Ceratite fúngica

Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A

NCT06658002

RECRUTANDO

Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis

NCT06463678

EM ANDAMENTO

Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction

NCT05110001

CONCLUÍDO

Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers

NCT02731638

CONCLUÍDO

The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study

NCT05655689

CONCLUÍDO

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NCT06463678 · Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In t…Em breve

Outros ensaios clínicos

18 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase

PHASE2

NCT05110001 · Rose Bengal Electromagnetic Activation With Green Light for …Concluído

NCT02731638 · Mycotic Antimicrobial Localized Injection for Treatment of C…Concluído

NCT05655689 · The Antibiogram and Outcomes of Antimicrobial Regimens in Mi…Concluído

NCT05620264 · Validation of Interleukins and Other Cytokines Together With…UNKNOWN

NCT06070883 · Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantat…Concluído

NA

NCT00557362 · Therapeutic Exploratory Study of Comparing Natamycin and Vor…Concluído

PHASE1, PHASE2

NCT02088970 · Safety and Efficacity of Corneal Collagen Crosslinking in In…Encerrado

NA

NCT01831206 · Collagen Cross-linking in Infectious Keratitis TrialConcluído

PHASE2

NCT00516399 · A Clinical Trial of the Treatment of Fungal Corneal Ulcers W…Encerrado

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

1.406 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.406

#1

Diagnostic Accuracy of a CRISPR-Based Assay in Smear- and Culture-Negative Fungal Keratitis.

JAMA ophthalmology2026 Mar 05

Diagnosing fungal keratitis (FK) in patients with negative smear and culture results remains clinically challenging, highlighting the need for alternative diagnostic approaches. To determine the diagnostic accuracy of the clustered regularly interspaced short palindromic repeats (CRISPR)-based Rapid Identification of Mycoses using CRISPR (RID-MyC) assay for detecting FK in patients with negative smear and culture results using in vivo confocal microscopy (IVCM) as the reference standard. This prospective diagnostic accuracy study was conducted from December 2024 to March 2025 at Aravind Eye Hospital, a tertiary ophthalmology referral hospital in Coimbatore, India. Consecutive patients clinically suspected to have microbial keratitis with negative smear and culture results were eligible for inclusion. Data were analyzed from March 2025 to June 2025. All included participants underwent corneal scraping for RID-MyC assay and imaging by IVCM. The primary outcomes were sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic concordance of the RID-MyC assay compared with IVCM results. Of 245 consecutive patients clinically suspected to have microbial keratitis, 82 were smear negative. After exclusions due to contraindications or positive subsequent cultures, 41 patients with smear- and culture-negative results were ultimately included in the final analysis. Of these 41 patients (mean [SD] age, 51.0 [14.6] years; 21 [51.2%] women), RID-MyC demonstrated sensitivity of 82.1% (95% CI, 63%-94%) and specificity of 76.9% (95% CI, 46%-95%). Positive predictive value was 88.5% (95% CI, 74%-95%) and negative predictive value was 66.7% (95% CI, 46%-82%). Concordance between RID-MyC and IVCM was observed in 33 cases (80.5%). Notably, prior antifungal treatment was most frequent (4 of 5 [80%]) among patients with positive IVCM but negative RID-MyC results. Conversely, all patients (3 of 3 [100%]) with negative IVCM but positive RID-MyC findings had smaller, peripheral, or paracentral lesions. In this diagnostic study, in patients with smear- and culture-negative FK, the RID-MyC assay showed good diagnostic accuracy comparable with IVCM and was feasible in all cases, including those in whom imaging was not possible. With its rapid turnaround and minimal equipment needs, RID-MyC may serve as a practical adjunct to conventional diagnostics, particularly in high-burden, resource-limited settings where IVCM is unavailable or contraindicated.

#2

Detection of Endothelial Plaque in Microbial Keratitis Using Anterior Segment Optical Coherence Tomography.

