Raras
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Febre hemorrágica Crimeia-Congo (CCHF)
ORPHA:99827CID-10 · A98.0CID-11 · 1D49DOENÇA RARA

A febre hemorrágica da Crimeia-Congo (CCHF) é uma doença zoonótica transmitida por carrapatos causada pelo vírus CCHF e caracterizada por febre inicial, dor de cabeça e mal-estar seguido de sintomas gastrointestinais e, em casos graves, sangramento, choque e falência de múltiplos órgãos.

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Introdução

O que você precisa saber de cara

📋

A febre hemorrágica da Crimeia-Congo (CCHF) é uma doença zoonótica transmitida por carrapatos causada pelo vírus CCHF e caracterizada por febre inicial, dor de cabeça e mal-estar seguido de sintomas gastrointestinais e, em casos graves, sangramento, choque e falência de múltiplos órgãos.

Pesquisas ativas
4 ensaios
9 total registrados no ClinicalTrials.gov
Publicações científicas
1.818 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A98.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
10 sintomas
🫃
Digestivo
7 sintomas
❤️
Coração
5 sintomas
👁️
Olhos
4 sintomas
🫘
Rins
3 sintomas
📏
Crescimento
1 sintomas

+ 47 sintomas em outras categorias

Características mais comuns

90%prev.
Extravasamento capilar
Muito frequente (99-80%)
90%prev.
Febre
Muito frequente (99-80%)
90%prev.
Aumento do nível circulante de IgM
Muito frequente (99-80%)
90%prev.
Trombocitopenia
Muito frequente (99-80%)
55%prev.
Anorexia
Frequente (79-30%)
55%prev.
Epistaxe
Frequente (79-30%)
80sintomas
Muito frequente (4)
Frequente (17)
Ocasional (30)
Muito raro (27)
Sem dados (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 80 características clínicas mais associadas, ordenadas por frequência.

Extravasamento capilarCapillary leak
Muito frequente (99-80%)90%
FebreFever
Muito frequente (99-80%)90%
Aumento do nível circulante de IgMIncreased circulating IgM level
Muito frequente (99-80%)90%
TrombocitopeniaThrombocytopenia
Muito frequente (99-80%)90%
Anorexia
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.818PubMed
Últimos 10 anos200publicações
Pico2025146 papers
Linha do tempo
2026Hoje · 2026🧪 2009Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 22
1Fase 13
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 7 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Febre hemorrágica Crimeia-Congo (CCHF)

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

9 ensaios clínicos encontrados, 4 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.198 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.198

#1

Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.

Health science reports2026 Mar

Crimean-Congo hemorrhagic fever (CCHF) is a viral disease with a fatality rate up to 40%, transmitted through tick bites and infected livestock. Afghanistan's livestock farming and limited public health infrastructure increase infection risks. This study assesses butchers' awareness, attitudes, and practices regarding CCHF in Kabul to identify gaps and inform targeted interventions. A cross-sectional study was conducted among butchers in Kabul from August to September 2024 using cluster sampling. Data from 179 butchers across four districts were collected via questionnaires and analyzed with SPSS version 27. The response rate exceeded 95%. Participants averaged 37 ± 13 years, with 31.8% having over 20 years of experience. Mean scores were 27.7 ± 3.8/38 for awareness, 18.4 ± 2.3/25 for attitudes, and 10.9 ± 2.3/16 for practices. While 41.9% showed good awareness and 61.5% had positive attitudes, only 42.5% demonstrated good practices. Significant misconceptions included belief in waterborne (52.5%) and airborne (31.8%) transmission. Unsafe practices like holding knives in the mouth (4.5%) and inconsistent protective equipment use were observed. A moderate positive correlation existed between attitudes and practices (r = 0.433, p < 0.001). A substantial gap exists between butchers' knowledge and practices regarding CCHF. Targeted educational interventions addressing attitudes and practical barriers are essential to improve safety practices.

#2

Correction: Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.

PloS one2026

[This corrects the article DOI: 10.1371/journal.pone.0320495.].

#3

Active transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).

