Fechamento prematuro do canal arterial

Study of Thoracic Ultrasound As a Response to the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants

NCT06627374

RECRUTANDO

Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels

NCT04508036

DESCONHECIDO

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

NCT03701074

DESCONHECIDO

Timing of Surgical PDA Ligation and Neonatal Outcomes

NCT04126512

CONCLUÍDO

IV Acetaminophen and Patent Ductus Arteriosus

NCT03008876

CONCLUÍDO

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0 papers (10 anos)

#1

Enteral feeding during cyclooxygenase inhibitor treatment for patent ductus arteriosus: A systematic review.

Pediatrics international : official journal of the Japan Pediatric Society2026

This study evaluated the effect of modifying enteral feeding during cyclooxygenase inhibitor (COXI) treatment on patent ductus arteriosus (PDA) in preterm infants. We searched MEDLINE, EMBASE, CENTRAL, CINAHL, and ICHUUSHI databases for randomized and nonrandomized controlled trials, checked the references lists and major clinical trials. Non-human and non-English studies were excluded. Evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation. Preterm infants born before 37 weeks of gestation are treated with COXIs for PDA, including indomethacin and ibuprofen. The primary outcomes were the composite outcome of necrotizing enterocolitis (NEC) or gastrointestinal perforation and its components (NEC and gastrointestinal perforation). Two randomized controlled trials (n = 303) and one retrospective cohort study (n = 261) were included (total: n = 564). No significant differences were observed in the composite gastrointestinal outcome (risk ratio [RR]: 1.10, 95% confidence interval [CI]: 0.51-2.37; 1 study, 177 infants, very low certainty of evidence [CoE]), NEC (RR: 1.01, 95% CI: 0.47-2.15; 2 studies, 300 infants, very low CoE), or gastrointestinal perforation (RR: 1.94, 95% CI: 0.25-14.81; 2 studies, 300 infants, very low CoE) between discontinuation and continuation of enteral feeding. Discontinuation of enteral feeding resulted in a significantly lower rate of surgical closure for PDA compared to continuation (RR: 0.56, 95% CI: 0.37-0.86; 1 study, 177 infants, low CoE). Neither discontinuation nor continuation of enteral feeding significantly affected the composite gastrointestinal outcome and its components (NEC and gastrointestinal perforation).

#2

Patent ductus arteriosus: emerging trial evidence firmly supports conservative management in preterm infants.

Current opinion in pediatrics2026 Apr 01

To summarize recent evidence from randomized clinical trials (RCT) and meta-analysis of patent ductus arteriosus (PDA) closure therapies versus conservative/expectant management on key outcomes such as bronchopulmonary dysplasia (BPD) or death in very preterm (<32 weeks' gestation) infants. Of 10 completed RCTs in the past decade of medical therapies before 2 weeks of age to close a PDA, none demonstrated benefit in reducing moderate-severe BPD/death by 36 weeks postmenstrual age as compared to placebo treatment. When combined, the meta-analysis of the 10 RCTs showed an elevated risk of BPD/death [relative risk (RR): 1.10, 95% confidence interval (CI), 1.01-1.19) and higher risk of death by 36 weeks postmenstrual age or discharge (RR: 1.25; 95% CI, 1.01-1.56). A 2025 Cochrane meta-analysis also found a similar concerning trend of increased mortality following early medical treatment for PDA. Despite their recent popularity, there are no published trials demonstrating safety or efficacy of transcatheter PDA closure. We now have ample evidence for all clinicians to finally acknowledge that conservative PDA management is the correct path forward. Clinical experimentation is no longer acceptable, and expectant PDA management must be adopted as the current standard if we are to adhere to our foundational principle, 'first, do no harm'.

#3

Premature foramen ovale restriction/closure in pregnancy: echocardiographic features and overlap with aortic coarctation.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2026 Dec

