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CLIPPERS
ORPHA:284448CID-10 · G04.8CID-11 · 8E4A.0DOENÇA RARA

Los Angeles Clippers é uma equipe norte-americana de basquete profissional localizada no Condado de Los Angeles. O time compete na National Basketball Association (NBA) como membro da Divisão do Pacífico da Conferência Oeste. Os Clippers disputam suas partidas em casa no Intuit Dome, ginásio próprio inaugurado em 2024, após anos dividindo arena com o rival Los Angeles Lakers.

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Introdução

O que você precisa saber de cara

📋

CLIPPERS é uma encefalopatia autoimune rara caracterizada por lesões pontuais hiperintensas em T2/FLAIR na substância branca cerebelar e do tronco encefálico. Causa ataxia, disartria e nistagmo, com melhora clínica e radiológica após tratamento com corticosteroides.

Publicações científicas
384 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
50
pacientes catalogados
Início
Adult
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G04.8
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico384PubMed
Últimos 10 anos200publicações
Pico201931 papers
Linha do tempo
2026Hoje · 2026🧪 2015Primeiro ensaio clínico📈 2019Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

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Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

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·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 1 ensaio
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — CLIPPERS

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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

1 ensaios clínicos encontrados.

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Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
273 papers (10 anos)
#1

Peripheral T-Cell Lymphoma Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids: A Case Report with Confirmatory Brain Biopsy and Longitudinally Extensive Transverse Myelitis.

Case reports in neurology2026

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a steroid-responsive relapsing-remitting disorder of the central nervous system (CNS). However, CLIPPERS-like presentations have been increasingly recognized as potential early manifestations of underlying lymphoma, most commonly B-cell types. T-cell lymphomas in this context remain exceedingly rare. We report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), mimicking CLIPPERS with confirmatory brain biopsy. A 33-year-old man initially presented with pontocerebellar dysfunction and punctate gadolinium-enhancing hindbrain lesions, fulfilling diagnostic criteria for probable CLIPPERS. He achieved transient remission with corticosteroids but later developed relapsing neurological and pulmonary symptoms, radiological progression with supratentorial and spinal involvement including longitudinally extensive transverse myelitis (LETM), and steroid resistance. Despite nondiagnostic lung biopsy and the absence of malignant cells on cerebrospinal fluid (CSF) cytology, CSF circulating tumor DNA (ctDNA) analysis revealed pathogenic mutations in FAS and TET2. Stereotactic biopsy of a right frontal lesion ultimately confirmed PTCL-NOS. The patient's disease progressed despite chemotherapy, leading to death 6 months after diagnosis. This case highlights that CNS infiltration by PTCL-NOS can closely mimic CLIPPERS both clinically and radiologically. LETM may represent an additional warning feature in such presentations. Vigilance for clinical and radiologic red flags, the adjunctive use of CSF ctDNA analysis, and early reconsideration of diagnosis with timely biopsy should be emphasized to improve outcomes in patients with CLIPPERS-like syndromes.

#2

CLIPPERS mimicking multifocal brain metastases: a diagnostic challenge.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026 Feb 27
#3

Surgical management of intentional ingestion of two nail clippers in an incarcerated adult: a case report.

International journal of surgery case reports2026 Mar

Foreign body (FB) ingestion is a frequent concern in emergency settings. Intentional ingestion of FBs in adults is more common among incarcerated individuals. Complications such as impaction, perforation, hemorrhage, and obstruction may arise, necessitating prompt evaluation. We report a case of a 26-year-old incarcerated male who presented to the emergency department after ingesting two nail clippers simultaneously. He complained of epigastric pain. Plain abdominal radiography revealed two objects in the stomach. Given the sharp nature of the FBs, his symptoms, and the risk of complications, a contrast-enhanced CT scan was performed, showing no additional findings. Endoscopic retrieval was unsuccessful, and he subsequently underwent open gastrostomy, which successfully removed the objects. Postoperative recovery was uneventful. Most gastrointestinal FBs pass spontaneously without intervention. However, outcomes differ significantly in incarcerated populations. Clinical presentation ranges from asymptomatic cases to acute abdomen. Management is challenging due to the variable size, shape, and sharpness of ingested objects. Abdominal radiography remains the first-line diagnostic tool. Treatment may include observation, endoscopic removal, or surgical intervention, depending on the clinical context. Although many FBs pass spontaneously or are retrieved endoscopically, some require surgery. Gastrostomy is widely accepted for the surgical removal of ingested FBs. Incarcerated individuals represent a unique clinical population in which intentional FB ingestion reflects complex behavioral patterns, posing therapeutic challenges and a high risk of recurrence. Delayed diagnosis may lead to serious complications. Psychiatric evaluation and preventive measures are essential to reduce recurrence in incarcerated patients.

