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Síndrome de múltiplos pontos brancos evanescentes
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Introdução

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Síndrome das múltiplas manchas brancas evanescentes (MEWDS) é uma condição inflamatória incomum da retina que tipicamente afeta mulheres jovens, de outra forma saudáveis, entre a segunda e a quarta décadas de vida.

Publicações científicas
394 artigos
Último publicado: 2025 Sep
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Publicações mais relevantes

Timeline de publicações
231 papers (10 anos)
#1

NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.

American journal of ophthalmology2026 Mar 18

Non-infectious posterior and panuveitides (NIPUs) comprise a heterogeneous group of inflammatory disorders of the outer retina and choroid, historically referred to as "white dot syndromes." Recent consensus efforts by the Multimodal Imaging in Uveitis (MUV) Task Force have established standardized diagnostic criteria for the major NIPUs, including multiple evanescent white dot syndrome (MEWDS), multifocal choroiditis and panuveitis/punctate inner choroiditis (MFCPU/PIC), acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis, and birdshot chorioretinopathy (BSCR). Nevertheless, a substantial proportion of cases deviate from classical presentations and fall into diagnostic "grey zones", blurring boundaries between diseases entities and complicating both differential diagnosis and management. This review aims to describe the broad spectrum of atypical, variant, and secondary forms of NIPUs as well as masquerade syndromes. Atypical MEWDS includes bilateral presentations or complicated courses, while MFCPU/PIC with outer retinal atrophy emerges as a notable entity with unclear therapeutic implications. Inflammatory reactions resembling both MEWDS and MFCPU/PIC may also occur as secondary phenomena, triggered by other chorioretinal disorders, most notably inherited retinal diseases (IRDs). Placoid chorioretinopathies, including APMPPE, persistent placoid maculopathy, serpiginous choroiditis, and relentless placoid chorioretinitis, are often distinguished only a posteriori based on disease course, but likely represent a continuum of disorders unified by choroidal ischemia. Atypical presentations of BSCR may feature extensive outer retinal damage, mimicking IRDs. Equally important is the consideration of masquerade syndromes in all suspected cases of NIPUs, as they can present with similar features yet require entirely different treatments. Infectious masquerades include tuberculosis-associated serpiginous-like choroiditis, acute syphilitic posterior placoid chorioretinopathy, and West Nile virus chorioretinitis, whereas vitreoretinal lymphoma is the most frequent neoplastic masquerade. In conclusion, integrating clinical context with high-quality multimodal imaging remains essential to navigate the jungle of differential diagnosis in NIPUs, while future studies should aim to link imaging phenotypes with immune and molecular biomarkers to refine classification and guide targeted therapies.

#2

Multiple Evanescent White Dot Syndrome After mRNA COVID-19 Vaccination.

Cureus2026 Feb

A 46-year-old woman noticed blurred vision in her right eye two weeks after receiving the fourth dose of a COVID-19 vaccine and visited a local eye clinic. Then, the patient was referred to our hospital to investigate the cause of decreased vision in the right eye. At the initial visit to our hospital, the best-corrected visual acuity (BCVA) in the right eye was 0.7 in decimal units and 1.5 in the left eye, respectively. Intraocular pressure was 17 mmHg in both eyes. Abnormal findings were observed only in the right eye; the left eye was completely normal. Therefore, all abnormal findings described below are related to the right eye. Anterior segment examination revealed inflammatory cells in the anterior chamber. The lenses in both eyes were almost clear, and the right eye showed vitreous cells and vitreous opacity. Fundus examination revealed multiple small white exudative spots. Optical coherence tomography (OCT) demonstrated disruption of the ellipsoid zone (EZ) and hyper-reflective lesions beneath the retina. Fluorescein angiography (FA) showed hyperfluorescence consistent with staining at the sites of exudative lesions, while indocyanine green angiography (ICGA) revealed corresponding hypofluorescent spots due to blocked fluorescence. Full-field electroretinography (ERG) showed reduced amplitudes of both a- and b-waves. Goldman perimetry identified a central scotoma in the right eye. Based on these findings, the patient was diagnosed with multiple evanescent white dot syndrome (MEWDS) in the right eye. Topical betamethasone sodium phosphate and fradiomycin sulfate were initiated six times a day for the right eye at the first visit. The day after the initial visit, the BCVA in the right eye rapidly declined to 0.01 in decimal units, prompting the initiation of oral prednisolone at 30 mg/day. Eight days later, a sub-Tenon's capsule injection of triamcinolone acetonide (20 mg/0.5 ml) was administered. The symptoms gradually improved thereafter, and the hyper-reflective subretinal lesions observed on OCT disappeared. Oral steroid therapy was tapered, and the visual acuity (VA) improved to 1.0 in decimal units four months later. A case of MEWDS occurring after COVID-19 vaccination showed favorable recovery with oral steroid therapy and sub-Tenon's injection.