medRxiv : the preprint server for health sciences2026 Feb 04

To evaluate the intra- and inter-grader concordance of anterior segment optical coherence tomography (ASOCT) grading for detection of endothelial plaque in microbial keratitis, and to compare endothelial plaque detection via ASOCT grading versus in-person slit lamp examination. Diagnostic concordance study of 150 consecutive patients with microbiologically confirmed bacterial or fungal keratitis at a high-volume tertiary eye hospital in India. Two masked ophthalmologist graders independently evaluated ASOCT images for presence of two morphologically distinct endothelial plaque subtypes noted during image review (round and flat plaques). We assessed intra-grader and inter-grader concordance for each endothelial plaque morphology and for presence of either morphology. Diagnostic agreement between ASOCT and in-person slit lamp examination was evaluated using percent agreement, Cohen's kappa, sensitivity, and specificity. Univariable and multivariable logistic regression was used to assess odds of disagreement between ASOCT and slit lamp examination for endothelial plaque detection. ASOCT detection showed near perfect inter-grader agreement for round endothelial plaques (kappa 0.88, 94.7% agreement), flat endothelial plaques (kappa 0.84, 92.0% agreement), and either plaque (kappa 0.88, 94.0% agreement). Intra-grader agreement was substantial to near perfect for both graders across all plaque types (kappa 0.70-0.86). Ophthalmologist slit lamp examination identified endothelial plaque in 6.0% eyes, while ASOCT detected round plaques in 32.7%, flat plaques in 43.3%, and either plaque in 55.3% of eyes. Using ASOCT as reference, slit lamp examination demonstrated sensitivity of 16.3% for round plaques, 6.2% for flat plaques, and 9.6% for either plaque, with specificity exceeding 94% for all. Poor visual acuity (logMAR ≥1.0) was associated with increased disagreement for round plaques (adjusted OR 5.04), flat plaques (adjusted OR 3.63), and either plaque (adjusted OR 3.98). Bacterial infection was associated with increased disagreement for any endothelial plaque (adjusted OR 4.56). Slit lamp examination substantially under-detects endothelial plaque compared to ASOCT, while ASOCT enables reproducible detection with excellent intra- and inter-grader agreement. These findings support incorporation of ASOCT imaging into microbial keratitis evaluation protocols. Differences in round and flat endothelial plaque morphologies warrant further investigation.

#3

Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates.

Investigative ophthalmology & visual science2026 Jan 05

The purpose of this study was to evaluate the in vitro effects of combining rose bengal (RB) photodynamic antimicrobial therapy (PDAT) with conventional topical antifungals (amphotericin B, natamycin, and voriconazole) on clinical Fusarium and Aspergillus isolates and to determine the antifungal stability under experimental conditions. Clinical isolates of Fusarium spp. (n = 3) and Aspergillus spp. (n = 3) were cultured using standard microbiology techniques. Agar plates were prepared with three concentrations of amphotericin B, natamycin, or voriconazole along with plates containing no antifungals. The following groups were tested in both dark and light conditions: (1) antifungal monotherapy (antifungal only), (2) RB monotherapy (RB only), and (3) antifungal and RB combination therapy. Plates were incubated for 7 days and percent growth inhibition was quantified. UV-visible spectroscopy and mass spectrometry was performed to assess antifungal stability. Overall, Fusarium isolates were more susceptible to RB-PDAT than Aspergillus isolates. RB-PDAT combination therapy with natamycin reduced growth inhibition, whereas combination therapy with voriconazole increased growth inhibition compared to antifungal monotherapy. UV-visible spectroscopy demonstrated 70% degradation of amphotericin B and full degradation of natamycin when combined with RB-PDAT, whereas voriconazole remained stable. Across both Fusarium and Aspergillus isolates, treatment responses to antifungals with or without RB-PDAT demonstrated strain-specific effects. The increased fungal inhibition and maintained stability of voriconazole when combined with RB-PDAT highlight its potential compatibility with RB-PDAT. In contrast, the reduced inhibition and degradation of natamycin and amphotericin B with RB-PDAT suggests that drug stability may be a factor to consider when integrating RB-PDAT into fungal keratitis management.

#4

Ion-activated mucoadhesive in situ gel incorporating terbinafine-loaded NLCs promotes ocular penetration and retention for enhanced fungal keratitis therapy.

Materials today. Bio2026 Apr

Fungal keratitis (FK) is a sight-threatening infection with poor outcomes due to rapid tear clearance and insufficient corneal penetration. To overcome the limitations, we developed an ion-activated mucoadhesive in-situ gelling system (TH-NLC-ISG) integrating terbinafine-loaded nanostructured lipid carrier (TH-NLC) into a gellan gum/carboxymethyl chitosan matrix. The optimized formulation exhibited a particle size of 25.27 ± 0.75 nm. Upon contact with simulated tear fluid, the formulation underwent rapid sol-gel transition, achieving a 70-fold viscosity increase (34 °C, shear rate 1 s-1), critical for prolonged ocular residence. Fluorescence imaging demonstrated ocular retention of fluorescein sodium-labeled TH-NLC-ISG exceeding 60 min, significantly longer than the non-gelling control. In vivo pharmacokinetic studies revealed markedly improved ocular bioavailability, with higher area under the concentration in ocular tissues-time curve of TH in the TH-NLC-ISG group compared to TH-NLC. Corneal penetration studies confirmed that TH-NLC-ISG exhibited longer corneal retention time and higher corneal drug retention compared to TH-NLC. The formulation demonstrated excellent ocular biocompatibility in vitro and in vivo. TH-NLC-ISG exhibited potent in vitro antifungal activity against Fusarium solani. and Aspergillus flavus., with a lower MIC50 value than TH suspension. In rabbits and mice FK models, TH-NLC-ISG group achieved complete corneal healing, reduced clinical scores and corneal perforation rates, displaying efficacy superior to conventional natamycin eye drops. By synergistically augmenting retention and corneal permeation, TH-NLC-ISG provides a transformative strategy for enhanced fungal keratitis therapy.

