Raras
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Brucelose
ORPHA:1304CID-10 · A23.3CID-11 · 1B95DOENÇA RARA

A brucelose é uma infecção bacteriana que passa de animais para pessoas. Isso acontece principalmente ao consumir laticínios não pasteurizados (que não foram aquecidos para matar as bactérias) ou pelo contato com produtos de animais contaminados ou com os próprios animais doentes. Os animais mais comumente infectados incluem ovelhas, gado, cabras, porcos e cachorros. A brucelose pode causar uma série de sinais e sintomas, e alguns deles podem durar bastante ou retornar. Os primeiros sintomas podem ser febre, suores, mal-estar geral, falta de apetite, dor de cabeça, cansaço e/ou dores nos músculos, nas juntas e/ou nas costas. Sintomas que podem durar muito tempo ou retornar incluem febre que vai e volta, artrite (inflamação nas juntas), inchaço no testículo e na bolsa escrotal, inchaço do coração (chamado endocardite), problemas no sistema nervoso (em até 5% dos casos), cansaço crônico, depressão e/ou inchaço do fígado ou do baço. Pessoas que trabalham ou vivem em ambientes onde há maior risco de entrar em contato com a bactéria têm um risco maior de contrair a infecção. A brucelose é tratada com antibióticos. A recuperação pode levar de algumas semanas a vários meses, e é comum que os sintomas retornem (recidivas). A morte por brucelose é rara, ocorrendo em no máximo 2% dos casos.

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Introdução

O que você precisa saber de cara

📋

A brucelose é uma infecção bacteriana que passa de animais para pessoas. Isso acontece principalmente ao consumir laticínios não pasteurizados (que não foram aquecidos para matar as bactérias) ou pelo contato com produtos de animais contaminados ou com os próprios animais doentes. Os animais mais comumente infectados incluem ovelhas, gado, cabras, porcos e cachorros. A brucelose pode causar uma série de sinais e sintomas, e alguns deles podem durar bastante ou retornar. Os primeiros sintomas podem ser febre, suores, mal-estar geral, falta de apetite, dor de cabeça, cansaço e/ou dores nos músculos, nas juntas e/ou nas costas. Sintomas que podem durar muito tempo ou retornar incluem febre que vai e volta, artrite (inflamação nas juntas), inchaço no testículo e na bolsa escrotal, inchaço do coração (chamado endocardite), problemas no sistema nervoso (em até 5% dos casos), cansaço crônico, depressão e/ou inchaço do fígado ou do baço. Pessoas que trabalham ou vivem em ambientes onde há maior risco de entrar em contato com a bactéria têm um risco maior de contrair a infecção. A brucelose é tratada com antibióticos. A recuperação pode levar de algumas semanas a vários meses, e é comum que os sintomas retornem (recidivas). A morte por brucelose é rara, ocorrendo em no máximo 2% dos casos.

Pesquisas ativas
2 ensaios
80 total registrados no ClinicalTrials.gov
Publicações científicas
13.661 artigos
Último publicado: 2026 Jun

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.09
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A23.3
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
9 sintomas
🩸
Sangue
7 sintomas
🦴
Ossos e articulações
5 sintomas
❤️
Coração
5 sintomas
🫁
Pulmão
5 sintomas
📏
Crescimento
3 sintomas

+ 34 sintomas em outras categorias

Características mais comuns

90%prev.
Anormalidade do fígado
Muito frequente (99-80%)
55%prev.
Hiperidrose
Frequente (79-30%)
55%prev.
Perda de peso
Frequente (79-30%)
55%prev.
Febre
Frequente (79-30%)
55%prev.
Anorexia
Frequente (79-30%)
55%prev.
Esplenomegalia
Frequente (79-30%)
80sintomas
Muito frequente (1)
Frequente (19)
Ocasional (39)
Muito raro (18)
Sem dados (3)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 80 características clínicas mais associadas, ordenadas por frequência.

Anormalidade do fígadoAbnormality of the liver
Muito frequente (99-80%)90%
HiperidroseHyperhidrosis
Frequente (79-30%)55%
Perda de pesoWeight loss
Frequente (79-30%)55%
FebreFever
Frequente (79-30%)55%
Anorexia
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico13.661PubMed
Últimos 10 anos200publicações
Pico2026128 papers
Linha do tempo
2026Hoje · 2026🧪 1994Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 4 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Brucelose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

80 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
4.427 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 4.427

#1

Brucella abortus and public health risk: Prevalence in milk sold at open markets in Cameroon.

