Introdução
O que você precisa saber de cara
Transtornos do espectro da neuromielite óptica (NMOSD) são um espectro de doenças autoimunes caracterizadas por inflamação aguda do nervo óptico e da medula espinhal (mielite). Os episódios de neurite óptica (ON) e mielite podem ser simultâneos ou sucessivos. Um curso da doença com recidivas é comum, especialmente em pacientes não tratados. Neuromielite óptica (NMO) é uma doença particular dentro do espectro da NMOSD. É caracterizada por neurite óptica e mielite longitudinalmente extensa. Em mais de 80% dos casos de NMO, a causa são autoanticorpos de imunoglobulina G contra a aquaporina 4 (anti-AQP4), a proteína de canal de água mais abundante no sistema nervoso central.
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Genética e causas
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Os sinais que médicos procuram e os exames que confirmam
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Publicações mais relevantes
Rare demyelinating diseases of the central nervous system: A diagnostic and therapeutic challenge - based on the case of a young woman with MOGAD.
Demyelinating diseases of the central nervous system constitute a heterogeneous group of diseases. The best known is multiple sclerosis, while neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare diseases. A 19-year-old female patient was admitted to the neurology department due to rapidly progressing memory and speech disorders. Mild mixed aphasia and right-sided pyramidal syndrome were diagnosed. Magnetic resonance imaging (MRI) of the brain revealed acute nodular demyelination in the left hemisphere. Intravenous methylprednisolone was administered. After approximately 2 months, the patient was readmitted due to several generalized epileptic seizures. At that time, the patient was transferred to a clinical center, where extensive diagnostics was performed. Among others, acute disseminated encephalitis, autoimmune encephalitis, tumefactive multiple sclerosis, and tumor were taken into consideration. MRI with spectroscopy and angiography revealed degenerative changes following acute demyelination. General examination of the cerebrospinal fluid was normal. No anti-neuronal antibodies were detected. However, positive anti-MOG antibodies were detected (and antibodies against aquaporin 4 were negative), which led to a suspicion of MOGAD. The patient was discharged home with a recommendation to use antiepileptic drugs and oral steroids. It is important to remember about rare demyelinating diseases, such as MOGAD, which require differentiation from multiple sclerosis. The prognosis for this condition is generally better, but the disease can lead to permanent neurological damage.
Double Anti-NMO and Anti-MOG Positivity in a Patient With Metastatic Renal Carcinoma: First Reported Case.
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD) are central nervous system (CNS) demyelinating disorders characterized by autoantibodies targeting aquaporin-4 (AQP4) and MOG, respectively. Although dual positivity for AQP4-IgG and MOG-IgG antibodies is uncommon, it poses significant diagnostic and therapeutic challenges due to its complex clinical features and uncertain prognosis. We present the first reported case in the literature of a patient with metastatic renal carcinoma who tested positive for both AQP4 and MOG antibodies. A 49-year-old man with a history of metastatic renal carcinoma experienced progressive neurological symptoms, initially attributed to tumor progression. However, after further investigation, including lumbar puncture and autoantibody testing, a demyelinating process with dual seropositivity for AQP4-IgG and MOG-IgG was identified. The patient was treated with high-dose corticosteroids, followed by rituximab, resulting in clinical and radiological stability. This case highlights the rare occurrence of dual seropositivity for AQP4 and MOG antibodies in a patient with a history of metastatic renal carcinoma, which poses diagnostic and treatment challenges. Although the pathogenesis remains unclear, factors such as genetic predisposition and autoimmune coactivation may contribute to triggering this autoimmune response. This case emphasizes the importance of personalized treatment and the need for further research to optimize management strategies for patients with this complex condition.
Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
Double seronegative neuromyelitis optica spectrum disorder (DN-NMOSD) is a rare autoimmune disease of the central nervous system, typically involving the optic nerve and spinal cord, characterized by negativity for anti-AQP4 and anti-MOG antibodies. A 35-year-old man with optic neuritis and recurrent myelitis, negative for AQP4 and MOG antibodies, was diagnosed with double seronegative NMOSD (DN-NMOSD). Initial treatment with Rituximab led to temporary stability, but relapses in 2021 and 2022 prompted a switch to Satralizumab (anti-IL-6R), achieving two years of clinical and radiological stability. This case underscores the therapeutic potential of anti-IL-6 drugs for DN-NMOSD, especially when anti-CD20 therapies fail. It highlights the heterogeneity of DN-NMOSD and the need for novel biomarkers, such as GFAP, tau, and IL-6, to better understand disease mechanisms and guide targeted treatments. A structured therapeutic approach, starting with anti-CD20 drugs and progressing to anti-IL-6 agents if ineffective, may optimize outcomes in this poorly understood condition.
Coronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
As compared to adults, less is known about the effects of SARS-CoV-2 infection in children with neuroinflammatory diseases, such as multiple sclerosis (MS), anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD). Moreover, the effects of SARS-CoV-2 vaccination on pediatric demyelinating diseases is also lesser known. Here, we examine the effects of SARS-CoV-2 infection and vaccination on children with demyelinating diseases. Retrospective chart review was performed at a single tertiary pediatric center, including 116 children with demyelinating diagnoses (MOGAD, MS, NMOSD, transverse myelitis-TM, and acute disseminated encephalomyelitis). Descriptive statistics and logistic regression were used. The diagnoses included: MS: 56/116 = 48%, MOGAD: 32/116 = 28%, NMOSD: 15/116 = 13%, acute disseminated encephalomyelitis: 12/116 = 10%, and TM: 1/116 = 1%. The known COVID infection rate was 26% = 30/116. Three of 30 (10%) of those with known infection were hospitalized. None of those hospitalized required intubation or ICU admission. Of the 30 with known infection, two (7%) had neuroinflammatory events that occurred within four weeks of infection, both of which were their first clinical events for MS. SARS-CoV-2 vaccination was not associated with any new onset or relapse neuroinflammatory events in our cohort. Demyelinating diagnosis and anti-CD20 mAbs were associated with known SARS-CoV-2 infection. Two participants had an initial clinical MS event associated with infection. However, we found no association with SARS-COV-2 vaccination or infection with relapses and no long-term adverse outcomes with SARS-CoV-2 vaccination or infection. Future larger multicenter studies should prospectively compare how infection and vaccination affects children and adults with demyelinating diseases.
Confusing Onset of MOGAD in the Form of Focal Seizures.
MOGAD is a demyelinating syndrome with the presence of antibodies against myelin oligodendrocyte glycoprotein, which is, next to multiple sclerosis and the neuromyelitis optica spectrum, one of the manifestations of the demyelinating process, more common in the pediatric population. MOGAD can take a variety of clinical forms: acute disseminated encephalomyelitis (ADEM), retrobulbar optic neuritis, often binocular (ON), transverse myelitis (TM), or NMOSD-like course (neuromyelitis optica spectrum disorders), less often encephalopathy. The course may be monophasic (40-50%) or polyphasic (50-60%), especially with persistently positive anti-MOG antibodies. Very rarely, the first manifestation of the disease, preceding the typical symptoms of MOGAD by 8 to 48 months, is focal seizures with secondary generalization, without typical demyelinating changes on MRI of the head. The paper presents a case of a 17-year-old patient whose first symptoms of MOGAD were focal epileptic seizures in the form of turning the head to the right with the elevation of the left upper limb and salivation. Seizures occurred after surgical excision of a tumor of the right adrenal gland (ganglioneuroblastoma). Then, despite a normal MRI of the head and the exclusion of onconeural antibodies in the serum and cerebrospinal fluid after intravenous treatment, a paraneoplastic syndrome was suspected. After intravenous steroid treatment and immunoglobulins, eight plasmapheresis treatments, and the initiation of antiepileptic treatment, the seizures disappeared, and no other neurological symptoms occurred for nine months. Only subsequent relapses of the disease with typical radiological and clinical picture (ADEM, MDEM, recurrent ON) allowed for proper diagnosis and treatment of the patient both during relapses and by initiating supportive treatment. The patient's case allows us to analyze the multi-phase, clinically diverse course of MOGAD and, above all, indicates the need to expand the diagnosis of epilepsy towards demyelinating diseases: determination of anti-MOG and anti-AQP4 antibodies.
