Raras
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Alopecia fibrosante frontal
ORPHA:254492CID-10 · L66.1CID-11 · EA91.2DOENÇA RARA

Líquen plano é uma doença que afeta mucosa e pele e apresenta natureza inflamatória crônica, incidindo em cerca de 2% da população e acometendo de maneira mais usual mulheres acima dos 40 anos de idade.

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Introdução

O que você precisa saber de cara

📋

A alopécia fibrosante frontal (FFA) é uma variante rara de líquen planopilar (ver este termo), caracterizada por perda de cabelo em banda na região anterior, simétrica e progressiva.

Pesquisas ativas
4 ensaios
17 total registrados no ClinicalTrials.gov
Publicações científicas
810 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Adult
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: L66.1
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico810PubMed
Últimos 10 anos200publicações
Pico202587 papers
Linha do tempo
2026Hoje · 2026🧪 2015Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado3
2Fase 23
1Fase 11
·Pré-clínico9
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 16 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Alopecia fibrosante frontal

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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

17 ensaios clínicos encontrados, 4 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
701 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 701

#1

Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.

Annals of plastic surgery2026 Mar 19

Invasive and minimally invasive cosmetic procedures in patients with autoimmune or inflammatory skin disorders can carry an increased risk of surgical site infection, disease exacerbation, atrophic/hypertrophic scarring, or suboptimal cosmetic results. As facial procedures continue to rise in popularity, increasing complications are being reported in association with underlying dermatologic disease. In this review, we aim to bring attention to these dermatologic conditions and the potential challenges that they pose to the facial plastic surgeon. A comprehensive literature search was conducted across PubMed, Embase, and MEDLINE for articles published before January 2025 describing one or more patients with complications following facial or scalp procedures relating to a pre-existing or underlying dermatologic disorder or systemic condition with dermatologic manifestations. Articles were screened according to PRISMA guidelines, and data extraction included dermatologic disease diagnosis and severity, facial procedure performed, perioperative or postoperative complications, and resolution/treatment. Our search criteria identified 2452 articles; 53 articles met the inclusion criteria. In a total of 469 patients with pre-existing dermatologic conditions, mild-severe complications were reported after blepharoplasty (41/469, 8.7%), rhinoplasty (254/469, 54.2%), rhytidectomy (25/469, 5.3%), hair transplantation (37/469, 7.9%), cosmetic injections (35/469, 7.5%), lasers (15/469, 3.2%), and microneedling (50/469, 10.7%). Dermatologic disorders included acne, atopic dermatitis, frontal fibrosing alopecia, lichen planopilaris, rosacea, and vitiligo; systemic conditions with dermatologic manifestations included Ehlers-Danlos syndrome, sarcoidosis, scleroderma, and systemic or discoid lupus erythematosus. Complications ranged from mild postoperative disease exacerbation to severe hypertrophic scarring, ulcerations, and wound healing defects. The existing literature, while limited to case reports and small case series, demonstrates potential risks following facial procedures in patients with dermatologic disorders. This review highlights the importance of consideration of dermatologic disease in facial surgery planning and decision-making and summarizes effective strategies to minimize any potential risk.

#2

Frontal fibrosing alopecia and lichen planopilaris: epidemiology, treatment, and remission rate (2014-2024).

Dermatology reports2026 Mar 18

Frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) are cicatricial alopecia with overlapping but distinct epidemiological, clinical, and therapeutic features. This study evaluates their epidemiological and clinical characteristics, treatment approaches, and one-year remission rates. This retrospective cohort study was conducted at Holy Family Hospital, Karachi, Pakistan. Data from electronic records included demographics, clinical presentations, histology, treatments, outcomes, and follow-up. Patients of all ages and genders diagnosed with LPP or FFA between January 2014 and December 2024, with a minimum one-year follow-up, were included. LPP patients had a higher mean age at onset (53.1±9.42 years) than FFA patients (45.8±10.4 years; p=0.02). Scalp involvement was more common in LPP (95.9%), while body involvement was higher in FFA (85.7%; p<0.001). FFA patients had more symptoms, whereas LPP was often asymptomatic (p<0.001). Remission rates were similar at 12 months, but FFA showed higher long-term remission (59.0% vs. 39.0%; p=0.004). FFA patients sustained remission (55.7% vs. 23.4%; p<0.001), while LPP had more partial or no responses. This study highlighted key differences in demographics, clinical features, and treatments between FFA and LPP, with similarities in diagnostic delays and treatment approaches. Variations were noted in the age of onset, symptoms, clinical presentation, and outcomes.

