Melanocitoma meníngeo

Clinical, Radiological, Histologic and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System

NCT05984108

DESCONHECIDO

Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors

NCT02194452

DESCONHECIDO

Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer

NCT00492089

CONCLUÍDO

Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors

NCT00110032

DESCONHECIDO

Pesquisa e ensaios clínicos

10 ensaios clínicos encontrados.

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NCT05984108 · Clinical, Radiological, Histologic and Molecular Features of…UNKNOWN

NCT02194452 · Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) …Cancelado

NA

NCT00492089 · Bevacizumab in Reducing CNS Side Effects in Patients Who Hav…Concluído

PHASE2

NCT00110032 · Positron Emission Tomography Using Fluorine F 18 EF5 to Find…Encerrado

PHASE1

Ver todos no ClinicalTrials.gov

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Timeline de publicações

73 papers (10 anos)

#1

Meningeal Melanocytoma of the Lumbar Spinal Region: A Unique and Unusual Presentation.

International journal of surgical pathology2026 Jan 23

Meningeal melanocytoma of the central nervous system is a rare primary melanocytic neoplasm arising from the leptomeninges' melanocytes. It chiefly occurs in the posterior cranial fossa and rarely involves the spinal cord. The literature is bereft of lumbar spinal involvement by meningeal melanocytomas. Herein, we present a 17-year-old male patient who was incidentally diagnosed with a lumbar spinal meningeal melanocytoma during an imaging workup for backache following a fall. It was an extramedullary intradural tumor and was amenable to complete surgical removal in the spinal region. This case report highlights the importance of keeping the possibility of meningeal melanocytoma as a differential diagnosis of circumscribed intradural extramedullary neoplasms.

#2

Cerebellopontine Angle Meningeal Melanocytoma: A Rare Case and Literature Review of Outcomes and Recurrences.

Neurology India2025 Jul 01

Melanocytes are neural crest derived cells. Intracranial meningeal melanocytomas (MM) are rare tumors that were first described in 1972. Authors report a rare case of a cerebellopontine (CP) angle MM. In addition, a literature review of CP angle MM is provided and compared with other cranial MMs in terms of recurrence and outcomes. A 45 year old male presented with tinnitus and occipital headache. He had mild sensorineural hearing loss. MRI showed an extra axial CP angle lesion that was hyperintense on T1 and hypointense on T2, with blooming on SWI sequences. A retrosigmoid craniotomy and near total resection was performed. Postoperatively, he developed paresis of the facial and lower cranial nerves, hemiparesis, developed pulmonary complications and died 3 months later. A total of 20 cases of CP angle MM were retrieved and analysed from literature. We noted significant differences between the overall cranial MM and CP angle MM in terms of recurrence and malignant transformation. The recurrence rate was 60%, the higher grade transformation rate was 10%, and mortality was 18%, which was higher than that of cranial MM in general. Authors believe that upfront adjuvant radiotherapy may possibly reduce the recurrence rates in this location.

#3

Aggressive Clinical Course and Malignant Transformation of a Meningeal Melanocytoma of the Pontomedullary Region: Diagnostic and Therapeutic Implications.

Journal of neurological surgery reports2025 Oct

Primary melanocytic tumors of the central nervous system (CNS) are rare neoplasms that range from benign melanocytomas to aggressive malignant melanomas. Although meningeal melanocytomas are generally considered indolent lesions, malignant transformation and distant metastasis can occur. We report the case of a 33-year-old male with a bulbopontine meningeal melanocytoma who developed systemic metastases, culminating in a fatal outcome. Despite initial histopathologic features of benignity and absence of BRAF mutation, the lesion showed aggressive behavior. This case underscores the diagnostic pitfalls associated with primary CNS melanocytic tumors and highlights the importance of long-term vigilance, even for histologically benign lesions.

#4

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma.

Journal of neuro-oncology2025 Dec 01

Spinal melanocytic tumors are rare, with limited data on their clinical course and aggressiveness. Since intraoperative dark pigmentation and infiltrative margins can lead to misclassification of MC as MM-especially in the absence of a known primary-this multicenter study characterizes melanocytomas (MC) and contrasts them with malignant melanoma (MM). We retrospectively analyzed 56 patients with spinal intradural melanocytic tumors (2010-2024) from seven European neurosurgical centers. Clinical, radiological, histological, and surgical features were analyzed. Univariate and multivariate analyses were performed to identify prognostic risk factors. The study included 22 patients with spinal MC and 34 patients with MM. Median age was comparable (61 vs. 58 years, p = 0.09), but MC patients had a longer symptom history (13 vs. 1.3 months, p = 0.0001) and more often intramedullary tumors (72.7% vs. 2.9%, p < 0.0001). Gross total resection was achieved in 40.9% of MC cases and 61.8% of MM cases (p = 0.07), with instrumentation required more often for MM (p = 0.0022). Ki-67 proliferation index was significantly higher in MM than MC (26.7% vs. 6.6%, p < 0.0001). Postoperative deficits were more frequent in MC (54.6% vs. 14.7%, p = 0.002) and MCs showed higher frequency of ataxia postoperatively (36.4% vs. 11.8%, p = 0.04). MM patients received more adjuvant therapy (88.2% vs. 31.8%, p = 0.0001), with a trend toward higher local recurrence (26.5% vs. 14.7%, p = 0.31). Our study demonstrates that MC, though considered benign, carries a high risk of postoperative deficits. Furthermore, GTR was achieved in only 40% of cases, underscoring its locally infiltrative nature and potential for semi-benign biology.