#3

Choroidal neovascularization secondary to punctate inner choroidopathy after resolution of multiple evanescent white dot syndrome: A case report.

Medicine2026 Mar 06

White dot syndromes include multiple evanescent white dot syndrome (MEWDS) and punctate inner choroidopathy (PIC), which are rarely reported to coexist or occur sequentially in a single eye. The co-occurrence increases diagnostic complexity, and there are no previous reports of choroidal neovascularization (CNV) secondary to PIC following the resolution of MEWDS. This case report aims to supplement clinical evidence for the pathogenesis and treatment of such sequential ocular diseases. A 42-year-old healthy female presented with blurred vision in her right eye for 3 days initially; 2 months later, her right eye vision worsened further, and 2.5 months after that, she developed blurred vision again with decreased visual acuity. At the first visit, the patient was diagnosed with MEWDS in her right eye based on fundus examination, fundus autofluorescence, fundus fluorescein angiography, visual field test, and optical coherence tomography (OCT) findings. Two months later, she was diagnosed with PIC in the same eye due to new peripapillary yellow-white lesions and corresponding OCT changes. Another 2.5 months later, she was diagnosed with CNV secondary to PIC based on subretinal hemorrhage, abnormal vascular flow on OCT angiography, and fundus fluorescein angiography confirmation. No treatment was given at the initial diagnosis of MEWDS. After the diagnosis of PIC, the patient received oral prednisone (1 mg/kg per day for 5 days, followed by gradual reduction over 6-8 weeks). For CNV secondary to PIC, intravitreal anti-vascular endothelial growth factor (VEGF) therapy (Ranibizumab, 0.5 mg/0.1 mL, once a month, twice in total) was administered. After 2 intravitreal anti-VEGF injections, the best-corrected visual acuity of the patient's right eye improved to 20/20, fundic hemorrhage resolved, and OCT demonstrated complete resolution of CNV. During 2 years of follow-up, no recurrence of CNV or PIC was observed, and best-corrected visual acuity remained stable at 20/20. MEWDS and PIC may share common etiological and pathogenetic mechanisms. PIC may develop sequentially after MEWDS in the same eye, and CNV may be a complication of PIC. A combination of oral corticosteroid therapy for PIC and timely intravitreal anti-VEGF injections for secondary CNV can achieve favorable long-term clinical outcomes. Regular follow-up is necessary for patients with MEWDS to monitor for potential progression to PIC and CNV.

#4

Relentless placoid chorioretinitis associated with Crohn's disease and secondary MEWDS: a case report.

American journal of ophthalmology case reports2026 Jun

To describe a rare case of relentless placoid chorioretinitis (RPC) associated with Crohn's disease, complicated by secondary multiple evanescent white dot syndrome (MEWDS). A 21-year-old man presented with acute, painless vision loss in the right eye. Multimodal retinal imaging showed numerous active and atrophic placoid lesions involving both the posterior pole and the retinal periphery, consistent with RPC. Systemic evaluation revealed Crohn's disease. Despite intravenous and oral corticosteroids, new extramacular lesions developed and fundus autofluorescence showed stippling compatible with secondary MEWDS. Introduction of anti-tumor necrosis factor (anti-TNF) therapy for Crohn's disease stabilized ocular inflammation. Visual prognosis remained poor in the affected eye and preserved in the fellow eye. This case highlights an association between RPC and Crohn's disease and supports an autoimmune mechanism. Early systemic evaluation and timely initiation of corticosteroid-sparing immunomodulatory therapy may help prevent recurrences and vision-threatening complications.

#5

A case of MEWDS like retinopathy associated with peripheral exudative haemorrhagic chorioretinopathy: Un caso de síndrome de múltiples puntos blancos evanescentes (SMPBE) secundario a coriorretinopatía hemorrágica exudativa periférica.

Archivos de la Sociedad Espanola de Oftalmologia2026 Feb 21

We describe a case of the recently described MEWDS like retinopathy in a patient with active PEHCR and history of bilateral non-arteritic ischaemic optic neuropathy (NAION). This patient was an 83-year-old man with a known history of PEHCR not requiring treatment and sequential NAION. He presented to the emergency eye services complaining of left eye (LE) reduced vision. Cystoid macular oedema (EMC) was noted. There were multiple hyper-autofluorescent dots within the macula which corresponded to subretinal hyper-reflective deposits on optical coherence tomography (OCT). The patient was observed with partial resolution of deposits and complete resolution of EMC noted 4 months following his initial presentation.

Publicações recentes

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📚 EuropePMC281 artigos no totalmostrando 196

2026

NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.

American journal of ophthalmology
2026

Multiple Evanescent White Dot Syndrome After mRNA COVID-19 Vaccination.

Cureus
2026

Choroidal neovascularization secondary to punctate inner choroidopathy after resolution of multiple evanescent white dot syndrome: A case report.