Publicações recentes
Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
[Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): What controversies remain?].
French guidelines for the diagnosis and management of MOG antibody-associated disease.
Clinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
Polyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
📚 EuropePMCmostrando 144
Rare demyelinating diseases of the central nervous system: A diagnostic and therapeutic challenge - based on the case of a young woman with MOGAD.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa LekarskiegoDouble Anti-NMO and Anti-MOG Positivity in a Patient With Metastatic Renal Carcinoma: First Reported Case.
Case reports in neurological medicineMultifocal Presentations of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Case Series From a District General Hospital in South East England.
CureusDouble-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
BMC neurology[Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): What controversies remain?].
MedicinaAn Emerging Autoimmune Neuroinflammatory Disease: Myelin Oligodendrocyte Glycoprotein Antibody Disease.
Annals of African medicineFrench guidelines for the diagnosis and management of MOG antibody-associated disease.
Revue neurologiqueCoronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
Pediatric neurologyHerpes Zoster Myelitis Mimicking Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Disease: A Case Report.
CureusConfusing Onset of MOGAD in the Form of Focal Seizures.
Neurology internationalClinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
Scientific reportsNew-Onset Multiple Sclerosis in Pregnancy: Diagnostic Approaches and Treatment Dilemmas.
CureusThe Varying Faces of MOGAD: A Case Series.
Annals of African medicinePolyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersA rare case of systemic lupus erythematosus-associated neuromyelitis optica spectrum disorder with cystic lesions and dual seropositivity for anti-AQP4 and anti-MOG antibodies.
Clinical case reportsReversible Bilateral Vision Loss: An Unusual Presentation of Wernicke-Korsakoff Syndrome.
CureusIndirect Immunofluorescence-Aided Detection of Antimyelin Oligodendrocyte Glycoprotein Antibodies in Neuromyelitis Optica Spectrum Disorder/Myelin Oligodendrocyte Glycoprotein-Associated Antibody Disorder: A Case Series Involving Five Patients.
Annals of African medicineMOG CNS Autoimmunity and MOGAD.
Neurology(R) neuroimmunology & neuroinflammationRituximab Therapy for Double Seronegative Neuromyelitis Optica Spectrum Disease.
CureusClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein.
Balkan medical journal[Anti-MOG associated disease].
Revue medicale suisseClinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines.
Diseases (Basel, Switzerland)An aggressive form of MOGAD treated with aHSCT: A case report.
Multiple sclerosis (Houndmills, Basingstoke, England)Clinical spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease in Brazil: a single-center experience.
Arquivos de neuro-psiquiatriaUnderstanding MOG antibody-associated disease in Brazil.
Arquivos de neuro-psiquiatriaDual positivity for anti-MOG and oligoclonal bands: Unveiling unique clinical profiles and implications.
Multiple sclerosis and related disordersPathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
International journal of molecular sciencesDiagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report.
Frontiers in neuroscienceParacentral Acute Middle Maculopathy Associated with Severe Anti-Mog (Myelin Oligodendrocyte Glycoprotein)-Positive Optic Neuritis.
Neuro-ophthalmology (Aeolus Press)Establishment of a comprehensive diagnostic model for neuromyelitis optica spectrum disorders based on the analysis of laboratory indicators and clinical data.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyA comparative analysis of demographic, clinical and imaging features of myelin oligodendrocyte glycoprotein antibody positive, aquaporin 4 antibody positive, and double seronegative demyelinating disorders - An Indian tertiary care center prospective study.
Journal of neurosciences in rural practiceClinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Multiple sclerosis and related disordersMyelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?
Journal of neuroradiology = Journal de neuroradiologieA Quality Assessment of Aquaporin-4 & Myelin Oligodendrocyte Glycoprotein Antibody Testing.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesArea Postrema Syndrome: An Initial Presentation of Double-Seropositive AQP4 and MOG Antibodies.
