Raras
Buscar doenças, sintomas, genes...
Puberdade precoce central secundária no indivíduo feminino
ORPHA:650082CID-10 · E22.8CID-11 · 5A60.3PCDT · SUSDOENÇA RARA

Os bloqueadores da puberdade, também chamados de inibidores da puberdade ou bloqueadores hormonais, são medicamentos usados para adiar a puberdade em crianças. Os bloqueadores da puberdade mais comumente usados são os agonistas do hormônio liberador de gonadotrofina (GnRH), que suprimem a produção de hormônios sexuais, incluindo testosterona e estrogênio. Além de seus vários outros usos médicos, os bloqueadores da puberdade são usados por crianças trans e em questionamento para retardar o desenvolvimento de características sexuais secundárias indesejadas, modo a permitir que os jovens trans tenham mais tempo para explorar a sua identidade.

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Introdução

O que você precisa saber de cara

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Puberdade precoce central secundária em meninas, caracterizada pelo desenvolvimento sexual antes dos 8 anos, causado por tumores ou lesões no sistema nervoso central. Manifesta-se com crescimento acelerado, desenvolvimento mamário e pubarca.

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SUS: Cobertura mínimaScore: 30%
PCDT disponívelCID-10: E22.8
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🇧🇷 Atendimento SUS — Puberdade precoce central secundária no indivíduo feminino

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Isolated Premature Menarche in a 17-Month-Old: A Case Report.

The American journal of case reports2026 Mar 23

BACKGROUND Vaginal bleeding in prepubertal girls is an uncommon finding and should always prompt thorough evaluation. Puberty is a complex physiological process resulting from maturation of the hypothalamic-pituitary-gonadal axis. Precocious puberty is defined as the early onset of secondary sexual characteristics before the age of 8 years in girls. The incidence ranges from 1 in 5000 to 1 in 10 000 girls worldwide. In contrast, isolated premature menarche is a rare and benign condition characterized by vaginal bleeding without other signs of pubertal activation and remains a diagnosis of exclusion. CASE REPORT We report a 17-month-old female infant who presented with recurrent vaginal bleeding every month over the 3 months prior to admission. Physical examination showed normal external genitalia, with no signs of inflammation, trauma, foreign body, or sexual abuse. There were no secondary sexual characteristics, and growth parameters were appropriate for age. Laboratory examination revealed prepubertal basal gonadotropin levels, normal hormonal levels, normal thyroid function tests, and bone age consistent with chronological age. Platelet function testing showed hyperaggregation, considered a transient and incidental finding. Pelvic ultrasonography demonstrated the size of the uterus was consistent with the age of puberty. After exclusion of local, endocrine, and systemic causes, a diagnosis of isolated premature menarche was established. CONCLUSIONS Menstrual-like vaginal bleeding in prepubertal girls requires systematic and comprehensive examination to differentiate isolated premature menarche from other diseases. Recognition of this benign entity is important to avoid unnecessary interventions and ascertain appropriate follow-up.

#2

Case Reports: Exploring the Varied Presentations and Clinical Features of Carney Complex, A Detailed Report on Three Distinct Cases.

