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Síndrome pulmonar por hantavírus
ORPHA:319247CID-10 · B33.4+CID-11 · 1D62.1DOENÇA RARA

Uma infecção causada por hantavírus. Manifesta-se com sintomas semelhantes aos da gripe, mas progride rapidamente para problemas respiratórios que ameaçam a vida.

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Introdução

O que você precisa saber de cara

Mantido pelo Disease Twin100% com fonte · atualizado 24/09/2026Revisão médica pendente
Informacoes curadas por IA — podem conter imprecisoes

Visão geral

A Síndrome pulmonar por hantavírus (identificada pelo código MONDO:0017879 e CID-10 B33.4+) é uma infecção causada por hantavírus. O quadro clínico manifesta-se inicialmente com sintomas semelhantes aos da gripe, mas apresenta uma evolução que progride rapidamente para problemas respiratórios graves que ameaçam a vida.[1]

Tratamentos citados na literatura

A literatura biomédica indexada registra estudos associando certas substâncias e compostos ao contexto de investigação da Síndrome pulmonar por hantavírus. Estas menções são identificadas por mineração de textos científicos e representam dados de pesquisa, não constituindo recomendação médica ou indicação clínica formal: Ribavirin (9 publicações), Cobalt (7 publicações), Amphotericin B (5 publicações), Steroids (5 publicações), Lipids (4 publicações), tungsten carbide (4 publicações), Bevacizumab (4 publicações), Dexamethasone (4 publicações), Alcohols (3 publicações) e Indoleacetic Acids (3 publicações). Existem atualmente 2 ensaios clínicos ativos associados à doença.[2]

Fontes numeradas em Referências.

Conteúdo informativo gerado e mantido automaticamente a partir de fontes oficiais (Orphanet, HPO, OMIM, SUS). Não substitui avaliação médica.

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EM LINGUAGEM SIMPLES

A síndrome pulmonar por hantavírus é uma infecção grave causada pelo contato com vírus da família dos hantavírus. A doença se inicia com sintomas semelhantes aos de uma gripe, mas pode evoluir rapidamente para dificuldades respiratórias severas com risco de vida. Por se tratar de uma emergência de evolução acelerada, os pacientes necessitam de acolhimento e suporte intensivo imediato em hospitais do SUS. Não se trata de uma enfermidade genética herdada e ela não consta na lista oficial de protocolos clínicos (PCDT) de doenças raras do Ministério da Saúde.

Informacoes curadas por IA — podem conter imprecisoes
[1] Orphanet [17] Ministério da Saúde — lista oficial de…
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Informacoes curadas por IA — podem conter imprecisoes

Uma infecção causada por hantavírus. Manifesta-se com sintomas semelhantes aos da gripe, mas progride rapidamente para problemas respiratórios que ameaçam a vida.

Pesquisas ativas
2 ensaios
5 total registrados no ClinicalTrials.gov
Publicações científicas
801 artigos
Último publicado: 2026 Jan
Medicamentos
20 com registro
CLORIDRATO DE AMBROXOL, ESPECBAC, TOSSLAB

Tem tratamento?

✓ 20 medicamentos específicos desta doença (registro ANVISA, FDA ou SUS/CEAF)
Ver detalhes, fases e interações →
CLORIDRATO DE AMBROXOLESPECBACTOSSLABFLUIBRONFLUISOLVANAMBROLSEDAVANMUCOXOLAN
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SUS: Cobertura mínimaScore: 0%
CID-10: B33.4+
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico801PubMed
Últimos 10 anos200publicações
Pico201935 papers
Linha do tempo
2026Hoje · 2026🧪 2003Primeiro ensaio clínico📈 2019Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 21
1Fase 11
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 5 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome pulmonar por hantavírus

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Nenhum país com ensaio aberto no momento.

Pesquisa e ensaios clínicos

5 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
224 papers (10 anos)
#1

Purifying selection constrains the evolution of Juquitiba virus in wild Oligoryzomys nigripes communities.

