Anemia falciforme

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

NCT03937817

Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

Fase II

NCT04774536

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

NCT06699849

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

NCT05170412

Functional Ovarian Reserve in Sickle Cell Disease

NCT07392216

NCT03937817 · Collection of Human Biospecimens for Basic and Clinical Rese…Recrutando

🟢 Recrutando agora

20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT04774536 · Transplantation of Clustered Regularly Interspaced Short Pal…Recrutando

PHASE1, PHASE2

NCT06699849 · Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults a…Recrutando

NCT05170412 · Dietary Intake and Dietary Behaviors in Adults With Sickle C…Recrutando

NCT07392216 · Functional Ovarian Reserve in Sickle Cell DiseaseRecrutando

NCT07247188 · Study of a Single Dose of a 21-valent Pneumococcal Conjugate…Recrutando

PHASE3

NCT06016634 · Alendronate for Osteonecrosis in Adults With Sickle Cell Dis…Recrutando

NCT07064174 · Sickle Cell Kidney BiorepositoryRecrutando

NCT06635902 · Intravenous L-Citrulline for Vaso-occlusive Pain Episode in …Recrutando

NCT06975865 · The Efficacy and Safety of Rilzabrutinib in Participants Age…Recrutando

PHASE3

NCT06880679 · Ultrasound Acute Chest Syndrome Sickle Cell DiseaseRecrutando

NA

NCT05736419 · A Study of Immune Suppression Treatment for People With Sick…Recrutando

NCT04657822 · Rollover Study for Patients With Sickle Cell Disease Who Hav…Recrutando

PHASE4

NCT05640271 · Tocilizumab for Acute Chest SyndromeRecrutando

NCT06886477 · Sickle Cell, Pain and Mediterranean DietRecrutando

NA

NCT07187973 · A Phase 1b, Open-Label Study of DISC-3405 in Participants Wi…Recrutando

PHASE1

NCT06924970 · A Dose-Finding Study of Tebapivat to Assess Efficacy, and Sa…Recrutando

NCT04416178 · Sickle Cell Disease and the Genomic and Gene Therapy Needs o…Recrutando

NCT07431398 · Single-dose Pharmacokinetics of Pociredir in Participants Wi…Recrutando

PHASE1

NCT06439082 · A Study to Investigate the Efficacy and Safety of Crizanlizu…Recrutando

PHASE3

Outros ensaios clínicos

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações

11.841 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 11.841

#1

Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells towards glycolysis.

Blood2026 Mar 24

Iron is an essential element for most cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). Abnormal iron levels impact HSC quiescence and self-renewal, however, the mechanism by which iron overload (IO) influences HSC function is still unknown. Here, we show that intracellular IO impairs mitochondrial fitness and bioenergetics, inducing metabolic rewiring. In thalassemic mice, as a model of chronic IO, HSCs accumulate mitochondria with elevated reactive oxygen species (mtROS), low membrane potential and reduced oxidative phosphorylation (OXPHOS). Mitochondrial defects are confirmed in other two models of IO, sickle cell disease and iron-loaded wild-type mice, and in vivo iron reduction rescues HSC mitochondria. IO HSCs are highly proliferating and in presence of damaged mitochondria rely on glycolysis for energy production. Notably, restoration of mitochondrial function by targeting in vivo mtROS improved the quiescence and self-renewal of IO HSCs. Our results unravel the critical interplay between iron, ROS and mitochondrial activity in HSCs, revealing that IO shapes HSC metabolic programs.

#2

Cystic Fibrosis and Sickle Cell Disease Associated with Non-administration of VTE Prophylaxis in Hospitalized Adults.

Blood advances2026 Mar 24

Cystic fibrosis (CF) and sickle cell disease (SCD) are associated with increased risk of venous thromboembolism (VTE), and this risk is exacerbated by hospitalization. VTE prophylaxis non-administration is a VTE risk factor. The objective of this study was to characterize VTE prophylaxis non-administration among patients with either CF or SCD compared to medically ill patients without CF or SCD. We conducted a single-center retrospective cohort study of hospitalized patients who were prescribed at least 2 doses of pharmacologic VTE prophylaxis. The primary outcome was the proportion of non-administered VTE prophylaxis doses by cohort. Multivariable logistic regression was used to identify characteristics associated with non-administration. A total of 13,316 patients were included; 89 with CF, 246 with SCD, and 12,981 other-medically ill. During the study period, 95,697 doses were prescribed; non-administration rates were 61.8% in the CF cohort, 32.7% in the SCD cohort, and 19.7% in the medically ill cohort (p<0.01). In the multivariable logistic regression, CF or SCD diagnosis [odds ratio (OR) 2.03, 95% confidence interval (CI) 1.59-2.6], multiple admissions (OR 2.4, 95% CI 2.19-2.64), and >5 prescribed doses of VTE prophylaxis (OR 2.48, 95% CI 2.29-2.69) were associated with non-administration of one or more doses. The percent of missed doses (median, IQR) per patient was highest in the CF cohort (66.7%, 84.5), followed by the SCD cohort (10.6%, 50), and medically ill cohort (0%, 16.7, p<0.01). These findings suggest strategies to improve VTE prophylaxis administration rates during acute hospitalization in high-risk conditions such as CF and SCD are needed.

