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Degeneração marginal pelúcida
ORPHA:137672CID-10 · H18.7CID-11 · 9A78.4DOENÇA RARA

Queratocone é uma doença do olho que resulta numa alteração progressiva do formato da córnea. Esta alteração pode causar visão desfocada, visão dupla, miopia, astigmatismo e fotossensibilidade. Geralmente afeta os dois olhos. Nos casos mais graves pode ser observada na córnea uma cicatriz ou um círculo pigmentado.

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Introdução

O que você precisa saber de cara

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Degeneração marginal pelúcida é uma doença rara que causa afinamento progressivo e irregular na córnea, geralmente na periferia inferior, levando a astigmatismo irregular e perda visual. Afeta ambos os olhos, mas pode ser assimétrica.

Pesquisas ativas
1 ensaio
10 total registrados no ClinicalTrials.gov
Publicações científicas
268 artigos
Último publicado: 2026 Apr
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SUS: Sem cobertura SUSScore: 0%
CID-10: H18.7
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Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico268PubMed
Últimos 10 anos132publicações
Pico202019 papers
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2026Hoje · 2026🧪 2007Primeiro ensaio clínico📈 2020Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Os sinais que médicos procuram e os exames que confirmam

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Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

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Publicações mais relevantes

Timeline de publicações
135 papers (10 anos)
#1

Common and Distinct Features in Serum Proteomic Profiles in Keratoconus, Post-Laser Vision Correction Ectasia, and Pellucid Marginal Degeneration.

Investigative ophthalmology & visual science2026 Mar 02

Both intrinsic and extrinsic factors are implicated in keratoconus (KTCN), pellucid marginal degeneration (PMD), and post-laser vision correction (PLVC) ectasia etiology. Serum proteomic profiling was performed to molecularly differentiate the ectasia and to assess systemic components in their pathophysiology. Serum samples from 93 patients with KTCN, 10 patients with PLVC, 4 patients with PMD, and 44 non-ectatic controls were profiled using matrix-assisted laser desorption ionization-time of flight tandem mass spectrometry (MALDI-TOF/TOF MS/MS). Clinical and environmental variables (e.g. allergy/atopy/asthma and eye rubbing intensity), together with ophthalmologic parameters (K1, K2, Kmax, TCT, and anterior/posterior elevation), were assessed in the principal component analysis (PCA), Weighted Gene Co-expression Network Analysis (WGCNA), linear modeling, and other assessments. Serum m/z features were correlated with RNA-seq data from corneal epithelium (CE) samples of 31 individuals. As findings of the PCA, associations were observed for atopy and/or asthma (estimate = -5.52, P = 0.03), PMD diagnosis (estimate = 8.3, P = 0.04), and age (estimate = -0.14, P = 0.01), with observable trends for KTCN status and intense eye rubbing. Correlations between clinical variables and individual m/z features indicated that posterior elevation, reflecting KTCN severity, was associated with an ATP5B protein-assigned peak (m/z 1921.9655, ρ = -0.31, adjusted P = 0.016). In the integration analyses, correlations between serum peaks and corresponding CE gene expression, including APOH- (ρ = 0.43, P = 0.017) and ALB-assigned peaks (ρ = 0.35-0.42, P < 0.05) were identified. Pairwise eigengene comparisons showed negative correlation between KTCN and non-ectatic controls (Pearson r = -0.89, P = 0.007). The local ocular pathology is reflected in serum proteomic profiles, together with accompanying systemic inflammation and intense eye-rubbing behavior. Common proteomic features of different types of corneal ectasia may reflect overlapping pathophysiological mechanisms.

#2

Acute Corneal Hydrops: A Comprehensive Review of Diagnosis, Treatment, and Outcomes.