Medicine
2026

Relentless placoid chorioretinitis associated with Crohn's disease and secondary MEWDS: a case report.

American journal of ophthalmology case reports
2026

A case of MEWDS like retinopathy associated with peripheral exudative haemorrhagic chorioretinopathy: Un caso de síndrome de múltiples puntos blancos evanescentes (SMPBE) secundario a coriorretinopatía hemorrágica exudativa periférica.

Archivos de la Sociedad Espanola de Oftalmologia
2026

Secondary Multiple Evanescent White Dot Syndrome Associated with Active Central Serous Chorioretinopathy.

Retinal cases & brief reports
2026

Sex-Related Effects on the Clinical Presentation of Uveitis.

American journal of ophthalmology
2026

En Face Optical Coherence Tomography and OCT Angiography in the Pathoanatomy of Inflammatory Macular Disease.

American journal of ophthalmology
2025

Opposing pathophysiological concepts in multiple evanescent white dot syndrome: The great MEWDS schism.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
2025

Bilateral multiple evanescent white dot syndrome in an early adolescent patient: an atypical presentation.

BMJ case reports
2026

Multiple evanescent white dot syndrome: Typical, atypical, and secondary variants.

Progress in retinal and eye research
2025

Bilateral multiple evanescent white dot syndrome documented and followed by swept-source OCT angiography: a case report.

Journal of ophthalmic inflammation and infection
2025

Multiple evanescent white dot syndrome and presentations similar to multiple evanescent white dot syndrome in other disorders: a narrative review.

International journal of ophthalmology
2025

Noninfectious Uveitis Syndromes.

Advances in experimental medicine and biology
2025

The Characteristics of Primary Multiple Evanescent White Dot Syndrome: Comparison of Adolescent, Young and Middle-Aged, Elderly.

Ocular immunology and inflammation
2025

Multiple evanescent white dot syndrome associated with focal scleral nodule: a case report and literature review.

BMC ophthalmology
2025

Clinical characteristics of multiple evanescent white dot syndrome with poor visual prognosis in Japanese patients.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2025

Evidence and Consensus Based Imaging Guidelines in Multiple Evanescent White Dot Syndrome Multimodal imaging in Uveitis (MUV) Taskforce Report 6.

American journal of ophthalmology
2025

Same-side recurrence of unilateral multiple evanescent white dot syndrome following the thermal laser photocoagulation for inflammatory macular neovascularization.

GMS ophthalmology cases
2025

Multiple Evanescent White Dot Syndrome as Epiphenomenon of Infectious Chorioretinopathies.

Ocular immunology and inflammation
2025

Acute Angioid Streak Retinopathy is a Two-Phase Inflammatory Process Starting with Outer Retinal Inflammation, Followed by Secondary MEWDS.

Ocular immunology and inflammation
2025

"Bull's-Eye" on Structural En face Optical Coherence Tomography in Primary Multiple Evanescent White Dot Syndrome.

Retina (Philadelphia, Pa.)
2025

Optic disc pit: A trigger for secondary multiple evanescent white dot syndrome.

Retinal cases & brief reports
2025

Comparison of Fundus Autofluorescence and Indocyanine Green Angiography in Multiple Evanescent White Dot Syndrome.

Ophthalmology science
2025

Atypical Mid-Late Phase ICGA Hyperfluorescence in a Secondary MEWDS Case: A Distinct Disease or a Shift in Our Understanding of MEWDS?

Ocular immunology and inflammation
2025

The observation of the foveal granular reflexes with multiple evanescent white dot syndrome.

Retina (Philadelphia, Pa.)
2025

Case report: Two cases of multiple evanescent white dot syndrome with transient night blindness.

Frontiers in ophthalmology
2025

Multiple evanescent white dot syndrome masquerading as atypical optic neuritis: a case report.

Journal of medical case reports
2025

Stage 1 Extensive Macular Atrophy with Pseudodrusen-Like Appearance Complicated by Multiple Evanescent White Dot Syndrome-Like Reaction.

Ocular immunology and inflammation
2024

An update of multimodal imaging in white dot syndrome.

Oman journal of ophthalmology
2024

Choroidal vasculitis as a biomarker of inflammation of the choroid. Indocyanine Green Angiography (ICGA) spearheading for diagnosis and follow-up, an imaging tutorial.

Journal of ophthalmic inflammation and infection
2024

Multimodal imaging findings of multiple evanescent white dot syndrome in COVID-19 patients.

IDCases
2025

Multiple Evanescent White Dot Syndrome (MEWDS) Secondary to Acute Retinal Pigment Epitheliitis: Possible Atypical Presentation of MEWDS?

Ocular immunology and inflammation
2025

SECONDARY MULTIPLE EVANESCENT WHITE DOT SYNDROME IN A PATIENT WITH NORTH CAROLINA MACULAR DYSTROPHY.