#3

Revisiting Contact Sensitization Among Patients With LPP/FFA: Cross-Sectional Findings From 55 Cases.

Dermatitis : contact, atopic, occupational, drug2026 Mar 10

Lichen planopilaris (LPP) is an inflammatory disease results in scarring alopecia. Frontal fibrosing alopecia (FFA) is considered a variant due to similar histological features. A possible link has been suggested between exposure to various products and disease development, although research findings have been inconsistent. To assess the prevalence of delayed allergic reactions to commonly used topical agents in patients with LPP/FFA. A real-world observational study compared patch test results between LPP/FFA patients and a matched control group from routine clinical practice (2018-2023). Patch testing was conducted using the: European Baseline, Cosmetics, Hairdressing, and Sunscreen. The control group included patients without LPP/FFA underwent the same test panels. A total of 23 patients with FFA, 32 patients with LPP, and 171 controls were evaluated. Positive reactions in the European Baseline Series occurred in 26% of FFA patients, compared to 37% in the LPP patients and 56% in the control group. Common allergens included nickel and fragrance mix I, but their prevalence did not exceed rates in the general Israeli population. LPP/FFA patients had fewer positive reactions to cosmetics, hair products, and sunscreens. No clinically relevant reactions were demonstrated in the study. Patch test reactivity rates in LPP/FFA patients did not exceed those observed in the control group.

#4

Different Patterns of Lichen Planus in Three Members of One Family.

Case reports in dermatological medicine2026

The pathogenesis of Lichen Planus (LP) and its variants, despite many investigative efforts, remains incompletely understood. The occurrence of the disease in siblings suggests a potential role for both genetic and shared environmental factors. Here, three Iranian siblings-one male and two females-who presented with various clinical forms of LP were introduced. Case No. 1 exhibited bilateral facial pigmentation and was diagnosed with Lichen Planus Pigmentosus (LPPigm). Case No. 2 presented with facial pigmentation accompanied by facial papules and was diagnosed with LPPigm and Lichen Planopilaris (LPP). Case No.3 had frontotemporal hairline recession and eyebrow sparsening and was diagnosed with Frontal Fibrosing Alopecia (FFA). Histopathological examination confirmed the diagnoses in all three patients. Patients were treated with an individualized plan that included sunscreen use, potent topical corticosteroids, topical pimecrolimus, minoxidil, and systemic finasteride. To our knowledge, no other family in the literature has been reported to have such a wide range of LP variants. This series underscores the need for further research into genetic and environmental factors contributing to the development of LP and its variants.

#5

In vivo differentiation of scarring alopecia using line-field confocal optical coherence tomography: a pilot study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026 Jan 24

Diagnosing cicatricial alopecia is challenging. Even with histology, a definitive diagnosis cannot always be made. Line-field confocal optical coherence tomography (LC-OCT), a non-invasive imaging method with high resolution used in vivo, has proven helpful in diagnosing scarring alopecia. This study aims to evaluate the potential of LC-OCT for the differential diagnosis of different types of scarring alopecia. Images of 30 patients with scarring alopecia (10 Lichen planopilaris/Frontal fibrosing alopecia (LPP/FFA), 10 lupus erythematosus, 10 folliculitis decalvans/Folliculitis et perifolliculitis capitis suffodiens et abscedens (FD/FSA)) and 10 healthy controls were analyzed by two blinded independent examiners. Characteristic features and differential diagnoses were determined for each case. LC-OCT revealed distinct characteristics for each of the four subgroups, facilitating differential diagnosis with 100% sensitivity for lupus and 90% for LPP/FFA, FD/FSA, and the control group, and 100% specificity for LPP/FFA and 96.7% for the other groups. The features were used to generate a diagnostic algorithm tree. With LC-OCT, specific criteria can be used to differentiate between subtypes of scarring alopecia. These preliminary findings provide a basis for hypothesis generation, which should be further explored in larger cohorts and in longitudinal studies assessing treatment response over time.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC608 artigos no totalmostrando 187

2026

Lichen planopilaris versus frontal fibrosing alopecia: histopathologically distinct diseases or not?

Anais brasileiros de dermatologia
2026

Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.

Annals of plastic surgery
2026

Frontal fibrosing alopecia and lichen planopilaris: epidemiology, treatment, and remission rate (2014-2024).