#4

Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant.

Journal of clinical immunology2026 Mar 04

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a central nervous system (CNS) inflammatory disease characterized by contrast-enhanced MRI findings of salt-and-pepper-like lesions predominantly affecting the brainstem and cerebellum. We report two patients with CLIPPERS-like brain MRI findings who carried the same missense UNC13D variant in one allele along with deleterious variants in the opposite allele. Patient 1, a 23-year-old female, presented at 15 years of age with neurological symptoms and an MRI showing spontaneously resolving, contrast-enhancing lesions in the cerebellum. At age 16, the patient experienced an episode with systemic manifestations followed by recurrent CNS lesions that responded to steroid therapy. At age 22, the patient developed punctate to nodular contrast-enhancing lesions in the brainstem, cerebellum, and cerebrum, findings consistent with CLIPPERS. Patient 2, an 18-year-old female, presented at age 11 with ataxia and dysarthria, and an MRI showing multiple contrast-enhancing lesions in the cerebellum and brainstem, consistent with CLIPPERS MRI findings. Cerebellar biopsy revealed perivascular CD4+ T-lymphocyte infiltration, and the patient responded to steroid therapy, leading to an initial diagnosis of CLIPPERS. These patients were suspected of having inborn errors of immunity and were identified to have compound heterozygous UNC13D variants along with downregulated Munc13-4 protein. Both patients underwent allogeneic hematopoietic cell transplantation, with patient 1 remaining neurologically stable for two years post-transplantation, while patient 2 experienced a post-transplant relapse requiring steroid therapy. These cases highlight that biallelic variants in the UNC13D gene may cause CNS-predominant inflammation that mimics CLIPPERS. [Image: see text] The online version contains supplementary material available at 10.1007/s10875-026-01988-1.

#5

A case report of CLIPPERS involving brainstem, cerebellum, white matter of cerebral hemisphere, spinal cord and corpus callosum.

Radiology case reports2026 May

CLIPPERS (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) is a rare inflammatory disorder of the central nervous system. We describe a case with an atypical disease course and unusual imaging features, broadening the radiological spectrum of this condition. An adult male presented with acute gait instability. Neurological examination revealed upper motor neuron signs, including hyperreflexia and patellar/ankle clonus. Brain and spinal MRI demonstrated characteristic punctate, gadolinium-enhancing lesions in the pons, cerebellum, and spinal cord. Symptoms improved markedly with high-dose corticosteroid therapy. However, over a 5-year follow-up, the patient experienced several clinical relapses, each associated with steroid taper or discontinuation. Subsequent MRI during relapses revealed new, atypical lesions within the corpus callosum in addition to the classic findings. Long-term disease control was ultimately achieved with mycophenolate mofetil, an immunosuppressive agent, which maintained clinical and radiological remission. This case highlights that probable CLIPPERS can involve atypical structures such as the corpus callosum, which should not preclude the diagnosis. The relapsing-remitting course underscores the importance of long-term monitoring and the critical role of immunosuppressive agents in sustaining remission. Early initiation of steroid-sparing immunosuppressants should be considered for patients with a relapsing disease course.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC277 artigos no totalmostrando 192

2026

Surgical management of intentional ingestion of two nail clippers in an incarcerated adult: a case report.

International journal of surgery case reports
2026

Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant.