Cornea2026 Feb 01

This review provides an overview of acute corneal hydrops (ACHs), focusing on their risk factors, epidemiology, pathogenesis, imaging techniques, and treatment options. This narrative review was based on a literature search conducted in PubMed and Google Scholar, covering publications from 1980 to 2025. No restrictions were applied regarding language or study type. The identified studies were assessed for their relevance and clinical applicability to the diagnosis, management, and outcomes of ACHs. ACHs are linked with corneal conditions like keratoconus (2.6%-7.5%), pellucid marginal degeneration (6%-11.5%), and keratoglobus (11%). It arises from structural changes in Bowman layer and the anterior stroma, triggered by factors such as trauma and increased intraocular pressure, leading to rupture of Descemet membrane. Risk factors include chronic allergic eye diseases (eg, vernal and atopic keratoconjunctivitis), eye rubbing, developmental conditions (eg, Down syndrome), early age, steeper keratometry, and reduced visual acuity at presentation. Imaging techniques such as ultrasound biomicroscopy, anterior segment optical coherence tomography, and in vivo confocal microscopy aid in characterizing CHs, monitoring recovery, and detecting complications. Treatments aim to reduce discomfort, promote healing, prevent complications, and support future visual rehabilitation. ACH develops in several corneal disorders, with risk factors overlapping those of keratoconus. Advances in imaging have improved the understanding of corneal changes, aiding in treatment and follow-up strategies. Despite various treatment options, no consensus exists on the best approach, underscoring the need for further studies to refine management and improve patient outcomes.

#3

Update on pellucid marginal degeneration.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026 Feb

To review recent developments (2014-2024) in the diagnosis and treatment of pellucid marginal degeneration (PMD), focusing on advances in corneal imaging technologies, biomechanical assessments, and the effectiveness of current contact lens treatments and surgical techniques. Additionally, to discuss the role of PMD in cataract surgery and the use of toric intraocular lenses (IOLs). Structured search of PubMed, Scopus, and Embase (Nov 2024; Jan 2014-present) using PMD-related keywords/MeSH. After dual independent screening of 129 citations using predefined inclusion/exclusion criteria, 50 articles met eligibility and were included. Recent technologies enable better assessment of corneal curvature and pachymetry relationships, aiding differentiation of PMD from other ectatic diseases. Advances in biomechanical assessments have improved early detection and diagnostic precision. Most patients can be managed conservatively with new types of rigid contact lenses. Modified corneal cross-linking (CXL) protocols show promise in stabilizing the disease. Lamellar transplants offer visual outcomes comparable to penetrating keratoplasty with fewer complications. Wedge resection shows promising outcomes, but larger studies with long-term follow-up are still required. In cataract surgery, toric IOLs may provide effective astigmatism correction in selected PMD patients.  The diagnosis and treatment of PMD have significantly evolved in the last decade. Improved imaging and biomechanical assessments aid in accurate diagnosis. Contact lenses and lamellar surgery are mainstay treatments. Future clinical studies should focus on the CXL protocols.

#4

Effect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.

Cornea2026 Mar 01

To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD). Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital. Three treatment zones with different ultraviolet energy levels were planned according to corneal tomography, focusing on the inferior part of the cornea. The control group consisted of 13 conventionally crosslinked eyes. Visual acuity, refraction, and corneal tomography were obtained preoperatively and at 1 month, 6 months, and 1 year after treatment. Corneal tomography showed stability and visual acuity improvement after customized crosslinking in all but 1 patient with a 1-year follow-up. Mean change in logMAR visual acuity was -0.15 ( P = 0.02). However, the improvement in Kmax was not significant (-0.11D, P = 0.8). In the control group, the mean visual acuity did not change (-0.04, P = 0.44), although there were significant changes in keratometry (Kmax -0.81 D, P = 0.02 and Kavg -0.57 D, P = 0.007). Customized corneal crosslinking can be safely used in patients with PMD. No clear advantages over standard crosslinking were observed in this study.

#5

Coincident Pellucid Marginal Degeneration and Fuchsiridocyclitis: a case report.

