Raras
Buscar doenças, sintomas, genes...
Astrocitoma difuso
ORPHA:251595CID-10 · D33.2CID-11 · 2A00.0YDOENÇA RARA

Um tipo de tumor cerebral, o astrocitoma, que é considerado de baixo grau (grau II pela Organização Mundial da Saúde - OMS). Ele se caracteriza por se espalhar de forma difusa pelas estruturas vizinhas do sistema nervoso central (cérebro e medula espinhal). Esses tumores geralmente afetam adultos jovens e têm a tendência de progredir para formas mais agressivas, como o astrocitoma anaplásico e o glioblastoma. Com base na presença ou ausência de uma mutação nos genes IDH, os astrocitomas difusos são classificados como: IDH-mutante, IDH-tipo selvagem (quando não há a mutação) e não especificado de outra forma.

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Introdução

O que você precisa saber de cara

📋

Um tipo de tumor cerebral, o astrocitoma, que é considerado de baixo grau (grau II pela Organização Mundial da Saúde - OMS). Ele se caracteriza por se espalhar de forma difusa pelas estruturas vizinhas do sistema nervoso central (cérebro e medula espinhal). Esses tumores geralmente afetam adultos jovens e têm a tendência de progredir para formas mais agressivas, como o astrocitoma anaplásico e o glioblastoma. Com base na presença ou ausência de uma mutação nos genes IDH, os astrocitomas difusos são classificados como: IDH-mutante, IDH-tipo selvagem (quando não há a mutação) e não especificado de outra forma.

Pesquisas ativas
11 ensaios
83 total registrados no ClinicalTrials.gov
Publicações científicas
514 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.48
United States
Início
Adolescent
+ adult, childhood
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D33.2
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico514PubMed
Últimos 10 anos200publicações
Pico202141 papers
Linha do tempo
2026Hoje · 2026🧪 1994Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição.

IDH2Isocitrate dehydrogenase [NADP], mitochondrialCandidate gene tested inAltamente restrito
FUNÇÃO

Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140)

LOCALIZAÇÃO

Mitochondrion

VIAS BIOLÓGICAS (4)
Citric acid cycle (TCA cycle)Maturation of TCA enzymes and regulation of TCA cycleMitochondrial protein degradationTranscriptional activation of mitochondrial biogenesis
MECANISMO DE DOENÇA

D-2-hydroxyglutaric aciduria 2

A neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.

EXPRESSÃO TECIDUAL(Ubíquo)
Músculo esquelético
442.8 TPM
Coração - Ventrículo esquerdo
311.5 TPM
Rim - Medula
273.8 TPM
Linfócitos
186.0 TPM
Fígado
184.7 TPM
OUTRAS DOENÇAS (13)
d-2-hydroxyglutaric aciduria 2anaplastic oligodendrogliomagemistocytic astrocytomaoligoastrocytoma
HGNC:5383UniProt:P48735

Variantes genéticas (ClinVar)

82 variantes patogênicas registradas no ClinVar.

🧬 IDH2: GRCh38/hg38 15q26.1-26.3(chr15:90068508-101888837)x3 ()
🧬 IDH2: NM_002168.4(IDH2):c.800A>G (p.Gln267Arg) ()
🧬 IDH2: GRCh37/hg19 15q26.1-26.3(chr15:90569376-102369410)x1 ()
🧬 IDH2: NM_002168.4(IDH2):c.448G>C (p.Glu150Gln) ()
🧬 IDH2: NM_002168.4(IDH2):c.1081-60C>G ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 1 variantes classificadas pelo ClinVar.

1
Patogênica (100.0%)
VARIANTES MAIS SIGNIFICATIVAS
NF1: NM_001042492.3(NF1):c.1020dup (p.Val341fs) [Pathogenic]
NF1: NM_001042492.3(NF1):c.7669C>T (p.Gln2557Ter) []

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
2Fase 210
1Fase 16
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Astrocitoma difuso

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

83 ensaios clínicos encontrados, 11 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
332 papers (10 anos)
#1

Eloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery.

