Raras
Buscar doenças, sintomas, genes...
Coccidioidomicose
ORPHA:228123CID-10 · B38.0CID-11 · 1F25DOENÇA RARA

Infecção fúngica causada por Coccidioides immitis. Os indivíduos afetados geralmente apresentam sintomas leves semelhantes aos da gripe. Entretanto, a pneumonia e o envolvimento sistêmico com formação de abscessos podem evoluir como complicações da doença.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Infecção fúngica causada por Coccidioides immitis. Os indivíduos afetados geralmente apresentam sintomas leves semelhantes aos da gripe. Entretanto, a pneumonia e o envolvimento sistêmico com formação de abscessos podem evoluir como complicações da doença.

Pesquisas ativas
2 ensaios
101 total registrados no ClinicalTrials.gov
Publicações científicas
3.234 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: B38.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
6 sintomas
🦴
Ossos e articulações
5 sintomas
🧠
Neurológico
4 sintomas
🫁
Pulmão
4 sintomas
🫘
Rins
4 sintomas
🧬
Pele e cabelo
4 sintomas

+ 37 sintomas em outras categorias

Características mais comuns

55%prev.
Aumento do nível circulante de IgG
Frequente (79-30%)
55%prev.
Febre
Frequente (79-30%)
55%prev.
Aumento do nível circulante de IgM
Frequente (79-30%)
55%prev.
Pneumonia
Frequente (79-30%)
55%prev.
Imunodeficiência
Frequente (79-30%)
17%prev.
Hemoptise
Ocasional (29-5%)
76sintomas
Frequente (5)
Ocasional (34)
Muito raro (37)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 76 características clínicas mais associadas, ordenadas por frequência.

Aumento do nível circulante de IgGIncreased circulating IgG level
Frequente (79-30%)55%
FebreFever
Frequente (79-30%)55%
Aumento do nível circulante de IgMIncreased circulating IgM level
Frequente (79-30%)55%
Pneumonia
Frequente (79-30%)55%
ImunodeficiênciaImmunodeficiency
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico3.234PubMed
Últimos 10 anos200publicações
Pico2025127 papers
Linha do tempo
2026Hoje · 2026🧪 1977Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
2Fase 23
1Fase 11
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 9 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Coccidioidomicose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

101 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.036 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.036

#1

Variation in Management of Children With Coccidioidomycosis.

Pediatrics2026 Mar 13

Coccidioidomycosis (CM) is not as well described in children as it is in adults. The Kaiser Permanente Southern California (KPSC) system provides care within an endemic region for CM, affording the opportunity to describe the diagnosis, management, and outcomes of CM in a large pediatric cohort. This study is a retrospective manual medical record review of patients aged 17 years or younger with a new diagnosis of CM between January 1, 2015, and December 31, 2021. We extracted demographic characteristics, symptoms, diagnostic testing, and details of patient management. CM was identified in 209 patients. The incidence was 3.3 cases per 100 000 children but varied within the area covered by KPSC. Common symptoms were fever, cough, and rash (>59% for each). Disseminated CM was present in 10 patients (4.8%). Of the 199 patients without disseminated infections, 57 were observed without antifungal treatment; 1 (1.2%) eventually required treatment. For the remaining 142 patients treated with antifungals, the median duration of treatment was 150 days (ranging from <3 months to >2 years). After stopping treatment, 3 (2.1%) had recurrence. Recurrence was identified primarily based on symptoms rather than serologic testing, and all responded well to treatment. Wide clinician variability in the management of pediatric coccidioidomycosis was observed. Recurrence after treatment or failure of observation without antifungals was rare. Results from serologic testing outside of the initial diagnosis in asymptomatic patients typically did not change clinical management, while symptomatic follow-up was important for management.

