Raras
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Nevus de Ota
ORPHA:263425CID-10 · D22.3CID-11 · LC10DOENÇA RARA

A melanocitose dérmica congênita, também conhecida como mancha mongol, é uma marca de nascença de formato irregular, de cor azul-acinzentada. São áreas planas e geralmente afetam a parte inferior das costas; embora outras áreas possam estar envolvidas. Geralmente melhoram por volta dos seis anos de idade; embora alguns não se resolvam completamente.

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Introdução

O que você precisa saber de cara

📋

Mancha congênita azul-acinzentada na pele, geralmente unilateral, afetando face, olhos e, às vezes, mucosas. Pode aumentar o risco de glaucoma e melanoma uveal.

Publicações científicas
471 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D22.3
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Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico471PubMed
Últimos 10 anos200publicações
Pico202524 papers
Linha do tempo
2026Hoje · 2026🧪 2004Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

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Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
1Fase 11
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 3 ensaios
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Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Nevus de Ota

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

3 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
196 papers (10 anos)
#1

A Case of Nevus of Ota Associated with Agminated Blue Nevus.

Clinical, cosmetic and investigational dermatology2026

Dermal melanocytosis is characterized by the presence of spindle-shaped melanocytes in the dermis. Common forms include Mongolian spots, nevus of Ota, nevus of Ito, and blue nevus. Nevus of Ota typically presents as bluish-brown patches involving the sclera and the cutaneous regions innervated by the ophthalmic and maxillary branches of the trigeminal nerve unilaterally. Blue nevus usually manifests as a solitary lesion. Agminated blue nevus is a rare variant that often presents as grouped, linear, or blaschkoid-distributed deep blue macules or papules. Only a few cases have reported the co-occurrence of nevus of Ota and agminated blue nevus. We herein report a case of extensive nevus of Ota combined with agminated blue nevus involving all three branches of the trigeminal nerve.

#2

Clinical and dermoscopic characteristics of facial hyperpigmentation disorders in skin of color.

Actas dermo-sifiliograficas2026 Mar 20

Facial hyperpigmentation disorders (FHD) are common in dermatology, particularly in people with skin of color (SOC). They include melasma, post-inflammatory hyperpigmentation, and less frequent conditions such as exogenous ochronosis, lichen planus pigmentosus, Riehl's melanosis, acanthosis nigricans, seborrheic melanosis, pigmentary demarcation lines, drug-induced pigmentation, and nevus of Ota, among others. These conditions may significantly affect quality of life. They can present similar clinical and dermoscopic features, making diagnosis challenging. A thorough medical history, physical examination, and careful dermoscopic evaluation are essential to achieve an accurate diagnosis. In this article, we present a narrative review of the clinical and dermoscopic characteristics of FHD in SOC and provide diagnostic clues for the early diagnosis of these conditions.

#3

Uveal melanoma associated with Nevus of Ota in a German Shepherd dog.

Australian veterinary journal2026 Mar 12

A 4-year-old male German Shepherd dog was presented with a 3-day history of ocular pain in the right eye. The owner reported facial skin hyperpigmentation on the right side since puppyhood, consistent with a congenital condition known as Nevus of Ota or (oculo)dermal melanocytosis. Ophthalmological examination of the right eye revealed diffuse corneal oedema, vascular scleral congestion, diffuse iris hyperpigmentation, iris bombè and dyscoria; intraocular pressure was markedly elevated (41 mmHg). Ipsilateral facial skin was diffusely hyperpigmented along ophthalmic and maxillary branch innervation. The left eye showed no abnormalities. Ultrasonography of the right eye revealed severe iris thickening. Despite medical management consisting of topical anti-inflammatory and antiglaucoma therapy, clinical signs progressively worsened over the following 4 months, and enucleation was ultimately performed; the globe was subsequently submitted for histopathological examination. Preoperative thoracic radiography and abdominal ultrasonography were declined by the owner. Histopathologically, the anterior uveal architecture was completely affected by an infiltrating neoplasia, with transscleral extension to surrounding orbital tissues. An anterior uveal mixed cell type, scarcely melanotic melanoma was diagnosed. The dog died because of suspected pulmonary metastases 2 months after enucleation. To the best of our knowledge, this is the first report of a uveal melanoma associated with the nevus of Ota in a dog.

