Hepatite autoimune

Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome

NCT06519162

Belimumab in Autoimmune Hepatitis

NCT06381453

A Study of SIPLIZUMAB in AILD and LT Patients

NCT06455280

Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation

NCT04902807

Swiss Autoimmune Hepatitis Cohort Study

NCT03146884

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Publicações mais relevantes

Timeline de publicações

4.309 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 4.309

#1

Anti-MRPS27 Antibody: A Novel Diagnostic Biomarker for Autoimmune Hepatitis Identified via a Human Proteome Microarray.

Hepatology research : the official journal of the Japan Society of Hepatology2026 Mar 23

To identify autoimmune hepatitis (AIH)-specific autoantibodies using a high-content human protein microarray and evaluate their diagnostic performance. Pretreatment sera from untreated patients with AIH (n = 68), primary biliary cholangitis (PBC, n = 19), metabolic dysfunction-associated steatotic liver disease (MASLD, n = 39), chronic hepatitis C (CHC, n = 27), and drug-induced liver injury (DILI, n = 18) and healthy controls (HC, n = 37) were screened with a wheat-germ, cell-free microarray displaying > 16,000 proteins. Candidate antigens were validated by ELISA, and antibody titers were correlated with clinical variables, treatment response, and outcomes. Mitochondrial ribosomal protein S27 (MRPS27) emerged as the dominant AIH-associated antigen. The mean anti-MRPS27 antibody titer in untreated patients with AIH (50.2 AU) exceeded that in patients with PBC (9.3 AU), MASLD (12.8 AU), CHC (24.8 AU), DILI (19.8 AU), and HC (7.5 AU, all p < 0.01). A cutoff of 35.4 AU (HC mean + 2 SD) yielded a sensitivity of 61.8%, a specificity of 87.1%, a positive predictive value of 70.0%, and a negative predictive value of 82.4%. Positivity was unrelated to baseline histology, biochemistry or IgG, and titers were unchanged after corticosteroid induction. Interestingly, patients with low titers experienced more liver-related events during follow-up. The anti-MRPS27 antibody is a promising adjunctive serological marker that enhances the specificity of AIH diagnosis. The pathogenic significance and prognostic value of this antibody warrant prospective validation.

#2

Geographic distribution and demographic patterns of primary biliary cholangitis and autoimmune hepatitis in Colombia: a national population-based administrative study (2018-2024).

Annals of gastroenterology2026

Autoimmune liver diseases, including primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), are rare chronic conditions with significant morbidity. However, population-based epidemiological data from Latin America remain limited. This study aimed to describe the geographic distribution and demographic patterns of PBC and AIH in Colombia between 2018 and 2024. A descriptive, cross-sectional population-based study was conducted using data from the Comprehensive Social Protection Information System (SISPRO) of the Colombian Ministry of Health. Individuals with at least 1 recorded diagnosis coded as K74.3 (PBC) or K75.4 (AIH) according to the International Classification of Diseases, 10th Revision (ICD-10), were identified. Administrative prevalence estimates were calculated per 100,000 population, using official population projections from the National Administrative Department of Statistics (DANE). Age- and sex-specific distributions were analyzed, and geographic variation was visualized using choropleth maps at the regional level. A total of 6504 PBC cases and 11,225 AIH cases were identified. The estimated national administrative prevalence was 14.7 per 100,000 population for PBC and 17.0 per 100,000 for AIH. Both conditions showed marked female predominance. PBC was more frequent in women aged 50-69 years. However, AIH demonstrated a broader age distribution, affecting individuals from young adulthood to older age. Higher prevalence estimates were observed in multiple northern regions, particularly in the Caribbean region. This first nationwide administrative assessment of PBC and AIH in Colombia demonstrates marked sex differences and regional variation, highlighting the need to improve diagnostic awareness and strengthen epidemiological surveillance of autoimmune liver diseases in Latin America.

#3

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.