PLoS pathogens2026 Jan

Juquitiba virus (JUQV) is endemic in Oligoryzomys nigripes across several South American countries and causes hantavirus pulmonary syndrome when transmitted to humans via infectious saliva or excreta. We developed a next-generation sequencing (NGS) pipeline to generate the first complete reference genome for assessing the genetic diversity of JUQV in Oligoryzomys populations inhabiting the Mbaracayú Biosphere Reserve within the Atlantic Forest of Paraguay. From 32 additional Oligoryzomys specimens, we obtained 17 S- and M-segment viral RNA (vRNA) genomes from lungs with 94-100% sequence coverage and 101 additional vRNAs with ≥80% genome coverage and ≥500x sequence depth from saliva, urine, lungs, heart, kidney, liver, and spleen. Phylogenetic and phylogeographic analyses showed that the Paraguayan JUQV is genetically distinct from the Brazilian JUQV lineage. Shannon entropy calculations of genetic diversity revealed that saliva and lung samples had higher entropy values than urine, kidney, spleen, and heart samples. The greater genetic diversity was driven in part by greater nucleotide, but not amino acid, diversity in persistently infected rodent samples compared to acutely infected ones. Genetic diversity varied across collection sites, although, given the continuous habitat matrix, there was no apparent reason for these differences. Fixed Effects Likelihood analysis of lung, saliva, and urine sequences suggested that purifying selection was the primary driver of evolution, with no evidence of positive selection. Only three of the 29 codons in the N protein and the glycoprotein (GP) were under purifying selection, and only Gn harbored nonsynonymous mutations. We tested two of the nonsynonymous mutations within the Gn for their effect on entry into Vero cells using VSV-pseudotyped JUQV GP; however, only V504I resulted in a significant reduction in entry compared to wild-type Gn. In summary, tissue source, field locale, and persistent infection were clear drivers of virus evolution.

#2

Detection of Anti-Orthohantavirus Antibodies in Febrile Patients in India.

Microbiology and immunology2026 Mar

Orthohantaviruses are a genus of zoonotic viruses from the family Hantaviridae, which is primarily known for their ability to cause severe human diseases. The virus is primarily known for causing two major human diseases, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. However, the frequency of this infection remains largely unknown. Hence, the aim of this study was to diagnose patients infected with Orthohantavirus in India. We tested serum samples from 216 febrile patients, presented at Lisie Hospital, Kochi, for positive anti-orthohantavirus IgM and IgG antibodies. All the participating patients were negative for dengue and scrub typhus IgM antibodies. In total, 16.20% (n = 35) of the febrile patients were positive for anti-orthohantavirus IgM and 11.57% (n = 25) for anti-orthohantavirus IgG antibodies. Anti-orthohantavirus IgM and IgG both were detected in 4.63% (n = 10) of the enrolled subjects. In total, 51.43% of the IgM-positive patients had a final diagnosis of either viral fever or acute febrile disease, with only two patients reported to have contact with rodents, and none of these patients had traveled outside of their place of residence. Orthohantavirus infections may be endemic in India, as their hosts are omnipresent. However, the lack of proper diagnostic tools and limited awareness of these emerging infections amongst doctors in India reduces the diagnosis of the disease. Therefore, there is a pressing need for educating healthcare providers about the circulation of orthohantaviruses in India. There is an urgent need for the development of serotype-specific, affordable, and accurate diagnostic tools for early diagnosis of orthohantavirus infections.

#3

Beliefs and socio-cultural perspectives on hantavirus in a rural community in Panama: An ethnonursing study.

PLOS global public health2025

Hantavirus pulmonary syndrome is a zoonotic disease that has been present in the Americas since 1993 and in Panama since the early 2000s. The disease is transmitted to humans through the inhalation of aerosols containing viruses from feces, urine, and saliva from asymptomatic, infected rodents. While various climatic, ecological, social and cultural factors have been associated with hantavirus transmission, research on beliefs and socio-cultural perspectives regarding its care and prevention remains limited. This study addresses this gap by exploring the beliefs, socio-cultural context and care practices related to hantavirus disease in an endemic community. Guided by the One Health approach and Leininger's Theory of Culture Care Diversity and Universality, an ethnonursing approach was used in a hantavirus-endemic community in Panama from September 3, 2021, to August 25, 2022. The study involved 30 participants, including 11 key participants (community members with personal or familial experience of hantavirus) and 19 general participants (community authorities and health professionals). Data were collected through in-depth interviews, participant observation and field notes. Leininger's four phases of ethnonursing analysis were followed using ATLAS.ti. Five themes were identified: (1) hantavirus develops within the context of the community, with its own expressions, meanings and lifestyles; (2) living in and of the land: what we are and what defines us; (3) hantavirus prevention and its challenges: what we do and what we propose; (4) God, the higher power that helps, protects, and gives strength and resilience in daily life and in the face of hantavirus disease; and (5) sharing within the family: joys, longings, celebrations and concerns about hantavirus. Based on the study findings, we propose a model of culture care decision and action modes for hantavirus prevention, emphasizing the importance of implementing relevant, sustainable, and culturally aligned prevention practices in the affected communities.