Evaluation of the foramen ovale (FO) is essential for understanding right heart predominance in the fetal circulation during the third trimester. Rather than considering the FO as a simple orifice, it should be assessed as a complex anatomical and functional system. Premature FO restriction or closure represents a clinically relevant but diagnostically challenging condition in fetal echocardiography. We conducted a monocentric retrospective study including 600 uncomplicated pregnancies between 22 and 38 weeks of gestation that underwent fetal echocardiography at the Cardiology Service of ASP Reggio Calabria between January and December 2023. The FO was assessed by evaluating septum primum morphology and mobility, ostium secundum configuration, and interatrial shunt direction and magnitude on color Doppler, together with indirect hemodynamic markers. All examinations were conducted by a single operator. All pregnancies resulted in term deliveries with normal neonatal outcomes, and postnatal follow-up lasted 6-9 months. Restrictive or premature closure of the FO was identified in 9 fetuses (incidence 1:66 pregnancies), with FO restrictiveness observed in seven cases and premature closure in two cases. Reduced interatrial shunting was defined as a limited or absent right-to-left flow across the FO on color Doppler, associated with impaired septum primum mobility and/or altered FO geometry. The most consistent indirect echocardiographic sign was right atrial dilation (100% of cases), followed by right ventricular and pulmonary artery predominance with a widely patent ductus arteriosus. In some fetuses, the FO appeared morphologically wide but functionally restrictive. All cases showed favorable early postnatal outcomes. This study evaluates the incidence of FO restriction or premature closure in physiologically normal pregnancies during the third trimester and reviews echocardiographic features useful for its identification.

#4

Fetal Intervention for Giant Chorangioma with Prenatal Ductus Arteriosus Closure: A Case Report.

Fetal diagnosis and therapy2026 Mar 05

Introduction We present a case of spontaneous premature ductus arteriosus (DA) closure following modified interstitial laser ablation (ILA) of a giant chorangioma (GC) in a fetus with evidence of hydrops. Case presentation A 26-week ultrasound revealed a 10-cm GC in the posteriorly located placenta with signs of fetal hydrops, polyhydramnios, and elevated middle cerebral artery peak systolic velocity (MCA PSV) of 1.9 MoM. Preoperative fetal echocardiogram showed elevated combined cardiac output (753 ml/kg/min) without structural abnormalities. Modified ILA targeting the branches of the feeder artery with an extended-pulse technique (30 seconds at 40 Watts) followed by intrauterine fetal transfusion were performed without complications. On post-operative day (POD) 1, new onset of ductus venosus flow reversal was noted, which was attributed to post-procedural hemodynamics. Fetal echocardiography on POD 5 suggested constriction of DA; follow-up confirmed complete DA closure and secondary right heart dysfunction. The pregnancy was managed expectantly with at least weekly echocardiograms. Digoxin and hyperoxygenation for fetal heart failure did not change DA caliber. Acetaminophen and fluoxetine were discontinued without improvement. After an uncomplicated term cesarean delivery (indication: breech), the female neonate was discharged home on day of life 3. Currently, the child is 6 months old and healthy. Conclusion Modified ILA for GC followed by expectant management of associated DA closure yielded a term delivery with a favorable outcome.

#5

Favorable Procedural Outcomes in Lower Versus Higher Weight Premature Infants Undergoing Transcatheter Patent Ductus Arteriosus Closure.

Journal of the Society for Cardiovascular Angiography & Interventions2026 Feb

Timing of device closure of patent ductus arteriosus (PDA) in preterm infants has been a topic of debate. Limited data exist comparing procedural outcomes based on infant weight at the time of the procedure. This study aimed to compare procedural outcomes and adverse events between premature infants weighing <2 kg and those weighing 2 to 5 kg undergoing PDA device closure. We performed a retrospective review of premature infants (<37 weeks gestational age) who underwent transcatheter PDA closure at 2 institutions between 2013 and 2022. Patients were divided into 2 groups: group 1 (<2 kg) and group 2 (2-5 kg). Demographic characteristics, procedural characteristics, success rates, and adverse events were analyzed. Procedural success was defined as successful device placement with no more than small residual shunt and no device embolization within 24 hours. A total of 177 patients were included: 81 in group 1 (<2 kg) and 96 in group 2 (2-5 kg). Procedure success was significantly higher in group 1 than in group 2 (94% vs 83%, P = .031). Group 1 also had shorter median procedure time (50 vs 67 minutes, P = .002) and fluoroscopy time (6.4 vs 11.4 minutes, P < .0001). Adverse events occurred in 11.9% of patients, with a lower rate in group 1, but was not statistically significant (8.6% vs 14.6%, P = .22). No procedure-related mortality occurred. Procedural outcomes of transcatheter PDA closure in premature infants are more favorable among smaller infants with higher success rates and fewer adverse events. Lower weight alone should not delay transcatheter PDA closure in preterm infants with hemodynamically significant PDA.

Publicações recentes

Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic-Pharmacodynamic Analysis.