Retinal cases & brief reports
2025

SECONDARY MULTIPLE EVANESCENT WHITE DOT SYNDROME AFTER BLUNT TRAUMA.

Retinal cases & brief reports
2025

PUNCTATE INNER CHOROIDOPATHY AFTER PARS PLANA VITRECTOMY FOR HIGH MYOPIC FULL-THICKNESS MACULAR HOLE.

Retinal cases & brief reports
2024

Application of Ophthalmic Electrophysiology in Inflammatory Disorders of Retina and Optic Nerve.

Journal of clinical medicine
2024

Multicenter and multimodal imaging study reveals rare fundus lesions in patients after SARS-CoV-2 infection.

Scientific reports
2024

EOG and the En-Face Inner Segment/Outer Segment-Ellipsoid Complex Image in Multiple Evanescent White Dot Syndrome.

International medical case reports journal
2024

Multiple evanescent white dot syndrome associated with COVID-19 infection: a case report.

Journal of medical case reports
2025

Long-Term Clinical Course and Treatment Outcomes in Occult and Overt Acute Zonal Outer Retinopathy.

Ocular immunology and inflammation
2024

Increased incidence and diverse manifestations of multiple evanescent white dot syndrome during the COVID-19 pandemic.

Scientific reports
2024

Comprehensive insights into COVID-19 vaccine-associated multiple evanescent white dot syndrome (MEWDS): A systematic analysis of reported cases.

Human vaccines & immunotherapeutics
2025

The Characteristics of White Dot Syndromes Following SARS-COV-2 Infection: A Systematic Review.

European journal of ophthalmology
2024

Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events: a narrative review.

International journal of ophthalmology
2024

Comparison of clinical findings and subjective symptoms in a case of multiple evanescent white dot syndrome (MEWDS): A case report from a patient's perspective.

Journal of general and family medicine
2024

Atypical multiple evanescent white dot syndrome presenting with peripheral retinal lesions.

BMJ case reports
2024

The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review.

International ophthalmology
2024

Photoreceptor Integrity in MEWDS: Longitudinal Structure-Function Correlations.

Investigative ophthalmology & visual science
2024

A case of secondary multiple evanescent white dot syndrome in a patient with preexisting wet age-related macular degeneration.

American journal of ophthalmology case reports
2024

White Dot Syndromes: Report of Three Cases.

Case reports in ophthalmology
2024

Multimodal Imaging in Diagnosing Multiple Evanescent White Dot Syndrome following Human Papillomavirus Vaccine Immunization.

Case reports in ophthalmological medicine
2024

A COVID-19 perspective of multiple evanescent white dot syndrome (MEWDS).

Indian journal of ophthalmology
2024

The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study.

BMC ophthalmology
2024

Differential diagnosis of myopic choroidal neovascularization (mCNV): insights from multimodal imaging and treatment implications.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2023

Ocular Inflammation Post-Vaccination.

Vaccines
2023

Multiple evanescent white dot syndrome relapse following BNT162b2 mRNA COVID-19 vaccination.

International journal of ophthalmology
2023

Presumed Müller Cell Activation in Multiple Evanescent White Dot Syndrome.

Investigative ophthalmology & visual science
2024

Choroidal neovascularization and MEWDS like reaction in a child: A rare case.

European journal of ophthalmology
2024

In response to: Ong AY, Birtel J, Agorogiannis E, Sharma SM, Charbel Issa P. Topographic patterns of retinal lesions in multiple evanescent white dot syndrome.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2024

Centrifugal progression of retinal lesions in the early evolution of multiple evanescent white dot syndrome.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2024

Acute Idiopathic Blind Spot Enlargement Syndrome (AIBSES) in the Era of OCT - a Review.

Klinische Monatsblatter fur Augenheilkunde
2023

Lightning can strike twice: recurrent multiple evanescent white dot syndrome (MEWDS) following both COVID-19 vaccination and subsequent COVID-19 infection.

Journal of ophthalmic inflammation and infection
2023

Unilateral Multiple Evanescent White Dot Syndrome-Like Reaction Following the CyberKnife Stereotactic Radiotherapy for Choroidal Malignant Melanoma.

Turkish journal of ophthalmology
2023

Latest advances in white spot syndromes: New findings and interpretations.

Progress in retinal and eye research
2023

Peripapillary retinal lesions: Is it multiple evanescent white dot syndrome?

Indian journal of ophthalmology
2023

Blue-Light Fundus Autofluorescence (BAF), an Essential Modality for the Evaluation of Inflammatory Diseases of the Photoreceptors: An Imaging Narrative.

Diagnostics (Basel, Switzerland)
2023

Alterations in the optic nerve and retina in patients with COVID-19. A theoretical review.

Archivos de la Sociedad Espanola de Oftalmologia
2023

OPTICAL COHERENCE TOMOGRAPHY IMAGING OF RETINAL MACROPHAGE-LIKE CELLS IN PATIENTS WITH MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retinal cases & brief reports
2023

Rare Case of Bilateral and Asymmetrical Multiple Evanescent White Dot Syndrome.