Journal of clinical research in pediatric endocrinology2026 Jan 05

Carney Complex (CNC) is a rare genetic disorder characterized by multiple endocrine and nonendocrine neoplasms, primarily driven by mutations in the PRKAR1A gene. This study explores the clinical heterogeneity in CNC patients, with a focus on adrenal and extra adrenal involvement and its impact on patient outcomes. We present three pediatric cases with unique clinical manifestations. Case 1: A 12-year-old female with ACTH-independent cyclic Cushing syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). The patient's condition progressed, leading to complications such as obesity, depression, and short stature, ultimately requiring bilateral adrenalectomy. Case 2: A 9-year-old male presented with an intranasal osteochondromyxoma and a large cell calcifying sertoli cell tumor. In the followup he developed hypocortisolism secondary to ACTH deficiency, with further complications including central precocious puberty and a growth hormone-secreting pituitary adenoma. Case 3: A 12-year-old female with adrenal insufficiency due to ACTH deficiency, complicated by a pituitary adenoma and a recurrent cardiac myxoma. Over time, the patient developed ACTH-independent Cushing syndrome secondary to PPNAD, necessitating bilateral adrenalectomy. Multiple fusiform aneurysms were also discovered after the recurrence of atrial myxoma. All cases highlight the absence of a consistent genotype-phenotype correlation in CNC, emphasizing the need for individualized management strategies. The findings underscore the complexity of diagnosing and treating CNC, particularly in pediatric populations, and call for further research into the underlying molecular mechanisms to develop more targeted therapies.

#3

Imaging findings in a male pediatric patient by central precocious puberty: A case report.

Radiology case reports2026 Jan

Precocious puberty (PP) refers to the early onset of secondary sexual characteristics, occurring before 8 years of age in females and 9 in males. This condition commonly results from a premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, a phenomenon identified as central precocious puberty (CPP). Central precocious puberty (CPP) in females is predominantly idiopathic, whereas in males, it is mostly caused by hypothalamic-pituitary lesions. Diagnosis is established through comprehensive clinical assessment, encompassing a thorough anamnesis from both the patient and their caregivers, detailed physical examination, and Tanner staging conducted by a pediatric endocrinologist. Neuroimaging, particularly brain MRI, is employed to detect intracranial anomalies or pituitary pathology, with pituitary microadenomas being a commonly observed finding. This report presents the case of a 5-year-old male who exhibited signs of secondary sexual development, with testicular volume consistent with Tanner stage 5 based on laboratory evaluation. Assessment of skeletal maturation revealed a significantly advanced bone age, approximating that of a 11-year-old child. The patient underwent an ultrasound examination by the results of testicular volume greater than the normal value of his age. Due to the results of the examination, the patient underwent an MRI examination of the head to find the cause by the conclusion on MRI, namely pituitary microadenoma.

#4

The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation.

Hormone research in paediatrics2026

Precocious puberty is defined as the appearance of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Central precocious puberty (CPP) is a rare condition that is diagnosed when premature activation of the hypothalamic-pituitary-gonadal axis is detected, in association with precocious breast development or testicular growth. Idiopathic CPP is historically considered to be the most common form, but in recent years defects in a small but growing number of genes regulating the timing of puberty have been identified in an increasing proportion of cases of CPP. Delta-like non-canonical Notch ligand 1 (DLK1) is understood to be one of the key genes involved in the etiology of CPP, although its mechanistic role is not yet fully understood. We identified a novel de novo variant of DLK1 (c.835C>T; p.Gln279*) in an 8-year-old girl of Bangladeshi origin. She presented with an advanced Tanner staging of B4P4A2, significantly advanced bone age (BA, 13 years), a near-adult proportioned uterus, with a history of menarche at the age of 7.4 years. Diagnosis was confirmed by raised basal luteinizing hormone concentration. She was found to have truncal obesity associated with abnormal fasting insulin levels and mildly elevated cholesterol levels. These findings are consistent with previous literature describing an association between patients with DLK1 deficiency and an impaired metabolic profile. The patient was treated for 2 years with GnRH agonists with ongoing biochemical follow-up into adolescence. This case illustrates the susceptibility to metabolic derangement for patients with mutations in DLK1 and the need for ongoing monitoring after puberty. Our summary of previously identified DLK1 variants and their metabolic consequences demonstrates the frequency of obesity, lipid abnormalities, and insulin dysregulation in this patient cohort in childhood and beyond. This knowledge can guide future clinical practice for patients with CPP patients due to DLK1 deficiency.

#5

Preventive Effects of Eclipta prostrata and Hordeum vulgare Extract Complex on Precocious Puberty in Danazol- and High-Fat Diet-Induced Rat Models.

