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Doença sindrômica do sistema lacrimal
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A doença de Sjögren (DSj), anteriormente conhecida como síndrome de Sjögren, é uma doença autoimune crônica que afeta principalmente as glândulas exócrinas do corpo, em particular as glândulas lacrimais e salivares. Sintomas comuns incluem boca seca e olhos secos, e frequentemente afeta gravemente outros sistemas orgânicos, como os pulmões, os rins e o sistema nervoso.

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Últimos 10 anos200publicações
Pico2026160 papers
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2025Hoje · 2026
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Publicações mais relevantes

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Timeline de publicações
0 papers (10 anos)
#1

Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation.

Investigative ophthalmology & visual science2026 Mar 02

Ocular surface microbiota (OSM) dysbiosis is associated with dry eye disease (DED), but the underlying mechanisms remain poorly understood. This study investigated the role of lipoteichoic acid (LTA), a Gram-positive bacterial product, in DED pathogenesis. A cross-sectional study was conducted involving 277 participants to analyze OSM composition via 16S rRNA sequencing and quantify tear LTA levels. In vitro experiments using human corneal epithelial cells (HCE-T) and in vivo mouse models were used to explore LTA-induced inflammation. The involvement of Toll-like receptor 2 (TLR2) and platelet-activating factor receptor (PAFR) was assessed using siRNAs and the PAFR antagonist Apafant. Patients with DED showed functional enrichment in LTA synthesis-related pathways in their OSM. Tear LTA levels were significantly elevated in patients with DED and correlated positively with disease risk and clinical severity. Mechanistically, LTA activated p38 MAPK and NF-κB signaling pathways via TLR2 and PAFR, upregulating pro-inflammatory cytokine expression. In mice, topical LTA administration induced corneal epithelial damage, reduced tear secretion, and caused histopathological changes. Treatment with Apafant significantly alleviated LTA-induced corneal inflammation, improved tear secretion, and preserved epithelial integrity. Our findings establish a mechanistic link between OSM-derived LTA and DED. LTA promotes ocular surface inflammation and dysfunction through TLR2 and PAFR signaling, suggesting that targeting microbial products or their receptors, such as PAFR, may offer a novel therapeutic strategy for DED.

#2

Prevalence and influencing factors of dry eye syndrome among pilots: A survey study.

PloS one2026

Dry eye syndrome (DES) is a prevalent ocular condition that significantly impacts affected individuals' quality of life and occupational performance. This study investigates the prevalence and contributing factors of DES among pilots, which is a group particularly susceptible to environmental and occupational stressors. A descriptive, observational study was conducted, which involved 794 pilots. Based on the severity of DES, these pilots were assigned into mild, moderate and severe groups. Data was collected through surveys, and analyzed using multiple linear regression, in order to determine the relationship between the DES scores and potential influencing factors. The study revealed that all pilots included in the present study were affected by DES, in which 88.40% of pilots experienced moderate DES and 11.60% of pilots reported severe DES. After adjusting for other covariates in the model, the multivariate analysis revealed that eyelid diseases, ocular surface disease, poor sleep quality, and fatigue were statistically significant and positively correlated to higher DES scores (p < 0.05), while residing in the southern region and engaging in physical activities were statistically significant and negatively correlated to the DES scores (p < 0.05). The high prevalence of DES in pilots highlights the urgent need for tailored occupational health interventions. Strategies to mitigate DES risk should include promoting regular physical exercise, improving sleep quality, and addressing fatigue. Future research should prioritize longitudinal studies to establish causal relationships and develop targeted management approaches for this high-risk occupational group.

#3

Conjunctival Impression Cytology and Dry Eye Parameters in Migraine Patients.

Neurology India2026 Mar 01

Migraine is a chronic neurovascular inflammatory disorder involving complex mechanisms such as trigeminovascular system activation and neuroinflammation. In addition to headache, migraine may be associated with ophthalmic manifestations that are often overlooked. Dry eye disease is a multifactorial inflammatory disorder of the ocular surface characterized by tear film instability. Recent evidence suggests a potential association between migraine and dry eye, possibly through shared neurovascular and inflammatory pathways. In this study, it was aimed to compare ocular surface changes and dry eye parameters between migraine patients and healthy individuals. The participants of the present cross-sectional comparative study are 30 migraine patients and 31 age and gender matched healthy individuals. The demographic and clinical data of migraine patients were recorded. Ocular surface changes were evaluated using Schirmer I test, tear break-up time (TBUT), Ocular Surface Disease Index (OSDI) scores and conjunctival impression cytology (CIC) grades were assessed and results were compared between the two groups. CIC degrees of the migraine patients were higher than the control group (p<0.001). CIC assessment of the migraine group revealed that ten patients (33.3%) were of grade II-III, whereas the CIC assessment of two (6.5%) participants in the control group was grade II. Grade III CIC was not determined in the control group. TBUT in the migraine group was lower compared to the control group (p=0.023) and Schirmer I was (p=0.013) lower and OSDI score higher (p<0.001). In the migraine group, there was an inverse correlation between CIC grade, Schirmer I test (p=0.001, p=-0.559) and TBUT (p<0.001, p=-0.778). Objective signs and subjective symptoms of dry eye are common in patients with migraine. Abnormal CIC evaluation findings such as morphological changes in the bulbar conjunctiva, goblet cell loss, and squamous metaplasia suggest the presence of inflammation. These findings too, support the hypothesis that dry eye and changes in the ocular surface may play a role in the pathogenesis of migraine.