PLoS neglected tropical diseases2026 Mar

Um estudo nos Camarões confirmou a presença de *Brucella abortus* no leite vendido em mercados abertos, revelando um risco direto e anteriormente não identificado de brucelose para a saúde pública geral. Aproximadamente 1.3% das amostras de leite continham a bactéria viva, impulsionado por práticas de comerciantes que misturam e raramente fervem o leite, resultando na exposição semanal de centenas de pessoas. Este achado é crucial para médicos, que devem considerar a brucelose em casos de febre de origem desconhecida, e para pacientes, que devem obrigatoriamente ferver todo o leite antes do consumo para prevenir a infecção.

🇧🇷 traduzido
#2

Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study.

PLoS neglected tropical diseases2026 Mar 20

Este estudo em Uganda revelou uma alta prevalência de brucelose (14%) em gestantes, uma zoonose que pode causar anemia, aborto espontâneo e parto prematuro. Os principais fatores de risco identificados foram o consumo de leite fresco ou carne malpassada, o contato frequente com esterco animal e a criação de gado em casa. Para pacientes e médicos, é crucial integrar o rastreamento de brucelose na rotina pré-natal e promover a pasteurização do leite, o preparo seguro da carne e melhorias na higiene para reduzir infecções maternas e complicações na gravidez.

🇧🇷 traduzido
#3

ASAP1 gene InDel variants are associated with enhanced goat resistance against Brucella infection.

Animal bioscience2026 Mar 11

Este estudo em cabras identificou que variantes genéticas específicas (P2 e P7) e certos haplótipos do gene ASAP1 estão associadas à resistência ou suscetibilidade à infecção por Brucella. Cabras com os haplótipos resistentes (Hap3 e Hap5) demonstraram maior expressão do gene ASAP1 e uma resposta inflamatória mais acelerada e robusta contra a infecção. Esses achados fornecem uma base teórica para o melhoramento genético de cabras, visando criar populações mais resistentes à brucelose e, consequentemente, reduzir a prevalência da doença em animais e o risco de transmissão para humanos.

🇧🇷 traduzido
#4

Socioeconomic drivers of human Brucellosis in Ningxia, China: A one health and spatiotemporal analysis for targeted intervention.

PLoS neglected tropical diseases2026 Mar 16

Este estudo em Ningxia, China, revelou um aumento alarmante de 167 vezes na incidência de brucelose humana entre 2007 e 2022, com focos de alto risco persistentes em 11 condados orientais. Os principais impulsionadores são fatores relacionados à pecuária (rebanhos de ovinos e bovinos), com efeitos de risco que podem se manifestar anos após a exposição, enquanto um maior desenvolvimento econômico regional mostrou associação imediata com menor risco. Para médicos e pacientes, isso sublinha a importância de medidas de saúde pública veterinária focadas em áreas de risco e do aproveitamento do desenvolvimento econômico para fortalecer a prevenção e o controle a longo prazo.

🇧🇷 traduzido
#5

Seroprevalence and Associated Risk Factors of Brucellosis in Backyard Dairy Cattle in the Western Buffer Zone of Chitwan National Park, Nepal.

Veterinary medicine and science2026 Mar

Este estudo detectou brucelose bovina, uma doença zoonótica com potencial de transmissão para humanos, em 1.6% do gado leiteiro de criação doméstica em uma importante região produtora de leite no Nepal. Para pacientes e médicos, isso significa um risco potencial de infecção para humanos através de produtos lácteos não pasteurizados, sublinhando a necessidade de maior conscientização sobre a doença e sua epidemiologia para proteger a saúde pública.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC8.835 artigos no totalmostrando 198

2026

Brucella abortus and public health risk: Prevalence in milk sold at open markets in Cameroon.

PLoS neglected tropical diseases
2026

Brucellosis Complicated by Thyroid Abscess and Life-Threatening Hemophagocytic Syndrome: A Case Report.

Infection and drug resistance
2026

Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study.

PLoS neglected tropical diseases
2026

ASAP1 gene InDel variants are associated with enhanced goat resistance against Brucella infection.

Animal bioscience
2026

Natural history of latent brucellosis and diagnostic performance of B-SPOT: a 24-month prospective cohort study based on large-scale screening in northern China.

Emerging microbes &amp; infections
2026

Brucellosis vaccine development: immunological mechanisms, animal models, and future directions.

Archives of microbiology
2026

Establishment of a rapid Brucella detection method based on MCDA-CRISPR dual signal amplification system for reducing transfusion-transmitted diseases.

Scientific reports
2026

Socioeconomic drivers of human Brucellosis in Ningxia, China: A one health and spatiotemporal analysis for targeted intervention.

PLoS neglected tropical diseases
2026

Socio-economic impact of bovine brucellosis and the need for effective control strategies.

Veterinary research communications
2026

Seroprevalence and Associated Risk Factors of Brucellosis in Backyard Dairy Cattle in the Western Buffer Zone of Chitwan National Park, Nepal.