#5

Severe fungal keratitis caused by Lasiodiplodia theobromae following grass trimmer-related ocular trauma: a case report.

Medical mycology case reports2026 Jun

Lasiodiplodia theobromae is an uncommon but emerging filamentous fungus primarily recognized as a plant pathogen. We report a case of severe L. theobromae keratitis in a 57-year-old man who presented with left eye pain, redness, and progressive visual loss following grass trimmer-related ocular trauma. Ocular examination revealed diffuse corneal haziness, dense stromal infiltrate, total epithelial defect, and descemetoceles. The organism was isolated from corneal scrapings and identified by microscopy, culture, MALDI-TOF mass spectrometry, and confirmatory ITS sequencing. Management required intensive topical, intravitreal, and systemic antifungal therapy in addition to surgical intervention. Visual acuity remained at light perception at three weeks postoperatively, with no further deterioration observed following combined surgical and medical management. Early diagnosis remains challenging due to overlapping morphological features with other filamentous fungi, necessitating molecular confirmation.

Publicações recentes

Successful Medical Management of Pigmented Fungal Keratitis Following Vegetative Trauma.

Ann Afr Med2026 Apr 17

Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway.

Phytomedicine2026 Apr 6

Ointment for Topical Ocular Delivery of Voriconazole: Formulation Development, In-Vitro Characterization & In-Vivo Pharmacokinetic Assessment.

Biopharm Drug Dispos2026 Apr 16

Electrostatic-tailored Leciplex system of ketoconazole for boosted ocular pharmacology and cytotoxicity assessment.

Naunyn Schmiedebergs Arch Pharmacol2026 Apr 15

Corneal Targeted Mucoadhesive Emulsion for Prolonged Delivery of Voriconazole: Formulation Evaluation and Pharmacokinetic Assessment.

Biopharm Drug Dispos2026 Apr 11

Ver todas no PubMed

📚 EuropePMC1.011 artigos no totalmostrando 197

Ion-activated mucoadhesive in situ gel incorporating terbinafine-loaded NLCs promotes ocular penetration and retention for enhanced fungal keratitis therapy.

Materials today. Bio

Medical mycology case reports

Severe fungal keratitis caused by Lasiodiplodia theobromae following grass trimmer-related ocular trauma: a case report.

Therapeutic Penetrating Keratoplasty for Aspergillus Fungal Keratitis: A Case Report.

Journal of infection and public health

Climate's eye: A 20-year study on climate and pollution impacts on fungal keratitis incidence.

Asian journal of pharmaceutical sciences

Overcoming corneal barriers: Posaconazole loaded cationic surfactant vesicles for enhanced ocular permeability and anti-fungal efficacy.

Bacterial and fungal keratitis in Northeast Mexico: demographic, predisposing, and microbiological differences among non-contact lens, optical contact lens, and bandage contact lens wearers.

Diagnostic Accuracy of a CRISPR-Based Assay in Smear- and Culture-Negative Fungal Keratitis.

JAMA ophthalmology

Ecotoxicology and environmental safety

Corneal transcriptomic signatures of mycotoxin exposure reveal distinct immune and metabolic responses.

Bridging Gaps in Fungal Keratitis Management: Novel Diagnostics, Drug Delivery Systems, and Gene Therapies.

AAPS PharmSciTech

Klinische Monatsblatter fur Augenheilkunde

Beyond the Hospital - Bacterial and Fungal Keratitis in Private Ophthalmic Care.

Advanced healthcare materials

Dual Ferroptosis-Inhibitory and Antifungal Therapy for Fungal Keratitis Using a Defect-Adhesive Thermoresponsive Hydrogel.

MMWR. Morbidity and mortality weekly report

Purpureocillium lilacinum Keratitis Outbreak Associated with an Ophthalmology Clinic - New York City, 2024.