#4

Therapeutic efficacy and safety of a multi-wavelength LED irradiation device in a rat model of meibomian gland dysfunction.

Lasers in medical science2026 Mar 11

This study aimed to evaluate the therapeutic efficacy and ocular safety of a multi-wavelength (680 nm, 780 nm, 830 nm) LED irradiation device in a rat model of meibomian gland dysfunction (MGD)-induced dry eye disease (DED). A total of 34 male SD rats were randomly assigned to eight experimental groups, including a normal control group, an MGD induction group, and various treatment groups (LED irradiation, hyaluronic acid, cyclosporine, thermal therapy, and combination therapy). MGD was induced by CFA injection. LED irradiation was administered daily from day 8 to day 22. The clinical ocular assessments included the following: tear break-up time (TBUT), eyelid swelling score, fluorescein corneal staining (FCS), and eyelid telangiectasia. Immunohistochemistry (IHC) analyses of IL-1β, IL-6, and TNF-α were conducted in the cornea, conjunctiva, meibomian glands, and retina. To assess retinal safety, a TUNEL staining procedure was performed. The LED and combination treatment groups showed significant enhancements in TBUT and reductions in FCS, eyelid swelling, and telangiectasia scores in comparison to the MGD group (p < 0.05). In-depth analysis of the data sets revealed a significant decrease in the expression of inflammatory cytokines among the treatment groups. Notably, the expression of IL-1β and IL-6 was significantly reduced in both the LED and combination groups.

#5

A Droplet Evaporimeter for Evaluating Eye Care Formulations.

Translational vision science &amp; technology2026 Mar 02

This study explores the development and application of a convenient droplet-based evaporimeter system as a research tool to investigate the evaporation of lubricating eye drop formulations and potentially other ophthalmic applications. The evaporimeter integrates a goniometer with an environmental control system, allowing for precise test solution adjustment and a wide range of environmental settings. To verify the system design, pure water evaporation was conducted under various environmental conditions. Measured water evaporation rates aligned with the theoretical kinetic mass-transfer model. Evaporation evaluations were performed under conditions simulating the ocular surface in typical indoor environments. This study compared the evaporative flux of three baseline solutions and various commercial lubricating eye drop formulations. Phosphate-buffered saline (PBS) had an evaporative flux similar to water, whereas simulated artificial tear solution (ATS), containing tear components, exhibited a lower evaporative flux. Among the tested eye drops, Systane Pro Preservative Free demonstrated the greatest reduction in evaporative flux, highlighting a potential synergistic effect between mineral oil and hyaluronic acid. An advanced evaporation evaluation system designed for in vitro and ex vivo research has been established to provide a rapid method with tunable sample/environment conditions to assess evaporative flux from eye drop formulations. This study enables future work to investigate eye drop formulations and their interactions with tear components to better understand their effects on reducing tear evaporation in dry eye. This work provides a reliable method to evaluate the effectiveness of eye drop formulations in reducing tear evaporation, which is essential for managing dry eye.

Publicações recentes

Ver todas no PubMed

📚 EuropePMCmostrando 200

2026

[Management of ocular adverse events associated with antibody-drug conjugates in the treatment of solid tumors: a consensus statement from Chinese experts (2025 edition)].

Zhonghua zhong liu za zhi [Chinese journal of oncology]
2026

Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation.

Investigative ophthalmology &amp; visual science
2026

Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease.

Journal of immunology research
2026

A Lip Fixation Device Facilitates Labial Salivary Gland Biopsy for Sjögren's Disease.

Journal of visualized experiments : JoVE
2026

Perfluorohexyloctane eye drops in treating dry eye disease associated with meibomian gland dysfunction: a post hoc analysis by baseline severity.

International ophthalmology
2026

Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren's disease.

Frontiers in immunology
2026

Primary Sjögren's syndrome-associated immune thrombocytopenia: from pathogenesis to treatment.

Frontiers in immunology
2026

[Dry eye disease in young and middle-aged adults].

Vestnik oftalmologii
2026

Prevalence and influencing factors of dry eye syndrome among pilots: A survey study.

PloS one
2026

Risk of Cancer in Patients With Primary Sjögren's Disease and Their Relatives.

International journal of rheumatic diseases
2026

[Thumbtack needling combined with sodium hyaluronate eye drops for moderate-to-severe dry eye].

