Carcinoma papilar ou folicular da glândula tireoide com componente genético que se desenvolve dentro da mesma família. Estudos atuais sugerem que é herdado em um padrão autossômico dominante. Muitas vezes é multifocal e bilateral e geralmente afeta pacientes mais jovens.
Introdução
O que você precisa saber de cara
Carcinoma papilar ou folicular da glândula tireoide com componente genético que se desenvolve dentro da mesma família. Estudos atuais sugerem que é herdado em um padrão autossômico dominante. Muitas vezes é multifocal e bilateral e geralmente afeta pacientes mais jovens.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 8 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 19 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição.
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (
Secreted
Thyroid cancer, non-medullary, 5
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression
Nucleus
Bamforth-Lazarus syndrome
An autosomal recessive disease characterized by congenital hypothyroidism due to thyroid agenesis or thyroid hypoplasia, cleft palate, spiky hair, with or without choanal atresia, and bifid epiglottis.
Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be ph
Endoplasmic reticulum lumenSecretedCell membrane
Thyroid cancer, non-medullary, 2
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151)
Cell membraneGolgi apparatusGolgi apparatus membraneNucleusCytoplasmCytoplasm, perinuclear region
Costello syndrome
A rare condition characterized by prenatally increased growth, postnatal growth deficiency, intellectual disability, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities.
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Cell membraneGolgi apparatus membrane
Leukemia, juvenile myelomonocytic
An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42
Thyroid cancer, non-medullary, 2
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Variantes genéticas (ClinVar)
252 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
37 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Carcinoma papilar ou folicular da tireoide, forma familiar
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
NLRP3 Inflammasome Activation-Induced Acute Papillitis as a Trigger of Acute Pancreatitis - A Novel Mechanism of Microlithiasis-Induced Acute Pancreatitis.
Obstruction of the pancreatic duct by impacted gallstones at the level of the papilla vateri causes acute pancreatitis. How non-obstructing stones such as microlithiasis or sludge cause pancreatitis has not been studied. We aimed to understand the pathomechanism of microlithiasis-induced acute pancreatitis. In human papillary biopsies from patients with microlithiasis-induced acute pancreatitis (n = 4), alcohol-induced acute pancreatitis (n = 5), and control subjects without pancreatobiliary disease (n = 4), the inflammatory infiltrate was quantified. Bone marrow-derived macrophages generated from C57BL/6 mice were treated in vitro with cholesterol monohydrate and calcium bilirubinate crystals, and NLRP3 inflammasome-mediated macrophage activation was quantified. Microlithiasis formation in the gallbladder was induced in mice through lithogenic high fat diet and devazepide. Acute pancreatitis was induced by supramaximal caerulein stimulation. Microlithiasis ejection from the gallbladder was achieved through low-dose caerulein i.p. Injections. Pancreatitis severity was compared between caerulein-induced pancreatitis and caerulein-induced pancreatitis after repetitive microlithiasis ejection. Significantly higher infiltration of CD45-positive leukocytes and increased NLRP3 expression were observed in papillary biopsies from patients with microlithiasis-induced acute pancreatitis compared with patients with alcohol-induced acute pancreatitis and control subjects. In line with this, significantly higher IL-1ß secretion and caspase-1 activation were observed in vitro in bone marrow-derived macrophages stimulated with cholesterol monohydrate and calcium billirubinate crystals. In vivo microlithiasis formation was achieved in all mice with high fat diet and devazepide. Compared to caerulein-induced pancreatitis, in caerulein + microlithiasis pancreatitis, higher LDH, GPT and ALP levels in serum were observed, but without an impact on pancreatitis severity. However, mice papilla mimicked the phenotype of microlithiasis-induced acute pancreatitis in humans. We propose a novel mechanism in which biliary microlithiasis induces a local inflammatory reaction at the papilla (acute papillitis) via NLRP3 inflammasome activation driven by bone marrow-derived macrophages, without causing pancreatic outflow obstruction.
Comparative Evaluation of HMG Family Proteins and miR-106a-5p in Low-Grade Non-Invasive and High-Grade Muscle-Invasive Papillary Urothelial Carcinoma.
Urothelial carcinoma (UC) of the bladder exhibits low- and high-grade papillary forms with distinct prognoses. High mobility group proteins (HMGA1, HMGA2, HMGB1) and miR-106a-5p are involved in tumor progression, but their interplay in UC remains incompletely understood. The aim of this study was to compare the expression of these parameters in low- and high-grade papillary UC. Tissue samples from 80 patients (40 low-grade and 40 high-grade) undergoing transurethral resection or cystectomy were analyzed, with control samples consisting of tumor-adjacent tissues without histopathological alterations obtained from the same patients. HMGA1, HMGA2, and HMGB1 protein expression was assessed immunohistochemically. Gene expression was quantified by real-time PCR, and miR-106a-5p levels were measured by droplet digital PCR. Statistical analysis was conducted using Statistica 13.3, applying one-way ANOVA with Tukey's post hoc test and correlation analysis, with p < 0.05 considered significant. Expression of HMGA1 and HMGB1 was reduced in low-grade papillary urothelial carcinoma compared to control tissues, whereas both proteins were significantly increased in high-grade lesions. HMGA2 expression was minimal in low-grade tumors but partially restored in high-grade tumors. Analysis revealed the highest levels of miR-106a-5p in normal urothelium, slightly decreased in low-grade tumors, and significantly reduced in high-grade cancers. HMG proteins and miR-106a-5p demonstrate distinct expression patterns in low- versus high-grade papillary UC, which correlates with tumor aggressiveness. These molecules may serve as diagnostic and prognostic biomarkers. Their potential as therapeutic targets requires further mechanistic and translational investigation.