Journal of clinical immunology
2026

A case report of CLIPPERS involving brainstem, cerebellum, white matter of cerebral hemisphere, spinal cord and corpus callosum.

Radiology case reports
2026

CLIPPERS mimicking multifocal brain metastases: a diagnostic challenge.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

SLIPPERS Reconsidered: Clinical, Radiological, and Pathological Overlap with PACNS-A Case Report.

Reports (MDPI)
2026

Peripheral T-Cell Lymphoma Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids: A Case Report with Confirmatory Brain Biopsy and Longitudinally Extensive Transverse Myelitis.

Case reports in neurology
2026

Familial hemophagocytic lymphohistiocytosis type 2 mimicking CLIPPERS syndrome.

Medicina clinica
2025

From CLIPPERS to SLIPPERS: a case report supporting the expanding spectrum of steroid-responsive perivascular CNS inflammation.

Acta neurologica Belgica
2025

A case report of CLIPPERS syndrome with gait and cognitive impairment.

BMC neurology
2026

Dermatophyte contamination of hair clippers and cleaning brushes in Copenhagen hair salons.

Journal of the European Academy of Dermatology and Venereology : JEADV
2025

Expanding the Clinical, Radiological, and Pathological Spectrum of SLIPPERS-A Rare Steroid-Responsive Neuroinflammation.

Neurology India
2025

Nickel and Cobalt Release From Hairdressing Tools in German Barbershops.

Contact dermatitis
2025

CLIPPERS syndrome following papillary thyroid carcinoma.

BMJ case reports
2025

Role of advanced MRI in diagnosing and evolutive follow-up to treatment in a case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).

Radiology case reports
2025

CLIPPERs - Clip the right protein - a new tool for targeted proteolysis in bacteria.

EMBO reports
2025

[Hygiene recommendations for regional anesthesia : Updated S1 guidelines of the working group regional anesthesia of the German Society for Anesthesiology].

Die Anaesthesiologie
2025

The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes.

Kidney international
2025

Probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids syndrome: management with corticosteroids and intravenous immunoglobulin-a case report.

Journal of medical case reports
2025

CLIPPERS syndrome: a case report and differential diagnosis review.

Postepy psychiatrii neurologii
2025

Uncommon Non-MS Demyelinating Disorders of the Central Nervous System.

Current neurology and neuroscience reports
2025

Targeted protein degradation in Escherichia coli using CLIPPERs.

EMBO reports
2025

An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids for Over Four Years.

Internal medicine (Tokyo, Japan)
2025

A Case of Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids (SLIPPERS) with Associated Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) and a Review of Literature.

Annals of Indian Academy of Neurology
2025

Nosocomial transmission of Sporothrix brasiliensis in two cats.

Topics in companion animal medicine
2025

Clinical and imaging characteristics of corticosteroid-responsive chronic lymphocytic inflammation with Pontine perivascular enhancement syndrome (CLIPPERS): an analysis of 9 cases.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Electric nail clipper entanglement injury: A new form of injury in young children.

The American journal of emergency medicine
2025

Dental disease in rabbits under UK primary veterinary care: Clinical management and associated welfare impacts.

The Veterinary record
2025

Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report.

SAGE open medical case reports
2025

Diagnostic challenges in SLIPPERS syndrome: Case report.

Multiple sclerosis journal - experimental, translational and clinical
2025

Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids Presenting With Predominantly Neuro-Ophthalmic Features.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2024

Evaluating and Improving Surgical Site Infection Prevention: Outcomes of a Two-Cycle Audit and Targeted Interventions in a Low-Resource Setting.

Cureus
2024

Navigating the Mysteries of CLIPPERS Syndrome: A Case Report of Long-Term Follow-Up.

Clinical case reports
2025

KLHL11-associated rhomboencephalitis presenting as clippers-like syndrome.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2024

Case report: Hand-arm vibration syndrome in a dental technician.

Frontiers in public health
2024

Monoclonal Gammopathy of Neurological Significance in a Patient With Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS Syndrome): A Case Report of a Rare Entity.