Research in veterinary science2026 Mar

This study is a retrospective and descriptive cross-sectional analysis examining demographic and epidemiological data of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Iraq, covering confirmed cases from January 2018 to December 2023. Utilizing data from the Iraq CDC/zoonotic department, 1001 cases were analyzed and confirmed via Real-time PCR and ELISA tests at the Central Public Health Laboratory. The study highlights the climatic conditions of Iraq, with its semi-arid and semi-tropical climate influencing disease prevalence. Results indicate a significant gender disparity in CCHFV cases, with 59.4 % male and 40.6 % female patients, suggesting differing exposure and susceptibility between genders. The age distribution shows higher infection rates among individuals aged 22 to 51, potentially linked to occupational exposure and outdoor activities. A notable increase in reported cases was observed in 2022 and 2023, accounting for 38.0 % and 58.6 % of total cases, respectively. This surge may be attributed to environmental and socio-economic factors, including climate change, urbanization, and population displacement. Geographic analysis reveals that provinces like Thiqar, Baghdad, Basra, and Misan report higher case numbers, indicating regional hotspots for CCHFV transmission. Risk factor analysis emphasizes the role of direct contact with raw meat, animal slaughtering, and tick bites as significant contributors to infection. The study also identifies key symptoms associated with poor prognosis, such as bleeding from injection sites, body orifices, and echymosis, which are significantly correlated with higher mortality rates. These findings underscore the need for targeted public health interventions, including enhanced surveillance, vector control, and public education, particularly in high-risk regions. Understanding the epidemiology and risk factors of CCHFV is crucial for developing effective prevention and control strategies to mitigate the impact of this disease in Iraq.

#4

Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.

The Journal of veterinary medical science2026 Feb 01

Iwanai Valley virus (IWVV) is a novel tick-borne orthonairovirus classified into the Tamdy genogroup. Since several orthonairoviruses in the Tamdy and closely related Sulina genogroups have been associated with human diseases, evaluating the pathogenic potential of IWVV is an important public health priority. Despite the increase in reports of orthonairoviruses belonging to the Tamdy and Sulina genogroups in East Asia, studies on their pathogenicity remain limited. In this study, we established a mouse model of IWVV infection using type I interferon receptor knockout (IFNAR1-/-) mice and analyzed the pathogenicity of IWVV infection. IWVV infection was lethal in IFNAR1-/-mice but did not cause any significant symptoms in BALB/c mice. IWVV replicated well in the liver and spleen of IFNAR1-/-mice, leading to acute necrotizing hepatitis and damage to the spleen, characterized by lymphocyte depletion. These pathological features are consistent with those observed in immunocompromised mice infected with other human-pathogenic orthonairoviruses, such as Crimean-Congo hemorrhagic fever virus and Yezo virus. Although human infections with IWVV have not been reported, the observed virulence in animal models suggests that further evaluation of its zoonotic potential is warranted. Our findings highlight the importance of continued surveillance of emerging tick-borne IWVV to assess potential risks to public health.

#5

Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.

Vector borne and zoonotic diseases (Larchmont, N.Y.)2026 Apr

Crimean-Congo hemorrhagic fever (CCHF) is a life-threatening viral infection with multiorgan involvement. While laboratory markers are well-established, the prognostic value of ultrasonography (US) remains underexplored. This prospective study aimed to characterize abdominal US findings in patients with suspected CCHF and to assess their correlation with clinical parameters and disease severity. A total of 122 patients hospitalized with suspected CCHF were included and classified as RT-PCR positive (n = 70) and RT-PCR negative control (n = 52) groups. Serial abdominal US was performed on days 1, 3, and 5 of hospitalization. Sonographic findings, clinical data, and Severity Scoring Index (SSI) values were recorded and analyzed. The most frequent sonographic findings in RT-PCR-positive patients were hepatomegaly (30%), gallbladder wall thickening (26%), periportal echogenicity (19%) and intra-abdominal free fluid (19%). Notably, gallbladder wall thickening was significantly more common in the patient group compared with controls (p = 0.034), while splenomegaly was significantly more frequent in the RT-PCR-negative group (p = 0.003). US findings showed significant regression by day 5, paralleling SSI improvement (p < 0.001). Abdominal US serves as a complementary, non-invasive modality in the clinical evaluation and follow-up of patients with suspected CCHF. The correlation between US findings and SSI scores, together with the temporal evolution of sonographic changes, highlights its potential to be incorporated into future disease severity scoring systems as a non-invasive prognostic indicator. Routine use of abdominal US, particularly in endemic regions, may provide meaningful support in the early detection of complications, dynamic assessment of disease severity, and objective monitoring of treatment response, thereby enhancing clinical decision-making.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.393 artigos no totalmostrando 196

2026

Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

Venturing into host-pathogen interaction in Crimean-Congo hemorrhagic fever to highlight terra incognita.

Frontiers in immunology
2026

CCHFV Seroprevalence among Hunter-Gatherers, Northeastern Democratic Republic of the Congo.

Emerging infectious diseases
2026

Immunoreactivity of pan MHC-I epitopes on Crimean-Congo hemorrhagic fever virus glycoprotein C-terminal.

Frontiers in immunology
2026

Accuracy of rapid and near-patient diagnostics for detection of rift valley fever and Crimean-Congo haemorrhagic Fever infections: A systematic review and meta-analysis.

Diagnostic microbiology and infectious disease
2026

Bridging the gap: ex vivo human skin explants for mechanistic studies of arboviruses.

Current opinion in virology
2026

The contribution of viral toxins to infection and pathogenesis.

mBio
2026

Prognostic accuracy of severity grading score and severity scoring index for predicting severe outcomes in Crimean-Congo hemorrhagic fever: a systematic review and meta-analysis.