Letter Regarding: Temporary Conjunctival Flap Plus Medical Treatment Versus Medical Treatment Only for High-Risk Fungal Keratitis: A Randomized Controlled Trial.

Isoimperatorin alleviates fungal keratitis by regulating NF-κB pathway and macrophage immune response.

Frontiers in immunology

medRxiv : the preprint server for health sciences

Detection of Endothelial Plaque in Microbial Keratitis Using Anterior Segment Optical Coherence Tomography.

A neutrophil membrane-biomimetic drug delivery system enhances the antifungal and anti-inflammatory efficacy of natamycin for fungal keratitis.

Biomaterials advances

Journal of nanobiotechnology

Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy.

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

[Advances in clinical diagnosis and treatment of pythium keratitis].

International journal of antimicrobial agents

Efficacy and Safety of Intracameral Amphotericin B for Fungal Keratitis: A Systematic Review and Meta-Analysis.

Pharmaceuticals (Basel, Switzerland)

Natamycin in Food and Ophthalmology: Knowledge Gaps and Emerging Insights from Zebrafish Models.

Journal of clinical medicine

Current Challenges and Long-Term Outcomes in Corneal Transplantation in Infectious Keratitis-A Systematic Review.

Fungal keratitis in Germany : Diagnostics, conservative and microsurgical treatment.

Die Ophthalmologie

IL-24 regulates corneal inflammation and fibrosis in fungal keratitis via the caspase-11/gasdermin D pathway.

Sennoside A alleviates fungal keratitis by modulating inflammation and immune responses through the caspase-1/GSDMD pathway.

Cytokine

Fungal keratitis following laser assisted lenticule extraction surgery with use of losartan as an anti-scarring agent - a case report.

Clinical Characteristics and Outcomes of Rare Fungal Keratitis Caused by Plectosphaerella cucumerina: A Retrospective Case Series Analysis.

Mycopathologia

Adjunctive tacrolimus in the treatment of fungal keratitis requiring therapeutic penetrating keratoplasty.

Duplex droplet digital PCR (ddPCR) improves the diagnosis of Aspergillus and Fusarium keratitis.

International journal of pharmaceutics

Eyes on the future: PVA-hydrogel lenses as a platform for amphotericin B ocular delivery.

Purpureocillium lilacinum Keratitis and Endophthalmitis in an Aphakic Eye With Secondary Glaucoma: A Case Report.

TLR9-mediated activation of the NLRP3 inflammasome in Fusarium solani-induced keratitis.

Ocular immunology and inflammation

Efficacy of 0.5% Voriconazole Subpalpebral Lavage as Adjunctive Therapy: A Multicenter Prospective Study in Fungal Keratitis Management.

Evaluating Photochemical Interactions Between Rose Bengal Photodynamic Antimicrobial Therapy and Topical Antifungals in Fungal Keratitis Isolates.

Translational vision science & technology

Pediatric Fungal Keratitis: Predisposing Factors, Clinical Features, and Outcomes During a 24-Year Study.

Green Light-Activated Rose Bengal Cross-Linking in 81 Horses With Complex Corneal Ulcers and Stromal Abscesses.

Veterinary ophthalmology

Argon Laser Phototherapy as an Adjunctive Treatment for Refractory Fungal Keratitis: A Retrospective Case Series.

Journal of visualized experiments : JoVE

Lipoic Acid Modulates Nrf2/HO-1 Pathway to Suppress Inflammation in Fungal Keratitis Through Host-Directed Cytoprotective Mechanisms.

Clinical ophthalmology (Auckland, N.Z.)

Renaissance of an Emerging Pathogen-Pythium insidiosum Keratitis: An Indian Perspective.

Clinical ophthalmology (Auckland, N.Z.)

Immune Camouflage in Pythium insidiosum Keratitis: A Hypothesis on Molecular Mimicry and Host Pattern Recognition Receptor Evasion.

Recovery and regeneration: exploring positive sequelae of keratitis.

Annales pharmaceutiques francaises

Ocular cationic nanocarrier-based delivery of posaconazole.

Unveiling rare fungal pathogens: clinical insights and molecular identification in fungal keratitis cases.

Healthcare technology letters

Ensemble Machine Learning Approaches for Automated Fungal Keratitis Diagnosis Using In Vivo Confocal Microscopy Images.

Frontiers in cellular and infection microbiology

PFKFB3 alleviates the advancement of Fusarium solani keratitis by attenuating macrophage inflammation.

Caspofungin-loaded dissolving microneedles for transcorneal delivery in fungal keratitis.

Journal of medical microbiology

Impact of biofilm formation in fungal corneal ulcers on treatment outcomes: a systematic review and meta-analysis.

