A febre hemorrágica da Crimeia-Congo (CCHF) é uma doença zoonótica transmitida por carrapatos causada pelo vírus CCHF e caracterizada por febre inicial, dor de cabeça e mal-estar seguido de sintomas gastrointestinais e, em casos graves, sangramento, choque e falência de múltiplos órgãos.
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A febre hemorrágica da Crimeia-Congo (CCHF) é uma doença zoonótica transmitida por carrapatos causada pelo vírus CCHF e caracterizada por febre inicial, dor de cabeça e mal-estar seguido de sintomas gastrointestinais e, em casos graves, sangramento, choque e falência de múltiplos órgãos.
Escala de raridade
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1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.198
Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.
Crimean-Congo hemorrhagic fever (CCHF) is a viral disease with a fatality rate up to 40%, transmitted through tick bites and infected livestock. Afghanistan's livestock farming and limited public health infrastructure increase infection risks. This study assesses butchers' awareness, attitudes, and practices regarding CCHF in Kabul to identify gaps and inform targeted interventions. A cross-sectional study was conducted among butchers in Kabul from August to September 2024 using cluster sampling. Data from 179 butchers across four districts were collected via questionnaires and analyzed with SPSS version 27. The response rate exceeded 95%. Participants averaged 37 ± 13 years, with 31.8% having over 20 years of experience. Mean scores were 27.7 ± 3.8/38 for awareness, 18.4 ± 2.3/25 for attitudes, and 10.9 ± 2.3/16 for practices. While 41.9% showed good awareness and 61.5% had positive attitudes, only 42.5% demonstrated good practices. Significant misconceptions included belief in waterborne (52.5%) and airborne (31.8%) transmission. Unsafe practices like holding knives in the mouth (4.5%) and inconsistent protective equipment use were observed. A moderate positive correlation existed between attitudes and practices (r = 0.433, p < 0.001). A substantial gap exists between butchers' knowledge and practices regarding CCHF. Targeted educational interventions addressing attitudes and practical barriers are essential to improve safety practices.
Correction: Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.
[This corrects the article DOI: 10.1371/journal.pone.0320495.].
Active transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).
This study is a retrospective and descriptive cross-sectional analysis examining demographic and epidemiological data of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Iraq, covering confirmed cases from January 2018 to December 2023. Utilizing data from the Iraq CDC/zoonotic department, 1001 cases were analyzed and confirmed via Real-time PCR and ELISA tests at the Central Public Health Laboratory. The study highlights the climatic conditions of Iraq, with its semi-arid and semi-tropical climate influencing disease prevalence. Results indicate a significant gender disparity in CCHFV cases, with 59.4 % male and 40.6 % female patients, suggesting differing exposure and susceptibility between genders. The age distribution shows higher infection rates among individuals aged 22 to 51, potentially linked to occupational exposure and outdoor activities. A notable increase in reported cases was observed in 2022 and 2023, accounting for 38.0 % and 58.6 % of total cases, respectively. This surge may be attributed to environmental and socio-economic factors, including climate change, urbanization, and population displacement. Geographic analysis reveals that provinces like Thiqar, Baghdad, Basra, and Misan report higher case numbers, indicating regional hotspots for CCHFV transmission. Risk factor analysis emphasizes the role of direct contact with raw meat, animal slaughtering, and tick bites as significant contributors to infection. The study also identifies key symptoms associated with poor prognosis, such as bleeding from injection sites, body orifices, and echymosis, which are significantly correlated with higher mortality rates. These findings underscore the need for targeted public health interventions, including enhanced surveillance, vector control, and public education, particularly in high-risk regions. Understanding the epidemiology and risk factors of CCHFV is crucial for developing effective prevention and control strategies to mitigate the impact of this disease in Iraq.
Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.
