Raras
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Tumor misto das células germinativas do sistema nervoso central
ORPHA:252021CID-10 · C72.9CID-11 · 2A00.1YDOENÇA RARA

A pele, cútis ou tez, em anatomia, é o órgão integrante do sistema tegumentar, que tem por principais funções a proteção dos tecidos subjacentes, regulação da temperatura somática e ainda conter terminações nervosas sensitivas.

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Introdução

O que você precisa saber de cara

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Neoplasia rara originada de células germinativas ectópicas no SNC, apresentando componentes histológicos variados (teratoma, disgerminoma, coriocarcinoma, etc.). Manifesta-se com sintomas neurológicos progressivos dependendo da localização e tamanho.

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SUS: Sem cobertura SUSScore: 0%
CID-10: C72.9
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Últimos 10 anos200publicações
Pico202226 papers
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20202017Hoje · 2026🧪 1990Primeiro ensaio clínico📈 2022Ano de pico
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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Trends in net survival for patients with brain tumors in Japan, 2000-14 (CONCORD-3).

Japanese journal of clinical oncology2026 Mar 20

Brain tumors are a serious health issue, and survival is an effective indicator of how the healthcare system manages them. We examined net survival trends for patients diagnosed with a primary brain tumor during 2000-2014 in Japan, using data from 16 regional population-based cancer registries participating in the CONCORD-3 study. We included patients aged 15-99 years, with follow-up completed either 5 years after diagnosis or up to 31 December, 2014. We estimated 5-year net survival by age group and morphological subtype using the Pohar Perme estimator, and age-standardized with International Cancer Survival Standard weights. Five-year net survival for brain tumors increased from 27.9% for patients diagnosed during 2000-2004 to 46.3% in 2010-2014. During 2010-2014, 5-year net survival for astrocytic tumors was 22.3%, but ~90% for neuronal and mixed neuro-glial tumors, germ cell tumors, and other specified tumors. Five-year net survival reached 62.1% for oligodendroglial and oligoastrocytic tumors. Five-year net survival for brain tumors in Japan improved during 2000-2014, with remarkable variations by morphologic type. Survival improved for all age groups, and particularly for younger patients, highlighting the need for enhanced survivorship care. Japan's focus on comprehensive data collection and supportive care for longer-term survivors remains key for further progress. When comparedinternationally, Japan's gains sit at the higher end of reported survival ranges, underscoring how robust registry infrastructure and equitable access to care could inform strategies for brain tumor care.

#2

Stereotactic intracranial implantation of patient-derived glioblastoma cells in rats: A xenograft modeling approach.

Journal of neuroscience methods2026 Mar

Glioblastoma (GBM) is an aggressive primary brain cancer with a poor prognosis. Preclinical animal models are essential for studying GBM pathophysiology and therapy; however, existing models often fail to fully capture the tumor's heterogeneity and the partially immunodeficient microenvironment critical to its progression. We developed a novel GBM model using the stereotactic implantation of primary patient-derived GBM cells from various donors into the brains of rats subjected to transient, partial immune suppression. This model combines the biological heterogeneity of patient-derived cells with the anatomical advantages of a larger rodent brain, improving spatial tumor localization. The use of a mixed primary cell population better recapitulates human GBM heterogeneity. Furthermore, the model's partially preserved immune environment allows for the investigation of tumor-immune interactions. Unlike fully immunodeficient models, our approach maintains a more physiologically relevant, partially intact immune system. Compared to murine models, the rat brain offers superior spatial resolution for tumor analysis and intervention. This method provides a reliable and translational platform that enhances the fidelity of preclinical GBM research. It offers an improved tool for drug evaluation and the development of personalized therapeutic strategies by more accurately mimicking the complex and heterogeneous nature of human GBM.

#3

A functionally relevant model for interrogating brain tumor-endothelial cell interactions.