Cureus
2024

Erdheim-Chester Disease Masquerading as CLIPPERS.

Neurology(R) neuroimmunology &amp; neuroinflammation
2024

[The central vein sign in the differential diagnosis of multiple sclerosis].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2024

A case of central sleep apnea associated with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
2024

Headache As the Sole Symptom in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): A Case Report and Literature Review.

Cureus
2024

[Pseudofolliculitis barbae in police students in Dakar: epidemiological and clinical aspects, and associated risk factors].

Medecine tropicale et sante internationale
2024

The Indian multiple sclerosis and allied demyelinating disorders registry and research network (IMSRN): Inception to reality.

Multiple sclerosis and related disorders
2024

CLIPPERS With Supratentorial Brain and Cord Enhancement.

The Neurohospitalist
2024

Clinicoradiological features of probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome.

BMJ case reports
2024

Hepatitis B Virus Prevalence and Transmission in the Households of Pregnant Women in Kinshasa, Democratic Republic of Congo.

Open forum infectious diseases
2024

Immunosuppressive Therapy Reversing Obstructive Hydrocephalus in CLIPPERS.

Neurology
2024

Unusual CLIPPERS presentation with a predominant spinal cord involvement: case report and review of the literature.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2024

Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study.

American journal of veterinary research
2024

Familial hemophagocytic lymphohistiocytosis: from macrophage activation syndrome to CLIPPERS.

Journal of neurology
2023

A New Perspective on Partial Nail Avulsion: Surgical Pearl.

Journal of cutaneous and aesthetic surgery
2024

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): contemporary advances and current controversies.

Journal of neurology
2024

Postoperative surgical site infection after preoperative use of razor versus clipper for hair removal in inguinal hernia surgery: A quasi-randomized clinical trial.

Health science reports
2024

Microbes on Clipper Blades after Use and Disinfection in Small Animal- and Equine Practice.

Veterinary sciences
2024

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review.

Clinical case reports
2023

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector.

Scientific reports
2023

Nickel release from hairdressing tools in the United States.

Contact dermatitis
2023

Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids (SLIPPERS)-Does it Really Exist?

Brain sciences
2023

A Case of Radiologically Compatible Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) With Demyelinating Lesions.

Cureus
2023

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS Syndrome): A Case Report and Literature Review.

Case reports in neurological medicine
2024

Return to Sports Following Sports-Related Concussion in Collision Sports: An Expert Consensus Statement Using the Modified Delphi Technique.

Arthroscopy : the journal of arthroscopic &amp; related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
2024

On-Field and Pitch-Side (Sideline) Assessment of Sports Concussion in Collision Sports: An Expert Consensus Statement Using the Modified Delphi Technique.

Arthroscopy : the journal of arthroscopic &amp; related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
2023

Pediatric CLIPPERS? Think again!

Journal of the neurological sciences
2023

The Elusive SLIPPERS Syndrome (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids): A Case Report and Literature Review.

International medical case reports journal
2023

CLIPPERS manifesting with dizziness: Recognizable and treatable.

SAGE open medical case reports
2023

Brain MRI Findings of Hemophagocytic Lymphohistiocytosis With a Heterozygous PRF1 Gene Mutation Masquerading As CLIPPERS: A Case Report.

Cureus
2023

Spectrum of Autoimmune Diseases-Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)-Clinical Case.

Medicina (Kaunas, Lithuania)
2023

Efficacy of Intravenous Immunoglobulins against Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids: A Case Report.

Case reports in neurology
2023

The pathogenesis hypothesis and research progress of CLIPPERS: A literature review.

Medicine
2023

CLIPPERS Syndrome After Vaccination. An Unusual ASIA Presentation.

Reumatologia clinica
2023

Effects of Depilatory Cream Formulation and Contact Time on Mouse Skin.

Journal of the American Association for Laboratory Animal Science : JAALAS
2022

Punctate Enhancement of Bilateral Basal Ganglia in a Case of Epstein-Barr Virus Encephalitis.