MoS2-x/C Nanosheets for Antifungal and Anti-Inflammatory Therapy of Aspergillus fumigatus Keratitis in Mice.

An Interesting Case of Ocular Nocardiosis Mistaken as a Fungal Corneal Ulcer.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Ex Vivo Goat Corneal Model for Investigating Host Immune Responses and Antifungal Drug Testing in Fusarium Keratitis.

Seminars in ophthalmology

Distinguishing Fungal Keratitis from HSV Endothelial Keratitis: A Comparative Clinical and Diagnostic Analysis.

Clinical Outcomes of Rose Bengal Photodynamic Therapy for Severe Infectious Keratitis.

Comparing Microbiologic Tests for Pathogen Detection in Infectious Keratitis Using Latent Class Analysis.

Advanced healthcare materials

Cu-Single Atoms/Clusters-Nanoenzymes Trigger and Integrate Tandem Effect to Synchronously Boost Antifungal and Anti-Inflammation for Fungal Keratitis.

The British journal of ophthalmology

Efficacy of natamycin monotherapy versus combination therapy with voriconazole for fungal keratitis: a randomised clinical trial.

Drug delivery and translational research

Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis.

Lasers in surgery and medicine

Antimicrobial Blue Light for Treatment of Candida albicans Keratitis: Efficacy in Ex Vivo Rabbit Corneas and Safety Evaluation in Retinal Cells In Vitro.

First report of rare fungal keratitis: Diaporthe aspalathi.

Klinische Monatsblatter fur Augenheilkunde

First Reported Case of Fungal Keratitis Caused by Vishniacozyma victoriae.

International immunopharmacology

Baicalin ameliorates Aspergillus fumigatus keratitis by its antifungal activity and suppression of pyroptosis.

Antimicrobial agents and chemotherapy

Vitamin C enhances corneal fungal infection treatment in mice via chemotaxis and anti-inflammation.

Journal of clinical medicine

In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Optimizing Diagnosis and Therapeutic Management in Fungal Keratitis: Case Reports and Literature Review.

Clinical profile and outcomes of dematiaceous fungal keratitis - data from a secondary center in rural North India.

Journal of fungi (Basel, Switzerland)

A Rare Case of Alternaria citri Keratitis Successfully Treated with Voriconazole.

Beauveria bassiana keratitis - the first Hungarian case report.

Fungal keratitis: Does antifungal Resistance Influence the outcome?

Unusual presentation of fungal keratitis and endogenous endophthalmitis in Sézary syndrome: a case report.

Clinical & experimental optometry

A review of technological advances in the management of bacterial, fungal, viral, and Acanthamoeba keratitis.

Dysbiosis of bacterial and fungal microbiomes affects the disease process and treatment outcome in fungal keratitis.

Clinical features, microbiological characteristics, and treatment outcomes of fungal keratitis in a tertiary referral hospital in Eastern China.

BMC infectious diseases

Sanguinarine attenuates Aspergillus fumigatus keratitis by exerting antifungal and anti-inflammatory effects.

Journal of materials chemistry. B

Corneal retention using a nanorobot-based eyedrop.

Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial.

Scientific reports

A 3D Fusarium keratitis model reveals isolate-specific adhesion and invasion properties in the Fusarium solani species complex.

mSphere

Infectious Keratitis: A Tertiary Center's Approach to Diagnosis, Management, and Enhanced Outcomes Through Microbiological Analysis.

Microorganisms

Expert review of medical devices

Advancing diagnostics in Pythium insidiosum keratitis: the emerging role of point-of-care imaging and biosensor-based detection devices.

A Case Report and Global Perspective on Fusarium Superficial Keratitis in the Pediatric Population.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

Fungal Keratitis Caused by Alternaria alternata: A Rare Pathogen and Its Surgical Treatment.

Fusarium Corneal Abscess: A Case Report.

Journal de mycologie medicale

Molecular characterization and antifungal susceptibility profile of Podospora bulbillosa keratitis: case series and review of literature.

Fusarium solani Activates PANoptosis and Modulates Immune Response in Fungal Keratitis.

A Rare Case of Pseudomonas aeruginosa Keratoscleritis: Highlighting Early Diagnosis and Aggressive Treatment.

Not All Fungi and Games: An Unusual Case of Fungal Keratitis in Michigan.

Rosemary Essential Oil Microemulsion for Fungal Keratitis Treatment.

Chemistry & biodiversity

Pharmaceutical nanotechnology

Design and Evaluation of Econazole-Loaded Nanostructured Lipid Carriers for Ocular Treatment of Fungal Keratitis: In vitro and Ex vivo Studies.