International journal of surgery case reports2025 Nov

We report a rare coexistence of Pellucid Marginal Degeneration (PMD) and Fuchs' heterochromic iridocyclitis (FHI) in a 40-year-old female. The overlap of corneal ectasia and chronic uveitis created significant diagnostic and surgical challenges, highlighting the importance of individualized planning in complex anterior segment diseases. The patient presented with painless, progressive visual decline in the right eye. Clinical examination revealed inferior corneal thinning, mature cataract, pigmented keratic precipitates, and peripheral anterior synechiae (PAS). Corneal tomography confirmed PMD with a characteristic "crab-claw" pattern. The patient underwent phacoemulsification with posterior chamber intraocular lens implantation. Postoperatively, visual acuity improved, although optic disc cupping and persistent PAS underscored the need for long-term glaucoma surveillance. The coexistence of PMD and FHI is exceptionally rare. PMD complicates surgical planning by affecting keratometric reliability and corneal biomechanics, while FHI contributes to cataract formation, intraocular inflammation, and risk of secondary glaucoma. Multimodal imaging, tailored surgical strategy, and vigilant postoperative follow-up are key to optimizing outcomes. Simultaneous PMD and FHI represent a unique clinical entity requiring comprehensive assessment and individualized management. Tailored surgical planning and vigilant surveillance are essential to preserve vision and mitigate long-term risks.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC141 artigos no totalmostrando 130

2026

Common and Distinct Features in Serum Proteomic Profiles in Keratoconus, Post-Laser Vision Correction Ectasia, and Pellucid Marginal Degeneration.

Investigative ophthalmology &amp; visual science
2025

Coincident Pellucid Marginal Degeneration and Fuchsiridocyclitis: a case report.

International journal of surgery case reports
2026

Acute Corneal Hydrops: A Comprehensive Review of Diagnosis, Treatment, and Outcomes.

Cornea
2026

Update on pellucid marginal degeneration.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2025

Pellucid Marginal Degeneration: A Comprehensive Review of Pathophysiology, Diagnosis, and Management Strategies.

Journal of clinical medicine
2025

Profilometry-Guided Scleral Lenses Improve Visual Acuity and Reduce Ocular Aberrations in Irregular Corneas: A Retrospective Case Series.

Eye &amp; contact lens
2026

Effect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.

Cornea
2024

Differentiation Between Pellucid-Like Keratoconus and Pellucid Marginal Degeneration Using Swept-Source Optical Coherence Tomography.

Cornea
2025

Topographical and functional analysis of different surgical strategies for advanced pellucid marginal degeneration: A long term follow-up.

European journal of ophthalmology
2024

Clinical profile and etiological spectrum of patients presenting with corneal hydrops over a 12-year period.

International ophthalmology
2024

Impact of Scleral Lenses on Visual Acuity and Ocular Aberrations in Corneal Ectasia: A Comprehensive Review.

Journal of personalized medicine
2024

Thermokeratoplasty and amniotic membrane transplantation for refractory corneal hydrops in a patient with pellucid marginal degeneration.

Archivos de la Sociedad Espanola de Oftalmologia
2024

Corneal higher-order aberrations in different types of irregular cornea.

Journal of optometry
2024

Inferior crescent sign in pellucid marginal degeneration.

BMJ case reports
2024

Corneal densitometry changes after femtosecond laser-assisted intracorneal ring segments implantation in keratoconus.

Medical hypothesis, discovery &amp; innovation ophthalmology journal
2024

Crosslinking with UV-A and riboflavin in progressive keratoconus: From laboratory to clinical practice - Developments over 25 years.

Progress in retinal and eye research
2024

Letter Regarding: Case of Progressive Keratoconus With Newly Diagnosed Pellucid Marginal Degeneration After Corneal Cross-Linking.

Cornea
2024

Scleral lens induced short term corneal changes in eyes with Pellucid Marginal Degeneration.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2024

Corneal topography image of bilateral superior pellucid marginal degeneration.