Cureus
2024

Ultrawide-field En face OCT of Multiple Evanescent White Dot Syndrome.

Ophthalmology
2023

Multiple Evanescent White Dot Syndrome Following Adenovirus Vector-Based COVID-19 Vaccine (Covishield).

Ocular immunology and inflammation
2023

Topographic patterns of retinal lesions in multiple evanescent white dot syndrome.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2023

Blind spot enlargement: A differential diagnosis challenge.

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
2023

PRIMARY MULTIPLE EVANESCENT WHITE DOT SYNDROME AND MULTIPLE EVANESCENT WHITE DOT SYNDROME SECONDARY TO MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY: A Comparative Study.

Retina (Philadelphia, Pa.)
2022

White Dot Syndrome Report in a SARS-CoV-2 Patient.

Case reports in ophthalmology
2023

Optical Coherence Tomography Angiography (OCT-A) in Uveitis: A Literature Review and a Reassessment of Its Real Role.

Diagnostics (Basel, Switzerland)
2024

Active Ocular Toxoplasmosis Associated with Simultaneous Multiple Evanescent White Dot Syndrome.

Ocular immunology and inflammation
2023

Multiple evanescent white dot syndrome in highly myopic eye in which fundus autofluorescence was diagnostically useful: A case report.

Medicine
2024

RECURRENCE OF ACUTE RETINOPATHY IN PSEUDOXANTHOMA ELASTICUM.

Retinal cases & brief reports
2023

Multiple Evanescent White Dot Syndrome Associated with Coronavirus Infection: A Case Report.

Iranian journal of medical sciences
2022

Ocular inflammatory manifestations following COVID-19 vaccinations in Taiwan: A case series.

Taiwan journal of ophthalmology
2022

Contralateral Recurrences of Post-vaccination Multiple Evanescent White Dot Syndrome.

Cureus
2022

An Elderly Man with Atypical Multiple Evanescent White Dot Syndrome.

Case reports in ophthalmology
2023

A multicenter study of ocular inflammation after COVID-19 vaccination.

Japanese journal of ophthalmology
2022

COMPARISON OF PRIMARY AND SECONDARY FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retina (Philadelphia, Pa.)
2022

Recurrent Multiple Evanescent White Dot Syndrome (MEWDS) Following First Dose and Booster of the mRNA-1273 COVID-19 Vaccine: Case Report and Review of Literature.

Vaccines
2023

Multiple evanescent white dot syndrome following COVID-19 vaccines.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2022

Case report: Visual snow as the presenting symptom in multiple evanescent white dot syndrome. Two case reports and literature review.

Frontiers in neurology
2023

Multiple Evanescent White Dot Syndrome Following COVID-19 mRNA Vaccination.

Ocular immunology and inflammation
2022

Multiple Evanescent White Dot Syndrome Developing Three Days following Administration of mRNA-1273 Booster Vaccine: Case Report.

Case reports in ophthalmology
2022

Diagnosis, Mechanisms, and Differentiation of Inflammatory Diseases of the Outer Retina: Photoreceptoritis versus Choriocapillaritis; A Multimodal Imaging Perspective.

Diagnostics (Basel, Switzerland)
2024

MULTIPLE EVANESCENT WHITE DOT SYNDROME FROM A PATIENT'S PERSPECTIVE.

Retinal cases & brief reports
2022

Multiple Evanescent White Dot Syndrome with Submacular Fluid in Dome-shaped Macula Following COVID-19 Vaccination: A Case Report.

Korean journal of ophthalmology : KJO
2022

Multiple evanescent white dot syndrome (MEWDS) and inactivated COVID-19 vaccination.

Arquivos brasileiros de oftalmologia
2022

Multiple Evanescent White Dot Syndrome following BioNTech SARS-CoV2 mRNA vaccination.

Journal francais d'ophtalmologie
2022

Choroidal neovascularization in a patient after resolution of multiple evanescent white dot syndrome: A case report.

Clinical case reports
2022

The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis.

Ocular immunology and inflammation
2022

Mechanisms, Pathophysiology and Current Immunomodulatory/Immunosuppressive Therapy of Non-Infectious and/or Immune-Mediated Choroiditis.

Pharmaceuticals (Basel, Switzerland)
2023

Changing Trends in Uveitis in the United Kingdom: 5000 Consecutive Referrals to a Tertiary Referral Centre.

Ocular immunology and inflammation
2022

Multiple Evanescent White Dot Syndrome Following Medigen Vaccine Biologics Corporation COVID-19 Vaccination.

Ocular immunology and inflammation
2022

Multiple evanescent white dot syndrome following BNT162b2 mRNA COVID-19 vaccination.

American journal of ophthalmology case reports
2022

White dot syndrome in a patient with presumed ocular tuberculosis: a case report.