Trypan blue staining for fungal keratitis diagnosis: a comparative study in rural India.

The Cochrane database of systematic reviews

Medical interventions for fungal keratitis.

Culture positivity of anterior chamber exudate in cases of fungal keratitis.

Nigrospora oryzae keratitis: a rare fungal etiology.

In Vitro Antifungal Activity of Amphotericin B-Encapsulated Silk Fibroin-Chitosan Nanoparticles Against Fusarium solani Isolates from Keratitis Patients.

Pharmaceutics

Predictors of vision-related quality of life in patients treated for filamentous fungal keratitis.

Journal of fungi (Basel, Switzerland)

Localized Versus Diffuse Corneal Invasion in Fungal Keratitis: Histological Insights from Candida albicans and Fusarium falciforme.

Scedosporium apiospermum and Lomentospora prolificans emergent ocular infections in North India.

Infection and drug resistance

Achaetomium luteum and Exserohilum rostratum, Two Rare Causes of Keratomycosis in China: Case Report.

Correlation between corneal concentration and minimum inhibitory concentration of antifungals in patients undergoing therapeutic keratoplasty for fungal keratitis.

Structure-Activity Relationship in ε-Lysine Peptides: The Length Effects on Antifungal Activity.

Biomacromolecules

The Journal of biological chemistry

SA-XV, a 15-amino acid fragment of host defense peptide S100A12, targets mitochondria and is protective against fungal infections.

Pre-Colonization of Bacillus siamensis on Ocular Surface Mitigates Fusarium keratitis Through Direct Antifungal Activity and Pre-Activation of NF-κB Pathway.

Fungal keratitis caused by Pyrenochaeta unguis-hominis: Identification and microbiological characteristics of a rare case.

IDCases

Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy.

Mycopathologia

First Isolation of a Multi-azole-Resistant Aspergillus fumigatus cyp51A TR46/Y46F/F70L Mutant in a Patient with Fungal Keratitis.

Mycopathologia

Journal of microbiological methods

Prospective study on combined use of Sabouraud dextrose agar and blood agar for improved recovery of etiological agents in mycotic and Pythium keratitis.

Aspergillus flavus Keratitis After Penetrating Keratoplasty.

The IL-36γ/PEDF/PPARγ signalling pathway plays an anti-inflammatory role in Candida albicans keratitis.

Scientific reports

Management of microbial keratitis by private pharmacies in Uganda: a study of knowledge, attitude, and practice.

Wellcome open research

Corrigendum to "New Biomarkers for Patients With Fungal Keratitis From Blood Routine Examination: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio".

Journal of ophthalmology

A case of rare fungal keratitis caused by Pseudoshiraia conidialis.

Medicine

Journal of nanobiotechnology

Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment.

Clinical recommendations for the management of Pythium insidiosum keratitis.

International journal of biological macromolecules

Healing efficiency of nystatin-loaded chitosan-guar gum-based nanocapsules in experimental fungal keratitis.

Detection of Fusarium solani using cutinase antibody and its application in diagnosing fungal keratitis in an animal model.

PloS one

Diagnostic Accuracy of Clinic-Based Loop-Mediated Isothermal Amplification and Quantitative PCR for Fungal and Acanthamoeba Keratitis.

Journal of controlled release : official journal of the Controlled Release Society

Reactive oxygen species mediate black phosphorus quantum dots assembled microneedle patches for keratitis therapy.

Medical hypothesis, discovery & innovation ophthalmology journal

Multilayered fresh amniotic membrane transplantation in resistant fungal corneal ulceration.

The pathogenesis, risk factors, diagnosis and treatment of Acanthamoeba keratitis.

Frontiers in medicine

Shikonin treats Aspergillus fumigatus keratitis by activating autophagy and reducing fungal load.

Artesunate Treats Aspergillus fumigatus Keratitis by Inhibiting Fungal Activity and Activating Autophagy Pathway to Reduce Corneal Inflammation.

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

[Pay attention to keratoconjunctivitis caused by microsporidia infection].

Adjunctive Topical Calcineurin Inhibitors During the Treatment of Fungal Keratitis: Practice Patterns and Opinions.

Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy.

Colloids and surfaces. B, Biointerfaces

Development of reactive oxygen species-sensitive polyethylene glycol-modified voriconazole-loaded nanomicelles for treating fungal keratitis.

Journal of advanced research

Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism.

Journal of family medicine and primary care

Cutaneous mucormycosis: Unveiling rare manifestations.