#3

Technology Access and Preferences for Smartphone App Interventions to Optimize Iron Chelation Therapy Adherence Among Adolescents, Young Adults, and Parents of Children Receiving Chronic Transfusions: Cross-Sectional Survey Study.

JMIR pediatrics and parenting2026 Mar 24

Iron chelation therapy (ICT) is essential for people with hematological disorders requiring chronic transfusions to minimize the risk of iron overload, yet suboptimal adherence is prevalent. Widespread use of personal technology makes mobile health (mHealth) an attractive platform to promote adherence. This study aimed to examine access to mobile technology and preferences for an mHealth intervention to improve adherence to ICT. A cross-sectional survey that included 63 items assessing technology access, mHealth preferences, and demographics was administered through REDCap (Research Electronic Data Capture), a digital research data tool, during packed red blood cell transfusion visits. Parents of children receiving chronic transfusions, as well as adolescents and young adults receiving chronic transfusions, were enrolled between August 2018 and June 2019. Patients had to have a hematologic diagnosis requiring chronic transfusions, be receiving ICT, and be aged 12 years or older to complete the survey. Parents were required to have a child aged 24 months who met these criteria. A total of 60 participants were included (median age 31.5, IQR 20-39 years; n=40, 67% female), with 29 (48%) being parents and 31 (52%) being patients. All parents and patients owned an electronic tablet, a smartphone, or both. The most endorsed mHealth app features among all participants included laboratory test monitoring (55/60, 92%), reminders to take iron chelation medication (50/60, 83%), and education about ICT (49/60, 82%). Parents' most endorsed features included laboratory test monitoring (27/29, 93%) and education about ICT (25/29, 86%). Patients' most endorsed features included laboratory test monitoring (28/31, 90%) and reminders to take iron chelation medication (28/31, 90%). There were no substantial differences between parents and patients in their preferences. Both parents and adolescents and young adults reported a strong interest in multiple mHealth app features. Participants provided valuable insights into optimal strategies and preferred app features for developing a multifunctional technology-based behavioral intervention to promote ICT adherence.

#4

Nonmyeloablative pentostatin-cyclophosphamide preconditioning improves rates of engraftment in adults undergoing haploidentical HCT for sickle cell disease.

PloS one2026

The morbidity and mortality of sickle cell disease (SCD) remain high. Novel nonmyeloablative haploidentical hematopoietic cell transplant (HCT) regimens are being proposed. This report compared the effect of adding an IV pentostatin and oral cyclophosphamide (PC) preconditioning to the nonmyeloablative NIH HCT platform of alemtuzumab and total body irradiation (TBI) in adults with severe SCD. Transplant outcomes were compared to a historical HCT cohort that did not receive the PC preconditioning. Thirty-nine adult SCD patients were included. The median age was 33 years, 61% were male, and 92% were HbSS genotype. The median follow-up was 6.5 years. Many patients had severe end-organ damage, including dialysis-dependent end-stage kidney disease (8%) and cirrhosis (10%). One-year overall survival was 95%. The PC regimen was associated with a reduction in acute rejection one-year post-HCT (5% vs. 44%; p = 0.004) and lower graft failure rates throughout the follow-up period. After a median follow-up of 5.2 years, the disease-free survival was 71% for the PC regimen. The PC preconditioning was associated with higher rates of full donor chimerism at 2-years post-HCT (0% vs. 43%; p = 0.02). Grade II-IV acute graft-versus-host disease (GVHD) rates were low; no patients developed moderate to severe chronic GVHD. There remain no cases of myeloid malignancy after PC. With the increased immunosuppression of PC, 23% of patients developed post-transplant lymphoproliferative disorder, 19% developed immune cytopenias, and 62% had viral reactivation. Further study to determine an optimal nonmyeloablative haploidentical regimen for SCD patients with compromised organ function is imperative. ClinicalTrials.gov (NCT00977691, NCT03077542).