Journal of neuroscience methods2026 Mar

Intercellular interactions, particularly those between tumor cells and the surrounding vasculature, are central to the biology of the tumor microenvironment. Approaches for studying these interactions often rely on limited patient samples or time- and resource-intensive xenograft tissues in combination with histological or single-cell omics profiling. While informative, these models capture only static snapshots and limit mechanistic interrogation. Studying the mechanisms behind these interactions requires viable co-culture models for culturing different cell types together in vitro, while preserving the phenotypic integrity of each cell type. To achieve this, we developed and validated optimal in vitro culture conditions to support the co-culture of human Group 3 medulloblastoma (G3 MB) cells and microvascular brain endothelial cells (BECs) as an ideal screening model for mechanistic and interventional studies. Supported by a new optimized 1:1 mixed media formulation, this model preserves native cellular morphology and phenotypic characteristics. When cultured alone in the new optimized media, G3 MB cells retained expression of stemness markers (SOX2 & OTX2), self-renewal capacity, and undifferentiated morphology, while BECs retained tight junction formation and migratory behavior. This co-culture platform permits real-time, dynamic, and mechanistic studies of tumor-endothelial cell interactions, overcoming the limitations of fixed-tissue analyses and facilitating precise experimental manipulation. This well-characterized model provides a physiologically and functionally relevant platform for further dissecting the reciprocal interactions present between various brain cancer cells and vascular endothelial cells, supporting the development of targeted therapeutic strategies and advancing our understanding of brain tumor biology.

#4

Vaccine immunotherapy for glioblastoma: How can previous attempts guide us?

Experimental neurology2026 Feb

Yearly, glioblastoma (GBM) is the cause of death of thousands of people in the US. It is paradoxically one of the most lethal and frequent central nervous system malignancies, occupying a unique position in cancer research. Among various attempted management strategies, vaccine immunotherapy has undergone multiple investigations, with heterogenous results. A systematic review was undertaken on two databases to identify studies evaluating vaccine immunotherapy survival response in glioblastoma or high-grade malignant glioma. A subgroup meta-analysis of overall survival hazard ratios, a meta-regression and multi-trial Kaplan-Meier curves were delineated via reconstructed survival data. 537 studies were found, and 36 were eligible for inclusion. Out of these, 12 had comparable arms for meta-analysis. There was a 49 % [26 %; 64 %] death hazard reduction in the pooled analysis. Only the dendritic cell-based vaccines showed benefit when groups were tested separately. The multi-trial curve suggested a disparity among different approaches. For newly diagnosed GBM, the median overall survival was 18.9 months, ranging from 15.36 to 31.46 months. For recurrent GBM or mixed trials, the median overall survival was 13.9 months, ranging from 9.71 to 15.53 months. Vaccine immunotherapy for GBM appears to depend on dendritic cells to achieve significant improvements in survival. The incorporation of innate immunity modulators such as GM-CSF and Poly-ICLC, along with stratification by MGMT-methylation, are promising. Although an expressive HR reduction was achieved, there are still primary scientific validity concerns, the residual hazard leads to a reserved prognosis and should be addressed by multimodal treatment approaches.

#5

The Endoscopic ExtraForaminal TransChoroid (EFTC) Approach in the Management of Pineal Tumors: Gross Total Resection through a Single Burr Hole.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026 Mar 10

Pineal region tumors pose a significant surgical challenge due to their deep location and proximity to critical neurovascular structures. Endoscopic techniques, particularly the transchoroid approach, have expanded the possibilities for minimally invasive access to the posterior third ventricle. In select cases, this route may not only allow simultaneous biopsy and third ventriculostomy but also meaningful tumour resection while limiting morbidity. We report the case of an 11-year-old male presenting with headache, drowsiness, vomiting and diplopia. Imaging demonstrated a heterogeneous pineal mass with features suggestive of teratoma. Serum markers revealed markedly elevated β-HCG with normal AFP. The radiological picture coupled with the tumour markers was consistent with a mixed malignant germ cell tumour. An endoscopic third ventriculostomy (ETV) and endoscopic extraforaminal transchoroid (EFTC) approach were planned through a single burr hole with the aim of cerebrospinal fluid (CSF) diversion, providing a tissue sample and debulking if possible and appropriate. The identification of mature teratomatous components on smear and a favorable dissection plane enabled and justified gross total resection through the single burr hole. Histopathology confirmed mature and immature teratomatous tissue with a 5-10% germinomatous component. The postoperative course was uneventful, and the patient completed chemotherapy followed by proton beam radiotherapy, remaining recurrence-free at the latest follow-up of over two years. This case represents the first reported gross total resection (GTR) of a pineal tumour achieved via an endoscopic EFTC approach and highlights its potential as a safe and effective minimally invasive route for lesions in the posterior third ventricle, enabling complete resection in select patients.