Iwanai Valley virus (IWVV) is a novel tick-borne orthonairovirus classified into the Tamdy genogroup. Since several orthonairoviruses in the Tamdy and closely related Sulina genogroups have been associated with human diseases, evaluating the pathogenic potential of IWVV is an important public health priority. Despite the increase in reports of orthonairoviruses belonging to the Tamdy and Sulina genogroups in East Asia, studies on their pathogenicity remain limited. In this study, we established a mouse model of IWVV infection using type I interferon receptor knockout (IFNAR1-/-) mice and analyzed the pathogenicity of IWVV infection. IWVV infection was lethal in IFNAR1-/-mice but did not cause any significant symptoms in BALB/c mice. IWVV replicated well in the liver and spleen of IFNAR1-/-mice, leading to acute necrotizing hepatitis and damage to the spleen, characterized by lymphocyte depletion. These pathological features are consistent with those observed in immunocompromised mice infected with other human-pathogenic orthonairoviruses, such as Crimean-Congo hemorrhagic fever virus and Yezo virus. Although human infections with IWVV have not been reported, the observed virulence in animal models suggests that further evaluation of its zoonotic potential is warranted. Our findings highlight the importance of continued surveillance of emerging tick-borne IWVV to assess potential risks to public health.
Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.
Crimean-Congo hemorrhagic fever (CCHF) is a life-threatening viral infection with multiorgan involvement. While laboratory markers are well-established, the prognostic value of ultrasonography (US) remains underexplored. This prospective study aimed to characterize abdominal US findings in patients with suspected CCHF and to assess their correlation with clinical parameters and disease severity. A total of 122 patients hospitalized with suspected CCHF were included and classified as RT-PCR positive (n = 70) and RT-PCR negative control (n = 52) groups. Serial abdominal US was performed on days 1, 3, and 5 of hospitalization. Sonographic findings, clinical data, and Severity Scoring Index (SSI) values were recorded and analyzed. The most frequent sonographic findings in RT-PCR-positive patients were hepatomegaly (30%), gallbladder wall thickening (26%), periportal echogenicity (19%) and intra-abdominal free fluid (19%). Notably, gallbladder wall thickening was significantly more common in the patient group compared with controls (p = 0.034), while splenomegaly was significantly more frequent in the RT-PCR-negative group (p = 0.003). US findings showed significant regression by day 5, paralleling SSI improvement (p < 0.001). Abdominal US serves as a complementary, non-invasive modality in the clinical evaluation and follow-up of patients with suspected CCHF. The correlation between US findings and SSI scores, together with the temporal evolution of sonographic changes, highlights its potential to be incorporated into future disease severity scoring systems as a non-invasive prognostic indicator. Routine use of abdominal US, particularly in endemic regions, may provide meaningful support in the early detection of complications, dynamic assessment of disease severity, and objective monitoring of treatment response, thereby enhancing clinical decision-making.
Publicações recentes
Detection and genetic characterization of Crimean-Congo hemorrhagic fever virus in ticks from western Spain (2017, 2020-2024).
Systematic review and meta-analysis for the occurrence of Crimean-Congo hemorrhagic fever, Tularemia, and Rift Valley fever in pastoralist systems in Africa.
One Health Living Lab: A Collaborative and Novel Approach to Zoonotic Public Health Challenges in Portugal.
ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction.
Prognostic Value of Admission Glucose and Extended Lipid Profile in Patients with Crimean-Congo Hemorrhagic Fever.
📚 EuropePMC1.393 artigos no totalmostrando 196
Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.
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Frontiers in immunologyCCHFV Seroprevalence among Hunter-Gatherers, Northeastern Democratic Republic of the Congo.
Emerging infectious diseasesImmunoreactivity of pan MHC-I epitopes on Crimean-Congo hemorrhagic fever virus glycoprotein C-terminal.
Frontiers in immunologyAccuracy of rapid and near-patient diagnostics for detection of rift valley fever and Crimean-Congo haemorrhagic Fever infections: A systematic review and meta-analysis.
Diagnostic microbiology and infectious diseaseBridging the gap: ex vivo human skin explants for mechanistic studies of arboviruses.
Current opinion in virologyThe contribution of viral toxins to infection and pathogenesis.
mBioPrognostic accuracy of severity grading score and severity scoring index for predicting severe outcomes in Crimean-Congo hemorrhagic fever: a systematic review and meta-analysis.
InfectionHost Community Traits Driving Crimean-Congo Hemorrhagic Fever Virus Maintenance in Iberian Ecosystems.