Journal of hepatology2026 Mar 19

Autoimmune hepatitis (AIH) patients experience increased mortality and severe side effects from non-specific immunosuppressive therapy, highlighting an urgent need for targeted treatment approaches. Here, we aimed to delineate the cellular and molecular network underlying AIH within its spatial context and to validate a key therapeutic target in a clinical trial. We employed computational modelling, multi-omics analyses, and functional experiments to map the immune landscape of AIH. In addition, we conducted a steroid-free open-label phase IIa clinical trial using infliximab, a TNF-targeting antibody, in AIH patients. Our studies revealed that myeloid cell and hepatocyte-derived IL-15 promotes cytotoxicity and proliferation of liver auto-aggressive CD8+ T cells. Full execution of their cytotoxic program is licensed by TNF derived from clonally expanded liver-resident CD4+ T cells. AIH hepatocytes respond to TNF by increasing expression of adhesion molecules making them targets for both CD8+ and CD4+ T cells. In the clinical trial, targeting TNF with infliximab demonstrated efficacy as an entirely steroid-free AIH treatment. These findings elucidate the immune network in AIH and identify TNF as one of the central network nodes. Accordingly, our findings provide the basis for novel targeted, steroid-free immune therapies such as the use of infliximab. These findings have significant implications for the treatment of autoimmune hepatitis. By mapping the spatial and functional immune network within the AIH liver, this study identifies IL-15 and TNF as central drivers of T cell-mediated cytotoxicity, offering new precision targets for intervention. The successful use of infliximab as a steroid-free therapy in a phase II trial marks a pivotal step toward safer, more specific treatment options for AIH patients. This research not only advances our understanding of AIH pathogenesis, but also sets the stage for broader application of immune-targeted therapies in autoimmune liver diseases.

#4

Association between serum uric acid and non-alcoholic fatty liver disease (NAFLD): an observational cross-sectional study in an Egyptian outpatient cohort.

BMC gastroenterology2026 Mar 19

Hepatic steatosis, characterized by excessive triglyceride accumulation within hepatocytes, is the central feature of non-alcoholic fatty liver disease (NAFLD). This spectrum encompasses simple steatosis, non-alcoholic steatohepatitis (NASH), progressive fibrosis, and cirrhosis. NAFLD pathogenesis involves an intricate interplay between nutritional factors, metabolic dysregulation, and genetic predisposition. Evidence suggests hyperuricemia is an independent risk factor for NAFLD, with elevated serum uric acid (SUA) levels associated with increased steatosis severity and fibrosis advancement. This study investigated the association between SUA levels and liver involvement—specifically ultrasound-assessed steatosis grading and elastography-measured liver stiffness—in patients with NAFLD. This cross-sectional study enrolled 70 patients aged ≥18 years with ultrasound-diagnosed NAFLD (Group I) and 70 age-, sex-, and residence-matched healthy controls (Group II). Participants were recruited from Minia University Liver Hospital between March 2022 and February 2023. Exclusion criteria included excessive alcohol consumption, viral or autoimmune hepatitis, established cirrhosis, and medications affecting uric acid metabolism. The primary outcome was presence of NAFLD. Evaluations comprised detailed medical history, anthropometric measurements, laboratory testing (including SUA), abdominal ultrasonography for steatosis grading, and two-dimensional shear wave elastography for liver stiffness assessment. Hyperuricemia prevalence reached 55.7% (n=39) among NAFLD patients compared to 0% in controls (p=0.001). Mean SUA concentrations were significantly elevated in the NAFLD group versus controls (5.98 ± 1.9 mg/dL vs. 4.34 ± 0.7 mg/dL, p=0.001). A significant association emerged between hyperuricemia and hepatic steatosis grades (p=0.032). Multivariate logistic regression identified SUA as independently associated with NAFLD after adjustment for confounders (Adjusted OR 1.45; 95% CI: 1.12–1.88, p=0.005 per 1 mg/dL increment), alongside BMI, waist circumference, triglycerides, and creatinine. Receiver operating characteristic (ROC) analysis demonstrated an optimal 5.3 mg/dL SUA cut-off for NAFLD discrimination (AUC 0.74, 64% sensitivity, 94% specificity, p=0.001). Elevated SUA levels were consistently associated with NAFLD presence, steatosis severity, and increased liver stiffness. The 5.3 mg/dL threshold warrants further validation. Notable limitations include single-center recruitment potentially limiting generalizability, a cross-sectional design precluding temporal relationship and causality determination, and the possibility of residual confounding from unmeasured variables. The online version contains supplementary material available at 10.1186/s12876-026-04655-2.

#5

Autoimmune Hepatitis Unmasked by Acute Viral Hepatitis: A Diagnostic and Therapeutic Challenge.