International journal of retina and vitreous
2022

Multiple evanescent white dot syndrome following SARS-CoV-2 infection - A case report.

Indian journal of ophthalmology
2022

Multiple evanescent white dot syndrome (MEWDS) following inactivated COVID-19 vaccination (Sinovac-CoronaVac).

Arquivos brasileiros de oftalmologia
2022

Multiple evanescent white dot syndrome-like reaction associated with ipilimumab and nivolumab immune checkpoint inhibitor therapy for metastasis of choroidal melanoma.

American journal of ophthalmology case reports
2023

Multiple Evanescent White Dot Syndrome and Choroidal Neovascularization following SARS-COV-2 Infection in a Patient on Dabrafenib and Trametinib.

Ocular immunology and inflammation
2022

Multiple Evanescent White Dot Syndrome following COVID-19 mRNA Vaccination in Two Patients.

Ocular immunology and inflammation
2022

Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report.

Medicine
2022

Choroidal imaging in uveitis: An update.

Survey of ophthalmology
2021

Multiple evanescent white dot syndrome (MEWDS): update on practical appraisal, diagnosis and clinicopathology; a review and an alternative comprehensive perspective.

Journal of ophthalmic inflammation and infection
2021

Clinicopathology of non-infectious choroiditis: evolution of its appraisal during the last 2-3 decades from "white dot syndromes" to precise classification.

Journal of ophthalmic inflammation and infection
2021

Did the COVID-19 Pandemic Increase the Incidence of Acute Macular Neuroretinopathy?

Journal of clinical medicine
2021

Multimodal imaging in multiple evanescent white dot syndrome and new insights in pathogenesis.

Journal francais d'ophtalmologie
2021

Presumed Recurrent MEWDS following Covid-19 Vaccination.

Ocular immunology and inflammation
2021

Persistent photopsia: multiple evanescent white dot syndrome in a sexagenarian.

BMJ case reports
2023

HIGH-RESOLUTION SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retinal cases & brief reports
2022

Multiple Evanescent White-Dot Syndrome in a 9-Year-Old Girl.

Journal of vitreoretinal diseases
2021

Ocular Adverse Events After COVID-19 Vaccination.

Ocular immunology and inflammation
2022

An uncommon cold of the retina.

Survey of ophthalmology
2022

ARE THERE TWO FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME?

Retina (Philadelphia, Pa.)
2022

Chromatic pupillometry in multiple evanescent white dot syndrome masquerading as atypical optic neuritis.

Acta ophthalmologica
2021

UVEITIS AFTER THE BNT162b2 mRNA VACCINATION AGAINST SARS-CoV-2 INFECTION: A Possible Association.

Retina (Philadelphia, Pa.)
2021

Multiple Evanescent White Dot Syndrome (MEWDS) Associated with Progression of Lacquer Cracks in High Myopia.

Klinische Monatsblatter fur Augenheilkunde
2021

Acute Zonal Occult Outer Retinopathy (AZOOR) Results from a Clinicopathological Mechanism Different from Choriocapillaritis Diseases: A Multimodal Imaging Analysis.

Diagnostics (Basel, Switzerland)
2021

MULTIPLE EVANESCENT WHITE DOT SYNDROME MASQUERADER.

Retinal cases & brief reports
2021

Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials.

Diagnostics (Basel, Switzerland)
2021

Temporally independent association of multiple evanescent white dot syndrome and optic neuritis.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2021

Multiple Evanescent White Dot Syndrome Presenting After Initiation of Empagliflozin, a Sodium-Glucose Cotransporter-2 Inhibitor.

Cureus
2021

Classification Criteria For Multiple Evanescent White Dot Syndrome.

American journal of ophthalmology
2021

[Multiple Evanescent White Dot Syndrome (MEWDS) with severe visual acuity loss].

Journal francais d'ophtalmologie
2022

Review of the Current Literature and Our Experience on the Value of OCT-angiography in White Dot Syndromes.

Ocular immunology and inflammation
2021

Multiple evanescent white dot syndrome: Bilateral disease may be silent and asymmetric.

American journal of ophthalmology case reports
2021

A Multiple Evanescent White Dot Syndrome-like Reaction to Concurrent Retinal Insults.

Ophthalmology. Retina
2021

Multiple Evanescent White Dot Syndrome: Findings from a Large Northern California Cohort.

Ophthalmology. Retina
2020

Early Progressive Circumpapillary Lesion as Atypical Presentation of Multiple Evanescent White Dot Syndrome: A Case Report.

Case reports in ophthalmology
2021

Atypical multimodal imaging findings in a patient with multiple evanescent white dot syndrome.

Journal francais d'ophtalmologie
2021

Multiple Evanescent White Dot Syndrome Presenting in a Patient With Punctate Inner Choroidopathy.

Journal of vitreoretinal diseases
2020

Multiple evanescent white dot syndrome and panuveitis: a case report.