Surgical neurology international2026

Awake craniotomy with intraoperative mapping remains the gold standard for resection of gliomas in eloquent brain regions, enabling functional preservation while maximizing tumor removal. Recent advances in brain connectomics provide a connectivity-based approach, complementing traditional localization strategies by visualizing patient-specific structural and functional networks. We report the first Latin American case of diffuse glioma resection in the motor cortex using connectome-guided neuronavigation combined with awake functional monitoring. A 43-year-old male presented with focal motor seizures affecting the left upper limb. Preoperative magnetic resonance imaging revealed a motor-eloquent lesion. Patient-specific connectome parcellation identified intratumoral motor parcels, guiding surgical approach planning. During awake craniotomy, intraoperative mapping confirmed motor activation sites, enabling selective resection. Surgery was halted upon detecting transient monoparesis (3/5, Daniels scale) to preserve function. Postoperative recovery was complete within 2 weeks. Pathology confirmed the World Health Organization grade 2 diffuse astrocytoma. This case illustrates the synergistic potential of connectome-guided neuronavigation and awake surgery in achieving a balance between oncologic and functional goals. Connectomics enhances preoperative planning by delineating individualized cortical-subcortical networks, even in anatomically distorted brains. Awake mapping provides real-time functional verification, mitigating limitations such as brain shift and resolution constraints inherent to navigation alone. While evidence is still limited to small series, this integrated approach offers a promising avenue for safe maximal resection in eloquent gliomas. Further studies are needed to validate its impact on long-term functional and oncologic outcomes.

#2

A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report.

BMC neurology2026 Mar 23
#3

Exploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.

Cancer letters2026 Mar 11

Metabolic reprogramming is a defining hallmark of cancer, and brain tumors are no exception. The brain's extraordinary energy demands, metabolic compartmentalization, and protection by the blood-brain barrier create a unique microenvironment that profoundly shapes tumor metabolism. Many brain tumors exhibit enhanced glucose uptake and fermentative glycolysis, a phenomenon classically described as the Warburg effect. However, accumulating evidence over the past two decades reveals that brain tumors rely on a far broader and more dynamic metabolic repertoire. Beyond glycolysis, metabolic processes such as the pentose phosphate pathway, serine biosynthesis, tricarboxylic acid cycle, oxidative phosphorylation, glutaminolysis, lipid metabolism, and purine and pyrimidine biosynthesis, all contribute to sustaining tumor growth, stemness, epigenetic identity, and therapeutic resistance. These metabolic adaptations differ markedly across tumor types and developmental contexts, from glioblastoma and diffuse astrocytoma to oligodendroglioma, ependymoma, pediatric high-grade glioma, medulloblastoma, and other embryonal tumors. In this review, we provide an overview of the current understanding of the major metabolic hallmarks of brain cancer, emphasizing mechanisms that support tumor identity, proliferation, and survival. We further highlight emerging metabolic vulnerabilities and discuss progress in developing therapies that target these pathways. Together, these insights illuminate how metabolism underpins the remarkable adaptability of brain tumors and suggest new avenues for precision treatment.

#4

Pediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.

Pediatric radiology2026 Jan 27

Low-grade epilepsy-associated tumors (LEATs) are a distinct group of tumors commonly encountered in pediatric drug-resistant epilepsy that necessitate surgical intervention. Like tumors elsewhere in the central nervous system, molecular characterization is becoming an increasingly important consideration in pediatric neuro-oncology prognostication and management for LEATs. Thus, familiarity with relevant tumor mutations and radiogenomic features of LEATs is important for radiologists caring for affected patients. This article will review the genetic alterations and imaging characteristics of LEATs, formatted according to the three categories defined by the World Health Organization (WHO): glioneuronal and neuronal tumors (ganglioglioma, dysembryoplastic neuroepithelial tumor, papillary glioneuronal tumor, multinodular and vacuolating neuronal tumor); circumscribed astrocytic gliomas (pilocytic astrocytoma, pleomorphic xanthoastrocytoma); and pediatric-type diffuse low-grade gliomas (diffuse astrocytoma MYB or MYBL1-altered, angiocentric glioma, diffuse low-grade glioma MAPK pathway-altered, polymorphous low-grade neuroepithelial tumor of the young).

#5

Pediatric Diffuse Low-Grade Gliomas: Radiology, Symptoms, Treatment, and Molecular Pathways.