Publicações recentes

Ver todas no PubMed

📚 EuropePMCmostrando 196

2026

Trends in net survival for patients with brain tumors in Japan, 2000-14 (CONCORD-3).

Japanese journal of clinical oncology
2026

The Endoscopic ExtraForaminal TransChoroid (EFTC) Approach in the Management of Pineal Tumors: Gross Total Resection through a Single Burr Hole.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Simultaneous occurrence of bilateral retroperitoneal neuroblastoma and bifocal malignant mixed germ cell tumor in a pediatric patient with 16p11.2 microdeletion syndrome: a case report.

Frontiers in endocrinology
2026

Therapeutic vaccination for glioblastoma elicited by retargeted oncolytic herpes virus.

Journal for immunotherapy of cancer
2026

STAN, a computational framework for inferring spatially informed transcription factor activity.

Nucleic acids research
2026

When germ cell tumors defy gender: three cases of primary mediastinal presentation in women.

Indian journal of thoracic and cardiovascular surgery
2026

Longitudinal prediction of T and B lymphocyte kinetics following brain irradiation in rodents.

Clinical and experimental immunology
2026

Stereotactic intracranial implantation of patient-derived glioblastoma cells in rats: A xenograft modeling approach.

Journal of neuroscience methods
2026

A functionally relevant model for interrogating brain tumor-endothelial cell interactions.

Journal of neuroscience methods
2025

Elevation of hCG in CSF in pinealoblastoma: a pitfall rescued by pathological examination.

Acta neuropathologica communications
2026

Vaccine immunotherapy for glioblastoma: How can previous attempts guide us?

Experimental neurology
2025

Carbon ion combined photon radiotherapy induces ferroptosis via NCOA4-mediated ferritinophagy in glioblastoma.

Redox biology
2025

Role of mixed reality in the workflow of complex neurooncological surgeries: a case analysis in thalamic surgery.

Acta neurochirurgica
2025

Molecular architecture of language-related cortical areas revealed by integrative proteomic and connectome analyses.

Clinical and translational medicine
2025

[Glymphatic system in health and disease: a narrative review].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2026

Optic Chiasm and Bilateral Optic Nerve Oligodendroglioma in A 29-Month-Old German Shepherd.

Veterinary ophthalmology
2025

Immune profiling of pediatric germ cell tumors identifies key cell populations and novel therapeutic targets.

Frontiers in immunology
2025

Endoscopic endonasal approaches for resection of suprasellar pituitary neuroendocrine tumors: a novel classification based on the optic chiasm and operative nuances.

BMC surgery
2025

RANO 2.0: critical updates and practical considerations for radiological assessment in neuro-oncology.

Japanese journal of radiology
2025

Pediatric midbrain tectal glioneuronal tumor with intratumoral hemorrhage: a case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Primary intracranial immature teratoma in an adult woman: case report and literature review.

BMC women's health
2025

The Application of Quasi-Steady-State Chemical Exchange Saturation Transfer Imaging in the Visualization of Glioma Infiltration and the Optimal Extent of Resection Establishment.

Journal of magnetic resonance imaging : JMRI
2025

Early and late structural brain changes after radiation therapy: an MRI study in glioma patients.

Journal of neuro-oncology
2025

Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study.

Acta neurochirurgica
2025

A Primary Spinal Intramedullary Mixed Germ Cell Tumor: A Case Report and Literature Review.

NMC case report journal
2025

Immunomodulatory role of exosome-derived content in pediatric medulloblastoma: a molecular subgroup perspective.

Human cell
2025

Long-term outcome of cerebrospinal fluid diversion in patients with intracranial germinoma at Ramathibodi Hospital.

Langenbeck's archives of surgery
2025

Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma.

Science advances
2024

[Ganglioglioma with an atypical histopathological phenotype or a new entity of the LEAT group?].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma.

Cancer research
2024

High-Grade Thalamic Glioma: Case Report with Literature Review.

Medicina (Kaunas, Lithuania)
2024

Study protocol for a multicentre randomised controlled trial evaluating the efficacy of an online yoga intervention in high-grade glioma patients and their caregivers: the YINOTA-O-trial.