#4

Virological characterization of a new isolated strain of Andes virus involved in the recent person-to-person transmission outbreak reported in Argentina.

PLoS neglected tropical diseases2025 Jun

On November 2, 2018, a person-to-person transmission outbreak of Andes virus (Orthohantavirus andesense) began in the small town of Epuyén, Argentina. The strain demonstrated a high capacity for sustained transmission among the human population requiring the implementation of quarantine measures, rigorous contact tracing, isolation of close contacts, and active clinical monitoring to prevent further spread. In this study, we report the isolation of this strain, which we name the ARG-Epuyén strain, directly from a clinical sample after just three passages in cell culture. Complete sequencing revealed only a single amino acid change post-isolation, suggesting that this strain can be considered a non-adapted wild-type Andes virus, marking a critical step toward the development of medical countermeasures against this emerging pathogen. The pathogenicity and transmissibility potential of ARG-Epuyén were evaluated in hamsters, the only animal model for Hantavirus Pulmonary Syndrome. Additionally, this strain was compared with Andes/ARG, an ANDV strain previously isolated from the same geographical area in the Argentinian Patagonia, from a rodent specimen. Our findings revealed high infectiousness and efficient hamster-to-hamster transmission through direct contact experiments, although ARG-Epuyén appeared to be less pathogenic than Andes/ARG.

#5

A systematic review of the distribution and prevalence of viruses detected in the Peromyscus maniculatus species complex (Rodentia: Cricetidae).

PLoS pathogens2025 Jun

The North American Deermouse, Peromyscus maniculatus, is one of the most widespread and abundant mammals on the continent. It is of public health interest as a known host of several viruses that are transmissible to humans and can cause illness, including the acute respiratory disease Hantavirus pulmonary syndrome (HPS). However, recent taxonomic studies indicate that P. maniculatus is a complex of multiple species, raising questions about how to identify and interpret three decades of hantavirus monitoring data. We conducted a systematic review investigating the prevalence and spatial distribution of viral taxa detected in wild populations allocated to P. maniculatus. From the 49 relevant studies published from 2000 to 2022, we extracted and analyzed spatial occurrence data to calculate weighted populational prevalences for hantaviruses. We found that detection efforts have been concentrated in the Western United States and Mexico with a focus on the spread of Sin Nombre virus (Orthohantavirus sinnombreense), the primary causative agent of HPS. There are significant gaps in the existing literature both geographically and regarding the kinds of viruses being sampled. These results are significantly impacted by a recent taxonomic split of P. maniculatus into four species, and we were able to update 94% of hantavirus observations to reflect this change. Investigating the uncertain, and likely multiple, phylogenetic histories of these viral hosts should be a key emphasis of future modeling efforts.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC333 artigos no totalmostrando 194

2026

Purifying selection constrains the evolution of Juquitiba virus in wild Oligoryzomys nigripes communities.

PLoS pathogens
2026

Detection of Anti-Orthohantavirus Antibodies in Febrile Patients in India.

Microbiology and immunology
2025

[Hantavirus cardiopulmonary syndrome in the intensive care unit].

Medicina
2025

Hantavirus is Associated With Open Developed Areas and Arid Climates, Highlighting Increased Risk in the Western United States.

Transboundary and emerging diseases
2025

Beliefs and socio-cultural perspectives on hantavirus in a rural community in Panama: An ethnonursing study.