Neuroimaging clinics of North America2026 Feb

Pediatric diffuse low-grade gliomas (LGGs) are heterogeneous group of central nervous system tumors that typically exhibit a relatively benign clinical course. These tumors represent a unique classification in pediatric neuro-oncology, distinct from adult counterparts in terms of biological behavior, molecular pathways, and clinical presentation. The evolving World Health Organization classification system has increasingly relied on combination of histopathologic, genetic, and radiologic criteria to define and distinguish among pediatric glioma subtypes. This article aims to synthesize current knowledge regarding the clinical, molecular, and radiologic features of these pediatric diffuse LGGs and highlights the nuances in diagnosis, treatment approaches, and prognostic outlook.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC87 artigos no totalmostrando 196

2026

A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report.

BMC neurology
2026

Exploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.

Cancer letters
2026

Eloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery.

Surgical neurology international
2026

Pediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.

Pediatric radiology
2025

Treatment differences in IDH-wildtype glioma - the impact of surgery and adjuvant therapy.

Journal of neuro-oncology
2025

Diffuse astrocytoma presenting with parkinsonism and gliomatosis-like infiltration.

The New Zealand medical journal
2025

Clinical and molecular characteristics and prognostic factors of diffuse astrocytoma, IDH-wildtype, not elsewhere classified.

Journal of neuro-oncology
2025

Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas.

Frontiers in oncology
2026

Pediatric Diffuse Low-Grade Gliomas: Radiology, Symptoms, Treatment, and Molecular Pathways.

Neuroimaging clinics of North America
2025

Pediatric-Type Diffuse Low Grade Glioma.

Advances in cancer research
2025

A single-institution study of the natural history of fibroblast growth factor receptor-altered gliomas.

Neuro-oncology practice
2025

MOLECULAR MARKERS IN PREDICTING THE OUTCOME OF DIFFUSE GLIOMA GRADE 4 TREATMENT.

Experimental oncology
2025

Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.

Frontiers in oncology
2025

Coexistence of IDH1 Mutation and KIAA1549::BRAF Fusion in a Diffuse Glioma: A Case Report With Clinical, Radiological, and Pathological Correlation.

Neuropathology : official journal of the Japanese Society of Neuropathology
2025

Novel Application of Ion Mobility Mass Spectrometry Reveals Complex Ganglioside Landscape in Diffuse Astrocytoma Peritumoral Regions.

International journal of molecular sciences
2025

Pediatric-Type Diffuse Low-Grade Gliomas: A Subgroup Defined by Peculiar Molecular Features and Distinct Prognostic Outcomes.

Cureus
2025

Molecular alterations in IDH-mutant astrocytoma: A multi-institutional retrospective study.

Neuro-oncology advances
2025

Pediatric-Type Diffuse Low-Grade Gliomas with MYB Alterations: Neuroimaging of the Diffuse Astrocytomas, MYB- or MYBL1-Altered.

AJNR. American journal of neuroradiology
2025

Patterns of response following gamma knife radiosurgery for tectal plate gliomas.

Journal of neuro-oncology
2025

Diffuse astrocytoma, AYA-type, frequently MAPK-altered: report of 45 patients.

Acta neuropathologica
2025

High-Grade Glioma With Parotid Metastasis: A Case Report of Long-Term Treatment and Follow-Up.

Cureus
2025

Multi-center real-world data-driven web calculator for predicting outcomes in IDH-mutant gliomas: Integrating molecular subtypes and treatment modalities.

Neuro-oncology advances
2025

Do clinical outcomes in individuals with malignant gliomas differ between sexes?

Brain &amp; spine
2024

Free-hand Frameless Pinless Electromagnetic-Navigation (AXIEM™)-Guided Brain Lesion Biopsies: An Institution Based Experience from a Low-Middle-Income Country.

Pakistan journal of medical sciences
2024

Gliomatosis Cerebri Manifested as Parkinsonism Syndrome: A Case Report.

Case reports in neurological medicine
2024

Q-Ball high-resolution fiber tractography: Optimizing corticospinal tract delineation near gliomas and its role in the prediction of postoperative motor deficits- A proof of concept study.

Brain &amp; spine
2025

A Case of Anterior Cingulotomy for Intractable Pain Caused Thalamic Glioma.

Journal of Korean Neurosurgical Society
2025

Phase I Clinical Study of a Multi-Kinase Inhibitor TG02 Capsule for the Treatment of Recurrent High-Grade Gliomas with Failed Temozolomide Treatment in Chinese Patients.

Chemotherapy
2024

High-Grade Thalamic Glioma: Case Report with Literature Review.