Clin Pharmacokinet2025 Nov

The Timing and Factor of Ductus Arteriosus Closure in Infants with Down Syndrome Born at Term and Late-Preterm.

Pediatr Cardiol2026 Mar

Systemic Inflammatory Indices as New Biomarkers for Hemodynamically Significant Ductus Arteriosus.

Arq Bras Cardiol2024 Nov

Premature Closure of the Ductus Arteriosus and Veno-Arterial Extracorporeal Membrane Oxygenation in Critically Ill Neonates: A 10-Year Single-Center Retrospective Study.

Pediatr Cardiol2025 Dec

Echocardiographic findings and pregnancy outcomes for fetuses with complete closure of the ductus arteriosus.

J Clin Ultrasound2024 Jul-Aug

Ver todas no PubMed

📚 EuropePMC2 artigos no totalmostrando 200

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Premature foramen ovale restriction/closure in pregnancy: echocardiographic features and overlap with aortic coarctation.

Fetal diagnosis and therapy

Fetal Intervention for Giant Chorangioma with Prenatal Ductus Arteriosus Closure: A Case Report.

Journal of the Society for Cardiovascular Angiography & Interventions

Favorable Procedural Outcomes in Lower Versus Higher Weight Premature Infants Undergoing Transcatheter Patent Ductus Arteriosus Closure.

Transient isolated right ventricular hypertrophy: A benign phenotype in neonates: Case series and review of the literature.

Scottish medical journal

An Unusual Case of Acquired Dilated Cardiomyopathy Due to Long-Standing Patent Ductus Arteriosus.

Pediatrics international : official journal of the Japan Pediatric Society

Enteral feeding during cyclooxygenase inhibitor treatment for patent ductus arteriosus: A systematic review.

Health technology assessment (Winchester, England)

Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial).

Journal of perinatology : official journal of the California Perinatal Association

Prolonged patent ductus arteriosus exposure and risk for late acute kidney injury in extremely preterm infants.

Late Aortic Obstruction Post Patent Ductus Arteriosus Closure Managed with Renata Minima Stent.

Frontiers in cardiovascular medicine

Risk factors for hemodynamically significant patent ductus arteriosus and ibuprofen treatment failure in premature twins: a retrospective case-control study.

Current opinion in pediatrics

Patent ductus arteriosus: emerging trial evidence firmly supports conservative management in preterm infants.

Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month.

Patterns of Segmental Strain of the Left Ventricle in Extremely Premature Infants.

Pediatric reports

Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.

Expanding the literature on Cantú syndrome: recognising early clinical and phenotypic clues.

BMJ case reports

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Efficacy and safety of ibuprofen for the treatment of patent ductus arteriosus in preterm infants of different postnatal ages].

A B-Type Natriuretic Peptide-Based Machine Learning Model for Early Hemodynamic Symptomatic Patent Ductus Arteriosus Prediction.

Pulmonary artery sling with complete tracheal rings in an extremely low-weight premature infant: a case report.

Pediatrics and neonatology

In-hospital and neurodevelopmental outcomes of treatment strategies for patent ductus arteriosus in preterm infants: A retrospective cohort study.

Transcatheter Closure of the Ductus Arteriosus in a Premature Neonate: A Team Effort.

Clinics in perinatology

The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial.

Scientific reports

The journal of obstetrics and gynaecology research

Prolonged Pregnancy Following Long-Term Celecoxib Use in a Case of Uterine Adenomyosis: A Case Report.

Machine learning-based tool to assess risk of hemodynamically significant PDA in extremely premature infants.

Pediatric research

Does Phototherapy Affect Ductus Arteriosus Closure in Preterm Infants ≤32 Weeks of Gestation, and Can We Influence This Through Chest Shielding? Review of the Literature and a Meta-Analysis.

Biomedicines

Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation.

Translational pediatrics

Impact of the Time to Initiation of Indomethacin or Ibuprofen on Patent Ductus Arteriosus Closure Rates.

Paediatric drugs

Journal of the Society for Cardiovascular Angiography & Interventions

Venous-Only Approach for Transcatheter Patent Ductus Arteriosus Closure in Infants: Is It Time for Change?

Journal of perinatology : official journal of the California Perinatal Association

Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation.

Frontiers in cardiovascular medicine

Case Report: Simultaneous covered stenting for aortic coarctation and significant PDA in low and very low birth weight preterm infants: technical insights from two cases.