#4

Investigating the efficacy and safety of the 755-nm picosecond alexandrite laser in treating nevus of Ota: A systematic review and meta-analysis.

Medicine2026 Feb 20

The nevus of Ota is an uncommon pigmentary skin condition that causes bluish-gray pigmentation and is traditionally treated with a Q-switched laser. Emerging evidence suggests that the 755-nanometer picosecond alexandrite laser is a safe and effective therapeutic option. We sought to determine the overall effectiveness and safety profile of the 755-nanometer (nm) picosecond alexandrite laser for managing nevus of Ota. We reviewed 6 databases for studies that addressed the safety as well as efficacy profile of the 755-nm picosecond alexandrite laser for nevus of Ota. Ten studies, including 558 individuals with nevus of Ota, were included. The main outcomes were the rate of excellent clinical response and reported side effects encompassing erythema as well as post-inflammatory pigmentary alterations, including both hyperpigmentation and hypopigmentation. Review Manager Version 5.4 and Comprehensive Meta-Analysis v3 software were used for data analysis. The pooled excellent clinical response rate for the 755-nm picosecond alexandrite laser was found to be 36.8% (95% confidence interval [24.4-51.2%], P = .642). Post-inflammatory hyperpigmentation and hypopigmentation were each observed in 20.6% and 12.2% of the cases (P-value < .001), respectively. Post-inflammatory erythema, assessed in 2 studies (n = 23), demonstrated a pooled prevalence of 45.2% (95% confidence interval: 12.9-82.2%). The 755-nm picosecond alexandrite laser demonstrated moderate effectiveness and a favorable safety profile in the treatment of nevus of Ota. Pigmentary complications occurred at relatively low rates across the included studies. Further high-quality prospective and randomized controlled trials are required to confirm long-term effectiveness and safety.

#5

Bilateral nevus of Ota series treated with picosecond laser.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology2026 Feb 10

Nevus of Ota (NO) "oculodermal melanocytosis" is prevalent in Asians. Bilateral nevus of Ota (BNO) is a rare condition and comprises 5% of the cases seen. Picosecond laser (PS) is useful in treating various cutaneous benign pigmentary disorders including NO. We analyzed the clinical data on BNO in Vietnamese patients and evaluated the efficacy of treatment of the 1064 nm Nd:YAG picosecond laser (PSNY). Twenty-nine Vietnamese patients (ages 2-67 years, mean 23.36 ± 17.5) with BNO received at least 3 treatment sessions with 1064-nm PSNY (4-5 mm spot size; 1.5-2.4J/cm2, 4-week intervals). Improvement was documented through serial photographs that were taken at baseline (T0), after 4 weeks of the 3rd session (T1), 6th session (T2), 9th session (T3), and more than 10 sessions (T4). Response to the treatment was graded based on a 5-point grading scale. The participants were predominantly female (23 females, 6 males). Sclera, nasal mucosa, and pharyngeal NO lesions were observed in 24 patients (51.7%, 69%, and 6.9%, respectively). Two cases (6.89%) had lesions combined with Port-Wine-Stains. In the majority of cases, more than two branches of the trigeminal nerve were involved (89.66%). Onset of the lesions at <10 years old was 69% and involvement of more than two branches of the trigeminal nerve in these patients was 89.66%. Overall, 100% of patients demonstrated an improvement of the BNO lesions following treatment. A total of 88.9% of patients demonstrated a score compatible with good improvement to complete clearance after 9 treatment sessions on the treatment scoring scale. No severe adverse events or complications were observed. The 1064-nm PSNY laser has the potential to achieve faster clearance for treating dermal pigmentary disorders in Asians. To our knowledge, this is the largest reported series of BNO treated with a laser. Our results suggest that 1064-nm PSNY laser treatment is efficacious and an appropriate therapeutic modality for the treatment of BNO with minimal downtime and minimal adverse side effects.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC327 artigos no totalmostrando 193

2026

A Case of Nevus of Ota Associated with Agminated Blue Nevus.