Dermatology reports
2026

Revisiting Contact Sensitization Among Patients With LPP/FFA: Cross-Sectional Findings From 55 Cases.

Dermatitis : contact, atopic, occupational, drug
2026

Impact of GLP-1 and GLP-1/GIP agonists on healthcare resource utilization in individuals with scarring alopecias: A retrospective cohort analysis using TriNetX.

Journal of the American Academy of Dermatology
2026

Oral Tofacitinib for Refractory Lichen Planus Pigmentosus Coexisting with Frontal Fibrosing Alopecia.

Indian dermatology online journal
2026

Different Patterns of Lichen Planus in Three Members of One Family.

Case reports in dermatological medicine
2025

Histopathological characterization of inflammatory interparietal involvement in frontal fibrosing alopecia.

Frontiers in medicine
2026

This month in JAAD: April 2026.

Journal of the American Academy of Dermatology
2026

Highlights from JAADReviews: April 2026-Frontal fibrosing alopecia across sexes.

Journal of the American Academy of Dermatology
2026

In vivo differentiation of scarring alopecia using line-field confocal optical coherence tomography: a pilot study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2026

Frontal Fibrosing Alopecia and Its Association With Genital Lichen Planus and Lichen Sclerosus: A Systematic Review.

International journal of dermatology
2026

Central centrifugal cicatricial alopecia is associated with longer time to diagnosis among scarring alopecias.

JAAD international
2026

Line Field Confocal Optical Coherence Tomography (LC-OCT) Features of Primary Cicatricial Alopecias.

International journal of dermatology
2026

No elevated risk for osteoporosis or osteopenia among women with androgenetic or frontal fribrosing alopecia treated with 5-alpha reductase inhibitors: A retrospective TriNetX cohort study.

Journal of the American Academy of Dermatology
2026

Racial and ethnic differences in the prevalence of frontal fibrosing alopecia in a large integrated healthcare system.

Journal of the American Academy of Dermatology
2025

Hair Care Habits and Frontal Fibrosing Alopecia: A Case-Control Study.

Skin appendage disorders
2026

Consensus Document on the Clinical Management of Frontal Fibrosing Alopecia: Recommendations From Spanish Working Group on Trichology and Onychology of the AEDV.

Actas dermo-sifiliograficas
2026

Menopause and Common Dermatoses: A Systematic Review.

American journal of clinical dermatology
2026

Salicylate Allergy and Frontal Fibrosing Alopecia: A Case Report With Stabilisation of the Complaints After Allergen Avoidance.

Contact dermatitis
2025

Peroxisome Proliferator-activated Receptor Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study.

International journal of trichology
2025

Multiple-Site Lichen Planus: An Italian Case Series of 44 Patients.

Journal of clinical medicine
2025

Vitiligo developing in concurrence with frontal fibrosing alopecia.

Proceedings (Baylor University. Medical Center)
2026

Frontal Fibrosing Alopecia and Titanium: Uncovering Hidden Exposures.

International journal of dermatology
2025

Microinfusion of medications into the skin as a drug delivery technique: a narrative review.

Dermatology reports
2025

Primary cutaneous follicle center lymphoma presenting as frontal fibrosing alopecia.

Dermatology online journal
2025

Randomized Controlled Trial of the Topical Jak Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia.

The Journal of investigative dermatology
2025

A systematic review of procedural modalities in the treatment of lichen planopilaris, frontal fibrosing alopecia, and discoid lupus erythematosus.

Lasers in medical science
2025

A phase 2b basket trial approach to treat multiple rare and fibrotic skin diseases.

Frontiers in medicine
2025

Evaluating Scarring Alopecia Therapies from the Patient Perspective: Knowledge, Barriers to Care, and Treatment Satisfaction.

Skin appendage disorders
2025

Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety.

Skin appendage disorders
2026

Investigation of concordance between scalp symptoms, disease severity, and inflammatory activity in scarring alopecias.

Journal of the American Academy of Dermatology
2025

Micronutrient levels and thyroid functions in scarring alopecias: Do they play a role in disease pathogenesis?

Cutaneous and ocular toxicology
2025

Comorbidities in primary cicatricial alopecia: a systematic review and meta-analysis.

Frontiers in immunology
2025

The efficacy and tolerability of low-dose naltrexone in the treatment of lichen planopilaris and frontal fibrosing alopecia: A systematic review.