Medicina (Kaunas, Lithuania)
2024

Recent updates in pediatric diffuse glioma classification: insights and conclusions from the WHO 5th edition.

Journal of medicine and life
2024

MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes.

Acta neuropathologica
2024

Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review).

Molecular medicine reports
2024

Optimal treatment strategy for low-grade spinal cord astrocytoma: a retrospective, multicenter analysis by the Neurospinal Society of Japan.

Journal of neurosurgery. Spine
2024

Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma.

Dermatology and therapy
2024

The Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors.

Cancers
2024

Filling the gap: brief neuropsychological assessment protocol for glioma patients undergoing awake surgeries.

Frontiers in psychology
2024

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations.

Acta neuropathologica
2024

Radiation-Induced Low-Grade Glioma following Radiotherapy for Squamous Cell Carcinoma of the Scalp: Case Report and Literature Review.

Case reports in surgery
2024

Deep Residual Learning-Based Classification with Identification of Incorrect Predictions and Quantification of Cellularity and Nuclear Morphological Features in Digital Pathological Images of Common Astrocytic Tumors.

Cancers
2024

FANCM Gene Variants in a Male Diagnosed with Sertoli Cell-Only Syndrome and Diffuse Astrocytoma.

Genes
2024

Pediatric-type diffuse low-grade gliomas.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2024

Case report: A 53-year-old woman with synchronous WHO classification II and IV gliomas.

Frontiers in oncology
2024

Development of Predicting Nomograms for Diffuse Astrocytoma and Anaplastic Astrocytoma: A Study Based on the Surveillance, Epidemiology, and End Results Database.

World neurosurgery
2024

Whole Spinal Cord FDG Uptake at PET/CT Caused by H3K27-Altered Diffuse Midline Glioma in an Adult Patient.

Clinical nuclear medicine
2024

Bilateral tinnitus associated with a diffuse astrocytoma of Heschl's gyrus: a case report and review of literature.

Journal of surgical case reports
2024

T2-FLAIR Mismatch: An Imaging Biomarker for Children's MYB/MYBL1-Altered Diffuse Astrocytoma or Angiocentric Glioma.

AJNR. American journal of neuroradiology
2024

Metastases and Primary Brain Tumors Affecting the Fornix of the Brain.

Cureus
2024

Neurophysiotherapy in Grade II Diffuse Astrocytoma: A Case Report.

Cureus
2024

Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma.

Neuropathology : official journal of the Japanese Society of Neuropathology
2024

Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas.

Journal of neuro-oncology
2023

Long-term epilepsy associated-tumors (LEATs): what is new?

Arquivos de neuro-psiquiatria
2023

Astrocytoma Mimicking Herpetic Meningoencephalitis: The Role of Non-Invasive Multimodal Monitoring in Neurointensivism.

Neurology international
2024

Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.

Epilepsy research
2024

The T2-FLAIR mismatch sign in oncologic neuroradiology: History, current use, emerging data, and future directions.

The neuroradiology journal
2023

Review on neuroimaging in pediatric-type diffuse low-grade gliomas.

Frontiers in pediatrics
2023

Role of endoscopic third ventriculostomy in patients undergoing resection of pulvinar area lesions: Preliminary clinical results.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2024

Proton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors.

European radiology
2024

Cytopathology of glioneuronal and neuronal tumours with histological correlations.

Cytopathology : official journal of the British Society for Clinical Cytology
2023

Treatments associated with all-cause mortality among children with primary brain and central nervous system tumors: a retrospective cohort study from the SEER database.

Translational pediatrics
2023

[Tyrosine kinase receptor gene fusion: A series of four cases of infantile-type hemispheric glioma].

Annales de pathologie
2023

Unreported branching pattern of the triplicated anterior cerebral artery associated with multiple bilateral variants of the superior cerebellar artery detected by computed tomography angiography and 3D modeling.

Surgical and radiologic anatomy : SRA
2023

Diagnostic algorithm for pathological evaluation of gliomas in a resource-constrained setting.

Journal of cancer research and therapeutics
2023

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing.

Frontiers in neurology
2023

Awake Craniotomy for Resection of Diffuse Astrocytoma During Pregnancy: A Case Report.

Cureus
2023

Case Report: Brainstem angiocentric glioma presenting in a toddler child-diagnostic and therapeutic challenges.

Pathology oncology research : POR
2023

Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis.