Blindness after middle meningeal artery embolization for skull metastasis of follicular thyroid carcinoma with ophthalmic artery variant.
Preoperative embolization for intracranial tumors is widely used to minimize intraoperative blood loss; however, it carries the risk of ischemic or cranial nerve complications, particularly in patients with anatomical variants. A 47-year-old woman with a history of follicular thyroid carcinoma (FTC) was referred after an intracranial mass was detected on magnetic resonance imaging. The lesion was initially suspected to be a meningioma. However, contrast-enhanced computed tomography showed that the tumor was located lateral to the middle meningeal artery (MMA), suggesting an epidural lesion. Angiography confirmed a strong tumor blush from the MMA, and preoperative embolization was performed. During angiography, a branch of the MMA extending toward the orbit was identified; this branch was coil-occluded before Embosphere injection to prevent inadvertent embolization. The patient developed ipsilateral blindness immediately after the procedure. Subsequent internal carotid angiography revealed an anatomical variant in which the ophthalmic artery (OphA) did not originate from the internal carotid artery (ICA). In this context, retinal ischemia was attributed primarily to coil occlusion of the MMA branch supplying the retinal circulation, with possible exacerbation from subsequent Embosphere injection. The tumor was completely resected through craniotomy, and histopathology confirmed metastasis of FTC. At 5 years postoperatively, there was no evidence of intracranial recurrence, although the visual loss was permanent. Skull metastasis of FTC is an uncommon clinical entity. This case highlights a serious complication of preoperative embolization due to a vascular variant in which the OphA was absent from the ICA and the central retinal artery originated from the MMA, leading to irreversible blindness. Thorough angiographic evaluation is essential to identify anatomical variants before embolization. When high-risk anatomy is present, alternative strategies should be considered to minimize the risk of ischemic complications.
TrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells.
Carcinoma (PTC) is the most common malignant tumor derived from thyroid follicular cells and represents the most common pathological type of thyroid malignancy. Cancer metastasis and radiosensitivity are important factors that limit the treatment of PTC. This study aimed to investigate the regulatory effects of transient receptor potential channel C5 (TrpC5) on the proliferation, invasion, migration, and radiosensitivity of PTC. Human papillary thyroid carcinoma cell lines TPC-1 and B-CPAP were transfected with TrpC5 siRNA, pcDNA-TrpC5, or their corresponding negative control. PTC cells were stimulated by radiotherapy. The results showed that TrpC5 silencing weakened the proliferation, invasion, and migration of PTC cells, whereas TrpC5 overexpression promoted these cellular behaviors. Moreover, TrpC5 expression was progressively upregulated in PTC cells following exposure to irradiation (IR). TrpC5 silencing enhanced radiosensitivity of TPC-1 and B-CPAP cells. In addition, TrpC5 silencing enhanced the expression of DNA damage-related proteins p-ATM, p-CHK, and γH2AX in PTC cells under IR treatment. Overall, TrpC5 silencing weakened cell invasion and migration and enhanced the radiosensitivity of PTC cells. These findings suggest that TrpC5 may serve as a potential therapeutic target for PTC and warrant further investigation in vivo.
International Multidisciplinary Consensus Report on Definitions, Diagnostic Criteria, and Management of Fatty Pancreas: A Joint Statement Endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG.
This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing terminology and diagnostic frameworks, the report also synthesizes current knowledge across a wide range of relevant domains. These include the etiology and epidemiology of fatty pancreas, as well as its associations with alcohol consumption, smoking, acute and chronic pancreatitis, pancreatic exocrine insufficiency, type 2 diabetes mellitus, and surgical outcomes. The potential links between fatty pancreas and neoplastic conditions such as intraductal papillary mucinous neoplasms and pancreatic cancer are also addressed, alongside the current understanding of its metabolic implications (beta-cell function and glucose homeostasis) and treatment strategies. Throughout the consensus process, a consistent theme emerged: the limited availability of high-quality, prospective clinical data. Therefore, many of the recommendations in this report are based on expert consensus rather than strong empirical evidence. As such, the statements require rigorous prospective validation before they can be adopted into routine clinical practice. This underscores a critical need for further research, particularly studies aimed at clarifying causal relationships, validating diagnostic tools, and determining the clinical relevance of fatty pancreas across diverse patient populations. This report serves as both a summary of our current understanding and a roadmap for future investigations, aiming to close existing knowledge gaps and guide evidence-based clinical practice in this emerging field.