Infection
2026

Host Community Traits Driving Crimean-Congo Hemorrhagic Fever Virus Maintenance in Iberian Ecosystems.

Transboundary and emerging diseases
2026

Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.

Health science reports
2026

CRISPR-Based Detection of Viral Hemorrhagic Fevers at the Point of Care.

Viruses
2026

Microbiological perspectives on Crimean-Congo hemorrhagic fever: Seroprevalence and viral pathogenesis in Iraq.

Biotechnology notes (Amsterdam, Netherlands)
2026

Prognostic value of sCD163, IL-6, PLR, and SII in predicting disease severity in Crimean-Congo hemorrhagic fever: a prospective study.

Pathogens and global health
2026

Repurposing Cilnidipine as an entry inhibitor against Crimean-Congo Hemorrhagic Fever pseudovirus infection.

Archives of virology
2026

Machine learning-based mortality prediction models for Crimean-Congo hemorrhagic fever patients.

Journal of vector borne diseases
2026

Seasonal patterns of Crimean-Congo hemorrhagic fever in Afghanistan: environmental factors and public health implications, 2022-2024.

International journal of environmental health research
2026

Differences in cynomolgus macaque populations used for infectious disease research.

Animal models and experimental medicine
2026

Development and Characterization of Microsatellite Genetic Markers for Hyalomma rufipes, a Tick Vector of Crimean-Congo Hemorrhagic Fever Virus.

Ecology and evolution
2026

GP38 is a structural component of Crimean-Congo hemorrhagic fever virus particles.

Virologica Sinica
2026

Amino Terminal Region of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Nucleocapsid (NP) Protein Contains Dominant Epitopes Recognised by Cellular Immunity.

Immunology
2026

High Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever Virus in Camels at Livestock Markets in Border Regions, Nigeria, 2023-2024.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2026

Crimean-congo hemorrhagic fever in Iraq, 2021-2024: epidemiological and clinical data analysis with proposed severity indicators for resource-constrained settings.

BMC infectious diseases
2026

Targeted organic acid profiling in Crimean-Congo hemorrhagic fever: A metabolomics-based approach to biomarker discovery.

Antiviral research
2025

First Detection of Jingmen Tick Virus in Hard Ticks Collected Across Multiple Regions of Italy.

Viruses
2026

The Outcome of PCR Versus IGM Timing Study in the Diagnosis of the Crimean-Congo Hemorrhagic Fever Outbreak in Iraq during 2021-2022.

Pharmaceutical nanotechnology
2026

From pandemic influenza to novel coronaviruses: emerging infectious diseases of the 21st century.

Diagnostic microbiology and infectious disease
2026

New markers predicting prognosis in patients with Crimean-Congo hemorrhagic fever: HDL cholesterol and eosinophil levels.

Pathogens and global health
2026

Hospital preparedness and operational adaptation for the safe management of Crimean-Congo haemorrhagic fever patients.

The Journal of hospital infection
2026

Field vaccination against CCHFV and Hyalomma tick infestation reduces multiple tick-borne infections in sheep.

NPJ vaccines
2026

In Silico Analysis of Potential Vaccine Antigens for the Treatment of Crimean-Congo Hemorrhagic Fever Virus (Cchfv).

Pharmaceutical research
2026

Identification and classification of Crimean-Congo hemorrhagic fever virus from Hyalomma asiaticum from southern Mongolia.

Ticks and tick-borne diseases
2026

Crimean-Congo hemorrhagic fever: serum neopterin levels and their relationship with clinical course.

Revista da Associacao Medica Brasileira (1992)
2026

Structure and function of the nairovirus cap-snatching endonuclease.

Nucleic acids research
2026

Identification of claramine and anidulafungin as entry inhibitors of Crimean-Congo hemorrhagic fever virus.

Antiviral research
2025

Discrimination of Hard Ticks by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).

International journal of molecular sciences
2026

Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.

NAR molecular medicine
2026

Thermodynamic Analysis of the Stability of the Crimean-Congo Hemorrhagic Fever Virus on Inanimate Surfaces.

Journal of medical virology
2026

A Compendium Review of the Global Epidemiology of Ticks and Tick-borne Diseases: Regional Insights from Türkiye.

Turkiye parazitolojii dergisi
2025

A multisectoral effort against Crimean-Congo hemorrhagic fever: Towards One Health approach implementation in the Balkans and Black Sea region.

One health (Amsterdam, Netherlands)
2025

Co-Circulation of Tick-Borne Bandaviruses and Orthonairoviruses Across Humans, Livestock, and Rats in Pakistan: Serologic Evidence and Public Health Implications.