Zhongguo zhen jiu = Chinese acupuncture &amp; moxibustion
2026

Immunotherapy-induced sialadenitis: sjögren's syndrome or a new sialadenitis.

Frontiers in immunology
2026

POBS Relieves Antigen-Induced Experimental Sjögren's Disease by Regulating B Lymphocyte Subsets via CXCL13/CXCR5 Signaling Pathway.

IUBMB life
2026

Conjunctival Impression Cytology and Dry Eye Parameters in Migraine Patients.

Neurology India
2026

[Determination of vitamin A and vitamin E in human tear by liquid chromatography-tandem mass spectrometry and analysis of their relationship with dry eye].

Se pu = Chinese journal of chromatography
2026

Immunophenotypic Stratification of Primary Sjögren's Syndrome Reveals Distinct Lymphocyte Profiles and Clinical Manifestations.

Journal of immunology research
2026

Therapeutic efficacy and safety of a multi-wavelength LED irradiation device in a rat model of meibomian gland dysfunction.

Lasers in medical science
2026

Effect of a propylene-glycol-hydroxypropyl guar nanoemulsion on symptoms and ocular surface parameters in patients with evaporative dry eye.

Arquivos brasileiros de oftalmologia
2026

Quantitative assessment of tear film function and meibomian gland morphology in newly diagnosed atopic dermatitis.

Arquivos brasileiros de oftalmologia
2026

The role of meibomian gland morphological alterations in the development of dry eye disease in type 2 diabetes.

Arquivos brasileiros de oftalmologia
2026

Hybrid nanogel system of quercetin-loaded squalene NLCs with zinc-HA network for dry eye syndrome.

International journal of biological macromolecules
2026

A Droplet Evaporimeter for Evaluating Eye Care Formulations.

Translational vision science &amp; technology
2026

Evaluation of the Impact of Cordyceps cicadae Mycelium on Vision Health: A Cohort Study.

International journal of medical sciences
2026

Ocular social jetlag: a driver of immune-metabolic dysfunction in dry eye disease.

Frontiers in immunology
2026

Simultaneous quantification of lifitegrast and Rebamipide in hydrogel-based contact lenses using spectroscopic method.

International ophthalmology
2026

mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review).

International journal of molecular medicine
2025

Dry Eye in Post-menopausal Women Visiting Community Eye Centre: An Observational Study.

JNMA; journal of the Nepal Medical Association
2026

Impact of socioeconomic deprivation on risk and disease activity of Sjögren's disease.

RMD open
2026

Pulmonary light chain deposition disease secondary to Sjögren disease: a case report.

Frontiers in immunology
2026

Therapeutic effects of Chelidonium majus on ocular surface ınflammation and tear film homeostasis in a benzalkonium chloride-ınduced rat model of dry eye disease.

International ophthalmology
2026

CL-EVLPs Promote Corneal Repair in a BAC-Induced Corneal Injury Model via Ocular Microenvironment Reconstruction.

Investigative ophthalmology &amp; visual science
2026

Cross-linked carboxymethyl cellulose and silk proteins for dry eye disease management and corneal wound healing: in vivo and in vitro results.

European review for medical and pharmacological sciences
2026

Sjögren Syndrome Associated Limbic Encephalitis and Its Longitudinal Brain FDG PET Manifestations.

Clinical nuclear medicine
2026

Correlation between ocular surface characteristics and tear lymphotoxin-alpha in patients with type 2 diabetes mellitus of different courses.

International ophthalmology
2026

Soluble Fas Ligand, an overlooked target of therapy in dermatological and non-dermatological conditions.

The Journal of dermatological treatment
2026

A novel murine model of Sjögren's disease using lacrimal autoantigen.

Frontiers in immunology
2025

[Establishment and efficacy evaluation of a risk prediction model for lymphoma in patients with Sjögren's syndrome].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
2026

T cells co-expressing high levels of CD29 and CD99 show increased cytotoxic potential and are upregulated in Sjögren's disease.

Journal of immunology (Baltimore, Md. : 1950)
2026

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway.

Frontiers in bioscience (Landmark edition)
2026

Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.

In vivo (Athens, Greece)
2026

Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival Organoids.

Investigative ophthalmology &amp; visual science
2026

Tear-Based Oxidative Stress Biomarkers in Primary and Sarcoidosis-Associated Dry Eye Disease.

International journal of molecular sciences
2026

Analysis of CCR9, CXCR5 and ICOS in Circulating Follicular Helper T Cell-like Populations in Sjögren's Disease.

International journal of molecular sciences
2026

Study protocol for a randomised controlled trial to evaluate the prophylactic efficacy of combined intense pulsed light (IPL) and low-level light therapy (LLLT) in preventing laser corneal refractive surgery-induced dry eye: the Treat Eye Before Laser induced Dry (TEBeLiD) study.

BMJ open
2026

Fortified Long-acting Ocular Gel Laden with Nanoformulated Dexamethasone for Dry Eye Therapy.