International journal of molecular sciences2025 Nov 18

Precocious puberty, characterized by the abnormally early onset of secondary sexual development, has been increasing in prevalence worldwide. Current pharmacological treatments, including GnRH agonists, are effective but associated with adverse effects, highlighting the need for safer alternatives. In this study, we investigated the preventive effects of an herbal extract complex composed of Eclipta prostrata and Hordeum vulgare (EHEC) on precocious puberty induced by danazol administration and a high-fat diet (HFD) in rat models. EHEC delayed vaginal opening (VO) and reduced ovarian maturation in both models. Furthermore, EHEC attenuated the elevation in hypothalamic GnRH mRNA expression observed in both models, without affecting body weight. These findings suggest that EHEC modulates the hypothalamic-pituitary-gonadal axis and may serve as a potential natural therapeutic agent for the prevention of precocious puberty.

Publicações recentes

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📚 EuropePMCmostrando 146

2026

Isolated Premature Menarche in a 17-Month-Old: A Case Report.

The American journal of case reports
2025

The gut-brain axis mediates precocious puberty induced by environmentally relevant low-dose endocrine-disrupting chemical mixtures.

Frontiers in endocrinology
2026

Case Reports: Exploring the Varied Presentations and Clinical Features of Carney Complex, A Detailed Report on Three Distinct Cases.

Journal of clinical research in pediatric endocrinology
2025

Preventive Effects of Eclipta prostrata and Hordeum vulgare Extract Complex on Precocious Puberty in Danazol- and High-Fat Diet-Induced Rat Models.

International journal of molecular sciences
2025

Effect of Chinese herbal medicine on sexual characteristics of females with precocious puberty: a meta-analysis.

Frontiers in pharmacology
2025

The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial.

Trials
2026

Imaging findings in a male pediatric patient by central precocious puberty: A case report.

Radiology case reports
2025

Efficacy of combined gonadotropin-releasing hormone analogue and growth hormone therapy in girls with central precocious puberty: a systematic review and meta-analysis.

Frontiers in endocrinology
2025

Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study.

Journal of pediatric endocrinology & metabolism : JPEM
2025

Abnormal Puberty and Amenorrhea: A Review.

Pediatric annals
2025

The efficacy and safety of pharmacotherapy for girls with central precocious puberty or early normal puberty: a retrospective cohort study.

Scientific reports
2025

Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty.

Journal of endocrinological investigation
2025

Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study.

Journal of pediatric endocrinology & metabolism : JPEM
2025

Moderating role of fasting insulin on the levels of vitamin D in idiopathic central precocious puberty girls.

Biochimica et biophysica acta. Molecular basis of disease
2025

Gender differences in drug-induced precocious puberty: a real-world analysis of adverse event reports from the FDA FAERS database (2004-2024).

BMC pediatrics
2025

Interpretable XGBoost model identifies idiopathic central precocious puberty in girls using four clinical and imaging features.

BMC endocrine disorders
2025

[Secondary exposure to hormonal drugs].

Lakartidningen
2025

The Ovarian Volume in Girls Presented as Precocious Puberty.

Journal of medical ultrasound
2025

Peripheral precocious puberty in girls with McCune-Albright syndrome: a case series.

Archives of endocrinology and metabolism
2025

The US Supreme Court Joins the Debate Over Gender Dysphoria.

Clinical therapeutics
2025

Development of a simplified prediction model for diagnosing progressive central precocious puberty using clinical and pelvic ultrasound parameters.

PloS one
2025

Epidemiology of disorders associated with tall stature in childhood: A 20-year birth cohort study.

PloS one
2025

Clinical utility of ultrasonography in pediatric and adolescent gynecology: retrospective review of 1313 ultrasound examinations.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2025

Clinical Manifestations and Treatment Challenges in Infants and Children With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

The Journal of clinical endocrinology and metabolism
2024

Childhood obesity and central precocious puberty.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2025

Endocrine dysfunction in long-term survivors of pediatric head and neck rhabdomyosarcoma.