Journal of the American Academy of Dermatology
2025

Eyebrow alopecia in frontal fibrosing alopecia: A clinical and histopathological study of 25 patients.

Journal of the American Academy of Dermatology
2025

Glabellar Clinical and Trichoscopic Findings in Patients with Frontal Fibrosing Alopecia.

Skin appendage disorders
2025

Highlights from JAAD Reviews: November 2025: Frontal fibrosing alopecia in males.

Journal of the American Academy of Dermatology
2025

Unravelling the transcriptomic landscape of primary lymphocytic scarring alopecias: systematic review and meta-analysis.

Frontiers in immunology
2025

Increased serum leptin levels are potentially related to male frontal fibrosing alopecia.

Journal of the American Academy of Dermatology
2025

Three types of alopecia in one patient: A case of central centrifugal cicatricial alopecia, alopecia areata, and telogen effluvium.

JAAD case reports
2025

Frontal Fibrosing Alopecia Colocalized With Vitiligo.

The Journal of dermatology
2026

Statement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Forehead atrophy in frontal fibrosing alopecia: An ultrasonographic and histopathological study of 10 patients.

Journal of the American Academy of Dermatology
2025

Frequency of Types of Alopecia in a Single-centre Hair Referral Clinic Over a Ten Years Period.

International journal of trichology
2025

Frontal Fibrosing Alopecia and Titanium Dioxide Nanoparticles.

International journal of dermatology
2025

Hair Transplant in Patchy Scarring Alopecia of the Fronto-Temporal Area.

Skin appendage disorders
2025

Comorbidities Associated With Lichen Planopilaris: A Systematic Review and Meta-Analysis.

International journal of dermatology
2025

FFA Patient Profile Analysis Based on the Authors' Observations and a Review of the Literature-An Original Survey.

Journal of clinical medicine
2025

Cross-Sectional Analysis of Subclinical Findings Using High-Frequency Ultrasound in Frontal Fibrosing Alopecia.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
2025

Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review.

Archives of dermatological research
2025

Alopecia: A Google Trends Analysis of the Past 5 Years (2018-2023).

Skin appendage disorders
2025

The 100 Most-Cited Publications in Lichen Planopilaris: A Bibliometric Analysis.

Skin appendage disorders
2025

Methodological concerns in 'dutasteride in the treatment of frontal fibrosing alopecia'.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Acquired Idiopathic Generalized Anhidrosis and Frontal Fibrosing Alopecia: Possible Evidence for a Shared Autoimmune Pathogenesis.

International journal of dermatology
2025

Odds of developing frontal fibrosing alopecia more closely tied to affluence than race - A retrospective cohort study.

Journal of the American Academy of Dermatology
2025

Uterine and ovarian pathologies among patients with lichen planopilaris and frontal fibrosing alopecia.

Clinical and experimental dermatology
2025

Menopause and hair loss in women: Exploring the hormonal transition.

Maturitas
2025

Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.

Acta dermato-venereologica
2025

Forehead Reduction Surgery: Outcomes and Complications of 650 Cases in a Multiracial Population.

Aesthetic plastic surgery
2025

Delphi Consensus on the Distinct Clinical and Histopathological Features of Lichen Planopilaris and Frontal Fibrosing Alopecia: Insights From the Hair Diseases EADV Task Force.

International journal of dermatology
2025

Lichen Planopilaris and the Lichen Planopilaris Mimickers: A Systematic Review.

International journal of dermatology
2025

The Frontal Fibrosing Alopecia Syndrome: How a Single Word Name Change Might Change So Much.

International journal of dermatology
2025

Concomitant Allergic Contact Dermatitis and Frontal Fibrosing Alopecia: A Potential Trigger for Relapse or Onset?

Skin appendage disorders
2025

Efficacy of Methotrexate Microinfusion in Scalp Lesions of Patients with Frontal Fibrosing Alopecia: A Prospective Controlled Trial.

Skin appendage disorders
2025

Familial Frontal Fibrosing Alopecia Occurs Early in Daughters With Affected Mothers: A Case Report and a Review of the Literature.

The Australasian journal of dermatology
2025

Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates.

Indian journal of dermatology
2025

"Effects of Allergen Avoidance in Patients with Frontal Fibrosing Alopecia: A Retrospective Cohort Analysis".

Dermatitis : contact, atopic, occupational, drug
2025

Frontal Fibrosing Alopecia in Men: A Review of the Literature.

