylase 1 gene polymorphisms and smoking status on nasopharyngeal carcinoma risk.

International journal of immunopathology and pharmacology

Nasopharyngeal mass containing B-cell small lymphocytic lymphoma in a human immunodeficiency virus-positive patient: A case report and review of the literature.

Prognostic value of early Epstein-Barr Virus DNA response in patients with locoregionally advanced nasopharyngeal carcinoma.

Otolaryngologia polska = The Polish otolaryngology

Comparison of the eighth and ninth editions of American Joint Committee on Cancer/Union for International Cancer Control staging for non-metastatic nasopharyngeal carcinoma.

Interpretable AI for treatment decision-making in immunoradiotherapy of locally advanced nasopharyngeal carcinoma.

Clinical Outcomes and Individualized Seed Implantation Planning for Iodine-125 Seeds Brachytherapy in Lymph Node Metastases.

Journal of Cancer

American journal of cancer research

Integrin α5β1 in head and neck squamous cell carcinoma: expression, mechanisms, and clinical implications.

American journal of cancer research

SSTR2-targeting therapy in EBV-positive and EBV-negative metastatic nasopharyngeal carcinoma.

PRELID2 promotes the progression of nasopharyngeal carcinoma by positively regulating the TXNDC12-GSH-GPX4 axis and inhibiting ferroptosis.

Cellular signalling

PD-1/PD-L1 inhibitors in recurrent or metastatic nasopharyngeal carcinoma: A systematic review and meta-analysis.

Medicine

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma.

Cancer science

Cancer management and research

Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Nasopharyngeal Carcinoma in Non-Endemic Regions: A Single-Arm Phase 2 Clinical Trial.

The dual regulatory role of METTL14-mediated m6A modification in tumorigenesis and its underlying mechanisms.

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma.

JAMA oncology

Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma.

Frontiers in immunology

Cell death and differentiation

Epstein-Barr virus drives nasopharyngeal carcinoma metastasis via RNA m5C modification of ICAM-1 mediated by NSUN2 and YBX3.

Identifying key risk factors for thrombocytopenia in patients undergoing radical chemoradiotherapy for nasopharyngeal cancer: a retrospective study.

PFAS and adipokines: Decoding their roles in the risk of breast nodules and breast cancer.

Environmental research

Prevention and management of radiation dermatitis for patients with nasopharyngeal carcinoma: a best practice implementation project.

BMC nursing

Nasopharyngeal carcinoma radiation-induced sarcoma in the skull base: a retrospective follow-up cohort study.

BMC surgery

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Gender disparities in the global burden of nasopharyngeal carcinoma: persistence and evolution of male predominance.

The value of time-dependent diffusion MRI in nasopharyngeal carcinoma: correlation with prognostic factors.

European radiology

Science China. Life sciences

A potent human neutralizing antibody targeting the receptor-binding site in the glycoprotein gp350 of Epstein-Barr virus.

Nuclear medicine communications

Breaking the shackles of morphology: a novel perspective on immunotherapy evaluation for nasopharyngeal carcinoma using multimodal imaging and radiomics - a review.

The American journal of surgical pathology

Micronests in Tumor Stroma is a Prognostic Classifier in Nasopharyngeal Carcinoma.

Radiation oncology (London, England)

Patterns of regional recurrences after treatment of nasopharyngeal carcinoma.

A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs.

FineST: contrastive learning integrates histology and spatial transcriptomics for nuclei-resolved ligand-receptor analysis.

Anti-Hu paraneoplastic syndrome with gastrointestinal dysmotility associated with nasopharyngeal squamous cell carcinoma and small bowel adenocarcinoma.

BMJ case reports

Journal of visualized experiments : JoVE

Position-Guided Nasopharyngeal Irrigation for Post-Radiotherapy Ulcer Care in Nasopharyngeal Carcinoma.

Industry update January 2026.

Therapeutic delivery

International journal of surgery case reports

Brain abscess following acute otitis media in a nasopharyngeal carcinoma survivor: a case report.

Cancer management and research

Efficacy and Safety of Nanoparticle Albumin-Bound Paclitaxel Compared to Docetaxel Plus Nedaplatin as Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma: A Propensity Score Matching Analysis.

Annali italiani di chirurgia

Deep Learning-Based Videomics for Automatic Segmentation in Endoscopic Endonasal Surgery.

LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma.