#2

Exhausted T cell phenotypes in disseminated coccidioidomycosis.

medRxiv : the preprint server for health sciences2026 Feb 03

Coccidioidomycosis presents clinically as a spectrum ranging from self-limiting Uncomplicated Valley Fever (UVF) in most cases to life-threatening Disseminated Coccidioidomycosis (DCM) in rare individuals. A few patterns of immunologic deficits allowing for dissemination have been identified, though the specific defects in most individuals with DCM remain undefined. We hypothesized that chronic antigen exposure in DCM engenders a state of T cell exhaustion. From a cohort of over 300 subjects with confirmed diagnoses of coccidioidomycosis, circulating T cell phenotypes were characterized via flow cytometry and Coccidioides-specific T cell responses were measured using the Activation-Induced Marker (AIM) assay. Male sex was significantly associated with disseminated disease (odds ratio 2.5; 95% CI: 1.5 - 4.0). 52% of subjects showed Coccidioides-specific T cell responses in our AIM assay. We noted a significant difference in subjects sampled in the first year of diagnosis, where only 8% of DCM subjects had T cell responses during this time, as compared to 44% of UVF subjects (p = 0.04). Among DCM patients with detectable AIM responses, CD4+ T cells demonstrated an exhausted phenotype with elevated PD-1 expression compared to UVF subjects. In vitro PD-1 blockade augmented IFNγ production in most tested DCM subjects. These findings suggest that dissemination may occur in some individuals during a period of impaired antigen-specific T-cell activity. Importantly, these responses can be augmented in vitro by PD-1 blocking antibodies, supporting further study of immune checkpoint therapy as an adjunct to antifungal treatment in disseminated coccidioidomycosis.

#3

Coccidioidomycosis in cirrhosis: A high-risk syndrome with severe outcomes.

The American journal of the medical sciences2026 Jan 22

Patients with cirrhosis and end-stage liver disease (ESLD) are highly susceptible to severe infections due to cirrhosis-associated immune dysfunction (CAID). The clinical features and outcomes of coccidioidomycosis in this population remain poorly described. We conducted a retrospective cohort study of adults with cirrhosis and/or ESLD diagnosed with coccidioidomycosis between 2010 and 2025 at a tertiary referral center in California's San Joaquin Valley. Demographics, clinical features, diagnostics, management, and outcomes were abstracted from electronic health records. Forty-six patients met inclusion criteria. The mean age was 52 years, 74% were male, and 67% identified as Hispanic. Alcohol-related liver disease was the most common etiology, and 67% had decompensated cirrhosis. Respiratory symptoms predominated, with cough, dyspnea, and fever most frequent; 96% had abnormal chest imaging, most commonly diffuse infiltrates. Disseminated or complicated pulmonary disease occurred in 35%. Median diagnostic delay was 28 days. Antifungal therapy was given to 89% (primarily fluconazole); hepatotoxicity occurred in 26%. Hospitalization was required in 63%, ICU care in 24%, and relapse occurred in 24%. All-cause mortality was 33%, with a median time-to-death of 369 days. Coccidioidomycosis in cirrhosis represents a high-risk clinical syndrome marked by delayed diagnosis, high rates of hospitalization, treatment complications, and significant mortality. Early recognition and optimized anti-fungal management are urgently needed, and prospective studies should define best practices for this vulnerable population.

#4

Blastomycosis, Histoplasmosis, and Coccidioidomycosis in Outpatient Community-Acquired Pneumonia.