CJC pediatric and congenital heart disease

A Discourse on Percutaneous Closure of the Patent Ductus Arteriosus in Premature Neonates: Controversy, Remedy, or Paradox of Choice?

Clinical pharmacokinetics

Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic-Pharmacodynamic Analysis.

Evaluating the efficacy and safety of milrinone for prevention of post-patent ductus arteriosus closure syndrome (the MIDAS trial) in extremely preterm infants: a multicentre, double-masked, randomised, placebo-controlled trial.

BMJ open

Current vascular pharmacology

Ductus Arteriosus Variability Linked to Maternal Drug Exposure: Assessment of the USFDA Adverse Event Reporting System using Disproportionality Analysis.

Feasibility and Safety of Percutaneous Device Closure of Patent Ductus Arteriosus in Preterm Neonates: Experience From a Single Center in Northern India.

Indian pediatrics

Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia.

Biomedicines

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Pharmacologic Management of Patent Ductus Arteriosus in the Neonatal Intensive Care Unit: A Retrospective Study.

The First Percutaneous Closures of Patent Ductus Arteriosus in Premature Neonates in Serbia: A Case Report Series.

Reports (MDPI)

Current treatment options in cardiovascular medicine

Patent Ductus Arteriosus in Extremely Preterm Infants: Update on Current Diagnostic and Treatment Options.

Outcomes of extremely preterm infants with bronchopulmonary dysplasia: a retrospective cohort study.

Scientific reports

Does early-targeted risk-based management of a patent ductus arteriosus improve outcomes in preterm infants? Insights from an observational study.

BMJ paediatrics open

A rare vascular complication in a preterm neonate: iliac artery injury following patent ductus arteriosus device closure.

Children (Basel, Switzerland)

Association Between Patent Ductus Arteriosus and the Development of Treatment-Requiring Retinopathy of Prematurity in Preterm Infants: A Single-Center Cohort Study.

Piccolo Device for Treating Patent Ductus Arteriosus Beyond Premature Newborn Patients, a Novel Experience in South America: A Retrospective Study.

Health science reports

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.

MicroRNA Expression Profiles in Very Preterm Infants with Patent Ductus Arteriosus: A Pilot Study.

Effect of Transcatheter Closure of the Ductus Arteriosus on Right Ventricular Function in Preterm Neonates.

In-hospital outcomes of early versus late transcatheter closure of patent ductus arteriosus in preterm infants.

Updates in interventional cardiology in children with cardiac disease.

Paediatric respiratory reviews

Current approaches to the patent ductus arteriosus: Implications for pulmonary morbidities.

Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants.

JAMA network open

Anthropometric measurements of infants in a risk-based patent ductus arteriosus treatment program.

Journal of cardiothoracic surgery

Association between negative T waves in lead V1 and delayed patent ductus arteriosus closure in preterm neonates.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Venous Access Alone Versus Arterial and Venous Access for Patent Arterial Duct Device Closure in Childhood.

Mean Platelet Volume to Platelet Distribution Width Ratio: The Most Effective Platelet Parameter in the Closer of Ductus Arteriosus.

Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants.

Combination therapy for patent ductus arteriosus in preterm infants: Narrative review.

Case reports in perinatal medicine

Persistent pulmonary hypertension of the newborn infant (PPHN) due to premature closure of the ductus arteriosus (DA).

Patent Ductus Arteriosus in Preterm Infants.

Pediatrics

Changes During Reopening in Premature Constriction or Closure of the Ductus Arteriosus: A Report of Two Cases.

The Timing and Factor of Ductus Arteriosus Closure in Infants with Down Syndrome Born at Term and Late-Preterm.

Heterogeneity in treatment response for patent ductus arteriosus: a meta-analysis.

Journal of clinical pharmacology

A Retrospective Analysis of PK and Response of Oral Ibuprofen in the Treatment of a Patent Ductus Arteriosus in Extremely Low Gestational Age Neonates.

Assessment of the relationship between serum magnesium levels, patent ductus arteriosus, and other neonatal morbidities: a retrospective observational study.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Development and Validation of a Novel Deep Learning Model to Predict Pharmacologic Closure of Patent Ductus Arteriosus in Premature Infants.

Impact of PDA Closure Methodology on Peri-procedural Opioid Utilization in Preterm Neonates, a Cross-Sectional Review in a Tertiary Pediatric Healthcare System.

