A perda auditiva retrococlear é um tipo de perda auditiva caracterizada pelo comprometimento das vias auditivas centrais ou do nervo vestibulococlear, estruturas localizadas após a cóclea. Distingue-se da perda auditiva periférica por afetar especificamente a transmissão neural do sinal sonoro em direção ao tronco encefálico e ao córtex auditivo, preservando geralmente a função coclear. A fisiopatologia decorre da interrupção na condução dos impulsos elétricos gerados na cóclea. Os fatores etiológicos podem envolver: compressão neural, desmielinização, degeneração axonal e dessincronização neural.
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Patologia otorrinolaringológica rara caracterizada por perda auditiva súbita de pelo menos 30 decibéis em três frequências contíguas, dentro de 72 horas ou menos, devido a lesão aguda das células ciliadas da cóclea, resultante de trauma acústico ou mecânico durante cirurgia ou ocorrendo sem qualquer causa. A perda auditiva pode afetar um ou ambos os ouvidos. Os sintomas concomitantes típicos são plenitude auricular, zumbidos e vertigens. Os doentes podem recuperar-se totalmente ou permanecer com perda auditiva de intensidade variável.
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🇧🇷 Atendimento SUS — Perda auditiva neurossensorial de início súbito
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Mostrando amostra de 200 publicações de um total de 1.831
Impact of contralateral sensorineural hearing loss on prognosis in idiopathic sudden sensorineural hearing loss.
The aim of this study was to investigate the impact of contralateral sensorineural hearing loss on prognosis in idiopathic sudden sensorineural hearing loss. A retrospective analysis was conducted on 445 ISSNHL patients treated between January 2020 and January 2024. The patients were divided into two groups: recovery (234 cases, including complete and partial recovery) and no-recovery (211 cases, no recovery). Pure-tone audiometry was used for evaluation. Clinical characteristics were compared between the groups, and multivariate logistic regression was performed to identify risk factors for poor prognosis. Significant differences were observed between the two groups regarding contralateral hearing level, age, duration of illness, diabetes, hypertension, and audiometric curves. An increase in the hearing threshold of the contralateral ear was positively correlated with the risk of ineffective treatment. Patients with contralateral sensorineural hearing loss prior to the onset of ISSNHL exhibited a 2.757-fold increased risk of treatment failure compared with ISSNHL patients who had normal contralateral ear hearing. Multivariate logistic regression analysis revealed that contralateral sensorineural hearing loss exhibited a significant multiplicative interaction with age over 60 years, hypertension, and a disease duration exceeding 4 days. The presence of contralateral sensorineural hearing loss before the onset of ISSNHL is an independent risk factor for poor prognosis in ISSNHL. It interacts significantly with age over 60 years, hypertension, and disease duration exceeding 4 days. A thorough assessment of contralateral hearing status, in conjunction with factors such as age, hypertension, and disease duration, is essential for developing personalized treatment plans to improve prognosis.
Microcirculatory Dysfunction and Oxidative Stress in Sudden Sensorineural Hearing Loss: Insights From a Case-Control and Experimental Study.
BACKGROUND Sudden sensorineural hearing loss (SSNHL) is an otological emergency with incompletely understood pathophysiology. Evidence suggests microcirculatory dysfunction and oxidative stress contribute to cochlear injury; however, their interrelationship remains insufficiently characterized. MATERIAL AND METHODS This prospective case-control study enrolled 100 patients with SSNHL and 100 age- and sex-matched healthy controls. Perfusion-related surrogate parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT), were assessed using dynamic contrast-enhanced magnetic resonance perfusion imaging. Peripheral microcirculation was evaluated by laser Doppler flowmetry. Systemic oxidative stress markers malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were quantified in serum. Experimental validation was performed using a rat ischemia-reperfusion model to assess cochlear oxidative stress, apoptosis, and auditory brainstem response thresholds. RESULTS Compared with controls, SSNHL patients exhibited reduced CBF and CBV, prolonged MTT, and lower peripheral microcirculatory perfusion (all P<0.05). Oxidative stress was increased in SSNHL, reflected by elevated serum MDA levels and reduced SOD and GSH-Px activities. Animal model showed ischemia-reperfusion induced parallel alterations, including increased cochlear oxidative stress, reduced antioxidant enzyme activity, increased apoptotic cell burden, and elevated auditory brainstem response thresholds. Perfusion-related parameters correlated with oxidative stress markers. Multivariable regression analysis demonstrated independent associations between perfusion profiles, oxidative imbalance, and hearing thresholds. CONCLUSIONS SSNHL is associated with unfavorable perfusion-related surrogate parameters and heightened oxidative stress accompanied by reduced antioxidant defenses. Clinical and experimental findings suggest microcirculatory dysfunction and oxidative imbalance are interrelated features of SSNHL-associated cochlear injury. Causal inference cannot be established, and further mechanistic studies are warranted.
Clinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study.
Although systemic corticosteroids remain the mainstay of therapy for idiopathic sudden sensorineural hearing loss (SSNHL), evidence of adherence to standardized treatment algorithms and their impact on hearing outcomes is limited. We conducted a retrospective analysis of a prospectively collected multicenter cohort comprising one university hospital, 16 affiliated hospitals, and two community clinics in Nagano Prefecture, Japan (2018-2024). Consecutive patients diagnosed with SSNHL were treated according to a unified algorithm derived from national epidemiological surveys. Adherence was defined as compliance with the initial and salvage therapies specified in the algorithm, and hearing outcomes were evaluated using the five-frequency pure-tone average (250-4,000 Hz) according to national criteria. Multivariable logistic regression with robust standard errors was used to identify determinants of adherence and factors associated with marked recovery (≥30 dB improvement). The overall adherence rate was 60.3% among 373 patients. Non-adherence was more prevalent in severe cases (Grade ≥3), among older patients (≥65 years), individuals with diabetes, and secondary referrals. Adherent cases showed better final hearing recovery than non-adherent ones (47.7% vs. 31.3%, p < 0.01). In cases of Grade ≥3, intravenous steroid therapy during initial treatment yielded greater early improvement than oral therapy (Grade 3: 46.0% vs. 25.0%, p = 0.018); however, there was no significant difference in final outcomes. Of the 110 patients requiring salvage treatment, intratympanic steroid injection was performed in 51.8% and was independently associated with superior recovery vs. observation (adjusted odds ratio, 14.35; 95% confidence interval, 1.60-128.42; p = 0.017). In this multicenter cohort, adherence to a standardized algorithm was moderate but was associated with improved hearing outcomes. In severe SSNHL, intravenous steroids enhance the early response-most notably in Grade 3-while salvage intratympanic steroid therapy considerably improves the final recovery rate. These findings support the implementation and optimization of the algorithm as well as the refinement of systemic dosing. Additionally, they highlight the importance of structured, guideline-based management in routine practice to improve outcomes in real-world SSNHL care.
Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.
The etiology of idiopathic sudden sensorineural hearing loss (iSSNHL) remains unclear, and genome-wide genetic evidence is limited. We conducted a multicenter Japanese case-control genome-wide association study including 192 clinically defined iSSNHL cases and 15,302 controls aged ≥80 years without a history of hearing loss. After cross-platform SNP harmonization and imputation (Eagle/Minimac4), association testing was performed using dosage-based logistic regression in PLINK 2.0, adjusting for sex and principal components (PC1-PC10). Gene- and pathway-level analyses were conducted using MAGMA and the PANTHER overrepresentation test. Genomic inflation was modest (λ_GC = 1.04). Eight loci reached genome-wide significance (p < 5 × 10-8), led by FHIT, with additional loci near LHX2, TRMT1L, MEGF10, SPATS1, SAMD5, MYT1L, and ID4; 21 loci met the suggestive threshold (p < 1 × 10-6). MAGMA identified eight genes at FDR < 0.05 (FHIT, TRMT1L, MEGF10, RNF2, SWT1, VAMP1, TAPBPL, and C9orf3). These findings suggest that immune-inflammatory and cellular stress-homeostasis mechanisms may contribute to iSSNHL susceptibility and provide candidate loci for future replication and functional studies.
Efficacy evaluation and clinical value exploration of secondary inpatient treatment for total deafness-type SSNHL: a single-center prospective study.
Total deafness-type sudden sensorineural hearing loss (SSNHL) represents one of the most challenging subtypes of SSNHL due to its poor response to initial therapy and uncertain prognosis. Secondary inpatient treatment has been proposed as a potential salvage strategy; however, its efficacy and predictors of favorable outcomes remain poorly defined. This study included 120 patients with unilateral total deafness-type SSNHL, divided into secondary treatment and control groups. Hearing thresholds at low, middle, high, and full frequencies, pure-tone average (PTA) at speech frequencies, and speech recognition rate were evaluated across six time points (T1-T6). Tinnitus Handicap Inventory (THI) scores and improvement rates were also analyzed. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of marked hearing recovery. A nomogram was constructed to predict the hearing prognosis of patients with SSNHL. Compared with the control group, the secondary treatment group exhibited significantly earlier onset and greater magnitude of improvements in hearing thresholds and speech recognition rate (all p < 0.05), with distinct frequency-specific patterns. Recovery initiated at 4-8 weeks and stabilized after 12 weeks, while the control group showed delayed improvement. Tinnitus relief occurred earlier in the secondary treatment group. Multivariate analysis identified age ≤50 years, disease duration ≤3 days, absence of vertigo, and normal vestibular function (vHIT and caloric test) as independent predictors of marked recovery (all p < 0.05). The area under the receiver operating characteristic (ROC) curve was 0.876 (95% confidence interval [CI]: 0.762-0.989). The calibration curve showed good agreement with the standard curve. The decision curve analysis demonstrated that the prediction model yielded positive net benefits across nearly all threshold probability ranges. Secondary inpatient treatment offers a significant auditory benefit for patients with total deafness-type SSNHL by accelerating and amplifying recovery. Young age, early intervention, and well-preserved vestibular function are key determinants of a favorable prognosis. The predictive model constructed hereby can effectively predict the prognosis of patients.