JAMA network open2026 Jan 02

Laboratory testing is necessary to distinguish blastomycosis, coccidioidomycosis, or histoplasmosis from other causes of community-acquired pneumonia (CAP). Robust data about testing for and diagnosis of these fungal diseases among patients with CAP throughout the US are lacking. To examine proportions and characteristics of (1) adult outpatients with CAP who underwent diagnostic testing for blastomycosis, coccidioidomycosis, or histoplasmosis; and (2) tested patients who received diagnoses of these diseases. This retrospective cohort study used 2017 to 2023 commercial health insurance claims data from the Merative MarketScan Commercial/Medicare Database. Adult outpatients with diagnosis codes for unspecified CAP were included. The primary outcome was the proportion of patients who underwent fungal diagnostic testing. The secondary outcomes were the proportions of tested patients who received diagnoses of blastomycosis, coccidioidomycosis, or histoplasmosis. Multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) for characteristics independently associated with receiving a diagnosis of coccidioidomycosis or histoplasmosis. Among 573 994 patients (318 152 female [55%]; median [IQR] age, 54 [41-63] years) with unspecified CAP, 25 822 (5%) underwent fungal diagnostic testing, which occurred a median (IQR) of 3 (1-6) health care visits after the initial CAP diagnosis. Among tested patients, 755 (3%) received a blastomycosis, coccidioidomycosis, or histoplasmosis diagnosis code. Rash (aOR, 3.24; 95% CI, 2.27-4.63), lymphadenopathy (aOR, 1.74; 95% CI, 1.15-2.63), myalgia (aOR, 1.66; 95% CI, 1.11-2.49), chest pain (aOR, 1.65; 95% CI, 1.35-2.02), and receipt of antibiotics from multiple classes (aOR, 1.40; 95% CI, 1.17-1.67) were independently associated with increased odds of receiving a coccidioidomycosis diagnosis. Autoimmune inflammatory disease (aOR, 3.00; 95% CI, 1.72-5.21), chest pain (aOR, 1.84; 95% CI, 1.20-2.82), and abnormal weight loss (aOR, 5.15; 95% CI, 2.71-9.79) were associated with increased odds of receiving a histoplasmosis diagnosis. In this cohort study of patients with unspecified CAP, testing rates for blastomycosis, coccidioidomycosis, and histoplasmosis were low in many locations. Increased awareness of these fungal infections may help increase timely testing for fungal diseases among patients with CAP, decrease health care utilization and inappropriate antibiotic use, and improve patient outcomes.

#5

Peritoneal Coccidioidomycosis.

The New England journal of medicine2026 Feb 19

Publicações recentes

Ver todas no PubMed

📚 EuropePMC2.199 artigos no totalmostrando 197

2026

The ascending trend of valley fever in El Paso, Texas and its association with regional meteorological and dust factors.

International journal of biometeorology
2025

Active fungal infections alter the respiratory microbiome profiles of Mayo Clinic Arizona patients.

Frontiers in microbiomes
2026

Osteoarticular Coccidioidomycosis in California: A Single-Center Experience.

Open forum infectious diseases
2026

Variation in Management of Children With Coccidioidomycosis.

Pediatrics
2026

Rising Burden of Severe Pediatric Coccidioidomycosis: A 25-Year Single Center Study.

Journal of the Pediatric Infectious Diseases Society
2026

Clinical evaluation of CTS-1 specific coccidioidal immunodiffusion reagents for improved sensitivity and enhanced agreement with complement fixation testing.

Clinical biochemistry
2026

Regional increases in incidence of coccidioidomycosis (Valley fever)-Arizona, 2005-2022.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2026

Immunomodulation in Disseminated Coccidioidomycosis: A Small Step or a Giant Leap?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Immunomodulation in the Treatment of Disseminated Coccidioidomycosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Primary Cutaneous Coccidioidomycosis Presenting on the Leg of an Immunocompetent Patient: A Case Report.

Case reports in infectious diseases
2026

Frequency, Timing, and Patient Factors Associated with Recurrence of Disseminated Cutaneous Coccidioidomycosis.

Journal of fungi (Basel, Switzerland)
2026

Dual Burden: Osteomyelitis Secondary to Disseminated Coccidioidomycosis in an Immunocompetent Patient.

Cureus
2026

A treatment monitoring protocol to determine clinical remission in dogs with pulmonary coccidioidomycosis.

Journal of veterinary internal medicine
2026

Use of Epoetin Alfa for Anemia of Chronic Disease in a Jehovah's Witness Teenager With Disseminated Coccidioidomycosis: A Case Report.

Cureus
2026

Pretransplant serologic testing for fungal infections in a large commercial health insurance database, United States.