Case reports in neurology
2023

Corrigendum to "CLIPPERS: Multiparametric and quantitative MRI features" [Radiology Case Reports 18 (2023) 368-376].

Radiology case reports
2022

Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review.

Frontiers in veterinary science
2023

Surgical Site Infection Prevention: A Review.

JAMA
2023

CLIPPERS: Multiparametric and quantitative MRI features.

Radiology case reports
2023

CLIPPERS Responsive to Cladribine as a Durable Steroid-Sparing Agent.

Neurology(R) neuroimmunology &amp; neuroinflammation
2022

MOG antibody associated disease (MOGAD) presenting with extensive brain stem encephalitis: A case report.

eNeurologicalSci
2022

A rare case report of primary Sjögren's syndrome with clinical characteristics similar to those of CLIPPERS.

BMC neurology
2023

Salt-and-pepper appearance pontine and cerebellar enhancing lesions in CLIPPERS.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2023

On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models.

The FEBS journal
2021

The external carotid artery as a rare feeder of a spinal dural arteriovenous fistula causing cervical myelopathy: A review of the literature.

Brain &amp; spine
2022

Clinical characteristics, management, and outcomes of CLIPPERS: A comprehensive systematic review of 140 patients from 100 studies.

Multiple sclerosis and related disorders
2022

[18F]FDG brain PET findings in CLIPPERS at diagnosis and therapeutic follow-up.

European journal of nuclear medicine and molecular imaging
2022

Three-Dimensional-Printed Mechanical Transmission Element with a Fiber Bragg Grating Sensor Embedded in a Replaceable Measuring Head.

Sensors (Basel, Switzerland)
2022

Case Report: A Case With MOGAD and Anti-NMDAR Encephalitis Overlapping Syndrome Mimicing Radiological Characteristics of CLIPPERS.

Frontiers in immunology
2022

MOG autoimmunity mimicking CLIPPERS syndrome: Case report and literature review.

Journal of neuroimmunology
2022

Hepatitis B and C seroprevalence among residents in Lagos State, Nigeria: A population-based survey.

The Nigerian postgraduate medical journal
2022

Clinical Profile and Treatment Outcome in MOGAD: A Single-Center Case-Series Study in Guiyang, China.

Frontiers in neurology
2023

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome: Treatment approach depends on disease course.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
2022

Nickel release from metal tools in United States barbershops.

International journal of dermatology
2022

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) With Extrapontine and Pulmonary Involvement: Case Report of a Rare Presentation and Review of Literature.

Neurology India
2022

Surgical site infections due to razor-mediated hair removal in dermatologic surgery: A retrospective cohort study.

Journal of the American Academy of Dermatology
2022

Assessment of 2 Hair Removal Methods in New Zealand White Rabbits (Oryctolagus cuniculus).

Journal of the American Association for Laboratory Animal Science : JAALAS
2022

Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids: An Acute Presentation.

Cureus
2022

Bistable and Multistable Actuators for Soft Robots: Structures, Materials, and Functionalities.

Advanced materials (Deerfield Beach, Fla.)
2022

Brain biopsy in patients with CLIPPERS syndrome: why and when.

Therapeutic advances in neurological disorders
2022

Endoscopic foreign body retrieval from the caecum - A case report and push for intervention guidelines.

International journal of surgery case reports
2021

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids May Extend above and below Pons and Is Associated with Other Autoimmune Diseases.

Life (Basel, Switzerland)
2021

Thermographic Fault Diagnosis of Ventilation in BLDC Motors.

Sensors (Basel, Switzerland)
2022

"Recommendations for periprosthetic joint infections (PJI) prevention: the European Knee Associates (EKA)-International Committee American Association of Hip and Knee Surgeons (AAHKS)-Arthroplasty Society in Asia (ASIA) survey of members".

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
2021

CLIPPERS, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A challenge in neurological practice, clinical landmarks (Review).

Experimental and therapeutic medicine
2021

Preoperative hair removal to reduce surgical site infection.

The Cochrane database of systematic reviews
2021

Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: A case report and literature review.