Viruses
2025

Seroprevalence of Crimean-Congo Hemorrhagic Fever and Rift Valley Fever Viruses Among Ruminants in Nigeria: A Descriptive Epizootiological Analysis.

Pathogens (Basel, Switzerland)
2025

Serologic Evidence of Circulation of Six Arboviruses (Dengue Virus, Chikungunya Virus, Zika Virus, Rift Valley Virus, Yellow Fever Virus, Crimean-Congo Hemorrhagic Fever Virus) in Four Regions of Burkina Faso, West Africa.

Tropical medicine and infectious disease
2025

Transforming One Health in India: National Multisectoral Mixed Method Study on Prioritization of Zoonotic Diseases.

JMIR public health and surveillance
2026

Active transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).

Research in veterinary science
2025

An Overview of the Crimean-Congo Hemorrhagic Fever Outbreak in Iraq.

Open forum infectious diseases
2025

Spatiotemporal and clinical dynamics of Crimean-Congo Hemorrhagic Fever in Wasit Governorate, Iraq (2022-2025): a retrospective analytical study.

BMC infectious diseases
2025

Crimean-Congo hemorrhagic fever: An emerging threat in Europe.

Virologica Sinica
2025

Detection of Crimean-Congo hemorrhagic fever virus and Rift Valley fever virus antibodies in animal workers in Cameroon.

Frontiers in veterinary science
2026

Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.

The Journal of veterinary medical science
2025

The first detection of Jingmen tick virus (JMTV) in humans in Türkiye, 2022.

Pathogens and global health
2025

A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection.

NPJ vaccines
2025

Crimean-Congo Hemorrhagic Fever Virus in Cattle and Ticks, Israel.

Emerging infectious diseases
2026

Electrochemical immunosensor for sensitive detection of Crimean-Congo hemorrhagic fever virus based on a flexible electrode of carbon nanofibers modified with copper (II) phosphate nanoflowers.

Biosensors &amp; bioelectronics
2025

Comparison of Blood Parameters in Crimean-Congo Hemorrhagic Fever and Upper Respiratory Infection Patients with Similar Complaints.

Iranian journal of public health
2025

Neutralization of Crimean-Congo hemorrhagic fever pseudotyped virions with heavy chain antibodies.

Virologica Sinica
2026

Seroprevalence of four zoonotic viral diseases in camels in Qatar.

Journal of infection and public health
2025

The risk of human- and mammal-infecting tick-borne viruses in northwest China and adjacent countries.

Nature communications
2026

Crimean-Congo hemorrhagic fever virus localization and shedding in the reproductive tract of lethal and survivor mouse models.

Emerging microbes &amp; infections
2025

Chemical composition and acaricidal properties of essential oils from Cinnamomum mollifolium, Eucalyptus globulus, and Pimenta dioica against Hyalomma rufipes (Acari: Ixodidae).

BMC veterinary research
2025

Oral VV261 administration protects mice from lethal Crimean-Congo hemorrhagic fever virus challenge.

Journal of virology
2025

GenBank2PubMed: bridging viral genomic data and the scientific literature with AI-assisted curation.

Scientific reports
2025

RNA virome of ticks and fleas infesting Marmota himalayana from the Qinghai-Tibet plateau.

Animal microbiome
2025

Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice.

NPJ vaccines
2026

Diversity, distribution, and climate change impacts on tick fauna in Saudi Arabia: A comprehensive ecological niche modeling approach.

Microbial pathogenesis
2025

Genetic features of Orthonairovirus haemorrhagiae variants detected in ixodid ticks in Armenia.

PLoS neglected tropical diseases
2025

Descriptive Epidemiology of Acute Febrile Illness Patients in Nigeria: Pathogens of Global Public Health Significance Detected Using a Multi-Pathogen Detection Tool.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Brucellosis Seroprevalence and Diagnostic Challenges: A Comprehensive Review from 2017-2021.

Journal of clinical practice and research
2025

Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4'-fluorouridine therapy.

Journal of virology
2025

Epidemiology of the Crimean-Congo hemorrhagic fever virus.

Acta tropica
2025

Viral hemorrhagic fevers - therapeutic trial advances and challenges.

Expert review of anti-infective therapy
2026

Serosurveillance of Crimean-Congo hemorrhagic fever virus in zoo animals, Spain, 2007-2024.

Veterinary microbiology
2026

Design, synthesis and preliminary biological evaluation of novel carbamoyl pyridone derivatives as potent inhibitors of Crimean-Congo hemorrhagic fever virus.

European journal of medicinal chemistry
2025

Phenotypic and genetic changes of Crimean-Congo hemorrhagic fever virus during serial passage in susceptible cell lines.

Archives of virology
2025

Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2.

PLoS neglected tropical diseases
2025

Abdominal computed tomography findings in Crimean-Congo hemorrhagic fever: correlations with disease severity and prognostic implications.