Oncogene

International journal of radiation oncology, biology, physics

Combined Real-time Liquid Biopsy with TNM Stage to Guide Induction Chemotherapy Cycles in Nasopharyngeal Carcinoma: A Development and Validation Study.

International dental journal

Nasopharynx on Cone-beam Computed Tomography.

Lack of De-Intensification Models for Female Head and Neck Cancer Patients With Favorable Prognosis.

Cancer medicine

Journal of clinical medicine

Diagnostic and Economic Evaluation of [18F]FDG PET/CT Versus MRI for Lymph Node Staging in Nasopharyngeal Carcinoma: Implications for Individualized Upper-Neck-Only Irradiation.

High VRK2 expression level predicts unfavorable survival outcomes in nasopharyngeal carcinoma.

Precision management of radiotherapy interruption in locoregionally advanced nasopharyngeal carcinoma: Induction chemotherapy counteracts the survival impact in high-risk patients defined by a novel model.

Translational oncology

Limitations of quality-of-life assessment and long-term side effects in nasopharyngeal carcinoma: a narrative review.

Applied biochemistry and biotechnology

PKM2 Deficiency Results in Reduced Proliferation of Nasopharyngeal Carcinoma Cells by Deactivation of Nrf2-HO-1-GSH Signaling.

Radiology. Imaging cancer

68Ga-FAPI PET/CT in Nasopharyngeal Carcinoma: A Paradigm Shift in Imaging or Just Another Tool?

International journal of molecular medicine

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway.

Brain imaging and behavior

The correlation between olfactory bulb volume and T&T odor threshold: a systematic review and meta-analysis.

Quantitative imaging in medicine and surgery

Developing a segmentation cascade deep learning network based on automated prompts.

International journal of surgery case reports

A pediatric nasopharyngeal carcinoma masquerading as Kimura disease: a rare case report from Nepal.

Bioinformatics identification of adenosylhomocysteinase (AHCY) as a regulator of ferroptosis in nasopharyngeal carcinoma cells via the Hippo-Yes-associated protein (Hippo-YAP) pathway.

Multi-parameter magnetic resonance imaging (MRI) deep learning radiomics predicts complete response after induction immunochemotherapy in locally advanced nasopharyngeal carcinoma.

The roles and pathways of Hsa_circ_0000285 in cancer: a potential target for cancer therapy.

Cell division

Infectious agents and cancer

Assessing T-cell responses to Epstein-Barr virus in individuals at risk for nasopharyngeal carcinoma.

Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma.

Nature

m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.

Molecular immunology

International journal of radiation biology

Changes of F-18 fluorodeoxyglucose positron emission tomography/computed tomography textural features in temporal lobe after radiotherapy for nasopharyngeal carcinoma.

Cross-technique transfer learning to predict the dose distribution for radiotherapy planning based on a limited sample size.

Medical physics

Harnessing the immune microenvironment: advances in nasopharyngeal carcinoma immunotherapy.

Cell death discovery

A Telemedicine App for Nonrigid Facial Rehabilitation Training Enhanced by Efficient Fully Convolutional Neural Network With Residual Network (EffiFCNN-ResNet) to Improve Accessibility for Patients With Nasopharyngeal Carcinoma Cancer: Randomized Controlled Trial.

JMIR mHealth and uHealth

Prediction of treatment outcome in nasopharyngeal carcinoma patients.

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy.

Nature cell biology

Journal of medical biochemistry

Impact of PDCA cycle-driven nutritional support on serum biomarkers and quality of life in nasopharyngeal carcinoma patients undergoing radiotherapy.

Chinese clinical oncology

Cadonilimab plus chemotherapy in recurrent or metastatic nasopharyngeal carcinoma: a step forward for bispecific immunotherapy?

The evaluation value of multiparametric imaging technology (MULTIPLEX) for grading and molecular subtyping of diffuse glioma patients.

Clinical radiology

Genomics, proteomics & bioinformatics

The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell.

Integrated bioinformatics analysis and experimental validation reveal Pevonedistat as a promising therapeutic agent modulating the CRL4-DTL-p21/p53 axis in nasopharyngeal carcinoma.

Hereditas

A nutritional risk index-based nomogram for predicting prognosis and identifying induction chemotherapy beneficiaries in nasopharyngeal carcinoma.

Scientific reports

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

Current opinion in oncology

Recent highlights and breakthroughs in immunotherapy for head and neck cancers.

Current opinion in oncology

Circulating Epstein-Barr virus DNA as a precision biomarker in nasopharyngeal carcinoma: from risk stratification to real-time treatment adaptation and disease surveillance.