BMJ open
2025

The Use of Diffusion Tensor Imaging in the Differentiation and Surgical Planning of Suprasellar Hypothalamic-Opticochiasmatic Glioma and Craniopharyngioma in Children.

World neurosurgery
2024

Diffuse leptomeningeal glioneuronal tumor with distinct neuronal and glial components but identical diagnostic molecular and genetic features.

Neuropathology : official journal of the Japanese Society of Neuropathology
2024

Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results.

Journal of neuro-oncology
2024

Clinical effects of neuroendoscopic infratentorial supracerebellar approach surgical technique for resecting pineal tumors: a retrospective study.

Neuro-Chirurgie
2024

Brain network topology and its cognitive impact in adult glioma survivors.

Scientific reports
2025

Prognostic implications of distinctive imaging characteristics in primary intracranial germ cell tumors: A retrospective analysis.

Journal of the Formosan Medical Association = Taiwan yi zhi
2024

Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells.

PloS one
2024

CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.

Acta neuropathologica communications
2024

Induction of SK-MEL-28 Invasion by Brain Cortical Cell-Conditioned Medium Through CXCL10 Signaling.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
2023

Primary central nervous system tumors survival in children in ten Colombian cities: a VIGICANCER report.

Frontiers in oncology
2024

High-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity.

AJNR. American journal of neuroradiology
2024

Endoscopic Transsphenoidal Resection of Cystic Third Ventricular Craniopharyngioma with Cystocisternal Fenestration.

World neurosurgery
2024

Clinicopathological spectrum of central nervous system germ cell tumors: A single-institution retrospective study.

Indian journal of pathology & microbiology
2024

Clinicopathological analysis of rosette-forming glioneuronal tumors.

Diagnostic pathology
2024

Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: A French retrospective study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2024

Microsurgical Resection of Giant Radio-Induced Cavernous Malformation: 2- Dimensional Video.

World neurosurgery
2024

A novel radiological classification of midbrain pilocytic astrocytomas and its implication for surgical management: a single-institution experience of 57 cases.

Journal of neurosurgery
2024

Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma.

International journal of radiation oncology, biology, physics
2024

Glioma Tumor Grading Using Radiomics on Conventional MRI: A Comparative Study of WHO 2021 and WHO 2016 Classification of Central Nervous Tumors.

Journal of magnetic resonance imaging : JMRI
2023

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.

Molecular brain
2024

Extragonadal Germ Cell Tumors: A Single Institution Experience with Clinicopathological Correlation.

International journal of surgical pathology
2024

Cytopathology of glioneuronal and neuronal tumours with histological correlations.

Cytopathology : official journal of the British Society for Clinical Cytology
2023

Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children.

Journal of neuropathology and experimental neurology
2023

"A tumour registry initiative".

World neurosurgery: X
2023

A rare tumor in the sellar region: ganglioglioma, a case report and a general overview.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

Intracranial Germinoma-Association between Delayed Diagnosis, Altered Clinical Manifestations, and Prognosis.

Cancers
2023

Staged Gamma Knife radiosurgery for a rosette-forming glioneuronal tumor of the fourth ventricle: a case report.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

The effect of different brain lesions on the reorganization of language functions within the dominant hemisphere assessed with task-based BOLD-fMRI.

La Radiologia medica
2023

The Consistence of Dynamic Contrast-Enhanced MRI and Filter-Exchange Imaging in Measuring Water Exchange Across the Blood-Brain Barrier in High-Grade Glioma.

Journal of magnetic resonance imaging : JMRI
2023

Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy.

Frontiers in immunology
2023

H3 G34-mutant high-grade gliomas: integrated clinical, imaging and pathological characterisation of a single-centre case series.

Acta neurochirurgica
2023

Treatment of Pediatric Low-Grade Gliomas.

Current neurology and neuroscience reports
2023

Diffuse Leptomeningeal Glioneuronal Tumors: A Case Series of Five Patients with Parenchymal Forms and an Analysis of the Diagnostic Challenges, Treatment Options and Outcomes.

Current medical imaging
2023

The Recurrent-Specific Regulation Network of Prognostic Stemness-Related Signatures in Low-Grade Glioma.