Journal of clinical medicine
2025

Environmental factors and the development of frontal fibrosing alopecia: insight from a retrospective case-control investigation.

Archives of dermatological research
2025

Trichoscopic Features of Lichen Planopilaris versus Frontal Fibrosing Alopecia: A Systematic Review.

Dermatology practical &amp; conceptual
2025

Efficacy and tolerability of low-dose versus high-dose doxycycline in the management of lymphocytic scarring alopecias.

Journal of the American Academy of Dermatology
2025

Frontal Fibrosing Alopecia Treated With Nanofat Injections.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2025

Efficacy and safety of JAK inhibitors in treating lichen planopilaris or frontal fibrosing alopecia.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

[Translated article] Low-dose Oral Minoxidil for Frontal Fibrosing Alopecia: A 122-patient Case Series.

Actas dermo-sifiliograficas
2025

Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis.

JAMA dermatology
2025

Clinical Implications of Genetic Discoveries on Frontal Fibrosing Alopecia.

JAMA dermatology
2025

Oral dutasteride can be considered a first-line treatment for frontal fibrosing alopecia until high-quality clinical trials could show better results with other therapies.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Efficacy, safety and tolerability of drugs for alopecia: a comprehensive review.

Expert opinion on drug metabolism &amp; toxicology
2025

Histologic absence of yeast as a clue for classic lichen planopilaris, fibrosing alopecia in a pattern distribution, and frontal fibrosing alopecia: A cross-sectional observational study.

JAAD international
2025

Ethical considerations in the treatment of frontal fibrosing alopecia: Addressing a Patient's preference for hair transplant over medical management.

Journal of the American Academy of Dermatology
2026

Frontal fibrosing alopecia part I - Diagnosis and clinical presentation.

Journal of the American Academy of Dermatology
2026

Frontal fibrosing alopecia part II: Etiopathogenesis and management.

Journal of the American Academy of Dermatology
2025

Concerns regarding the systematic review and editorial on oral dutasteride for frontal fibrosing alopecia.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Assessing the normality of the frontal hairline: a comparison of women with frontal fibrosing alopecia and women with a normal scalp.

Clinical and experimental dermatology
2025

Application of Ultraviolet-Induced Fluorescence Trichoscopy (UVFT) in Hair and Scalp Diseases.

Dermatology and therapy
2025

A single-center retrospective cohort study of hydroxychloroquine-related adverse events in adults with lymphocytic cicatricial alopecia.

Journal of the American Academy of Dermatology
2025

Frontal Fibrosing Alopecia: An Update.

American journal of clinical dermatology
2024

Clinicopathological Features of Frontal Fibrosing Alopecia (FFA) in 26 females: A Retrospective Study.

Iranian journal of pathology
2024

Light-based therapies in the treatment of alopecia.

Dermatology online journal
2025

Line-field confocal optical coherence tomography in lichen planopilaris and frontal fibrosing alopecia: A pilot study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2024

Trichoscopy of Frontal Fibrosing Alopecia in Caucasians: A Review.

Skin appendage disorders
2024

Assessment and Validity of Trichoscopy for Eyebrow Involvement in Lichen Planopilaris and Frontal Fibrosing Alopecia: A Case-Control Study.

Dermatology practical &amp; conceptual
2024

Off-label dermatologic uses of IL-23 inhibitors.

The Journal of dermatological treatment
2025

Frontal Fibrosing Alopecia: A Comprehensive Guide for Cosmetic Dermatologists.

Dermatology and therapy
2025

Exploring the relationship between lichen planopilaris and skin cancer.

International journal of dermatology
2024

Clinical and demographic characteristics of frontal fibrosing alopecia in a dermatology referral center in Bogota, Colombia: a descriptive cross-sectional study.

International journal of women's dermatology
2025

Translation, cultural adaptation and validation of the Brazilian version of the Frontal Fibrosing Alopecia Quality of Life Index (FFA-QLI-BRA).

Anais brasileiros de dermatologia
2025

Haircare practices and scarring alopecia: a survey study.

International journal of dermatology
2024

Differential diagnosis of posterior scalp hair loss.

Archives of dermatological research
2025

Gonadocorticoid exposure is associated with increased odds of lichen planopilaris and frontal fibrosing alopecia: A large retrospective cohort study.

Journal of the American Academy of Dermatology
2025

A phase 2a trial of brepocitinib for cicatricial alopecia.