Transboundary and emerging diseasesAssessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.
Health science reportsCRISPR-Based Detection of Viral Hemorrhagic Fevers at the Point of Care.
VirusesMicrobiological perspectives on Crimean-Congo hemorrhagic fever: Seroprevalence and viral pathogenesis in Iraq.
Biotechnology notes (Amsterdam, Netherlands)Prognostic value of sCD163, IL-6, PLR, and SII in predicting disease severity in Crimean-Congo hemorrhagic fever: a prospective study.
Pathogens and global healthRepurposing Cilnidipine as an entry inhibitor against Crimean-Congo Hemorrhagic Fever pseudovirus infection.
Archives of virologyMachine learning-based mortality prediction models for Crimean-Congo hemorrhagic fever patients.
Journal of vector borne diseasesSeasonal patterns of Crimean-Congo hemorrhagic fever in Afghanistan: environmental factors and public health implications, 2022-2024.
International journal of environmental health researchDifferences in cynomolgus macaque populations used for infectious disease research.
Animal models and experimental medicineDevelopment and Characterization of Microsatellite Genetic Markers for Hyalomma rufipes, a Tick Vector of Crimean-Congo Hemorrhagic Fever Virus.
Ecology and evolutionGP38 is a structural component of Crimean-Congo hemorrhagic fever virus particles.
Virologica SinicaAmino Terminal Region of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Nucleocapsid (NP) Protein Contains Dominant Epitopes Recognised by Cellular Immunity.
ImmunologyHigh Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever Virus in Camels at Livestock Markets in Border Regions, Nigeria, 2023-2024.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Crimean-congo hemorrhagic fever in Iraq, 2021-2024: epidemiological and clinical data analysis with proposed severity indicators for resource-constrained settings.
BMC infectious diseasesTargeted organic acid profiling in Crimean-Congo hemorrhagic fever: A metabolomics-based approach to biomarker discovery.
Antiviral researchFirst Detection of Jingmen Tick Virus in Hard Ticks Collected Across Multiple Regions of Italy.
VirusesThe Outcome of PCR Versus IGM Timing Study in the Diagnosis of the Crimean-Congo Hemorrhagic Fever Outbreak in Iraq during 2021-2022.
Pharmaceutical nanotechnologyFrom pandemic influenza to novel coronaviruses: emerging infectious diseases of the 21st century.
Diagnostic microbiology and infectious diseaseNew markers predicting prognosis in patients with Crimean-Congo hemorrhagic fever: HDL cholesterol and eosinophil levels.
Pathogens and global healthHospital preparedness and operational adaptation for the safe management of Crimean-Congo haemorrhagic fever patients.
The Journal of hospital infectionField vaccination against CCHFV and Hyalomma tick infestation reduces multiple tick-borne infections in sheep.
NPJ vaccinesIn Silico Analysis of Potential Vaccine Antigens for the Treatment of Crimean-Congo Hemorrhagic Fever Virus (Cchfv).
Pharmaceutical researchIdentification and classification of Crimean-Congo hemorrhagic fever virus from Hyalomma asiaticum from southern Mongolia.
Ticks and tick-borne diseasesCrimean-Congo hemorrhagic fever: serum neopterin levels and their relationship with clinical course.
Revista da Associacao Medica Brasileira (1992)Structure and function of the nairovirus cap-snatching endonuclease.
Nucleic acids researchIdentification of claramine and anidulafungin as entry inhibitors of Crimean-Congo hemorrhagic fever virus.
Antiviral researchDiscrimination of Hard Ticks by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
International journal of molecular sciencesInhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.
NAR molecular medicineThermodynamic Analysis of the Stability of the Crimean-Congo Hemorrhagic Fever Virus on Inanimate Surfaces.
Journal of medical virologyA Compendium Review of the Global Epidemiology of Ticks and Tick-borne Diseases: Regional Insights from Türkiye.
Turkiye parazitolojii dergisiA multisectoral effort against Crimean-Congo hemorrhagic fever: Towards One Health approach implementation in the Balkans and Black Sea region.
One health (Amsterdam, Netherlands)Co-Circulation of Tick-Borne Bandaviruses and Orthonairoviruses Across Humans, Livestock, and Rats in Pakistan: Serologic Evidence and Public Health Implications.
