Raras
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Hemicrania continua
ORPHA:443070CID-10 · G44.0CID-11 · 8A82DOENÇA RARA

Cefaleia ou cefalgia são os termos médicos para dor de cabeça. É um dos sintomas mais comuns na medicina. É uma das queixas mais frequentes de consultas a profissionais de saúde, e também um dos motivos mais comuns de falta ao trabalho. A cefaleia é um sintoma universal no ser humano.

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Introdução

O que você precisa saber de cara

📋

Dor de cabeça unilateral contínua, com exacerbações diárias, associada a sintomas autonômicos (lacrimejamento, congestão nasal, ptose) do mesmo lado. Responde completamente à indometacina.

Pesquisas ativas
2 ensaios
4 total registrados no ClinicalTrials.gov
Publicações científicas
457 artigos
Último publicado: 2026 Mar
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G44.0
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico457PubMed
Últimos 10 anos148publicações
Pico202122 papers
Linha do tempo
2026Hoje · 2026🧪 2016Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 21
1Fase 11
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 4 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Hemicrania continua

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

4 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

📖Melhor nível de evidência: Revisão
Timeline de publicações
151 papers (10 anos)
#1

Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.

Brain : a journal of neurology2026 Mar 05

Chronic headache disorders have a tremendous impact on psychosocial functioning. Despite the availability of various treatment options, suboptimal management remains present in a subset of patients, leading to persistent suffering. Molecular mechanisms, regional activity patterns and connectivity pathways are crucial for understanding the pathophysiology, serving as a foundation for developing novel treatments, refining existing therapies, and ultimately optimizing the management of headache disorders. Nevertheless, articles combining fundamental and clinical aspects of the pathophysiology and treatment of headache disorders remain limited. The current literature review provides a thorough overview of the molecular mechanisms, regional activity patterns and connectivity pathways involved in migraine, cluster headache (CH), paroxysmal hemicrania (PH), hemicrania continua (HC) and occipital neuralgia (ON), thereby bridging the gap between different fields of expertise. In this scoping review, literature on molecular mechanisms, regional activity and connectivity pathways for migraine, CH, PH, HC and ON has been collected from the PubMed, MEDLINE and EMBASE databases. Reports were also manually searched using the search function in Google Scholar, as well as reviews or references cited within the articles. In total, 130 and 97 articles, published between 1976 and 2024, are included in the analysis of the molecular mechanism and regional activity patterns/connectivity pathways, respectively. Molecular data show that the trigeminal nucleus caudalis is a central structure in headache pathology, comprising various neuropeptides and neurochemicals, including vasoactive intestinal peptide, glutamate, substance P and serotonin, and connecting the pathophysiology of these headache disorders. Sensitization of higher cortical brain areas, neuroinflammation within the trigeminal system and vasodilatation of cranial vessels seem to contribute to headache pain. Headache disorders are also associated with atypical regional activity patterns and connectivity pathways in pain processing areas, as well as the default mode network, salience network, and sensorimotor network. These abnormalities help explain the mechanisms underlying overall headache-related symptoms and additional manifestations unique to each headache disorder, including cortical spreading depression in migraine, rhythmicity of attacks in CH and autonomic symptoms in CH, PH and HC. The article fosters a deeper understanding of the molecular mechanisms, neuronal pathways and clinical symptoms involved in headache pathology across different fields of expertise. By bridging these perspectives, it provides essential insights for developing innovative treatment strategies and enhancing existing therapeutic options.

#2

Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.