Journal of ophthalmic inflammation and infection
2021

Corrigendum to 'Syphilitic posterior placoid chorioretinopathy presenting as atypcal multiple evanescent white dot syndrome'.

European journal of ophthalmology
2022

Multiple evanescent white dot syndrome: clinical course and factors influencing visual acuity recovery.

The British journal of ophthalmology
2020

Choroidal nonperfusion on optical coherence tomography angiography in a case of unilateral posterior segment ocular sarcoidosis misdiagnosed as MEWDS.

American journal of ophthalmology case reports
2020

Multiple evanescent white dot syndrome following influenza immunization - A multimodal imaging study.

American journal of ophthalmology case reports
2021

Acute syphilitic posterior placoid chorioretinopathy presenting as atypical multiple evanescent white dot syndrome.

European journal of ophthalmology
2022

Expanding the Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Overlapping Multifocal Choroiditis.

Ocular immunology and inflammation
2020

Unusual presentation of multiple evanescent white dot syndrome and importance of optical coherence tomography angiography to diagnose choroidal neovascularization under inflammed choriocapillaris.

Indian journal of ophthalmology
2020

Ultra-widefield confocal imaging of multiple evanescent white dot syndrome.

American journal of ophthalmology case reports
2020

Acute Idiopathic Blind Spot Enlargement and Acute Zonal Occult Outer Retinopathy: Potential Mimics of Neuro-Ophthalmic Disease.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2020

Outer Retinal Plume Signature in Multiple Evanescent White Dot Syndrome.

Ophthalmology. Retina
2020

Swept-Source Optical Coherence Tomography Angiography Shows Choriocapillaris Flow Reduction in Multiple Evanescent White Dot Syndrome.

Journal of current ophthalmology
2020

Multiple Evanescent White Dot Syndrome: A Case Report and Experience with Corticosteroid Therapy.

Iranian journal of allergy, asthma, and immunology
2020

Spectralis High Magnification Module imaging in a case of Multiple Evanescent White Dot Syndrome.

American journal of ophthalmology case reports
2020

Quantitative analysis of retinal and choriocapillary vascular density of multiple evanescent white dot syndrome by optical coherence tomography angiography.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2020

Oguchi disease caused by a homozygous novel SAG splicing alteration associated with the multiple evanescent white dot syndrome: A 15-month follow-up.

Documenta ophthalmologica. Advances in ophthalmology
2020

A CARE-compliant article: a case report of possible association between recurrence of multiple evanescent white dot syndrome and the Herpesviridae family.

Medicine
2021

INTRARETINAL HYPERREFLECTIVE LINES.

Retina (Philadelphia, Pa.)
2020

Retinal dysfunction of syphilitic outer retinopathy.

Documenta ophthalmologica. Advances in ophthalmology
2020

Changes in intraocular pressure and aqueous flare in eyes with multiple evanescent white dot syndrome.

Japanese journal of ophthalmology
2021

Longitudinal Retinal Layer Changes and Clinical Outcome in Patients with Multiple Evanescent White Dot Syndrome.

Ocular immunology and inflammation
2022

AUTOFLUORESCENT TIMELINE OF SPOTS AND DOTS IN MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retinal cases & brief reports
2020

Masqueraders of multiple evanescent white dot syndrome (MEWDS).

International ophthalmology
2019

[White dot syndromes : Principles, diagnostics, and treatment].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
2021

Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome.

Ocular immunology and inflammation
2019

Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS.

International journal of retina and vitreous
2019

Choroidal juxtapapillary neovascularization regression in multiple evanescent white dot syndrome by optical coherence tomography angiography: a case report.

Journal of medical case reports
2019

Multiple Evanescent White Dot Syndrome Presenting in Possibly Contracted Hand-Foot-and-Mouth Disease: A Rare Presentation.

Cureus
2020

Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation.

Ocular immunology and inflammation
2019

Potentially Novel Acute Retinopathy Similar to Multiple Evanescent White Dot Syndrome in Patients With Pseudoxanthoma Elasticum.

JAMA ophthalmology
2019

Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome.

Journal of ophthalmology
2018

Multiple evanescent white dot syndrome following rabies vaccination: a case report.

BMC ophthalmology
2018

Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.

Romanian journal of ophthalmology
2018

Resolution of Photoreceptor Layer Damage in Multiple Evanescent White Dot Syndrome.

Journal of ophthalmic & vision research
2018

Atypical white dot syndrome with choriocapillaris ischemia in a patient with latent tuberculosis.

Journal of ophthalmic inflammation and infection
2018

Swept-source OCT in patients with multiple evanescent white dot syndrome.

Journal of ophthalmic inflammation and infection
2018

A Case of Focal Choroidal Excavation Development Associated with Multiple Evanescent White Dot Syndrome.

Case reports in ophthalmology
2018

Assessing the Precision of ICD-10 Codes for Uveitis in 2 Electronic Health Record Systems.

