A vacina para a encefalite transmitida por carrapatos é uma vacina utilizada para prevenir a encefalite transmitida por carrapatos. Essa doença é mais comum na Europa Central e Oriental, e no norte da Ásia. mais de 87% das pessoas vacinadas desenvolvem imunidade. No entanto, ela não é eficaz se recebida logo após a picada de um carrapato infectado. A via de injeção é intramuscular.
Introdução
O que você precisa saber de cara
Doença infeciosa rara caracterizada por meningoencefalite grave não purulenta causada pelo vírus da doença Borna 1 (BoDV-1). Os doentes apresentam febre, dor de cabeça, mal-estar e fadiga, seguidos após alguns dias por náusea, confusão e desorientação, e lentidão psicomotora. Ataxia, afasia, dispneia, espasmos mioclónicos multifocais e paraplegia foram descritos. A condição é frequentemente fatal após progredir para letargia, deterioração dos reflexos do tronco cerebral e coma. O exame do líquido cefalorraquidiano revela pleocitose linfo-monocítica moderada e presença de RNA BoDV-1.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Encefalite Borna virus
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Development of a strand-specific RT-qPCR assay for detecting and quantifying Borna disease virus RNAs in infected cells.
Borna disease virus 1 (BoDV-1) is a nonsegmented negative-strand RNA virus (NSV) that persists in the central nervous system of a broad range of mammalian species. Considering the recent reports linking BoDV-1 to fatal encephalitis in humans, a deeper understanding of its viral life cycle is required. Similar to other NSVs, BoDV-1 produces three types of viral RNAs in infected cells: genome, antigenome, and mRNA. Although a conventional reverse transcription quantitative real-time PCR (RT-qPCR) assay is used to detect viral RNAs, this assay cannot distinguish between RNA species because of primer-independent cDNA synthesis during the reverse transcription (RT) reaction. In this study, we developed a strand-specific RT-qPCR (ssRT-qPCR) assay, in which an RT-primer fused with a non-viral tag sequence at the 5'-end is used in the RT reaction. This assay successfully detected and quantified three types of BoDV-1 RNAs distinctively. Furthermore, using this assay, we measured the intracellular kinetics of the BoDV-1 RNA species, revealing that BoDV-1 may control transcription, but not replication, to establish and maintain persistent infection. Overall, this novel ssRT-qPCR assay is a powerful tool for understanding the life cycle of BoDV-1.
Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective.
Human Borna disease virus 1 (BoDV-1) encephalitis is characterized by rapid clinical progression, an absence of a causal therapy and an extremely high case fatality rate. Here, we discuss prevention options through a hypothetical vaccine focusing on epidemiological features.
Structural insights into the dynamic mechanism of bornavirus polymerase.
Borna disease virus 1 (BoDV-1), an emerging zoonotic pathogen from the Bornaviridae family, is neurotropic and can infect a variety of mammalian hosts, including humans. Linked to severe encephalitis and high mortality, BoDV-1 currently lacks licensed treatments or vaccines. The BoDV-1 polymerase complex, comprising the large (L) and phosphoprotein (P) subunits, is crucial for viral replication and transcription, making it a promising target for antiviral intervention. Here, we present the cryoelectron microscopy structure of the apo BoDV-1 L-P complex, revealing a unique "mitten-shaped" architecture. The structure characterizes key domains involved in RNA synthesis, including RNA-dependent RNA polymerase, polyribonucleotidyltransferase, and an inactive methyltransferase domain. While no RNA or NTPs were visible, we observed distinct conformational states, showing large-scale rearrangements of the P tetramer and L domains, as well as remodeling of the RNA template, nucleoside triphosphates, and nascent RNA entrances and/or exits, upon introducing RNA and NTPs. These findings highlight the dynamic structural changes probably associated with polymerase activity and advance the understanding of the BoDV-1 polymerase mechanisms, offering a basis for developing targeted antiviral strategies against this deadly pathogen.
Mapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts.