#5

Primary Intracranial Meningeal Melanocytoma with Malignant Transformation: A Case Report and Comparison of Early Versus Late Immunotherapy Interventions.

Current oncology (Toronto, Ont.)2025 Oct 24

Primary meningeal melanocytoma is an uncommon, pigmented neoplasm that rarely undergoes malignant transformation, and therapeutic guidelines remain undefined. We report a 43-year-old woman who initially presented with a sudden headache and a right temporal intraparenchymal mass. Subtotal resection revealed a melanocytoma (WHO grade I); residual tumor was treated with Gamma Knife. About 15 months later, she deteriorated rapidly due to malignant transformation with cerebral hemorrhage and spinal leptomeningeal metastasis. Pembrolizumab was initiated within four weeks of the malignant diagnosis and produced transient neurological improvement. Due to symptomatic progression, ipilimumab plus nivolumab was commenced and achieved temporary radiographic stabilization, but the patient succumbed to diffuse progression later. Including this case, only five intracranial melanocytomas with malignant transformation treated with immune checkpoint inhibitors have been reported. Our experience supports initiating immunotherapy promptly after malignant transformation and suggests that sequential dual-agent blockade may modestly extend disease control.

Publicações recentes

Severe cord compression due to unique extradural meningeal melanocytoma of intermediate grade.

Surg Neurol Int2026

Meningeal Melanocytoma of the Lumbar Spinal Region: A Unique and Unusual Presentation.

Int J Surg Pathol2026 Jan 23

Aggressive Clinical Course and Malignant Transformation of a Meningeal Melanocytoma of the Pontomedullary Region: Diagnostic and Therapeutic Implications.

J Neurol Surg Rep2025 Oct

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma.

J Neurooncol2025 Dec 1

Primary Intracranial Meningeal Melanocytoma with Malignant Transformation: A Case Report and Comparison of Early Versus Late Immunotherapy Interventions.

Curr Oncol2025 Oct 24

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📚 EuropePMC144 artigos no totalmostrando 72

2026

Meningeal Melanocytoma of the Lumbar Spinal Region: A Unique and Unusual Presentation.

International journal of surgical pathology

Journal of neurological surgery reports

Aggressive Clinical Course and Malignant Transformation of a Meningeal Melanocytoma of the Pontomedullary Region: Diagnostic and Therapeutic Implications.

Journal of neuro-oncology

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma.

Current oncology (Toronto, Ont.)

Primary Intracranial Meningeal Melanocytoma with Malignant Transformation: A Case Report and Comparison of Early Versus Late Immunotherapy Interventions.

A T1-isointense meningeal melanocytoma mimicking meningioma: Case report and literature review.

Radiology case reports

Cerebellopontine Angle Meningeal Melanocytoma: A Rare Case and Literature Review of Outcomes and Recurrences.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Meningeal melanocytoma of the central nervous system in children.

Primary Meningeal Melanocytic Tumors of the Central Nervous System: A Review from the Ultra-Rare Brain Tumors Task Force of the European Network for Rare Cancers (EURACAN).

Cancers

Journal of surgical case reports

Intracranial meningeal melanocytoma: a case report and literature review.

The Role of Radiotherapy for Meningeal Melanocytomas - A 20 Year Update.

In vivo (Athens, Greece)

A rare case of multifocal craniospinal leptomeningeal melanocytoma: A case report and scoping review.

Brain & spine

Invasive cellular blue nevus in the cervical spine: A case report.

Pathology oncology research : POR

Supratentorial meningeal melanocytoma mimicking meningioma: case report and literature review.

Malignant Transformation and Leptomeningeal Melanomatosis in a Primary Meningeal Melanocytoma: A Case Report and Review of Literature.

NMC case report journal

Intermediate grade meningeal melanocytoma of the posterior fossa, GNAQ mutation-positive.

Acta neurologica Belgica

Primary cervical meningeal melanocytoma with a dumbbell shape: Case report and review of the literature.

Journal of surgical case reports

Intradural extramedullary meningeal melanocytoma: a case report and literature review.

How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies.

Cancers

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.

Meningeal Melanocytoma- A Clinicohistological Masquerader.

Intracranial Meningeal Melanocytomas: Clinicoradiologic Characteristics and Outcomes.

Clinical Reasoning: A 67-Year-Old Woman With Abdominal Pain, Constipation, and Urinary Retention.

Neurology

Malignant Transformation and Metastatic Spread of Dumbbell-Shaped Meningeal Melanocytoma of the Cervical Spine: A Case Report and Literature Review.

Frontiers in surgery

Ear, nose, & throat journal

Intermediate-grade primary melanocytic neoplasm of the cerebellopontine angle: A diagnostic challenge.