PLOS global public health
2025

Epidemiologic and Environmental Investigations of Reported Hantavirus Cases Inform Exposure Risk in California, 1993-2020.

The American journal of tropical medicine and hygiene
2025

Beyond ECMO Survival: Long-Term Symptom Burden and Quality-of-Life Impairment in Hantavirus Cardiopulmonary Syndrome Survivors.

Viruses
2025

Aerostability of Sin Nombre Virus Aerosol Related to Near-Field Transmission.

Pathogens (Basel, Switzerland)
2025

Pathogenicity and virulence of Rodent-Borne Orthohantaviruses.

Virulence
2025

Phloroglucinol Oligomers from Callistemon rigidus as Novel Anti-Hantavirus Replication Agents.

Viruses
2025

High genomic stability of Andes virus following successive passage in vivo in Syrian hamsters.

Journal of virology
2025

Rodent-borne zoonotic diseases in Southeast Asia: A narrative review.

Tropical biomedicine
2025

Virological characterization of a new isolated strain of Andes virus involved in the recent person-to-person transmission outbreak reported in Argentina.

PLoS neglected tropical diseases
2025

Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts.

Ecosphere (Washington, D.C)
2025

A systematic review of the distribution and prevalence of viruses detected in the Peromyscus maniculatus species complex (Rodentia: Cricetidae).

PLoS pathogens
2025

Evaluating Neutralizing Antibodies in Hantavirus-Infected Patients Using Authentic Virus and Recombinant Vesicular Stomatitis Virus Systems.

Viruses
2025

Novel Orthohantavirus Associated with Hantavirus Pulmonary Syndrome in Northern Argentina.

Viruses
2025

CO-OCCURRENCE OF HANTAVIRUS PULMONARY SYNDROME AND HEMORRHAGIC FEVER WITH RENAL SYNDROME.

Georgian medical news
2025

Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology.

Viruses
2025

IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS.

PLoS pathogens
2025

[Controversies on Hantavirus].

Medicina
2025

Seroconversion Model for a Better Understanding of Hantavirus Transmission in Rodents.

EcoHealth
2025

Report of a novel pathogenic orthohantavirus in Tucuman, Argentina.

Revista Argentina de microbiologia
2025

Achievement and Challenges in Orthohantavirus Vaccines.

Vaccines
2025

Sin Nombre Virus as Unlikely Reverse Zoonotic Threat.

Emerging infectious diseases
2025

Bayou Hantavirus Cardiopulmonary Syndrome, Louisiana, USA, 2022-2023.

Emerging infectious diseases
2025

Hantavirus pulmonary syndrome in a COVID-19 patient, Bolivia, 2022.

New microbes and new infections
2025

A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.

PLoS pathogens
2024

Serological Evidence of Hantavirus in Bats from the Brazilian Atlantic Forest: An Investigation of Seroreactivity and Cross-Reactivity of Neotropical Bat Samples Using Nucleoproteins of Rodent- and Bat-Borne Hantaviruses.

Viruses
2025

Hantavirus Pulmonary Syndrome in Northwestern Argentina: Seroprevalence in rodents of Jujuy province and first seropositive record for Euryoryzomys legatus.

Acta tropica
2024

Development of a seroepidemiological tool for bat-borne and shrew-borne hantaviruses and its application using samples from Zambia.

PLoS neglected tropical diseases
2024

Orthohantavirus diversity in Central-East Argentina: Insights from complete genomic sequencing on phylogenetics, Geographic patterns and transmission scenarios.

PLoS neglected tropical diseases
2024

Hantavirus Pulmonary Syndrome Outbreak Anticipation by a Rapid Synchronous Increase in Rodent Abundance in the Northwestern Argentina Endemic Region: Towards an Early Warning System for Disease Based on Climate and Rodent Surveillance Data.

Pathogens (Basel, Switzerland)
2024

Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source.

mBio
2024

25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism.

Free radical biology & medicine
2024

Hantavirus Cardiopulmonary syndrome: Another Reason to Avoid Mice.

Journal of investigative medicine high impact case reports
2024

Human Orthohantavirus disease prevalence and genotype distribution in the U.S., 2008-2020: a retrospective observational study.

Lancet regional health. Americas
2024

Hantavirus Expansion Trends in Natural Host Populations in Brazil.