European journal of endocrinology
2024

Inflammation and oxidative stress processes in induced precocious puberty in rats.

Heliyon
2024

Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.

Frontiers in endocrinology
2025

Central precocious puberty in a toddler with hypothalamic hamartoma.

Journal of pediatric endocrinology & metabolism : JPEM
2024

Adult height in girls with idiopathic central precocious puberty treated with triptorelin.

Frontiers in endocrinology
2025

Peripheral precocious puberty secondary to severe hypothyroidism.

Archivos argentinos de pediatria
2024

Community Awareness and Knowledge About Precocious Puberty in Riyadh City, Saudi Arabia.

Cureus
2026

The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation.

Hormone research in paediatrics
2024

A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty.

Advances in therapy
2025

Abdominal imaging in precocious puberty in girls: can imaging determine onset of puberty?

Pediatric radiology
2024

[Efficacy of oral testosterone undecanoate in children with androgen insensitivity syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2024

Puberty in girls with Prader-Willi syndrome: cohort evaluation and clinical recommendations in a Latin American tertiary center.

Frontiers in endocrinology
2024

[Associations between puberty timing and cardiovascular metabolic risk factors among primary and secondary students].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
2025

Unstimulated Luteinizing Hormone for Assessment of Suppression during Treatment of Central Precocious Puberty with 6-Month Subcutaneous Leuprolide Acetate: Correlations with Clinical Response.

Hormone research in paediatrics
2024

Fifteen-minute consultation: The approach to the child with precocious puberty.

Archives of disease in childhood. Education and practice edition
2024

Endocrinopathies in a Pediatric Patient Post-anatomical Hemispherectomy for Rasmussen's Encephalitis Treatment: A Case Report.

Cureus
2024

Association of Traditional dietary pattern with early and precocious puberty: a population-based cross-sectional study.

Pediatric research
2023

The value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty.

Frontiers in endocrinology
2024

Effects of the COVID-19 pandemic on the incidence of central precocious puberty; a narrative review.

Journal of pediatric endocrinology & metabolism : JPEM
2023

Central precocious puberty: a review of diagnosis, treatment, and outcomes.

The Lancet. Child & adolescent health
2024

Differentiation of Idiopathic Central Precocious Puberty From Premature Thelarche Using Principal Component Analysis.

The Journal of clinical endocrinology and metabolism
2023

Efficacy and Safety of Triptorelin 3-Month Formulation in Chinese Children with Central Precocious Puberty: A Phase 3, Open-Label, Single-Arm Study.

Advances in therapy
2024

Premature Thelarche: An Updated Review.

Current pediatric reviews
2024

Clinical course of peripheral precocious puberty in girls due to autonomous ovarian cysts.

Clinical endocrinology
2023

[Further progress of the etiology,diagnosis and treatment of peripheral precocious puberty].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
2023

Mayer-Rokitansky-Küster-Hauser syndrome with idiopathic central precocious puberty: a case report.

Translational pediatrics
2023

Brain and eye involvement in McCune-Albright Syndrome: clinical and translational insights.

Frontiers in endocrinology
2023

McCune-Albright Syndrome: A Case Report and Review of Literature.

International journal of molecular sciences
2023

Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty.

Scientific reports
2023

Hypothalamic hamartoma: a cause of precocious puberty.

BMJ case reports
2023

Precocious puberty in relation to the COVID-19 pandemic. A survey among Argentine pediatric endocrinologists.

Archivos argentinos de pediatria
2023

Current Pubertal Development in Chinese Children and the Impact of Overnutrition, Lifestyle, and Perinatal Factors.

The Journal of clinical endocrinology and metabolism
2023

A 12-Year-Old Girl with Juvenile Granulosa Cell Tumor of the Ovary, Presenting with Adolescent Hyperprolactinemia, Galactorrhea, and Amenorrhea.