Journal of child neurology2026 Mar

BackgroundHemicrania continua and paroxysmal hemicrania are rare in the pediatric population. Recognizing these disorders characterized by unilateral headaches with autonomic features can reduce time to diagnosis, facilitate effective medical treatment, and reduce morbidity.ObjectiveTo review the diagnostic criteria and pathophysiology of hemicrania continua and paroxysmal hemicrania, analyze a retrospective cohort of adolescent patients with indomethacin-responsive headaches, and discuss the clinical features of these patients, both in how they follow the diagnostic criteria for these disorders and how they may deviate. We also examined time to diagnosis and prognosis for this cohort.MethodsA retrospective chart review was completed of patients 12-18 years old from 2014 to 2021 diagnosed with indomethacin-responsive headaches who presented to a tertiary pediatric headache clinic. Clinical headache characteristics, demographic features, medical diagnoses, and diagnostic testing were reviewed and collated.ResultsEight patients (7 female, 1 male) had indomethacin-responsive headaches. Six patients were diagnosed with hemicrania continua and 2 were diagnosed with paroxysmal hemicrania. The most common autonomic symptoms were unilateral nasal congestion and conjunctival injection/lacrimation. The median time to diagnosis was 15 months, and the median treatment length was 7 months.ConclusionPatients can have multiple headache phenotypes. Clinicians should ask headache patients of all ages about autonomic symptoms and unilateral headaches, specifically in fixed unilateral headaches. These headaches should be evaluated with imaging to rule out secondary intracranial causes. In those cases, with these features, an indomethacin trial is part of the diagnosis and should be considered early in the course.

#3

Hemicrania continua exacerbations with prodromal burping as a potential autonomic symptom.

Headache2026 Mar
#4

Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.

BMC neurology2025 Jul 21

The study of the trigeminal autonomic cephalalgias (TAC) has been limited by difficulty aggregating sufficient numbers of patients. We used the Epic Cosmos electronic health record research platform to harness nationwide data from health care systems across the United States using the Epic electronic health record to analyze the prevalence, demographics, comorbid conditions and treatments for the TACs. We queried the Epic Cosmos electronic health record database for patients with diagnoses of hemicrania continua, cluster headache, paroxysmal hemicrania, and SUNCT. Prevalences, demographics were determined from this database and comorbid conditions and treatments for these conditions were analyzed. Our study included 152,727 patients with cluster headache, 59,312 patients with paroxysmal hemicrania, 19,321 patients with hemicrania continua, and 6,291 patients with SUNCT. Five-year prevalence of cluster headache was highest (56.7 per 100,000), followed by paroxysmal hemicrania (22.0 per 100,000), hemicrania continua (7.2 per 100,000) and SUNCT (2.3 per 100,000). All four TACs showed a higher prevalence in women. Migraine was common in all four conditions and patients with cluster headache had the highest rates of nicotine, alcohol, and cannabis use disorders. Indomethacin was notably underutilized for the indomethacin-responsive TACs. We use a national electronic medical record database to give insight into elements of the TACs that have been previously limited by the relative rarity of these diseases.

#5

How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?

Current opinion in neurology2025 Jun 01

Paroxysmal hemicrania and hemicrania continua are rare primary headache disorders which are distinguished by an absolute response to indomethacin. As a matter of importance, no guidelines have been proposed for alternative therapeutic options in case of indomethacin intolerance. The purpose of this review is to provide an update on the current findings, especially focusing on the past 18 months, in the treatment of both paroxysmal hemicrania and hemicrania continua and to provide proposed management recommendations based on summarized evidence. Apart from well recognized gastrolesive effects of indomethacin, a substantial number of patients may suffer from neuropsychiatric adverse reactions. Recent studies demonstrated that melatonin, which has been known for its effectiveness for hemicrania continua, is also useful for paroxysmal hemicrania. Promising nonpharmacological treatment option, which is noninvasive vagus nerve stimulation, has been shown to be beneficial for both indomethacin-responsive headache disorders allowing the reduction of indomethacin dosage. Although the data on substitutive medication choice for indomethacin are currently scarce, the most consistent results have been repeatedly achieved with acemethacin, selective COX-2 inhibitors, and anticonvulsants. However, considering the crucial role of pathophysiology, research investigating the efficacy of drugs targeting the trigemino-vascular system activation, as well as controlled trials assessing the efficacy involving the aforementioned therapeutic options are still vague. In spite of numerous reports suggesting reliable alternatives to indomethacin, the consensus on pharmacological therapy guidelines for indomethacin-responsive headache disorders has not yet been reached. Further research and agreement from the experts' standpoint are needed for an establishment of reliable treatment recommendations.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC249 artigos no totalmostrando 141

2026

Hemicrania continua exacerbations with prodromal burping as a potential autonomic symptom.