Neurology. Clinical practiceDouble seropositive neuromyelitis optica associated with COVID-19: A case report.
Frontiers in neurologyThe Prevalence, Demographics, Clinical Features, Neuroimaging, and Inter-ethnic Differences of MOGAD in Malaysia with Global Perspectives.
Multiple sclerosis and related disordersNeuromyelitis optica spectrum disorder with negative aquaporin-4 antibodies and positive anti-myelin oligodendrocyte glycoprotein antibodies: A case report.
Medical journal, Armed Forces IndiaRe-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyMyelin Oligodendrocyte Glycoprotein-Associated Disorders.
Continuum (Minneapolis, Minn.)Neuromyelitis optica spectrum disorders and anti-myelin oligodendrocyte glycoprotein positive optic neuropathies.
International journal of ophthalmologyComparison of Clinical and Radiological Features of Aquaporin4 (AQP-4) Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD) and Anti Myelin Oligodendrocyte Glycoprotein (Anti-MOG) Syndrome-Our Experience from Northwest India.
Annals of Indian Academy of NeurologyLate onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups.
Multiple sclerosis and related disordersOptic Neuritis in the Era of NMOSD and MOGAD: A Survey of Practice Patterns in Singapore.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD.
Journal of the neurological sciencesNeuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study.
Neurology internationalTreatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Journal of neuroinflammationUpdate on Optic Neuritis: An International View.
Neuro-ophthalmology (Aeolus Press)Pediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Multiple sclerosis and related disordersAcute Demyelinating Syndromes: A report of child neurology department of Sfax University Hospital.
Multiple sclerosis and related disordersRecurrent Bilateral Optic Neuritis Associated with Myelin Oligodendrocyte Glycoprotein Antibody: A Case Report from Nepal.
Case reports in neurological medicineFive-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease.
Multiple sclerosis and related disordersMyelin-oligodendrocyte glycoprotein antibody-associated disease.
The Lancet. NeurologyApplication of deep-learning to the seronegative side of the NMO spectrum.
Journal of neurologyConus medullaris involvement in demyelinating disorders of the CNS: A comparative study.
Multiple sclerosis and related disordersAseptic meningitis and leptomeningeal enhancement associated with anti-MOG antibodies: A review.
Journal of neuroimmunologyMOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response.
Brain : a journal of neurology[Anti-Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease].
Brain and nerve = Shinkei kenkyu no shinpoNo strong HLA association with MOG antibody disease in the UK population.
Annals of clinical and translational neurologyDifference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder.
NeurologyAcute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyangiitis: A case report.
MedicineHemicraniectomy and externalized ventricular drain placement in a pediatric patient with myelin oligodendrocyte glycoprotein-associated tumefactive demyelinating disease.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryProgressive Leukodystrophy-Like Demyelinating Syndromes with MOG-Antibodies in Children: A Rare Under-Recognized Phenotype.
NeuropediatricsLongitudinal Evaluation of Serum MOG-IgG and AQP4-IgG Antibodies in NMOSD by a Semiquantitative Ratiometric Method.
Frontiers in neurologyMeningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report.
BMC neurologyThe efficacy of rituximab in patients with neuromyelitis optica spectrum disorder: A real-world study from Turkey.
International journal of clinical practiceEfficacy for the Annual Relapse Rate after the Immunosuppressive Therapy in Patients Associated with Anti-AQP4 or Anti-MOG Antibody-Positive Optic Neuritis.
Journal of ophthalmologyAnti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Multiple sclerosis and related disordersProgression pattern of neurological disability with respect to clinical attacks in anti-MOG antibody-associated disorders.
Journal of neuroimmunologyMOG-IgG-associated disorder and systemic lupus erythematosus disease: Systematic review.
LupusAnti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany.
Journal of neurology, neurosurgery, and psychiatryAtypical Multiple Sclerosis with Antibody to MOG.
Neurology IndiaRole for OCT in detecting hemi-macular ganglion cell layer thinning in patients with multiple sclerosis and related demyelinating diseases.