Disease markers
2022

The immune landscape of high-grade brain tumor after treatment with immune checkpoint blockade.

Frontiers in immunology
2023

Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report.

Brain tumor pathology
2023

The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2023

Cortical mapping in multilinguals undergoing awake brain surgery for brain tumors: Illustrative cases and systematic review.

Neuropsychologia
2023

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.

Neoplasia (New York, N.Y.)
2022

[New pathological classification and clinical implications of pituitary neuroendocrine tumors of the 2022 WHO version].

Zhonghua yi xue za zhi
2023

Pure endoscopic resection of pineal region tumors through supracerebellar infratentorial approach with 'head-up' park-bench position.

Neurological research
2022

Endoscopic aqueductal membrane fenestration was effective for intractable hydrocephalus after removal of a nongerminomatous germ cell tumor exhibiting growing teratoma syndrome: a case report.

BMC pediatrics
2022

High-grade desmoplastic infantile astrocytoma in a 1-year-old child with Down's syndrome: a case report.

Journal of medical case reports
2022

Volumetric changes in gray matter after radiotherapy detected with longitudinal magnetic resonance imaging in glioma patients.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2022

Supracerebellar Infratentorial Approach for a Malignant Pineal Region Tumor Mimicking a Cavernous Malformation.

World neurosurgery
2022

Magnetic Resonance Imaging Scans of Cervical Spinal Cord Ependymoma with Changing Radiological Features over a Short Period of Time.

World neurosurgery
2023

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review.

Internal medicine (Tokyo, Japan)
2022

Quantifying the post-radiation accelerated brain aging rate in glioma patients with deep learning.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2022

Malignant oligoastrocytoma in the spinal cord of a cat.

The Journal of veterinary medical science
2022

Agricultural activities and risk of central nervous system tumors among French farm managers: Results from the TRACTOR project.

International journal of cancer
2022

Germ cell tumors with neuroglial differentiation do not show molecular features akin to their central nervous system counterpart: experience from extra-gynecological sites.

Virchows Archiv : an international journal of pathology
2022

Uncommon Glioneuronal Tumors: A Radiologic and Pathologic Synopsis.

AJNR. American journal of neuroradiology
2022

[The value of CXorf67 and H3K27me3 for diagnosing germ cell tumors in central nervous system].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2022

Radiographic Response Assessment Strategies for Early-Phase Brain Trials in Complex Tumor Types and Drug Combinations: from Digital "Flipbooks" to Control Systems Theory.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2022

Diaph3 underlines tumor cell heterogeneity in glioblastoma with implications for treatment modalities resistance.

Journal of neuro-oncology
2022

Gliosarcoma with osteosarcomatous component: A case report and short review illustration.

Pathology, research and practice
2022

Malignant Melanoma of the Brainstem: A Unicorn Not a Popcorn.

Neurology India
2022

Diffuse leptomeningeal glioneuronal tumor without KIAA1549-BRAF fusion and 1p detection: a case report and review of literature.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2022

Red blood cell distribution width in glioblastoma.

Clinical neurology and neurosurgery
2021

MRI features of an atypical case of extraventricular neurocytoma: A case report.

Medicine
2021

A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes.

CNS oncology
2022

Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report.

Cancer reports (Hoboken, N.J.)
2021

Magnetic resonance imaging findings and antemortem cytologic diagnosis of intramedullary spinal cord ependymoma in a dog.

Journal of the American Veterinary Medical Association
2022

Staged operations for a hypervascular mixed germ cell tumor with growing teratoma syndrome: a case report.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2022

Association Between Brain Substructure Dose and Cognitive Outcomes in Children With Medulloblastoma Treated on SJMB03: A Step Toward Substructure-Informed Planning.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2022

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.

Neuro-oncology
2021

Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).

Journal of neuro-oncology
2021

Resection of a Dumbbell-Shaped Facial Nerve Schwannoma With Preservation of Facial Nerve Function Through the Extended Middle Fossa Approach: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2022

Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.

Journal of neurosurgery
2024

Papillary glioneuronal tumor: a case report of the cerebral aqueduct and review of literature.

British journal of neurosurgery
2022

Memory recovery in relation to default mode network impairment and neurite density during brain tumor treatment.