Anticancer research
2023

Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors.

Frontiers in neuroscience
2023

DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

Overexpression of Podoplanin Predicts Poor Prognosis in Patients With Glioma.

Applied immunohistochemistry &amp; molecular morphology : AIMM
2023

Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report.

Frontiers in oncology
2023

2021 updates to the World Health Organization classification of adult-type and pediatric-type diffuse gliomas: a clinical practice review.

Chinese clinical oncology
2022

[Report of Multidisciplinary Treatment for Sisters with Li-Fraumeni Syndrome].

Gan to kagaku ryoho. Cancer &amp; chemotherapy
2022

Paediatric-type diffuse low-grade gliomas: a clinically and biologically distinct group of tumours with a favourable outcome.

Pathologica
2022

Malignant transformation in low-grade astrocytoma for long-term monitoring.

Journal of cancer research and therapeutics
2022

An MRI-based joint model of radiomics and spatial distribution differentiates autoimmune encephalitis from low-grade diffuse astrocytoma.

Frontiers in neurology
2022

Resilience in Lower Grade Glioma Patients.

Cancers
2022

T2-Fluid-Attenuated Inversion Recovery (FLAIR) Mismatch as a Novel Specific MRI Marker for Adult Low-Grade Glioma (LGG): A Case Report.

Cureus
2022

Surgical techniques and function outcome for cingulate gyrus glioma, how we do it.

Frontiers in oncology
2022

Expression of CD133 Cancer Stem Cell Marker in IDH-Mutant and IDH-wildtype (Isocitrate Dehydrogenase) Astrocytoma.

Asian Pacific journal of cancer prevention : APJCP
2022

The Mean ApoC1 Serum Level in Postoperative Samples from Neurosurgical Patients Is Lower than in Preoperative Samples and during Chemotherapy.

Biology
2023

Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases.

The neuroradiology journal
2022

True anaplastic oligoastrocytoma with dual genotype: illustrative case.

Journal of neurosurgery. Case lessons
2022

5-Aminolevulinic Acid-A Biomarker for Worse Prognosis in IDH-Wildtype II Tumors? Evolution of a Fluorescence-Positive Diffuse Astrocytoma: A Case Report.

Journal of neurological surgery reports
2022

MR Imaging Characteristics and ADC Histogram Metrics for Differentiating Molecular Subgroups of Pediatric Low-Grade Gliomas.

AJNR. American journal of neuroradiology
2022

Alpha2beta1 Integrin Polymorphism in Diffuse Astrocytoma Patients.

Frontiers in oncology
2022

Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient.

Antioxidants (Basel, Switzerland)
2022

Risk Factors Associated with Malignant Transformation of Astrocytoma: Competing Risk Regression Analysis.

Asian journal of neurosurgery
2022

The genomic landscape of dysembryoplastic neuroepithelial tumours and a comprehensive analysis of recurrent cases.

Neuropathology and applied neurobiology
2022

Atypical NMDA receptor expression in a diffuse astrocytoma, MYB- or MYBL1-altered as a trigger for autoimmune encephalitis.

Acta neuropathologica
2022

The early infiltrative phase of GBM hypothesis: are molecular glioblastomas histological glioblastomas in the making? A preliminary multicenter study.

Journal of neuro-oncology
2022

[Algorithm for the integrated diagnosis of gliomas 2021. Our experience].

Medicina
2022

Loss of dimethylated H3K27 (H3K27me2) expression is not a specific marker of malignant peripheral nerve sheath tumor (MPNST): An immunohistochemical study of 137 cases, with emphasis on MPNST and melanocytic tumors.

Annals of diagnostic pathology
2022

Pediatric-type diffuse low grade gliomas: Histomolecular profile and practical approach to their integrated diagnosis according to the WHO CNS5 classification.

Indian journal of pathology &amp; microbiology
2022

Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital.

Chinese neurosurgical journal
2022

Combined Treatment With Radiotherapy and Immunotherapy for Isocitrate Dehydrogenase Mutant Brainstem Glioma in Adult: A Case Report.

Brain tumor research and treatment
2022

Assessment of therapeutic outcome and role of reirradiation in patients with radiation-induced glioma.

Radiation oncology (London, England)
2022

Reclassification of Glioblastoma Multiforme According to the 2021 World Health Organization Classification of Central Nervous System Tumors: A Single Institution Report and Practical Significance.