Publicações recentes
NLRP3 Inflammasome Activation-Induced Acute Papillitis as a Trigger of Acute Pancreatitis - A Novel Mechanism of Microlithiasis-Induced Acute Pancreatitis.
Comparative Evaluation of HMG Family Proteins and miR-106a-5p in Low-Grade Non-Invasive and High-Grade Muscle-Invasive Papillary Urothelial Carcinoma.
Case Report: Diagnosis and treatment strategy for a case of multiple chest wall implantations and neck lymph node metastasis following total areola endoscopic surgery for papillary thyroid carcinoma.
Coexisting Graves' Disease and Papillary Thyroid Carcinoma: The Importance of Nodule Surveillance in Autoimmune Hyperthyroidism.
Familial papillary thyroid cancer; A male case with breast and thyroid cancer and his three sisters with thyroid cancer: A case series and review of the literature.
📚 EuropePMCmostrando 199
Primary Hyperaldosteronism: Epidemiology, Diagnosis, and Clinical Associations.
Epidemiologia (Basel, Switzerland)[Initially palliative, later converted to neoadjuvant therapy in advanced, extensively mediastinal lymphogenous metastatic follicular thyroid carcinoma - a case report].
Deutsche medizinische Wochenschrift (1946)Clinicopathological and sonographic characterization of NTRK-fusion papillary thyroid carcinoma based on preoperative molecular testing: a comparative study with BRAFV600E PTC.
Frontiers in oncologyEpidemiology, risk factor and prognostic factor of young differentiated thyroid carcinoma with distant metastasis: a retrospective cohort study.
American journal of cancer researchRisk of malignancy in PTEN-altered thyroid nodules detected on preoperative FNA molecular testing: a systematic review and meta-analysis.
Human pathologyDeceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications.
Head & neckFine needle aspiration cytology in the diagnosis of thyroid nodules.
La Tunisie medicaleNLRP3 Inflammasome Activation-Induced Acute Papillitis as a Trigger of Acute Pancreatitis - A Novel Mechanism of Microlithiasis-Induced Acute Pancreatitis.
United European gastroenterology journalAn In-Depth Evaluation of CD15 Expression in Thyroid Carcinoma: A Comprehensive Systematic Review.
Cancer reports (Hoboken, N.J.)Comparative Evaluation of HMG Family Proteins and miR-106a-5p in Low-Grade Non-Invasive and High-Grade Muscle-Invasive Papillary Urothelial Carcinoma.
International journal of molecular sciencesFollicular Thyroid Carcinoma Metastasis to the Retromolar Trigone: A Case Report.
CureusPrognostic significance of minimal extrathyroidal extension in differentiated thyroid carcinoma: a retrospective cohort study.
Brazilian journal of otorhinolaryngologyAssociation between Androgenic Hair Patterns and Prostate Cancer Risk in South Indian Men: A Case-control Study from the Cauvery Delta.
The Journal of the Association of Physicians of IndiaCase Report: Diagnosis and treatment strategy for a case of multiple chest wall implantations and neck lymph node metastasis following total areola endoscopic surgery for papillary thyroid carcinoma.
Frontiers in oncologyBisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High-Dose Effects Challenge Regulatory Thresholds.
Journal of applied toxicology : JATThyroglobulin Autoantibodies Do Not Influence the Outcome of Patients With Differentiated Thyroid Carcinoma.
Endocrinology, diabetes & metabolismExploring the molecular mechanisms underlying the inflammation-cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics.
AutoimmunityCoexisting Graves' Disease and Papillary Thyroid Carcinoma: The Importance of Nodule Surveillance in Autoimmune Hyperthyroidism.
CureusFamilial papillary thyroid cancer; A male case with breast and thyroid cancer and his three sisters with thyroid cancer: A case series and review of the literature.
Indian journal of cancerEnhancing patient selection for thyroid thermal ablation: insights from a multidisciplinary team approach.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia GroupHIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung.
ImmunityTWO CASES OF THYROID COLLISION TUMORS WITH DIFFERENT DIFFERENTIATION PATHWAYS.
Experimental oncologyImpact of Co-Mutations and Genetic Variations on Malignancy Risk in RAS-Positive Indeterminate Thyroid Nodules: an Institutional Experience.
Endocrine pathologyBlindness after middle meningeal artery embolization for skull metastasis of follicular thyroid carcinoma with ophthalmic artery variant.
Surgical neurology internationalArtificial intelligence-enabled ultrasound diagnosis and stratification of follicular thyroid neoplasms: a multi-center study.
NPJ digital medicineAge Modifies the Prognostic Impact of Sex in Follicular Thyroid Carcinoma: A SEER Database Analysis.
Annals of surgical oncologyClinical implication of the 2025 ATA risk stratification in follicular thyroid carcinoma: A comparison with the 2015 ATA risk stratification.
Oral oncologyTrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells.