#5

Novel use of a Hash-Based Tokenization for Sharing Sickle Cell Disease Data Without Sharing PHI.

Blood advances2026 Mar 20

Efforts to improve care for people living with sickle cell disease (SCD) have led to the development of several registries; however, many are dependent on time-limited funding and lack coordination. Consequently, existing datasets are fragmented and do not provide the comprehensive, longitudinal insights achievable through well-integrated registries. Although relevant data exist within electronic medical records across institutions, aggregation is limited by poor interoperability, inconsistent use of common data elements, and poor translation of natural language into codified data. These barriers hinder population-level research and contribute to gaps in understanding the lifelong progression of SCD. Creating a new common data system risk losing years of valuable data, highlighting the need to optimize existing data resources. This study aimed to develop a privacy-preserving method to securely link three of the largest SCD data collection efforts in the United States. Conducted at the University of Alabama at Birmingham Lifespan Sickle Cell Center, the study leveraged IRB-approved access to the Sickle Cell Data Collection project, the American Society of Hematology Research Collaborative Data Hub, and the Globin Research Network for Data and Discovery (GRNDaD). Identity tokens were generated and hashed using SHA-256 to enable secure linkage without sharing protected health information. 8,026 records were identified across the three registries. Deterministic matching of hashed tokens identified 1,080 unique individuals appearing in at least two datasets. This study demonstrates the first privacy-preserving linkage of multiple SCD registries. Secure data integration enhances interoperability and enables richer longitudinal analyses critical for advancing SCD research and treatment development.

Publicações recentes

Periprosthetic Joint Infection With Salmonella Species 2 Years After Unicompartmental Knee Arthroplasty Treated With Debridement, Antibiotics, and Implant Retention (DAIR): A Case Report and Review of the Literature.

Case Rep Orthop2026

Management of hematogenous osteomyelitis in children in Douala, Cameroon: diagnostic challenges, complications, and perspectives for improvement.

Front Pediatr2026

Decoupling Detection and Classification to Improve Morphological Phenotype Analysis of Sickle Red Blood Cells in Full-Scope Microscopy.

bioRxiv2026 Apr 6

Advancing Pain Care for Individuals with Sickle Cell Disease: Two Innovative Psychological Approaches.

J Clin Psychol Med Settings2026 Apr 16

A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients.

Br J Haematol2026 Apr 16

Ver todas no PubMed

📚 EuropePMC14.972 artigos no totalmostrando 198

Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells towards glycolysis.

Blood

Cystic Fibrosis and Sickle Cell Disease Associated with Non-administration of VTE Prophylaxis in Hospitalized Adults.

JMIR pediatrics and parenting

Technology Access and Preferences for Smartphone App Interventions to Optimize Iron Chelation Therapy Adherence Among Adolescents, Young Adults, and Parents of Children Receiving Chronic Transfusions: Cross-Sectional Survey Study.

Fulminant Acute Chest Syndrome and Multiorgan Failure in Sickle Cell Disease With Chronic Hepatic Vasculopathy: A Fatal Synergy.

Outcomes of hematopoietic stem cell transplantation in adult sickle cell disease patients: A Single-Center experience from India.

Archives of biochemistry and biophysics

Myeloperoxidase in the pathogenesis of sickle cell disease.

Function (Oxford, England)

ENDOTHELIUM-DERIVED ENDOTHELIN-1 MEDIATES SICKLE CELL NEPHROPATHY.

Nonmyeloablative pentostatin-cyclophosphamide preconditioning improves rates of engraftment in adults undergoing haploidentical HCT for sickle cell disease.

PloS one

Journal of clinical psychology in medical settings

Patient Experiences of Acute Pain Communication in Sickle Cell Disease and Perspectives on Improving Clinician Communication.

The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia-Associated Kidney Function.

Recruitment and retention of young adults with sickle cell disease.

Health care transitions

Expert opinion on emerging drugs

Exploring the latest emerging drugs for the treatment of sickle cell disease.

Association of PON1 gene polymorphisms, paraoxonase 1 gene expression and activity in Egyptian children and adolescents with sickle cell disease.

BMC pediatrics

International journal of laboratory hematology

Cryopreservation of Red Blood Cells From Sickle Cell Disease Patients for Comparison of Oxygen Gradient Ektacytometry Parameters Between Laboratories to Enable Data Harmonization.

Novel use of a Hash-Based Tokenization for Sharing Sickle Cell Disease Data Without Sharing PHI.

Biophysical characterization of spCas9 binding and cleavage using real-time electronic biosensors.