Cureus
2022

Diffuse astrocytoma with mosaic IDH1-R132H-mutant immuno-phenotype and low subclonal allele frequency.

Intractable &amp; rare diseases research
2022

Rare simultaneous occurrence of a ganglioglioma and diffuse astrocytoma with distinct molecular features in a teenager with neurofibromatosis type 1.

BMJ case reports
2022

The 2021 WHO Classification of Tumors of the Central Nervous System: An update on pediatric low-grade gliomas and glioneuronal tumors.

Brain pathology (Zurich, Switzerland)
2022

Malignant Progression of Diffuse Low-grade Gliomas: A Systematic Review and Meta-analysis on Incidence and Related Factors.

Neurologia medico-chirurgica
2022

β-Catenin marks proliferating endothelial cells in glioblastoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2022

A case of ganglioglioma grade 3 with H3 K27M mutation arising in the medial temporal lobe in an elderly patient.

Neuropathology : official journal of the Japanese Society of Neuropathology
2022

The survival outcomes of molecular glioblastoma IDH-wildtype: a multicenter study.

Journal of neuro-oncology
2022

Young adult males have worse survival than females that is largely independent of treatment received for many types of central nervous system tumors: A National Cancer Database analysis.

Cancer
2021

Malignant Progression of an IDH Mutant Brainstem Glioma in Adult.

NMC case report journal
2022

FISH analyses for 1p and 19q status on gliomas: Reporting an 8 years' experience from a tertiary care center in the Middle East.

Annals of diagnostic pathology
2022

Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.

Journal of cancer research and clinical oncology
2022

Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping.

Neurocirugia
2021

Plasma-Derived Extracellular Vesicles Reveal Galectin-3 Binding Protein as Potential Biomarker for Early Detection of Glioma.

Frontiers in oncology
2021

Hypermethylation of the Promoter of miR-338-5p Mediates Aberrant Expression of ETS-1 and Is Correlated With Disease Severity Of Astrocytoma Patients.

Frontiers in oncology
2022

An Updated Comparison Between World Health Organization Grade II Gemistocytic and Diffuse Astrocytoma Survival and Treatment Patterns.

World neurosurgery
2021

Radiologic-pathologic association of tumor-like lesions with inflammation in cerebral white matter: Comparison of two cases with distinct clinical outcomes.

Neuropathology : official journal of the Japanese Society of Neuropathology
2021

THE SAFETY AND EFFICACY OF ROBOT-ASSISTED STEREOTACTIC BIOPSY FOR BRAIN GLIOMA: EARLIEST INSTITUTIONAL EXPERIENCES AND EVALUATION OF LITERATURE.

Acta clinica Croatica
2021

Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma.

EJNMMI physics
2021

Prognostic Factors Associated With Survival in Patients With Diffuse Astrocytoma.

Frontiers in surgery
2022

Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review.

Neuro-oncology
2022

The persistence of seizures after tumor resection negatively affects survival in low-grade glioma patients: a clinical retrospective study.

Journal of neurology
2021

Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death.

Journal of neuropathology and experimental neurology
2021

Atomic Force Microscope Nanoindentation Analysis of Diffuse Astrocytic Tumor Elasticity: Relation with Tumor Histopathology.

Cancers
2021

Diagnosis and Individualized Treatment of Three Primary Malignant Tumors: A Case Report.

Breast cancer (Dove Medical Press)
2021

Molecular Landscape for Malignant Transformation in Diffuse Astrocytoma.

Global medical genetics
2021

Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report.

The Journal of international medical research
2021

Reproducible imaging-based prediction of molecular subtype and risk stratification of gliomas across different experience levels using a structured reporting system.

European radiology
2021

Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma.

Brain tumor pathology
2021

Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas.

Acta neuropathologica communications
2021

Differential expression of stem cell markers in proliferating cells in glioma.

Journal of cancer research and clinical oncology
2021

Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience.

The Journal of international medical research
2021

[Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2021

Molecular biomarkers and integrated pathological diagnosis in the reclassification of gliomas.

Molecular and clinical oncology
2021

Sotos syndrome: a pitfall in the presurgical workup of temporal lobe epilepsy.

Epileptic disorders : international epilepsy journal with videotape
2021

Spatial concordance of DNA methylation classification in diffuse glioma.

Neuro-oncology
2021

Gliomas - An experience based on molecular markers.