Primary Meningeal Melanocytoma Located in the Craniovertebral Junction: A Case Report and Literature Review.

NMC case report journal

Ophthalmic plastic and reconstructive surgery

GNA11 Mutation in an Intracranial Melanocytoma with Orbital Involvement and Nevus of Ota.

Case reports in radiology

Suprasellar Melanocytoma with Leptomeningeal Seeding: An Aggressive Clinical Course for a Histologically Benign Tumor.

Intermediate-Grade Meningeal Melanocytoma in a 19-Month- Old Child with Difficulties in Differential Diagnosis and Management.

Turkish neurosurgery

Surgical neurology international

S-100-negative, GNA11 mutation-positive intramedullary meningeal melanocytoma of the thoracic spine: A radiographic challenge and histologic anomaly.

Asian journal of neurosurgery

Spinal Nerve Root Extradural Melanocytoma Progressing to Malignant Melanoma: A Case Report with Review of Literature.

Asian journal of neurosurgery

Recurrent Meningeal Melanocytoma of Cervical Spine: A Rare Case.

A challenging case of sporadic melanocytoma of the jugular foramen.

Neuro-Chirurgie

Future oncology (London, England)

A National Cancer Database analysis of the patterns of care for meningeal melanocytoma.

British journal of neurosurgery

Non-dysraphic extramedullary intradural spinal lipoma with neurocutaneous melanocytosis.

Nivolumab as adjuvant treatment for a spinal melanocytoma: A case report.

British journal of neurosurgery

Recurrent spinal meningeal melanocytoma at lumbar spine level: a case report.

British journal of neurosurgery

Definitive radiotherapy for meningeal brainstem melanocytoma: a case report.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Parietal Convexity Meningeal Melanocytoma: Radiologic-Pathologic Correlation.

Spine surgery and related research

Meningeal Melanocytoma Occurring at Epidural Region of the Cervical Spine.

Journal of neuropathology and experimental neurology

Identification of a Novel BRCA1 Alteration in Recurrent Melanocytoma Resulting in Increased Proliferation.

C6-T1 Intradural Extramedullary Ventral Meningeal Melanocytoma Resected Via Anterior Corpectomy with Reconstruction.

Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report.

A Rapidly Growing Cervical Meningeal Melanocytoma with a Dumbbell-Shaped Extension.

8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review.

Surgical Management of Primary Cerebellopontine Angle Melanocytoma: Outcome, Recurrence and Additional Therapeutic Options.

Usefulness of Neuromelanin Sensitive MRI for En Plaque Meningeal Melanocytoma Involving the Cavernous Sinus: A Case Report.

NMC case report journal

Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases.

[Meningeal melanoma arising from a preexisting meningeal melanocytoma: A clinical, pathological and cytogenetic study about one case].

Annales de pathologie

Surgical neurology international

Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report.

The Pan African medical journal

[Meningeal melanocytoma: aggressive evolution of a benign tumor: about 2 cases].

Journal of medical case reports

Intracranial meningeal melanocytoma diagnosed using an interdisciplinary approach: a case report and review of the literature.

The Egyptian journal of neurology, psychiatry and neurosurgery

Spinal meningeal melanocytoma in a 5-year-old child: a case report and review of literature.

Primary Meningeal Melanocytoma in Sellar Region, Simulating a Nonfunctioning Pituitary Adenoma: Case Report and Literature Review.

Asian journal of neurosurgery

2017

Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature.

2017

[Melanocytoma and meningeal melanocytosis, similar but different lesions].

Cirugia y cirujanos

2017

Diagnostic Clue of Meningeal Melanocytoma: Case Report and Review of Literature.

Yonsei medical journal

Pathology, research and practice

Orbital meningeal melanocytoma: Histological, immunohistochemical and molecular characterization of a case and review of the literature.

The spine journal : official journal of the North American Spine Society

Primary scattered multifocal melanocytomas in spinal canal mimicking neurofibromatosis.

Journal of neuro-oncology

Spinal meningeal melanocytomas: clinical manifestations, radiological and pathological characteristics, and surgical outcomes.

Primary meningeal melanocytoma mimicking a nonfunctioning pituitary adenoma.

Clinical neuropathology

Case reports in radiology

Cervical Spinal Meningeal Melanocytoma Presenting as Intracranial Superficial Siderosis.

Squash cytopathology of primary meningeal melanocytoma.

Lung India : official organ of Indian Chest Society

Unusual lesions of the mediastinum.

International journal of clinical and experimental pathology

A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index.

The GNAQ in the haystack: intramedullary meningeal melanocytoma of intermediate grade at T9-10 in a 58-year-old woman.

Journal of neurosurgery

The American journal of forensic medicine and pathology

Sudden Death and Primary Leptomeningeal Melanocytosis: A Case Report With an Autopsy Diagnosis.

Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case.

Neurology

Meningeal melanocytoma of the middle cranial fossa (the Meckel's cave).

Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature.

Melanoma research

Primary Meningeal Melanocytoma in the Left Temporal Lobe Associated with Nevus Ota: a Case Report and Review of the Literature.