Eye (London, England)
2025

Strategies and Application of Compression Sutures With a Modified Technique for Rapid Resolution of Large (Grade III) Hydrops: A Prospective Interventional Study.

Cornea
2024

Altered Corneal Biomechanics According to the Biomechanical E-Staging in Pellucid Marginal Degeneration.

Cornea
2024

Aberration change after scleral lens wear in eyes with pellucid marginal degenerations.

Indian journal of ophthalmology
2024

Application of a Revised Tissue Saving Protocol for Combined Topography-Guided Photorefractive Keratectomy and Cross-Linking in a Cohort Having Pellucid Marginal Degeneration.

Clinical ophthalmology (Auckland, N.Z.)
2024

Endothelium sparing - Air-assisted wedge resection for the treatment of pellucid marginal degeneration.

Indian journal of ophthalmology
2023

A sequential approach to the management of an advanced case of pellucid marginal degeneration.

American journal of ophthalmology case reports
2023

[A severe unilateral corneal ectasia in children].

Journal francais d'ophtalmologie
2023

Rate of fractional change in corneal tomography parameters in keratoconus using a combination of predictive parameters.

Eye and vision (London, England)
2024

Case of Progressive Keratoconus With Newly Diagnosed Pellucid Marginal Degeneration After Corneal Cross-Linking.

Cornea
2022

Keratoconus in Thai population - a cross-sectional hospital-based study.

Asian biomedicine : research, reviews and news
2023

iOCT-Assisted DSAEK Tamponade for Spontaneous Corneal Perforation with Secondary Bleb Formation in Pellucid Marginal Degeneration.

Klinische Monatsblatter fur Augenheilkunde
2023

Complications in deep anterior lamellar keratoplasty - A retrospective cross sectional interventional analysis in a large series.

Oman journal of ophthalmology
2024

A rare clinical complication in a rare clinical presentation: hydrops and reverse pellucid marginal degeneration.

Clinical &amp; experimental optometry
2023

Short-term visual outcome with sclerocorneal contact lens on irregular cornea.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
2023

Histopathological Changes in Corneal Ectasia.

Klinische Monatsblatter fur Augenheilkunde
2022

Complications in deep anterior lamellar keratoplasty - A retrospective interventional analysis in a large series.

Indian journal of ophthalmology
2022

Corneal Cross-Linking in Pellucid Marginal Degeneration: Evaluation after Five Years.

Journal of current ophthalmology
2022

Ten commandments for biometry in tricky situations.

Indian journal of ophthalmology
2022

Demographic, clinical and tomographic characteristics of pellucid marginal degeneration patients in South Egyptian population.

International ophthalmology
2023

Differential Diagnosis of Keratoconus Based on New Technologies.

Klinische Monatsblatter fur Augenheilkunde
2022

Management of acute corneal hydrops with compression sutures and air tamponade.

Indian journal of ophthalmology
2022

Prevalence of keratoconus in refractive surgery practice population in North Macedonia.

International ophthalmology
2022

Prevalence of Corneal Topographic Patterns in Ectatic Corneal Diseases.

Optometry and vision science : official publication of the American Academy of Optometry
2022

Outcomes of a Single-Segment Intrastromal Corneal Ring in Early Keratoconus and Early Pellucid Marginal Degeneration.

International ophthalmology
2022

[Femtosecond laser-assisted corneoscleral lamellar keratoplasty for peripheral corneal disease].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
2021

Different mRNA expression patterns in keratoglobus and pellucid marginal degeneration keratocytes.

Experimental eye research
2021

Partial-Thickness Intrastromal Lamellar Keratoplasty for Corneal Pellucid Marginal Degeneration.

Cornea
2021

Femtosecond laser-assisted peripheral additive stromal keratoplasty for treatment of primary corneal ectasia: Preliminary outcomes.

Indian journal of ophthalmology
2021

Bilateral pellucid marginal degeneration with oculocutaneous albinism.

BMJ case reports
2021

Posterior Chamber Phakic Intraocular Lens Implantation for Refractive Correction in Corneal Ectatic Disorders: A Review.