Journal of family medicine and primary care
2021

Can permanent cell lines originate from low-grade astrocytomas: overgrowth of "glia-like" cells in pilocytic and fibrillary (diffuse) astrocytoma cultures.

Bratislavske lekarske listy
2021

Diffusion MRI in Evaluation of Pediatric Posterior Fossa Tumors.

Asian Pacific journal of cancer prevention : APJCP
2021

[Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2021

A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy.

Cancers
2021

Residential proximity to pesticide application as a risk factor for childhood central nervous system tumors.

Environmental research
2021

Anaplastic astrocytoma during pregnancy: the importance of an effective multidisciplinary approach.

BMJ case reports
2021

IDH-mutant gliomas with additional class-defining molecular events.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
2021

A Simple Panel of IDH1 and P53 in Differential Diagnosis Between Low-Grade Astrocytoma and Reactive Gliosis.

Clinical pathology (Thousand Oaks, Ventura County, Calif.)
2021

Diffuse Gliomas of the Brainstem and Cerebellum in Adults Show Molecular Heterogeneity.

The American journal of surgical pathology
2021

Illustration of the Added Value of 18F-DOPA PET to Multimodal MRI to Distinguish Low- and High-Grade Gliomas.

Clinical nuclear medicine
2021

T2-FLAIR Mismatch Sign and Response to Radiotherapy in Diffuse Intrinsic Pontine Glioma.

Pediatric neurosurgery
2020

Resolving mystery behind autonomous retrogression of low-grade gliomas: A systematic review.

JPMA. The Journal of the Pakistan Medical Association
2021

High-resolution melting effectively pre-screens for TP53 mutations before direct sequencing in patients with diffuse glioma.

Human cell
2021

Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review.

Journal of neuro-oncology
2020

TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma.

Frontiers in pharmacology
2023

Serum cytokines in astrocytic brain tumors: a prospective study.

British journal of neurosurgery
2021

Diffuse astrocytoma and the diagnostic dilemma of an unusual phenotype: A case report.

Radiology case reports
2020

Evaluation of the melting temperature of TaqMan probes as a genotyping method for IDH1, IDH2, and H3F3A in pediatric astrocytomas.

Boletin medico del Hospital Infantil de Mexico
2023

IDH-wildtype secondary glioblastoma arising in IDH-mutant diffuse astrocytoma: a case report.

British journal of neurosurgery
2021

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II-IV: a multicenter retrospective case series.

Journal of neuro-oncology
2020

[Diffuse Astrocytoma with Malignant Progression after Long-term Temozolomide Monotherapy:A Case Report].

No shinkei geka. Neurological surgery
2020

A Case of Diffuse Astrocytoma with 32-year Survival after Boron Neutron Capture Therapy.

NMC case report journal
2020

Additional genetic alterations in BRAF-mutant gliomas correlate with histologic diagnoses.

Journal of neuro-oncology
2020

A juvenile case of epilepsy-associated, isocitrate dehydrogenase wild-type/histone 3 wild-type diffuse glioma with a rare BRAF A598T mutation.

Neuropathology : official journal of the Japanese Society of Neuropathology
2020

Histopathological Spectrum of Central Nervous System Tumors: an Experience at a Hospital in Nepal.

Journal of Nepal Health Research Council
2020

[Diffuse Leptomeningeal Glioneuronal Tumor with Subarachnoid Hemorrhage:A Case Report].

No shinkei geka. Neurological surgery
2020

Risk Stratification in Low Grade Glioma: A Single Institutional Experience.

Neurology India
2020

ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.

Radiation oncology (London, England)
2020

Surgical treatment of low-grade brain tumors associated with epilepsy.

International review of neurobiology
2020

99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans.

Contrast media &amp; molecular imaging
2020

Pediatric Low-Grade Gliomas.

Cancers
2021

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.

Academic radiology
2020

Neuroimaging Findings in Children with Constitutional Mismatch Repair Deficiency Syndrome.

AJNR. American journal of neuroradiology
2020

Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient.

Radiology case reports
2021

Eslicarbazepine in patients with brain tumor-related epilepsy: a single-center experience.

The International journal of neuroscience
2020

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.

Annals of diagnostic pathology
2020

Textiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report.

Journal of neurological surgery reports
2020

T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor.

European journal of radiology
2020

Prognostic Factors and Nomogram Predicting Survival in Diffuse Astrocytoma.