Frontiers in cell and developmental biologyAdvances in immunotherapy for thyroid malignancies: from molecular targets to clinical outcomes.
Frontiers in medicineModified Shenlingbaizhu decoction suppresses colon cancer via enhancing memory-like Tfh differentiation and B cell responses.
Phytomedicine : international journal of phytotherapy and phytopharmacologyRPS6KA1 Remodels Fatty Acid Metabolism and Suppresses Malignant Progression in Colorectal Cancer.
BiomedicinesAnaplastic thyroid carcinoma: Clinicopathologic and immunohistochemical study of 144 cases with special emphasis on the spectrum of histologic features.
Virchows Archiv : an international journal of pathology[A Case of Colorectal Carcinoma with Subserosal Fibrosis in the Absence of Tumor Invasion].
Gan to kagaku ryoho. Cancer & chemotherapySEAP-GETNE consensus on prognostic and predictive molecular biomarkers in thyroid cancer.
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de CitologiaDifferences in the aggressiveness of familial versus sporadic non-medullary thyroid cancer: An unresolved controversy.
Archives of endocrinology and metabolismBerberine induces pyroptosis by promoting the NLRP3/Caspase-1/GSDMD pathway in papillary thyroid carcinoma.
Biochemical and biophysical research communicationsAnalysis of Galectin-3 in Differentiating Non-malignant and Malignant Nodular Thyroid Lesions.
CureusMilk fat globule-EGF factor 8 enhances the proliferation and migration of thyroid carcinoma cells through epithelial-mesenchymal transition and PI3K/AKT signaling pathway.
World journal of surgical oncologyUnveiling a new SORBS2::BRAF fusion in papillary thyroid carcinoma: insights from molecular diagnostics.
Virchows Archiv : an international journal of pathologyMismatch Repair Deficiency in Benign and Atypical Ocular Sebaceous Neoplasms: Implications for Muir-Torre Screening and Classification.
American journal of ophthalmologyUltrasound features of thyroid follicular adenoma and follicular carcinoma: A narrative review.
The Journal of international medical researchRare RET Variants in a Patient With MEN2A and Multiple Follicular-Derived Thyroid Tumors: A Case Report and Review of the Literature.
International journal of surgical pathologyThyroid Cancer in Solid-Organ Transplant Recipients.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationPrevalence of KDM6A deficiency in human cancer: A tissue microarray study on 18,570 cancers from 153 different tumor types.
Virchows Archiv : an international journal of pathologyDNA Methylation-based Risk Stratification and Classification of Pediatric Thyroid Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchThyroid collision tumor and Graves' disease: A case report and review of literature.
World journal of clinical casesRectal follicular thyroid-like carcinoma: A case report and review of literature.
World journal of gastrointestinal oncologyThyroid and breast carcinomas in a patient with Pendred syndrome: a case report and literature review.
Frontiers in oncologySkip metastases in papillary thyroid carcinoma: evidence from a multicenter European retrospective study.
Frontiers in endocrinologyClinical and immunological significance of tertiary lymphoid structure maturation heterogeneity in brain metastases of lung adenocarcinoma.
Journal of translational medicineInternational Multidisciplinary Consensus Report on Definitions, Diagnostic Criteria, and Management of Fatty Pancreas: A Joint Statement Endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG.
United European gastroenterology journalCorrelation between cytology and histology in patients with atypia of undetermined significance thyroid nodules at a tertiary laboratory in the Western Cape province, South Africa.
Journal of the American Society of CytopathologyPlasma cells and plasmacytoid features in thyroid lesions.
Virchows Archiv : an international journal of pathologyAfirma Genomic Sequencing Classifier Performance in Young Patients with Cytologically Indeterminate Thyroid Nodules.
The Journal of clinical endocrinology and metabolismUnmasking malignancy-thyrotoxic hypokalemic periodic paralysis and papillary thyroid carcinoma in a young male with Graves' disease: a case report.
AME case reportsDiagnostic role of Ki-67 expression in distinguishing thyroid follicular carcinoma from follicular adenoma: a systematic review and meta-analysis.
Annals of medicine and surgery (2012)[A case of mixed follicular-papillary-eosinophilic adenocarcinoma of the thyroid gland].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryVarious genetic alterations observed in both benign and malignant oncocytic (Hürthle cell) neoplasms of the thyroid.
CytoJournalSynchronous Presence of Papillary, Medullary, and Anaplastic Thyroid Tumors in a Single Patient: A Rare Case Report.
The American journal of case reportsPrognostic Stratification of Highly Differentiated Thyroid Cancer Based on Molecular Genetic Studies.
Asian Pacific journal of cancer prevention : APJCPIsolated cerebellar metastasis as the initial presentation of follicular thyroid carcinoma: A rare neurosurgical encounter.
Surgical neurology internationalPapillary glioneuronal tumor presenting with recurrent epileptic seizures in a 6-year-old boy: A case report and comprehensive literature review.
Surgical neurology internationalAnalysis of external dose rate attenuation and its related factors in differentiated thyroid carcinoma patients following I-131 therapy.