Veterinary medicine and science
2026

Risk Assessment and Management of Brucella canis Introduction via Commercial Dog Imports Into France.

Risk analysis : an official publication of the Society for Risk Analysis
2026

Evaluation of the relationship between signal time in blood cultures and clinical findings in brucellosis cases.

Diagnostic microbiology and infectious disease
2026

Differentiating scrub typhus meningitis from brucellar meningitis in children: A single-center retrospective study.

PLoS neglected tropical diseases
2026

Successful Conservative Management of Complicated Brucella Endocarditis.

Journal of medical cases
2026

Clinical and Laboratory Profile of Patients with Tropical Coinfections Admitted at a Tertiary Care Center in North India.

The Journal of the Association of Physicians of India
2026

Human Health Risk Assessment of Informal Slaughter by Small-Scale Farmers in Gauteng Province, South Africa, Focusing on Brucella abortus.

Veterinary medicine international
2026

Hollow viscus perforation secondary to brucellosis: a rare case report.

International journal of surgery case reports
2026

Serological evaluation of brucellosis in nomadic small ruminants in Southeastern Türkiye.

BMC veterinary research
2026

Analysis of Bacteremic Brucellosis Caused by Brucella melitensis Biovar 3 vs. Non-Bacteremic Cases in an Endemic Region of Türkiye.

Infectious diseases &amp; clinical microbiology
2026

The ID Screen® Brucella suis Indirect ELISA is a valuable supplement for serological diagnosis of porcine brucellosis.

Schweizer Archiv fur Tierheilkunde
2026

Conjunctival administration of H38ΔwbkF rough vaccine as an effective strategy to protect against Brucella ovis infection while minimizing serological interference.

Veterinary research
2026

Bovine brucellosis seropositivity in Mpumalanga Province, South Africa, 2021-2024: Temporal, and spatial trends.

PloS one
2026

From tests to truth: A misclassification-aware machine learning framework for estimating brucellosis seroprevalence in wild canids.

PLoS neglected tropical diseases
2026

Spatial characteristics and driving factors of human brucellosis and plague infections in the Meriones unguiculatus plague focus in China.

One health (Amsterdam, Netherlands)
2026

A case report of cervical spine epidural abscess caused by brucellosis.

Surgical neurology international
2026

Frequency and Etiologies of Peripheral Type Cranial Neuropathy in the Neurology Inpatient Clinic.

Noro psikiyatri arsivi
2026

Osteoarticular involvement in pediatric brucellosis: A 15-year retrospective study from a tertiary care pediatric hospital.

Journal of tropical pediatrics
2025

Prevalent Infectious Causes of Abortion in the Ruminant Population in Iran- A Literature Review.

Archives of Razi Institute
2026

Neurobrucellosis: An Uncommon but Important Cause of Sensorineural Hearing Loss: a case report.

Journal of otology
2026

Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.

The Journal of biological chemistry
2026

Meta-analysis of brucellosis and relative risks.

Medicine
2026

Genome-wide comparison analysis of Brucella attenuated vaccine strain BA0711 and Brucella wild-type strain M28 and establishment of a duplex qPCR differentiation method.

Veterinary journal (London, England : 1997)
2026

A rare complication in humans of a rare disease in Germany: a case of bilateral tubo-ovarian abscesses caused by Brucella melitensis.

Infection
2026

Development and Validation of a Population Assay for the Seroprevalence of Lumpy Skin Disease.

Microorganisms
2026

Diagnostic Value of Mean Platelet Volume and Hematological Inflammatory Ratios in Brucellosis: A Case-Control Study.

Life (Basel, Switzerland)
2026

Development and Evaluation of Multiple Droplet Digital PCR Method for Specific Detection and Differentiation of Brucella melitensis and Brucella abortus.

Animals : an open access journal from MDPI
2026

First report of the isolation, characterization, and genotyping of Brucella abortus biovar 9 in Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2026

Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens.

Vaccines
2026

Brucellosis in Kazakhstan: Knowledge, Attitudes, and Practices Among Smallholder Farmers and Veterinary Specialists.

Veterinary sciences
2026

Demyelinating Neurobrucellosis Presenting With Neuropsychiatric Manifestations.

Case reports in medicine
2026

Spatiotemporal Early Warning of Human Brucellosis in Hubei Province Using Coupled Ecological-Time Series Models.

Zoonoses and public health
2026

Congenital brucellosis in a preterm infant: A case report from France and literature review.

IDCases
2026

Tuft-cell-derived IL-25 regulates intestinal ILC2 in response to Brucella infection.

Frontiers in immunology
2026

Myeloid-derived suppressor cells and their subsets serve as potential biomarkers for the progression of brucellosis.

Frontiers in microbiology
2026

Biological characteristics, human cell interaction mechanisms, and differential clinical outcomes of infection by Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis.