Viruses
2024

Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons.

PLoS pathogens
2024

Critical care management of hantavirus cardiopulmonary syndrome. A narrative review.

Journal of critical care
2024

Evaluating climate-dependent distribution of orthohantaviruses with monitoring wild rodents: One Health Perspective†.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2024

The role of health mediation in investigation of Hantavirus cases among informal settlements inhabitants of Cayenne area, French Guiana, 2022-2023.

Frontiers in public health
2024

Orthohantaviruses in Misiones Province, Northeastern Argentina.

Emerging infectious diseases
2024

Development and standardization of an enzyme-linked inmunosorbent for the detection of orthohantavirus infection in Argentina based on its bacterial-expressed nucleocapside protein.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2024

Preventive Practices of Hantavirus in a Rural Community in Panama: An Explanatory Sequential Mixed Methods Study.

Journal of transcultural nursing : official journal of the Transcultural Nursing Society
2024

Hybrid capture-based next-generation sequencing of new and old world Orthohantavirus strains and wild-type Puumala isolates from humans and bank voles.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
2024

Hantavirus Pulmonary Syndrome in an Adolescent from North Dakota.

The Pediatric infectious disease journal
2024

Distribution and prevalence of Sin Nombre hantavirus in rodent species in eastern New Mexico.

PloS one
2023

Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus-A Case Report and Literature Review.

Microorganisms
2023

Orthohantavirus Infection in Two Rodent Species that Inhabit Wetlands in Argentina.

EcoHealth
2023

Seroprevalence of Hantavirus among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil.

Viruses
2023

Sin Nombre Virus and the Emergence of Other Hantaviruses: A Review of the Biology, Ecology, and Disease of a Zoonotic Pathogen.

Biology
2023

Management of Hantavirus Cardiopulmonary Syndrome in Critical Care Transport: A Review.

Air medical journal
2023

Novel Ozark Orthohantavirus in Hispid Cotton Rats (Sigmodon hispidus), Arkansas, USA.

Emerging infectious diseases
2023

Hantavirus: an overview and advancements in therapeutic approaches for infection.

Frontiers in microbiology
2023

Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker.

Viruses
2024

Filling the gaps in the Argentinian distribution of orthohantavirus: First finding of Lechiguanas virus in rodents from Corrientes, Argentina.

Zoonoses and public health
2023

Zoonotic Hantaviridae with Global Public Health Significance.

Viruses
2023

Detection of Hantavirus during the COVID-19 Pandemic, Arizona, USA, 2020.

Emerging infectious diseases
2024

Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study.

The Journal of infectious diseases
2023

Hantavirus in Panama: Twenty Years of Epidemiological Surveillance Experience.

Viruses
2023

Modeling potential risk areas of Orthohantavirus transmission in Northwestern Argentina using an ecological niche approach.

BMC public health
2023

Incidence of Orthohantavirus infection in humans follows observed changes in rodent reservoirs, Hubei Province, China (1984-2010).

American journal of veterinary research
2024

Design and validation of a novel multi-epitopes vaccine against hantavirus.

Journal of biomolecular structure & dynamics
2023

Hantavirus Infection in Children-A Pilot Study of Single Regional Center.

Viruses
2023

Hantavirus in humans: a review of clinical aspects and management.

The Lancet. Infectious diseases
2023

Andes Virus Genome Mutations That Are Likely Associated with Animal Model Attenuation and Human Person-to-Person Transmission.

mSphere
2023

Deciphering the Hantavirus Host Range Combining Virology and Species Distribution Models with an Emphasis on the Yellow Pygmy Rice Rat (Oligoryzomys flavescens).

Transboundary and emerging diseases
2023

Hantavirus Pulmonary Syndrome: 1993-2018.

The Pediatric infectious disease journal
2023

A Brief History of Bunyaviral Family Hantaviridae.

Diseases (Basel, Switzerland)
2023

Emerging Maripa Hantavirus as a Potential Cause of a Severe Health Threat in French Guiana.

The American journal of tropical medicine and hygiene
2020

[Environmental factors and cardiopulmonary syndrome due to hanta virus in Chile].