EJNMMI physicsDual pancreatic carcinomas: clonally related or independent primaries?
NPJ precision oncologyAnaplastic Thyroid Carcinoma With Horner Syndrome and Unusual Metastasis Reveals Masked Papillary Thyroid Carcinoma Following Neoadjuvant Therapy.
AACE endocrinology and diabetes[Differentiated thyroid carcinoma in children and adolescents].
Problemy endokrinologiiPapillary thyroid carcinoma in thyroglossal duct cyst: a Peruvian case series.
Endocrinology, diabetes & metabolism case reportsFamilial Annular Erythema Effectively Responded to Phototherapy: A Case Report of an Extremely Rare Entity and Literature Review.
Case reports in dermatologySingle-cell analysis identifies ATC-like cells driving progression in relapsed follicular thyroid carcinoma.
EndocrinologyNonsurgical Management of Cardiac Papillary Fibroelastoma on the Aortic Valve.
Journal of medical casesCXCL8/SDC1 axis mediates tumor stem cell interactions to drive remote transfer in thyroid cancer.
Journal of pharmaceutical analysisTransurethral thulium laser resection via ureterorenoscope for pediatric low-grade urothelial carcinoma of the bladder: a case report.
BMC surgeryRisk factors and survival analysis of patients with distant metastatic follicular thyroid cancer.
Frontiers in endocrinologyPrimary Thyroid Tuberculosis Masquerading as a Follicular Neoplasm With Tracheal Compression: A Case Report.
CureusTympany in a cow secondary to a follicular-compact thyroid carcinoma with metastases.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncEvaluating the predictive value of optical coherence tomography angiography metrics and central corneal thickness among glaucoma suspect patients: a comparative cross-sectional study.
Medical hypothesis, discovery & innovation ophthalmology journalApproach to the patient: Oncocytic thyroid cancer.
The Journal of clinical endocrinology and metabolismUnilateral Multifocal Follicular Thyroid Carcinoma with Vascular Invasion and Primary Hepatic Metastasis in a Dog: First Documented Case.
Veterinary sciencesNovel Homozygous Variants in CIDEC and WRN in a Young Female with Lipodystrophy and Thyroid Cancer.
International journal of molecular sciencesReview of Genomic Drivers of Thyroid Cancer and Their Clinical Implications.
Genes[Ultrastructural and morphometric features of follicular thyroid adenomas].
Arkhiv patologiiSomatic Mutational Landscape in Follicular Thyroid Cancer: Insights from AACR GENIE Data.
Journal of personalized medicineIdentification of Rare Noncoding Variants in Familial Nonmedullary Thyroid Carcinoma.
Thyroid : official journal of the American Thyroid AssociationAnalysis of clinical and histopathological features in concurrent papillary and medullary thyroid carcinoma.
Discover oncologySTAT1-TCTN3 axis drives papillary thyroid carcinoma progression by accelerating the cell cycle and promoting tumor cell migration and invasion.
International journal of biological macromoleculesPDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review).
Molecular medicine reportsProteoAutoNet: high-throughput co-eluted protein analysis with robotics and machine learning.
Nature communicationsCollision thyroid tumors: a case report of coexisting papillary and follicular carcinoma.
Journal of surgical case reportsMeningeal metastatic tumor with bone destruction from follicular thyroid carcinoma: a case report and literature review.
Frontiers in surgeryPredictive US findings for differentiating between malignant and benign thyroid nodules: Doppler and microvascular imaging according to the TI-RADS and pathologic subtypes of malignancy.
Ultrasonography (Seoul, Korea)Prognostic Factors and Competing Risk Analysis in Early-Stage Follicular Thyroid Carcinoma: A Population-Based Study.
The American surgeonPediatric follicular thyroid carcinoma: a clinicopathologic study treated at a single institution during a 30-year period.
EndocrineUltrasound radiomics-based machine learning models for risk stratification of follicular thyroid tumors.
Frontiers in oncologyTherapeutic targeting of the FSP1-ACSL4 axis reverses cisplatin resistance via ferroptosis induction in drug-tolerant papillary thyroid carcinoma.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryIntegrating TBSRTC subcategorization and BRAF V600E testing for precision management of Bethesda III thyroid nodules: a WHO 5th edition-based study highlighting subtype-specific diagnostic disparities.
Frontiers in oncologyCase Report: Malignant PEComa of the thyroid combined with follicular carcinoma: a rare case of collision tumor.
Frontiers in oncologyMetastatic thyroid-like follicular renal cell carcinoma with EWSR1::PATZ1 fusion: A case report and review of the literature.
Human pathologyRare malignant transformation of struma ovarii into follicular thyroid carcinoma: A case report.
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia[Follicular Thyroid Carcinoma Detected by Cervical Palpation in a Young Patient-A Case Report].
Gan to kagaku ryoho. Cancer & chemotherapyMucoepidermoid carcinoma of the thyroid gland: genetic insights and a rare clinical presentation.
Virchows Archiv : an international journal of pathologyRecurrent Orbital Metastases in Follicular Variant Papillary Thyroid Carcinoma After Recombinant Human Thyrotropin.