Medical mycology
2026

Hypothesis on the dust-borne atmospheric transport of Coccidioides, causative fungal pathogen for coccidioidomycosis (Valley fever).

Medical mycology
2026

Amphotericin B Formulation Selection During Veno-Venous Extracorporeal Membrane Oxygenation: Two Case Reports Illustrating Clinical Dilemmas in the Absence of Data.

Hospital pharmacy
2026

Polymerase chain reaction may not be useful to detect Coccidioides spp DNA in oropharyngeal, nasal, or conjunctival swab samples in dogs with newly diagnosed pulmonary coccidioidomycosis.

American journal of veterinary research
2026

Regional Increases in Incidence of Coccidioidomycosis (Valley Fever) - Arizona, 2005-2022.

MMWR. Morbidity and mortality weekly report
2026

Coccidioidomycosis Masquerading as Malignancy: A Case of Mediastinal Mass and Pericardial Effusion in an Immunocompetent Jamaican Male.

Case reports in infectious diseases
2026

Peritoneal Coccidioidomycosis.

The New England journal of medicine
2026

Killing of Coccidioides by drugs.

Microbiology (Reading, England)
2026

Exhausted T cell phenotypes in disseminated coccidioidomycosis.

medRxiv : the preprint server for health sciences
2026

Atypical Panuveitis in Disseminated Coccidioidomycosis.

Retinal cases &amp; brief reports
2026

Immunocompetent host and mortality-related coccidioidomycosis: A case report and narrative review.

Medical mycology case reports
2026

Mixed mycotic infection in an immunocompromised host with advanced HIV diagnosed with the assistance of a Karius test.

Medical mycology case reports
2026

Coccidioidomycosis in an Immunocompetent Man.

The American surgeon
2026

Urban soils along the Kern River and Los Gatos Creek are hotspots for Coccidioides in the San Joaquin Valley of California.

bioRxiv : the preprint server for biology
2026

Simultaneous Liver and Kidney Transplantation for Cirrhosis Directly Attributed to Disseminated Hepatic Coccidioidomycosis.

Transplantation proceedings
2026

Hybrid histidine kinases and antifungal warfare in thermal dimorphic fungi.

Antimicrobial agents and chemotherapy
2026

Multisystemic Imaging Features of Coccidioidomycosis.

Radiographics : a review publication of the Radiological Society of North America, Inc
2025

Characterization of the first patient with disseminated coccidioidomycosis and autosomal dominant STAT1 deficiency.

Journal of human immunity
2026

Travel associated human coccidioidomycosis in Germany 2011-2023.

International journal of medical microbiology : IJMM
2026

Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis.

Clinical chemistry
2026

The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused by Coccidioides immitis.

Antimicrobial agents and chemotherapy
2026

Isolated knee septic arthritis revealing disseminated coccidioidomycosis without apparent pulmonary involvement: A case report.

Medical mycology case reports
2026

Coccidioidomycosis in cirrhosis: A high-risk syndrome with severe outcomes.

The American journal of the medical sciences
2025

Persistence of Symptoms among Commercially Insured Patients with Coccidioidomycosis, United States, 2017-2023.

Emerging infectious diseases
2026

Valley Fever in Central California: Diagnosis is Not the Finish Line, the Real Gap is Longitudinal Care.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Blastomycosis, Histoplasmosis, and Coccidioidomycosis in Outpatient Community-Acquired Pneumonia.

JAMA network open
2026

Coccidioidomycosis: an emerging disease in Taiwan.

Journal of the Formosan Medical Association = Taiwan yi zhi
2026

Primary cutaneous blastomycosis in a Chinese-Canadian girl following an insect bite.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Community-Level Health and Socioeconomic Disparities in Coccidioidomycosis: Insights from the Social Deprivation and Healthy Places Indices.

Medical mycology
2026

Choice of Downscaled Climate Product Matters: Projections of Valley Fever Seasonality in a Warming Climate.

GeoHealth
2026

Disseminated Coccidioidomycosis With Central Nervous System, Oropharyngeal, Pulmonary, and Cutaneous Involvement.