Revista de salud publica (Bogota, Colombia)
2022

Acute Hantavirus Infection Presenting With Fever and Altered Mentation in the Absence of Pulmonary or Renal Manifestations.

Open forum infectious diseases
2022

Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor.

Frontiers in pharmacology
2023

Modelling relative abundance of Oligoryzomys flavescens, an Orthohantavirus reservoir, in an endemic hantavirus pulmonary syndrome zone.

Zoonoses and public health
2022

Experimental Infection of Peromyscus Species Rodents with Sin Nombre Virus.

Emerging infectious diseases
2022

Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies.

Infectious diseases (London, England)
2022

[Prognostic factors for cardio-pulmonary syndrome and death by hantavirus Andes Sur: cohort study in San Carlos de Bariloche and health influence area].

Medicina
2022

Modeling of hantavirus cardiopulmonary syndrome.

Medwave
2022

Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations.

Viruses
2022

Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis.

Infection & chemotherapy
2022

Hantavirus Pulmonary Syndrome in a COVID-19 Patient, Argentina, 2020.

Emerging infectious diseases
2022

Favipiravir in the Battle with Respiratory Viruses.

Mini reviews in medicinal chemistry
2022

A Historical Perspective of Healthcare Disparity and Infectious Disease in the Native American Population.

The American journal of the medical sciences
2021

Influence of Climatic Factors on Human Hantavirus Infections in Latin America and the Caribbean: A Systematic Review.

Pathogens (Basel, Switzerland)
2022

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic.

The American journal of tropical medicine and hygiene
2022

Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review.

Infectious disorders drug targets
2022

Delayed viral clearance despite high number of activated T cells during the acute phase in Argentinean patients with hantavirus pulmonary syndrome.

EBioMedicine
2021

Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With Choclo orthohantavirus.

Frontiers in tropical diseases
2021

Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent.

PLoS neglected tropical diseases
2021

First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina.

EcoHealth
2021

Impact of Predator Exclusion and Habitat on Seroprevalence of New World Orthohantavirus Harbored by Two Sympatric Rodents within the Interior Atlantic Forest.

Viruses
2021

Viruses Run: The Evasion Mechanisms of the Antiviral Innate Immunity by Hantavirus.

Frontiers in microbiology
2022

Hantavirus Disease and COVID-19.

American journal of clinical pathology
2021

Novel infection of pericytes by Andes virus enhances endothelial cell permeability.

Virus research
2021

Hantaviruses in Agricultural and Forestry Workers: Knowledge, Attitudes and Practices in Italian Physicians.

Tropical medicine and infectious disease
2021

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species.

Journal of virology
2022

Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review.

The Journal of infectious diseases
2021

Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model.

Scientific reports
2021

[Controversies on corticosteroid therapy in hantavirus cardiopulmonary syndrome].

Medicina
2021

Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease.

Viruses
2021

Hantavirus infection-induced B cell activation elevates free light chains levels in circulation.

PLoS pathogens
2021

Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.

PLoS neglected tropical diseases
2021

Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2021

Binding of the Andes Virus Nucleocapsid Protein to RhoGDI Induces the Release and Activation of the Permeability Factor RhoA.

Journal of virology
2021

Continuing Orthohantavirus Circulation in Deer Mice in Western Montana.

Viruses
2021

Serological Evidence of Human Orthohantavirus Infections in Barbados, 2008 to 2016.

Pathogens (Basel, Switzerland)
2021

Sin Nombre virus prevalence from 2014-2017 in wild deer mice, Peromyscus maniculatus, on five of the California Channel Islands.

Zoonoses and public health
2021

Dengue and hantavirus coinfection with good outcomes: a clinical case from Panama.

BMJ case reports
2021

Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case reports in infectious diseases
2022

Expanded distribution of orthohantavirus Pergamino genotype: First record in Entre Rios province, Argentina.

Revista Argentina de microbiologia
2021

Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome.

Journal of medical virology
2021

Intersecting Paths of Emerging and Reemerging Infectious Diseases.

Emerging infectious diseases
2021

Occupations at risk of contracting zoonoses of public health significance in Québec.

Canada communicable disease report = Releve des maladies transmissibles au Canada
2021

The 1993 Hantavirus Pulmonary Syndrome Outbreak and Lessons for Today.