Abdominal radiology (New York)
2025

[Spinal Epidural Abscess and Spondylodiscitis Following Crimean-Congo Hemorrhagic Fever: A Rare Post-Recovery Complication].

Mikrobiyoloji bulteni
2025

Acute Hepatic Failure in Crimean-Congo Hemorrhagic Fever: A Case Report.

Clinical case reports
2025

First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus Infections in Croatia: A Multispecies Surveillance Approach Emphasising the Role of Sentinel Hosts.

Viruses
2025

Prognostic Significance of CRP/Albumin, D-Dimer/Albumin, D-Dimer/Fibrinogen Ratios and Triglyceride-Glucose Index in Crimean-Congo Hemorrhagic Fever: A Prospective Observational Study.

Tropical medicine and infectious disease
2025

Serologic evidence of crimean-congo hemorrhagic fever virus exposure among livestock and farmers in the Democratic Republic of the Congo.

PLoS neglected tropical diseases
2025

Genetic evidence of regional circulation of Crimean-Congo hemorrhagic fever virus in ixodid ticks from southern Kazakhstan.

Frontiers in veterinary science
2025

Crimean-Congo Hemorrhagic Fever Disease: Relationship Between Clinical Course and Apoptosis.

Infectious diseases &amp; clinical microbiology
2025

Comparative evaluation of a multiplex polymerase chain reaction panel for high-consequence infectious diseases against conventional diagnostics in travelers with febrile diseases.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

A non-fatal Crimean-Congo hemorrhagic fever virus infection; The balanced cytokine responses on the outcome of the clinical disease.

Diagnostic microbiology and infectious disease
2025

Tracking invasion events: phylogeography of Hyalomma marginatum in the Mediterranean basin with a focus on Southern France.

Parasites &amp; vectors
2025

Evidence of Crimean-Congo hemorrhagic fever (CCHF) susceptibility among big felids in Namibia: leopards (Panthera pardus) and lions (Panthera leo).

Veterinaria italiana
2025

Striking tick-borne virus diversity and potential reservoirs documented during One-Health-based cross-sectional screening in Anatolia.

Parasites &amp; vectors
2026

A fatal case of Herpes simplex virus-2 infection imported from Sharjah to India: Need for differential diagnosis amid Mpox surveillance.

Diagnostic microbiology and infectious disease
2025

Genetic Diversification of Crimean-Congo Hemorrhagic Fever Virus Lineage Europe 1.

Annals of the New York Academy of Sciences
2025

Crimean-Congo Hemorrhagic Fever Virus Circulation in Wild European Rabbits, Portugal, 2018-2023.

Emerging infectious diseases
2025

Multicriteria Decision Analysis as a Tool for Assessing Vector-Borne Diseases Risk: The Case of Crimean-Congo Hemorrhagic Fever in Türkiye.

Microorganisms
2025

The first finding of Hyalomma rufipes in Poland in 2024: the promising start of a citizen science project.

Parasites &amp; vectors
2025

First detection of Crimean Congo Hemorrhagic Fever antibodies in cattle and wildlife of southern continental France: Investigation of explanatory factors.

PloS one
2025

Crimean-Congo hemorrhagic fever virus Africa 1 lineage in Hyalomma species ticks, Tunisia, 2024.

Journal of virology
2025

Silent killer strikes during Eid-Ul-Adha: Crimean-Congo hemorrhagic fever outbreak in Khyber Pakhtunkhwa, Pakistan, 2023.

Journal of infection and public health
2025

Development of a Rapid Diagnostic Test to Distinguish between Emerging Viruses That Cause Hemorrhagic Fever.

The American journal of tropical medicine and hygiene
2025

An orally available 4'-fluorouridine prodrug inhibits SFTSV and LCMV infection.

Journal of virology
2025

Evaluation of Clinical and Hematological Findings of Pediatric Patients with Crimean-Congo Hemorrhagic Fever.

Klinische Padiatrie
2025

CCHFV-M based DNA vaccine is highly immunogenic in multiple species and protects against challenge in cynomolgus macaques.

Antiviral research
2026

Crimean-Congo Hemorrhagic Fever Accompanied by Acalculous Cholecystitis and Pancytopenia: A Rare Case.

Turkish journal of haematology : official journal of Turkish Society of Haematology
2026

The first reported Crimean-Congo hemorrhagic fever reinfection in the literature: 11 years apart.

Diagnostic microbiology and infectious disease
2025

Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses.

Viruses
2025

Molecular Evolution and Phylogeography of the Crimean-Congo Hemorrhagic Fever Virus.

Viruses
2025

Molecular and Clinical Characterization of Crimean-Congo Hemorrhagic Fever in Bulgaria, 2015-2024.

Pathogens (Basel, Switzerland)
2025

Tick-Borne Pathogens in Companion Animals and Zoonotic Risk in Portugal: A One Health Surveillance Approach.