Journal of clinical and experimental hepatology2026

Autoimmune hepatitis (AIH) is a rare disease with unclear pathogenesis. Acute viral hepatitis (AVH) can trigger autoimmunity and unmask underlying AIH, which can be difficult to recognize due to overlapping clinical features. This case series included 10 patients diagnosed with AIH following confirmed AVH. Demographics, clinical presentation, investigations, biopsy results, and treatment outcomes were analyzed. Diagnosis of AIH was established using the simplified AIH score. The cohort included seven patients with hepatitis A virus, two with hepatitis E virus, and one with hepatitis B virus. Mean age was 26.9 ± 10.6 years with male predominance (n = 7,70%). Median time to AIH diagnosis was 82 (68-125) days after initial symptoms. Serum immunoglobulin G was elevated in all patients [median: 1834.5(1138-3858 mg/dL); normal <1700 mg/dL]. Anti-nuclear antibody was positive in 40%, anti-smooth muscle antibody in 30%, with 40% being seronegative. Liver biopsies showed interface hepatitis (90%), lobular inflammation (100%), and lymphoplasmacytic infiltrate (100%). Fibrosis (Metavir scoring system) stages were F0 (30%), F1 (20%), F2 (30%), and F3 (20%). All patients achieved complete biochemical remission with prednisolone (dose: 0.5-1 mg/kg/day, and azathioprine (dose: 1-2 mg/kg/day, median initiation time: 45 days after prednisolone start). One attempt at immunosuppression withdrawal resulted in flare. AVH can unmask underlying AIH and protracted course beyond the expected course of AVH for prompt evaluation of AIH. Standard immunosuppressive therapy is generally effective and long-term maintenance treatment may be required.

Publicações recentes

When to Consider AIH-PBC OverlapSyndrome in the Pathology Report.

Am J Surg Pathol2026 Apr 15

[A non-invasive diagnostic evaluation study on liver fibrosis in children with autoimmune hepatitis].

Zhonghua Er Ke Za Zhi2026 Apr 16

Specific Therapies For ALF: Viral, Autoimmune and Wilson Disease.

J Intensive Care Med2026 Apr 15

The role of Traditional Chinese Medicine in the management of liver disease: targeting gut microbiome.

Chin Med2026 Apr 14

Use of Machine Learning in Predicting the Risk of Cirrhosis in Autoimmune Hepatitis Based on Clinical and Immunological Indicators.

Diagnostics (Basel)2026 Mar 25

Ver todas no PubMed

📚 EuropePMC4.581 artigos no totalmostrando 193

Oxford medical case reports

Cholestatic liver disease in an adolescent: don't forget progressive familial intrahepatic Cholestasis-8.

Research progress on the role of gut microbiota dysbiosis in the pathogenesis of immune-mediated liver diseases.

Hepatology research : the official journal of the Japan Society of Hepatology

Anti-MRPS27 Antibody: A Novel Diagnostic Biomarker for Autoimmune Hepatitis Identified via a Human Proteome Microarray.

Meta-Analysis: PPAR Agonists for Pruritus and Quality of Life in Primary Biliary Cholangitis.

Annals of gastroenterology

Geographic distribution and demographic patterns of primary biliary cholangitis and autoimmune hepatitis in Colombia: a national population-based administrative study (2018-2024).

Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitis.

Journal of hepatology

Journal of clinical immunology

Fostamatinib Dual Immunomodulation in Post-Haploidentical HSCT Autoimmune Cytopenia and Autoimmune Hepatitis: A Case Report and Review of Literature.

Association between serum uric acid and non-alcoholic fatty liver disease (NAFLD): an observational cross-sectional study in an Egyptian outpatient cohort.

BMC gastroenterology

Autoimmune Hepatitis Unmasked by Acute Viral Hepatitis: A Diagnostic and Therapeutic Challenge.

International immunopharmacology

Naringin alleviates autoimmune hepatitis in mice via the gut-liver Axis through modulation of microbiota, metabolites, and immune responses.

Dual Positivity for AMA/AMA-M2 and Anti-gp210/sp100 Shows Highest Diagnostic Value for Primary Biliary Cholangitis.

Journal of pediatric gastroenterology and nutrition

Transient elastography for accurate staging of liver fibrosis and predicting complications in children with autoimmune hepatitis.

Journal of medical case reports

Late-onset combined immunodeficiency and bone marrow failure in severe autoimmune hepatitis: a case report.

In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis.

Cell stem cell

Anti-Inflammatory Effects of Goat Whey Protein in Concanavalin-A Induced Hepatitis.

Nutrients

Mast Cells at the Crossroad of Gut-Derived Signals Through Aryl Hydrocarbon Receptor Activation: A Microbial-Immune Dialogue in Liver Inflammation with Therapeutic Perspectives.