Archives of microbiology
2026

A multi-source data-based modelling study on brucellosis transmission risk analysis and control strategies in Zhejiang Province, China.

BMC infectious diseases
2026

First isolation and molecular confirmation of Brucella canis in dogs from Egypt.

BMC microbiology
2026

Spinal brucellosis - A mimicker of spinal tuberculosis: An analysis of 10 patients from a tertiary care center in India.

Journal of craniovertebral junction &amp; spine
2026

Neurobrucellosis presenting with concurrent paraplegia and global aphasia in an elderly butcher: A case report and literature review.

IDCases
2026

Comprehensive analysis of molecular immunological characteristics and potential biomarkers in brucellosis.

Frontiers in immunology
2026

Blood culture positivity and its clinical determinants among hospitalized male patients with newly diagnosed, laboratory-confirmed brucellosis: a hospital-based retrospective study.

Frontiers in microbiology
2026

Prevalence and risk factors of neglected zoonoses in Ethiopian small ruminants: a focus on Q fever, brucellosis, chlamydiosis, and toxoplasmosis.

One health outlook
2026

Evaluation of brucellosis eradication strategies in water buffalo in a key dairy production area of southern Italy.

Frontiers in microbiology
2026

"MLVA_5: A reduced marker scheme for phylogeographic analysis of Brucella canis".

Comparative immunology, microbiology and infectious diseases
2026

Brucellar Spondylodiscitis 20 Years Post Infection.

The American journal of tropical medicine and hygiene
2026

Development of serologic diagnostic test based on in silico predicted synthetic peptides for Brucella canis in dogs.

PloS one
2026

Sensitivity of current laboratory methods for brucellosis diagnosis at endemic foci.

BMC microbiology
2025

Infectious disease burden and surveillance challenges in Jordan and Palestine: a systematic review and meta-analysis.

Frontiers in digital health
2025

Knowledge, attitudes, and practices among livestock owners, traders, and slaughterhouse inspectors in Cameroon reveals marginal understanding of livestock and human brucellosis.

Frontiers in veterinary science
2025

Assessment of Brucellosis Seropositivity in Patients Diagnosed with Tularemia.

Journal of clinical practice and research
2026

Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host.

Frontiers in immunology
2026

Corrigendum to "Integrated bioinformatics and machine learning deciphering IL12RB2 and FYN as key immune biomarkers in brucellosis" [Int. Immunopharmacol. 173 (2026) 116268].

International immunopharmacology
2026

Prioritization of zoonotic diseases in Bhutan through a One Health framework.

One health outlook
2026

Brucella's Emerging Threat: A Global Systematic Review and Meta-Analysis Revealing Temporal, Geographic and Species-Specific Patterns of Antimicrobial Resistance.

Veterinary medicine international
2026

An 18-year retrospective analysis of changing patterns in pediatric brucellosis in Jinan, China.

Scientific reports
2026

Development of a cELISA based on a trivalent nanobody-HRP fusion protein targeting BP26 for brucellosis diagnosis.

Talanta
2026

Predictors of Brucella spp. bacteraemia at admission among adults with brucellosis: a two-centre retrospective cohort study in Ningxia, China.

BMC infectious diseases
2026

Brucella-infected macrophage-derived microparticles enhance the host anti-Brucella acquired immune response.

Veterinary microbiology
2026

Evaluation of Humoral and Cellular Immune Responses to the Conjunctival Brucella abortus S19 Vaccine in Türkiye.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

Assessing human brucellosis infection rates in high-risk occupational groups.

Journal of infection in developing countries
2026

The Brucella abortus A19ΔfeuPΔfeuQ double-mutant is highly attenuated and confers protection in BALB/c mice.

Vaccine
2026

Seroprevalence and Associated Factors of Camel and Human Brucellosis in Dire District, Southern Ethiopia: A One-Health Perspective.

Veterinary medicine and science
2025

Evolution and phylogenetic characteristics of the first Brucella canis strain isolated from a human patient in Yunnan Province, China.

Frontiers in cellular and infection microbiology
2025

The impact of STING signaling on myeloid cells highlights macrophages as the major player in controlling Brucella abortus.

Frontiers in immunology
2026

The genome of Phlebotomus chinensis, the primary vector of visceral leishmaniasis in China: insights from chromosome-level assembly and comparative analysis.

Infectious diseases of poverty
2026

Brucella vs. tuberculous central nervous system infection in a tertiary medical center in Lebanon: A case series.

Journal of infection and public health
2026

Study on the detection method of Brucella differential type PCR.

Veterinary immunology and immunopathology
2026

Brucella brain abscess: a rare but serious neurological complication-case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2026

Brucella abortus histidine auxotrophs are copper sensitive.

Journal of bacteriology
2026

Prevalence and spatial distribution characteristics of human brucellosis in Ningxia from 2010 to 2024.