Advances in immunotherapy and targeted therapy for nasopharyngeal carcinoma: Current progress and combined approaches (Review).

Oncology reports

Brain Metastasis in Nasopharyngeal Carcinoma: A Case Report.

Case reports in oncology

Next-generation sequencing for DLBCL patients with early failure after frontline R-CHOP chemo-immunotherapy.

Efficacy, safety, and survival outcomes of radiotherapy combined with nimotuzumab following induction chemotherapy in locally advanced head and neck cancer.

Multimodal intervention for sarcopenia in nasopharyngeal carcinoma patients undergoing definitive treatment: a pilot randomized controlled trial protocol.

Nutrition journal

Becotatug Vedotin: First Approval.

Drugs

Pre-treatment peripheral absolute monocyte count predicts metastatic progression and survival outcomes in treatment-naive non-metastatic nasopharyngeal carcinoma.

Synergistic carcinogenesis of the nasopharyngeal microbiome and Epstein-Barr virus: mechanisms of metabolic reprogramming and immune evasion.

Frontiers in immunology

HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease.

Nature immunology

Chemico-biological interactions

Tetrahydroberberine targets the bcl-2 promoter G-quadruplex to trigger mitochondrial apoptosis and inhibit nasopharyngeal carcinoma progression.

Comparative efficacy of tympanostomy tube insertion for secretory otitis media following radiotherapy for head and neck malignancies: a network meta-analysis.

Acta oto-laryngologica

SMURF1 Regulates CTCF-HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma.

Cancer science

Journal of nanobiotechnology

Plasmonic platinum-tipped gold nanorods for tumor-targeted multimodal imaging diagnosis and NIR-II photothermal-catalytic-immuno synergetic therapy.

Prediction of Neoadjuvant Chemotherapy Efficacy for Locally Advanced Nasopharyngeal Carcinoma Using MRI-Based Deep Learning Features Combined with Vision Transformer.

Academic radiology

Cluster-Based MR Radiomics Model for Predicting Induction Chemotherapy Response in Nasopharyngeal Carcinoma.

Academic radiology

IEEE journal of biomedical and health informatics

RT-SAM: Visual-Prompt Fusion and Uncertainty Enhancement for Nasopharyngeal Carcinoma Radiotherapy Target Delineation.

Radiation oncology (London, England)

Comparative effectiveness of Volumetric Modulated Arc Therapy versus tomotherapy in locally advanced nasopharyngeal carcinoma: a propensity score-matched retrospective cohort study.

Journal of molecular histology

Autophagy hub genes mediate photodynamic therapy tolerance in nasopharyngeal carcinoma through cytoprotective autophagy and survival signaling.

Swallowing-related outcomes and organ-at-risk dosimetry after proton versus photon radiotherapy in nasopharyngeal carcinoma.

Regarding "Endoscopic surgery versus conservative treatment in nasopharyngeal carcinoma patients with nasopharyngeal necrosis": the potential confounding role of nutritional support.

Rhinology

Candesartan cilexetil as a repurposed therapeutic candidate for nasopharyngeal carcinoma: Integrated in vitro and in silico analyses.

EXCLI journal

Cancer pathogenesis and therapy

The global landscape of particle beam radiotherapy trials over the past 15 years.

Frontiers in endocrinology

Nonlinear association of serum uric acid and C-peptide with arterial stiffness in patients with type 2 diabetes: a real-world study.

Cellular & molecular biology letters

Pseudouridine synthases upregulate 5'-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma.

Molecular therapy : the journal of the American Society of Gene Therapy

LncRNA Gm16023 limits M1 macrophage-mediated hyperglycemia-exacerbated septic intestinal injury via miR-377-3p/Sirt1 axis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Predicting Macrophage Spatial Localization from Single-Cell Transcriptomes to Uncover Disease Mechanisms.

Medicina (Kaunas, Lithuania)

Role of Prognostic Nutritional Index and C-Reactive Protein/Albumin Ratio in Prognosis of Locally Advanced Nasopharyngeal Carcinoma.

Extracellular Vesicles: A Multidimensional Role in the Occurrence and Development of Nasopharyngeal Carcinoma.

Biomolecules

Nasopharyngeal Carcinoma at the Virology Precision Oncology Nexus: Decoding Molecular Alterations for Early Intervention and Therapeutic Innovation.