Cells

Autoimmune Hepatitis: A Review of Molecular Mechanisms and Research Gaps in African Populations.

Biology

The Journal of the Association of Physicians of India

Autoimmune Hepatitis and Pregnancy: A Case Report.

Naunyn-Schmiedeberg's archives of pharmacology

Constructing a protein-protein interaction network for autoimmune liver diseases by integrating pQTL, rQTL, and mediation analyses.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[Infliximab-induced autoimmune-like hepatitis developed during treatment for Crohn's disease:a case report].

Assessing the associations between immunosuppressant use and COVID-19 severity in patients with autoimmune hepatitis.

Characterization of CD24+ T Cells and Their Cytokine Signature in Autoimmune Hepatitis.

Tumor Necrosis Factor-Alpha (TNF-α) Inhibitor Treatment in Hidradenitis Suppurativa: A Population-Based Retrospective Cohort Study of Comorbid Risks.

Clinical and experimental immunology

An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis.

Drug-induced autoimmune hepatitis due to atorvastatin: a complex clinical case and literature review.

Gastroenterology report

Liver international : official journal of the International Association for the Study of the Liver

Elevated Polyreactive Immunoglobulin G in Immune-Mediated Liver Injuries With the Need for Immunosuppressive Therapy.

Can liver biopsy be spared for the diagnosis of autoimmune hepatitis in selected children? A multicenter retrospective study.

Annals of hepatology

Transplant infectious disease : an official journal of the Transplantation Society

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

Prevalence, clinical features, and laboratory predictors of autoimmune hepatitis in systemic sclerosis: A retrospective single-center cohort study.

Clinical rheumatology

Cellular and molecular gastroenterology and hepatology

Ubiquitin-Conjugating Enzyme E2O Primes Hepatocytes to Restore Immune Tolerance in Autoimmune Hepatitis via Inhibiting Y-Box Binding Protein 1/Interleukin-6 Axis.

Indian National Association for Study of the Liver Guidance Document on Difficult to Treat Autoimmune Hepatitis.

The Journal of experimental medicine

Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens.

Nlrp12-driven PANoptosis exacerbates liver injury in ConA-induced autoimmune hepatitis.

Genes and immunity

Clinical nuclear medicine

Sjögren Syndrome Associated Limbic Encephalitis and Its Longitudinal Brain FDG PET Manifestations.

Acquired bisalbuminemia associated with hepatobiliary disease: a two-case report and diagnostic implications.

Laboratory medicine

Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC.

JGH open : an open access journal of gastroenterology and hepatology

Dosing and Route of Steroid Induction Therapy in Non-Severe Autoimmune Hepatitis Do Not Affect Time to Biochemical Response.

Unmasking Parasitic Colitis Mimicking Inflammatory Bowel Disease.

Genotype-Phenotype Delineation of Autoimmune Polyendocrinopathy, Candidiasis, and Ectodermal Dystrophy in a Pediatric Patient: A Case Report.

Genes

Clinics and research in hepatology and gastroenterology

How do oral pathogenic bacteria potentially contribute to inflammatory processes in autoimmune liver disease? Results from a systematic review.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis.

Azathioprine-Associated Acute Pancreatitis Followed by a Probable Autoimmune Hepatitis Flare After Thiopurine Withdrawal: A Case Report.

Isolated IgG elevation in patients with persistently normal transaminases does not affect the outcome of autoimmune hepatitis: or just a little bit?

Regulatory T-cells in autoimmune hepatitis: An historical perspective with hints to the future.

Deciphering the potential molecular mechanism of resmetirom in idiosyncratic drug- induced autoimmune hepatitis using network toxicology and molecular docking.

In silico pharmacology

CX3CL1/CX3CR1 axis in liver disease: context-dependent roles and balance.

The journal of allergy and clinical immunology. In practice

Hepatic Manifestations of STAT1 Gain-of-Function Variants.

Journal of epidemiology and global health

Clinical Characteristics of Chronic Pancreatitis in a Saudi Arabian Population: A Retrospective Cohort Study at Riyadh Second Health Cluster.

Kikuchi Disease Unveiling Systemic Lupus Erythematosus: A Rare Case of Initial Manifestation.

Oman medical journal

World journal of clinical cases

Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions.

Letter on 'Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis': Authors' Reply.

Azathioprine-induced acute generalized exanthematous pustulosis in a woman with autoimmune hepatitis.