Headache
2025

A Comprehensive Review of Trigeminal Autonomic Cephalalgias.

Physical medicine and rehabilitation clinics of North America
2025

Primary stabbing headache in a tertiary headache centre.

The journal of headache and pain
2026

Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.

Brain : a journal of neurology
2025

Neuromodulation in trigeminal autonomic cephalalgias: 11-year experience of non-invasive vagus nerve stimulation.

Cephalalgia : an international journal of headache
2026

Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.

Journal of child neurology
2025

Uses of Botulinum Toxin in Headache and Facial Pain Disorders: An Update.

Toxins
2025

Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.

BMC neurology
2025

Third Occipital Nerve Block and Cooled Radiofrequency Ablation for Managing Hemicrania Continua: A Case Report.

Cureus
2025

The Role of Multiple Peripheral Nerve Blockades in the Treatment of Hemicrania Continua.

Pain practice : the official journal of World Institute of Pain
2025

Massive arachnoid granulation in the transverse sinuses on CT myelogram.

Radiology case reports
2025

Indomethacin-responsive refractory headache: Two case reports in children after hemispherectomy for Rasmussen's encephalitis.

Headache
2025

Trigeminal autonomic cephalalgia after common eye surgery: Case series and literature review.

Revue neurologique
2025

Hemicrania continua with rhinosinusitis: a case report.

Korean journal of family medicine
2025

How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?

Current opinion in neurology
2024

World neurology updates: Other primary headache disorder - Treatment.

eNeurologicalSci
2024

Neurological and Systemic Pitfalls in the Diagnosis of Cluster Headaches: A Case-Based Review.

Current neurology and neuroscience reports
2024

Pharmacological Dissociation in Hemicrania Continua With Persistent Visual Aura Evolved From Episodic Migraine: A Case Report.

The neurologist
2024

Harlequin syndrome in a patient with probable hemicrania continua and exertional headache - is there a link? a case report.

BMC neurology
2024

Indomethacin-responsive trigeminal autonomic cephalgias: a review of key characteristics and pathophysiology.

Neurologia i neurochirurgia polska
2024

Bilateral Calcification of the Meckel Cave Causing Hemicrania Continua.

JAMA neurology
2024

The critical role of neuroimaging in hemicrania continua: A systematic review and case series.

Headache
2024

Herpes Zoster Ophthalmicus Initially Diagnosed As Cluster Headache, Complicated by Delayed Eruption.

Cureus
2024

Indomethacin-Responsive Headache Disorders.

Continuum (Minneapolis, Minn.)
2024

Melatonin in hemicrania continua and paroxysmal hemicrania.

Cephalalgia : an international journal of headache
2024

Conjugal Hemicrania Continua - A Chance Occurrence or a New Entity?

Annals of Indian Academy of Neurology
2024

One-year prevalence of cluster headache, hemicrania continua, paroxysmal hemicrania and SUNCT in Norway: a population-based nationwide registry study.

The journal of headache and pain
2024

Complementary and Integrative Medicine for the Treatment of Trigeminal Neuralgia and Trigeminal Autonomic Cephalalgia.

Current pain and headache reports
2023

Paroxysmal hemicrania and hemicrania continua: Review on pathophysiology, clinical features and treatment.

Cephalalgia : an international journal of headache
2023

Cigarette smoking history (personal and secondary childhood exposure) in non-cluster headache trigeminal autonomic cephalalgias: A clinic based study.

Cephalalgia : an international journal of headache
2023

Trigeminal Autonomic Cephalalgias and Neuralgias in Children and Adolescents: a Narrative Review.

Current neurology and neuroscience reports
2023

Hemicrania Continua: An Update.

Current pain and headache reports
2023

Chronic Unilateral Headache Related to Scar Neuromas.

Journal of medical cases
2023

Symptomatic trigeminal autonomic cephalalgias in neuromyelitis optica spectrum disorders.

Multiple sclerosis and related disorders
2023

Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches.

Frontiers in pain research (Lausanne, Switzerland)
2023

Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster: A Review.

JAMA neurology
2023

Prevalence and clinical features of hemicrania continua in clinic-based studies: A systematic review and meta-analysis.