Journal of the American Academy of Dermatology
2024

Is Frontal Fibrosing Alopecia Connected to Sunscreen Usage?

Cutis
2025

Beyond the forehead: nuchal papules and ectatic veins in frontal fibrosing alopecia.

International journal of dermatology
2024

Trichoscopy of Frontal Fibrosing Alopecia Affecting Black Scalp: A Literature Review.

Skin appendage disorders
2025

Tacrolimus 0.3% cream in the treatment of frontal fibrosing alopecia: a prospective observational study.

International journal of dermatology
2025

Send in the clowns: A special tribute to medical clowning and clown eponyms in dermatology.

Clinics in dermatology
2025

Topical ruxolitinib in the management of frontal fibrosing alopecia and/or lichen planopilaris: A single-center retrospective cohort study.

Journal of the American Academy of Dermatology
2025

Analysis of breast health outcomes in women on oral 5-alpha reductase inhibitors: A single-center retrospective cohort study.

Journal of the American Academy of Dermatology
2024

Lichen planopilaris is associated with cardiovascular risk reduction: a retrospective cohort review.

International journal of women's dermatology
2024

Oral naltrexone in the treatment of lichen planopilaris and frontal fibrosing alopecia.

Archives of dermatological research
2024

Oral gabapentin for scalp pruritus in patients with lichen planopilaris: A case series.

JAAD case reports
2024

Evaluation of hair surface structure and morphology of patients with lichen planopilaris (LPP) by atomic force microscopy (AFM).

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2024

Extra-follicular cutaneous manifestations of frontal fibrosing alopecia.

Anais brasileiros de dermatologia
2024

Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective, Real-Life Analysis in a Tertiary Center in Germany.

Journal of clinical medicine
2024

Pruritus in Lichen Planopilaris and Frontal Fibrosing Alopecia-Clinical Characteristics and Dermoscopic Correlations.

Journal of clinical medicine
2023

Symmetric Idiopathic MicroPapular Facial Eruption or SIMPLE - Description of a New Entity Featuring Facial Vellus Hair Lichen Planopilaris in the Absence of Frontal Fibrosing Alopecia.

International journal of trichology
2025

A practical guide to the standardization of hair loss photography for clinicians.

Clinical and experimental dermatology
2024

Quality-of-life assessment and the impact of early diagnosis and treatment in lichen planopilaris: a systematic review.

Clinical and experimental dermatology
2024

The use of topical ruxolitinib 1.5% cream in frontal fibrosing alopecia: A case report.

JAAD case reports
2024

Characteristics of pruritus in lichen planopilaris and frontal fibrosing alopecia: A cohort study in a French hospital.

Journal of the American Academy of Dermatology
2024

Janus Kinase Inhibitor Therapy for Cicatricial Alopecias: An Evidence-Based Review.

Journal of cutaneous medicine and surgery
2024

Oral dutasteride is a first-line treatment for frontal fibrosing alopecia.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

Slowed-down temporal vein refilling as diagnostic pearl in frontal fibrosing alopecia.

Journal of the American Academy of Dermatology
2024

Isotretinoin as a promising option in the treatment of facial papules of frontal fibrosing alopecia.

International journal of dermatology
2024

Coexistent frontal fibrosing alopecia with ophiasis pattern alopecia areata in a young female: A case report and review of the literature.

Clinical case reports
2024

A plausible hypothesis for the clinical pattern of frontal fibrosing alopecia: The persistence of residues of leave-on facial products on hairline and eyebrows.

Journal of cosmetic dermatology
2024

Frontal fibrosing alopecia-A new absolute contraindication for deep chemical peels.

Clinics in dermatology
2024

Upregulation of caveolae-associated structural proteins in the hair follicle bulge of lichen planopilaris and frontal fibrosing alopecia.

Archives of dermatological research
2024

Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies.

Dermatology and therapy
2024

The "Watch Sign" - Another Observation in the Course of Male Frontal Fibrosing Alopecia.

Dermatology practical &amp; conceptual
2024

Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia.

JAMA dermatology
2024

Prevalence of lichen planopilaris and frontal fibrosing alopecia in the United States: an All of Us database analysis.

International journal of dermatology
2024

Navigating Diagnostic Uncertainty: Frontal Fibrosing Alopecia Versus Keratosis Pilaris Atrophicans Faciei With Genetic Testing Insights.