Borna disease virus 1 (BoDV-1) has long been recognized as a cause of fatal encephalitis in animals and was only recently identified as a zoonotic pathogen causing a similar disease in humans. This study provides the first comprehensive comparative analysis of BoDV-1-induced neuropathology in human and animal end hosts, including horses, sheep, and alpacas. Using immunohistochemical analyses, we investigated the topographical distribution of BoDV-1 and inflammatory responses in the central nervous system across 19 cases. Key findings reveal distinct differences and overlaps between humans and animals. While humans exhibited heterogeneous patterns especially of the lymphocyte infiltration, animals displayed more species-specific inflammation and viral spread patterns. In horses, the hippocampus and basal ganglia were consistently affected, whereas sheep showed predominant involvement of the frontal cortex and stria olfactoria. Alpacas demonstrated a less uniform distribution but highlighted the brainstem and basal ganglia as critical sites. Intriguingly, across all species, a negative association was observed between lymphocyte infiltration and the number of BoDV-1-infected cells. These findings enhance our understanding of BoDV-1 pathogenesis and is a first step of cross-species comparison in unraveling disease mechanisms in BoDV-1 infection. Further research is warranted to elucidate the implications of these findings for therapeutic strategies and to explore the entry and dissemination routes of BoDV-1 in different hosts.
Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species.
Although laboratory methods have advanced, the cause of many encephalitides is still unknown. Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time-consuming and costly. These analyses require appropriate tissue preparations and are more difficult to perform on formalin-fixed, paraffin-embedded (FFPE) tissues. Anti-double-stranded RNA (dsRNA) antibodies could potentially identify virus infections independently of the viral genome and can be applied to FFPE material. This study examined the applicability of monoclonal anti-dsRNA antibodies by immunohistochemistry to confirm encephalitides caused by different RNA viruses and comparing the findings with those obtained using monoclonal and polyclonal virus-specific antibodies. The viruses studied included negative-sense (Borna disease virus 1, BoDV-1; canine distemper virus, CDV; Rift Valley fever virus, RVFV) and positive-sense single stranded RNA viruses (severe acute respiratory disease syndrome coronavirus 2, SARS-CoV-2; tick-borne encephalitis virus, TBEV; Theiler's murine encephalomyelitis virus, TMEV). Interestingly, dsRNA was detected in both infected and non-infected animals and inconsistently co-localized to BoDV-1, TBEV, and TMEV antigen. Strict co-localization was lacking in CDV, SARS-CoV-2 and RVFV. Despite the co-localization of dsRNA with virus antigen for some RNA viruses, anti-dsRNA antibodies were unreliable as markers for unknown virus infections. Future studies should explore the upstream components of the immune response, including the interferon signaling cascade to assess their potential as effective virus-sensing tool.
Publicações recentes
Developing a universal multi-epitope protein vaccine candidate for enhanced borna virus pandemic preparedness.
Epigenetic Targeting for Controlling Persistent Neurotropic Infections Caused by Borna Virus and HIV.
Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing.
Research Note: Development of a reverse transcriptase recombinase-aided amplification method for detection of Parrot Borna Virus 4.
Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection.
📚 EuropePMC4 artigos no totalmostrando 86
Development of a strand-specific RT-qPCR assay for detecting and quantifying Borna disease virus RNAs in infected cells.
Journal of virological methodsSpillover infections by rustrela virus, borna disease virus 1 and tick-borne encephalitis virus revealed by retrospective screening of mammalian encephalitis of unknown origin.
BMC veterinary researchIs vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective.
PLoS pathogensFirst therapeutic drug monitoring of experimental favipiravir in Borna disease virus 1 (BoDV-1) encephalitis patients reveals significant gaps in antiviral treatment: a pilot investigation.
European journal of medical researchStructural insights into the dynamic mechanism of bornavirus polymerase.
Proceedings of the National Academy of Sciences of the United States of AmericaMapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts.
PLoS pathogensScreening for Borna disease virus 1 (BoDV-1) in Austria: Absence of human cases in a retrospective case-finding study.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesHighly specific serological diagnosis of Borna disease virus 1 (BoDV-1) and variegated squirrel bornavirus 1 (VSBV-1) encephalitis by novel antibody isotype assay with multiple viral antigens.
Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyExperimental infection of shrews (Crocidura russula) with Borna disease virus 1: Insights into viral spread and shedding.