Clinical, cosmetic and investigational dermatology
2026

Clinical and dermoscopic characteristics of facial hyperpigmentation disorders in skin of color.

Actas dermo-sifiliograficas
2026

Uveal melanoma associated with Nevus of Ota in a German Shepherd dog.

Australian veterinary journal
2026

Investigating the efficacy and safety of the 755-nm picosecond alexandrite laser in treating nevus of Ota: A systematic review and meta-analysis.

Medicine
2026

Bilateral nevus of Ota series treated with picosecond laser.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2025

Secondary Glaucoma Resulting From Choroidal Melanoma in a Patient With Congenital Nevus of Ota.

Case reports in ophthalmological medicine
2026

Successful treatment of Hori nevus with a 755 nm ps alexandrite laser with a diffractive lens array.

JAAD case reports
2026

Theoretical Analysis of Large-Spot Picosecond Laser Treatment for Pigmented Lesions in Asian Skin.

Lasers in surgery and medicine
2025

Clear Cell Papulosis Associated With Multiple Developmental Abnormalities of the Skin.

Cureus
2025

Delayed but long-term resolution of nevus of Ota after cessation of picosecond 755-nm alexandrite laser treatments.

JAAD case reports
2025

Pigment Pathways Collide: A Rare Case of Retinitis Pigmentosa and Nevus of Ota.

Cureus
2025

Nevus of Ota with excellent response to Q-switched Nd:YAG pigmented laser: a case report.

Dermatology reports
2025

The efficacy and adverse reactions of 755 nm picosecond alexandrite laser on the treatment of nevus of Ota at different endpoints: A split-lesion, single-blinded, randomized controlled comparison study.

Journal of the American Academy of Dermatology
2025

Effectiveness and safety of picosecond neodymium:yttrium-aluminum-garnet 1064 nm-laser treatment of nevus of Ota in children.

JAAD international
2025

Treatment of Benign Pigmented Lesions Using Lasers: A Scoping Review.

Journal of clinical medicine
2025

A Case of Facial-Type Acquired Dermal Melanocytosis on the Lips Successfully Treated With Laser Therapy.

The Journal of dermatology
2025

Association Between Acquired Bilateral Nevus of Ota-Like Macules Patients' Clinical Characteristics and Melasma Induction/Exacerbation After Q-Switched Laser: A Decadal Comparative Study of 2675 Chinese Women in Two Different Periods.

Lasers in surgery and medicine
2025

Prevalence of glaucoma and characteristics of ocular manifestations in patients with Naevus of Ota.

BMJ open ophthalmology
2025

A Retrospective Study of Picosecond Alexandrite Laser Treatment for Acquired Bilateral Nevus of Ota-Like Macules in Children.

Lasers in surgery and medicine
2025

Laser Surgery in Pediatric Skin of Color Patients: A Systematic Review.

Pediatric dermatology
2025

Primary orbital melanoma in a patient with nevus of Ota.

Archivos de la Sociedad Espanola de Oftalmologia
2025

Bilateral nevus of Ota in association with nevus flammeus: a case report.

Dermatology reports
2025

Congenital halo nevus associated with vitiligo aggravated by lasers targeting nevus of Ota: a case report.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2025

Analysis of efficacy of picosecond laser treatment for nevus of Ota.

Lasers in medical science
2025

A Case of Nevus of Ota in Trinidad and Tobago.

Cureus
2025

[Choroidal melanoma with nevus of Ota].

Journal francais d'ophtalmologie
2025

Efficacy and Safety of 730-nm Picosecond Laser for the Treatment of Acquired Bilateral Nevus of Ota-like Macules.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2025

Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice.

International journal of women's dermatology
2025

Iris changes and pupillometry in Nevus of Ota.

Clinical &amp; experimental optometry
2025

A Rare Case of Episcleral Melanoma with GNAQ Mutation Arising from Nevus of Ota.