Rapid one-tube RPA-coupled CRISPR/Cas12a-based RID-MyC assay for the diagnosis of fungal keratitis.

Fungal keratitis: slow, relentless, and breaching.

Eye (London, England)

Unveiling purine metabolism targets in the pathogenesis of fungal Keratitis: A combined proteomics and metabolomics approach.

[Fungal keratitis in Germany : Diagnostics, conservative and microsurgical treatment].

Die Ophthalmologie

Frontiers in microbiology

Nanomedicine in fungal keratitis: current applications and future prospects.

Pyrenochaeta unguis-hominis-associated fungal keratitis: A rare case report with in vivo confocal microscopy findings.

Outcomes of anterior chamber wash with adjuvant intracameral and intrastromal voriconazole in deep stromal fungal keratitis with endoexudates - A retrospective study.

Toxicology in vitro : an international journal published in association with BIBRA

The protective mechanisms of glycyrrhizic acid for deoxynivalenol-induced toxicity in rabbit corneal stroma.

Ophthalmology and therapy

Climate Change and the Impact on Ocular Infectious Diseases: A Narrative Review.

Emerging ocular pathogen: multidrug-resistant Corynespora cassiicola in fungal keratitis: case series and literature review.

Evaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody.

Scientific reports

Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.

Comparative efficacy of intrastromal amphotericin B versus voriconazole in treating deep-stromal refractory fungal keratitis.

Nonresponding fungal keratitis: Hope with intrastromal injections.

Taiwan journal of ophthalmology

Purpureocillium lilacinum keratitis in a methamphetamine user: Case report.

Applied microbiology and biotechnology

Fabrication of nanozyme thixotropic anionic hydrogel for treating fungal keratitis by Dectin-1/p38 pathway.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Targeting fungal keratitis: In vivo efficacy of corneal-targeting and non-targeting peptides againstFusarium dimerum.

Journal of materials chemistry. B

ZIF-8-coated ZnO with pH-responsive natamycin release boosting the antifungal and anti-inflammation activity to treat fungal keratitis.

Exosomal let-7b-5p derived from Aspergillus fumigatus-treated human corneal epithelial cells promotes M1 macrophage activation via targeting SOCS-1.

Frontiers in immunology

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis.

Case reports in ophthalmology

Fungal Keratitis following the Application of Green Tea Bag Warm Compresses.

Frontiers in cellular and infection microbiology

Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host immune response in patients with fungal keratitis.

Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol.

Wellcome open research

Journal of materials science. Materials in medicine

Moderation of cross linkage of sodium alginate-polyethylene oxide films loaded with natamycin for treatment of Aspergillus fumigatus keratitis.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Rose Bengal-Assisted Photodynamic Antimicrobial Therapy for Keratitis.

Deep Fungal Stromal Keratitis After Cataract Surgery: A Case Report.

Alterations in ocular fungal microbiota in patients with fungal keratitis: a comparative study from coastal regions of Eastern China.

First report of Stemphylium lycopersici keratitis, a complex corneal infection case.

Itraconazole Loaded Micelle Based on Methoxy Poly(Ethylene Glycol)-Poly(D, L-Lactic Acid) for Ocular Drug Delivery: In vitro and in vivo Evaluation.

Clinical and microbiological profile of patients with fungal keratitis demonstrating unusual yeast-like structures in potassium hydroxide with calcofluor white preparation of corneal scraping.

Retrospective Review of Fungal Keratitis at Two Tertiary Hospitals in Perth, Western Australia Between 2006 and 2022.

Mycoses

Ocular immunology and inflammation

Exogenous Fungal Endophthalmitis: A 20-Year Experience at a Tertiary Referral Centre in North China.

Naunyn-Schmiedeberg's archives of pharmacology

Advancing fungal keratitis treatment: transitioning from conventional amphotericin B therapy to nanocarrier-based delivery systems.

Antimicrobial agents and chemotherapy

Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis.

Chitosan-Based Intelligent Microneedles for Delivery of Amphotericin B Loaded Oleosomes: Antifungal Ocular Patch Targeting for Effective Against Fungal Keratitis Using Rabbit Model via TLR4/NLRP3 Pathway.

Pathology-inspired collagen-binding thermosensitive micelle drops enable prolonged and efficient treatment of fungal keratitis.

Bioactive materials

Infection and drug resistance

A Rare Case of Keratitis Caused by Graphium basitruncatum in China.

Evolving indications and surgical trends in keratoplasty: a 7-year analysis from a Chinese tertiary referral center.

Fungal Keratitis Caused by Scedosporium apiospermum in an Immunocompetent Patient: How Challenging Can Treatment get?