Publicações recentes
Evaluation of Brain Age on Magnetic Resonance Imaging Using Machine Learning Techniques in Patients With Hearing Loss.
Prospective Short-Term Observation for Spontaneous Recovery of Sudden Sensorineural Hearing Loss.
Evaluation of Extended Indications for Cochlear Implantation Beyond Conventional Criteria.
Hyperbaric Oxygen Therapy in Stroke-Related Sudden Hearing Loss: A Case Report.
Hydrogen: a novel strategy for preventing and treating hearing loss.
📚 EuropePMC1.978 artigos no totalmostrando 197
Treatment success in relation to timing of hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss.
Diving and hyperbaric medicineApolipoprotein AI is a protective factor for idiopathic sudden sensorineural hearing loss: a two-sample mendelian randomisation study.
International journal of audiologyCorrelation between single-nucleotide polymorphisms at the rs3745453 locus of the miR-23a gene and sudden sensorineural hearing loss in the Han population.
Neurological researchImpact of contralateral sensorineural hearing loss on prognosis in idiopathic sudden sensorineural hearing loss.
PloS oneMicrocirculatory Dysfunction and Oxidative Stress in Sudden Sensorineural Hearing Loss: Insights From a Case-Control and Experimental Study.
Medical science monitor : international medical journal of experimental and clinical researchEfficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryAssociation between modifiable lifestyle factors and the incidences of sudden sensorineural hearing loss and Meniere's disease: A population-based nested case-control study.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryTinnitus outcomes after ginkgo biloba extract in sudden sensorineural hearing loss: a dose-comparative and prognostic study.
Acta oto-laryngologicaRole of hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss management: A multicentre experience.
Medical journal, Armed Forces IndiaMigraine Features in Patients With Sudden Sensorineural Hearing Loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryAnti-myeloperoxidase-ANCA-associated vasculitis presenting with sudden sensorineural hearing loss: a case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyClinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study.
Frontiers in neurologyEpidemiologic Characteristics and Prognostic Analysis of 2030 Patients with Sudden Sensorineural Hearing Loss: A Single-Center Retrospective Study.
Ear, nose, & throat journalRegarding "Blood biomarkers of response to concomitant intratympanic and systemic corticosteroids treatment for idiopathic sudden sensorineural hearing loss".
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryAnalysis of genetic polymorphisms in sudden sensorineural hearing loss and artificial intelligence-supported individualized precision therapy.
Frontiers in neurologyPredictors of Hearing Recovery in Sudden Sensorineural Hearing Loss: Focus on Lipids, Glucocorticoids, and Predictive Model Performance.
Ear, nose, & throat journalHearing Recovery in Patients Treated for Idiopathic Sudden Sensorineural Hearing Loss.
American journal of audiologyGlymphatic system-dependent mechanisms connecting sudden sensorineural hearing loss to cognitive and emotional impairments.
Brain imaging and behaviorRole of platelet-rich plasma in management of sensorineural hearing loss diseases.
Vestnik otorinolaringologiiInflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.
International journal of molecular sciencesHyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss: Factors Affecting Benefits of Earlier Start and Longer Treatment Duration.
Diagnostics (Basel, Switzerland)Restoring Sound Localization in Single-Sided Deafness Through Cochlear Implantation: A Meta-Analysis.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyDifferentially expressed exosome miRNA profiles as putative prognostic biomarkers for profound sudden sensorineural hearing loss.
BMC medical genomicsSerum sCD163 indicates disease severity and prognosis in sudden sensorineural hearing loss.
Molecular medicine (Cambridge, Mass.)Notoginsenoside R1 as a Protector Against Gentamicin Ototoxicity: Targeting p62-NRF2-GPX4 Ferroptosis Axis.
Advanced biologyEfficacy evaluation and clinical value exploration of secondary inpatient treatment for total deafness-type SSNHL: a single-center prospective study.
Frontiers in neurologySudden Unilateral Hearing Loss and Vertigo in an Adolescent: Viral Labyrinthitis Versus Idiopathic Sudden Sensorineural Hearing Loss.
CureusAcupuncture combined with intratympanic dexamethasone for sudden sensorineural hearing loss: A randomised controlled trial.