JCEM case reportsSolitary Flat Bone Metastasis of Follicular Thyroid Carcinoma: Complete Molecular and Partial Structural Response After 2 131I Therapies.
Journal of nuclear medicine technologyBilaterality in papillary thyroid carcinoma: long-term outcomes and predictive factors.
Thyroid research[Non-Invasive Follicular Neoplasm with Papillary-Like Nuclear Features in Struma Ovarii].
Acta medica portuguesaDiagnostic value of combined detection of serological biomarkers in thyroid carcinoma.
American journal of cancer researchGlucose-transporter 1 (GLUT1) as a prognostic biomarker: evidence from 14,966 human tumors across 134 cancer types.
BMC cancerAssociation of iodine nutritional status with thyroid nodules and papillary thyroid carcinoma in women from an iodine-sufficient region in Brazil: A cross-sectional center study.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)RNA in situ hybridization based TRIM63 characterization in tubulocystic renal cell carcinoma.
Human pathologyMetastasis of lung adenocarcinoma to follicular thyroid carcinoma combined with papillary thyroid carcinoma in the contralateral lobe: A case report.
Oncology lettersHistologic Patterns and Germline Genetic Testing Outcomes in Presumed Sporadic Bilateral Renal Masses.
Urology practice[ 18 F]PSMA Tracer and 131 I Avid Retroperitoneal Thyroid Tissue in a Patient with Synchronous Thyroid and Prostate Carcinomas: First Case Report and Literature Review.
World journal of nuclear medicineReview of Familial Adenomatous Polyposis: Current Understanding and Clinical Management.
JCO oncology practiceBeyond 1100delC: distinct CHEK2 variants and unique cancer phenotypes in Northeast Brazil.
Familial cancerThe Occurrence of Gene Fusions in Thyroid Lesions and the Relation With Chronic Lymphocytic Thyroiditis.
Pathology internationalSelected updates in thyroid, parathyroid, and adrenal gland pathology.
Human pathologyGenetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings.
Frontiers in medicineUnmasking familial follicular cell-derived thyroid neoplasms associated with syndromes: DICER1 and PTEN-hamartoma tumor syndromes.
Virchows Archiv : an international journal of pathologyEvaluation of the diagnostic utility of galectin-1 and TROP-2 in thyroid tumors: A retrospective analysis.
Qatar medical journalFrequency Distribution of Neoplastic and Non-neoplastic Thyroid Lesions in Relation to Patient Age and Gender.
CureusRisk of Second Primary Cancer Among Patients with Thyroid Carcinoma in Finland: A Nationwide Population-Based Study.
Clinical epidemiologyMisdiagnosed follicular adenoma with 11 year postoperative liver and lung metastases a case report and literature review.
Discover oncologyVery low thyroglobulin level and rare metastatic location in radio-iodine refractory DTC should raise suspicion for initial misdiagnosis.
Nuclear medicine review. Central & Eastern EuropeThe Bethesda System Revisited: Malignancy Risk Estimation and NIFTP Impact in a Large Cohort From Northern India.
Diagnostic cytopathologyINDIVIDUAL THYROID DOSE ESTIMATES FOR THE GENOMIC STUDY OF FOLLICULAR CARCINOMAS AND ADENOMAS IN PARTICIPANTS OF THE CHORNOBYL TISSUE BANK.
Problemy radiatsiinoi medytsyny ta radiobiolohiiAssociation of Familial Adenomatous Polyposis With Classic Papillary Thyroid Carcinoma and Acromegaly: A Case Report.
AACE endocrinology and diabetesProsthetic joint replacement for femoral bone metastases and pathological fracture: A retrospective case series study of cases within the past 10 years.
MedicineMolecular Differences in Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (IEFVPTC) and Infiltrative Follicular Variant of Papillary Thyroid Carcinoma (IFVPTC): The Role of Extracellular Matrix.
BiomoleculesDedifferentiation and Redifferentiation of Follicular-Cell-Derived Thyroid Carcinoma: Mechanisms and Therapeutic Implications.
BiomedicinesCoexistence of familial dysalbuminemic hyperthyroixinemia and papillary thyroid carcinoma: a rare case report and diagnostic challenge.
Therapeutic advances in endocrinology and metabolismHyperkeratosis Lenticularis Perstans (Flegel's Disease) in a Middle-Aged Man: A Rare Keratinization Disorder.
CureusAn integrated bioinformatics and multi-omics investigation of the sirtuin family to identify their prognostic importance in human cancers.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and MedicineThe prognostic significance of lymph node metastasis-related genes in pancreatic adenocarcinoma is associated with immune cell infiltration and ferroptosis.
Medicine[Clinicopathological and genetic features of thyroid tumors with PTEN mutations].
Zhonghua yi xue za zhi[Clinical and pathological characteristics analysis of 40 reoperation cases after thermal ablation treatment for thyroid carcinoma].
Zhonghua yi xue za zhi[Correlation between obesity and ultrasonic malignant features of papillary thyroid carcinoma].