Mayo Clinic proceedings
2026

Linking the epidemiology of coccidioidomycosis and environmental exposure through targeted genomic enrichment of Coccidioides posadasii.

mBio
2026

Morphological and genetic characterization of novel Sarocladium spinificis strains in association with Coccidioides posadasii.

Microbiology spectrum
2025

Drug Discovery and Repurposing for Coccidioides: A Systematic Review.

Journal of fungi (Basel, Switzerland)
2025

Disseminated coccidioidomycosis with cutaneous, pulmonary and suspected CNS involvement in an elderly patient with Parkinson's disease.

BMJ case reports
2025

Disseminated peritoneal coccidioidomycosis mimicking malignancy in an immunosuppressed patient: a case report.

Journal of surgical case reports
2026

Clinical characteristics of seven dimorphic mycoses between 2015 and 2025 using a large global database.

Journal of infection and public health
2025

A Dermoscopic Great Imitator: Primary Cutaneous Coccidioidomycosis.

International journal of dermatology
2025

Common and Uncommon Imaging Manifestations of Thoracic and Disseminated Coccidioidomycosis Infection.

Radiology. Cardiothoracic imaging
2025

Trends in the epidemiology of systemic endemic mycoses in Latin America.

Medical mycology
2025

Effects of Soil Moisture and Soil Temperature on Coccidioidomycosis.

GeoHealth
2026

Current perspectives of host-pathogen dynamics in coccidioidomycosis.

Current opinion in microbiology
2025

Diagnostic Performance of Coccidioidomycosis PCR Testing in Lung Nodules: A Retrospective Study in Central California.

Journal of fungi (Basel, Switzerland)
2025

Coccidioidomycosis-Attributable Death in the United States: An Analysis of Cases Reported on Death Certificates, 2018-2023.

Journal of fungi (Basel, Switzerland)
2026

Chronic pulmonary coccidioidomycosis complicated with meningitis: A case report.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2025

A scalp to make you squirm: Cutaneous myiasis hiding a unique presentation of disseminated coccidioidomycosis.

IDCases
2025

Use of Intrathecal Amphotericin for Coccidioidal Meningitis.

Open forum infectious diseases
2025

Coccidioidomycosis-Associated Hospitalizations, United States, 2016-2021.

Open forum infectious diseases
2025

A Case of Reactivated Disseminated Coccidioidomycosis in an Elderly Patient.

Cureus
2025

Insights into current coccidioidomycosis therapeutic pathways.

Antimicrobial agents and chemotherapy
2026

IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

When should coccidioidomycosis be in the differential?

ASM case reports
2025

Pulmonary infection due to Balamuthia mandrillaris in the southwestern United States: not all miliary disease is tuberculosis and coccidioidomycosis.

ASM case reports
2025

A case of delayed diagnosis of disseminated coccidioidomycosis highlights opportunities for improved awareness.

ASM case reports
2025

Fungal vaccines: so needed, so feasible, and yet so far off.

The Journal of clinical investigation
2026

Disseminated coccidioidomycosis mimicking malignant lymphoma in a 14-year-old female.

Pathologie (Heidelberg, Germany)
2025

Intravenous Liposomal Amphotericin as an Adjunct to Fluconazole in Pediatric Patients With Central Nervous System Coccidioidomycosis: A Single-Center Case Series.

Journal of the Pediatric Infectious Diseases Society
2026

Coccidioidomycosis in Europe: a systematic literature review of epidemiology, treatment and outcomes.

The Journal of antimicrobial chemotherapy
2025

A Case of Coccidioides Meningitis in an Immunocompetent Host and the Challenges in Diagnosis.

Case reports in infectious diseases
2025

A case displaying the importance of JAK1 and JAK2 gene transcription in antifungal defense against coccidioidomycosis.

Frontiers in medicine
2025

Development and Optimization of Multi-Well Colorimetric Assays for Growth of Coccidioides posadasii Spherules and Their Application in Large-Scale Screening.