VirusesSeroprevalence of Crimean-Congo Hemorrhagic Fever and Rift Valley Fever Viruses Among Ruminants in Nigeria: A Descriptive Epizootiological Analysis.
Pathogens (Basel, Switzerland)Serologic Evidence of Circulation of Six Arboviruses (Dengue Virus, Chikungunya Virus, Zika Virus, Rift Valley Virus, Yellow Fever Virus, Crimean-Congo Hemorrhagic Fever Virus) in Four Regions of Burkina Faso, West Africa.
Tropical medicine and infectious diseaseTransforming One Health in India: National Multisectoral Mixed Method Study on Prioritization of Zoonotic Diseases.
JMIR public health and surveillanceActive transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).
Research in veterinary scienceAn Overview of the Crimean-Congo Hemorrhagic Fever Outbreak in Iraq.
Open forum infectious diseasesSpatiotemporal and clinical dynamics of Crimean-Congo Hemorrhagic Fever in Wasit Governorate, Iraq (2022-2025): a retrospective analytical study.
BMC infectious diseasesCrimean-Congo hemorrhagic fever: An emerging threat in Europe.
Virologica SinicaDetection of Crimean-Congo hemorrhagic fever virus and Rift Valley fever virus antibodies in animal workers in Cameroon.
Frontiers in veterinary sciencePathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.
The Journal of veterinary medical scienceThe first detection of Jingmen tick virus (JMTV) in humans in Türkiye, 2022.
Pathogens and global healthA single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection.
NPJ vaccinesCrimean-Congo Hemorrhagic Fever Virus in Cattle and Ticks, Israel.
Emerging infectious diseasesElectrochemical immunosensor for sensitive detection of Crimean-Congo hemorrhagic fever virus based on a flexible electrode of carbon nanofibers modified with copper (II) phosphate nanoflowers.
Biosensors & bioelectronicsComparison of Blood Parameters in Crimean-Congo Hemorrhagic Fever and Upper Respiratory Infection Patients with Similar Complaints.
Iranian journal of public healthNeutralization of Crimean-Congo hemorrhagic fever pseudotyped virions with heavy chain antibodies.
Virologica SinicaSeroprevalence of four zoonotic viral diseases in camels in Qatar.
Journal of infection and public healthThe risk of human- and mammal-infecting tick-borne viruses in northwest China and adjacent countries.
Nature communicationsCrimean-Congo hemorrhagic fever virus localization and shedding in the reproductive tract of lethal and survivor mouse models.
Emerging microbes & infectionsChemical composition and acaricidal properties of essential oils from Cinnamomum mollifolium, Eucalyptus globulus, and Pimenta dioica against Hyalomma rufipes (Acari: Ixodidae).
BMC veterinary researchOral VV261 administration protects mice from lethal Crimean-Congo hemorrhagic fever virus challenge.
Journal of virologyGenBank2PubMed: bridging viral genomic data and the scientific literature with AI-assisted curation.
Scientific reportsRNA virome of ticks and fleas infesting Marmota himalayana from the Qinghai-Tibet plateau.
Animal microbiomeDurable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice.
NPJ vaccinesDiversity, distribution, and climate change impacts on tick fauna in Saudi Arabia: A comprehensive ecological niche modeling approach.
Microbial pathogenesisGenetic features of Orthonairovirus haemorrhagiae variants detected in ixodid ticks in Armenia.
PLoS neglected tropical diseasesDescriptive Epidemiology of Acute Febrile Illness Patients in Nigeria: Pathogens of Global Public Health Significance Detected Using a Multi-Pathogen Detection Tool.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaBrucellosis Seroprevalence and Diagnostic Challenges: A Comprehensive Review from 2017-2021.
Journal of clinical practice and researchPathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4'-fluorouridine therapy.
Journal of virologyEpidemiology of the Crimean-Congo hemorrhagic fever virus.
Acta tropicaViral hemorrhagic fevers - therapeutic trial advances and challenges.
Expert review of anti-infective therapySerosurveillance of Crimean-Congo hemorrhagic fever virus in zoo animals, Spain, 2007-2024.