AAPS PharmSciTech
2026

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy.

Experimental &amp; molecular medicine
2025

Global prevalence of dry Eye: A systematic review and meta-analysis.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Prevalence and predictors of dry eye syndrome among the young population in Jordan: A cross-sectional survey study.

Medicine
2026

Short-term efficacy of intense pulsed light in the treatment of hordeolum: A prospective cohort study.

Medicine
2026

Distinct immunological features characterize early-onset primary Sjögren's disease.

Rheumatology (Oxford, England)
2026

Surgical removal of Waldeyer's ring and long-term risk of Sjögren's syndrome: a population-based cohort study investigating the mucosal immune link.

Frontiers in immunology
2026

Proanthocyanidins inhibit the inflammation response of dry eye by regulating IRAK4/JAK1/STAT1 signaling pathway.

Experimental eye research
2026

Evolution and prospects for the definition of clinically useful endpoints in Sjögren disease.

Current opinion in immunology
2026

Single-Cell Transcriptomic Analysis Reveals ISG15 as a Key Regulator of Macrophage-Mediated Inflammation Driving Primary Sjögren's Syndrome Progression.

Critical reviews in immunology
2026

Altered Carnitine Homeostasis Modulates Hyperosmolarity-Induced Mitochondrial Dysfunction and Lipotoxicity in Human Corneal Epithelial Cells.

Investigative ophthalmology &amp; visual science
2026

Identification of molecular diagnostic markers and potential therapeutic drugs for Sjögren's syndrome.

Scientific reports
2026

Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.

Cell reports. Medicine
2026

Serological Stratification by Anti-Ro52 and Anti-Ro60 Profiles Reveals Distinct Systemic Phenotypes in Primary Sjögren's Disease.

Seminars in arthritis and rheumatism
2026

Hormonal transitions across the lifespan shape susceptibility to Sjogren's disease.

Rheumatology (Oxford, England)
2026

The Impact of Advanced Surface Moisturizing Technologies on Contact Lens Comfort in Digital Platform Users.

Turkish journal of ophthalmology
2026

The Intracellular C5a-mtC5aR1 Axis Promotes Necroptosis in Dry Eye Through DRP1-Mediated Mitochondrial Dysfunction.

Investigative ophthalmology &amp; visual science
2026

T cells in Sjögren's disease: update on their role in salivary gland pathogenesis and treatment.

Current opinion in immunology
2026

Lacrimal drainage system involvement in CHARGE syndrome: a two-case report.

Orbit (Amsterdam, Netherlands)
2026

Prevalence and severity of dry eye disease among ophthalmologists, optometrists, and nurses: a cross-sectional questionnaire-based survey.

International ophthalmology
2026

Evaluation of blepharoptosis, meibomian gland morphology, and dry eye parameters in older individuals with sarcopenia: a case-control study.

International ophthalmology
2026

Developments in the therapeutic landscape for dry eye.

Expert opinion on pharmacotherapy
2026

A Case of Ganglionopathy Presenting with Hyperkinetic Movements.

Tremor and other hyperkinetic movements (New York, N.Y.)
2026

Clusterin reverses epitheliopathy, reduces inflammation, and restores goblet cells and corneal nerves in a mouse model of autoimmune dry eye.

Scientific reports
2026

The role of TSPO in regulating hyperosmolarity-induced inflammatory response in human corneal epithelial cells via PPARγ.

Experimental eye research
2026

Minor salivary gland biopsy in Sjogren's disease: a diagnostic and prognostic tool toward precision medicine.

Current opinion in immunology
2026

FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren's syndrome via fatty acid oxidation-dependent oxidative phosphorylation.

Arthritis research &amp; therapy
2026

Benchmark evaluation of video large language models in quality assessment of science popularization videos for dry eye.

Scientific reports
2026

Animal-based experimental models in dry eye research: Current approaches and limitations.

Experimental eye research
2026

Skin Microbiome Profiling in Patients with Primary Sjögren Disease Compared to Healthy Individuals.

Journal of microbiology and biotechnology
2026

Urinary CD4+ T helper cells are a potential biomarker for tubulointerstitial nephritis in Sjögren's disease.

Scientific reports
2025

Analysis of tear inflammatory proteins following Low-Level light therapy in dry eye disease patients.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren's disease.

Journal of molecular medicine (Berlin, Germany)
2026

Mitigation of Oxidative Stress Pathways in the Diabetic Cornea and Lacrimal Glands Contributes to the Rapid Reversal of Diabetic Dry Eye by Naltrexone.

Investigative ophthalmology &amp; visual science
2026

JAK inhibitor tofacitinib alleviates secretory dysfunction and Th17/Treg imbalance in a Sjögren's disease murine model.

Annals of medicine
2026

Combination of 0.09% cyclosporine and intense pulsed light (IPL) therapy for the treatment of dry eye disease in symptomatic contact lens wearers: study protocol for a sham-controlled randomized clinical trial.