Cephalalgia : an international journal of headache
2022

Recent Advances and Updates in Trigeminal Autonomic Cephalalgias.

Seminars in neurology
2022

[Acemetacin, a Prodrug of Indomethacin, Is Effective for Treatment of Hemicrania Continua: A Japanese Case Report].

Brain and nerve = Shinkei kenkyu no shinpo
2022

Indomethacin Resistant Hemicrania Continua Responsive to Venlafaxine.

Neurology India
2023

Traumatic Brain Injury Temporal Lesion Causing Hemicrania Continua.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2022

Increase in CGRP levels in a case of hemicrania continua normalizes after a successful response to galcanezumab.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2022

Diagnosis and management of traumatically induced hemicrania continua and neuropathic pain secondary to facial gun shot wound.

Journal of oral rehabilitation
2022

Paroxysmal hemicrania or short-lasting unilateral neuralgiform headache attacks with trigeminal neuralgia - functional neuroimaging findings.

Neurologia i neurochirurgia polska
2022

The spectrum of indomethacin-responsive headaches in children and adolescents.

Cephalalgia : an international journal of headache
2022

[Autonomic Disorders in Trigeminal Autonomic Cephalalgias: An Update].

Brain and nerve = Shinkei kenkyu no shinpo
2022

Tolosa-Hunt syndrome presenting with features of a trigeminal autonomic cephalalgias and pituitary enlargement.

BMJ case reports
2022

Cranial autonomic symptoms: prevalence, phenotype and laterality in migraine and two potentially new symptoms.

The journal of headache and pain
2021

[Trigeminal autonomic cephalgias: features of diagnosis and treatment].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2022

Co-morbidity between trigeminal autonomic cephalalgias and complex regional pain syndrome: Two case reports.

Cephalalgia : an international journal of headache
2021

Temporary resolution of hemicrania continua following ipsilateral ear piercing.

BMJ neurology open
2021

Headache Associated with Sexual Activity-A Narrative Review of Literature.

Medicina (Kaunas, Lithuania)
2022

Hemicrania continua secondary to neurogenic paravertebral tumor- a case report.

Scandinavian journal of pain
2022

Aura in trigeminal autonomic cephalalgia is probably mediated by comorbid migraine with aura.

Cephalalgia : an international journal of headache
2021

Pediatric-onset trigeminal autonomic cephalalgias: A systematic review and meta-analysis.

Cephalalgia : an international journal of headache
2022

Indomethacin has no effect on trigeminally provoked parasympathetic output.

Cephalalgia : an international journal of headache
2021

Hemicrania continua in a family: A report of two cases.

Headache
2021

Beyond chronic migraine: a systematic review and expert opinion on the off-label use of botulinum neurotoxin type-A in other primary headache disorders.

Expert review of neurotherapeutics
2021

First case of hemicrania continua responsive to galcanezumab.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

The Promising Effect of Nerve Decompression in Trigeminal Autonomic Cephalalgias: Report of Case Series.

Frontiers in neurology
2021

[Blepharyplasty as treatment of chronic headache].

Ugeskrift for laeger
2021

Hemicrania continua secondary to pituitary macroadenoma responsive to nerve blocks: A case report.

Headache
2021

Indomethacin-responsive headaches-A narrative review.

Headache
2021

Hemicrania continua: Indomethacin induced myoclonus.

Clinical neurology and neurosurgery
2021

Secondary hemicrania continua-tic syndrome associated with fungal sphenoiditis: A case report.

Clinical case reports
2021

Noninvasive Neuromodulation in Headache: An Update.

Neurology India
2021

Paroxysmal Hemicrania: An Update.

Neurology India
2021

Headache from clinically confirmed hemicrania continua arising from the sternocleidomastoid muscle: a case report.

BMC neurology
2021

Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding.

European journal of neurology
2021

Hemicrania continua associated with an unruptured anterior communicating artery aneurysm: first case report.

The journal of headache and pain
2020

Radiofrequency Ablation of the Sphenopalatine Ganglion for Hemicrania Continua: The Second Case Report of a Long-Term Pain-Free Response.