QJM : monthly journal of the Association of Physicians[Pathophysiologically complex bilateral profound sensorineural hearing loss in the setting of type 2 diabetes mellitus and fungal sepsis: a case report].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery[Study on the characteristics of magnetic resonance hydrography of the inner ear in patients with total deafness-type sudden sensorineural hearing loss].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryThe Effect of Vestibular Migraine on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss.
American journal of audiologySudden Sensorineural Hearing Loss as the Presenting Symptom of Varicella Zoster Virus Rhombencephalitis: A Case Report.
CureusGenetically predicted cerebrospinal fluid metabolite levels and risk of sudden sensorineural hearing loss: A Mendelian randomization study.
MedicineX-Ray Repair Cross-Complementing Group 1 Genetic Polymorphisms and the Risk of Sudden Sensorineural Hearing Loss.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyMulti-model Artificial Intelligence Evaluation in Sudden Sensorineural Hearing Loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryPrognostic value of the video head impulse test in sudden sensorineural hearing loss with vertigo: a systematic review and meta-analysis.
Frontiers in neurologyDevelopment of a machine learning model for prognostic prediction of severe sudden sensorineural hearing loss with hyperbaric oxygen therapy.
Frontiers in neurologyThe impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.
American journal of otolaryngologyRelationship between different blood routine parameters and different types of sudden deafness and prognosis.
Frontiers in medicineDifferences in Intracochlear Electrocochleography Signal Characteristics of Meniere's Disease, Noise-Induced Hearing Loss, and Sudden Sensorineural Hearing Loss.
Ear and hearingVideo Head Impulse Test: A Prognostic Marker for Patients with Idiopathic Sudden Sensorineural Hearing Loss.
Audiology researchBrachial-Ankle Pulse Wave Velocity as Indicator on the Etiology of Idiopathic Sudden Sensorineural Hearing Loss.
Ear, nose, & throat journalCase report and literature review of subclavian steal syndrome presenting with otologic symptoms as the initial clinical manifestation.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryEvaluating TSH as a prognostic factor for hearing outcomes in sudden sensorineural hearing loss.
Acta oto-laryngologicaA case of Langerhans cell histiocytosis localized in the temporal bone, which presented as sudden sensorineural hearing loss: A case report and review of the literature.
SAGE open medical case reportsVitamin D Deficiency as a Risk Factor for Onset and Recurrence of Sudden Sensorineural Hearing Loss: A Prospective Cohort Study With Age-Specific Analysis.
Food science & nutritionComparable Outcomes in Pediatric and Adult Patients With Sudden Sensorineural Hearing Loss.
The LaryngoscopeManagement of Sudden Onset Sensorineural Hearing Loss and the Role of Pentoxyphylline as an Add-on Therapy to Conventional Treatment.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologySimultaneous Therapy Approach: Systemic and Intratympanic Corticosteroid for Idiopathic Sudden Sensorineural Hearing Loss: A Clinical Study.
Iranian journal of otorhinolaryngologyAssociation Between Tinnitus and Hearing Recovery in Sudden Sensorineural Hearing Loss: A Meta-analysis.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyEfficacy of intratympanic methylprednisolone versus standard therapy in adult sudden sensorineural hearing loss.
Frontiers in neurologyImpact of Autoimmune Diseases on the Prognosis of Unilateral Sudden Sensorineural Hearing Loss.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryEnvironmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review).
International journal of molecular medicineCogan's Syndrome: Complex Diagnostics, Treatment, and Results of Hearing Rehabilitation in Long-Term Follow-Up-Case Series.
Case reports in immunologyThe Role of Patient Motivation in Single-Sided Deafness: Patterns in Treatment Selection and Cochlear Implant Outcomes.
Journal of clinical medicineExpression and Roles of Free Radicals and Reactive Oxygen Species in Hearing Loss.
Antioxidants (Basel, Switzerland)[Association between blood lipid levels and prognosis in patients with sudden sensorineural hearing loss and development of a predictive model].
Zhonghua yi xue za zhiSeasonal and temporal patterns of sudden sensorineural hearing loss and audiogram types: insights from a decade-long STL-based retrospective analysis.
The Journal of laryngology and otologyAdjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss?
The LaryngoscopeBlood biomarkers of response to concomitant intratympanic and systemic corticosteroids treatment for idiopathic sudden sensorineural hearing loss.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgerySafety Of Hyperbaric Oxygen Therapy In Patients Aged 75 And Older: A Multicenter Retrospective Study.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, IncCarotid Artery Tortuosity With a Vertebral Artery Entering the Transverse Foramen at an Atypical Level: A Cadaveric Case Underlining the Need for Thorough Anatomical Assessment Before a Stellate Ganglion Block.
CureusExplainable machine learning model for predicting hearing recovery in unilateral sudden sensorineural hearing loss.