Dermatology reports

A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease.

JPGN reports

A case of autoimmune hepatitis in a patient with inflammatory bowel disease and significant lymphadenopathy in the porta hepatis.

JPGN reports

Case Report: IL2RA (CD25) deficiency: first reported cases in Morocco.

NON-INVASIVE QUANTITATIVE CT PERFUSION OF THE LIVER IN AUTOIMMUNE HEPATITIS.

Georgian medical news

International journal of molecular sciences

Liver Disease in Common Variable Immunodeficiency: Current Evidence and Knowledge Gaps.

International journal of molecular sciences

Primary Biliary Cholangitis Pathogenesis: A Pathophysiology-Based Narrative Review.

Journal of translational autoimmunity

Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies.

Pulmonary aspergillosis diagnosed during surgical treatment for spontaneous pneumothorax: a case report.

AME case reports

Translational gastroenterology and hepatology

Primary sclerosing cholangitis in children: a single-center experience and evaluation of prognostic markers.

Clinical reviews in allergy & immunology

The Geoepidemiology of Autoimmune Hepatitis.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Evaluation of Histological Criteria and Immunoserological Testing of Simplified Criteria for the Diagnosis of Autoimmune Hepatitis.

Journal of clinical and translational hepatology

Extrahepatic Autoimmune Diseases in Autoimmune Hepatitis: Their Prevalence, Predictors, and Influence on Early Treatment Outcomes.

Association between type 2 diabetes and autoimmune liver disease: An integrated analysis of Mendelian randomization and clinical samples.

Association between osteoporosis and waitlist mortality in liver transplant candidates.

Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction.

Strengthening the stratification of autoimmune hepatitis: toward enhanced clinical applicability.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Autoimmune hepatitis overlap syndrome: Clinical presentation, treatment response, and disease evolution: Tertiary centre experience.

Clinical and Demographic Profile of Wilson Disease in Young Adults: A Retrospective Study at a Tertiary Care Center in Peshawar, Pakistan.

A Mysterious Case of Autoimmune Hepatitis Triggered by Herpes Zoster Virus Versus Drug-Induced Liver Injury.

Journal of advanced research

Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[A case of toxic shock syndrome secondary to severe bone marrow suppression induced by azathioprine in a patient with autoimmune hepatitis].

Refining the definition of acute autoimmune hepatitis: implications for classification and prognosis.

An Association Between Autoimmune Hepatitis (AIH) and Immunoglobulin G4-Related Disease (IgG4-RD) in a Male Diagnosed With Primary Sjögren's Syndrome (SJS): A Case-Based Review.

Complementary use of autoantibody detection methods facilitates diagnosis of juvenile autoimmune hepatitis and autoimmune sclerosing cholangitis.

Extending the Baveno VII definition of recompensation to autoimmune hepatitis: Considerations regarding treatment timing and response criteria.

Liver international : official journal of the International Association for the Study of the Liver

Quality of Life in Patients With Variant Syndromes of Autoimmune Liver Diseases-A Cross-Sectional Multicentre Study.

Simvastatin Alleviates ConA-Induced Autoimmune Hepatitis by Inhibiting CD4+ T Cell Activation via Calcium-NFATC3 Pathway.

Inflammation

European journal of gastroenterology & hepatology

Clinical course and prognostic risk factors of SARS-CoV-2 vaccine-related hepatitis: differentiating severe acute respiratory syndrome coronavirus 2 vaccine-associated liver injury from autoimmune hepatitis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cleavage-Resistant CYLD Protects Against Autoimmune Hepatitis.

Clinical characteristics and outcomes in 50 children with autoimmune hepatitis: a retrospective study from a single centre in China.

Frontiers in medicine

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

6-Mercaptopurine vs Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study.

Association between thyroid diseases and autoimmune hepatitis: A bidirectional Mendelian randomization study.

European journal of medical research

COLEC10 and COLEC11 are new serum biomarkers of chronic liver disease.

Scandinavian journal of rheumatology

Organ-specific autoimmunity in primary Sjögren's disease.

Shaping the Profile of Liver Transplantation for Autoimmune Hepatitis in North and Northeastern Brazil.

Transplantation

Autoimmune Hepatitis Presenting With Severe Pruritus in a 27-Year-Old Male.

The Great Imitator: Syphilitic Hepatitis Presenting as a Mimic to Autoimmune Liver Disease.

Military medicine

Clinics and research in hepatology and gastroenterology

Sensitivity and specificity of magnetic resonance elastography in liver diseases in the pediatric age group.