Ophthalmology
2024

Wilson's Disease and Nevus of Ota in a Child: A Case Report.

Case reports in ophthalmology
2024

Overlapping large facial nevus spilus and nevus of Ota: A case report diagnosed with dermoscopy and reflectance confocal microscopy.

Photodiagnosis and photodynamic therapy
2024

Teaching NeuroImage: Meningeal Melanoma Associated With Blue Nevi and Nevi of Ota.

Neurology
2025

Orbital Pigmented Epithelioid Melanocytoma Tumor Associated With Nevus of Ota (Oculodermal Melanocytosis).

Ophthalmic plastic and reconstructive surgery
2024

Acquired Bilateral Nevus of Ota-Like Macules: A Case Report.

Cureus
2024

Comparison of the efficacy and safety of a 730-nm picosecond titanium sapphire laser and a 1064-nm picosecond neodymium yttrium aluminum garnet laser for the treatment of acquired bilateral nevus of Ota-like macules: A split-face, evaluator-blinded, randomized, and controlled pilot trial.

Journal of cosmetic dermatology
2024

Early Treatment of Nevus of Ota in Children is More Effective and Beneficial to Mental Health: Observation on the Efficacy of Q-Switched Ruby Laser in Treating 159 Cases of Nevus of Ota in Children.

Clinical, cosmetic and investigational dermatology
2024

Diffuse neurofibroma within nevus of Ota on the left face.

JAAD case reports
2024

Efficacy of 785-nm Picosecond Titanium Sapphire Laser for Treatment of Brown Nevus of Ota Lesions in FST II-V: A Retrospective Analysis.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2024

A clinico-epidemiological study of different dermoscopic patterns in hyperpigmented facial lesions in a tertiary care centre.

Journal of cutaneous and aesthetic surgery
2024

Picosecond alexandrite laser treatment of nevus of Ota in children.

Lasers in surgery and medicine
2024

Advancements in Laser Therapies for Dermal Hyperpigmentation in Skin of Color: A Comprehensive Literature Review and Experience of Sequential Laser Treatments in a Cohort of 122 Indian Patients.

Journal of clinical medicine
2024

Concurrent Occurrence of Trichilemmal Cyst and Nevus of Ota: Case Series.

Cureus
2024

Interventional and device treatment of the periocular area.

Clinics in dermatology
2024

Results and Follow-Up of a Sequential Q-Switched Laser Therapy for Nevus of Ota in Infants.

Clinical, cosmetic and investigational dermatology
2024

Evaluation and management of benign tumors of the eye and eyelid.

Clinics in dermatology
2023

Nevus of Ota: Combination Treatment with Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser and Fractional CO2 Laser.

Journal of cutaneous and aesthetic surgery
2024

Exploring the potential of intradermal platelet-rich plasma in treating acquired bilateral nevus of Ota-like macule (Hori's nevus): A pilot study.

Journal of cosmetic dermatology
2023

Unilateral Hyperpigmented Facial Lesion Since Birth.

Cureus
2024

Dendritic Corneal Stromal Pigmentation: A Spillover of Nevus of Ota?

Ophthalmology
2024

GNAQ-mutated primary subcutaneous blue melanoma arising in naevus of Ota presenting as a skin-coloured forehead mass.

Pathology
2024

Shades of blue: Nevus of Ota in a child.

Journal francais d'ophtalmologie
2023

Image classification and auxiliary diagnosis system for hyperpigmented skin diseases based on deep learning.

Heliyon
2023

High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot.

The Journal of dermatological treatment
2023

Nevus of Ota in 8-year-old male.

The Pan African medical journal
2023

Acquired, bilateral nevus of Ota-like macules in children: Clinical findings in 46 patients.

Journal of the American Academy of Dermatology
2023

Changes in melanocytic nevi treated with laser hair removal: A systematic review.

Lasers in surgery and medicine
2024

RETRACTED: Neurocutaneous Melanosis and Nevus of Ota: A Brief Report.

Clinical pediatrics
2023

A retrospective study of 1064-nm Q-switched Nd:YAG laser therapy for acquired bilateral nevus of Ota-like macules.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2023

Efficacy and safety of Q-switched lasers for the treatment of naevus of Ota in children: a retrospective analysis.