PNAS nexusBorna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells.
Npj virusesEvaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species.
Frontiers in veterinary scienceNeuropathology, pathomechanism, and transmission in zoonotic Borna disease virus 1 infection: a systematic review.
The Lancet. Infectious diseasesDeveloping a universal multi-epitope protein vaccine candidate for enhanced borna virus pandemic preparedness.
Frontiers in immunologyAnalysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder.
Frontiers in psychologyBorna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Journal of medical virologyA single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activity.
Microbiology and immunologyLethal Borna disease virus 1 infections of humans and animals - in-depth molecular epidemiology and phylogeography.
Nature communicationsClinical analysis of Bornavirus Encephalitis cases demonstrates a small time window for Etiological Diagnostics and treatment attempts, a large case series from Germany 1996-2022.
InfectionComparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection.
Emerging microbes & infectionsDetection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis.
InfectionLong-term Elevation of Complement Factors in Cerebrospinal Fluid of Patients With Borna Disease Virus 1 Encephalitis.
The Journal of infectious diseasesSuppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System.
International journal of molecular sciencesOne Health in action: Investigation of the first detected local cluster of fatal borna disease virus 1 (BoDV-1) encephalitis, Germany 2022.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology18fluorodeoxyglucose PET/CT as possible early diagnostic tool preceding MRI changes in Borna disease virus 1 encephalitis.
Lancet (London, England)Case report: Fatal Borna virus encephalitis manifesting with basal brain and brainstem symptoms.
Frontiers in neurologyHAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection.
Antiviral researchEvaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis.
Journal of translational medicineSevere Neurologic Disease in a Horse Caused by Tick-Borne Encephalitis Virus, Austria, 2021.
VirusesNo evidence of an association of multiple sclerosis (MS) with Borna disease virus 1 (BoDV-1) infections in patients within an endemic region: a retrospective pilot study.
InfectionAlzheimer's disease as a viral disease: Revisiting the infectious hypothesis.
Ageing research reviewsDetection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study.
InfectionThe regulation of persistent Borna disease virus infection by RNA silencing factors in human cells.
Biochemical and biophysical research communicationsRibavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset.
Case reports in psychiatryStructural and biophysical characterization of the Borna disease virus 1 phosphoprotein.
Acta crystallographica. Section F, Structural biology communicationsFirst detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications.
InfectionMagnetic resonance imaging of human variegated squirrel bornavirus 1 (VSBV-1) encephalitis reveals diagnostic pattern indistinguishable from Borna disease virus 1 (BoDV-1) encephalitis but typical for bornaviruses.
Emerging microbes & infectionsRisk factors for Borna disease virus 1 encephalitis in Germany - a case-control study.
Emerging microbes & infectionsCerebrospinal fluid in Borna disease virus 1 (BoDV-1) encephalitis.
Journal of the neurological sciencesIFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study.
VirusesHuman Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany.
VirusesVaccination against Borna Disease: Overview, Vaccine Virus Characterization and Investigation of Live and Inactivated Vaccines.
VirusesReverse Genetics and Artificial Replication Systems of Borna Disease Virus 1.
VirusesDevelopment of a nonhuman primate model for mammalian bornavirus infection.
PNAS nexusNonarboviral Equine Encephalitides.
The Veterinary clinics of North America. Equine practiceHuman Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease.
Emerging microbes & infectionsHealthcare-associated exposure to Borna disease virus 1 (BoDV-1).
Journal of occupational medicine and toxicology (London, England)Pathogen Screening for Possible Causes of Meningitis/Encephalitis in Wild Carnivores From Saxony-Anhalt.
Frontiers in veterinary science[Erratum to: Bornavirus encephalitis as a differential diagnosis to seronegative autoimmune encephalitis].
Der NervenarztMolecular epidemiology of human Borna disease virus 1 infection revisited.
Emerging microbes & infectionsAntibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections.
Cell reports. MedicinemiR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy.
The Journal of general virology[Bornavirus encephalitis as a differential diagnosis to seronegative autoimmune encephalitis].
Der NervenarztHuman Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany.