Brazilian journal of otorhinolaryngologyDexamethasone Dosing of Human Perilymph Compared for Common Delivery Protocols Using Inner Ear Simulations.
Audiology & neuro-otologyDexamethasone palmitate: A promising intratympanic treatment option for severe sudden hearing loss.
American journal of otolaryngologyQuality evaluation of information about sudden sensorineural hearing loss on TikTok videos: Cross-sectional study.
Digital healthDifferential expression of miR-23a-3p/-210-3p and /-18b-5p in sudden sensorineural hearing loss patients: A North American cohort study.
Scientific reportsCharacteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyImpact of vestibular dysfunction on short - term auditory outcome in severe to profound unilateral idiopathic sudden sensorineural hearing loss: a retrospective analysis.
Acta oto-laryngologicaAssociation Between Weather and Sudden Sensorineural Hearing Loss: A Nationwide Study in South Korea.
The LaryngoscopeHyperbaric oxygen therapy as salvage treatment for post-traumatic sudden sensorineural hearing loss: a case report.
Diving and hyperbaric medicineHyperbaric oxygen therapy for acute idiopathic sudden sensorineural hearing loss; a systematic review with meta-analysis.
Diving and hyperbaric medicineLow-Level Laser Therapy and Photobiomodulation for Tinnitus and Sudden Sensorineural Hearing Loss: A Systematic Review.
CureusSeasonality of Sensorineural Hearing Loss and Impact of the Coronavirus Disease 2019 Pandemic.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryNeurovascular compression and vestibular compromises in idiopathic sudden sensorineural hearing loss.
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-faccialeHarnessing Machine Learning for Personalized Care of Idiopathic Sudden Sensorineural Hearing Loss: A Multicenter Cohort Study.
Clinical and experimental otorhinolaryngologyPhoton-counting CT demonstration of acute labyrinthine ischemia in idiopathic sudden sensorineural hearing loss: a case report.
Frontiers in medicineHOW PRIMARY HEALTH CARE PHYSICIANS IN SAUDI ARABIA HANDLE SUDDEN SENSORINEURAL HEARING LOSS: A CROSS-SECTIONAL STUDY.
Georgian medical newsSeveral proteins derived from serum exosomes are potential biomarkers for diagnosis and progression of sudden sensorineural hearing loss.
Frontiers in neurologyDynamic Changes in Free Triiodothyronine (FT3) and Their Correlation with Hearing Recovery in Sudden Sensorineural Hearing Loss: Clinical Implications.
Journal of otologyIn Reference to NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial.
The LaryngoscopeEfficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial.
BMC medicineLymphocyte-to-monocyte ratio as a clinical predictor in sudden sensorineural hearing loss.
Brazilian journal of otorhinolaryngologyA case of an attic lesion presenting with unilateral hearing loss, diagnosed as a meningioma: a case report and review of the literature.
Journal of medical case reportsEvaluation of Prognostic Scores in Adult Patients with Idiopathic Sudden Hearing Loss.
Journal of clinical practice and researchEarly Outcomes of Cochlear Implantation for Pediatric COVID-19 Related Single Sided Deafness: Case Series and Literature Review.
The Annals of otology, rhinology, and laryngologyMetabolomic profiling reveals potential biomarkers for sudden sensorineural hearing loss.
Science progressAnalysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.
Diagnostics (Basel, Switzerland)The influence of mitochondrial biological function on sudden sensorineural hearing loss: Exploring potential mechanisms and associations through Mendelian randomization analysis.
MedicineLow Geriatric Nutritional Risk Index Predicts Unfavorable Outcomes in Older Sudden Sensorineural Hearing Loss Patients.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeComparing the efficacy of various acupuncture-related therapies for sudden sensorineural hearing loss: a PRISMA-compliant protocol for systematic review and network meta-analysis.
BMJ openPrognostic Value of the Triglyceride-Glucose Index in Idiopathic Sudden Sensorineural Hearing Loss.
Ear, nose, & throat journal[A randomized controlled trial of electronic balance assistant combined with pharmacotherapy for vestibular rehabilitation in patients with acute peripheral vestibular injury].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryApplication Analysis of T1WI and T2WI Combined with Delayed Enhanced Magnetic Resonance Technology in Sudden Sensorineural Hearing Loss.
Ear, nose, & throat journalImproving Clinical Management in ENT Casualty: A Multi-domain Quality Improvement Project Using a Digital Toolkit.
CureusClinical Characteristics and Correlation of Hearing Outcomes Following Varying Courses of Repetitive Transcranial Magnetic Stimulation for Idiopathic Sudden Sensorineural Hearing Loss: A Prospective Clinical Study.
Journal of clinical medicine[Prognostic factors and prediction model development for bilateral sudden sensorineural hearing loss].
