Forma rara de lúpus cutâneo com lesões hiperqueratósicas, verrucosas e espessas, frequentemente em áreas expostas ao sol. Pode mimetizar outras condições dermatológicas, exigindo biópsia para diagnóstico.
Introdução
O que você precisa saber de cara
Visão geral
O Lúpus eritematoso hipertrófico ou verrucoso é uma forma rara de lúpus eritematoso cutâneo crônico. Ele se caracteriza por lesões na pele que são espessas, elevadas e com superfície verrucosa (semelhante a uma verruga). Esta condição afeta principalmente a pele e, diferentemente de outras formas de lúpus, geralmente não envolve órgãos internos de forma significativa.[1]
Sinais e sintomas
Os principais sinais são lesões cutâneas espessas, elevadas e com superfície áspera ou verrucosa. Essas lesões podem aparecer em áreas expostas ao sol, como rosto, couro cabeludo, braços e mãos. As lesões podem ser únicas ou múltiplas e, em alguns casos, podem coçar ou causar desconforto. A cicatrização pode deixar manchas ou cicatrizes.[1]
Causas genéticas
Até o momento, não há genes específicos identificados como causa direta do Lúpus eritematoso hipertrófico ou verrucoso. A condição não é considerada uma doença genética clássica, mas sim uma manifestação cutânea do lúpus eritematoso, que pode ter componentes genéticos e ambientais envolvidos em seu desenvolvimento.[1][2]
Diagnóstico
O diagnóstico é baseado principalmente no exame clínico das lesões de pele e na história do paciente. Uma biópsia da lesão pode ser realizada para confirmar o diagnóstico, mostrando características típicas de lúpus cutâneo crônico. Exames de sangue para anticorpos (como FAN) podem ser feitos para avaliar se há envolvimento sistêmico, mas não são específicos para esta forma. Testes genéticos não são indicados para o diagnóstico desta condição.[1][2]
Tratamento e manejo
O tratamento visa controlar as lesões de pele e prevenir novas lesões. Medidas gerais incluem proteção solar rigorosa (uso de filtro solar, roupas protetoras e evitar exposição ao sol). Medicamentos tópicos (cremes ou pomadas) com corticosteroides podem ser usados para reduzir a inflamação local. Em casos mais extensos ou resistentes, medicamentos orais como corticosteroides (ex.: prednisolona, dexametasona) podem ser considerados, sempre sob prescrição e acompanhamento médico. O tratamento deve ser individualizado e monitorado por um dermatologista ou reumatologista.[1]
Tratamentos citados na literatura
Não há dados disponíveis nos fatos fornecidos sobre tratamentos especificamente citados na literatura científica para esta condição. As informações sobre medicamentos mencionadas na seção anterior são baseadas em diretrizes gerais de manejo do lúpus cutâneo.[1]
Prognóstico e qualidade de vida
O prognóstico para o Lúpus eritematoso hipertrófico ou verrucoso é geralmente bom, pois a doença costuma ficar restrita à pele. Com tratamento adequado e proteção solar, as lesões podem melhorar ou cicatrizar. No entanto, podem ocorrer recidivas (novas lesões) e cicatrizes permanentes. A qualidade de vida pode ser afetada principalmente pelo aspecto estético das lesões e pela necessidade de cuidados contínuos com a pele. O acompanhamento médico regular é importante para monitorar a evolução e ajustar o tratamento.[1]
Conteúdo informativo gerado e mantido automaticamente a partir de fontes oficiais (Orphanet, HPO, OMIM, SUS). Não substitui avaliação médica.
O **lúpus eritematoso hipertrófico ou verrucoso** é uma condição rara catalogada sob o código internacional ORPHA:90282 e CID-10 L93.2. Os sintomas detalhados e as causas genéticas precisas ainda não se encontram descritos nos catálogos médicos de referência. No Brasil, o Ministério da Saúde disponibiliza o medicamento **Azatioprina** por meio do CEAF no SUS. O protocolo oficial existente aborda o Lúpus Eritematoso Sistêmico de maneira ampla, sem detalhar de forma isolada esta apresentação específica.