Veterinary microbiologyDesign, synthesis and preliminary biological evaluation of novel carbamoyl pyridone derivatives as potent inhibitors of Crimean-Congo hemorrhagic fever virus.
European journal of medicinal chemistryPhenotypic and genetic changes of Crimean-Congo hemorrhagic fever virus during serial passage in susceptible cell lines.
Archives of virologyCrimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2.
PLoS neglected tropical diseasesAbdominal computed tomography findings in Crimean-Congo hemorrhagic fever: correlations with disease severity and prognostic implications.
Abdominal radiology (New York)[Spinal Epidural Abscess and Spondylodiscitis Following Crimean-Congo Hemorrhagic Fever: A Rare Post-Recovery Complication].
Mikrobiyoloji bulteniAcute Hepatic Failure in Crimean-Congo Hemorrhagic Fever: A Case Report.
Clinical case reportsFirst Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus Infections in Croatia: A Multispecies Surveillance Approach Emphasising the Role of Sentinel Hosts.
VirusesPrognostic Significance of CRP/Albumin, D-Dimer/Albumin, D-Dimer/Fibrinogen Ratios and Triglyceride-Glucose Index in Crimean-Congo Hemorrhagic Fever: A Prospective Observational Study.
Tropical medicine and infectious diseaseSerologic evidence of crimean-congo hemorrhagic fever virus exposure among livestock and farmers in the Democratic Republic of the Congo.
PLoS neglected tropical diseasesGenetic evidence of regional circulation of Crimean-Congo hemorrhagic fever virus in ixodid ticks from southern Kazakhstan.
Frontiers in veterinary scienceCrimean-Congo Hemorrhagic Fever Disease: Relationship Between Clinical Course and Apoptosis.
Infectious diseases & clinical microbiologyComparative evaluation of a multiplex polymerase chain reaction panel for high-consequence infectious diseases against conventional diagnostics in travelers with febrile diseases.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesA non-fatal Crimean-Congo hemorrhagic fever virus infection; The balanced cytokine responses on the outcome of the clinical disease.
Diagnostic microbiology and infectious diseaseTracking invasion events: phylogeography of Hyalomma marginatum in the Mediterranean basin with a focus on Southern France.
Parasites & vectorsEvidence of Crimean-Congo hemorrhagic fever (CCHF) susceptibility among big felids in Namibia: leopards (Panthera pardus) and lions (Panthera leo).
Veterinaria italianaStriking tick-borne virus diversity and potential reservoirs documented during One-Health-based cross-sectional screening in Anatolia.
Parasites & vectorsA fatal case of Herpes simplex virus-2 infection imported from Sharjah to India: Need for differential diagnosis amid Mpox surveillance.
Diagnostic microbiology and infectious diseaseGenetic Diversification of Crimean-Congo Hemorrhagic Fever Virus Lineage Europe 1.
Annals of the New York Academy of SciencesCrimean-Congo Hemorrhagic Fever Virus Circulation in Wild European Rabbits, Portugal, 2018-2023.
Emerging infectious diseasesMulticriteria Decision Analysis as a Tool for Assessing Vector-Borne Diseases Risk: The Case of Crimean-Congo Hemorrhagic Fever in Türkiye.
MicroorganismsThe first finding of Hyalomma rufipes in Poland in 2024: the promising start of a citizen science project.
Parasites & vectorsFirst detection of Crimean Congo Hemorrhagic Fever antibodies in cattle and wildlife of southern continental France: Investigation of explanatory factors.
PloS oneCrimean-Congo hemorrhagic fever virus Africa 1 lineage in Hyalomma species ticks, Tunisia, 2024.
Journal of virologySilent killer strikes during Eid-Ul-Adha: Crimean-Congo hemorrhagic fever outbreak in Khyber Pakhtunkhwa, Pakistan, 2023.
Journal of infection and public healthDevelopment of a Rapid Diagnostic Test to Distinguish between Emerging Viruses That Cause Hemorrhagic Fever.
The American journal of tropical medicine and hygieneAn orally available 4'-fluorouridine prodrug inhibits SFTSV and LCMV infection.