Headache
2021

Outcomes of Occipital Nerve Stimulation for Craniofacial Pain Syndromes.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2020

Hemicrania Continua With Scintillating Scotoma: A Rare Presentation.

Cureus
2020

Hemicrania Continua and Pituitary Microadenoma - Post Hoc Ergo Propter Hoc?: A Case Report With a Side Note on Intra-Sellar Pressure and the Trigemino-Autonomic Reflex.

Cureus
2020

Cluster headache and TACs: state of the art.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Differential actions of indomethacin: clinical relevance in headache.

Pain
2020

[Cluster headache and other trigeminal autonomic cephalalgias].

Nederlands tijdschrift voor geneeskunde
2020

Very young age of onset in trigemino-autonomic cephalalgias - case report and review of the literature.

Cephalalgia : an international journal of headache
2019

Hemicrania Continua Subsequent to Vertebral Artery Dissection: A Case Report.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2019

Trigeminal Autonomic Cephalalgias.

Neurologic clinics
2019

Diagnostic Testing for Migraine and Other Primary Headaches.

Neurologic clinics
2019

Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes.

Neurology
2019

Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2019

Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic.

The journal of headache and pain
2019

Carotid Cavernous Fistula Mimicking Hemicrania Continua: A Case Report.

Headache
2019

A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache.

BMJ case reports
2019

Multiple cranial nerve blocks for the transitional treatment of chronic headaches.

Cephalalgia : an international journal of headache
2019

Chronic persistent Horner's syndrome in trigeminal autonomic cephalalgia subtypes and alleviation with treatment: two case reports.

Journal of medical case reports
2019

Topiramate as an Indomethacin-Sparing Agent in Hemicrania Continua: A Report of 2 Cases.

Headache
2019

Nonmigraine Headache and Facial Pain.

The Medical clinics of North America
2019

The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Journal of oral & facial pain and headache
2019

The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia.

Internal medicine (Tokyo, Japan)
2018

Hemicrania Continua: a Clinical Perspective on Diagnosis and Management.

Current neurology and neuroscience reports
2018

Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Continuum (Minneapolis, Minn.)
2018

New daily persistent headache: An evolving entity.

Neurology India
2018

Secondary (Symptomatic) Trigeminal Autonomic Cephalalgia.

Annals of Indian Academy of Neurology
2018

Functional Neuroimaging in Trigeminal Autonomic Cephalalgias.

Annals of Indian Academy of Neurology
2018

Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta?

Annals of Indian Academy of Neurology
2018

Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management.

Annals of Indian Academy of Neurology
2018

Hemicrania Continua Associated with Classic Scintillating Scotoma.

Case reports in neurology
2018

Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua.

BMJ case reports
2018

Hemicrania continua: Case series presenting in an orofacial pain clinic.

Cephalalgia : an international journal of headache
2018

Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2020

Evidence of and experience with the use of onabotulinumtoxinA in trigeminal neuralgia and primary headaches other than chronic migraine.

Neurologia
2018

The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society
2018

Predictors of response to occipital nerve stimulation in refractory chronic headache.

Cephalalgia : an international journal of headache
2018

Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience.

Cephalalgia : an international journal of headache
2017

Primary Headache Disorders Part I- Migraine and the Trigeminal Autonomic Cephalalgias.

Disease-a-month : DM
2017

Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal.

The journal of headache and pain
2017

Hemicrania continua: clinical review, diagnosis and management.

Journal of pain research
2017

LASH: A Review of the Current Literature.

Current pain and headache reports
2017

Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions.

Headache
2017

Orofacial pain and headaches associated with exfoliation glaucoma.

Journal of the American Dental Association (1939)
2018

Idiopathic hypertrophic pachymeningitis mimicking hemicrania continua: An unusual clinical case.

Cephalalgia : an international journal of headache
2017

Sphenopalatine Ganglion Block in the Management of Chronic Headaches.

Current pain and headache reports
2017

Treatment of intractable hemicrania continua by occipital nerve stimulation.

Journal of neurology, neurosurgery, and psychiatry
2017

Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases.

Quintessence international (Berlin, Germany : 1985)
2015

Hemicrania continua and unilateral headaches: are they still together in the IHS classification?