Cureus
2024

Common contact allergens implicated in frontal fibrosing alopecia found in over-the-counter hair growth serums and solutions.

International journal of women's dermatology
2025

Sunscreens part 2: Regulation and safety.

Journal of the American Academy of Dermatology
2024

Temporary tattoos as a low-cost, quick-fix, for eyebrow madarosis.

Journal of the American Academy of Dermatology
2025

Patch Testing and Allergic Contact Dermatitis in Patients with Lichen Planopilaris and/or Frontal Fibrosing Alopecia: A Systematic Reviewand Meta-Analysis.

Dermatitis : contact, atopic, occupational, drug
2024

Tangled Truths: Unraveling the Link Between Frontal Fibrosing Alopecia and Allergic Contact Dermatitis.

Cutis
2024

Frontal Fibrosing Alopecia-Related Facial Papules Successfully Treated With a Thermomechanical Fractional Injury Device.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2024

Updates on disorders in curly hair.

International journal of dermatology
2024

The Frontal Fibrosing Alopecia Treatment Dilemma.

Journal of clinical medicine
2024

Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation.

JID innovations : skin science from molecules to population health
2024

Impact of drug withdrawal on frontal fibrosing alopecia: An observational study of 83 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

Commentary on picosecond Nd:YAG laser therapy for pigmentation due to lichen planus pigmentosus in a patient with skin of color.

JAAD case reports
2024

Review of the use of Janus kinase inhibitors in the treatment of scarring alopecia.

International journal of dermatology
2024

Correlation of clinical and trichoscopy features with the degree of histologic inflammation in lichen planopilaris and frontal fibrosing alopecia in a cross-sectional study.

Journal of the American Academy of Dermatology
2024

Attenuation of disease process following treatment with low-dose naltrexone in patients with frontal fibrosing alopecia and lichen planopilaris: A retrospective study.

Journal of the American Academy of Dermatology
2024

Highlighting the Link Between Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia.

Journal of drugs in dermatology : JDD
2024

Safety and Efficacy of Minoxidil Treatment in Scarring Alopecia: A Scoping Review.

Journal of drugs in dermatology : JDD
2024

A review of isotretinoin in the treatment of frontal fibrosing alopecia.

Journal of cosmetic dermatology
2025

Stabilization of frontal fibrosing alopecia with topical latanoprost monotherapy.

JAAD case reports
2024

Lichen planopilaris and frontal fibrosing alopecia-associated conditions: A retrospective study with 241 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

A Retrospective Study of Frontal Fibrosing Alopecia from North-East India.

Indian journal of dermatology
2024

Is there a Rationale for the Use of Lymecycline for Frontal Fibrosing Alopecia?

Dermatology practical &amp; conceptual
2024

Dutasteride in the treatment of frontal fibrosing alopecia: Systematic review and meta-analysis.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

JAK Inhibitors in the Treatment of Lichen Planopilaris.

Skin appendage disorders
2024

Topical tofacitinib for patients with lichen planopilaris and/or frontal fibrosing alopecia.

Journal of the American Academy of Dermatology
2024

HLA-B alleles associated with frontal fibrosing alopecia in Brazil may share similar peptide presentation and T-cell interaction profiles.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

Graham Little-Piccardi-Lassueur Syndrome with Frontal Fibrosing Alopecia in an Adolescent Girl: A Rare Presentation.

Indian dermatology online journal
2024

Frontal Fibrosing Alopecia and Reproductive Health: Assessing the Role of Sex Hormones in Disease Development.

Journal of personalized medicine
2024

The treatment of primary cicatricial alopecia is challenging.

Journal of the American Academy of Dermatology
2024

New Histopathologic Findings in Scarring Alopecias: The Role of Adipose Tissue and Eccrine Sweat Coils in Frontal Fibrosing Alopecia, Fibrosing Alopecia in a Pattern Distribution, and Lichen Planopilaris.

Archives of pathology &amp; laboratory medicine
2024

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study.

International journal of dermatology
2024

Endocrine and metabolic comorbidities in primary cicatricial alopecia: A nationwide population-based study.

The Journal of dermatology
2023

Use of Hydroxychloroquine in Hair Disorders.

Skin appendage disorders
2023

Coexistence of Lichen Planus Pigmentosus and Classic Lichen Planopilaris: A Case Report and Literature Review.

Cureus
2024

Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle.