Journal of fungi (Basel, Switzerland)
2025

Pediatric Coccidioidal Meningitis: A Systematic Review and Proportional Synthesis of Cases Reported in the Fluconazole Era (2000-2025).

Journal of fungi (Basel, Switzerland)
2025

Solitary thalamic abscess without meningitis from Coccidioides immitis: illustrative case.

Journal of neurosurgery. Case lessons
2025

Mapping the Geographic Distribution of Dimorphic Mycoses Using a US Commercial Insurance Database.

Open forum infectious diseases
2025

Coccidioides genomes from low-incidence states reveal complex migration history across the western United States.

Microbiology spectrum
2025

Misuse of the unspecified coccidioidomycosis diagnosis code: An audit of electronic health records.

Medical mycology
2025

Single-cell analysis of human airway epithelium identifies cell-type-specific responses to Aspergillus and Coccidioides.

mBio
2025

Endoglucanase 2 (Eng2), a shared immunodominant antigen in dimorphic fungi that elicits immunity during infection.

The Journal of clinical investigation
2025

Cardiac MRI in Identifying Myopericarditis Mimicking STEMI in a Patient with HIV: A Case Report.

The American journal of case reports
2025

Disseminated Skeletal Coccidioidomycosis: A Case Report and Comprehensive Review.

Cureus
2025

Type-2 immune skewing in patients with disseminated coccidioidomycosis.

medRxiv : the preprint server for health sciences
2025

Mapping the environmental risk of coccidioidomycosis in Sonora, Mexico: a Bayesian spatiotemporal perspective (2010-2022).

International journal of environmental health research
2025

Cutaneous Coccidioidomycosis Mimicking Rosacea in Immunosuppressed Patient, Arizona, USA, 2024.

Emerging infectious diseases
2025

The Use of Genetics and Immunology in the Diagnosis and Care of Advanced Coccidioidomycosis: Where Are We Going?

Journal of fungi (Basel, Switzerland)
2025

First Reports of Canine Coccidioidomycosis in the Paso del Norte Region, Mexico-USA: A 10-Case Series.

Veterinary medicine and science
2025

Systemic endemic mycoses: From a geographical risk to a concern expansion.

Revista iberoamericana de micologia
2025

Real-world performance of diagnostic testing for coccidioidal meningitis in initial sampling of the cerebrospinal fluid.

Medical mycology
2025

Valley Fever Is an Occupational Illness: Let's Get the Data to Prevent It.

American journal of industrial medicine
2025

Dancing with the Dust Devil: Examining the Lung Mycobiome of Sonoran Desert Wild Mammals and the Effect of Coccidioides Presence.

Pathogens (Basel, Switzerland)
2025

Impact of Delays in Diagnosis on Healthcare Costs Associated With Blastomycosis, Coccidioidomycosis, and Histoplasmosis in a Commercially Insured Population.

Open forum infectious diseases
2025

Development of a Mouse Model of Coccidioidomycosis Using an Inhalation Exposure System.

Journal of fungi (Basel, Switzerland)
2025

The costs of the diagnosis and treatment of canine coccidioidomycosis in endemic regions, USA, 2022.

Preventive veterinary medicine
2025

The impact of bioinformatic choices on Coccidioides variant identification accuracy.

Microbiology spectrum
2025

A rare case of severe bilateral chorioretinal coccidioidomycosis in an immunocompromised pediatric patient with Takayasu Arteritis.

American journal of ophthalmology case reports
2025

Disseminated Musculoskeletal Coccidioidomycosis in an Immunocompetent Host: A Rare Case Requiring Extensive Spinal and Pelvic Surgery.

Cureus
2025

Disseminated Blastomycosis: A Case of Multisite Infection in an Immunocompetent Patient.

The American journal of case reports
2025

Man With Leg Mass, Fever, and Numbness.

Journal of the American College of Emergency Physicians open
2025

Comparison of Patients With Coccidioidomycosis in Arizona Versus California: A Commercial Health Insurance Claims Analysis.