Journal of refractive surgery (Thorofare, N.J. : 1995)
2021

Update on corneal collagen crosslinking for ectasia.

Current opinion in ophthalmology
2021

Alternative indications for corneal crosslinking.

Journal of cataract and refractive surgery
2021

[Intracorneal ring segments in keratoconus management].

Journal francais d'ophtalmologie
2021

The effect of scleral lenses on vision, refraction and aberrations in post-LASIK ectasia, keratoconus and pellucid marginal degeneration.

Ophthalmic &amp; physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
2021

Evaluation and management of a spontaneous corneal rupture secondary to pellucid marginal degeneration, using swept-source anterior segment optical coherence tomography.

Oxford medical case reports
2021

[Excimer laser-assisted DALK: a case report from the Homburg Keratoconus Center (HKC)].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
2021

Supra-Descemetic Venting Incision in the Management of Spontaneous Descemet Membrane Detachment in an Old Penetrating Keratoplasty Graft.

Cornea
2021

Spontaneous expulsion of intracorneal ring segment in pellucid marginal degeneration: A case report.

Journal francais d'ophtalmologie
2020

Toric intraocular lens implantation - atypical cases.

Romanian journal of ophthalmology
2020

Topography-guided treatment in regular and irregular corneas.

Indian journal of ophthalmology
2020

Lamellar Keratoplasty for Advanced Keratoconus.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
2020

Tectonic Descemet Stripping Endothelial Keratoplasty for the Management of Corneal Perforation: A Case Series.

Cornea
2021

Comparison of central topographic maps from a swept-source OCT biometer and a Placido disk-dual Scheimpflug tomographer.

Journal of cataract and refractive surgery
2021

Pellucid marginal degeneration versus keratoconus: distinction with wide-field SD-OCT corneal sublayer pachymetry.

The British journal of ophthalmology
2020

A Teenager with Vernal Keratoconjunctivitis and Pellucid Marginal Degeneration, Presenting with Exotropia.

International medical case reports journal
2020

Utility of distant indirect ophthalmoscopy as screening tool in a case of pellucid marginal degeneration.

BMJ case reports
2020

Toll-like receptors as diagnostic targets in pellucid marginal degeneration.

Experimental eye research
2020

Aberrometric outcome of customized toric IOL in cataract with very high corneal astigmatism due to pellucid marginal degeneration.

Journal of cataract and refractive surgery
2021

Ten years experience of corneal collagen cross-linking : An observational study of 6120 cases.

European journal of ophthalmology
2020

Ectasia after keratorefractive surgery: Analysis of risk factors and treatment outcomes in the Indian population.

Indian journal of ophthalmology
2020

Techniques of noncircular corneal transplantation.

Current opinion in ophthalmology
2020

The Correlation between Corneal Findings and Disease Severity in Keratoconus per Scheimpflug Corneal Tomography.

Journal of ophthalmology
2020

Late progressive corneal flattening, haze and visual loss after eccentric crosslinking for Pellucid marginal degeneration.

American journal of ophthalmology case reports
2020

Pellucid marginal degeneration vs inferior keratoconus: why it matters.

Journal of cataract and refractive surgery
2020

Comparison of accelerated CXL alone, accelerated CXL-ICRS, and accelerated CXL-TG-PRK in progressive keratoconus and other corneal ectasias.

Journal of cataract and refractive surgery
2020

[Efficacy of visual rehabilitation of patients with pellucid marginal degeneration fitted with SPOT® scleral contact lenses].

Journal francais d'ophtalmologie
2020

Accelerated Corneal Cross-Linking: Efficacy, Risk of Progression, and Characteristics Affecting Outcomes. A Large, Single-Center Prospective Study.

American journal of ophthalmology
2019

Contact lens fitting after corneal collagen cross-linking.

Oman journal of ophthalmology
2020

[Pellucid marginal degeneration: Role of corneo-scleral contact lens fitting].