Sensors & diagnostics

European journal of haematology

Prevention and Management of Acute Chest Syndrome Without Automated Red Cell Exchange Among Patients With Sickle Cell Disease Not Requiring ICU Care: A Systematic Review and Network Meta-Analysis.

Elevated tricuspid regurgitation velocity in adults with sickle cell disease and HbAA controls in Kinshasa, Democratic Republic of the Congo: a comparative cross-sectional study.

Bone marrow transplantation

Can pre-transplant sickle cell disease characteristics predict early post-transplant complications?

Action taken upon the detection of sickle cell trait (heterozygous hemoglobinopathy S) in newborn screening in Spain.

Revista clinica espanola

Plasma proteome signatures are predictive of mortality in sickle cell disease.

IFN-I-Mediated Transcriptional Reprogramming Drives Myeloid-Skewed Hematopoiesis in Sickle Cell Anemia.

Fat Embolization Syndrome in Sickle Cell Disease: A Case Report.

Variations in mitochondrial genome as potential prognostic markers in sickle cell disease.

Predictors of Acute Chest Syndrome in Patients With Sickle Cell Disease: A Cross-Sectional Observational Study.

Welding the Gap on Sickle Cell Education.

Characterizing Engagement With a Mobile Health Application Designed for Adolescents and Young Adults With Sickle Cell Disease: Findings From the COMETS Study.

Bone marrow transplantation

Imaging biomarkers to predict the development of sinusoidal obstruction syndrome of the liver in pediatric hematopoietic cell transplant recipients.

The Pan African medical journal

Stroke risk assessment in children with sickle cell disease using transcranial Doppler ultrasound in Cameroon.

Staged Total Hip Arthroplasty for Septic Hip Following Core Decompression in Sickle Cell-Related Osteonecrosis: A Case Report and Review of the Literature.

Journal of public health research

A mixed-methods evaluation to optimize the existing hospital based sickle cell disease care model from a tribal area of Gujarat, India.

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O-Arab and Alpha-Thalassemia.

Longitudinal Trends of Pica Behaviors, Behavioral Support, and Healthcare Utilization in Pediatric Sickle Cell Disease.

Reproductive Health and Pregnancy Outcomes Among Women With Sickle Cell Disease in Tribal Communities of India: A Community-Based Retrospective Comparative Study.

Pyruvate kinase activators in hereditary haemolytic anaemias: current evidence and clinical potential.

Lancet (London, England)

Back to basics in sickle cell disease.

Lancet (London, England)

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview.

Genetics and Genomics in Sickle Cell Disease in Africa.

Sickle Cell Disease in Sub-Saharan Africa: Progress and Potential.

The Epidemiology of Sickle Cell Disease in Sub-Saharan Africa: Current Knowledge and Gaps to be Filled.

Advancing Sickle Cell Disease Treatment in Sub-Saharan Africa: Challenges and Opportunities for Disease Modifying Therapies.

Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub-Saharan Africa.

BMC health services research

Mechanism-informed transition from pediatric to adult care in sickle cell disease: a case study.

Journal of neurosurgery. Pediatrics

Understanding stroke risk phenotypes in pediatric patients with sickle cell disease and concurrent moyamoya arteriopathy: insights from 61 cases at a single institution.

Unheard and Under-Supported: Health-Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease.

bioRxiv : the preprint server for biology

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells.

Journal of vitreoretinal diseases

Loss to Follow-Up Rates Among Pediatric Sickle Cell Disease Patients in an Ophthalmology Clinic.

Benefits of isovolemic hemodilution red cell exchange: Real or imagined?

Transfusion

TheScientificWorldJournal

Oxidative Stress, Antioxidant Capacity, Dyslipidemia and Cardiovascular Risk in Sickle Cell Disease: A Systematic Review and Meta-Analysis.

Hip Osteonecrosis in Sickle Cell Disease Patient With Severe Central Head Collapse Treated With Staged Hip Preservation: A Case Report.

JBJS case connector

Low self-esteem in adolescents with sickle cell disease: Determinants and coping mechanisms; A mixed methods study.

PloS one

Burnout in Sickle Cell Disease-Focused Hematology-Oncology Trained Physicians: A National Cross-Sectional Study.

Journal of orthopaedic case reports

Total Hip Arthroplasty in Lubumbashi (DR Congo), Outcomes in a Resource-Limited Setting.

Adolescent Cholelithiasis: Evolving Challenges and Clinical Implications.

The American journal of emergency medicine

Use of standardized order sets and associated outcomes in the Emergency Department: A scoping review.

Artificial intelligence in medicine

A multi-feature alignment fusion neural network model for red blood cell aggregation classification using ultrasonic radiofrequency data of blood.