Lasers in medical science
2023

Blue Nevus Hidden within the Nevus of Ota.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
2023

Prospective comparison study of a 550 picosecond 755 nm laser vs a 50 ns 755 nm laser in the treatment of nevus of Ota.

Lasers in medical science
2022

Aiming to personalized laser therapy for nevus of Ota: melanin distribution dependent parameter optimization.

Lasers in medical science
2022

The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.

European journal of dermatology : EJD
2022

Nevus of Ota on the auricle successfully treated with Q-switched ruby laser.

Drug discoveries &amp; therapeutics
2023

Treatment of Nevus of Ota in Black patients with the 1064 nm QS or picosecond laser and nonablative fractional photothermolysis.

Lasers in surgery and medicine
2022

S2k guideline: Laser therapy of the skin.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2023

An update on ophthalmological perspectives in oculodermal melanocytosis (Nevus of Ota).

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
2022

Long-Term Follow-up for 1,064-nm Nanosecond and Picosecond Laser Treatment of Acquired Bilateral Nevus of Ota-Like Macules.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2022

Nevus of Ota with ipsilateral optic disc pigmentation and pigmentary glaucoma.

Indian journal of ophthalmology
2022

Melanocytic Nevus With Elastophilic Features.

The American Journal of dermatopathology
2022

Laser Surgery for Dermatologic Conditions in Pediatric Patients.

Dermatologic clinics
2022

A Comparative Study of Dermatoscopic Features of Melasma and Hori's Nevus in Asian Patients.

The Journal of clinical and aesthetic dermatology
2022

Bilateral Phakomatosis Cesiomarmorata With Ocular Melanocytosis and Secondary Glaucoma.

Cureus
2022

Evaluation of Dermoscopic Features in Facial Melanosis with Wood Lamp Examination.

Dermatology practical &amp; conceptual
2022

Effectiveness of an epidermal growth factor-containing cream on postinflammatory hyperpigmentation after 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) in Asians: A split-face, double-blinded, randomized controlled study.

Journal of cosmetic dermatology
2021

Phacomatosis pigmentovascularis with sturge-weber syndrome and congenital glaucoma: A rare case report.

European journal of ophthalmology
2022

Efficacy and safety of picosecond 755-nm alexandrite laser for treatment of nevus of Ota in Taiwanese children: A retrospective study.

Lasers in surgery and medicine
2022

Hematoporphyrin monomethyl ether-mediated photodynamic therapy for phakomatosis pigmentovascularis type Ⅱ: A case report.

Photodiagnosis and photodynamic therapy
2021

Skin diseases in Asian individuals that you do not want to miss: A selection of unique or relatively more common conditions in Asian populations.

Clinics in dermatology
2022

GNA11 Mutation in an Intracranial Melanocytoma with Orbital Involvement and Nevus of Ota.

Ophthalmic plastic and reconstructive surgery
2021

Plexiform neurofibroma with nevus of ota-rare presentation.

Journal of oral and maxillofacial pathology : JOMFP
2022

Early Treatment Initiation Improves Outcomes in Nevus of Ota: A 10-Year Retrospective Study.

American journal of clinical dermatology
2021

Treatment of nevus of Ota with 1064 nm picosecond Nd:YAG laser: A retrospective study.

Dermatologic therapy
2022

Primary orbital melanoma associated with nevus of Ota.

International journal of dermatology
2021

Utility of anterior segment optical coherence tomography in the surgical planning of superficial sclerectomy in oculodermal melanocytosis (nevus of Ota): A case report and review of literature.

American journal of ophthalmology case reports
2021

Imatinib Mesylate-Induced Acquired Dermal Melanocytosis and Acquired Bilateral Nevus of Ota-Like Macules.

Annals of dermatology
2021

Beneficial Effects of Treatment With Low-Fluence 755-nm Q-Switched Alexandrite Laser for Nevus of Ota.

Lasers in surgery and medicine
2021

Symmetric facial macules in an Asian woman.