Journal francais d'ophtalmologie
2020

Efficacy of visual rehabilitation of patients with pellucid marginal degeneration fitted with SPOT® scleral contact lenses.

Journal francais d'ophtalmologie
2019

Combined Corneal Wedge Resection And Corneal Cross-Linking For Pellucid Marginal Degeneration: A First Report.

Therapeutics and clinical risk management
2020

Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia.

Cornea
2019

Simultaneous Implantation of Refractive Lenticule and Intracorneal Ring Segment in the Management of Pellucid Marginal Degeneration.

Journal of refractive surgery (Thorofare, N.J. : 1995)
2019

Corneal Cross-Linking: An Effective Treatment Option for Pellucid Marginal Degeneration.

Seminars in ophthalmology
2019

Corneal crosslinking for pellucid marginal degeneration.

Journal of cataract and refractive surgery
2019

Yield of Display Modules of Corneal Tomography for Early Diagnosis of Corneal Ectasia.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
2019

Prosthetic replacement of the ocular surface ecosystem for corneal irregularity: Visual improvement and optical device characteristics.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2019

Indications and Surgical Techniques for Corneal Transplantation at a Tertiary Referral Center.

Journal of ophthalmic &amp; vision research
2019

False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2019

Transepithelial Phototherapeutic Keratectomy Followed by Corneal Collagen Crosslinking for the Treatment of Pellucid Marginal Degeneration: Long-term Results.

Cornea
2019

Late detachment of Descemet's membrane after penetrating keratoplasty for pellucid marginal degeneration.

American journal of ophthalmology case reports
2019

Corneal crosslinking in a case with Axenfeld-Rieger syndrome and unilateral pellucid marginal degeneration.

Therapeutic advances in ophthalmology
2019

Pellucid marginal degeneration: Detection, discrimination from other corneal ectatic disorders and progression.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2018

Outcome of deep anterior lamellar keratoplasty patients with intraoperative Descemet's membrane perforation: A retrospective cross-sectional study.

Indian journal of ophthalmology
2019

Terrien marginal degeneration.

Survey of ophthalmology
2018

Visual performance of scleral lenses and their impact on quality of life in patients with irregular corneas.

Arquivos brasileiros de oftalmologia
2018

Corneal biomechanical parameters in pellucid marginal degeneration.

Journal of current ophthalmology
2018

Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration.

Journal of current ophthalmology
2018

Candida parapsilosis Infection After Crescentic Lamellar Wedge Resection in Pellucid Marginal Degeneration.

Turkish journal of ophthalmology
2019

Surgical management of peripheral corneal thinning disorders.

Survey of ophthalmology
2018

Peripheral Corneal Hydrops Secondary to Pellucid Marginal Degeneration Managed With a Manually Dissected Semicircular Endothelial Keratoplasty Lenticule.

Cornea
2018

Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report.

BMC ophthalmology
2018

EyePrintPRO therapeutic scleral contact lens: indications and outcomes.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2018

The Impact of Scleral Contact Lens Vault on Visual Acuity and Comfort.

Eye &amp; contact lens
2018

Crab claw pattern on corneal topography: pellucid marginal degeneration or inferior keratoconus?

Eye (London, England)
2017

Effect of Time on Scleral Lens Settling and Change in Corneal Clearance.

Optometry and vision science : official publication of the American Academy of Optometry
2017

[Results of corneal crosslinking for pellucid marginal corneal degeneration].

Vestnik oftalmologii
2018

Refractive and Corneal Aberrometric Changes After Crescentic Lamellar Wedge Resection in Pellucid Marginal Degeneration.

Eye &amp; contact lens
2017

Indications and visual outcomes of intrastromal corneal ring segment implantation in a large patient series.

Clinics (Sao Paulo, Brazil)
2017

Longitudinal Outcomes of U.S. Air Force Pilot Applicants With Waivered Astigmatism.

Military medicine
2016

Short-term result of collagen crosslinking in pellucid marginal degeneration.