Massive hepatic necrosis-associated acute liver failure.

eGastroenterology

Immunoglobulin G4-related disease with multi-organ involvement: A case report.

Efavirenz-Induced Hepatitis Mimicking Autoimmune Hepatitis: A Case Report.

Inhibition of estrogen receptor alpha stabilizes regulatory T cell function in autoimmune hepatitis.

Archives of pathology & laboratory medicine

Liver Biopsy Features May Help Distinguish Drug-Induced Autoimmune-Like Hepatitis From Idiopathic Autoimmune Hepatitis.

Case reports in hepatology

DPMAS in the Management of Severe Acute Liver Injury.

The American journal of gastroenterology

Autoimmune Hepatitis and Depression.

Annexin A5 ameliorates immune-mediated liver injury by regulating ferritinophagy-ferroptosis in M2 macrophages via the NRF2/ERK pathway.

Cellular signalling

Severe autoimmune hepatitis and necrotising pancreatitis following ofatumumab in a patient with multiple sclerosis.

BMJ case reports

Dysgeusia-Driven Nutritional Decline in Cirrhosis: A Case of Autoimmune Hepatitis and Primary Biliary Cholangitis.

Journal of clinical medicine

Inferior Vena Cava-Atrial Anastomosis in Liver Transplant Recipient with Inferior Vena Cava Occlusion: A Case Report and Literature Review.

International journal of molecular sciences

Increased Intrahepatic Mast Cell Density in Liver Cirrhosis Due to MASLD and Other Non-Infectious Chronic Liver Diseases.

MAIT Cells in Liver Disease.

Cells

Intrahepatic Lymphedema Presenting With Abnormal Bilirubin Metabolism as the Initial Manifestation.

ACG case reports journal

[A case of recurrent hypoglycemic coma episodes associated with primary biliary cholangitis and literature review].

Zhonghua nei ke za zhi

CNS neuroscience & therapeutics

Depression Aggravates Immune-Mediated Hepatitis Through NLRP3 Overactivation Induced by Intestinal Microbiota.

Retrospective, single-center analysis of autoimmune hepatitis in Yemeni adults: clinical features, treatment, and outcomes.

BMC immunology

Elevated neutrophil-to-lymphocyte ratio and the incidence of autoimmune diseases: evidence from a large prospective cohort study.

Current opinion in gastroenterology

Management of autoimmune hepatitis-related decompensated cirrhosis: current evidence and clinical decision-making.

Journal of gastroenterology and hepatology

IgG4-Associated Autoimmune Hepatitis: a Systematic Review.

Journal of medicinal chemistry

Discovery of Novel Nonsteroidal SGRMs of Sulfonamide-2-Oxo-Tetrahydroquinoline Derivatives by Carbonyl Migration.

Genuine acute autoimmune hepatitis has better therapeutic response and prognosis.

Management of Severe Abemaciclib-induced Liver Dysfunction: Feasibility of Switching to Palbociclib.

In vivo (Athens, Greece)

World journal of gastrointestinal pathophysiology

Gluten's silent strike: Unmasking its impact on liver health.

Drug-induced liver injury in inflammatory bowel disease: Challenges in diagnosis and monitoring.

Refractory autoimmune hepatitis in children: Considerations for assessment and management.

Impact of age on autoimmune hepatitis: A comparative study of patients diagnosed before and after sixty.

Journal of translational autoimmunity

Cell-specific epigenome-wide DNA methylation in peripheral CD4(+) lymphocytes from patients with primary biliary cholangitis.

Pathogens (Basel, Switzerland)

Autoimmune Hepatitis After Successful Treatment of Chronic Hepatitis C Virus Infection with Direct-Acting Antivirals: A Pediatric Case Report.

Rare Lupus Exacerbation Shines Light on Provider Bias in a Patient With Possible Autoimmune Hepatitis.

Journal of clinical medicine

Wilson's Disease with Autoimmune Hepatitis Manifestation in a Pediatric Patient: A Case Report and Literature Review.

Liver Innervation in Health and Disease: Neuroimmune-Neurovascular Interface and Future Therapeutic Implications.

Biomedicines

Clinical characteristics and factors associated with liver stiffness in patients with autoimmune liver disease: a cross-sectional study from the Kashgar region.

BMC gastroenterology

Oxford medical case reports

Graves' disease with autoimmune hepatitis and primary Sclerosing cholangitis: an overlap syndrome.