Contact dermatitis
2023

Folliculitis Decalvans with Frontal Fibrosing Alopecia in a Dark Phototype: Presentation of Folliculitis Decalvans and Lichen Planopilaris Phenotypic Spectrum.

Dermatology practical &amp; conceptual
2024

Reflections on frontal fibrosing alopecia in artworks.

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia.

Acta dermato-venereologica
2023

Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature.

JAAD case reports
2024

Clinical effectiveness of finasteride versus hydroxychloroquine in the treatment of frontal fibrosing alopecia: A randomized controlled trial.

Journal of cosmetic dermatology
2023

Diffuse hair loss in a patient with systemic lupus erythematosus.

JAAD case reports
2023

Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias.

Clinical, cosmetic and investigational dermatology
2023

The dermatoscope in the hair clinic: Trichoscopy of scarring and nonscarring alopecia.

Journal of the American Academy of Dermatology
2023

Correlation of clinical, histopathologic, and direct immunofluorescence findings in lesional and nonlesional scalp of frontal fibrosing alopecia and lichen planopilaris - An observational study.

JAAD international
2023

Beard Alopecia: An Updated and Comprehensive Review of Etiologies, Presentation and Treatment.

Journal of clinical medicine
2023

Frontal fibrosing alopecia coexisting with vitiligo: is there a true association?

Anais brasileiros de dermatologia
2023

Hairlines through history: Frontal fibrosing alopecia over 500 years?

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

Frontal fibrosing alopecia: report of four sisters.

Anais brasileiros de dermatologia
2023

Identifying first-degree family members in patients with frontal fibrosing alopecia and lichen planopilaris in a specialty alopecia clinic.

International journal of women's dermatology
2024

Cetrimonium Bromide Patch Test Positivity Is Found With a High Frequency in a Cohort of Patients With Frontal Fibrosing Alopecia.

Dermatitis : contact, atopic, occupational, drug
2023

Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review.

Dermatology and therapy
2023

Allergic contact dermatitis to drometrizole trisiloxane in a woman thereafter diagnosed with frontal fibrosing alopecia.

Contact dermatitis
2023

Histopathologic Spectrum of Alopecias Seen in a Jamaican Setting.

The American Journal of dermatopathology
2023

Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases.

Life (Basel, Switzerland)
Ver todos os 608 no EuropePMC

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Comunidades

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Doenças relacionadas

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Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.
    Annals of plastic surgery· 2026· PMID 41848703mais citado
  2. Frontal fibrosing alopecia and lichen planopilaris: epidemiology, treatment, and remission rate (2014-2024).
    Dermatology reports· 2026· PMID 41848414mais citado
  3. Revisiting Contact Sensitization Among Patients With LPP/FFA: Cross-Sectional Findings From 55 Cases.
    Dermatitis : contact, atopic, occupational, drug· 2026· PMID 41805012mais citado
  4. Different Patterns of Lichen Planus in Three Members of One Family.
    Case reports in dermatological medicine· 2026· PMID 41669758mais citado
  5. In vivo differentiation of scarring alopecia using line-field confocal optical coherence tomography: a pilot study.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG· 2026· PMID 41580902mais citado
  6. Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.
    Front Med (Lausanne)· 2026· PMID 41987782recente
  7. Successful Hair Regrowth in Early Frontal Fibrosing Alopecia With Combination Therapy.
    Cureus· 2026· PMID 41943777recente
  8. Contact Sensitization in Patients With Frontal Fibrosing Alopecia: Patch Test Results With an Extended Baseline Series in Consecutive Patients.
    Contact Dermatitis· 2026· PMID 41942283recente
  9. Frontal Fibrosing Alopecia and Cyclines in Skin of Color Patients: A Retrospective Study of 50 Patients.
    Skin Appendage Disord· 2026· PMID 41938990recente
  10. Risk of Psychiatric Comorbidities in Non-Scarring Versus Scarring Alopecia: A Retrospective Cohort Study.
    J Cutan Med Surg· 2026· PMID 41925130recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:254492(Orphanet)
  2. MONDO:0016776(MONDO)
  3. GARD:10886(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q2308637(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Alopecia fibrosante frontal
Compêndio · Raras BR

Alopecia fibrosante frontal

ORPHA:254492 · MONDO:0016776
Prevalência
Unknown
CID-10
L66.1 · Líquen planopilar
CID-11
Ensaios
4 ativos
Início
Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C1274700
EuropePMC
Wikidata
Papers 10a
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