Newborn Screening Results for Sickle Cell Disease from the ASH Consortium on Newborn Screening in Africa (CONSA).

Sodium glucose co-transporter inhibition as a strategy to stabilize the microvasculature in sickle cell disease.

Cardiovascular research

Molecular imaging and biology

Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease.

CRISPR in Medicine: A Systematic Review of Clinical Trials and Therapeutic Applications.

Human gene therapy

Research and practice in thrombosis and haemostasis

Management of venous thrombosis in sickle cell disease: a comparative study on the use of direct oral anticoagulants and warfarin.

Long-term mitapivat treatment is safe and efficacious in patients with sickle cell disease.

Blood. Red cells & iron

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

The Impact of Aging on Organ Systems in Sickle Cell Disease: a Comparative Review of Physiological Adaptation and Dysfunction.

MULTIsite feasibility of MUSIc therapy to address Quality Of Life in Sickle cell disease (MULTI-MUSIQOLS): protocol for a mixed-methods randomised controlled trial at two US medical centres.

BMJ open

Asthma screening in children with sickle cell disease in French Guiana.

BMJ paediatrics open

Journal of ethnopharmacology

Beyond HbS polymerization inhibition: Antioxidant and anti-hemolytic actions of two varieties of Vigna sesquipedalis (L.) F.Agcaoili in sickle cell disease.

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension.

HemaSphere

Global Burden of Sickle Cell Disease: Adequacy of Pain Control as Evidenced by Frequency of Oral Pain Medication Use, Health Outcomes, and Emotional Well-Being Across Diverse Populations.

EJHaem

Frontiers in cardiovascular medicine

Sickle cell related cardiomyopathy and cardiovascular autonomic dysfunction.

Pediatric Hepatobiliary Lithiasis in Homozygous Sickle Cell Disease: Laboratory Insights Into Cholestasis and Hemolysis.

Clinical medicine insights. Pediatrics

Hydroxyurea in Sickle Cell Disease: Coagulation and Activation in an Observational Study.

Gene expression profiling identifies potential biomarkers for vaso-occlusive episodes in sickle cell disease.

JCI insight

Loss of energy homeostasis contributes to hepatic damage development in sickle cell disease.

Molecular metabolism

Liver Cirrhosis and In-Hospital Outcomes in Patients With Sickle Cell Crises.

EJHaem

Pain medicine case reports

Peripheral Nerve Stimulation for Intractable Neuropathic Foot Pain in Sickle Cell Disease: A Case Report Introducing a Novel Interventional Approach.

Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices.

Journal of community genetics

Role of the primary healthcare providers in sickle cell disease management: a scoping review.

A maximal-coverage approach to prioritizing newborn sickle cell screening sites in Uganda using a sickle cell-malaria co-risk surface.

Malaria journal

FAIR data gaps and collaboration willingness among hemoglobinopathy research centers.

Scientific data

The Journal of infectious diseases

Nasopharyngeal Microbiome Composition and its Clinical Correlates in Children Hospitalized with Severe Pneumonia in East Africa.

Journal of blood medicine

Current Status of Clinical Gene Therapy for Hemophilia and Globin Disorders.

Neurological Complications in Sickle Cell Disease: Clinical, Analytical and Radiological Correlations in a Multicentre Cohort.

Hemoglobin

Journal of health, population, and nutrition

Genetic blood disorder status awareness and factors influencing willingness or reluctance to undergo premarital screening among young adults in Ahafo Region, Ghana: a cross-sectional survey.

Journal of infusion nursing : the official publication of the Infusion Nurses Society

Upper Limb Edema as Predictor of Difficult Peripheral Intravenous Cannulation.

Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling.

Science advances

Clinical journal of the American Society of Nephrology : CJASN

Alterations of Plasma Metabolites Associated with Sickle Cell Trait.

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.

Diagnosis and Management of Acute Chest Syndrome in Children With Sickle Cell Disease.

Pharmaceuticals (Basel, Switzerland)

Physiologically Based Pharmacokinetic Modelling of Hydroxyurea in Patients with Sickle Cell Disease: A Special Focus on Lactating Women and Breastfed Infants to Inform Safe Dosing and Breastfeeding Strategies.

Genomic Characterization of Salmonella Isolates Causing Infections in Children with Sickle Cell Disease in Dakar, Senegal.

Microorganisms

Journal of clinical medicine

Curative Approach to the Treatment of Beta-Thalassemia and Sickle Cell Disease with Hematopoietic Stem Cell Transplantation.

Journal of clinical medicine

Systematic Review of Non-Coding Genomic Variants in Globin and Non-Globin Clusters and Their Impact on Phenotypic Severity in Thalassemia and Sickle Cell Disease.