Journal of neurosurgery
2021

Extraventricular neurocytomas: a systematic review of the literature in the pediatric population.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2021

Altered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances.

European journal of endocrinology
2021

The rosette-forming glioneuronal tumor mimicked cerebral cysticercosis: a case report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Imaging diagnosis of basal ganglia germ cell tumors: subtype features subtype imaging features of GCTs.

The British journal of radiology
2021

DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study.

Clinical neuroradiology
2021

A case of a rosette-forming glioneuronal tumor with clinicopathological features of a dysembryoplastic neuroepithelial tumor and fibroblast growth factor receptor 1 internal tandem duplication.

Brain tumor pathology
2021

A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.

Pediatric blood & cancer
2021

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.

Acta neuropathologica
2021

Simultaneous intracranial and testicular germ cell tumors: illustrative case.

Journal of neurosurgery. Case lessons
2021

Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression.

Journal of neuroscience research
2021

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation.

Head and neck pathology
2021

Successful treatment of non-midline primary malignant germ cell tumors with yolk sac components in neonates: report of 2 cases.

Journal of neurosurgery. Pediatrics
2020

Pineal teratoma with nephroblastic component in a newborn male: Case report and review of the literature.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2020

Klinefelter syndrome and germ cell tumors: review of the literature.

International journal of pediatric endocrinology
2020

High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI.

NeuroImage. Clinical
2021

The development of numerous radiation-induced cavernous malformations in a germ cell tumor patient: A case report.

Current problems in cancer
2021

Noradrenaline protects neurons against H2 O2 -induced death by increasing the supply of glutathione from astrocytes via β3 -adrenoceptor stimulation.

Journal of neuroscience research
2021

Multiparametric-MRI-Based Radiomics Model for Differentiating Primary Central Nervous System Lymphoma From Glioblastoma: Development and Cross-Vendor Validation.

Journal of magnetic resonance imaging : JMRI
2021

Large Congenital Facial Teratoma Associated With Neurological Migration Disorder (Polymicrogyria) and Absent Corpus Callosum.

The Journal of craniofacial surgery
2020

Height after photon craniospinal irradiation in pediatric patients treated for central nervous system embryonal tumors.

Pediatric blood & cancer
2020

Pituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".

The Journal of clinical endocrinology and metabolism
2020

Mixed Sparsely Granulated Lactotroph and Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor Expands the Spectrum of Neuroendocrine Neoplasms in Ovarian Teratomas: the Role of Pituitary Neuroendocrine Cell Lineage Biomarkers.

Endocrine pathology
2020

A Rare Case of Schwannoma Arising from the Dura Mater of the Petrosal Surface in the Posterior Cranial Fossa.

World neurosurgery
2021

Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases.

International journal of surgical pathology
2020

In Vivo Validation of the BIANCA Biophysical Model: Benchmarking against Rat Spinal Cord RBE Data.

International journal of molecular sciences
2020

Nose-to-brain drug delivery system with ligand/cell-penetrating peptide-modified polymeric nano-micelles for intracerebral gliomas.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2020

Novel Diagnostic Methods and Posttreatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.

Neurosurgery
2020

[A Case of Primary Intracranial Malignant Melanoma Mimicking a Traumatic Brain Contusion].

No shinkei geka. Neurological surgery
2021

Dysembryoplastic neuroepithelial tumour in the cerebellum: case report and literature review.

British journal of neurosurgery
2021

Pituitary Function after High-Dose 177Lu-DOTATATE Therapy and Long-Term Follow-Up.

Neuroendocrinology
2020

Imaging of Neuronal and Mixed Glioneuronal Tumors.

Journal of computer assisted tomography
2020

Novel and recurrent germline mutations in the VHL gene in 5 Arab patients with Von Hippel-Lindau disease.

Cancer genetics
2020

Low-grade developmental and epilepsy associated brain tumors: a critical update 2020.

Acta neuropathologica communications
2020

Oncolytic HSV-Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research
2020

Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968-2016.

International archives of occupational and environmental health
2019

Automatic Histogram Specification for Glioma Grading Using Multicenter Data.

Journal of healthcare engineering
2020

Diffuse Leptomeningeal Glioneuronal Tumor: A Unique Leptomeningeal Tumor Entity.