Journal of virologyEvaluation of Clinical and Hematological Findings of Pediatric Patients with Crimean-Congo Hemorrhagic Fever.
Klinische PadiatrieCCHFV-M based DNA vaccine is highly immunogenic in multiple species and protects against challenge in cynomolgus macaques.
Antiviral researchCrimean-Congo Hemorrhagic Fever Accompanied by Acalculous Cholecystitis and Pancytopenia: A Rare Case.
Turkish journal of haematology : official journal of Turkish Society of HaematologyThe first reported Crimean-Congo hemorrhagic fever reinfection in the literature: 11 years apart.
Diagnostic microbiology and infectious diseaseIdentification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses.
VirusesMolecular Evolution and Phylogeography of the Crimean-Congo Hemorrhagic Fever Virus.
VirusesMolecular and Clinical Characterization of Crimean-Congo Hemorrhagic Fever in Bulgaria, 2015-2024.
Pathogens (Basel, Switzerland)Tick-Borne Pathogens in Companion Animals and Zoonotic Risk in Portugal: A One Health Surveillance Approach.
MicroorganismsIdentification of Hyalomma Ticks on Migratory Birds in Poland During the 2023 and 2024 Spring Seasons.
Life (Basel, Switzerland)Decoding blood fatty acids in Crimean-Congo hemorrhagic fever.
Metabolomics : Official journal of the Metabolomic SocietySoluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus.
mBioStability of the Crimean-Congo Hemorrhagic Fever Virus on Inanimate Surfaces and Implications for Infection Control.
Journal of medical virologyEpigenetic modulation of ALKBH5, FTO and YTHDF2 genes in crimean-congo haemorrhagic fever patients depending on RNA methylation.
Molecular biology reportsRelationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever.
Revista da Associacao Medica Brasileira (1992)Genetic Variations in Crimean-Congo Hemorrhagic Fever Virus: Challenges for Molecular Diagnostic Assays-A Case Report.
Case reports in infectious diseasessVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.
EMBO reportsHyalomma marginatum in Europe: The Past, Current Status, and Future Challenges-A Systematic Review.
Transboundary and emerging diseasesDrivers of Crimean-Congo Hemorrhagic Fever in Natural Host and Effects of Control Measures, Bulgaria.
Emerging infectious diseasesZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein.
The Journal of biological chemistryHighly sensitive and multiplex detection of nine potential bioterrorism viral agents in a single reaction by multiplex probe amplification (MPA) with melting curve analysis.
Microbiology spectrumChest computed tomography assessment of patients with crimean- congo hemorrhagic fever: a comparison between survivors and nonsurvivors.
Journal of vector borne diseasesHarnessing Hazara Virus as a Surrogate for Crimean-Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level.
Pathogens (Basel, Switzerland)Tick-Borne Viruses in a Changing Climate: The Expanding Threat in Africa and Beyond.
MicroorganismsIn-silico study: Hm86 protein of Hyalomma marginatum (Ixodida) as a candidate to provide anti-tick vaccine.
Scientific reportsRapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies.
EBioMedicineSeroprevalence of Rift Valley and Crimean-Congo Hemorrhagic Fever Viruses, Benin, 2022-2023.
Emerging infectious diseasesCrimean-Congo Hemorrhagic Fever Virus among Goats, Southern Bhutan.
Emerging infectious diseasesCrimean-Congo Hemorrhagic Fever Virus Africa 1 Lineage in Hyalomma dromedarii Ticks, Algeria, 2023.
Emerging infectious diseasesA comprehensive review on the epidemiology of arboviruses in the Eastern Mediterranean Region (EMRO): insights from the WHO's Regional Office.
GMS hygiene and infection controlA Case of Crimean-Congo Hemorrhagic Fever Presenting to the Emergency Department with Postmenopausal Vaginal Bleeding.
The Journal of emergency medicineEvidence of Crimean-Congo hemorrhagic fever virus in livestock and wildlife in Northeastern Portugal.
Scientific reportsCrimean-Congo Hemorrhagic Fever Outbreak in Podor, Northern Senegal in 2022: Two Independent Emergences and Unprecedented Mortality.