Dermatology online journal
2022

Efficacy and safety of 755 nm Q-switched Alexandrite Laser for Hori's nevus: a retrospective analysis of 482 Chinese women.

Lasers in medical science
2021

Novel Application of the 730 and 785 nm Picosecond Titanium Sapphire Lasers for the Treatment of Nevus of Ota.

Lasers in surgery and medicine
2022

Efficacy evaluation and treatment parameter optimization for laser surgery of Ota's nevus based on an advanced non-equilibrium bio-tissue heat transfer model.

Lasers in medical science
2021

Novel Findings about Myopia in Patients with Oculodermal Melanocytosis (Nevus of Ota).

Current eye research
2021

[Congenital ocular melanocytosis].

Revue medicale de Liege
2021

Fatal GNAQ-mutated CNS melanoma in an adolescent with nevus of Ota.

Pediatric dermatology
2021

Nevus of Ota with midface tumors and a vanishing orbital mass.

Clinical imaging
2020

[Laser treatment of pigmentation disorders].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
2020

[Treatment of nevus of Ota and Ito and epidermal nevus syndrome].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
2020

Primary acquired melanosis (PAM) without atypia/WHO low-grade conjunctival melanocytic intraepithelial lesion over areas of oculodermal melanocytosis.

BMJ case reports
2020

Combination of 1064-nm Q-switched neodymium-doped yttrium-aluminum-garnet laser with Modified Jessner's peel for the treatment of Nevus of Ota: A case series of seven patients.

Dermatologic therapy
2021

Current Practices in Pediatric Dermatology Laser Therapy: An International Survey.

Lasers in surgery and medicine
2021

Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis.

Lasers in medical science
2021

Melanoma in the setting of nevus of Ota: a review for dermatologists.

International journal of dermatology
2020

Gingival Lesion in a 23-Year-Old Woman with Nevus of Ota in the Gingiva.

Skinmed
2021

Long-Term Follow-Up for Q-Switched Nd:YAG Treatment of Nevus of Ota: Are High Number of Treatments Really Required? A Case Report.

Photobiomodulation, photomedicine, and laser surgery
2020

A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2020

A Study of Quality of Life in Patients with Facial Melanoses.

Indian dermatology online journal
2021

Ocular manifestations of facial port-wine stain, nevus of Ota, and phakomatosis pigmentovascularis in Asian patients.

Journal of the American Academy of Dermatology
2020

Use of a Picosecond Alexandrite Laser for Treating Acquired Bilateral Nevus of Ota-Like Macules in Chinese Patients.

Lasers in surgery and medicine
2021

Naevus of Ota: clinical characteristics and proposal for a new ocular classification and grading system.

The British journal of ophthalmology
2020

Mongolian spots as a finding in forensic examinations of possible child abuse-implications for case work.

International journal of legal medicine
2020

Successful and quick treatment of nevus of Ota with 755nm picosecond laser in Chinese.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2020

Treatment of Laser-Responsive Dermal Pigmentary Conditions in Type III-IV Asian Skin With a 755-nm Picosecond Pulse Duration Laser: A Retrospective Review of Its Efficacy and Safety.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2020

Congenital Triangular Alopecia Associated with Phakomatosis Pigmentovascularis Type II along with Klippel Trenaunay Syndrome.

Indian dermatology online journal
2020

[Nevus of Ota: A case report].

Journal francais d'ophtalmologie
2020

Neurofibromatosis Type 1 with Becker's Nevus and Nevus of Ota.

Indian journal of dermatology
2020

Efficacy and safety of the picosecond 755-nm alexandrite laser for treatment of dermal pigmentation in Asians-a retrospective study.

Lasers in medical science
2019

The color of skin: gray diseases of the skin, nails, and mucosa.

Clinics in dermatology
2020

Dermoscopic Findings of Nevus of Ota.

Balkan medical journal
2020

Successful treatment of a patient with multicolored nevus of Ota using a combination of 1064 and 532 nm Q-switched Nd:YAG lasers.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2020

Case report: nevus of Ota and nevus of Ito associated with meningeal melanocytosis.