The American journal of case reports
2022

Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis.

Nutrients
2022

A review of adverse events in animals and children after secondary exposure to transdermal hormone-containing medicinal products.

Veterinary record open
2022

[OPTIC DISC EDEMA IN McCUNE-ALBRIGHT SYNDROME].

Harefuah
2022

Daughters of polycystic ovary syndrome pregnancies and androgen levels in puberty: a Meta-analysis.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
2022

Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats.

International journal of environmental research and public health
2022

The value of urinary gonadotropins in the diagnosis of central precocious puberty: a meta-analysis.

BMC pediatrics
2022

Has the Frequency of Precocious Puberty and Rapidly Progressive Early Puberty Increased in Girls During the COVID-19 Pandemic?

Journal of clinical research in pediatric endocrinology
2025

Central precocious puberty in children after COVID-19 outbreak: a single-center retrospective study.

Minerva pediatrics
2022

Exposure to antibiotics and precocious puberty in children: A school-based cross-sectional study in China.

Environmental research
2022

Incidental pineal gland cyst in girls with early onset of puberty.

Italian journal of pediatrics
2022

[Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence].

Archivos argentinos de pediatria
2021

An open label, multicenter clinical trial that investigated the efficacy and safety of leuprorelin treatment of central precocious puberty in Chinese children.

Medicine
2021

Feminizing adrenocortical adenoma in a girl from a resource-limited setting: a case report.

Journal of medical case reports
2024

Can Multi-Dimensional Voice Program (MDVP) Be Used as A Diagnostic Tool for Precocious Puberty?

Journal of voice : official journal of the Voice Foundation
2021

[Clinical guidelines «Precocious puberty»].

Problemy endokrinologii
2023

Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty.

Journal of clinical research in pediatric endocrinology
2021

The role of pelvic ultrasound for the diagnosis and management of central precocious puberty: An update.

Acta bio-medica : Atenei Parmensis
2021

Effect of Decaffeinated Green Tea Polyphenols on Body Fat and Precocious Puberty in Obese Girls: A Randomized Controlled Trial.

Frontiers in endocrinology
2021

Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty.

Stem cell research
2021

McCune-Albright syndrome, a rare form of precocious puberty: Diagnosis, treatment, and follow-up.

Archivos argentinos de pediatria
2021

The relationship between body weight and dietary habits with respect to the timing of puberty among saudi children and adolescents.

Annals of African medicine
2022

Growth in Transgender/Gender-Diverse Youth in the First Year of Treatment With Gonadotropin-Releasing Hormone Agonists.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine
2021

Association of Obesity and Body Fat Percentage with Pubertal State in Six- to Nine-Year-Old Chinese Females.

Childhood obesity (Print)
2022

Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.

Journal of pediatric hematology/oncology
2021

Diagnosis and management of precocious sexual maturation: an updated review.

European journal of pediatrics
2021

Central precocious puberty in a girl with LEGIUS syndrome: an accidental association?

Italian journal of pediatrics
2021

Short-term effects of gonadotropin-releasing hormone analogue treatment on leptin, ghrelin and peptide YY in girls with central precocious puberty.

Journal of pediatric endocrinology & metabolism : JPEM
2020

Machine learning identifies girls with central precocious puberty based on multisource data.

JAMIA open
2021

Prevalence of precocious puberty among Chinese children: a school population-based study.

Endocrine
2021

Congenital Blindness and Autism Spectrum Disorder.

Journal of developmental and behavioral pediatrics : JDBP
2020

Serum Levels of Thyroid Stimulating Hormone and Luteinizing Hormone Are Decreased in Girls with Central Precocious Puberty after 12-Month GnRH Agonist Treatment.

The Tohoku journal of experimental medicine
2020

Clinical impact of hypothalamic-pituitary disorders after conformal radiation therapy for pediatric low-grade glioma or ependymoma.

Pediatric blood & cancer
2020

Van Wyk-Grumbach syndrome and oligosyndactyly in a 6-year-old girl: a case report.