PLoS neglected tropical diseases
2025

Molecular identification of Brucella abortus in secondary hosts of goats and sheep in Magelang, Central Java, Indonesia.

Open veterinary journal
2025

The effect of a community intervention based on protection motivation theory on brucellosis preventive behaviors in rural residents.

Journal of education and health promotion
2026

Towards Integrated Surveillance of Marine Brucellosis: Diagnostic and Phylogenetic Assessment of Brucella ceti in Stranded Dolphins of the Western Mediterranean Sea.

Transboundary and emerging diseases
2026

Enhancing WSI image classification with graph convolutional neural networks and model uncertainty modeling.

BMC medical imaging
2025

Development of One Health-based community surveillance system to study zoonotic diseases: a study protocol.

Frontiers in public health
2026

An unusual case of neurobrucellosis with intracranial hypertension and bilateral abducens nerve palsy.

BMC infectious diseases
2026

TANK-binding Kinase 1 regulates the intracellular survival of Brucella.

Veterinary microbiology
2026

Integrated bioinformatics and machine learning deciphering IL12RB2 and FYN as key immune biomarkers in brucellosis.

International immunopharmacology
2026

Neurobrucellosis in an 11-year-old child: A rare case report of brain microabscesses from an endemic region.

The Journal of international medical research
2026

Phylogeny-guided multi-epitope vaccine design targeting conserved and divergent regions of Brucella OMP2, OMP25, and OMP31: an immunoinformatics study.

BMC immunology
2026

Brucella, Coxiella, and Theileria Species DNA in Haemaphysalis qinghaiensis Ticks Collected from Goats and Sheep in Qinghai Province, Northwest China.

Tropical medicine and infectious disease
2026

Brucellosis Presenting as Cavitary Pneumonia with Multiple Pulmonary Nodules: A Rare Presentation.

Annals of African medicine
2026

Cervical brucellar spondylitis: Current management strategies and future directions.

Infectious medicine
2025

Spatiotemporal dynamics of Brucella immune evasion across infection stages.

Frontiers in immunology
2026

Identification and Characterization of Outer Membrane Proteins and Membrane Spanning Protein Complexes in Brucella melitensis.

Proteins
2026

Dihydroartemisinin-Loaded ZIF-8 Nanoparticles for Antibacterial and Osteogenic Dual Therapy in Brucella-Infected Bone Defects.

ACS applied materials &amp; interfaces
2025

Two Years, Many Clues: Diagnostic Journey and Treatment of Chronic Neurobrucellosis in an Elderly Woman.

Cureus
2026

Novel metabolic adaptation driven by glycoside hydrolase family 25 protein contributes to increasing trimethoprim-sulfamethoxazole resistance in clinical human Brucella melitensis isolates in China.

Antimicrobial agents and chemotherapy
2025

Neurobrucellosis presenting as acute stroke with brain abscesses: a case report.

American journal of neurodegenerative disease
2026

BvrR From Brucella abortus Induces Neuroinflammation Through IRE1-Mediated Activation of ATF2 and NF-κB.

MicrobiologyOpen
2026

Genomic analysis of Brucella Ovis in Italy reveals high genetic diversity and a novel lineage.

BMC veterinary research
2026

Nanozyme antibiotic dressings to accelerate wound healing through anti-inflammatory and antibacterial effects.

Materials today. Bio
2026

Seroprevalence and risk factors for Brucella species and Coxiella burnetii exposure in a cross-sectional serosurvey of occupationally exposed groups in peri-urban Lomé, Togo.

PLoS neglected tropical diseases
2026

Metabolic map of Brucellosis: From acute and chronic phase adaptation to targeted nanodrug design.

Materials today. Bio
2025

MAJOR LIVESTOCK-ASSOCIATED ZOONOSES IN MONGOLIA: AN OVERVIEW.

Zoonoses (Shannon, Ireland)
2026

Research on rapid diagnosis of human brucellosis based on serumer transform infrared spectroscopy combined with machine learning algorithms.

Talanta
2026

Multi-Pathogen Knee Infection, Including Treponema pallidum and Brucella: A Case Report.

The American journal of case reports
2026

Integrated in vivo and in silico analysis of immune gene expression in cattle infected with Brucella abortus.

Scientific reports
2026

Assessing the spatiotemporal dynamics and driving factors of human brucellosis in Northern Xinjiang, China (2015-2023).

Tropical medicine and health
2026

A novel loop-mediated isothermal amplification assay coupled with lateral flow assay for differential detection of Brucella spp from Brucella abortus S19 vaccine strain.

Veterinary research communications
2026

Isolated intracranial hypertension in neurobrucellosis.