Advanced biomedical research
2016

Surgical Treatment of Corneal Ectasia with Motowa's Trephine and Selective Suturing Technique.

Middle East African journal of ophthalmology
2017

Corneal collagen cross-linking. A review of its clinical applications.

Archivos de la Sociedad Espanola de Oftalmologia
2016

Clinical outcomes of scleral Misa lenses for visual rehabilitation in patients with pellucid marginal degeneration.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2016

Prevention of Iatrogenic Keratectasia.

Klinische Monatsblatter fur Augenheilkunde
2016

Corneal perforation during scleral indentation in a patient with pellucid marginal degeneration.

Indian journal of ophthalmology
2016

Tear Mediators in Corneal Ectatic Disorders.

PloS one
2016

Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration.

Cornea
2016

Characterization of Ocular Biomechanics in Pellucid Marginal Degeneration.

Cornea
2016

Comparison of intraocular pressure post penetrating keratoplasty vs Descemet's stripping endothelial keratoplasty.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2016

Sliding Keratoplasty Followed by Transepithelial Iontophoresis Collagen Cross-linking for Pellucid Marginal Degeneration.

Journal of refractive surgery (Thorofare, N.J. : 1995)
2015

Full-Ring Intracorneal Implantation in Corneas With Pellucid Marginal Degeneration.

Iranian Red Crescent medical journal
2016

Scleral contact lenses in the management of pellucid marginal degeneration.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2015

Scleral lens for keratoconus: technology update.

Clinical ophthalmology (Auckland, N.Z.)
2015

Clinical performance of KeraSoft(®) IC in irregular corneas.

Clinical ophthalmology (Auckland, N.Z.)
2016

Management of advanced corneal ectasias.

The British journal of ophthalmology
2015

Corneal Hydrops in Pellucid Marginal Degeneration: A Case Series.

Case reports in ophthalmology
2015

Corneal Collagen Cross-Linking in Pellucid Marginal Degeneration: 2 Patients, 4 Eyes.

Case reports in ophthalmological medicine
2015

Corneal collagen crosslinking in keratoconus and other eye disease.

International journal of ophthalmology
2015

Outcome of complete intrastromal ring implantation using femtosecond laser in pellucid marginal degeneration.

Eye (London, England)
2015

Mini-incision cataract surgery and toric lens implantation for the reduction of high myopic astigmatism in patients with pellucid marginal degeneration.

Eye (London, England)
Ver todos os 141 no EuropePMC

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Common and Distinct Features in Serum Proteomic Profiles in Keratoconus, Post-Laser Vision Correction Ectasia, and Pellucid Marginal Degeneration.
    Investigative ophthalmology &amp; visual science· 2026· PMID 41810891mais citado
  2. Acute Corneal Hydrops: A Comprehensive Review of Diagnosis, Treatment, and Outcomes.
    Cornea· 2026· PMID 41236420mais citado
  3. Update on pellucid marginal degeneration.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie· 2026· PMID 41212223mais citado
  4. Effect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.
    Cornea· 2026· PMID 40073226mais citado
  5. Coincident Pellucid Marginal Degeneration and Fuchsiridocyclitis: a case report.
    International journal of surgery case reports· 2025· PMID 41332050mais citado
  6. Prevalence and Risk Factors for Keratoconus in Young Adults Assessed with Tomography and Corneal Biomechanics: A Prospective Cross-Sectional Study.
    Ophthalmol Sci· 2026· PMID 41907381recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:137672(Orphanet)
  2. MONDO:0015298(MONDO)
  3. GARD:11895(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q2059804(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Degeneração marginal pelúcida
Compêndio · Raras BR

Degeneração marginal pelúcida

ORPHA:137672 · MONDO:0015298
CID-10
H18.7 · Outras deformidades da córnea
CID-11
Ensaios
1 ativos
MedGen
UMLS
C0339288
EuropePMC
Wikidata
Papers 10a
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