Life (Basel, Switzerland)

Sickle Cell Disease and Male Infertility: Pathophysiological Mechanisms, Clinical Manifestations, and Fertility Preservation Strategies-A Narrative Review.

Medicina (Kaunas, Lithuania)

Prevalence and Predictors of Priapism Among Patients with Sickle Cell Disease: A Cross-Sectional Study.

Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymorphisms Identified by GWAS, and Advances in γ-Globin Editing: An Updated Overview.

Genes

Medically Unnecessary Venipuncture in Autism Spectrum Disorder Behavior Assessments.

Pediatric emergency care

Cost-effectiveness of gene therapy for sickle cell disease in Uganda: tailoring high-income evidence to Uganda's context.

Gene therapy

Blood cells, molecules & diseases

Inflammatory markers in sickle cell disease during vaso-occlusive crisis.

Diagnostic accuracy of the sickle SCAN® rapid test for neonatal screening of sickle cell disease in Lubumbashi, Democratic Republic of the Congo.

Minutes Matter: An Audit of the Timeliness of Opioid Administration for Sickle Cell Disease Pain in the Emergency Department and Association With Disposition.

Rethinking Sickle Cell Disease as a Systemic Vasculopathy.

Cells

Pregnancy-Triggered Vaso-Occlusive Crises in Hemoglobin SE Disease Complicated by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report.

Three-year safety, efficacy, and renal outcomes of mitapivat treatment in sickle cell disease: results from the phase 2 open-label study.

Haploidentical transplantation in sickle cell disease: toward donor availability for all patients.

Pyruvate Kinase Activators for Sickle Cell Disease: An Exploratory Systematic Review and Meta-Analysis.

Hemoglobin

Clinics in laboratory medicine

Emerging Considerations in Transfusion Medicine: Hematopoietic Stem and Progenitor Cell Collection for Gene Therapy for Sickle Cell Disease and Transfusion-Dependent Thalassemia.

Clinics in laboratory medicine

Expanding the Blood Donor Pool: An Update to Initiatives to Increase New Donor Participation.

Feasibility and Characteristics of Systematic Transcranial Doppler in Adults With Sickle Cell Disease: A Cross-Sectional Single Center Study.

Journal of blood medicine

Haematological Profile of Patients with Sickle Cell Disease in the Acholi Sub-Region, Uganda.

Urinary carbonic anhydrase 1 excretion is a marker of hemolysis-triggering conditions suitable for point-of-care testing.

Blood global hematology

Molecular therapy. Nucleic acids

Complex HBB gene editing outcomes revealed by a fluorescent reporter cell model.

Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis.

Angiology

Journal of clinical apheresis

Cerebral Fat Embolism Syndrome in Homozygous Sickle Cell Disease Treated With Therapeutic Plasma Exchange and Simple Transfusions.

CPT: pharmacometrics & systems pharmacology

Assessment and Benchmarking of Model Informed Approaches in Drug Development for Hemoglobinopathies: A Review of Scientific Advices From January 2000 to December 2024.

Annals of biomedical engineering

Radiomic Features Extracted from Magnetic Resonance Imaging to Identify Arteriopathy in a Humanized Mouse Model of Sickle Cell Anemia and Sickle Cell Trait.

Evaluation of the Neuropathic Component of Pain in Sickle Cell Disease.

Hemoglobin

Annals of internal medicine

Addressing Primary Care Needs in People Living With Sickle Cell Disease : A Narrative Review.

Journal of medical economics

Cost-effectiveness of exagamglogene autotemcel gene-edited therapy in patients with sickle cell disease with recurrent vaso-occlusive crises in the United States.

Does self-compassion moderate the relationship between stigma, pain and psychological well-being among people living with sickle cell disease in Ghana?

PLOS mental health

Journal of the American College of Radiology : JACR

ACR Appropriateness Criteria® Chest Pain-Child.

Temporal trends and determinants of ED visits in sickle cell disease: a multicenter EHR study from Saudi Arabia (2016-2021).