Zhonghua yi xue za zhiInterventions for sudden sensorineural hearing loss: a systematic review and quality assessment of clinical practice guidelines.
International journal of audiologyComparison of the efficacy and safety of intratympanic application of different corticosteroids: a systematic review and meta-analysis.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryRetrospective Review of MR Findings in Sudden Sensorineural Hearing Loss and Associated Clinical Features.
AJNR. American journal of neuroradiologyCan Chatbots Please Both Patients and Experts? Benchmarking AI and Clinical Guidelines for Hearing Loss.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyBilateral Sudden on Chronic Hearing Loss as an Auditory Manifestation of Mitochondrial DNA Mutations.
The LaryngoscopeIntratympanic dexamethasone microcrystals/lidocaine-loaded PLGA non-spherical microparticles for local drug delivery to the inner ear.
Animal models and experimental medicineThe Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.
International immunopharmacologyAcute Bilateral Hearing Loss: An Unheard of Thalamic Syndrome.
The neurologist[Relationship between short-term prognosis and symptoms of vertigo and vestibular function in patients with unilateral flat descending sudden sensorineural hearing loss].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryOptical coherence tomography angiography findings in patients with sudden sensorineural hearing loss.
Scientific reportsIntratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss.
PloS oneClinical efficacy of vitamin D combined with conventional therapy for sudden sensorineural hearing loss in patients with vitamin D deficiency: a randomized controlled trial.
Head & face medicinePrecision and prediction matter: investigating hearing recovery measurements and prognosis in sudden sensorineural hearing loss.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryCorrelation of skull vibration-induced nystagmus test and video head impulse test in patients with sudden sensorineural hearing loss with vertigo.
Frontiers in neurologyNAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial.
The LaryngoscopeEffects of pregnancy and pregnancy-related conditions on the inner ear: a systematic review.
The Journal of laryngology and otologyDehydration-associated cerebral hypoperfusion in sudden sensorineural hearing loss: an arterial spin labeling-based preliminary study.
Frontiers in neurologyA novel audiogram model for predicting the prognosis of sudden sensorineural hearing loss.
Journal of the Chinese Medical Association : JCMACausal associations of renal function and sudden sensorineural hearing loss: Evidence from a two-sample multivariable Mendelian randomization study with case-control validation.
MedicineWhite Matter Changes in Cases with Unilateral Idiopathic Sudden Sensorineural Hearing Loss Indicated by Diffusion Tensor Imaging Based on Tract-Based Spatial Statistics.
The journal of international advanced otologyInfluence of the type of onset of hearing loss in the hearing impairment after long time progression in menière's disease.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryA Higher Liver Fibrosis-4 Index Is Associated With More Severe Hearing Loss in Idiopathic Sudden Sensorineural Hearing Loss.
CureusDouble Trouble: Unveiling the Rare Co-occurrence of Neurofibromatosis Type 1 and Multiple Sclerosis.
CureusIdiopathic sudden sensineural hearing loss: demographic data and treatment in ENT practices in Germany (2014-2023).
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgerySCORE 2 and SCORE 2-OP Risk Scales as Prognostic Factors After Sudden Idiopathic Hearing Loss.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryPredictive immunonutritional biomarkers for the severity and recovery of sudden sensorineural hearing loss: a prospective clinical study.
Frontiers in neurologyHyperbaric oxygen therapy for sudden sensorineural hearing loss (Review).
Molecular medicine reportsMeteorological Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Study.
CureusSerum transferrin as a potential marker for prediction of prognosis for sudden sensorineural hearing loss: a prospective study.
BMC neurologyAudiogram Shape: Does It Have a Significant Prognostic Role in Idiopathic Sudden Sensorineural Hearing Loss Outcome?
Journal of personalized medicineMachine-Learning Models With Multiple Imputation With Sequential Nearest Neighbors Imputation for Predicting the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss Patients.
Ear and hearing[Prognostic factors and construction of a predictive model for patients with refractory low-frequency sudden sensorineural hearing loss].
Zhonghua yi xue za zhiTreatment of idiopathic sudden sensorineural hearing loss with press needle.
JPMA. The Journal of the Pakistan Medical Association[Preliminary analysis of the factors affecting sound localization in patients with unilateral sudden sensorineural hearing loss].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery[The changes and analysis of the ability of sound localization for patients with unilateral sudden hearing loss during the early period of treatment].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryAnalysis of the clinical value of triiodothyronine levels in sudden sensorineural hearing loss: A retrospective observational study.
MedicineClinical characteristics and caloric testing in patients with light or heavy cupula of the horizontal semicircular canal.