The journal of headache and pain
2017

Cluster headache and other TACs: Pathophysiology and neurostimulation options.

Headache
2018

Hemicrania continua in carotid artery dissection - symptomatic cases or linked pathophysiology?

Cephalalgia : an international journal of headache
2017

Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy.

Headache
2017

Hemicrania Continua: Beneficial Effect of Non-Invasive Vagus Nerve Stimulation in a Patient With a Contraindication for Indomethacin.

Headache
2016

Side-locked headaches: an algorithm-based approach.

The journal of headache and pain
2017

Two Cases of Hemicrania Continua-Trigeminal Neuralgia Syndrome: Expanding the Spectrum of Trigeminal Autonomic Cephalalgia-Tic (TAC-TIC) Syndrome.

Headache
2016

Case Studies of Uncommon and Rare Headache Disorders.

Neurologic clinics
2016

The Role of Melatonin in the Treatment of Primary Headache Disorders.

Headache
2017

Hemicrania continua-like headache secondary to nasopharyngeal carcinoma: A case report.

Cephalalgia : an international journal of headache
2016

A Cross-Sectional Clinic-Based Study in Patients With Side-Locked Unilateral Headache and Facial Pain.

Headache
2017

Headache in military service members with a history of mild traumatic brain injury: A cohort study of diagnosis and classification.

Cephalalgia : an international journal of headache
2016

Alcohol-induced headaches: Evidence for a central mechanism?

Journal of neurosciences in rural practice
2016

Hemicrania continua may respond to repetitive sphenopalatine ganglion block: A case report.

Headache
2016

Update of Inpatient Treatment for Refractory Chronic Daily Headache.

Current pain and headache reports
2015

The Neuropharmacology of Cluster Headache and other Trigeminal Autonomic Cephalalgias.

Current neuropharmacology
2015

Postoperative hemicrania continua-like headache - a case series.

The journal of headache and pain
2015

Hemicrania continua with contralateral cranial autonomic features: a case report.

The journal of headache and pain
2015

OnabotulinumtoxinA for hemicrania continua: open label experience in 9 patients.

The journal of headache and pain
2015

Raeder paratrigeminal neuralgia evolving to hemicrania continua.

Optometry and vision science : official publication of the American Academy of Optometry
2015

When indomethacin fails: additional treatment options for "indomethacin responsive headaches".

Current pain and headache reports
2015

Treatment of hemicrania continua with radiofrequency ablation and long-term follow-up.

Cephalalgia : an international journal of headache
2015

How effective is melatonin as a preventive treatment for hemicrania continua? A clinic-based study.

Headache
2015

[Trigeminal autonomic cephalgias].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Ver todos os 249 no EuropePMC

Associações

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Hemicrania continua

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.
    Brain : a journal of neurology· 2026· PMID 40995873mais citado
  2. Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.
    Journal of child neurology· 2026· PMID 40717615mais citado
  3. Hemicrania continua exacerbations with prodromal burping as a potential autonomic symptom.
    Headache· 2026· PMID 41502363mais citado
  4. Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.
    BMC neurology· 2025· PMID 40691779mais citado
  5. How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?
    Current opinion in neurology· 2025· PMID 39911098mais citado
  6. A Comprehensive Review of Trigeminal Autonomic Cephalalgias.
    Phys Med Rehabil Clin N Am· 2025· PMID 41167853recente
  7. Primary stabbing headache in a tertiary headache centre.
    J Headache Pain· 2025· PMID 41102620recente
  8. Neuromodulation in trigeminal autonomic cephalalgias: 11-year experience of non-invasive vagus nerve stimulation.
    Cephalalgia· 2025· PMID 40888687recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:443070(Orphanet)
  2. MONDO:0018615(MONDO)
  3. GARD:10795(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q973425(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Hemicrania continua
Compêndio · Raras BR

Hemicrania continua

ORPHA:443070 · MONDO:0018615
CID-10
G44.0 · Síndrome de "cluster-headache"
CID-11
Ensaios
2 ativos
MedGen
UMLS
C2349425
EuropePMC
Wikidata
Wikipedia
Papers 10a
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