JAMA ophthalmology
2018

Swept-Source OCT Angiography of Multiple Evanescent White Dot Syndrome With Inflammatory Retinal Pigment Epithelial Detachment.

Ophthalmic surgery, lasers & imaging retina
2019

Multiple Evanescent White Dot Syndrome Following Intradermal Influenza Vaccination.

Ocular immunology and inflammation
2019

CHARACTERIZATION AND CORRELATION OF "JAMPOL DOTS" ON ADAPTIVE OPTICS WITH FOVEAL GRANULARITY ON CONVENTIONAL FUNDUS IMAGING.

Retina (Philadelphia, Pa.)
2017

Multimodal imaging features of resolving multiple evanescent white dot syndrome.

Indian journal of ophthalmology
2020

AN ELDERLY PATIENT WITH ACUTE TRANSIENT OUTER RETINAL DISRUPTION RESEMBLING BILATERAL MULTIPLE EVANESCENT WHITE DOT SYNDROME.

Retinal cases & brief reports
2018

Optical coherence tomography angiography shows an intact choriocapillaris flow in multiple evanescent white dot syndrome.

International ophthalmology
2019

Multiple Evanescent White Dot Syndrome Following Acute Epstein-Barr Virus Infection.

Ocular immunology and inflammation
2019

Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal Granularity.

Ocular immunology and inflammation
2018

Choroidal neovascularisation triggered multiple evanescent white dot syndrome (MEWDS) in predisposed eyes.

The British journal of ophthalmology
2017

Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome.

International journal of ophthalmology
2017

Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography.

Ophthalmic surgery, lasers & imaging retina
2018

Bilateral multiple evanescent white dot syndrome.

International ophthalmology
2017

Clinical Features of Pregnancy-associated Retinal and Choroidal Diseases Causing Acute Visual Disturbance.

Korean journal of ophthalmology : KJO
2017

The Value of Diagnostic Work-Up in the Evaluation of White Dot Syndromes.

Ophthalmic surgery, lasers & imaging retina
2019

MULTIPLE EVANESCENT WHITE DOT SYNDROME WITH SUBRETINAL DEPOSITS.

Retinal cases & brief reports
2017

Multimodal Imaging in an Unusual Cluster of Multiple Evanescent White Dot Syndrome.

Journal of ophthalmology
2017

The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases.

Progress in retinal and eye research
2018

Regarding comments by Mathis T and Kodjikian L on "Choroidal Neovascularization Associated with Multiple Evanescent White Dot Syndrome Treated with Intravitreal Ranibizumab".

Ocular immunology and inflammation
2018

In response to: Parodi MB, Iacono P, Zucchiatti I, et al. Choroidal Neovascularization Associated with Multiple Evanescent White Dot Syndrome Treated with Intravitreal Ranibizumab.

Ocular immunology and inflammation
2018

Recurrent focal choroidal excavation following multiple evanescent white dot syndrome (MEWDS) associated with acute idiopathic blind spot enlargement.

International ophthalmology
Ver todos os 281 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.
    American journal of ophthalmology· 2026· PMID 41861897mais citado
  2. Multiple Evanescent White Dot Syndrome After mRNA COVID-19 Vaccination.
    Cureus· 2026· PMID 41822649mais citado
  3. Choroidal neovascularization secondary to punctate inner choroidopathy after resolution of multiple evanescent white dot syndrome: A case report.
    Medicine· 2026· PMID 41790663mais citado
  4. Relentless placoid chorioretinitis associated with Crohn's disease and secondary MEWDS: a case report.
    American journal of ophthalmology case reports· 2026· PMID 41778093mais citado
  5. A case of MEWDS like retinopathy associated with peripheral exudative haemorrhagic chorioretinopathy: Un caso de síndrome de múltiples puntos blancos evanescentes (SMPBE) secundario a coriorretinopatía hemorrágica exudativa periférica.
    Archivos de la Sociedad Espanola de Oftalmologia· 2026· PMID 41730419mais citado
  6. OPTIC DISK COLOBOMA MAY TRIGGER MULTIPLE EVANESCENT WHITE DOT SYNDROME: EXPANDING THE CLINICAL SPECTRUM.
    Retin Cases Brief Rep· 2025· PMID 41995409recente
  7. Multiple Evanescent White Dot Syndrome (MEWDS) Following COVID-19 Infection: A Presumed Recurrence.
    Cureus· 2026· PMID 41913858recente
  8. MEWDS-like Presentation Unmasking Sequential Bilateral Multifocal Choroiditis: Insights from Longitudinal Multimodal Imaging.
    Biomedicines· 2026· PMID 41898295recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:674953(Orphanet)
  2. MONDO:0971128(MONDO)
  3. Busca completa no PubMed(PubMed)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome de múltiplos pontos brancos evanescentes
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Síndrome de múltiplos pontos brancos evanescentes

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