Emerging microbes & infectionsTick-Borne Encephalitis Virus (TBEV) Infection in Two Horses.
VirusesFatal encephalitis and Borna Disease Virus-1 seropositivity in two kidney-transplant patients living in the same nonendemic area.
Transplant infectious disease : an official journal of the Transplantation SocietyInvestigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany - a case report.
BMC infectious diseasesICTV Virus Taxonomy Profile: Bornaviridae.
The Journal of general virologyActive Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020.
Emerging infectious diseasesA theoretical and generalized approach for the assessment of the sample-specific limit of detection for clinical metagenomics.
Computational and structural biotechnology journalNew World camelids are sentinels for the presence of Borna disease virus.
Transboundary and emerging diseasesFirst isolation, in-vivo and genomic characterization of zoonotic variegated squirrel Bornavirus 1 (VSBV-1) isolates.
Emerging microbes & infectionsThe Challenge of Assessing Mild Neuroinflammation in Severe Mental Disorders.
Frontiers in psychiatryBornavirus Encephalitis Shows a Characteristic Magnetic Resonance Phenotype in Humans.
Annals of neurologyMeningoencephalomyelitis of Unknown Origin in Cats: A Case Series Describing Clinical and Pathological Findings.
Frontiers in veterinary scienceAre human Borna disease virus 1 infections zoonotic and fatal? - Authors' reply.
The Lancet. Infectious diseasesAre human Borna disease virus 1 infections zoonotic and fatal?
The Lancet. Infectious diseasesObesity induced by Borna disease virus in rats: key roles of hypothalamic fast-acting neurotransmitters and inflammatory infiltrates.
Brain structure & functionBorna disease outbreak with high mortality in an alpaca herd in a previously unreported endemic area in Germany.
Transboundary and emerging diseasesAntiviral treatment perspective against Borna disease virus 1 infection in major depression: a double-blind placebo-controlled randomized clinical trial.
BMC pharmacology & toxicologyNo evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses.
Virology journalZoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation.
The Lancet. Infectious diseasesRelaunching human bornavirus research from encephalitis cases with unclear cause.
The Lancet. Infectious diseasesLow prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany.
Scientific reportsViral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?
VirusesA Small Interfering RNA Cocktail Targeting the Nucleoprotein and Large Protein Genes Suppresses Borna Disease Virus Infection.
Frontiers in microbiologyThe neuropathology of fatal encephalomyelitis in human Borna virus infection.
Acta neuropathologicaIntranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity.
International journal of molecular sciencesFatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients.
The New England journal of medicineFatal Encephalitis Associated with Borna Disease Virus 1.
The New England journal of medicineAssessing the Diversity of Rodent-Borne Viruses: Exploring of High-Throughput Sequencing and Classical Amplification/Sequencing Approaches.
Advances in virus researchInfections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease.
Emerging microbes & infectionsPathological findings in the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides), with special emphasis on infectious and zoonotic agents in Northern Germany.
PloS oneScreening red foxes (Vulpes vulpes) for possible viral causes of encephalitis.
Virology journalThe pathogenesis of bornaviral diseases in mammals.
Animal health research reviewsTransolfactory neuroinvasion by viruses threatens the human brain.
Acta virologicaViral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
BioinformationAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Encefalite Borna virus.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Encefalite Borna virus
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Ainda não achamos doenças com sintomas parecidos o suficiente.
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Development of a strand-specific RT-qPCR assay for detecting and quantifying Borna disease virus RNAs in infected cells.
- Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective.
- Structural insights into the dynamic mechanism of bornavirus polymerase.Proceedings of the National Academy of Sciences of the United States of America· 2025· PMID 40996804mais citado
- Mapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts.
- Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species.
- Developing a universal multi-epitope protein vaccine candidate for enhanced borna virus pandemic preparedness.
- Epigenetic Targeting for Controlling Persistent Neurotropic Infections Caused by Borna Virus and HIV.
- Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing.
- Research Note: Development of a reverse transcriptase recombinase-aided amplification method for detection of Parrot Borna Virus 4.
- Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:637051(Orphanet)
- MONDO:0957421(MONDO)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