Tropical doctor
2026

A subset of type 4 secretion system effectors of Brucella spp. associates to outer membrane vesicles.

microLife
2025

Brucella as the main cause of abortion among livestock in Armenia.

Journal of infection in developing countries
2026

Correlation analysis between the prevalence of hyperuricemia and the triglyceride-glucose index in adult patients with brucellosis.

BMC infectious diseases
2026

Brucella melitensis sacroiliitis as an unusual culprit for fever of unknown origin (FUO).

BMJ case reports
2026

All spinal infections are not always tuberculosis: A rare case of brucella spondylodiscitis in South India.

Diagnostic microbiology and infectious disease
2025

[Pathogenetic and therapeutic approaches to the correction of neurocognitive disorders in patients with chronic brucellosis].

Terapevticheskii arkhiv
2026

Intraretinal Abscess in Ocular Brucellosis: A Rare and Unusual Manifestation.

Ocular immunology and inflammation
2025

Comparative analysis of Brucella melitensis whole cell proteomes for diagnosis of human brucellosis.

The Indian journal of medical research
2025

Comparison of bacteraemic & non-bacteraemic brucellosis: A retrospective analysis of 2 years.

The Indian journal of medical research
2026

Antimicrobial treatment of Brucella-infected prosthetic knee with sinus tract: A case report.

Medicine
2026

Brucellosis involving the aorta and iliac arteries: a single-center experience.

BMC infectious diseases
2026

Detection of Brucella spp. in compost-bedding pack barn and its relationship with infections in dairy cows during the transition period.

Research in veterinary science
2026

Comparison of serological tools for reliable diagnosis of brucellosis circulation in the West-African context.

BMC veterinary research
2026

Impact of nonpharmaceutical interventions on infectious disease patterns in Yunnan Province across the COVID-19 pandemic phases.

BMC infectious diseases
2026

Spatiotemporal trends and risk factors of small-ruminant brucellosis in China: A systematic review and meta-analysis.

Veterinary journal (London, England : 1997)
2026

Evaluation of residual virulence and protective efficacy for Brucella melitensis vaccine strain M5-90 in mice and guinea pigs.

Veterinary microbiology
2026

Fatal brucellosis presenting with multi-organ dysfunction and leukaemoid reaction: A case report.

Tropical doctor
2026

Concurrent neurobrucellosis and central nervous system aspergillosis in an immunocompetent host: a case report.

Journal of medical case reports
2026

Pediatric brucellosis with negative serology: Molecular confirmation and implications for epidemiological surveillance in Mexico.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Intraoperative Transmission of Brucellae.

Emerging infectious diseases
2026

Brucella abortus infection exploits ZDHHC3-mediated STAT3 palmitoylation to regulate host responses and promote persistence.

Veterinary research
2026

Strengthening brucellosis prevention and control in Iran: policy priorities informed by stakeholder networks, agenda-setting dynamics, and economic burden evidence.

Tropical medicine and health
2026

Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus.

Proteins
2026

Is the Course of Brucella Infections in Infancy Unexpectedly Benign?

The Pediatric infectious disease journal
2026

Unilateral septic sacroiliitis caused by Brucella Melitensis in the postpartum period: A rare case report.

IDCases
2025

Disruption of purine de novo synthesis pathway impairs membrane homeostasis, intracellular survival, and virulence of Brucella melitensis.

Frontiers in microbiology
2026

Development of Visual and Fluorescence Detection Method of Brucella by RPA-CRISPR/Cas12a Assay.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2025

Scoping review of brucellosis in Armenia: persistent neglect, significant knowledge gaps, and a necessity for innovative research, surveillance, and control.

Frontiers in veterinary science
2025

Assessment and Management of the Impact of Bovine Brucellosis on Dairy Herd Performance and Profitability.

Veterinary sciences
2025

Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.

Pathogens (Basel, Switzerland)
2025

Impact of the "Class B infectious disease Class B management" policy on the number of cases and deaths of notifiable infectious diseases in China during the COVID-19 epidemic: a nationwide interrupted time series study.

BMC public health
2025

Comparative genomics of Brucella species reveals key determinants of secondary metabolism, antimicrobial resistance, and virulence.

Scientific reports
2025

Design of a Prospective Human-Animal Cohort Study to Evaluate the Role of Camels and Other Livestock Species in the Transmission of Brucella spp. to Humans in Kenya.

International journal of environmental research and public health
2025

Brucella melitensis clinical isolate modulates osteoclast differentiation to drive pathological bone destruction in brucellar arthritis.

Frontiers in cellular and infection microbiology
2025

Typhoidal tularemia with pancytopenia and pericarditis in a georgian adolescent.

IDCases
2025

Evaluation of a competitive ELISA for detecting the anti-Brucella antibodies in serum and milk of goats and cattle.