Journal of medical case reports
2020

[The diagnostic evaluation of tall stature in children].

Nederlands tijdschrift voor geneeskunde
2020

Methodology for the development of the Clinical guideline for the diagnosis and treatment of precocious puberty.

Boletin medico del Hospital Infantil de Mexico
2020

Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report.

International journal of surgical pathology
2020

McCune-Albright syndrome and type 1 diabetes mellitus: a novel presentation.

Annals of the New York Academy of Sciences
2020

Age at menarche associated with subsequent educational attainment and risk-taking behaviours: the Pelotas 1982 Birth Cohort.

Annals of human biology
2020

Relationships of Lead, Mercury and Cadmium Levels with the Timing of Menarche among Korean Girls.

Child health nursing research
2019

McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation - a case report.

Medicine
2019

Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty.

International journal of endocrinology
2019

Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty.

Annals of pediatric endocrinology & metabolism
2019

Is menarche occuring earlier among Lebanese girls?

Revue d'epidemiologie et de sante publique
2020

Effects of 5-Hydroxymethylfurfural on Pubertal Development of Female Wistar Rats.

Journal of clinical research in pediatric endocrinology
2019

Towards a Rational and Efficient Diagnostic Approach in Children Referred for Tall Stature and/or Accelerated Growth to the General Paediatrician.

Hormone research in paediatrics
2019

The diagnosis of androgenetic alopecia in children: Considerations of pathophysiological plausibility.

The Australasian journal of dermatology
2019

Update on Precocious Puberty in Girls.

Journal of pediatric and adolescent gynecology
2019

Central precocious puberty, functional and tumor-related.

Best practice & research. Clinical endocrinology & metabolism
2019

A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
2018

Möbius syndrome associated with obesity and precocious puberty.

BMJ case reports
2019

Improvement of Hypothalamic Hamartoma-Related Psychiatric Disorder After Stereotactic Laser Ablation: Case Report and Review of Literature.

World neurosurgery
2018

Chiari I Malformation and Basilar Invagination in Fibrous Dysplasia: Prevalence, Mechanisms, and Clinical Implications.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2018

Two rare forms of congenital adrenal hyperplasia, 11β hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.

Hormones (Athens, Greece)
2018

Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome.

The Journal of clinical endocrinology and metabolism
2018

[Diffuse hypertrichosis revealing non-classical congenital adrenal hyperplasia].

Annales de dermatologie et de venereologie
2018

Evaluation of basal sex hormone levels for activation of the hypothalamic-pituitary-gonadal axis.

Journal of pediatric endocrinology & metabolism : JPEM
2017

Secondary aneurysmal bone cyst in McCune-Albright syndrome.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
2017

Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats.

Evidence-based complementary and alternative medicine : eCAM
2017

Van Wyk-Grumbach Syndrome with Kocher-Debré-Sémélaigne Syndrome: Case Report of a Rare Association.

European thyroid journal
2017

Central Precocious Puberty Secondary to Adrenocortical Adenoma in a Female Child: Case Report and Review of the Literature.

Journal of pediatric and adolescent gynecology
2017

Association study of LIN28B in girls with precocious puberty.

Journal of pediatric endocrinology & metabolism : JPEM
2017

[Endocrine and metabolic features of female children with Prader-Willi syndrome: an analysis of 4 cases].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2017

Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China.

BMJ open
2017

[Management of premature breast or pubic hair development in young girls].

La Revue du praticien
2017

Meta-Analysis of Paediatric Patients with Central Precocious Puberty Treated with Intramuscular Triptorelin 11.25 mg 3-Month Prolonged-Release Formulation
.

Hormone research in paediatrics
2017

Pure endoscopic management of epileptogenic hypothalamic hamartomas.

Neurosurgical review
2016

An 11-month-old girl with central precocious puberty caused by hypothalamic hamartoma.