Zhonghua yi xue za zhi[Follicular thyroid carcinoma combined with anaplastic thyroid carcinoma: a report of two cases].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryMolecular Pathology of Thyroid Follicular Epithelial Cell-Derived Neoplasia: An Update.
Archives of pathology & laboratory medicineThree Different Etiologies in Three Similar Looking Intrathyroidal Nodules: Role of Tc-99m SestaMIBI Scintigraphy and SPECT-CT in a Patient With Primary Hyperparathyroidism.
Clinical nuclear medicineCranial vault metastasis revealing follicular thyroid carcinoma.
The Pan African medical journalDiagnostic Significance of Trophoblast Cell Surface Antigen-2 Expression in Benign and Malignant Thyroid Lesions.
CureusBrain Metastases From Differentiated Thyroid Cancer in the Era of Targeted Therapies: A Multi-Center Retrospective Cohort.
Head & neckA Study of Survival Outcomes in Well-Differentiated Thyroid Carcinomas at a Tertiary Health Center in South India.
Indian journal of surgical oncologyEncapsulated neoplasms of the thyroid gland.
Virchows Archiv : an international journal of pathologyPrognostic impact of RAS mutation on papillary thyroid carcinoma: a systematic review and meta-analysis.
Thyroid researchPrognostic factors evaluated in differentiated thyroid carcinomas.
Endocrine connectionsReinterpretation of the clinical and biological behaviors of papillary thyroid carcinoma subtypes within the 2022 WHO classification: a cross-sectional study of 768 cases.
World journal of surgical oncologyOvarian metastasis in a young woman with follicular thyroid carcinoma: A differential diagnosis with struma ovarii.
Endocrinologia, diabetes y nutricionRecent developments in eosinophilic renal neoplasms: what's new, true and important?
HistopathologyRecurrence factors in familial papillary thyroid carcinoma.
Minerva endocrinologyMultimodal spectrum of approach in poorly differentiated thyroid carcinoma (an updated analysis).
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieThyroid cancer pathology: Insights from a developing region.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskundeRecurrence after ablation of Bethesda IV thyroid nodule: report of two cases.
Gland surgeryDiagnostic Challenges, Prognostic Assessment, and Treatment Strategies in High-Grade Differentiated Thyroid Carcinoma.
Endocrinology and metabolism (Seoul, Korea)Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma.
CancersHigh Local and Systemic Expression of Pentraxin-3 in Anaplastic Thyroid Cancer.
International journal of molecular sciences[A case of severe liver injury associated with erythropoietic protoporphyria].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology[Integration of Molecular, Genetic, and Surgical Evidence Into the Indication Criteria for Preventive Thyroid Surgery].
Zentralblatt fur ChirurgiePREVALENCE OF THE BRAF V600E MUTATION AMONG INDIGENOUS INDIVIDUALS WITH PAPILLARY THYROID CARCINOMA RESIDING IN A RADIATION-EXPOSED AREA.
Georgian medical newsTransoral endoscopic thyroidectomy using the vestibular approach in pediatric patients: 5-year experience in a single center in Vietnam.
World journal of pediatric surgeryComparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas.
Communications biologyDiagnostic value of molecular testing for evaluating thyroid nodules greater than 4 centimeters.
American journal of surgeryA tertiary-center experience of patients with simultaneous medullary and papillary thyroid carcinomas.
Hormones (Athens, Greece)Prognostic Significance of Preoperative Inflammatory Markers in Thyroid Follicular Neoplasms: Focus on Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios.
Journal of clinical practice and researchPositive predictive value of the Afirma gene sequencing classifier for evaluation of the indeterminate thyroid nodule: An institutional experience.
American journal of surgeryPreoperative diagnostic accuracy of thyroid follicular carcinoma using fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography and blood data.
Annals of nuclear medicineMethionyl-tRNA synthetase 1 expression, the possibility as a diagnostic and prognostic factor in papillary thyroid cancer.
BMC cancerRegion-wise pattern of demographic, clinicopathological and treatment profile of thyroid cancers from 96 hospital-based cancer registries in India.
EcancermedicalscienceIndependent predictors and ultrasound-based risk stratification for follicular thyroid tumors: a multicenter retrospective study.
World journal of surgical oncologyLithium Therapy-Associated Thyroid Alterations Mimicking Thyroid Malignancy: A Diagnostic Pitfall.
International journal of surgical pathologyCYTOLOGICAL EXAMINATION OF THYROID NEOPLASMS IN INDIGENOUS RESIDENTS LIVING IN THE FORMER SEMIPALATINSK NUCLEAR TEST SITE AREA.
Georgian medical newsUltrasound-guided needle localization in trans-mammary endoscopic thyroidectomy: a case report.
Journal of medical case reportsA retrospective Case-Control study investigating the association of XPC Lys939Gln (rs2228001), XPD Lys751Gln (rs13181), and TP53 Arg72Pro (rs1042522) with papillary thyroid carcinoma susceptibility in the Bangladeshi population.