Medical journal (Fort Sam Houston, Tex.)
2021

Differential pathogenesis between Andes virus strains CHI-7913 and Chile-9717869in Syrian Hamsters.

Journal of virology
2021

Puumala Virus Infection in Family, Switzerland.

Emerging infectious diseases
2020

"Super-Spreaders" and Person-to-Person Transmission of Andes Virus in Argentina.

The New England journal of medicine
2020

Hantavirus pulmonary syndrome outbreaks associated with climate variability in Northwestern Argentina, 1997-2017.

PLoS neglected tropical diseases
2020

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture.

Frontiers in cellular and infection microbiology
2020

Cryofixation of Inactivated Hantavirus-Infected Cells as a Method for Obtaining High-Quality Ultrastructural Preservation for Electron Microscopic Studies.

Frontiers in cellular and infection microbiology
2020

Autochthonous Ratborne Seoul Virus Infection in Woman with Acute Kidney Injury.

Emerging infectious diseases
2020

Hantavirus Cardiopulmonary Syndrome in Canada.

Emerging infectious diseases
2020

Hantavirus Infections-Treatment and Prevention.

Current treatment options in infectious diseases
2020

Orthohantaviruses, Emerging Zoonotic Pathogens.

Pathogens (Basel, Switzerland)
2021

Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review.

Clinical and experimental pharmacology & physiology
2020

Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice.

Frontiers in cellular and infection microbiology
2020

[Influence factors related epidemics on hantavirus disease].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2020

Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report.

Journal of medical case reports
2020

Development of small-molecule inhibitors against hantaviruses.

Microbes and infection
2020

Home range variability, spatial aggregation, and excursions of Akodon azarae and Oligoryzomys flavescens in Pampean agroecosystems.

Integrative zoology
2020

Case 12-2020: A 24-Year-Old Man with Fever, Cough, and Dyspnea.

The New England journal of medicine
2020

Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014.

Emerging infectious diseases
2020

Sociocultural determinants of adoption of preventive practices for hantavirus: A knowledge, attitudes, and practices survey in Tonosí, Panama.

PLoS neglected tropical diseases
2020

Long-Term Rodent Surveillance after Outbreak of Hantavirus Infection, Yosemite National Park, California, USA, 2012.

Emerging infectious diseases
2020

New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome.

Zoonoses and public health
2020

Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2.

PLoS pathogens
2019

Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and/or Salivary Pathways.

Frontiers in microbiology
2020

Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019.

Emerging infectious diseases
2019

Development of RT-qPCR and semi-nested RT-PCR assays for molecular diagnosis of hantavirus pulmonary syndrome.

PLoS neglected tropical diseases
2019

Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil.

Revista do Instituto de Medicina Tropical de Sao Paulo
2019

[Estimates of the spatial distribution of the relative risk of mortality of the main zoonoses in Chile: Chagas disease, hydatidosis, Hantavirus cardiopulmonary syndrome and leptospirosis].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
2019

[Sociodemographic risk factors of hantavirus cardiopulmonary syndrome].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
2019

[Clinical laboratory criteria and its utility as predictive of diagnosis of the cardiopulmonary syndrome by hantavirus].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
2019

Mechanisms of Hantavirus Transmission in Oligoryzomys longicaudatus.

EcoHealth
2019

Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil.

Viruses
2020

Hantavirus Pulmonary Syndrome in Traveler Returning from Nepal to Spain.

Emerging infectious diseases
2019

Exotic Pinus radiata Plantations do not Increase Andes Hantavirus Prevalence in Rodents.

EcoHealth
2019

Clinical and anatomopathological aspects of patients with hantavirus cardiopulmonary syndrome in Uberaba, Minas Gerais, Brazil.

Revista do Instituto de Medicina Tropical de Sao Paulo
2019

Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution.

Viruses
2019

A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile.

Viruses
2019

Dendritic Cells (DCs) as "Fire Accelerants" of Hantaviral Pathogenesis.

Viruses
2019

New Exposure Location for Hantavirus Pulmonary Syndrome Case, California, USA, 2018.

Emerging infectious diseases
2019

Notes from the Field: Hantavirus Pulmonary Syndrome - Denver, Colorado, 2018.