Surgical neurology international
2021

Autoimmune Brainstem Encephalitis: An Illustrative Case and a Review of the Literature.

Journal of clinical medicine
2021

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after SARS-CoV-2 pneumonia.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

CLIPPERS associated with hypersensitivity pneumonitis: a case report.

Radiology case reports
2021

[Inflammatory diseases of the central nervous system].

Der Radiologe
2021

A case report of CLIPPERS syndrome and literature review.

Medicine
2021

Exploring the Intersection of Isolated-CNS Hemophagocytic Lymphohistiocytosis and Pediatric Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids.

Journal of child neurology
2021

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, a mimicker of malignancy: a case report and review of the literature.

Journal of medical case reports
2021

A RARE BRAINSTEM INFLAMMATORY SYNDROME, CLIPPERS, MYTH OR FACT. CASE REPORT WITH CRITICAL REVIEW.

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2021

Primary CNS lymphoma after CLIPPERS: a case series.

Journal of neurology, neurosurgery, and psychiatry
2021

CLIPPERS With Exclusive Extra Pontine Involvement.

Neurology(R) neuroimmunology &amp; neuroinflammation
2021

"Peppering the pons": CLIPPERS or myelin oligodendrocyte glycoprotein associated disease?

Multiple sclerosis and related disorders
2021

Parotid carcinoma following chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: a case report.

BMC neurology
2021

Hemophagocytic Lymphohistiocytosis Gene Mutations in Adult Patients Presenting With CLIPPERS-Like Syndrome.

Neurology(R) neuroimmunology &amp; neuroinflammation
2021

CLIPPERS syndrome: A case report in a Chinese patient with juxtacortical lesions.

Multiple sclerosis and related disorders
2021

Chronic lymphocytic infiltration with pontine perivascular enhancement responsive to steroids (CLIPPERS) and its association with Epstein-Barr Virus (EBV)-related lymphomatoid granulomatosis: a case report.

BMC neurology
2021

Co-occurrence of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and posterior reversible encephalopathy syndrome: a case report.

Multiple sclerosis and related disorders
2021

Increased Number of Perivascular CD20-Positive B Lymphocytes in the Neuropathology of CLIPPERS: Findings of 6 Patients from Mainland China.

European neurology
2021

Effect of Different Nail Penetration Enhancers in Solid Lipid Nanoparticles Containing Terbinafine Hydrochloride for Treatment of Onychomycosis.

AAPS PharmSciTech
2021

NMDAR antibody encephalitis overlapping with CLIPPERS syndrome in a psoriasis patient on adalimumab.

Journal of neurology
2020

A Case Report of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Diagnosed After Long Term Diagnosis of Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids.

Frontiers in neurology
2020

An Atypical Presentation of CLIPPERS, a Challenging Diagnosis of Reversible Early-Onset Dementia.

Case reports in neurology
2021

Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy.

Immunotherapy
2021

A case of diffuse large B cell lymphoma initially presenting as CLIPPERS: possible role of the Epstein-Barr virus.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2020

Area Postrema Syndrome: A Rare Feature of Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids.

Frontiers in neurology
2020

Tail Docking of Piglets 2: Effects of Meloxicam on the Stress Response to Tail Docking.

Animals : an open access journal from MDPI
2020

[A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) without relapse after early steroid treatment].

Rinsho shinkeigaku = Clinical neurology
2020

Prevalence and Detection of qac Genes from Disinfectant-Resistant Staphylococcus aureus Isolated from Salon Tools in Ishaka Town, Bushenyi District of Uganda.

The Canadian journal of infectious diseases &amp; medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
2020

[Overlap syndrome between primary T cell-mediated vasculitis of the brainstem and chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids (CLIPPERS)].

Der Nervenarzt
2020

Challenging Implications of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids Syndrome with an Atypical Presentation: Report of Two Cases.

World neurosurgery
2020

[Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2020

Mapping carbon and nitrogen isotopic composition of fingernails to demonstrate a rural-urban nutrition transition in the Center-West, Northeast, and Amazon regions of Brazil.