Frontiers in neurologyEfficacy of hyperbaric oxygen salvage therapy for sudden sensorineural hearing loss after ineffective primary treatment in the Slovak Republic.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, IncAssessment of Safety, Tolerability, Pharmacokinetics, and Volume-Dependent Conductive Hearing Loss in Healthy Volunteers: First-in-Human, Open-Label, Placebo-Controlled Study of a Single Intratympanic Injection of AC102.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyImmune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis.
Journal of affective disordersCorrelation of air pollution and risk of sudden sensorineural hearing loss: a Mendelian randomization study.
Scientific reportsAltered cerebellar functional connectivity and topography in patients with unilateral sudden sensorineural hearing loss.
Hearing researchBilateral Enlarged Vestibular Aqueduct: Auditory, Genetic and Radiological Characterization, and Benefits of Cochlear Implants.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryComparative Analysis of Therapeutic Methods for Sudden Sensorineural Hearing Loss.
Clinical pharmacology in drug developmentHyperbaric Oxygen and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.
The LaryngoscopeImpact of Hyperbaric Oxygen Therapy on Recovery in Patients With Sudden Sensorineural Hearing Loss: An Observational Study.
Journal of audiology & otologyAuricular Point Sticking for Patients with Sudden Sensorineural Hearing Loss: A Propensity Score Matching Analysis.
International journal of general medicineSalvage treatment strategies for refractory sudden sensorineural hearing loss-a comprehensive review and meta-analysis with practical recommendations.
Frontiers in neurologyUntargeted plasma metabolite detection in sudden sensorineural hearing loss: identifying key metabolic signatures.
Frontiers in molecular biosciencesThe Challenge of Diagnosing Labyrinthine Stroke-A Critical Review.
Brain sciencesPosterior circulation infarction with sudden deafness as a clinical manifestation.
The American journal of emergency medicine"An Unusual Case of Bilateral Sudden Mixed Hearing Loss with Complete Remission": A Case Report and Pathophysiological Considerations.
Reports (MDPI)Sleep Assessment in Patients with Inner Ear Functional Disorders: A Prospective Cohort Study Investigating Sleep Quality Through Polygraphy Recordings.
Audiology researchAssociation Between Hematological Indices of Inflammation and Pathogenesis and Prognosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.
The journal of international advanced otologySudden Sensorineural Hearing Loss in an Immunocompetent Patient With West Nile Encephalitis.
Laryngoscope investigative otolaryngologyCourse of a sudden sensorineural hearing loss case diagnosed as intra-labyrinthine hemorrhage with MRI in the early phase.
Auris, nasus, larynxNeurotologic Findings of Idiopathic Acute Unilateral Audiovestibulopathy.
European journal of neurologyPrognostic analysis and nomogram prediction model construction of severe full-frequency sudden sensorineural hearing loss.
The Journal of laryngology and otologyEfficacy of methylprednisolone sodium succinate combined with acoustic resonance therapy on inflammatory response indicators and cerebral microcirculation in patients with sudden sensorineural hearing loss.
European journal of medical researchOnset of sudden sensorineural hearing loss: An update.
Australian journal of general practiceAssociation Between High Jugular Bulb and Sudden Sensorineural Hearing Loss: A Computed Tomography Based Study.
International journal of general medicineOptimising Early Intervention: A Retrospective Study on the Role of Hyperbaric Oxygen Therapy in Enhancing Hearing Recovery for Sudden Sensorineural Hearing Loss.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryTargeting NLRP3/caspase-1/GSDMD to treat inner ear injury from labyrinthine hemorrhage.
Molecular therapy : the journal of the American Society of Gene TherapyAssessing the Role of Nystagmus Slow Phase Velocity as a Prognostic Indicator in Idiopathic Sudden Sensorineural Hearing Loss: A Prospective Study.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyCharacteristics of adverse drug reactions and risk management strategies for methylprednisolone sodium succinate in the treatment of idiopathic sudden sensorineural hearing loss: a clinical study of 1026 patients.
Frontiers in medicineAnalysis of factors influencing the effective dose of intratympanic steroid injection of dexamethasone in idiopathic sudden sensorineural hearing loss.
Acta oto-laryngologicaAcute Respiratory Tract Infection and Sudden Sensorineural Hearing Loss: A Multinational Cohort Study.
Diagnostics (Basel, Switzerland)Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss.
Bioengineering (Basel, Switzerland)Vestibular dysfunction and hearing outcome in idiopathic sudden sensorineural hearing loss.
The Journal of laryngology and otologyElectroacupuncture for Sudden Sensorineural Hearing Loss: A Case Report.
Medical acupunctureApplication of metabolomics to acquired hearing loss: Advances and systematic review.
Hearing researchUtility of Prognostic Nutritional Index and Systemic Immune-Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study.
Immunity, inflammation and diseasePredicting the prognosis of patients with sudden sensorineural hearing loss by analyzing the audiometric curve of the unaffected ear.