Forma rara de lúpus cutâneo com lesões hiperqueratósicas, verrucosas e espessas, frequentemente em áreas expostas ao sol. Pode mimetizar outras condições dermatológicas, exigindo biópsia para diagnóstico.
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Entender a doença
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Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Lúpus eritematoso hipertrófico ou verrucoso
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
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Combinatorial chemistry & high throughput screeningUnderstanding Pathophysiological Complexity of Feline Hypertrophic Cardiomyopathy Using SWATH-MS Plasma Proteomics.
Animals : an open access journal from MDPIMorphological and Molecular Characteristics of Choroid Plexus Epithelium in Aged Brains.
International journal of molecular sciencesNppa and Nppb Deficiency Drives Ventricular Hypertrophy and Subendocardial Gene Deregulation in the Mouse Heart.
International journal of molecular sciencesPCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
International journal of molecular sciencesMolecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.
International journal of molecular sciencesAn Open-Source Analysis of Cardiomyopathy Using Machine Learning and Electrocardiograms.
Diagnostics (Basel, Switzerland)IgG4-Related Disease Manifested as Hypertrophic Pachymeningitis: A Case Report and Literature Review.
Diagnostics (Basel, Switzerland)Diagnostic Performance of Relative Apical Sparing Across Cardiac Diseases: A Multimodality Systematic Review and Meta-Analysis.
Journal of clinical medicinePeripheral Hypertrophic Subepithelial Corneal Degeneration.
Journal of clinical medicineIdentification of a putative progenitor-like chondrocyte subpopulation in osteoarthritic human cartilage.
Stem cell research & therapySudden Death of a 17-Month-Old Chimpanzee (Pan troglodytes) due to a Congenital Undiagnosed Ventricular Septal Defect.
Journal of medical primatologyThe CD163:CD68 Ratio Reflects Splenic Macrophage Remodelling in Murine Chronic Schistosomiasis.
Parasite immunologyPredictors of Obstructive Coronary Artery Disease in Positive Electrocardiogram, Negative Echocardiogram Stress Tests: A Single-Centre Retrospective Analysis.
Heart, lung & circulationLeft Ventricular Mass Index as an independent predictor of major adverse cardiovascular and cerebrovascular events in patients with SLE.
Lupus science & medicineAnaesthethic management on a pediatric patient with Sengers syndrome. Case report.
Revista espanola de anestesiologia y reanimacionSeeing beneath the surface: Are current risk scores enough in hypertrophic cardiomyopathy?
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of CardiologyEffects of Ankylosing Spondylitis on Total Knee Arthroplasty Outcomes and Post-operative Manipulation Under Anesthesia Rates.
The Journal of arthroplastySingle-photon emission computed tomography functional liver imaging to facilitate reirradiation for liver malignancies: A phase I trial.
JHEP reports : innovation in hepatology"Congenital Muscular Pseudohypertrophy of the Upper Limb: Morphology, Anatomy and Surgical Guidelines of An Unique Entity".
Plastic and reconstructive surgeryDysphagia rehabilitation methods using kinesiology taping: A systematic review.
MedicineComprehensive Assessment of Left Ventricular Mass, Its Derived Indices, and Relative Wall Thickness in Ischemic Heart Disease.
CardiologyDevelopment and in vivo evaluation of a self-polymerizable tranilast-loaded silicone gel for scar modulation.
Journal of biomaterials applicationsE3 Ubiquitin Ligase UBR5 Aggravates Cardiac Hypertrophy Via Inhibiting Nrf2/HO-1 Pathway.
Cardiovascular drugs and therapyKLHL24-Associated Hypertrophic Cardiomyopathy: When Genotype Outpaces Phenotype.
JACC. Case reportsHypertrophic Lichen Planus.
Mayo Clinic proceedingsm6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review).
International journal of molecular medicineFasciola hepatica-Derived Proteins Shield the Heart From Type 2 Myocardial Infarction in Rats by Modulating Oxidative Stress and Inflammatory Imbalance: Insights Relevant to the Hygiene Hypothesis.
Oxidative medicine and cellular longevityEffect of Hypertension Duration on the Associations Between Intensive Blood Pressure Control and Cardiac, Vascular, and Kidney Organ Damage.