Microorganisms
2025

Identification of Hyalomma Ticks on Migratory Birds in Poland During the 2023 and 2024 Spring Seasons.

Life (Basel, Switzerland)
2025

Decoding blood fatty acids in Crimean-Congo hemorrhagic fever.

Metabolomics : Official journal of the Metabolomic Society
2025

Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus.

mBio
2025

Stability of the Crimean-Congo Hemorrhagic Fever Virus on Inanimate Surfaces and Implications for Infection Control.

Journal of medical virology
2025

Epigenetic modulation of ALKBH5, FTO and YTHDF2 genes in crimean-congo haemorrhagic fever patients depending on RNA methylation.

Molecular biology reports
2025

Relationship between vascular endothelial growth factor gene polymorphisms and Crimean-Congo hemorrhagic fever.

Revista da Associacao Medica Brasileira (1992)
2025

Genetic Variations in Crimean-Congo Hemorrhagic Fever Virus: Challenges for Molecular Diagnostic Assays-A Case Report.

Case reports in infectious diseases
2025

sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.

EMBO reports
2025

Hyalomma marginatum in Europe: The Past, Current Status, and Future Challenges-A Systematic Review.

Transboundary and emerging diseases
2025

Drivers of Crimean-Congo Hemorrhagic Fever in Natural Host and Effects of Control Measures, Bulgaria.

Emerging infectious diseases
2025

ZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein.

The Journal of biological chemistry
2025

Highly sensitive and multiplex detection of nine potential bioterrorism viral agents in a single reaction by multiplex probe amplification (MPA) with melting curve analysis.

Microbiology spectrum
2025

Chest computed tomography assessment of patients with crimean- congo hemorrhagic fever: a comparison between survivors and nonsurvivors.

Journal of vector borne diseases
2025

Harnessing Hazara Virus as a Surrogate for Crimean-Congo Hemorrhagic Fever Virus Enables Inactivation Studies at a Low Biosafety Level.

Pathogens (Basel, Switzerland)
2025

Tick-Borne Viruses in a Changing Climate: The Expanding Threat in Africa and Beyond.

Microorganisms
2025

In-silico study: Hm86 protein of Hyalomma marginatum (Ixodida) as a candidate to provide anti-tick vaccine.

Scientific reports
2025

Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies.

EBioMedicine
2025

Seroprevalence of Rift Valley and Crimean-Congo Hemorrhagic Fever Viruses, Benin, 2022-2023.

Emerging infectious diseases
2025

Crimean-Congo Hemorrhagic Fever Virus among Goats, Southern Bhutan.

Emerging infectious diseases
2025

Crimean-Congo Hemorrhagic Fever Virus Africa 1 Lineage in Hyalomma dromedarii Ticks, Algeria, 2023.

Emerging infectious diseases
2025

A comprehensive review on the epidemiology of arboviruses in the Eastern Mediterranean Region (EMRO): insights from the WHO's Regional Office.

GMS hygiene and infection control
2025

A Case of Crimean-Congo Hemorrhagic Fever Presenting to the Emergency Department with Postmenopausal Vaginal Bleeding.

The Journal of emergency medicine
2025

Evidence of Crimean-Congo hemorrhagic fever virus in livestock and wildlife in Northeastern Portugal.

Scientific reports
2025

Crimean-Congo Hemorrhagic Fever Outbreak in Podor, Northern Senegal in 2022: Two Independent Emergences and Unprecedented Mortality.

The American journal of tropical medicine and hygiene
2025

Tick-Borne Infectious Diseases in China, 2003-2023.

China CDC weekly
2025

Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda.

BMC infectious diseases
2024

Seroprevalence and factors associated with CCHF virus infection in cattle and sheep in Mopti region (Mali).

Archives of Razi Institute
2025

Insights into Crimean-Congo hemorrhagic fever virus exposure probability: a period cross-sectional study in wild and domestic ungulates.

Journal of medical entomology
2025

First report of Crimean-Congo hemorrhagic fever virus exposure in human and livestock populations, Center Region, Cameroon.

Frontiers in cellular and infection microbiology
2025

The Single Amino Acid Change of R516K Enables Efficient Generation of Vesicular Stomatitis Virus-Based Crimean-Congo Hemorrhagic Fever Reporter Virus.

Journal of medical virology
2025

Seroprevalence study for selected zoonotic vector-borne pathogens in sheep from endemic areas of Croatia.

Frontiers in veterinary science
2024

NMR side-chain assignments of the Crimean-Congo hemorrhagic fever virus glycoprotein n cytosolic domain.

Magnetic resonance (Gottingen, Germany)
2025

Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing.

Journal of virology
2025

Human tick biting and tick-borne disease risk in Türkiye: Systematic review.