American journal of physical anthropology
2020

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with simultaneous presentation of Hashimoto thyroiditis.

Acta neurologica Belgica
2022

A Nationwide Epidemiological Analysis of Finger Infections Presenting to Emergency Departments in the United States From 2012 to 2016.

Hand (New York, N.Y.)
2020

Teaching students with autism spectrum disorder to tolerate haircutting.

Journal of applied behavior analysis
2023

Scalp verruca from barber clippers: An epidemiologic assessment of a common fomite.

Journal of the American Academy of Dermatology
2020

CLIPPERS, a syndrome of lymphohistiocytic disorders.

Multiple sclerosis and related disorders
2020

[A man in his sixties with gait ataxia, dysarthria and mild cognitive impairment].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
2019

Distribution of hepatitis B virus-positive individuals in Zaria, Nigeria, according to risk-associated practices.

Calabar journal of health sciences
2020

Implementation of a comprehensive unit-based safety program to reduce surgical site infections in cesarean delivery.

American journal of infection control
2020

CLIPPERS syndrome: A case report.

Neurologia
2019

CLIPPERS: a recognizable image of a treatable disease.

Arquivos de neuro-psiquiatria
2020

Within a hair's breadth - Factors influencing hair cortisol levels in pigs and cattle.

General and comparative endocrinology
2019

Atypical Pediatric Demyelinating Diseases of the Central Nervous System.

Current neurology and neuroscience reports
2019

[CLIPPERS syndrome with supratentorial and spinal cord involvement and histological anomalies].

Der Nervenarzt
2019

Peripheral T cell lymphoma after chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): a case report.

BMC neurology
2020

CLIPPERS: A case report with radiology, three serial biopsies and a literature review.

Clinical neuropathology
2020

Hangnails: Paste them back.

Pediatric dermatology
2019

[CLIPPERS syndrome - a disorder with many faces- a case report].

Fortschritte der Neurologie-Psychiatrie
2019

'Biofilm Clippers'- enzyme formulation for bovine mastitic biofilm therapy.

Microbial pathogenesis
2020

Relative Magnetic Force Measures and Their Potential Role in MRI Safety Practice.

Journal of magnetic resonance imaging : JMRI
2020

Steroid pulse therapy of radiological disease activity without clinical relapse in CLIPPERS.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2020

Influence of season and pituitary pars intermedia dysfunction on hair cortisol concentration in horses.

Domestic animal endocrinology
2019

Olivary hypertrophy improved by steroid treatment: Two case reports with unique presentations.

Journal of neuroimmunology
2019

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): A Rare Treatable Neuroradiological Spectrum.

Cureus
2019

Unusual CLIPPERS presentation and role of MRI examination in the proper diagnostic assessment: A case report.

European journal of radiology open
2019

Hemidysgeusia, phantosmia and respiratory arrest: a case of CLIPPERS.

BMJ case reports
2019

Diffuse white matter alteration in CLIPPERS: Advanced MRI findings from two cases.

Journal of the neurological sciences
2019

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with or without lymphoma: Comparison of clinical features and risk factors suggestive of underlying lymphomas.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2019

Does a Care Bundle Reduce Racial Disparities in Postcesarean Surgical Site Infections?

American journal of perinatology
2019

CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.

Journal of neurology, neurosurgery, and psychiatry
2019

Revisiting Perioperative Hair Removal Practices.

AORN journal
2019

Intrafamilial Transmission of Hepatitis C Virus Among Families of Infected Pediatric Oncology Patients.

The Pediatric infectious disease journal
2019

Penile Prosthesis Infection: Myths and Realities.

The world journal of men's health
2019

A case of CLIPPERS syndrome responsive to tocilizumab.

Neurology(R) neuroimmunology &amp; neuroinflammation
2019

Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Internal medicine (Tokyo, Japan)
2019

CLIPPERS Spectrum Disorder: A Rare Pediatric Neuroinflammatory Condition.