The American journal of tropical medicine and hygieneTick-Borne Infectious Diseases in China, 2003-2023.
China CDC weeklyRapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda.
BMC infectious diseasesSeroprevalence and factors associated with CCHF virus infection in cattle and sheep in Mopti region (Mali).
Archives of Razi InstituteInsights into Crimean-Congo hemorrhagic fever virus exposure probability: a period cross-sectional study in wild and domestic ungulates.
Journal of medical entomologyFirst report of Crimean-Congo hemorrhagic fever virus exposure in human and livestock populations, Center Region, Cameroon.
Frontiers in cellular and infection microbiologyThe Single Amino Acid Change of R516K Enables Efficient Generation of Vesicular Stomatitis Virus-Based Crimean-Congo Hemorrhagic Fever Reporter Virus.
Journal of medical virologySeroprevalence study for selected zoonotic vector-borne pathogens in sheep from endemic areas of Croatia.
Frontiers in veterinary scienceNMR side-chain assignments of the Crimean-Congo hemorrhagic fever virus glycoprotein n cytosolic domain.
Magnetic resonance (Gottingen, Germany)Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing.
Journal of virologyHuman tick biting and tick-borne disease risk in Türkiye: Systematic review.
PLoS neglected tropical diseasesFactors associated with knowledge, attitudes, and practices of mixed crop-livestock farmers on Crimean-Congo hemorrhagic fever (CCHF) and other zoonoses in Burkina Faso.
One health (Amsterdam, Netherlands)Serosurveillance of Crimean-Congo hemorrhagic fever virus antibodies in livestock as a reservoir for human infection in Afghanistan.
One health (Amsterdam, Netherlands)Fatal Crimean-Congo Hemorrhagic Fever with an Atypical Clinical Course during the COVID-19 Pandemic.
Journal of arthropod-borne diseasesDetecting spatial clusters of Crimean Congo hemorrhagic fever in Iraq in 2023.
Global epidemiologyTreatment and management of Crimean-Congo hemorrhagic fever.
Journal of vector borne diseasesZoonotic arbovirus infections in cattle in Mozambique with special reference to Crimean-Congo hemorrhagic fever virus (CCHFV) and rift valley fever virus (RVFV).
Virology journalExploring approaches and advancements in the development and evaluation of multi-epitope subunit vaccines against tick-borne viruses.
Veterinary microbiologyCrimean-Congo hemorrhagic fever with severe bradycardia treated with Theophylline.
Revista da Sociedade Brasileira de Medicina TropicalSingle dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge.
NPJ vaccinesSuccessful Inactivation of High-Consequence Pathogens in PrimeStore Molecular Transport Media.
VirusesPersistent Infections in Tick Cell Lines: The Role of Viral-Derived DNA Forms in Hazara Virus Replication and Cellular Survival.
VirusesAssociation Between IL-28B (rs8099917) and IL-28B (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis.
Pathogens (Basel, Switzerland)Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc.
Virologica SinicaSemi-automated diagnostic RT-PCR as a screening assay for antiviral compounds in a 96-well format against highly pathogenic RNA viruses.
Advances in virus researchCrimean-Congo Hemorrhagic Fever Virus Infections in Slaughtered Camels and Abattoir Workers in the United Arab Emirates.
Transboundary and emerging diseasesMucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine.
Cell researchDeaths in animal attacks: A 10-year retrospective forensic analysis of direct and indirect causes.
Journal of forensic sciencesSpatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.
PloS oneRe-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case.
One health (Amsterdam, Netherlands)The nucleocapsid protein of Crimean-Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cells.
The Journal of biological chemistryA mouse model of Crimean-Congo hemorrhagic fever virus-induced coagulopathy.
Virologica SinicaOutbreak of Crimean-Congo hemorrhagic fever in Kyzylorda region, Kazakhstan, March-July 2022.
Frontiers in public healthCO-OCCURRENCE OF HANTAVIRUS PULMONARY SYNDROME AND HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Georgian medical newsExposure to Crimean-Congo Hemorrhagic Fever Virus in Wild Ungulates in the Basque Country, Northern Iberian Peninsula.
Transboundary and emerging diseasesEvaluation of a Luminex-Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal.