PLoS neglected tropical diseases
2025

Factors associated with knowledge, attitudes, and practices of mixed crop-livestock farmers on Crimean-Congo hemorrhagic fever (CCHF) and other zoonoses in Burkina Faso.

One health (Amsterdam, Netherlands)
2025

Serosurveillance of Crimean-Congo hemorrhagic fever virus antibodies in livestock as a reservoir for human infection in Afghanistan.

One health (Amsterdam, Netherlands)
2024

Fatal Crimean-Congo Hemorrhagic Fever with an Atypical Clinical Course during the COVID-19 Pandemic.

Journal of arthropod-borne diseases
2025

Detecting spatial clusters of Crimean Congo hemorrhagic fever in Iraq in 2023.

Global epidemiology
2026

Treatment and management of Crimean-Congo hemorrhagic fever.

Journal of vector borne diseases
2025

Zoonotic arbovirus infections in cattle in Mozambique with special reference to Crimean-Congo hemorrhagic fever virus (CCHFV) and rift valley fever virus (RVFV).

Virology journal
2025

Exploring approaches and advancements in the development and evaluation of multi-epitope subunit vaccines against tick-borne viruses.

Veterinary microbiology
2025

Crimean-Congo hemorrhagic fever with severe bradycardia treated with Theophylline.

Revista da Sociedade Brasileira de Medicina Tropical
2025

Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge.

NPJ vaccines
2025

Successful Inactivation of High-Consequence Pathogens in PrimeStore Molecular Transport Media.

Viruses
2025

Persistent Infections in Tick Cell Lines: The Role of Viral-Derived DNA Forms in Hazara Virus Replication and Cellular Survival.

Viruses
2025

Association Between IL-28B (rs8099917) and IL-28B (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis.

Pathogens (Basel, Switzerland)
2025

Elevated interferon-induced transmembrane protein 3 in platelets and megakaryocytes suppresses Crimean-Congo hemorrhagic fever viral infection by interacting with glycoprotein Gc.

Virologica Sinica
2025

Semi-automated diagnostic RT-PCR as a screening assay for antiviral compounds in a 96-well format against highly pathogenic RNA viruses.

Advances in virus research
2025

Crimean-Congo Hemorrhagic Fever Virus Infections in Slaughtered Camels and Abattoir Workers in the United Arab Emirates.

Transboundary and emerging diseases
2025

Mucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine.

Cell research
2025

Deaths in animal attacks: A 10-year retrospective forensic analysis of direct and indirect causes.

Journal of forensic sciences
2025

Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.

PloS one
2025

Re-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case.

One health (Amsterdam, Netherlands)
2025

The nucleocapsid protein of Crimean-Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cells.

The Journal of biological chemistry
2025

A mouse model of Crimean-Congo hemorrhagic fever virus-induced coagulopathy.

Virologica Sinica
2025

Outbreak of Crimean-Congo hemorrhagic fever in Kyzylorda region, Kazakhstan, March-July 2022.

Frontiers in public health
2025

CO-OCCURRENCE OF HANTAVIRUS PULMONARY SYNDROME AND HEMORRHAGIC FEVER WITH RENAL SYNDROME.

Georgian medical news
2024

Exposure to Crimean-Congo Hemorrhagic Fever Virus in Wild Ungulates in the Basque Country, Northern Iberian Peninsula.

Transboundary and emerging diseases
2025

Evaluation of a Luminex-Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal.

Transboundary and emerging diseases
2025

Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.

Npj viruses
2025

Prognostic Value of Ratios of Inflammatory Markers in the Prognosis of Crimean-Congo Hemorrhagic Fever.

Tropical medicine and infectious disease
2025

The Growing Threat of Tick-Borne Viruses: Global Trends, Clinical Outcomes, and Diagnostic Strategies.

Viral immunology
2025

Prime-Boost Vaccination Based on Nanospheres and MVA Encoding the Nucleoprotein of Crimean-Congo Hemorrhagic Fever Virus Elicits Broad Immune Responses.

Vaccines
2025

A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.

Journal of neurovirology
2025

Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis.

Antiviral research
2025

Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.

mBio
2025

Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France).

One health (Amsterdam, Netherlands)
2025

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.

EBioMedicine
2025

Prevalence Rates and Outcomes of Hyponatremia in Patients with Crimean-Congo Hemorrhagic Fever.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2025

Development of FRET-based cap-snatching endonuclease assay.

Microbiology spectrum
2025

Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever Exposure in Wild and Domestic Animals in Benin.

Viruses
2025

Crimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges.

World journal of virology
2025

Author Correction: Spatial analysis and risk mapping of Crimean-Congo hemorrhagic fever (CCHF) in Sub-Saharan Africa.

Scientific reports
2025

Mapping the potential suitable habitats for Hyalomma rufipes (Acari: Ixodidae) in Africa and Western Eurasia.

PLoS neglected tropical diseases
2025

Drug repositioning as a promising approach for the eradication of emerging and re-emerging viral agents.