Frontiers in medicine

Non-aneurysmal Subarachnoid Hemorrhage in an Adult With Sickle Cell Anemia: A Case Report and Review of the Literature.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Impact of HBS1L-MYB Gene Single Nucleotide Polymorphisms on Fetal Hemoglobin Expression in Moroccan Sickle Cell Anemia Children: Preliminary Results.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Unveiling Bone Health in Sickle Cell Disease: A Comprehensive Analysis of Bone Mineral Density.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Reproductive Health in Women with Sickle Cell Disease: A Cross-Sectional Study from Endemic Tribal Regions of India.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Evaluation of Diagnostic Accuracy of Sickle SCAN™, and Gazelle™ for Screening Hemoglobin S in india.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Cross-Cultural Adaptation, Reliability and Validity of MOS Short Form Health Survey (SF-36) in Sickle Cell Disease Patients in India.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Gene Therapy for Sickle Cell Anemia in India - Current Status and Challenges.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Path To Sickle Cell Disease Elimination in India: from Precision Diagnostics and Comprehensive Care To Curative Horizons.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Sickle Cell Disease in Central India: Haematological and Clinical Insights from a Large Cohort of Patients.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Synergistic Potential of Thalidomide and Hydroxyurea in Sickle Cell Disease Management: A Promising Combination Therapy.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Indian College of Hematology (ICH)& Indian Council of Medical Research (ICMR) Joint Consensus Document on Management and Control of Sickle Cell Disease in India.

Artificial Intelligence Applications in Sickle Cell Retinopathy Imaging: Current Progress, Challenges, and Future Directions.

Journal of ophthalmology

Quantifications of CD4+ T-Lymphocytes levels in adult sickle cell patients: Examining immunological vulnerability and Vaso-Occlusive crises in a low-resource setting, northwestern Nigeria.

Oxford open immunology

Expert review of hematology

Prevalence of mental health conditions among individuals with sickle cell disease in Texas Medicaid.

Blood cells, molecules & diseases

Newborn screening for sickle cell disease in Angola: Implementation challenges and emerging data on hemoglobinopathy prevalence.

Blood cells, molecules & diseases

Exercise training adaptations on cardiorespiratory fitness and quality of life of patients with sickle cell disease: A systematic review.

Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts.

Stem cell research

Database : the journal of biological databases and curation

The Sickle Africa Data Coordinating Centre (SADaCC): a data science hub for interdisciplinary sickle cell disease research and training.

Sickle Cell Vaso-Occlusive Episodes Correlates with the Magnetic Heterogeneity of Red Blood Cell.

International journal of neonatal screening

Newborn Screening for Hemoglobinopathies and Thalassemias: Brief History, Recent Activities, and Global Status-2026.

International journal of neonatal screening

Integrated Newborn Screening in Nigeria: The Way Forward, A Workshop Report.

International journal of neonatal screening

Advances and Gaps in Global Newborn Screening for Sickle Cell Disease.

Traumatic Spinal Cord Infarction Associated With Elevated Intracranial and Intraspinal Pressure in a Pediatric Patient: A Case Report and Review of the Literature.

Transition Readiness Assessment Questionnaire: A Tool Associated With Transfer Success for Adolescents and Young Adults Living With Sickle Cell Disease?

EJHaem

British journal of haematology

Circulating angiogenesis-related biomarkers in sickle cell retinopathy and maculopathy.

Orphanet journal of rare diseases

Narratives unveil knowledge and awareness-related issue, reinforcing patients' self-identity in sickle cell disease.

The Lancet. Global health

Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial.

Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in brazil: retrospective cohort study of real-world data.

Saudi journal of anaesthesia

Novel use of genicular and vastus intermedius blocks for refractory knee pain in sickle cell disease.

The American journal of nursing

New consensus statement issued for sickle cell disease.

Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study.

BMC medicine

G-CSF for Mobilizing CD34+ Cells in Individuals With SCD: A Word of Caution.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Comparison of Mortality and Complications After Total Hip Arthroplasty in Patients with Sickle Cell Disease: A Retrospective Match-Controlled Study from Türkiye.

Exploring the temporal relationship between psychosocial risk factors and recurrent ischemic priapism.

Sexual medicine

The American journal of tropical medicine and hygiene

Interventions to Prevent Post-Discharge Mortality among Children in Sub-Saharan Africa: A Systematic Review.

Safety and effectiveness of voxelotor in individuals with sickle cell disease in the RETRO and PROSPECT US registries.

Adding to the Sickle Cell Disease Burden: Rising Hydroxyurea Costs Demand Action.

Expert review of hematology

The emerging role of complement inhibitory approaches in the treatment of acute sickle cell disease complications.

Expert review of hematology

Improving endpoints for sickle cell disease clinical trials: retaining consistency and clinical benefit.

Gut microbiome profile among children and adolescents living with sickle cell disease: a protocol for systematic review and meta-analysis.

BMJ open

Blood vessels, thrombosis & hemostasis

A novel palmitoylethanolamide formulation improves hyperalgesia and red cell instability in murine sickle cell disease.

Case reports in ophthalmology

Sickle Cell Crisis-Induced Painless Bilateral Orbital Bone Infarction: A Case Report.