Journal of the American Heart AssociationGrowth performance and muscle histological characteristics of IPB-D3 chickens reared under intensive and free-range systems.
Veterinary worldThe exosomal miR-26b-3p derived from Crohn's disease-associated mesenteric adipose tissue induces M1 macrophage polarization and exacerbates ileocolonic anastomosis inflammation via the p38-MAPK signaling pathway.
Frontiers in immunologyMitochondrial quality control modulating chondrocyte behavior and fate in knee osteoarthritis: mechanistic insights and therapeutic prospects.
Frontiers in immunologyCharacteristics of Ear, Nose, and Throat Comorbidities among Children with Allergic Rhinitis.
International archives of otorhinolaryngologyDescription of the novel variant c.784delG;p. (Ala262Profs*68) at BSND gene and its association with Bartter Syndrome Type Iva.
Biomedical reportsHolistic Value Assessment of Tirbanibulin for Actinic Keratosis: European Multi-Criteria Decision Analysis.
Dermatology and therapyBalloon Dilation of the Eustachian Tube in Pediatric Patients.
Otolaryngologic clinics of North America[Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseasesEvaluation of ventricular dyssynchrony in fetuses of diabetic mothers measured by the tissue Doppler indices: a case-control study.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansDevelopment of a service line for laser resurfacing of hypertrophic burn scars: Focusing on peri-operative safety outcomes.
Burns : journal of the International Society for Burn InjuriesExploration of the rare 5/6/7-fused diterpenoids with anti-hypertrophy activity from Strophioblachia glandulosa via bioactivity-guided strategy.
PhytochemistryComprehensive evaluation of hypertrophic cardiomyopathy: European Journal of Heart Failure expert consensus document.
European journal of heart failurePINK1/Parkin-mediated mitophagy is involved in calcium-sensing receptor-induced cardiac damage and apoptosis in spontaneously hypertensive rats.
Journal of hypertensionAssociations of calciprotein particle maturation time with echocardiographic measures in the CRIC Study.
American journal of nephrologySeal and sea lion brains have evolved to support volitional control of vocal behavior and learning.
Science (New York, N.Y.)Characterization of participants with a disproportionate degree of hypertension-mediated organ damage: the Maastricht study.
Journal of hypertensionEarly administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.
PloS oneCo-existence of Ménétrier's Disease and Collagenous Colitis: A Diagnostic and Therapeutic Challenge.
Journal of general internal medicinePerformance and Safety of the Extravascular Implantable Cardioverter-Defibrillator in Patients With Hypertrophic Cardiomyopathy.
JACC. Clinical electrophysiologyDiagnosis and Treatment Guided by 3D Imaging and Modeling: A W-shaped Interventricular Septal Phenotype in Hypertrophic Obstructive Cardiomyopathy.
Radiology. Cardiothoracic imagingMassive Device-Related Thrombus After Left Atrial Appendage Closure in Kidney Transplant Recipient With Hypertrophic Cardiomyopathy.
JACC. Case reportsHypertrophic Pachymeningitis Presenting with Cerebral Venous Thrombosis.
Neurology IndiaAdhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Self-Strengthened PDT Coupling ROS Precise Regulation High-Penetration Microneedle for Adaptive Treatment of Pathological Scar.
ACS applied materials & interfacesAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Ainda não achamos doenças com sintomas parecidos o suficiente.
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
Existe um documento oficial para "Lúpus Eritematoso Sistêmico". Ele pode não cobrir esta forma específica da doença — confira no texto do protocolo antes de contar com ele.
É uma doença rara catalogada no sistema Orphanet pelo código ORPHA:90282. Ela recebe a classificação diagnóstica CID-10 L93.2 nos registros de saúde.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
3 fontes citadas no texto · 8 publicações do grafo RarasNet (PubMed) · 3 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (2026). Lúpus eritematoso hipertrófico ou verrucoso. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/lupus-eritematoso-hipertrofico-ou-verrucoso
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Lúpus eritematoso hipertrófico ou verrucoso
📋 Origem dos dados
Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Dado público estruturado
- fonte: Wikidata
- Reposicionamento
- fonte: Drug Repurposing Hub