Child neurology open
2019

Quantitative Statistics and Identification of Tool-Marks.

Journal of forensic sciences
2020

Sedative and physiologic effects of tiletamine-zolazepam following buccal administration in cats.

Journal of feline medicine and surgery
2019

Reducing Cesarean Delivery Surgical Site Infections: A Resident-Driven Quality Initiative.

Obstetrics and gynecology
2019

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in limited cutaneous sclerosis: a rare disease combination.

BMJ case reports
2019

Evaluation of 4 Presurgical Skin Preparation Methods in Mice.

Journal of the American Association for Laboratory Animal Science : JAALAS
2018

Switch from previous major depression comorbid with CLIPPERS to mania-like episode following glucocorticosteroid therapy: a case report.

General psychiatry
2018

Comparison of costs and outcomes of patients presenting with a rare brainstem syndrome.

eNeurologicalSci
2019

CLIPPERS: An Increasingly Recognized Chronic Inflammatory Central Nervous System Disorder.

The American journal of medicine
2018

Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Radiology
2019

Growing the phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children.

Developmental medicine and child neurology
2018

Two cases of CLIPPERS with increased number of perivascular CD20-positive B lymphocytes.

Brain : a journal of neurology
2018

CLIPPERS syndrome responsive to Leflunomide: A case report.

Multiple sclerosis and related disorders
2019

Is chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in children the same condition as in adults?

Developmental medicine and child neurology
2019

Isolated painful trigeminal neuropathy as an unusual presentation of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report.

Cephalalgia : an international journal of headache
2018

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids with seizures and central pyrexia, in a patient requiring tracheal intubation and mechanical ventilation: A case report.

Journal of the Intensive Care Society
2018

Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Frontiers in immunology
2018

Perioperative hair removal: A review of best practice and a practice improvement opportunity.

Journal of perioperative practice
2018

Classification and diagnostic criteria for demyelinating diseases of the central nervous system: Where do we stand today?

Revue neurologique
2019

Idiopathic Central Nervous System Inflammatory Disease in the Setting of HLA-B27 Uveitis.

Ocular immunology and inflammation
2018

Blood and virus detection on barber clippers.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
2018

[Selected risk factors for occupational exposures to blood-borne pathogens in cosmetics salons].

Medycyna pracy
2018

Effective treatment of CLIPPERS with long-term use of rituximab.

Neurology(R) neuroimmunology &amp; neuroinflammation
2018

CLIPPERS: A Treatable Cause of Spastic Ataxia.

Movement disorders clinical practice
2018

A cerebral phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report and review of the literature.

Multiple sclerosis and related disorders
Ver todos os 277 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Peripheral T-Cell Lymphoma Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids: A Case Report with Confirmatory Brain Biopsy and Longitudinally Extensive Transverse Myelitis.
    Case reports in neurology· 2026· PMID 41550451mais citado
  2. CLIPPERS mimicking multifocal brain metastases: a diagnostic challenge.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2026· PMID 41749027mais citado
  3. Surgical management of intentional ingestion of two nail clippers in an incarcerated adult: a case report.
    International journal of surgery case reports· 2026· PMID 41837082mais citado
  4. Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant.
    Journal of clinical immunology· 2026· PMID 41781714mais citado
  5. A case report of CLIPPERS involving brainstem, cerebellum, white matter of cerebral hemisphere, spinal cord and corpus callosum.
    Radiology case reports· 2026· PMID 41756550mais citado
  6. Autoimmune maladies of the brainstem.
    Handb Clin Neurol· 2026· PMID 41896006recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:284448(Orphanet)
  2. MONDO:0017297(MONDO)
  3. GARD:10779(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q29103411(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

CLIPPERS
Compêndio · Raras BR

CLIPPERS

ORPHA:284448 · MONDO:0017297
Prevalência
<1 / 1 000 000
Casos
50 casos conhecidos
Herança
Not applicable
CID-10
G04.8 · Outras encefalites, mielites e encefalomielites
CID-11
Início
Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C3854437
EuropePMC
Wikidata
Papers 10a
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