Journal of neurosciences in rural practice
2020

High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas.

Frontiers in oncology
2020

Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes.

Oncotarget
2021

Association of the FGFR1 mutation with spontaneous hemorrhage in low-grade gliomas in pediatric and young adult patients.

Journal of neurosurgery
2020

Risk stratification in pediatric low-grade glioma and glioneuronal tumor treated with radiation therapy: an integrated clinicopathologic and molecular analysis.

Neuro-oncology
2020

Extent of resection and molecular pathologic subtype are potent prognostic factors of adult WHO grade II glioma.

Scientific reports
2019

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Astrocytic Tumors in Iraqi Patients.

Open access Macedonian journal of medical sciences
2020

Molecular Aberrations Associated with Seizure Control in Diffuse Astrocytic and Oligodendroglial Tumors.

Neurologia medico-chirurgica
2020

Epithelioid glioblastoma presenting as multicentric glioma: A case report and review of the literature.

Surgical neurology international
2020

Seizure freedom from recurrent insular low-grade glioma following laser interstitial thermal therapy.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2019

Spinal rosette-forming glioneuronal tumor: A case report.

Medicine
2019

Natural History of Pediatric Low-Grade Glioma Disease - First Multi-State Model Analysis.

Journal of Cancer
2019

Giant Cell-rich Tanycytic Ependymoma as Intramedullary Spinal Mass.

Neurology India
2019

The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01.

Brain tumor research and treatment
2020

Favorable prognosis in pediatric brainstem low-grade glioma: Report from the German SIOP-LGG 2004 cohort.

International journal of cancer
2020

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Acta neuropathologica
2020

Eliciting Smiles and Laughter During Intraoperative Electric Stimulation of the Cingulum: Surgical Scenario.

World neurosurgery
2019

An autopsy case of widespread brain dissemination of glioblastoma unnoticed by magnetic resonance imaging after treatment with bevacizumab.

Surgical neurology international
2019

Usefulness and safety from stereotactic biopsy in posterior fossa lesions in adult patients.

Cirugia y cirujanos
2020

Clinical relevance of molecular subgrouping of gliomatosis cerebri per 2016 WHO classification: a clinicopathological study of 89 cases.

Brain pathology (Zurich, Switzerland)
2019

Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.

Acta neurochirurgica
2019

Clinical Significance of Molecular Diagnosis of Pilocytic Astrocytoma: A Case Report.

NMC case report journal
2019

Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification.

Journal of pathology and translational medicine
2019

Tumor-associated status epilepticus in patients with glioma: Clinical characteristics and outcomes.

Epilepsy &amp; behavior : E&amp;B
2019

Brain cancer survival in Canada 1996-2008: effects of sociodemographic characteristics.

Current oncology (Toronto, Ont.)

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Comunidades

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Eloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery.
    Surgical neurology international· 2026· PMID 41660341mais citado
  2. A 57-year-old male with diffuse astrocytoma in the lateral ventricle: case report.
    BMC neurology· 2026· PMID 41872835mais citado
  3. Exploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.
    Cancer letters· 2026· PMID 41825848mais citado
  4. Pediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.
    Pediatric radiology· 2026· PMID 41591436mais citado
  5. Pediatric Diffuse Low-Grade Gliomas: Radiology, Symptoms, Treatment, and Molecular Pathways.
    Neuroimaging clinics of North America· 2026· PMID 41274768mais citado
  6. Intrinsic pontine tumors: Pathology of brainstem tumors and exploration of diffuse intrinsic pontine glioma.
    Handb Clin Neurol· 2026· PMID 41896005recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251595(Orphanet)
  2. MONDO:0016686(MONDO)
  3. GARD:5907(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Q55786375(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Astrocitoma difuso
Compêndio · Raras BR

Astrocitoma difuso

ORPHA:251595 · MONDO:0016686
Prevalência
1-9 / 1 000 000
CID-10
D33.2 · Neoplasia benigna do encéfalo, não especificado
CID-11
Ensaios
11 ativos
Início
Adolescent, Adult, Childhood
Prevalência
0.48 (United States)
MedGen
UMLS
C0280785
Repurposing
2 candidatos
carmustineDNA alkylating agent|DNA inhibitor
temozolomideDNA alkylating agent
EuropePMC
Wikidata
Papers 10a
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