Veterinary research communications
2026

Successful endovascular and open repair for brucellosis-associated multiple pseudoaneurysms.

European heart journal
2026

OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection.

International journal of biological macromolecules
2025

Complete genome assembly and functional characterization of Brucella melitensis strain IMHB1 from a clinical isolate in Inner Mongolia, China.

Frontiers in cellular and infection microbiology
2025

Comprehensive comparative analysis of explainable deep learning model for differentiation of brucellar spondylitis and tuberculous spondylitis through MRI sequences.

European journal of medical research
2025

[Epidemiological characteristics and spatial clustering of human brucellosis in Hunan Province, 2016-2024].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2025

Immunogenicity of a Lipopolysaccharide Brucella melitensis Vaccine in Goats: An Exploratory Study.

Vaccines
2025

Integrated Surveillance for Human and Animal Brucellosis in Kenya: A Predictive Analysis.

Tropical medicine and infectious disease
2025

Bacillary Layer Detachment Associated with Ocular Brucellosis.

Ophthalmology. Retina
2025

A Rare Case of Splenic Infarction Due to Brucellosis.

The new microbiologica
2025

Brucellosis uveitis: A case report and literature review.

Medicine
2025

A novel diagnostic model for brucellosis spondylitis using serum PINP and inflammatory factors: a dual-cohort study from Northwest China.

BMC infectious diseases
2026

Mechanism of Brucella pathogenesis mediated by outer membrane protein Omp19: Synergistic activation of cytokine storm and dual apoptotic pathways.

Microbial pathogenesis
2025

Transforming One Health in India: National Multisectoral Mixed Method Study on Prioritization of Zoonotic Diseases.

JMIR public health and surveillance
2025

Case Report: Peritoneal dialysis-associated peritonitis caused by Brucella.

Frontiers in medicine
2025

Development and evaluation of novel Brucella diagnostic antigen protein ST.

BMC infectious diseases
2025

Seroprevalence of brucellosis in humans and livestock in Sub-Saharan Africa: a systematic review and meta-analysis.

Systematic reviews
2026

First confirmation of Mycobacterium tuberculosis complex from medieval Ireland by aDNA analysis - palaeopathological and microbial findings.

Tuberculosis (Edinburgh, Scotland)
2025

[Evaluation of Gradient-Variant Quantum Dot Fluorescence Technology for Rapid Detection of Brucella].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
2025

First documented case of equine brucellosis in Libya: a case report.

Journal of equine science
2025

Spatial and Temporal Distribution of Febrile Illnesses in Uganda: Case Studies of Brucellosis, Malaria and Typhoid Fever (2016-2023).

Journal of tropical medicine
2026

Clinical and mechanistic insights into Brucella and viral co-infection.

Current opinion in virology
2025

Clinical Differences Between Culture-positive and Culture-negative Brucellosis in Childhood: A Single-center Experience.

The Pediatric infectious disease journal
2025

Brucellosis complicated by aortitis and thyroiditis: a case report.

BMC infectious diseases
2025

A new member of the novel, non-core Brucella clade: An exotic frog isolate closely related to atypical Brucella isolates from recent human brucellosis cases in Australia.

BMC microbiology
2025

Clinical Features and Treatment Differences Among Tuberculous, Brucellosis, and Pyogenic Spondylitis: A Cohort Study.

Infection and drug resistance
2025

Epidemiological baseline of Brucella spp. in South African wildlife.

PLoS neglected tropical diseases
2025

The European Union One Health 2024 Zoonoses Report.

EFSA journal. European Food Safety Authority
2025

Preliminary Retrospective Analysis of X-Ray, CT, and MRI Imaging Features of Brucellar Spondylodiscitis Diagnosis.

Journal of inflammation research
2025

Ecological study of human brucellosis in Iran from 2000 to 2023 and the limited role of climatic factors.

Scientific reports
2025

The Brucella type IV secretion system and effector proteins.

microLife
2025

Giant intracranial Brucella abscess after head trauma: a Case Report of neurobrucellosis in an urban elderly male without exposure history.

Frontiers in medicine
2025

A case report of hemophagocytic syndrome induced by Brucella melitensis biovar 3.

Frontiers in immunology
2025

Epidemiological analysis of infectious diseases in older people in China from 2014 to 2022: a population-based study.

The Lancet regional health. Western Pacific
2025

First documented case of cutaneous anthrax and brucellosis coinfection in a human in rural northern China: a case report.

BMC infectious diseases
2025

The synergistic pathogenic mechanism of Brucella melitensis M5-90 effector protein BspC in regulating host cell apoptosis, inflammation and oxidative stress.

Journal of medical microbiology
2025

Machine learning-based prediction model for chronic brucellosis: a multi-feature approach using clinical and laboratory data.