Molecular biology reportsTwo Cohorts, One Network: Consensus Master Regulators Orchestrating Papillary Thyroid Carcinoma.
International journal of molecular sciencesPrevalence and clinical significance of CBP deficiency and disturbed CBP expression in human cancer.
Experimental and molecular pathologyPotential Utility of Micronucleus and Binucleus Frequencies in Malignancy Prediction in Thyroid Nodules.
Head & neckPost-thyroidectomy ultrasonography versus thyroglobulin as a surveillance tool for locoregional recurrence in patients with differentiated thyroid carcinoma: A single centre 10-year study.
Frontiers in endocrinologyMultimodal Prediction Model Integrating Clinical Parameters, Peritumoral and Habitat-Based Radiomics for Preoperative Differentiation of Follicular Thyroid Carcinoma from Adenoma: A Two-Center Study.
Academic radiologyHereditary syndromes and RCC: what radiologists need to know.
Abdominal radiology (New York)Medullary Thyroid Carcinoma Without Calcitonin: A Case Linking Ultimobranchial Bodies to Tumor Evolution.
Pathophysiology : the official journal of the International Society for PathophysiologyFamilial Papillary Thyroid Carcinoma-4 Members from a Single Family.
Indian journal of surgical oncologyHashimoto's thyroiditis in an Egyptian cohort: clinical, functional, and ultrasonographic features with insights into nodule risk.
Frontiers in endocrinologyMulticenter Evaluation of Thyroid Nodule Size: Implications for FNA Diagnostic Accuracy and Malignancy Risk.
Medical archives (Sarajevo, Bosnia and Herzegovina)Rare Presentation of Mandibular Metastases from Differentiated Thyroid Carcinoma: A Case Series - Experience from a Single Tertiary Care Hospital.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaPapillary thyroid carcinoma measuring 1.0 cm or less: an epidemiological and clinicopathological study.
Frontiers in oncologyFollicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology.
Endocrine pathologyAge, not tumor size, modifies the association between extrathyroidal extension and long-term outcomes in patients with follicular cell-derived thyroid carcinoma.
Annals of Saudi medicinePapillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy.
The Journal of pathologyClinical differences and surgery in follicular vs oncocytic thyroid carcinomas.
Endocrine-related cancerSingle status shows age dependent bidirectional effects in differentiated thyroid cancer.
Scientific reportsCorrelation of Bethesda Categories in Thyroid Lesions With Histopathology: A Single Tertiary Care Center Experience.
CureusInvestigation of Factors Affecting Histopathological Upgrade in Breast Papillary Lesions: A Single-Center Study.
Breast care (Basel, Switzerland)Efficacy and Safety of Thermal Ablation for Follicular Thyroid Neoplasms: A Multicenter Retrospective Study with >5-Year Follow-up.
Academic radiologyMediterranean Diet Adherence and One-Year Metabolic Changes in Patients with Papillary Thyroid Cancer: An Observational Study.
NutrientsDiagnostic Models for Predicting Follicular Thyroid Carcinomas Using Circulating Plasma MicroRNAs.
CancersSphingolipid Metabolism in the Pathogenesis of Hashimoto's Thyroiditis.
International journal of molecular sciencesNatural Compounds Targeting MAPK, PI3K/Akt, and JAK/STAT Signaling in Papillary Thyroid Cancer.
International journal of molecular sciencesPsammoma bodies in a benign thyroid gland: A case report and brief review of the literature.
Medicine internationalCalcitonin and procalcitonin: Revisiting the overlooked role of C cells.
Metabolism: clinical and experimentalTuberous sclerosis complex-associated renal cell carcinoma, an underappreciated form of familial renal cancer, is characterized by activation of the TFEB/TFE3 pathway.
Human molecular geneticsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- NLRP3 Inflammasome Activation-Induced Acute Papillitis as a Trigger of Acute Pancreatitis - A Novel Mechanism of Microlithiasis-Induced Acute Pancreatitis.
- Comparative Evaluation of HMG Family Proteins and miR-106a-5p in Low-Grade Non-Invasive and High-Grade Muscle-Invasive Papillary Urothelial Carcinoma.
- Blindness after middle meningeal artery embolization for skull metastasis of follicular thyroid carcinoma with ophthalmic artery variant.
- TrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells.
- International Multidisciplinary Consensus Report on Definitions, Diagnostic Criteria, and Management of Fatty Pancreas: A Joint Statement Endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG.
- Case Report: Diagnosis and treatment strategy for a case of multiple chest wall implantations and neck lymph node metastasis following total areola endoscopic surgery for papillary thyroid carcinoma.
- Coexisting Graves' Disease and Papillary Thyroid Carcinoma: The Importance of Nodule Surveillance in Autoimmune Hyperthyroidism.
- Familial papillary thyroid cancer; A male case with breast and thyroid cancer and his three sisters with thyroid cancer: A case series and review of the literature.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:319487(Orphanet)
- MONDO:0017895(MONDO)
- GARD:8488(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q56014051(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