Frontiers in neurologyThe effect of aging on hearing outcomes after sudden sensorineural hearing loss (SSNHL): A retrospective study.
Archives of gerontology and geriatricsValidation and Development Testing of the Symptom Group Assessment Scale for Patients With Sudden Deafness: A Comprehensive Study.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryTherapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients.
World journal of diabetesCo-occurrence of Otologic Disorders and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis.
Clinical and experimental otorhinolaryngologyA Scoring System for Predicting the Cure Rate of Unilateral Idiopathic Sudden Sensorineural Hearing Loss.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryA pilot study for virus-induced neural network remodeling in sudden hearing loss and tinnitus: A graph attention network approach.
Computers in biology and medicineExploring Research Challenges in the Study of Sudden Sensorineural Hearing Loss: An Investigation Utilizing a Large Single Clinical Practice Database.
The Annals of otology, rhinology, and laryngologyAlterations in functional connectivity related to prognosis in unilateral sudden sensorineural hearing loss.
Hearing researchGlobal trends and hotspots in research for sudden hearing loss over the past two decades: a bibliometric and visualization analyses.
Frontiers in neurologyAdverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryIntratympanic Injection of Edaravone for Idiopathic Sudden Sensorineural Hearing Loss with Profound Hearing Loss.
The journal of international advanced otologyEvaluating hyperbaric oxygen therapy as an adjunct to corticosteroids in sudden sensorineural hearing loss: a systematic review and meta-analysis.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryRetrospective analysis of different application methods in intratympanic glucocorticoid therapy for treatment of idiopathic SSNHL: A comparative outcome study.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryExploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples.
PloS oneThe prognostic value of systemic immune-inflammation index and lymphocyte-to-monocyte ratio in cases with profound sudden sensorineural hearing loss.
American journal of otolaryngologyCombination of Electroacupuncture and Medication for Patients With Tinnitus Associated With Idiopathic Sudden Sensorineural Hearing Loss: Protocol for a Prospective Randomized Controlled Trial.
JMIR research protocolsDrug-induced hypesthesia due to dexamethasone: A case report.
MedicineAssociation of Metabolic Dysfunction-Associated Steatotic Liver Disease With Sudden Sensorineural Hearing Loss Among Older Adults.
Laryngoscope investigative otolaryngologyMRI evidence of inner ear hemorrhage in prognostic assessment of sudden sensorineural hearing loss.
American journal of otolaryngologyRisk factors and Occurrence of Small vessel disease in Acute sensorineural hearing Loss In the Elderly: protocol for a multicentre cross-sectional study.
BMJ openIntratympanic steroid via saturated gelfoam vs. intratympanic injection for sudden sensorineural hearing loss.
Auris, nasus, larynxEffect of elderly patients with diabetes mellitus on the prognosis of idiopathic sudden sensorineural hearing loss.
Auris, nasus, larynxPentoxifylline uses in inner ear diseases.
European journal of clinical pharmacologyA pilot study on the effect of SARS-CoV-2 spike protein on IL-1β-mediated inflammation in peripheral blood immune cells from AIED patients.
Molecular medicine (Cambridge, Mass.)Examination of Pan-Immune-Inflammation Value and Lymphocyte-Monocyte Ratio in Sudden Sensorineural Hearing Loss.
Nigerian journal of clinical practiceThe effect of blood glucose and lipid risk factors on idiopathic sudden sensorineural hearing loss: A two-sample Mendelian randomization study.
Brazilian journal of otorhinolaryngologyIntratympanic steroid injection for treating sudden sensorineural hearing loss in patients with hepatitis B virus infection.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Impact of contralateral sensorineural hearing loss on prognosis in idiopathic sudden sensorineural hearing loss.
- Microcirculatory Dysfunction and Oxidative Stress in Sudden Sensorineural Hearing Loss: Insights From a Case-Control and Experimental Study.Medical science monitor : international medical journal of experimental and clinical research· 2026· PMID 41851951mais citado
- Clinical impact of adherence to a standardized treatment algorithm for idiopathic sudden sensorineural hearing loss: a multicenter cohort study.
- Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.
- Efficacy evaluation and clinical value exploration of secondary inpatient treatment for total deafness-type SSNHL: a single-center prospective study.
- Evaluation of Brain Age on Magnetic Resonance Imaging Using Machine Learning Techniques in Patients With Hearing Loss.
- Prospective Short-Term Observation for Spontaneous Recovery of Sudden Sensorineural Hearing Loss.
- Evaluation of Extended Indications for Cochlear Implantation Beyond Conventional Criteria.
- Hyperbaric Oxygen Therapy in Stroke-Related Sudden Hearing Loss: A Case Report.
- Hydrogen: a novel strategy for preventing and treating hearing loss.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:90059(Orphanet)
- MONDO:0043373(MONDO)
- GARD:12927(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