Open forum infectious diseases
2025

Early immune response to Coccidioides is characterized by robust neutrophil and fibrotic macrophage recruitment and differentiation.

Microbiology spectrum
2025

Sweet Syndrome and Valley Fever: A Case Report.

Journal of the American College of Emergency Physicians open
2026

First documented case of primary cutaneous coccidioidomycosis in Taiwan.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
2025

"Select and Resequence" Methods Enable a Genome-Wide Association Study of the Dimorphic Human Fungal Pathogen Coccidioides posadasii.

Genome biology and evolution
2025

Coccidioidomycosis Lymphadenitis in a patient with lupus nephritis: a case report.

Journal de mycologie medicale
2025

The impact of osteoarticular invasion by Coccidioides Sp disseminated infection.

Medical mycology case reports
2025

The Epidemiology of Coccidioidomycosis (Valley fever) and the Disease Ecology of Coccidioides spp. in New Mexico (2006-2023).

Pathogens (Basel, Switzerland)
2025

Diagnosis and management of cutaneous infections in immunocompromised hosts part I: cellular immunodeficiency.

Journal of the American Academy of Dermatology
2025

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.

The Lancet. Infectious diseases
2025

Pearls and Pitfalls of Intrathecal Amphotericin B Therapy for Refractory Coccidioidal Meningitis in Children: An Illustrative Pediatric Case Series.

The Pediatric infectious disease journal
2025

Vertebral Coccidioidomycosis With Craniocervical Junction Instability and Ventral Displacement of C1 in a Pregnant Woman: A Case Report and Literature Review.

Cureus
2025

Coccidioides Fungemia in Central California: A 10-Years Experience.

Mycopathologia
2025

Pharmacokinetics of nikkomycin Z following multiple doses in healthy subjects.

Antimicrobial agents and chemotherapy
2025

Recall interferon-γ responses against Coccidioides are a surrogate marker for vaccine response in dogs.

American journal of veterinary research
2025

Estimated Burden of Coccidioidomycosis.

JAMA network open
2025

A cautionary tale of false-positive histoplasma urine antigen in an HIV patient: a case report.

Access microbiology
2025

Fluconazole-induced drug rash with eosinophilia and systemic symptoms syndrome: a case report.

Journal of medical case reports
2026

Interferon-γ Therapy in Patients With Refractory Disseminated Coccidioidomycosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Pulmonary Coccidioidomycosis Occurring in a Patient Treated With Acalabrutinib for Chronic Lymphocytic Leukemia.

Cureus
2025

Wildfire-Related Air Pollution and Infectious Diseases: Systematic Review and Meta-Analysis.

ACS environmental Au
2025

Fever of unknown origin: Unravelling the mystery of Q fever and coccidioidomycosis coinfection - Case report.

IDCases
2025

Detection of Airborne Coccidioides Spores Using Lightweight Portable Air Samplers Affixed to Uncrewed Aircraft Systems in California's Central Valley.

Environmental science &amp; technology letters
2025

Three in One: A Case Report of Pulmonary Co-infection With a Virus, a Bacterium, and a Fungus in an Immunocompetent Adult.

Cureus
2025

Child Organ Offer Process (cOOPS): Understanding Infectious Risk Assessment and Mitigation Strategies.

Pediatric transplantation
2025

Pulmonary Coccidioidomycosis in a Ruxolitinib-Treated Polycythemia Vera Patient: A Case Study and Literature Review.

Cureus
2025

Concurrent Coccidioidomycosis and Mycobacterium abscessus Infection in Chronic Obstructive Pulmonary Disease.

Journal of investigative medicine high impact case reports
2025

Characterizing the Soil Microbial Community Associated with the Fungal Pathogen Coccidioides immitis.

Journal of fungi (Basel, Switzerland)
2025

Using pet insurance claims to predict occurrence of vector-borne and zoonotic disease in humans in the United States.