Neurocirugia
2020

Therapeutic options for management of Hori's nevus: A systematic review.

Dermatologic therapy
2019

An extensive nevus of Ota with oro-buccal involvement: a case review and proposal of a new classification system.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
2020

In vivo reflectance confocal microscopy for evaluating common facial hyperpigmentation.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2019

Clinical and genetic characteristics of nevus of Ota with choroidal melanoma in Chinese.

Ophthalmic genetics
2019

Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.

The Journal of dermatology
2019

GNAQ and PMS1 Mutations Associated with Uveal Melanoma, Ocular Surface Melanosis, and Nevus of Ota.

Ocular oncology and pathology
2018

Usefulness of picosecond pulse alexandrite laser treatment for nevus of Ota.

Laser therapy
2019

Nevus of Ota - an intraoral presentation: a case report.

Journal of medical case reports
2019

Phakomatosis Pigmentovascularis: A Clinical Profile of 11 Indian Patients.

Indian journal of dermatology
2019

Glaucoma in Phacomatosis Pigmentovascularis in a Young African Adolescent Boy: A Case Report.

Journal of glaucoma
2019

Incidental bilateral naevus of Ota and naevus spilus.

BMJ case reports
2019

Congenital Dermal Melanocytosis on the Foot: A Case Report and Review of the Literature.

Annals of dermatology
2019

Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases.

World neurosurgery
2020

Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial.

Journal of the American Academy of Dermatology
2019

Variables that predict response of nevus of ota to lasers.

Journal of cosmetic dermatology
2019

Oculodermal Melanocytosis: Nevus of Ota in a Dog.

Veterinary pathology
2018

Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report.

Surgical neurology international
2019

Nevus of Ota, a classic presentation.

Medicina clinica
2019

Using a car phone holder for performing oculoscopy with a universal serial bus dermatoscope.

Journal of the American Academy of Dermatology
2019

Late-onset naevus of Ota: a case series of six patients.

Clinical and experimental dermatology
2018

Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis.

Cutis
2018

Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules.

JAMA dermatology
2019

Laser therapy for ocular lesions of naevus of Ota.

The Australasian journal of dermatology
2019

Characteristics and management of Asian skin.

International journal of dermatology
2019

Optimizing Q-switched lasers for melasma and acquired dermal melanoses.

Indian journal of dermatology, venereology and leprology
2018

Port-wine stain as a clue for two rare coexisting entities.

BMJ case reports
2018

Classification of non-tumorous skin pigmentation disorders using voting based probabilistic linear discriminant analysis.

Computers in biology and medicine
2018

Orbital melanocytoma: When a tumor becomes a relieving surprise.

American journal of ophthalmology case reports
2019

Pathophysiology and management of glaucoma associated with phakomatoses.

Journal of neuroscience research
2018

Agminated Dermal Melanocytosis in the Territory of Ota's Nevus.

Actas dermo-sifiliograficas
2018

A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2018

[Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report].

No shinkei geka. Neurological surgery
2018

Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation.

Lasers in medical science
2017

Clinical profile of 300 men with facial hypermelanosis.

Journal of dermatological case reports
2018

Picosecond alexandrite laser for Naevus of Ota treatment in Chinese.

Journal of the European Academy of Dermatology and Venereology : JEADV
2018

Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases.

Journal of the European Academy of Dermatology and Venereology : JEADV
2018

A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules.

Journal of the American Academy of Dermatology
2018

Successful and safe use of Q-switched lasers in the treatment of nevus of Ota in children with phototypes IV-VI.

Lasers in surgery and medicine
2018

Agminated segmental plaque-type blue nevus associated with hypertrichosis and soft tissue hypertrophy: Report of a case and review of the literature.

Pediatric dermatology
2018

A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser.

Lasers in medical science
2017

Symmetrical hyperpigmentation of the forehead in a 37-year-old female patient from Guinea, West Africa.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2017

Laser treatment of medical skin disease in women.

International journal of women's dermatology
2017

Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience.