Frontiers in cellular and infection microbiology
2026

Antimicrobial and therapeutic effect of gold Nanoparticle-Aptamer conjugated antimicrobial peptide RW-BP100 in Brucella canis infected mice and RAW 264.7 cells.

Microbial pathogenesis
2025

Multiepitope fusion protein-based ELISA for enhanced brucellosis serodiagnosis.

PLoS neglected tropical diseases
2025

Biosecurity practices on small-ruminant farms in five Turkish provinces: a cross-sectional survey with multiple correspondence analysis.

Frontiers in veterinary science
2025

Global research hotspots and trends in brucellosis: a bibliometric and visualization analysis based on CiteSpace and VOSviewer.

Frontiers in medicine
2025

Musculoskeletal brucellosis presenting as low back pain and a limp.

QJM : monthly journal of the Association of Physicians
2025

Camel brucellosis: a narrative review of epidemiology and control strategies.

Veterinary research communications
2025

Case Report: Next-generation metagenomic sequencing in the diagnosis of Brucella-associated joint infections-a case series analysis and comprehensive literature review.

Frontiers in medicine
2025

Single-cell transcriptomics reveals dynamic reprogramming of testicular immunity in Brucella-infected goat testis.

Zoological research
2025

Geographic distribution and genetic diversity of Brucella melitensis from Yunnan province, China.

BMC microbiology
2025

Knowledge, attitude, and practice regarding brucellosis among confirmed cases.

Scientific reports
2025

Exploring community-based reporting of livestock abortions for rift valley fever and brucellosis surveillance in Uganda: a pilot study.

Scientific reports
2025

Protocol for a randomized controlled trial on the impact of a health action process approach model-based mobile health intervention via WeChat on health behaviors of brucellosis patients.

Frontiers in public health
2025

The economic burden of brucellosis in Western Iran.

Tropical medicine and health
2026

Brucellosis prevention and control in small ruminants using a test and slaughter strategy in the pastoral Afar Region of Ethiopia: A pilot study.

Preventive veterinary medicine
2025

Untargeted metabolomics pilot study using UHPLC-Q-Orbitrap to investigate potential metabolic markers of Brucella abortus biovars.

Analytical methods : advancing methods and applications
Ver todos os 8.835 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Brucella abortus and public health risk: Prevalence in milk sold at open markets in Cameroon.
    PLoS neglected tropical diseases· 2026· PMID 41871117mais citado
  2. Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study.
    PLoS neglected tropical diseases· 2026· PMID 41860883mais citado
  3. ASAP1 gene InDel variants are associated with enhanced goat resistance against Brucella infection.
    Animal bioscience· 2026· PMID 41856082mais citado
  4. Socioeconomic drivers of human Brucellosis in Ningxia, China: A one health and spatiotemporal analysis for targeted intervention.
    PLoS neglected tropical diseases· 2026· PMID 41838756mais citado
  5. Seroprevalence and Associated Risk Factors of Brucellosis in Backyard Dairy Cattle in the Western Buffer Zone of Chitwan National Park, Nepal.
    Veterinary medicine and science· 2026· PMID 41830525mais citado
  6. One health perspectives on the epidemiological features and changing incidence of natural focus and vector-borne infectious diseases in China: An observational trend study.
    One Health· 2026· PMID 41993771recente
  7. Construction of an RAA-CRISPR detection platform for differentiation of Brucella abortus A19-∆VirB12 vaccine strain from wild-type strains.
    J Microbiol Methods· 2026· PMID 41985719recente
  8. Epidemiological characteristics of brucellosis in non-occupational population in Zhejiang Province, China, 2018-2024: epidemic trend and infection analysis.
    One Health Outlook· 2026· PMID 41981446recente
  9. The clinical Epidemiological Characteristics and Diagnosis/Treatment of Brucellosis infection Patients in Gansu Province: A retrospective study from 2019 to 2022.
    BMC Infect Dis· 2026· PMID 41981383recente
  10. Development and validation of a VirB12-based indirect ELISA for differentiating Brucella abortus infection from A19-ΔVirB12 vaccination.
    J Microbiol Methods· 2026· PMID 41966411recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1304(Orphanet)
  2. MONDO:0005683(MONDO)
  3. GARD:5966(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q156050(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Brucelose
Compêndio · Raras BR

Brucelose

ORPHA:1304 · MONDO:0005683
Prevalência
<1 / 1 000 000
Herança
Not applicable
CID-10
A23.3 · Brucelose por Brucella canis
CID-11
Ensaios
2 ativos
Início
All ages
Prevalência
0.09 (Europe)
MedGen
UMLS
C0006309
Repurposing
2 candidatos
demeclocyclinebacterial 30S ribosomal subunit inhibitor
minocycline
EuropePMC
Wikidata
Wikipedia
Papers 10a
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