World neurosurgery
2020

Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors.

Journal of neuropathology and experimental neurology
2020

Microneurosurgical Removal of a Globus Pallidus Tumor With Cottonoid-Guided Intraoperative Ultrasonography: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2020

Imaging and Radiologic-Pathologic Correlation in Granular Cell Astrocytomas: Report of 2 Cases.

World neurosurgery
2020

Histopathological features of malignant craniopharyngioma: Case report and literature review.

Clinical neuropathology
2020

Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model.

Radiology
2019

Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways.

Journal of neuropathology and experimental neurology
2019

Adult-Onset Mixed Germ Cell Tumor Composed Mainly of Yolk Sac Tumor Around the Pineal Gland: A Case Report and Review of the Literature.

World neurosurgery
2020

A primary third ventricle mixed germ cell tumor with leptomeningeal dissemination of immature teratoma component.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2019

Glioneuronal Tumor With Features of Ganglioglioma and Neurocytoma Arising in the Fourth Ventricle: A Report of 2 Unusual Cases and a Review of Infratentorial Gangliogliomas.

Journal of neuropathology and experimental neurology
2019

Gliosarcoma in a Young Filipino Woman: A Case Report and Review of the Literature.

The American journal of case reports
2019

An epilepsy-associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation.

Pathology international
2019

Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.

Endocrine pathology
2019

Childhood cerebellar tumours mirror conserved fetal transcriptional programs.

Nature
2019

Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015.

Journal of neuro-oncology
2019

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Pediatric blood & cancer
2019

Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor.

World neurosurgery
2019

Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases.

The American journal of surgical pathology
2018

Acid-Induced Activated Cell-Penetrating Peptide-Modified Cholesterol-Conjugated Polyoxyethylene Sorbitol Oleate Mixed Micelles for pH-Triggered Drug Release and Efficient Brain Tumor Targeting Based on a Charge Reversal Mechanism.

ACS applied materials & interfaces
2019

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

Brain pathology (Zurich, Switzerland)
2019

Space-time clustering of childhood cancers: a systematic review and pooled analysis.

European journal of epidemiology
2019

Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.

Pediatric neurology
2019

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging.

Brain pathology (Zurich, Switzerland)
2018

Primary Central Nervous System Germ Cell Tumors: A Review and Update.

Medical research archives
2018

Bayesian modeling of Dynamic Contrast Enhanced MRI data in cerebral glioma patients improves the diagnostic quality of hemodynamic parameter maps.

PloS one
2018

[BRAF V600E mutation and clinicopathologic characteristics in 250 cases of brain tumors associated with epilepsy].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2018

Pediatric primary anaplastic ganglioglioma with malignant neuronal component.

The Turkish journal of pediatrics
2018

Re-induction chemotherapy regimens in patients with recurrent central nervous system mixed malignant germ cell tumors.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2018

Central Nervous System-type Neuroepithelial Tumors and Tumor-like Proliferations Developing in the Gynecologic Tract and Pelvis: Clinicopathologic Analysis of 23 Cases.

The American journal of surgical pathology
2019

Intratumoral Rathke's Cleft Cyst Remnants Within Craniopharyngioma, Pituitary Adenoma, Suprasellar Dermoid, and Epidermoid Cysts: A Ubiquitous Signature of Ectodermal Lineage or a Transitional Entity?

Neurosurgery
2018

Subependymomas - Characteristics of a "Leave me Alone" Lesion.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
2018

Schwannoma of the Fourth Ventricle: Report of Two Cases and Review of Literature.

World neurosurgery
2018

Ganglioglioma in children and young adults: single institution experience and review of the literature.

Journal of neuro-oncology
2018

A case report of targeted therapy with apatinib in a patient with recurrent high grade glioma.

Medicine
2018

[Bleomycin-induced Flagellated dermatitis: A case report].

Revista chilena de pediatria
2018

Atypical Teratoid/Rhabdoid Tumor of the Spinal Cord in a Child: Case Report and Comprehensive Review of the Literature.

Pediatric neurosurgery
2019

Tractography Verified by Intraoperative Magnetic Resonance Imaging and Subcortical Stimulation During Tumor Resection Near the Corticospinal Tract.