Trials
2026

Modified Autologous Conditioned Serum (mACS) demonstrates the neuroprotective effect in the Benzalkonium chloride (BAK)-induced murine dry eye model.

Experimental eye research
2026

Alternative splicing signatures correlate with disease severity and clinical subtypes in primary Sjögren's syndrome.

Genomics
2026

Elevated serum MMP3 levels as a potential biomarker of disease activity in primary Sjögren's syndrome: a prospective observational study.

Clinical rheumatology
2026

Biologic therapy is associated with reduced ocular disease in psoriasis: a real-world study.

Eye (London, England)
2026

UCMSC-derived exosomes ameliorate dry eye disease pathogenesis by modulating neutrophils on Th17/Treg balance.

Scientific reports
2026

[Analysis of the clinical characteristics of dry eye patients with type 2 diabetes mellitus at different disease durations].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
2026

[Pay attention to blepharospasm and dry eye].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
2026

Muscarinic 3 receptor antibodies in Sjögren's disease: Evaluating assay variability and detection methods.

Journal of immunological methods
2026

The Role of the Tear Film in Refraction: Quantitative Evaluation Before and After Rexon-Eye Therapy.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
2026

Impact of contact lenses on the ocular surface microbiome, tear proteome, and dry eye disease.

Microbiology spectrum
2026

β-Adrenergic Signaling Contributes to Circadian and Lipid Dysregulation in Meibomian Glands During Chronic Psychological Stress.

Investigative ophthalmology &amp; visual science
2026

Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled trial.

Lasers in medical science
2026

[Research progress in diagnosis and treatment of non-tumorous salivary gland diseases].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
2026

Molecular landscape connecting complications of dry eye disease: mechanisms, therapeutic targets, biomarkers, and future innovations.

International ophthalmology
2025

Intervention with cyclosporine A stabilizes tear film and relieves asthenopia in mild dry eye with short fluorescein tear break-up time : A randomized controlled trial.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2025

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren's syndrome pregnancy with literature review.

Frontiers in immunology
2026

Impact of Xerostomia on dental treatment outcomes: a systematic review.

BMC oral health
2026

Wild chrysanthemum essential oil alleviates dry eye disease by inhibiting NF-κB-mediated inflammation.

Inflammopharmacology
2026

Differential Expression of Tear Lymphotoxin-Α, Immunoglobulin E, and Matrix Metalloproteinase-9 in Allergic Conjunctivitis-Associated Dry Eye.

Current eye research
2026

Chest muscle area, spleen density, CD4 + T%, and C4 to predict the development of interstitial lung disease in patients with Sjögren's syndrome: a clinical prediction model.

Clinical rheumatology
2026

Patients' perspectives of living with Sjögren disease: A systematic review of qualitative studies from the OMERACT Sjögren disease working group.

Seminars in arthritis and rheumatism
2026

The impact of obstructive sleep apnea syndrome on corneal sensitivity and dry eye parameters: a comprehensive analysis.

International ophthalmology
2025

Anti-NMDA receptor encephalitis unmasking Sjögren's disease: a case report and literature review.

Frontiers in immunology
2026

Real-World Transition to a Preservative-Free Fixed Combination of Dorzolamide/Timolol: Impact on the Ocular Surface Microenvironment, Safety, Tolerability, and Efficacy.

Medicina (Kaunas, Lithuania)
2026

Impact of Dry Eye Disease and Lipid-Containing Artificial Tears on Keratometric Reproducibility and Intraocular Lens Calculation in Cataract Patients.

Medicina (Kaunas, Lithuania)
2026

Asymmetric Tear Secretion: Can This Disorder Help in Suspecting Gastroesophageal Reflux Disease and in Managing Sjögren's Disease? A Pilot Study.

Medicina (Kaunas, Lithuania)
2025

Oral Manifestations of Sjögren's Syndrome: Recognition, Management, and Interdisciplinary Care.

Medicina (Kaunas, Lithuania)
2026

The H159Y Variant of the BAFF-R Gene (TNFRSF13C) Is Unrelated to the Risk of Developing Systemic Lupus Erythematosus and Sjögren's Disease in a Mexican Population.

International journal of molecular sciences
2026

From Proteome to miRNome: A Review of Multi-Omics Ocular Allergy Research Using Human Tears.

International journal of molecular sciences
2026

Variants in IRF5 Increase the Risk of Primary Sjögren's Syndrome in the Mexican Population.

International journal of molecular sciences
2026

A Narrative Review of Salivary Gland Extracellular Matrix and Sjögren's Syndrome: Research Status and Future Prospects.

Biomolecules
2025

Tear meniscus height in the Beijing Adult Dry Eye Cohort study (ADEC).

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Application of umbilical cord mesenchymal stem cell lysate in dry eye syndrome and retinal injury.