A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease.

JPGN reports

Diagnostic Limitations of Hemoglobin A1c in the Setting of Compound Hemoglobinopathy: A Case Report of Sickle Cell Disease, Alpha Thalassemia, and Occult Diabetes.

Priapism as an Initial Presentation of Sickle Cell Disease: A Case Report.

Biomedical optics express

Correlation between diffuse correlation spectroscopy and transcranial Doppler ultrasound in pediatric sickle cell disease.

Laboratory and genetic characteristic associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study.

Transplantation and cellular therapy

Long-term Follow-up After Mixed Donor Myeloid Chimerism at 1 Year Post Transplantation for Sickle Cell Disease.

Strategies and innovations in hypertension management for sickle cell patients: A narrative review.

Medicine

One cell at a time: HbF distribution in sickle cell disease.

International journal of molecular sciences

miRNA-Mediated Regulation of γ-Globin to β-Globin Switching: Therapeutic Potential in β-Hemoglobinopathies.

Molecules (Basel, Switzerland)

Red Blood Cells in Normal and Pathological States: Redox Reactions of Hemoglobin.

Journal of clinical medicine

Gynecologic and Reproductive Health in Patients with Sickle Cell Disease: Underrecognized Challenges and Care Management Opportunities.

Diagnostics (Basel, Switzerland)

Toward AI-Assisted Sickle Cell Screening: A Controlled Comparison of CNN, Transformer, and Hybrid Architectures Using Public Blood-Smear Images.

Journal francais d'ophtalmologie

Screening for sickle cell retinopathy: A comparison of systematic angiography and ultra-widefield imaging.

Heart starts suffering early in sickle cell disease.

Annals of medicine and surgery (2012)

Behçet's disease and avascular necrosis of the knees: a case report.

Annals of medicine and surgery (2012)

From policy to practice: World Health Organization's contribution to safer blood transfusions in Africa for sickle cell management - a review.

Heterozygous ABCC6 mutation in a patient with sickle cell disease: Pseudoxanthoma elasticum or pseudoxanthoma elasticum-like phenotype?

JAAD case reports

Burden and outcomes of cardiovascular and pulmonary complications in adolescents and adults with sickle cell disease: a systematic review and meta-analysis.

Systematic reviews

The Incidences of S and s Antigens of the MNS Blood Group System in the Western Region of Saudi Arabia.

Clinical laboratory

British journal of haematology

Stroke burden and functional impacts in adults with sickle cell disease.

Disseminated melioidosis complicated by osteomyelitis and pulmonary embolism in a patient with sickle cell disease and type 1 diabetes: A rare clinical triad.

Tropical doctor

Abdominal radiology (New York)

Multimodal imaging features to diagnose abdominal complications of sickle cell disease.

Disability and rehabilitation

Effect of fully immersive virtual reality on daily pain, functional mobility, and health-related quality of life in pediatric sickle cell disease: a single-blinded randomized clinical trial.

The American journal of tropical medicine and hygiene

Chronic Pediatric Diseases in Remote Villages of French Guiana Over a 9-Year Period.

A call to integrate mental health support into Sickle Cell Disease care: The value of task-sharing in low- and middle-income countries.

PLOS mental health

Exploring the quality of life of caregivers of children with sickle cell disease in a secondary health facility in Ghana.

Ghana medical journal

A Qualitative Study of the Lived Experiences of Pregnancy and Childbirth: Unheard Voices of Black Women With Sickle Cell Disease.

SAGE open nursing

Indian journal of medical microbiology

Melioidosis in sickle cell hemoglobinopathies in eastern India: Cavitating pneumonia and immune susceptibility - a case series-based insight.

Platelet-neutrophil ratio as a potential biomarker for stroke risk stratification in children and young adults with sickle cell anaemia in resource poor settings.

Epidemiological and comorbidity burden in transfusion-dependent patients with thalassemia and sickle cell disease in Greece.

African journal of laboratory medicine

The β-goblin gene architecture in individuals with and without sickle cell disease in Nigeria: Implications for β-thalassaemia trait diagnosis.

Innovations in clinical neuroscience

Validation of a Pediatric Cognitive Assessment Tool to Advance Knowledge on Children's Cognitive Development, Health Risk Factors, and Health-promoting Interventions in Sub-Saharan Regions.

Effectiveness of psychological interventions for children eligible for pediatric palliative care: systematic review and meta-analysis.

BMC pediatrics

Biochemical and biophysical research communications

NLRP3 inflammasome-mediated platelet hyperreactivity in sickle cell mice is targetable by BTK inhibition.