Biomolecules

Humanistic nursing care and quality of life in patients with nasopharyngeal carcinoma: a prospective observational study.

BMC nursing

Pedicled Inferior Turbinate-Nasal Floor and Septal Mucoperiosteal Flap Resurfacing for PRNN.

The Laryngoscope

Efficacy of radiotherapy to metastatic lesion in de novo metastatic nasopharyngeal carcinoma patients: A multicenter, propensity score matching study.

First-Line Tislelizumab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Cancer: Three-Year Follow-Up of the Phase 3 RATIONALE-309 Randomized Clinical Trial.

JAMA oncology

European radiology experimental

Predicting induction chemotherapy response based on tumor-stroma ratio and pretreatment synthetic MRI in nasopharyngeal carcinoma.

Predictive Modeling of Treatment-Related Thyroid Dysfunction and Prognostic Implication in Advanced Nasopharyngeal Carcinoma With PD-1 Inhibitors.

The oncologist

Cancer immunology, immunotherapy : CII

PD-1 inhibitors combined with induction chemotherapy followed by chemoradiotherapy in HPV-negative locally advanced head and neck squamous cell carcinoma: a real-world study.

The ubiquitin-proteasome system is an important driver of EBV-associated nasopharyngeal carcinoma progression: a meta-analysis of transcriptomic data.

Scientific reports

Ecotoxicology and environmental safety

Integrative computational and experimental analysis identifies MEK-mediated carcinogenic effects of bisphenol A and diethyl phthalate in head and neck cancer.

Reviews in medical virology

A Deep Dive Into Oncogenic Viruses Understanding Their Role in Cancer and Approaches for Prevention.

Molecular therapy : the journal of the American Society of Gene Therapy

Lactate-induced miR-7-5p/TRIM33 reprograms metabolic flux to suppress tumor growth and viral reactivation.

A survey to evaluate the knowledge of Syrian dental students about oral manifestation of systemic diseases: A cross-sectional study.

Medicine

Lancet regional health. Americas

Nonmetastatic nasopharyngeal carcinoma: in search of safer therapies.

International journal of cancer

Comparison of ≥2 lines immunotherapy regimens for recurrent/metastatic nasopharyngeal carcinoma.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

A Multimodal fusion model for predicting nasopharyngeal necrosis after re-irradiation in recurrent nasopharyngeal carcinoma.

Becotatug vedotin, MRG003, in previously treated recurrent or metastatic nasopharyngeal carcinoma: A multicenter, single-arm, phase IIa trial.

Med (New York, N.Y.)

Elucidating EGCG' s targets in nasopharyngeal carcinoma through combined cell-based assays and transcriptomic sequencing.

Discover oncology

Radiology. Imaging cancer

Prospective Head-to-Head Comparison of 18F-FDG and 68Ga-FAPI PET/CT in De Novo and Recurrent Epstein-Barr Virus-associated Nasopharyngeal Carcinoma.

A Rare Metastatic Squamous Cell Carcinoma of the Lacrimal Sac Originating from Nasopharyngeal Carcinoma: A Case Report.

Reports (MDPI)

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Neoadjuvant Chemotherapy With CAPOX Versus Chemoradiation for Locally Advanced Rectal Cancer With Uninvolved Mesorectal Fascia (CONVERT): Final Results of a Phase III Trial.

Epidemiological study on nasopharyngeal cancer in Morocco: Case of the University Hospital Center Mohammed VI in Marrakech.

La Tunisie medicale

Pediatric Nasopharyngeal Carcinoma (NPC).

Current oncology reports

METTL14 modulates the nasopharyngeal carcinoma microenvironment via m6A-modified YWHAH identified through single-cell and machine learning analyses.

Frontiers in immunology

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Corrigendum to "Evaluation and analysis of risk factors of hearing impairment for nasopharyngeal carcinoma treated using intensity-modulated radiotherapy". [Radiother Oncol. 190 (2024) 109985].

Low-dose fractionated radiotherapy combined with induction chemotherapy in high-risk nasopharyngeal carcinoma: An open-label, randomized phase 2 trial.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

SEOM-TTCC clinical guideline for nasopharyngeal carcinoma (update 2025).

Journal of cancer survivorship : research and practice

Network analysis of symptom clusters and core symptom changes in nasopharyngeal cancer survivors: a longitudinal study.

Potential of non-specific blood biomarkers combined with EBV-specific antibodies for triaging in nasopharyngeal carcinoma screening.