International ophthalmology
2026

Seasonal variations and environmental factors associated with allergic ocular surface disease: A prospective observational study of clinical presentation patterns in South Asian region.

International ophthalmology
2025

Corneal surface temperature dynamics with lipid vs non-lipid artificial tears during sustained eye opening: a crossover study.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Mucus fishing syndrome: clinical spectrum and update on its multifactorial pathogenic mechanisms.

International ophthalmology
2026

Dry Eye Disease After Ocular or Systemic Infection: A Systematic Review.

Eye &amp; contact lens
2026

Neurological and paraclinical features differentiating Systemic lupus erythematosus, Sjögren's disease, and neuromyelitis optica spectrum disorders.

Multiple sclerosis and related disorders
2026

Immune thrombocytopenia in patients with connective tissue disease.

Clinical rheumatology
2026

Patient-Reported Symptoms Versus Clinician-Measured Signs to Distinguish Sjogren's in Patients With Dry Eye.

Translational vision science &amp; technology
2026

Prediction of foetal atrioventricular conduction using maternal disease, treatment and anti-Ro/La autoantibody levels.

Rheumatology (Oxford, England)
2026

Risk factors for disease progression in primary Sjögren's syndrome patients with low disease activity: a multicenter registry-based cohort study.

Clinical rheumatology
2026

Engineered CGRP Eye Drops Restore Tear Secretion via TRPM8-SSN Circuitry in a Postrefractive Surgery Mouse Model.

Investigative ophthalmology &amp; visual science
2025

Corneal sensitivity in new silicone hydrogel contact lens wearers.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Impact of Diabetic Peripheral Neuropathy on Corneal Sensitivity and Ocular Surface.

Ophthalmic research
2026

Non-Invasive Break-Up Time in the Beijing Adult Dry Eye Cohort Study (ADEC): A Cross-Sectional Baseline Analysis.

Journal of epidemiology and global health
2026

Comparison of clinical and inflammatory markers for dry eye disease following phacoemulsification and manual small incision cataract surgery (MSICS).

Scientific reports
2026

Results of a Randomized, Double-Masked, Placebo-Controlled Phase 1/2 Study of a TRPV1 Antagonist SJP-0132 in Participants With Dry Eye Disease.

American journal of ophthalmology
2025

The Clinical Effect of Combined Needle-Embedding Therapy for Patients with Lifestyle-Related Dry Eye Disease.

Journal of visualized experiments : JoVE
2025

Polyclonal hypergammaglobulinemia, infiltration of the salivary glands, lymphadenopathy, and kidney damage - Mikulicz's disease, Sjögren's syndrome, or Castleman's disease? Case report and overview of differential diagnosis and treatment.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
2026

Central nervous symptoms as the prominent manifestation of Sjögren's disease (SjD): a case report.

BMC neurology
2026

Deciphering the molecular landscape of Sjögren's disease, mucosa-associated lymphoid tissue lymphoma, and thyroid cancer: unraveling the complexities of disease mechanisms and diagnostic biomarkers.

Clinical rheumatology
2026

Silicone Punctal Plugs as a Significant Risk Factor for Iatrogenic Endophthalmitis: A Case Report.

Ocular immunology and inflammation
2026

Comparative efficacy of pranoprofen with sodium hyaluronate or polyvinyl alcohol in postoperative dry eye and corneal endothelial function.

Pakistan journal of pharmaceutical sciences
2026

Safety and effectiveness of rituximab therapy in Sjögren's disease: a PORTRESS - the Portuguese registry of Sjögren's disease-based study.

Clinical rheumatology
2026

Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study.

JMIR research protocols
2025

[Effects and Mechanisms of Yangyin Yiqi Huoxue Formula on the Oral Microecology in Sjögren's Syndrome Model Mice].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
2026

New autoantibodies in Sjögren's disease.

Current opinion in immunology
2025

FGF10/IGSF3 Variants in Bony Congenital Nasolacrimal Duct Obstruction: A Genotype-Phenotype Study of Syndromic Versus Isolated Disease.

Investigative ophthalmology &amp; visual science
2025

Degradation of Elastic Fiber Triggers Lacrimal Gland Dysfunction in Marfan Syndrome Mice.

Investigative ophthalmology &amp; visual science
2025

Ocular Surface Disorders in ICU Patients: Evidence-Based Nursing Prevention Strategies.

Translational vision science &amp; technology
2026

Biophysical Interactions of Silicon Quantum Dots With Human Tears and Dry Eye Drops: A Langmuir Trough Study.

Translational vision science &amp; technology
2026

Comprehensive Analysis of the Conjunctival Sac Microbiome in Patients With Evaporative Dry Eye and Mixed Dry Eye.

Translational vision science &amp; technology
2026

High-safety tacrolimus nanoemulsion for dry eye disease treatment through anti-oxidant and anti-inflammatory effects.

Nanoscale
2026

Sex differences in primary Sjögren's disease: prognostic impact on mortality and cancer.