IEEE International Conference on Soft Robotics. IEEE International Conference on Soft Robotics

Toward "S"-Shaped 3D-Printed Soft Robotic Guidewires for Pediatric Patent Ductus Arteriosus Endovascular Interventions.

High altitude medicine & biology

The Course of Ductus Arteriosus from the Neonatal Period to Childhood in a Moderate Altitude Region.

Journal of clinical medicine

The Effect on Extubation of Early vs. Late Definitive Closure of the Patent Ductus Arteriosus in Premature Infants: A Target Trial Emulation Using Electronic Health Records.

Largest Single-Center Experience Using the Micro Vascular Plug (MVP) for Transcatheter Closure of Premature Patent Ductus Arteriosus.

Patent ductus arteriosus rupture during percutaneous device closure: a case report.

Patent Ductus Arteriosus, Hydrocortisone, and Outcome among Infants Born Extremely Preterm: Secondary Analysis of the Hydrocortisone Trial.

Journal of perinatology : official journal of the California Perinatal Association

Management of the patent ductus arteriosus among infants born at 23 to 32 weeks' gestation between 2011 to 2022: a report from in the Children's Hospitals Neonatal Consortium.

Echocardiographic Predictors and Incidence of Left Ventricular Dysfunction Following Transcatheter Patent Ductus Arteriosus Closure in Extremely Premature Infants.

Circulation journal : official journal of the Japanese Circulation Society

High-Humidity Care May Prevent the Development of Patent Ductus Arteriosus in Premature Infants.

Clinical and echocardiographic predictors of medical therapy failure for patent ductus arteriosus closure in preterm infants: Insights from a risk-based treatment approach.

Oral ibuprofen versus placebo in closure of patent ductus arteriosus in preterm neonates, a randomized control trial.

Association of cytochrome P450 CYP2C9 (rs1057910) gene polymorphism and ibuprofen response in preterm neonates diagnosed with patent ductus arteriosus.

TREOCAPA: prophylactic treatment of the ductus arteriosus in preterm infants by acetaminophen-statistical analysis plan for the randomized phase III group sequential trial.

Trials

Risk Factors Associated With the Development of Late Pulmonary Artery Hypertension in Extremely Premature Infants.

Pediatric pulmonology

Low-profile KA microplug set for transarterial occlusion of patent ductus arteriosus in a small dog: First experience in interventional cardiology.

Open veterinary journal

Current cardiology reviews

Safety and Efficacy of Zero Fluoroscopy Patent Ductus Arteriosus Closure in Comparison to the Standardized Fluoroscopy-Guided Procedure: A Systematic Review and Meta-Analysis.

Outcomes of Patent Ductus Arteriosus Closure by Availability of Cardiac Surgeons for Infants Born Preterm.

Patent ductus arteriosus closure in infants weighing less than 1500 g via a tiny microcatheter: a simple technique with zero-contrast exposure.

Zhonghua er ke za zhi = Chinese journal of pediatrics

[Transcatheter closure of patent ductus arteriosus in an extremely low birth weight preterm infant].

Patent Ductus Arteriosus Morphology Changes in Preterm Neonates Undergoing Transcatheter Device Closure.

Andes pediatrica : revista Chilena de pediatria

[Prolonged treatment of patent ductus arteriosus with paracetamol in very low birth weight preterm infants].

Cardiovascular therapeutics

Transcatheter Embolization in Congenital Cardiovascular Malformations-Variable Use of Vascular Plugs.

Fluid restriction for treatment of symptomatic patent ductus arteriosus in preterm infants.

The effect of anti-scatter grids on radiation exposure during transcatheter patent ductus arteriosus closure in premature infants.

Therapeutic Efficacy and Safety of Paracetamol versus Ibuprofen in Patent Ductus Arteriosus in Newborns: A Systematic Review.

Systemic Inflammatory Indices as New Biomarkers for Hemodynamically Significant Ductus Arteriosus.

Effectiveness of repeated pharmacological courses for patent ductus arteriosus in preterm infants.

Late postnatal steroid treatment using oral betamethasone can help to close ductus arteriosus in extremely preterm infants who cannot be weaned from ventilation.

Prophylactic low-dose hydrocortisone in neonates born extremely preterm: current knowledge and future challenges.

Pediatric research

Clinical pharmacokinetics

Population Pharmacokinetics of Intravenous Paracetamol and Its Metabolites in Extreme Preterm Neonates in the Context of Patent Ductus Arteriosus Treatment.