MMWR. Morbidity and mortality weekly report
2019

Hantavirus entry: Perspectives and recent advances.

Advances in virus research
2019

Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome.

Viruses
2019

Hantavirus Pulmonary Syndrome Risk in Entre Ríos, Argentina.

EcoHealth
2019

Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses.

Viruses
2019

Current Situation and Perspectives on Hantaviruses in Mexico.

Viruses
2019

Progress on the Prevention and Treatment of Hantavirus Disease.

Viruses
2019

Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil.

International journal of environmental research and public health
2019

[HANTAVIRUS PULMONARY SYNDROME DIAGNOSED IN A RETURNED TRAVELER FROM THE USA].

Harefuah
2019

Detection of New World Hantavirus Antibodies in Rodents of Eastern New Mexico, USA.

Journal of wildlife diseases
2019

Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis.

BMC infectious diseases
2019

Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386.

Journal of virology
2019

Infection with New York Orthohantavirus and Associated Respiratory Failure and Multiple Cerebral Complications.

Emerging infectious diseases
2019

Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina.

Journal of medical virology
2019

An Overview of Zoonotic Disease Outbreaks and its Forensic Management Over Time.

Journal of forensic sciences
2019

Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus.

Viruses
2019

The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China.

PLoS neglected tropical diseases
2019

Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome.

The Journal of infectious diseases
2019

Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells.

Scientific reports
2019

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.

Journal of internal medicine
2019

Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors.

mBio
2018

Complete Genome Sequences of Monongahela Hantavirus from Pennsylvania, USA.

Microbiology resource announcements
2018

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Nature
2018

Notes from the Field: Exported Case of Sin Nombre Hantavirus Pulmonary Syndrome - Israel, 2017.

MMWR. Morbidity and mortality weekly report
2018

Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus.

Acta tropica
2018

Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana.

Emerging infectious diseases
2018

Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2018

Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay.

PloS one
2018

Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections.

The Journal of general virology
2018

Species diversity concurrently dilutes and amplifies transmission in a zoonotic host-pathogen system through competing mechanisms.

Proceedings of the National Academy of Sciences of the United States of America
2018

Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee.

The Permanente journal
2018

[Outbreak of hantavirus pulmonary syndrome in Tucumán, Argentina].

Medicina
2018

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Frontiers in cellular and infection microbiology
2018

Distributional ecology of Andes hantavirus: a macroecological approach.

International journal of health geographics
2018

Two Atypical Cases of Hantavirus Infections from Sri Lanka.

Case reports in infectious diseases
2018

A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome.

Journal of global infectious diseases
2018

Identification of tell-tale patterns in the 3' non-coding region of hantaviruses that distinguish HCPS-causing hantaviruses from HFRS-causing hantaviruses.

Emerging microbes & infections
2018

Hantavirus induced cardiopulmonary syndrome: A public health concern.

Journal of medical virology
2017

A rare cause of acute pancreatitis: Hantavirus infection.

Acta gastro-enterologica Belgica
2017

The Impact of Global Environmental Changes on Infectious Disease Emergence with a Focus on Risks for Brazil.

ILAR journal
2018

Space Use and Social Mating System of the Hantavirus Host, Oligoryzomys longicaudatus.

EcoHealth
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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

Não, trata-se de uma infecção aguda provocada por vírus do gênero Hantavirus. Ela não é transmitida geneticamente de pais para filhos e não possui mutações herdadas catalogadas.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

4 fontes citadas no texto · 7 publicações do grafo RarasNet (PubMed) · 5 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. MONDO
    purl.obolibrary.org
  2. GARD:69
    GARD (NIH)
  3. Q6137239
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (2026). Síndrome pulmonar por hantavírus. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/sindrome-pulmonar-por-hantavirus

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome pulmonar por hantavírus
Compêndio · Raras BR

Síndrome pulmonar por hantavírus

ORPHA:319247 · MONDO:0017879
CID-10
B33.4+ · Outras doenças por vírus não classificada em outra parte
CID-11
Ensaios
2 ativos
MedGen
UMLS
C0243025
EuropePMC
Wikidata
Wikipedia
Papers 10a
Evidência
🥉 Relato de caso

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Rara