Biology of sex differences
2025

Impact of lipid degradation and tear film stability on silicone hydrogel contact lens wearers with discomfort.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Ocular findings in children with Juvenile Systemic Lupus Erythematosus in a Brazilian Tertiary-Care Hospital.

Lupus
2026

Unveiling dry eye with autoimmune features (DEAF): insights from a prospective longitudinal study.

Clinical rheumatology
2026

Spotlight on Sjögren's: a patient perspective on burden of illness and unmet needs - results from a real-world survey.

RMD open
2026

Meibomian Gland Dysfunction and Dry Eye Disease in Mucous Membrane Pemphigoid Patients With and Without Ocular Complaints: A Comparative Study.

Ocular immunology and inflammation
2026

Qiju Dihuang Pill modulates complement system in age-related dry eye disease: Tripartite validation through clinical-omics-animal integration.

Journal of ethnopharmacology
2026

Quantitative immunoassays of matrix Metalloproteinase-9 in tears using a contact Lens.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
2026

The immune cell landscape analysed by imaging mass cytometry in the muscle of patients with inclusion body myositis associated or not with Sjögren's disease.

Rheumatology (Oxford, England)
2026

The role of stromal cell immunobiology in understanding and managing Sjögren's disease.

Current opinion in immunology
2025

Establishment of Autoreactive CD4+CD8+ T Cell Hybridomas from Sjögren's Disease Model, SATB1 Conditional Knockout Mice.

International journal of molecular sciences
2025

Predicted T-Cell and B-Cell Epitopes of NIS: Where Do Sjögren's Syndrome and Hashimoto's Thyroiditis Converge?

International journal of molecular sciences
2025

Fatal West Nile Encephalomyelitis in a Young Woman with Hypoparathyroidism and Sjögren's Syndrome. Molecular Insights into Viral Neuro-Invasivity.

International journal of molecular sciences
2026

Markers predicting lymphoma development in Sjögren disease: current status and future perspectives.

Current opinion in immunology
2026

Anterior Scleral Thickness in Rheumatoid Arthritis and Sjögren's Syndrome: A Comparative Analysis.

Ocular immunology and inflammation
2026

Extracellular superoxide dismutase 3 (SOD3) attenuates non-Sjögren and Sjögren syndrome dry eyes in animal models.

European journal of pharmacology
2026

Deciphering Sjögren's disease: New insights and perspectives extend from advanced omics approaches and immunology.

Journal of autoimmunity
2026

Polystyrene and polyvinyl chloride microplastics exposure induces ocular surface inflammation by causing mitochondrial damage and lipid metabolic disruption.

Journal of hazardous materials
2026

Association between Traditional Chinese Medicine patterns and dry eye in the Chinese population: A cross-sectional study.

Medicine
2026

Sjögren's disease metabolome reveals biomarker signatures to characterise patients and assess disease activity.

RMD open
2026

Evaluation of the ocular surface in rheumatoid arthritis patients on conventional synthetic disease-modifying antirheumatic drugs.

Journal francais d'ophtalmologie
2026

Corneal Fluorescein Staining in FDA-Reviewed Dry Eye Registrational Clinical Trials: Evidence of Limited Endpoint Responsiveness.

Ophthalmic research
2026

Relapse risk after glucocorticoid withdrawal in stable Sjögren's disease-associated interstitial lung disease: a retrospective cohort study in China.

Clinical rheumatology
2026

Elevated IL-8 and abnormal lymphocytes in pediatric primary Sjögren's syndrome: a single-center study.

European journal of medical research
2025

Frailty and associated risk factors in patients with Sjögren's disease: a cross-sectional study.

Frontiers in immunology
2026

Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells.

The American journal of pathology
2026

A superoxide anion-responsive persulfide prodrug for remedying dry eye disease.

Journal of controlled release : official journal of the Controlled Release Society
2025

Assessment of dry eye disease and retinal nerve fiber layer thickness in chronic smokers.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Longitudinal Immune Profiling of T Cell Exhaustion During IL-17A Blockade in a Patient With HLA-B27-negative Spondyloarthritis and Sjögren's Syndrome: A Case Report.

In vivo (Athens, Greece)
2025

Interstitial lung disease in Sjögren's disease: the portrait of a national cohort.

ARP rheumatology
2025

A non-invasive Schirmer strip-based analysis of tear cotinine and MMP-9 levels in chronic smokers.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2025

CD48, CD69, and TIGIT as diagnostic biomarkers for primary Sjögren's syndrome: an integrated machine learning and multi-disease discrimination validation study.

Frontiers in immunology
2025

Symptomatic vitamin A deficiency in a paediatric patient with short bowel syndrome.

BMJ case reports
2025

Temperature, Humidity and Regional Prevalence of Dry Eye Disease in Argentina.

Medicina (Kaunas, Lithuania)
2025

Diagnostic Value of Conjunctival Impression Cytology and Nelson Grading in Evaluating Dry Eye Disease in Ankylosing Spondylitis.