Journal of the neurological sciencesClinical outcomes of transverse myelitis with myelin oligodendrocyte glycoprotein antibody versus negative cases among adults in Isfahan, Iran: A comparative study.
Current journal of neurologyAn update on epidemiology, diagnosis & management of NMO-SD in the tertiary neurology department of Marrakech (Morocco).
Revue neurologiqueSingle-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders.
Cellular & molecular immunology[Atypical optic neuritis: the importance of a comprehensive diagnostic work-up].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen GesellschaftAutoimmune and demyelinating optic neuritis.
Archivos de la Sociedad Espanola de OftalmologiaUnilateral Optic Neuritis in Children: Experience of a Tertiary Centre.
European neurologyAnti-MOG and Anti-AQP4 positive neuromyelitis optica spectrum disorder in a patient with myasthenia gravis.
Multiple sclerosis and related disordersCase Series: Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Related Disease Spectrum.
Frontiers in neurologyA Fulminant Case of Demyelinating Encephalitis With Extensive Cortical Involvement Associated With Anti-MOG Antibodies.
Frontiers in neurology[Anti-myelin oligodendrocyte glycoprotein antibody-positive neurologic disease, manifested as clinical course of classical Devic's disease: A case report].
Rinsho shinkeigaku = Clinical neurologyAssociations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: a multicentre observational study.
The Lancet. NeurologyUse of ganglion cell layer analysis for diagnosing anti-glycoprotein neuromyelitis optica of oligodendrocyte myelin.
Archivos de la Sociedad Espanola de Oftalmologia[Anti-myelin oligodendrocyte glycoprotein antibody associated encephalitis].
Rinsho shinkeigaku = Clinical neurologyDeciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays.
Journal of the neurological sciencesNeuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.
Journal of child neurology[Optic neuropathy in positive anti-MOG antibody syndrome].
Journal francais d'ophtalmologieCNS inflammatory demyelinating disorders: MS, NMOSD and MOG antibody associated disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical ResearchClinical and radiologic approach to 'typical' versus antibody-related optic neuritis.
Current opinion in ophthalmologyThe accuracy of flow cytometric cell-based assay to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies determining the optimal method for positivity judgement.
Journal of neuroimmunologyA young woman with seizures, visual impairment, and paralysis.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekkeA unique case of multiphasic ADEM or what else?
Multiple sclerosis and related disordersTwo Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease.
Journal of neuroimmunologyIncidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 2008‒2018: A nationwide, population-based cohort study.
Multiple sclerosis and related disordersMRI features of demyelinating disease associated with anti-MOG antibodies in adults.
Journal of neuroradiology = Journal de neuroradiologieOptic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study.
Multiple sclerosis and related disordersNeuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes.
BiomedicinesThe clinical spectrum of anti-MOG associated acquired demyelinating disorders: Three case-reports.
Multiple sclerosis and related disordersSuccessful intravenous immunoglobulin treatment in relapsing MOG-antibody-associated disease.
Multiple sclerosis and related disordersAntibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes.
Scientific reportsLive-cell based assays are the gold standard for anti-MOG-Ab testing.
NeurologyAnti-MOG Antibody Seropositive Neuromyelitis Optica: A Rare Pediatric Case.
Noro psikiyatri arsiviAstrocytic damage in glial fibrillary acidic protein astrocytopathy during initial attack.
Multiple sclerosis and related disordersNeuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models.
Multiple sclerosis and related disordersClinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Multiple sclerosis and related disorders[Clinical analysis of opticospinal multiple sclerosis (OSMS) presentation detecting anti-myelin oligodendrocyte glycoprotein (MOG) antibody].
Rinsho shinkeigaku = Clinical neurologyPositive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis.
European journal of rheumatologyComparing myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and non MOG-Ab associated optic neuritis: Clinical course and treatment outcome.
Multiple sclerosis and related disordersInflammatory demyelinating diseases of the central nervous system in Niger.
Revue neurologiqueClinical utility of anti-MOG antibody testing in a Danish cohort.
Multiple sclerosis and related disordersNMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report.