Molecular diversity
2025

Predictive role of non-viral leukocyte parameters in tracking the development and progression of Crimean-Congo hemorrhagic fever.

Microbial pathogenesis
2025

Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.

Antiviral research
2025

[Specific precautions against Crimean-Congo hemorrhagic fever in patients with general symptoms after a tick bite].

Gaceta sanitaria
2025

Molecular characterization and phylogenetic analysis of Crimean-Congo hemorrhagic fever virus, northwestern of Iran.

BMC infectious diseases
2025

Crimean-Congo hemorrhagic fever, a real health problem in Iraq?

IJID regions
2025

Emerging Arboviral Diseases in Pakistan: Epidemiology and Public Health Implications.

Viruses
2025

Crimean-Congo Hemorrhagic Fever Mimicking HELLP Syndrome in a Pregnant Woman and Her Infant in Kosovo: A Case Report.

Viruses
2025

Crimean-Congo hemorrhagic fever: Strategies for diagnosis at initial admission.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
2025

Two Human Infections with Diverse Europe-1 Crimean-Congo Hemorrhagic Fever Virus Strains, North Macedonia, 2024.

Emerging infectious diseases
2025

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread.

Science translational medicine
2025

Effectiveness of nucleoside analogs against Wetland virus infection.

Antiviral research
2025

Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda.

Emerging microbes &amp; infections
2025

Elucidating Infectious Causes of Fever of Unknown Origin: A Laboratory-Based Observational Study of Patients with Suspected Ebola Virus Disease, Guinea, 2014.

The Journal of infectious diseases
2025

Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.

Bioorganic &amp; medicinal chemistry
2025

Hidden threats: Brucellosis diagnosis and co-infection patterns in Crimean-Congo Hemorrhagic Fever suspects.

Diagnostic microbiology and infectious disease
2025

Lift-CM: An integrated lift-heater centrifugal microfluidic platform for point-of-care pathogen nucleic acid detection using isothermal amplification and CRISPR/Cas12a.

Biosensors &amp; bioelectronics
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Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Febre hemorrágica Crimeia-Congo (CCHF).

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Febre hemorrágica Crimeia-Congo (CCHF)

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean-Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross-Sectional Study.
    Health science reports· 2026· PMID 41782654mais citado
  2. Correction: Spatio-temporal distribution of Crimean-Congo Hemorrhagic Fever and its relationship with climate factors in Pakistan: A decade-long experience from tertiary care laboratory network.
    PloS one· 2026· PMID 41557656mais citado
  3. Active transmission of Crimean-Congo Hemorrhagic fever virus, a tick-borne disease, in Iraq: Animal host population movement dynamics and retrospective case study analysis (2018-2023).
    Research in veterinary science· 2026· PMID 41420935mais citado
  4. Pathogenicity of a novel orthonairovirus, Iwanai Valley virus, in mice.
    The Journal of veterinary medical science· 2026· PMID 41391868mais citado
  5. Temporal Changes in Sonographic Findings as Predictors of Disease Severity in Crimean-Congo Hemorrhagic Fever.
    Vector borne and zoonotic diseases (Larchmont, N.Y.)· 2026· PMID 41874270mais citado
  6. Detection and genetic characterization of Crimean-Congo hemorrhagic fever virus in ticks from western Spain (2017, 2020-2024).
    Front Vet Sci· 2026· PMID 41994259recente
  7. Systematic review and meta-analysis for the occurrence of Crimean-Congo hemorrhagic fever, Tularemia, and Rift Valley fever in pastoralist systems in Africa.
    Front Vet Sci· 2025· PMID 41988555recente
  8. One Health Living Lab: A Collaborative and Novel Approach to Zoonotic Public Health Challenges in Portugal.
    Health Secur· 2026· PMID 41987533recente
  9. ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction.
    bioRxiv· 2026· PMID 41959182recente
  10. Prognostic Value of Admission Glucose and Extended Lipid Profile in Patients with Crimean-Congo Hemorrhagic Fever.
    J Med Virol· 2026· PMID 41949320recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:99827(Orphanet)
  2. MONDO:0020501(MONDO)
  3. GARD:19690(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q1077505(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Febre hemorrágica Crimeia-Congo (CCHF)
Compêndio · Raras BR

Febre hemorrágica Crimeia-Congo (CCHF)

ORPHA:99827 · MONDO:0020501
Prevalência
Unknown
CID-10
A98.0 · Febre hemorrágica da Criméia (do Congo)
CID-11
Ensaios
4 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0019099
Repurposing
22 candidatos
aspirincyclooxygenase inhibitor
chloramphenicolbacterial 50S ribosomal subunit inhibitor
chloramphenicol-palmitateprotein synthesis inhibitor
+17 outros
EuropePMC
Wikidata
Wikipedia
Papers 10a
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