Medicina (Kaunas, Lithuania)
2025

Sex Differences in Autoimmune Multimorbidity Across Eleven Disorders: A Real-World Primary Care Study in Germany.

Medicina (Kaunas, Lithuania)
2026

Tear-Film Stability After Upper Blepharoplasty with Fractional CO2 Laser: A Retrospective 5-Month Series.

Photobiomodulation, photomedicine, and laser surgery
2025

Prevalence of Small A-Delta Fiber Neuropathy in Sjögren's Disease: Findings from a Cohort Study.

International journal of molecular sciences
2025

Special Issue "Molecular Advances in Dry Eye Syndrome".

International journal of molecular sciences
2025

From Autoimmune Sialadenitis to Central Pain: Hypothesizing Shared Pathogenesis for Fibromyalgia and Primary Sjogren's Disease and Identifying Essential Screening Strategies.

International journal of molecular sciences
2026

Ocular Matrix Metalloproteinases in Spaceflight.

Aerospace medicine and human performance
2025

Application of Fully Convolutional Neural Networks in the Assessment of Cerebral White Matter Involvement in Primary Sjögren's Syndrome.

Neuroinformatics
2026

Associations between ocular surface parameters, contrast sensitivity, and higher-order aberrations in computer vision syndrome.

Indian journal of ophthalmology
2026

Lacrimal gland Ga-68 PSMA-11 PET/CT radiomic profile: a potential novel imaging biomarker in dry eye disease.

Contact lens &amp; anterior eye : the journal of the British Contact Lens Association
2026

Usefulness of salivary gland ultrasonography in Sjögren's syndrome: The Tunisian Experience.

Clinical rheumatology
2025

The Distinct Monocyte Subsets and Intercellular Communication in Primary Sjögren's Syndrome Revealed by Single-Cell RNA Sequencing.

Journal of clinical immunology
2026

Ocular adverse effects of bisphosphonates and association with osteonecrosis from a real-world database.

Eye (London, England)
2025

Effects of artificial tears on ocular surface symptoms and visual task performance in digital device users.

Scientific reports
2026

Targeting the Gas6-TAM-SOCS1/3 axis: CP-25 attenuates macrophage dysfunction in primary Sjögren's syndrome.

Experimental cell research
2025

Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren's syndrome and identifies PS(36:1) as a potential therapeutic target.

Journal of translational medicine
2026

Effect of increasing chain length on inhibition of evaporation by perfluoro compounds in an in vitro gravimetric assay.

Experimental eye research
2026

Prevalence, incidence and mortality of interstitial lung disease in patients with Sjogren disease: data from the prospective observational "EMERGE" study.

Seminars in arthritis and rheumatism
2025

Exploring the potential of short-term oral folic acid on the ocular tear film: An intervention study.

Science progress
2025

Assessment of Oral Hygiene Behavioral and Demographic Risk Factors for Extrahepatic Manifestations of Hepatitis C.

Medical sciences (Basel, Switzerland)
2025

Multicentre Pixel-Level Tear Meniscus Segmentation Dataset with Multimodal Imaging for Dry Eye Diagnosis.

Scientific data
2026

Mapping the B-cell axis in Sjögren's disease: repertoire, microenvironment, and potential routes to precision treatment.

Current opinion in immunology

Associações

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

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Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation.
    Investigative ophthalmology &amp; visual science· 2026· PMID 41873899mais citado
  2. Prevalence and influencing factors of dry eye syndrome among pilots: A survey study.
    PloS one· 2026· PMID 41843563mais citado
  3. Conjunctival Impression Cytology and Dry Eye Parameters in Migraine Patients.
    Neurology India· 2026· PMID 41817066mais citado
  4. Therapeutic efficacy and safety of a multi-wavelength LED irradiation device in a rat model of meibomian gland dysfunction.
    Lasers in medical science· 2026· PMID 41811534mais citado
  5. A Droplet Evaporimeter for Evaluating Eye Care Formulations.
    Translational vision science &amp; technology· 2026· PMID 41800849mais citado
  6. Mast cell mediators in hereditary angioedema.
    Orphanet J Rare Dis· 2026· PMID 41832580recente
  7. Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
    Int J Mol Sci· 2026· PMID 41828453recente
  8. Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
    Orphanet J Rare Dis· 2026· PMID 41827036recente
  9. The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
    Orphanet J Rare Dis· 2026· PMID 41821052recente
  10. Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
    Orphanet J Rare Dis· 2026· PMID 41821046recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:519274(Orphanet)
  2. MONDO:0850007(MONDO)
  3. GARD:22083(GARD (NIH))
  4. Busca completa no PubMed(PubMed)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença sindrômica do sistema lacrimal
Compêndio · Raras BR

Doença sindrômica do sistema lacrimal

ORPHA:519274 · MONDO:0850007
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