Transboundary and emerging diseasesHost genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.
Npj virusesPrognostic Value of Ratios of Inflammatory Markers in the Prognosis of Crimean-Congo Hemorrhagic Fever.
Tropical medicine and infectious diseaseThe Growing Threat of Tick-Borne Viruses: Global Trends, Clinical Outcomes, and Diagnostic Strategies.
Viral immunologyPrime-Boost Vaccination Based on Nanospheres and MVA Encoding the Nucleoprotein of Crimean-Congo Hemorrhagic Fever Virus Elicits Broad Immune Responses.
VaccinesA case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.
Journal of neurovirologyMechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis.
Antiviral researchAvidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.
mBioSerological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France).
One health (Amsterdam, Netherlands)A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.
EBioMedicinePrevalence Rates and Outcomes of Hyponatremia in Patients with Crimean-Congo Hemorrhagic Fever.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Development of FRET-based cap-snatching endonuclease assay.
Microbiology spectrumSeroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever Exposure in Wild and Domestic Animals in Benin.
VirusesCrimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges.
World journal of virologyAuthor Correction: Spatial analysis and risk mapping of Crimean-Congo hemorrhagic fever (CCHF) in Sub-Saharan Africa.
Scientific reportsMapping the potential suitable habitats for Hyalomma rufipes (Acari: Ixodidae) in Africa and Western Eurasia.
PLoS neglected tropical diseasesDrug repositioning as a promising approach for the eradication of emerging and re-emerging viral agents.
Molecular diversityPredictive role of non-viral leukocyte parameters in tracking the development and progression of Crimean-Congo hemorrhagic fever.
Microbial pathogenesisKaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.
Antiviral research[Specific precautions against Crimean-Congo hemorrhagic fever in patients with general symptoms after a tick bite].
Gaceta sanitariaMolecular characterization and phylogenetic analysis of Crimean-Congo hemorrhagic fever virus, northwestern of Iran.
BMC infectious diseasesCrimean-Congo hemorrhagic fever, a real health problem in Iraq?
IJID regionsEmerging Arboviral Diseases in Pakistan: Epidemiology and Public Health Implications.
VirusesCrimean-Congo Hemorrhagic Fever Mimicking HELLP Syndrome in a Pregnant Woman and Her Infant in Kosovo: A Case Report.
VirusesCrimean-Congo hemorrhagic fever: Strategies for diagnosis at initial admission.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesTwo Human Infections with Diverse Europe-1 Crimean-Congo Hemorrhagic Fever Virus Strains, North Macedonia, 2024.
Emerging infectious diseasesAntibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread.
Science translational medicineEffectiveness of nucleoside analogs against Wetland virus infection.
Antiviral researchLongitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda.
Emerging microbes & infectionsElucidating Infectious Causes of Fever of Unknown Origin: A Laboratory-Based Observational Study of Patients with Suspected Ebola Virus Disease, Guinea, 2014.
The Journal of infectious diseasesIdentification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.
Bioorganic & medicinal chemistryHidden threats: Brucellosis diagnosis and co-infection patterns in Crimean-Congo Hemorrhagic Fever suspects.
Diagnostic microbiology and infectious diseaseLift-CM: An integrated lift-heater centrifugal microfluidic platform for point-of-care pathogen nucleic acid detection using isothermal amplification and CRISPR/Cas12a.
Biosensors & bioelectronicsAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Comunidades
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.
- Correction: Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.
- Active transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).
- Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.
- Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.
- Detection and genetic characterization of Crimean-Congo hemorrhagic fever virus in ticks from western Spain (2017, 2020-2024).
- Systematic review and meta-analysis for the occurrence of Crimean-Congo hemorrhagic fever, Tularemia, and Rift Valley fever in pastoralist systems in Africa.
- One Health Living Lab: A Collaborative and Novel Approach to Zoonotic Public Health Challenges in Portugal.
- ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction.
- Prognostic Value of Admission Glucose and Extended Lipid Profile in Patients with Crimean-Congo Hemorrhagic Fever.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:99827(Orphanet)
- MONDO:0020501(MONDO)
- GARD:19690(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1077505(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