The new microbiologica

Diagnostics (Basel, Switzerland)

Enhanced Detection of Bacterial Ocular Pathogens: A Comparative Study of Broad-Range Real-Time PCR and Conventional Culture Methods.

Frontiers in cellular and infection microbiology

Antifungal susceptibility and clinical efficacy of chlorhexidine combined with topical ophthalmic medications against Fusarium species isolated from corneal samples.

Antibiotics (Basel, Switzerland)

Therapeutic Efficacy of Ultraviolet C Light on Fungal Keratitis-In Vitro and Ex Vivo Studies.

Corneal cross-linking for infectious keratitis of various causes: an umbrella review.

Zeolitic Imidazolate Framework-90 Treats Fungal Keratitis by Promoting Macrophage Apoptosis and Targeting Increased Mitochondrial Reactive Oxygen Species in Aspergillus Fumigatus.

Alternative photosensitizer penetration depth evaluation in ex vivo human eyes for photodynamic antimicrobial therapy.

Therapeutic delivery

A case of corneal infection with Clonostachys rosea.

BMC infectious diseases

Bifunctional chemokine-nanobody fusion protein enhances neutrophil recruitment to impede Acanthamoeba immune evasion.

EBioMedicine

Keratomycosis: An insight into epidemiology, etiology, and antifungal susceptibility testing of causative agents at a tertiary care centre.

Medical mycology

Journal of the American Veterinary Medical Association

Corneal rupture in a 19-year-old Quarter Horse mare.

Predicting the causative agent in microbial keratitis: the role of anterior segment optical coherence tomography-a cross-sectional analysis.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Minimally invasive treatment of fungal keratitis with voriconazole microneedle corneal patch.

Pharmaceutical development and technology

Enhancing ocular drug delivery: development and in vivo evaluation of mucoadhesive nanostructured lipid carriers for terbinafine.

Translational vision science & technology

An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis.

Diagnostic microbiology and infectious disease

Investigating the susceptibility profiles and in vitro combinations of caspofungin, itraconazole, fluconazole, voriconazole, clotrimazole, and amphotericin B against clinical isolates causing fungal keratitis.

New Biomarkers for Patients With Fungal Keratitis From Blood Routine Examination: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.

Journal of ophthalmology

Crystalline Lens Extrusion Secondary to Fungal Keratitis.

Balkan medical journal

Computers in biology and medicine

Deep learning by Vision Transformer to classify bacterial and fungal keratitis using different types of anterior segment images.

International journal of pharmaceutics: X

Exploring the potential of antifungal-loaded proniosomes to consolidate corneal permeation in fungal keratitis: A comprehensive investigation from laboratory characterization to microbiological evaluation.

The therapeutic effect and mechanism of carnosic acid in Aspergillus fumigatus keratitis.

A masked study to differentiate in vivo confocal microscopic features of Pythium insidiosum and fungal filaments.

Journal of avian medicine and surgery

Evisceration as an Alternative to Enucleation in Four Pet Psittacine Birds.

Long Non-Coding RNA Osr2 Promotes Fusarium solani Keratitis Inflammation via the miR-30a-3p/ Xcr1 Axis.

Infection and drug resistance

Clinical Characteristics and Treatment Outcomes of Pediatric Fungal Keratitis.

Phosphoglycerate mutase and methionine synthase act as adhesins of Candida albicans to the corneal epithelium, altering their expression during the tissue adhesion process.

Rutin resists Aspergillus fumigatus keratitis by activating Nrf2/HO-1 pathway, inhibiting Dectin-1/p-Syk pathway and affecting fungal structures.

International journal for parasitology. Drugs and drug resistance

Recent in vitro advances in the ocular antimicrobial agents against Acanthamoeba.

Ultraviolet C (UV-C) Light Therapy for Equine Ulcerative Keratomycosis-An In Vitro Study.

Veterinary ophthalmology

SAA1 as a key mediator of immune inflammatory pathways in fungal keratitis through FOXO3a phosphorylation regulation.

Cytokine

Platelet membrane-camouflaged PLGA loaded natamycin improve the prognosis of fungal keratitis.

Biomaterials advances

International immunopharmacology

Piperine inhibits fungal growth and protects against pyroptosis in Aspergillus fumigatus keratitis by regulating the mTOR/HIF-1α pathway.

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis.

Diagnosis of microbial keratitis using smartphone-captured images; a deep-learning model.

Outcomes of a Tenon Patch Graft for Corneal Perforations in Resolving Infectious Keratitis.

Comparative analysis of the therapeutic efficacy of low-temperature plasma ablation in treating fungal keratitis caused by various strains.