Operative neurosurgery (Hagerstown, Md.)
2018

Ten-eleven translocation 1 regulates methylation of autophagy-related genes in human glioma.

Neuroreport
2018

TLE1 Expression in Malignant Rhabdoid Tumor and Atypical Teratoid/Rhabdoid Tumor.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
2018

Deep learning enables reduced gadolinium dose for contrast-enhanced brain MRI.

Journal of magnetic resonance imaging : JMRI
2018

Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab.

CNS oncology
2018

Normalization of ADC does not improve correlation with overall survival in patients with high-grade glioma (HGG).

Journal of neuro-oncology
2018

Early outcomes and patterns of failure following proton therapy for nonmetastatic intracranial nongerminomatous germ cell tumors.

Pediatric blood & cancer
2018

Liponeurocytoma of the Cerebellopontine Angle.

World neurosurgery
2018

Predictors of clinical outcome in pediatric oligodendroglioma: meta-analysis of individual patient data and multiple imputation.

Journal of neurosurgery. Pediatrics
2018

Clinical features, radiologic findings, and treatment of pediatric germ cell tumors involving the basal ganglia and thalamus: a retrospective series of 15 cases at a single center.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2017

[Surgical Treatment of a Giant Olfactory Groove Schwannoma:A Case Report].

No shinkei geka. Neurological surgery
2017

Enhanced blood brain barrier permeability and glioblastoma cell targeting via thermoresponsive lipid nanoparticles.

Nanoscale
2018

Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.

Pediatric neurosurgery
2018

Fast 3D rosette spectroscopic imaging of neocortical abnormalities at 3 T: Assessment of spectral quality.

Magnetic resonance in medicine
2017

BRAF gene alterations and enhanced mammalian target of rapamycin signaling in gangliogliomas.

Neurology India
2017

Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.

Glia
2017

Subependymomas Are Low-Grade Heterogeneous Glial Neoplasms Defined by Subventricular Zone Lineage Markers.

World neurosurgery
2017

Penetration of blood-brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system.

International journal of nanomedicine
2017

Pitfalls of Neuroendoscopic Biopsy of Intraventricular Germ Cell Tumors.

World neurosurgery
2017

Species-specific real-time RT-PCR analysis of expression of stromal cell genes in a tumor xenotransplantation model in mice.

Biochemical and biophysical research communications
2017

Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New "Leave Me Alone" Lesion with a Characteristic Imaging Pattern.

AJNR. American journal of neuroradiology

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Trends in net survival for patients with brain tumors in Japan, 2000-14 (CONCORD-3).
    Japanese journal of clinical oncology· 2026· PMID 41859878mais citado
  2. Stereotactic intracranial implantation of patient-derived glioblastoma cells in rats: A xenograft modeling approach.
    Journal of neuroscience methods· 2026· PMID 41391715mais citado
  3. A functionally relevant model for interrogating brain tumor-endothelial cell interactions.
    Journal of neuroscience methods· 2026· PMID 41389895mais citado
  4. Vaccine immunotherapy for glioblastoma: How can previous attempts guide us?
    Experimental neurology· 2026· PMID 41109657mais citado
  5. The Endoscopic ExtraForaminal TransChoroid (EFTC) Approach in the Management of Pineal Tumors: Gross Total Resection through a Single Burr Hole.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery· 2026· PMID 41805728mais citado
  6. Elevation of hCG in CSF in pinealoblastoma: a pitfall rescued by pathological examination.
    Acta Neuropathol Commun· 2025· PMID 41272818recente
  7. Primary intracranial immature teratoma in an adult woman: case report and literature review.
    BMC Womens Health· 2025· PMID 40468301recente
  8. Clinical effects of neuroendoscopic infratentorial supracerebellar approach surgical technique for resecting pineal tumors: a retrospective study.
    Neurochirurgie· 2024· PMID 38908132recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:252021(Orphanet)
  2. MONDO:0016742(MONDO)
  3. GARD:20736(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q55786398(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Tumor misto das células germinativas do sistema nervoso central
Compêndio · Raras BR

Tumor misto das células germinativas do sistema nervoso central

ORPHA:252021 · MONDO:0016742
CID-10
C72.9 · Neoplasia maligna do sistema nervoso central, não especificado
CID-11
MedGen
UMLS
C1334785
Wikidata
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