General thoracic and cardiovascular surgery cases

Staged biventricular repair in a premature neonate with critical aortic stenosis, severe mitral regurgitation, and fetal hydrops: a case report.

Airway Management With Congenital Tracheal Stenosis: Surgical and Anesthetic Consideration.

The Laryngoscope

Patent ductus arteriosus closure in small infants weighing less than 1500 g using KA micro plug: steps and tips.

Pediatrics international : official journal of the Japan Pediatric Society

Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review.

The Potential of Ambroxol as a Panacea for Neonatal Diseases: A Scoping Review.

Device Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants.

JACC. Advances

Assessment of Blood Prostaglandin E2 Metabolite Levels among Infants Born Preterm with Patent Ductus Arteriosus: A Prospective Study.

Percutaneous versus surgical closure of patent ductus arteriosus in low-weight premature infants: 10-year experience in a tertiary center.

Anales de pediatria

Impact of a Multidisciplinary Service Line and Program for Transcatheter Device Closure of the Neonatal Ductus Arteriosus.

Perinatal Factors Associated with Successful Pharmacologic Closure of the Patent Ductus Arteriosus in Premature Infants.

Blood pressure increase preceded spontaneous and paracetamol-induced, early ductal closure in very preterm infants.

Transcatheter Patent Ductus Arteriosus Closure in Premature Infants: Comparison of Echocardiogram and Angiogram Measurements.

Journal of the Society for Cardiovascular Angiography & Interventions

Left Pulmonary Artery Occlusion Following Device Closure of Patent Ductus Arteriosus in Premature Infants.

Indian journal of pharmacology

Efficacy of paracetamol in the management of hemodynamically significant patent ductus arteriosus in preterm newborns.

Premature Closure of the Ductus Arteriosus and Veno-Arterial Extracorporeal Membrane Oxygenation in Critically Ill Neonates: A 10-Year Single-Center Retrospective Study.

Selective early medical treatment of the patent ductus arteriosus in extremely low gestational age infants: a pilot randomised controlled trial protocol (SMART-PDA).

BMJ open

Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity.

Pediatrics

Transcatheter and Surgical Ductus Arteriosus Closure in Very Low Birth Weight Infants: 2018-2022.

Pediatrics

Journal of perinatology : official journal of the California Perinatal Association

Procedural closure of the patent ductus arteriosus in preterm infants: a clinical practice guideline.

Journal of perinatology : official journal of the California Perinatal Association

At a crossroads for early medical treatment of persistent patent ductus arteriosus in preterm infants.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Enteral Feedings Do Not Increase the Risk of NEC in ELBW Infants Undergoing Treatment of Patent Ductus Arteriosus With Acetaminophen.

Interventional cardiology clinics

Patent Ductus Arteriosus Occlusion in Premature Infants.

Journal of perinatology : official journal of the California Perinatal Association

Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA.

Use of Paracetamol for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A 5-Year Experience From a Tertiary Hospital in India.

Indian pediatrics

Who Still Gets Ligated? Reasons for Persistence of Surgical Ligation of the Patent Ductus Arteriosus Following Availability of Transcatheter Device Occlusion for Premature Neonates.

Assessing the State of Training in Congenital Interventional Cardiology: A Global Survey of Program Directors.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

Patent ductus arteriosus management in very-low-birth-weight prematurity: a place for an early operation?

The Journal of thoracic and cardiovascular surgery

The American Association for Thoracic Surgery (AATS) 2024 expert consensus document: Management of neonates and infants with Ebstein anomaly.

Journal of clinical ultrasound : JCU

Echocardiographic findings and pregnancy outcomes for fetuses with complete closure of the ductus arteriosus.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Safety and feasibility pilot study of continuous low-dose maternal supplemental oxygen in fetal single ventricle heart disease.

Journal of perinatology : official journal of the California Perinatal Association

A comparison of different dosing regimen of intravenous paracetamol for hemodynamically significant patent ductus arteriosus closure in premature neonates <32 weeks: a prospective observational study.

Cardiorespiratory Instability after Percutaneous Patent Ductus Arteriosus Closure: A Multicenter Cohort Study.

Transcatheter patent ductus arteriosus closure in premature infants requiring high-frequency ventilation.

Proactive Diagnosis and Tailor-Made Treatment of Patent Ductus Arteriosus in Very Preterm Infants with Routine Echocardiography in Japan: A post hoc Analysis of the PLASE Study.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Mobile bedside ductus arteriosus closure in severely premature neonates using only echocardiographic guidance.