Boletin medico del Hospital Infantil de Mexico

Acute hepatitis secondary to Mycoplasma pneumoniae infection.

Pediatric autoimmune hepatitis in the Asia-Pacific region: practical considerations for guideline implementation.

Severe Hepatitis in a Patient With Undifferentiated Connective Tissue Disease: Diagnostic Uncertainty Between Methotrexate Toxicity and Autoimmune Liver Involvement.

Hepatocyte guardian: A20 restrains ferroptosis in autoimmune hepatitis.

Gut

Acute Severe Autoimmune Hepatitis With Superimposed Scrub Typhus: An Uncommon Cause of Subacute Hepatic Failure Identified in Autopsy.

Current opinion in gastroenterology

PBC-AIH variant syndrome: emerging new terminology and a new approach to diagnosis and management.

Experimental & molecular medicine

Bone marrow-derived CD169+ macrophages promote autoimmune hepatitis by recruiting CCR2+ monocytes via secreting CCL12.

Liver international : official journal of the International Association for the Study of the Liver

A Novel BAFF/APRIL Dual Inhibitor in Treating Refractory Autoimmune Hepatitis.

Expert review of gastroenterology & hepatology

The pediatric medical liver biopsy: indications, procedures, and histopathology.

Hepatology research : the official journal of the Japan Society of Hepatology

Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications.

Clinics and research in hepatology and gastroenterology

Prevalence and risk factors of portopulmonary hypertension in chronic liver disease: systematic review and meta-analysis.

Left-Sided Diaphragmatic Hernia Following Pediatric Liver Transplantation: First Reported Case From the Middle East.

RIPK1 inhibition reduces biliary injury and fibrosis in primary sclerosing cholangitis.

Science advances

Transplantation reviews (Orlando, Fla.)

Global epidemiology and determinants of autoimmune hepatitis recurrence post- liver transplantation: A systematic review and meta-analysis.

Boletin medico del Hospital Infantil de Mexico

Pediatric consensus of autoimmune hepatitis.

American journal of hematology

Autoimmune Features in Sickle Cell Patients: A New Explanation for Liver Damage?

Conversion from veno-arterial to veno-pulmonary ECMO for refractory pulmonary hypertension and right ventricular failure after orthotopic liver transplantation.

BMJ case reports

Idiosyncratic Warfarin-Induced Hepatocellular Injury: A Reversible and Uncommon Occurrence.

Challenges in the Diagnosis of Autoimmune Hepatitis in Patients With Chronic Viral Hepatitis C: A Case Series and Review of the Literature.

Hepatology communications

Autoimmune liver diseases in Latin America: Current landscape and challenges.

BMJ open gastroenterology

Pruritus and health-related quality of life in chronic liver disease: a longitudinal, survey-based cohort study.

Annals of medicine and surgery (2012)

The detrimental effect of autoimmune hepatitis in pregnancy: a systematic review and meta-analysis.

Healthcare (Basel, Switzerland)

From Isolation to Information: Launching an Online Community for Patients with Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, and Autoimmune Hepatitis in Romania-A Descriptive Study.

Beyond bones: Revisiting the role of vitamin D in chronic liver disease.

Autoimmune-like hepatitis induced by drugs: Still many unanswered questions.

Unveiling the Spectrum of Liver Endurance in Systemic Lupus Erythematosus: A Single-Center Experience From Kashmir, India.

Expanded but dysfunctional regulatory T cells in treatment-naïve autoimmune hepatitis.

Discrepancy between international guidelines and global laboratory practices in autoantibody testing for autoimmune hepatitis.

Autoimmunity reviews

World journal of transplantation

Risk factors for autoimmune liver disease recurrence after liver transplantation.

Triple autoimmune overlap syndrome of the liver: a rare case of concomitant PBC, PSC, and AIH.

Future science OA

Genome-annotated bivariate analysis of shared heritability in autoimmune hepatitis with psychiatric comorbidity.

The Journal of experimental medicine

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.

Decoding the distinct immune landscape and possible regulatory mechanisms of autoimmune hepatitis through integrated single-cell and bulk RNA sequencing.

PloS one

Human umbilical cord-derived mesenchymal stem cells alleviate autoimmune hepatitis by inhibiting hepatic ferroptosis.

PloS one

Coagulation abnormalities in children with chronic liver disease and the association of these abnormalities with disease severity.

iLIVER

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Alfuzosin-Induced Autoimmune Hepatitis: A Rare Case Report.