Annals of dermatology
2018

Nevus of Ota (oculodermal melanocytosis) in a dog.

Veterinary ophthalmology
2017

[Vitiligo occurring on dermal melanocytosis (nevus of Ota) in a dark-skinned patient].

Annales de dermatologie et de venereologie
2017

Successful treatment of Ota nevus with the 532-nm solid-state picosecond laser.

Cutis
2017

Malignant Orbital Melanoma Associated with Oculodermal Melanocytosis.

Ophthalmology
2017

Ocular Features in a Case of Nevus of Ota.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
2017

A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients.

Lasers in medical science
2017

Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules.

Cutaneous and ocular toxicology
2017

A case of blue naevus of the mucocutaneous junction of the lower eyelid margin associated with acquired bilateral naevus of Ota-like macule.

Clinical and experimental dermatology
2016

Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis).

Transactions of the American Ophthalmological Society
2016

Combination therapy in skin of color including injectables, laser, and light devices.

Seminars in cutaneous medicine and surgery
2016

Melanoma-Associated Spongiform Scleropathy in Oculodermal Melanocytosis with Primary Orbital Melanoma.

Ocular oncology and pathology
2016

Neurofibroma with naevus of Ota.

Clinical and experimental dermatology
2016

Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells.

Annals of dermatology
2016

Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review.

Laser therapy
2016

An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota.

Cureus
2017

[Heterochromia and unilateral iris nodules].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
2017

Phakomatosis pigmentovascularis type IIb: A case with Klippel-Trenáunay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots.

The Journal of dermatology
2016

A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser.

Indian journal of dermatology
2016

The use of picosecond lasers beyond tattoos.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2017

An Update on Oculodermal Melanocytosis and Rare Associated Conditions.

Seminars in ophthalmology
2017

A Novel Surgical Approach for Oculodermal Melanocytosis: Superficial Sclerectomy.

Eye &amp; contact lens
2016

Treatment of pigmentary disorders in patients with skin of color with a novel 755 nm picosecond, Q-switched ruby, and Q-switched Nd:YAG nanosecond lasers: A retrospective photographic review.

Lasers in surgery and medicine
2016

Three cases of symmetrical nevus of Ota and a brief literature review.

International journal of dermatology
2016

Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis.

Lasers in medical science
2016

Primary Melanoma of the Leptomeninges with BAP1 Expression-Loss in the Setting of a Nevus of Ota: A Clinical, Morphological and Genetic Study of 2 Cases.

Brain pathology (Zurich, Switzerland)
2016

Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2016

Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population.

The Journal of dermatology
2016

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

Pigment cell &amp; melanoma research
2016

A retrospective analysis on the management of pigmented lesions using a picosecond 755-nm alexandrite laser in Asians.

Lasers in surgery and medicine
Ver todos os 327 no EuropePMC

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Comunidades

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. A Case of Nevus of Ota Associated with Agminated Blue Nevus.
    Clinical, cosmetic and investigational dermatology· 2026· PMID 41869419mais citado
  2. Clinical and dermoscopic characteristics of facial hyperpigmentation disorders in skin of color.
    Actas dermo-sifiliograficas· 2026· PMID 41865981mais citado
  3. Uveal melanoma associated with Nevus of Ota in a German Shepherd dog.
    Australian veterinary journal· 2026· PMID 41814890mais citado
  4. Investigating the efficacy and safety of the 755-nm picosecond alexandrite laser in treating nevus of Ota: A systematic review and meta-analysis.
    Medicine· 2026· PMID 41731817mais citado
  5. Bilateral nevus of Ota series treated with picosecond laser.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology· 2026· PMID 41664593mais citado

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:263425(Orphanet)
  2. MONDO:0016984(MONDO)
  3. GARD:20901(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q2053690(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Nevus de Ota
Compêndio · Raras BR

Nevus de Ota

ORPHA:263425 · MONDO:0016984
Prevalência
Unknown
Herança
Not applicable
CID-10
D22.3 · Nevo melanocítico de outras partes e de partes não especificadas da face
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0027961
EuropePMC
Wikidata
Papers 10a
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