Impact of catheterized ductal closure on renal and cerebral oximetry in premature neonates.

Circulation. Cardiovascular interventions

Transcatheter Patent Ductus Arteriosus Closure in Premature Infants: A Multicenter Retrospective Study Comparing Available Devices.

Active versus restrictive ligation strategy for patent ductus arteriosus - A retrospective two-center study of extremely preterm infants born between 22 + 0 and 25 + 6 weeks of gestational age.

Comparative Analysis of Machine Learning Algorithms Evaluating the Single Nucleotide Polymorphisms of Metabolizing Enzymes with Clinical Outcomes Following Intravenous Paracetamol in Preterm Neonates with Patent Ductus Arteriosus.

Current drug metabolism

Journal of clinical ultrasound : JCU

Lung ultrasound score in the decision of patent ductus arteriosus closure in neonates.

Post-ligation cardiac syndrome after surgical versus transcatheter closure of patent ductus arteriosus in low body weight premature infants: a multicenter retrospective cohort study.

Annals of pediatric cardiology

Changes in left ventricular systolic function after transcatheter patent ductus arteriosus closure in premature infants.

Role of patent ductus arteriosus in preterms in long-term outcome.

Percutaneous closure of patent ductus arteriosus versus surgical treatment in low-birth-weight preterms: a systematic review and meta-analysis.

Archives of Iranian medicine

Treatment of Patent Ductus Arteriosus in Premature Infants: Intravenous Paracetamol or Oral Ibuprofen?

The impact of the route of administration on the efficacy and safety of the drug therapy for patent ductus arteriosus in premature infants: a systematic review and meta-analysis.

PeerJ

Journal of perinatology : official journal of the California Perinatal Association

Clinical and echocardiography predictors of response to first-line acetaminophen treatment in preterm infants with hemodynamically significant patent ductus arteriosus.

Journal of perinatology : official journal of the California Perinatal Association

Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants.

Personalized Evidence-Based Management of Patent Ductus Arteriosus in Preterm Infants.

Renal function after ductus arteriosus transcatheter closure with or without angiography in very preterm infants.

Secular Trends in Patent Ductus Arteriosus Management in Infants Born Preterm in the National Institute of Child Health and Human Development Neonatal Research Network.

The Transcatheter Closure of Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants: Technique and Results.

Journal of clinical pharmacology

Pharmacokinetic and Pharmacodynamic Analysis of Acetaminophen and Ibuprofen Dual Therapy for Patent Ductus Arteriosus Closure in Preterm Neonates at Less Than 29 Weeks of Gestation.

Italian journal of pediatrics

Transcatheter closure in preterm infants with patent ductus arteriosus: feasibility, results, hemodynamic monitoring and future prospectives.

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Risk factors and prognosis of hypotension within 72 hours after birth in extremely preterm infants].

Premature closure of the arterial duct presenting with right heart failure of the fetus and ductal aneurysm postnatally.

Closing the Gap: Investigation of Various Approaches in the Management of Patent Ductus Arteriosus.

Medeniyet medical journal

The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns.

Transport and Anaesthesia Consideration for Transcatheter Patent Ductus Arteriosus Closure in Premature Infants.

Interdisciplinary cardiovascular and thoracic surgery

Surgical retrieval of an embolized patent ductus arteriosus closure device in an infant weighing 1050 G.

The effect of Daikenchuto on blood flow of the superior mesenteric artery and portal vein in ELBW: A prospective study.

Trends in Procedural Closure of the Patent Ductus Arteriosus among Infants Born at 22 to 30 Weeks' Gestation.

Journal of perinatology : official journal of the California Perinatal Association

3-year follow-up of a prospective, multicenter study of the Amplatzer Piccolo™ Occluder for transcatheter patent ductus arteriosus closure in children ≥ 700 grams.

Diagnostics (Basel, Switzerland)

Association of the EPAS1 rs7557402 Polymorphism with Hemodynamically Significant Patent Ductus Arteriosus Closure Failure in Premature Newborns under Pharmacological Treatment with Ibuprofen.

Expectant management of patent ductus arteriosus for preterm infants: A meta-analysis of randomized controlled trials.

American heart journal

Turkish archives of pediatrics

Experiences in Patent Ductus Arteriosus Closure of Preterm Infants Transported to Another Center for Surgical Ligation.