Multiple sclerosis and related disordersRetrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders.
Multiple sclerosis and related disordersAnti-Myelin Oligodendrocyte Glycoprotein Antibody Associated With Gray Matter Predominant Transverse Myelitis Mimicking Acute Flaccid Myelitis: A Presentation of Two Cases.
Pediatric neurologyMOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response.
Multiple sclerosis journal - experimental, translational and clinicalLate-onset neutropenia and neurological relapse, during long-term rituximab therapy in myelin oligodendrocyte glycoprotein-antibody spectrum disorder.
Multiple sclerosis (Houndmills, Basingstoke, England)An unusual case of anti-MOG CNS demyelination with concomitant mild anti-NMDAR encephalitis.
Journal of neuroimmunology[Autoantibodies in Neuromyelitis Optica Spectrum Disorders].
Brain and nerve = Shinkei kenkyu no shinpoDefining distinct features of anti-MOG antibody associated central nervous system demyelination.
Therapeutic advances in neurological disordersPaediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.
European journal of neurologyAnti Myelin Oligodendrocyte Glycoprotein associated Immunoglobulin G (AntiMOG-IgG)-associated Neuromyelitis Optica Spectrum Disorder with Persistent Disease Activity and Residual Cognitive Impairment.
Annals of Indian Academy of Neurology[Anti-MOG Antibody Associated Diseases].
Brain and nerve = Shinkei kenkyu no shinpoSubclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.
Journal of neuroimmunologyUnderstanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets?
Arthritis & rheumatology (Hoboken, N.J.)[A case of recurrent myelitis associated with anti-myelin oligodendrocyte glycoprotein antibody that developed only as localized short spinal cord lesions].
Rinsho shinkeigaku = Clinical neurologyA case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection.
Multiple sclerosis and related disorders[Neuromyelitis optica with anti-MOG antibodies: A case report].
Journal francais d'ophtalmologiePostinfectious Anti-Myelin Oligodendrocyte Glycoprotein Antibody Positive Optic Neuritis and Myelitis.
Journal of child neurologyInfluence of type I IFN signaling on anti-MOG antibody-mediated demyelination.
Journal of neuroinflammationThe Role of Peripheral CNS-Directed Antibodies in Promoting Inflammatory CNS Demyelination.
Brain sciences[An asynchronous bilateral optic neuropathy with positive MOG antibodies].
Journal francais d'ophtalmologieAnti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report.
BMC neurologySerological markers associated with neuromyelitis optica spectrum disorders in South India.
Annals of Indian Academy of NeurologyDifferent etiologies and prognoses of optic neuritis in demyelinating diseases.
Journal of neuroimmunology[Anti-MOG + neuromyelitis optica spectrum disorders treated with plasmapheresis].
No to hattatsu = Brain and developmentLesion length of optic neuritis impacts visual prognosis in neuromyelitis optica.
Journal of neuroimmunologyMyelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.
Acta neuropathologicaAutoantibody to MOG suggests two distinct clinical subtypes of NMOSD.
Science China. Life sciencesAnti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.
Autoimmunity reviewsChange in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study.
Multiple sclerosis (Houndmills, Basingstoke, England)The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients.
Multiple sclerosis (Houndmills, Basingstoke, England)Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype.
Journal of neuroinflammationAntibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Rare demyelinating diseases of the central nervous system: A diagnostic and therapeutic challenge - based on the case of a young woman with MOGAD.Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego· 2026· PMID 41746891mais citado
- Double Anti-NMO and Anti-MOG Positivity in a Patient With Metastatic Renal Carcinoma: First Reported Case.
- Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
- Coronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
- Confusing Onset of MOGAD in the Form of Focal Seizures.
- [Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): What controversies remain?].
- French guidelines for the diagnosis and management of MOG antibody-associated disease.
- Clinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
- Polyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
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- ORPHA:592856(Orphanet)
- MONDO:0035664(MONDO)
- Neuromielite Optica(PCDT · Ministério da Saúde)
- GARD:22373(GARD (NIH))
- Busca completa no PubMed(PubMed)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