Scientific reports

Safety and Efficacy of Salvage Treatment for Recurrent Nasopharyngeal Carcinoma: A Single-Center Retrospective Study Over 10 Years.

Cancer medicine

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Palmitoylation modification of SPI1 promotes nasopharyngeal carcinoma radioresistance through inhibiting c-CBL-mediated ubiquitination and degradation.

Radiation oncology (London, England)

The regional-control of prophylactic irradiation dose reduction of level Va in nasopharyngeal carcinoma (NPC).

Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma.

Med (New York, N.Y.)

Cancer cell international

Research on EBV-miR-BART17-5p targeted Inhibition of ARID1A expression to regulate nasopharyngeal carcinoma dedifferentiation.

Multi-institutional deep learning for GTV segmentation and survival prediction in nasopharyngeal carcinoma.

BMC medical imaging

Malnutrition-related symptom clusters and quality of life in nasopharyngeal carcinoma patients during radiotherapy: a network analysis.

An 18F-FDG PET/CT-based radiomics nomogram for predicting progression-free survival in nasopharyngeal carcinoma: A retrospective cohort study.

Medicine

Interactions between hematological biomarkers of virus infection and immune cells in mediating distant metastasis in nasopharyngeal carcinoma: insights into prognosis and induction chemotherapy administration.

Radiology and oncology

Generalization of the Conformity Index for Multi-Target Radiotherapy Plans.

Cancers

Comprehensive Characterization of Stem Cell Landscape Identifies Novel Stemness-Relevant Genes for Nasopharyngeal Carcinoma Therapy.

Cancers

American journal of translational research

Prognostic factors and treatment outcomes in nasopharyngeal carcinoma patients with liver metastasis.

Long-term outcomes and patient profiles following intensity-modulated radio-chemotherapy for nasopharyngeal cancer in a nonendemic region.

Inhibition of radiotherapy sensitivity in nasopharyngeal carcinoma via the long non-coding RNA RHPN1-AS1.

Optimizing the therapeutic ratio: a narrative review of de-escalation and response-adapted strategies in series including human papillomavirus negative head and neck cancer.

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

[Comprehensive rehabilitation management of swallowing dysfunction after radiotherapy and chemotherapy for nasopharyngeal carcinoma].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

[Integrated multitask visual-guided system for nasopharyngeal carcinoma detection using nasopharyngeal endoscopy: a retrospective multicenter study].

Journal of translational medicine

A machine learning-based predictive model for radiosensitivity in nasopharyngeal carcinoma utilizing serum proteomics.

A Case Report of a Multisystemic Immune-Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha-1.

Clinical case reports

Undifferentiated Nasopharyngeal Carcinoma in Low- and Middle-Income Countries: Clinical, Molecular, and Health-System-Related Challenges.

Cureus

Therapeutic advances in medical oncology

Immunotherapy for locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of randomized clinical trials.

Dual-activated fluorescent probe for the study of the mechanism of SO2 and NO in cisplatin resistance of nasopharyngeal carcinoma.

RSC advances

ZNF844 Suppresses Invasion and Metastasis in Nasopharyngeal Carcinoma by Inhibiting the PI3K-AKT Signaling Pathway.

Cancer science

Final survival analysis of induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by concurrent chemoradiotherapy in nasopharyngeal carcinoma: a multicenter, randomized, phase 3 trial.

SDC1+ CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers.

Gut

BMJ (Clinical research ed.)

Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial.

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8+T cell-mediated anti-tumor immunity.

Phenomics (Cham, Switzerland)

Integrin α6 Targeted Tumor Theranostics.

International journal of clinical and experimental pathology

Lactoferrin inhibits anoikis-resistance and metastasis of nasopharyngeal carcinoma cells via the AKT signaling pathway.

European journal of nuclear medicine and molecular imaging

Multimodal glyco-lipid-EBVDNA signature prognostic model for individualized risk stratification of locally advanced nasopharyngeal carcinoma.

Development and validation of prognostic nomograms based on peripheral blood T-cell counts and their dynamic changes for patients with nasopharyngeal carcinoma receiving radiotherapy.

Translational oncology

Ear, nose, & throat journal

Addressing Etiological Factors of Nasopharyngeal Carcinoma in Kenyan Mountains.

Journal of translational medicine

Neutrophils in nasopharyngeal carcinoma: from mechanisms to therapeutics.

Incidence and spectrum of immune-related adverse events in nasopharyngeal carcinoma patients treated with immune checkpoint inhibitors.