Annals of pediatric endocrinology & metabolism
2017

Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial.

Food & function
2017

[Puberty Suppression for Adolescents with Gender Dysphoria A Japanese Perspective].

Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
2016

[Peripheral precocious puberty].

Ceska gynekologie
2016

Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty.

Annals of pediatric endocrinology & metabolism
2016

A Case of Primary Hypogonadism with Features of Albright's Syndrome.

Journal of reproduction & infertility
2016

[Psychopathology related to women pubertal precocity].

L'Encephale
2016

Prepubertal Gynecomastia Due to Indirect Exposure to Nonformulary Bioidentical Hormonal Replacement Therapy: A Case Report.

The Journal of reproductive medicine
2016

[Gender specific associations between early puberty and behavioral and emotional characteristics in children].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2016

Psychosocial and respiratory disease related to severe bladder dysfunction and non-monosymptomatic enuresis.

Journal of pediatric urology
2016

Treatment of Peripheral Precocious Puberty.

Endocrine development
2016

Sexual Precocity--Genetic Bases of Central Precocious Puberty and Autonomous Gonadal Activation.

Endocrine development
2015

[EATING DISORDERS IN PEDIATRIC AGE: A BOOM PATHOLOGY].

Nutricion hospitalaria
2015

Management of Ovarian Cancer In Younger Women.

Reviews on recent clinical trials
2015

A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty.

Pediatric research
2015

Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study.

Hormone research in paediatrics
2015

A Case Report of Adrenocortical Adenoma Mimicking Congenital Adrenal Hyperplasia in a Young Girl.

Medicine
2015

Postinjection Muscle Fibrosis from Lupron.

Case reports in pediatrics
2015

Use of a Gonadotropin-releasing Hormone Analog to Treat Idiopathic Central Precocious Puberty Is Not Associated with Changes in Bone Structure in Postmenarchal Adolescents.

Journal of pediatric and adolescent gynecology
2015

[Associations between adverse childhood experiences with early puberty timing and possible gender difference].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2015

Efficacy and safety of domestic leuprorelin in girls with idiopathic central precocious puberty: a multicenter, randomized, parallel, controlled trial.

Chinese medical journal
2015

Endocrine sequelae beyond 10 years in survivors of medulloblastoma.

Clinical endocrinology

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Puberdade precoce central secundária no indivíduo feminino.

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Puberdade precoce central secundária no indivíduo feminino

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Isolated Premature Menarche in a 17-Month-Old: A Case Report.
    The American journal of case reports· 2026· PMID 41871008mais citado
  2. Case Reports: Exploring the Varied Presentations and Clinical Features of Carney Complex, A Detailed Report on Three Distinct Cases.
    Journal of clinical research in pediatric endocrinology· 2026· PMID 41486943mais citado
  3. Imaging findings in a male pediatric patient by central precocious puberty: A case report.
    Radiology case reports· 2026· PMID 41142856mais citado
  4. The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation.
    Hormone research in paediatrics· 2026· PMID 39419009mais citado
  5. Preventive Effects of Eclipta prostrata and Hordeum vulgare Extract Complex on Precocious Puberty in Danazol- and High-Fat Diet-Induced Rat Models.
    International journal of molecular sciences· 2025· PMID 41303642mais citado
  6. The gut-brain axis mediates precocious puberty induced by environmentally relevant low-dose endocrine-disrupting chemical mixtures.
    Front Endocrinol (Lausanne)· 2025· PMID 41659330recente
  7. The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial.
    Trials· 2025· PMID 41291865recente
  8. Efficacy of combined gonadotropin-releasing hormone analogue and growth hormone therapy in girls with central precocious puberty: a systematic review and meta-analysis.
    Front Endocrinol (Lausanne)· 2025· PMID 41127510recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:650082(Orphanet)
  2. MONDO:0958355(MONDO)
  3. Puberdade Precoce Central(PCDT · Ministério da Saúde)
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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