Patent Ductus Arteriosus in Preterm Infants and Innovative Cardiac Interventions.

NeoReviews

Paediatrics & child health

Acetaminophen versus indomethacin for patent ductus arteriosus management in premature infants: systematic review and meta-analysis of randomized controlled trials.

Perioperative anesthetic management of premature neonates weighing less than 1500 grams undergoing transcatheter PDA (TC-PDA) closure: An institutional anesthetic experience.

Heliyon

Echocardiographic parameters predicting spontaneous closure of ductus arteriosus in preterm infants.

Effect of fetal lung maturation on the efficacy of acetaminophen for premature infants with patent ductus arteriosus.

Medicine

Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.

Piccolo in transcatheter PDA closure multi-centre study from premature to adolescent children.

Journal of the Society for Cardiovascular Angiography & Interventions

A Global Perspective on PDA Management in the Extremely Premature: Shifting Trend Toward Transcatheter Closure.

Increasing the dose of ibuprofen with postnatal age to close a hemodynamically significant patent ductus arteriosus in very preterm infants.

American journal of perinatology

Patent Ductus Arteriosus Response to Treatment by Course and Associations with Perinatal and Clinical Factors.

Journal of perinatology : official journal of the California Perinatal Association

Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?

Late aortic obstruction due to ductal vasoconstriction on pulmonic end after transcatheter patent ductus arteriosus closure in an extremely low-birth-weight infant.

Expert review of cardiovascular therapy

Congenital heart disease: addressing the need for novel lower-risk percutaneous interventional strategies.

Prophylactic low-dose paracetamol for ductal closure and neurodevelopmental outcome in very preterm infants.

Neonatal acute kidney injury during indomethacin therapy: does it predict ductal closure?

Journal of nephrology

Current problems in cardiology

Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates.

An interpretable machine-learning model for predicting the efficacy of nonsteroidal anti-inflammatory drugs for closing hemodynamically significant patent ductus arteriosus in preterm infants.

Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.

Outcomes of and factors associated with the development of bronchopulmonary dysplasia with pulmonary hypertension in very low birth weight infants: A retrospective study in a medical center.

Pediatrics and neonatology

Trends in neonatal mortality and morbidity in very-low-birth-weight (VLBW) infants over a decade: Singapore national cohort study.

Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.

Platelets and ductus arteriosus closure in neonates.

Seminars in perinatology

Combination pharmacotherapy for patent ductus arteriosus: Rationale and evidence.

Seminars in perinatology

Association of patent ductus arteriosus with fetal factors and endotypes of prematurity.

Seminars in perinatology

Reopening of ductus arteriosus in idiopathic premature constriction or closure of ductus arteriosus: A case series.

Hemoglobin/Red Cell Distribution width Ratio (HRR): A Novel and Promising Red Cell Parameter in Ductal Closure.

International journal of immunopathology and pharmacology

Effectiveness and safety of rectal dexibuprofen versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants with gestational age<34 weeks: A pilot study.

Vascular and pulmonary effects of ibuprofen on neonatal lung development.

Respiratory research

Surgical ligation, not transcatheter closure, associated with a higher severity of bronchopulmonary dysplasia in extremely preterm infant intervened for patent ductus arteriosus.

Pediatric pulmonology

JPMA. The Journal of the Pakistan Medical Association

Outcomes of preterm neonates with patent ductus arteriosus: A retrospective review from a tertiary care hospital.

Cardiovascular changes during phototherapy in newborns.

Physiological research

Pediatrics and neonatology

Predictors of a non-response to prophylactic indomethacin for patent ductus arteriosus in preterm infants.

Frontiers in cardiovascular medicine

Case report: Rescue treatment with add-on selexipag in a preterm infant with suprasystemic pulmonary hypertension, pulmonary capillary hemangiomatosis, and isolated pulmonary vein stenosis.

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.

Texas Heart Institute journal

Outcomes of Surgical Management for Patent Ductus Arteriosus in Infants in Nigeria.

Oral Ibuprofen Is More Effective than Intravenous Ibuprofen for Closure of a Patent Ductus Arteriosus: Can Pharmacokinetic Modeling Help Us to Understand Why?

Outpatient prescription of pulmonary vasodilator therapy to preterm children with bronchopulmonary dysplasia.

Fetal diagnosis and therapy

Bruck Syndrome: Beyond the Obvious.