Med (New York, N.Y.)

Improving prediction accuracy of radiation-induced temporal lobe injury in nasopharyngeal carcinoma using ADC-based deep learning and dosiomics.

Prognostic nomogram for patients with HER2-negative metastatic gastric cancer receiving first-line PD-1 blockade.

ESMO open

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Genetic associations of LXN polymorphisms with toxicities of platinum-based concurrent chemoradiotherapy of nasopharyngeal carcinoma.

Journal of medical virology

Epstein-Barr Virus Infection at Single-Cell Resolution.

FOLR1 Mediated by ITCH Promotes Paclitaxel Resistance by Suppressing Pyroptosis in Nasopharyngeal Carcinoma.

Archiv der Pharmazie

Molecular therapy : the journal of the American Society of Gene Therapy

BCAT1-elicited branched-chain amino acid catabolism fosters neutrophil-mediated pan-metastasis in pancreatic cancer.

Fusobacterium nucleatum manipulates host autophagy to promote its intracellular survival and treatment resistance in nasopharyngeal carcinoma.

Molecular cancer

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Yiqi Jiedu Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway].

Androgen receptor may promote tumor progression via TTF-1/EGFR pathway in metastatic nasopharyngeal carcinoma.

Translational oncology

International immunopharmacology

USP18 orchestrates malignant progression in nasopharyngeal carcinoma through UBR5-driven attenuation of p53 signaling.

Clinical nuclear medicine

Refining M1-Stage Stratification in De Novo Metastatic Nasopharyngeal Carcinoma Using 18F-FDG PET/CT: Preliminary Evidence.

Current topics in microbiology and immunology

The Biology and Clinical Utility of EBV Monitoring in Blood.

Analysis of Plasma Epstein-Barr Virus DNA and Clinical Outcomes to Pembrolizumab or Chemotherapy in Recurrent/Metastatic Nasopharyngeal Cancer in KEYNOTE-122.

Cancer medicine

International journal of cancer

The value of nasopharyngeal brush versus plasma EBV DNA detection in diagnosing local recurrence of nasopharyngeal carcinoma.

Artificial intelligence-assisted real-time nasopharyngeal cancer diagnostic model enhances rhinologist performance: a prospective multi-reader study.

Annals of medicine

A broadly protective antibody targeting gammaherpesvirus gB.

Nature

Journal of visualized experiments : JoVE

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein.

Dose-guided individualized planning target volume margin optimization in nasopharyngeal carcinoma: a retrospective megavoltage computed tomography-based cumulative analysis.

Cancer communications (London, England)

Endopharyngeal Ultrasound-Guided Transpharyngeal Needle Aspiration for Confirming Retropharyngeal Lymph Nodes' Metastasis among Nasopharyngeal Carcinoma Patients.

MADAT: Missing-aware dynamic adaptive transformer model for medical prognosis prediction with incomplete multimodal data.

Medical image analysis

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

MRI-based deep learning model predicts recurrent nasopharyngeal carcinoma in post-radiation nasopharyngeal necrosis.

Five-Year Outcome of Camrelizumab Plus Chemotherapy in Recurrent or Metastatic Nasopharyngeal Carcinoma: A Secondary Analysis of the CAPTAIN-1st Randomized Clinical Trial.

JAMA oncology

World journal of clinical oncology

Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens.

Molecular and clinical oncology

Prognostic value of serum uric acid levels following radiotherapy and chemotherapy in nasopharyngeal carcinoma.

Non-Gaussian diffusion MRI using CTRW and FROC models for early treatment response assessment in nasopharyngeal carcinoma.

BMC medical imaging

IEEE journal of biomedical and health informatics

M $^{3}$ SegNet: A Multi-Modal and Multi-Branch Framework for Nasopharyngeal Carcinoma Segmentation in Radiotherapy Planning.

Cellular oncology (Dordrecht, Netherlands)

Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma.

Clinical and translational medicine

deltaHED predicts survival and immune evasion in PD-1 blockade therapy: A multi-cohort study across three cancer types.

Medicina (Kaunas, Lithuania)

Comparison of Local Control and Toxicity in T4 Nasopharyngeal Carcinoma Patients Treated with Induction Chemotherapy and Intensity-Modulated Radiotherapy: Conventional vs. Hyperfractionated Regimens.

Overcoming chemoresistance in nasopharyngeal carcinoma: minocycline as a mitochondrial translation inhibitor.

Discover oncology