Journal of clinical tuberculosis and other mycobacterial diseases

Latent TB treatment outcomes in patients with chronic liver disease: A retrospective cohort study.

Association between ABO blood group system and autoimmune liver disease.

Frontiers in medicine

The pivotal role of cytokines in liver disease pathogenesis and therapeutic potential.

Unraveling the Complexity: A Case of Systemic Lupus Erythematosus, Warm Autoimmune Hemolytic Anemia, and Autoimmune Cholangitis.

Autoimmune liver diseases in the Asia Pacific region: proceedings of the autoimmune liver disease course at APASL 2025.

American journal of physiology. Gastrointestinal and liver physiology

Neutrophil-T cell cross talk in noninfectious liver diseases.

From thrombosis to transplantation: The role of anti-phospholipid antibodies in liver disease management.

iLIVER

AMA-Negative Primary Biliary Cholangitis and Autoimmune Hepatitis Overlap Syndrome Presenting With Bullous Pemphigoid: A Case Report.

Clinical case reports

Hepatology research : the official journal of the Japan Society of Hepatology

Autoimmune Hepatitis Profiles After Liver Transplantation in Latin American Patients: A Cluster Analysis of Clinical Outcomes.

Beyond biochemical remission: roadmap for integrating health-related quality of life into autoimmune hepatitis management and research.

An association between antibiotic usage during pregnancy and the subsequent development of autoimmune hepatitis.

Canadian liver journal

Oxford medical case reports

Hypereosinophilic syndrome with pulmonary and hepatic involvement mimicking autoimmune disease.

Acta pharmaceutica Sinica. B

DNAzyme targeting RIP3 suppresses NLRP3-mediated necroinflammation for the treatment of inflammatory diseases.

Journal of clinical and translational hepatology

Immunoglobulin G4-related Autoimmune Hepatitis: Diagnosis and Treatment.

Clinical and pathological features of antinuclear antibody-positive drug-induced liver injury compared with autoimmune hepatitis: A retrospective study.

Gut microbiota-derived metabolites modulate Treg/Th17 balance: novel therapeutic targets in autoimmune diseases.

Journal of medical case reports

Management of refractory autoimmune hepatitis with rituximab: a case series.

Peiminine modulates T cell-associated gene expression and inflammatory activity in experimental autoimmune hepatitis.

Cellular immunology

Letter on 'Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis'.

Pulse Granuloma-Like Lesion of the Portal Vein in a Liver Explant: A Case Supporting the Endogenous Theory.

Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development.

JGH open : an open access journal of gastroenterology and hepatology

Diagnostic Utility of Liver Biopsy in Persistent Unexplained Liver Enzyme Elevation: A Retrospective Cohort Study.

ABCB4 disease-causing variants S242R, S346I, T437I and T1077M significantly impair its function and display differential sensitivity to potentiators.

Chronic drug-induced liver injury in a child with acute lymphoblastic leukemia: a case report.

BMC pediatrics

Systemic PCSK9 elevation characterises autoimmune liver disease across sexes.

Clinical medicine (London, England)

An overview of paediatric autoimmune and genetic cholestatic liver disease for the adult physician.

Autoimmune hepatitis in children: Guidelines of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).

Metabolomics in autoimmune hepatitis: progress and perspectives.

Frontiers in medicine

The American journal of gastroenterology

The risk of psychiatric disorders in patients with autoimmune hepatitis: a nationwide registry-based follow-up study.

Journal of the European Academy of Dermatology and Venereology : JEADV

The risk and prevalence of hepatic diseases in psoriasis: A systematic review and meta-analysis.

Simultaneous degenerative changes in 2 hepatic cavernous hemangiomas observed over 23 years of follow-up: A case report and review of the literature.

Radiology case reports

Digestive autoimmune diseases mimicking gastrointestinal manifestations in children with sickle cell anemia: A report of three cases.

JPGN reports

Ver todos os 4.581 no EuropePMC

Hepatobiliary Adverse Events Linked to Immune Checkpoint Inhibitors: A Real-World Pharmacovigilance Analysis Using FAERS Data.

Thoracic cancer

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Próxima:Doenças relacionadas

Doenças relacionadas

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Ordenadas pelo número de sintomas em comum.

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ORPHA:562639

Colangite esclerosante

17 em comum

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Colestase intra-hepática familiar

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Alteração do metabolismo e excreção de bilirrubina

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Lúpus eritematoso sistêmico

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