Scientific reports
2025

Notes from the Field: Assessment of Awareness, Use, and Access Barriers to Cooling Centers in Maricopa County, Arizona - August 1-September 15, 2023.

MMWR. Morbidity and mortality weekly report
2025

Disseminated Coccidioidomycosis With Extensive Soft Tissue Abscesses in an Immunocompetent Male.

The American journal of medicine
2025

Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California.

Medical mycology
2025

Disseminated coccidioidomycosis presenting as eosinophilic ascites.

BMJ case reports
2025

Transcriptomic atlas throughout Coccidioides development reveals key phase-enriched transcripts of this important fungal pathogen.

PLoS biology
2025

Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis: A One Health Approach.

The Journal of infectious diseases
2025

A Unique Case of Disseminated Cutaneous Coccidioidomycosis Years After Initial Infection.

Cureus
2025

Discovery of novel antifungal drugs via screening repurposing libraries against Coccidioides posadasii spherule initials.

mBio
2025

Recent and Forecasted Increases in Coccidioidomycosis Incidence Linked to Hydroclimatic Swings, California, USA.

Emerging infectious diseases
2025

Identification of Coccidioidomycosis Immunoreactive Peptides That Recall T-Cell Responses Indicating Past Exposure.

The Journal of infectious diseases
2025

Coccidioidomycosis: a growing global concern.

The Journal of antimicrobial chemotherapy
2025

Fungal Infections Associated With TNF-Inhibitors: A 20-Year of a Systematic Review Fungal Infections and TNF-Inhibitors.

Mycoses
2025

Cavitary Pneumonia Causes in the Arid Landscapes of Southern Arizona.

American journal of medicine open
2025

Ex vivo coccidioidal antigen chitinase-1 stimulation increases production of interleukin-1β in healthy cats.

American journal of veterinary research
2025

Convergence Retraction Nystagmus Secondary to Central Nervous System Disseminated Coccidioides Immitis Infection in a Dog.

Veterinary medicine and science
2025

Laryngeal Coccidioidomycosis Mimicking Squamous Cell Carcinoma.

Head and neck pathology
2025

Prolonged coccidioidomycosis transmission seasons in a warming California: a Markov state transition model of shifting disease dynamics.

Journal of the Royal Society, Interface
2025

The Burden of Hospital Illness Associated with Disseminated Versus Isolated Pulmonary Coccidioidomycosis in the United States.

Journal of fungi (Basel, Switzerland)
2025

Time series forecasting of Valley fever infection in Maricopa County, AZ using LSTM.

Lancet regional health. Americas
2025

Climate Change and Coccidioidomycosis.

JAMA
2025

Laryngeal Coccidioidomycosis: A Delayed Diagnosis With Consequences.

The Pediatric infectious disease journal
2025

Access to diagnostic testing for invasive fungal diseases and other opportunistic infections in Mexican health care centers caring for patients living with HIV.

BMC health services research
2025

Coccidioidomycosis Prophylaxis in Liver, Kidney, and Heart Transplant Recipients Residing in Endemic Areas Within the United States.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Investigating Asthma After Coccidioidomycosis Among Patients With Commercial Health Insurance, United States, 2017-2022.

Mycoses
2025

Antifungal therapy patterns, healthcare utilization, costs, and mortality in central nervous system and non-central nervous system disseminated coccidioidomycosis across the continuum-of-care.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2025

When to suspect and how properly early detect and treat patients with endemic mycoses.

Molecular aspects of medicine
2024

Combination of metagenomic next-generation sequencing and morphology for identifying Coccidioides immitis: a case report.

Frontiers in medicine
2025

Sensitivity of Coccidioides serologic tests among culture-proven coccidioidomycosis patients with hematological malignancy compared to a matched immunocompetent cohort.

Medical mycology
2025

The profound effect of diabetes mellitus control on outcomes of coccidioidomycosis.

Medical mycology
2025

Mistaken for migraine: Coccidioidal meningitis.

JAAPA : official journal of the American Academy of Physician Assistants
2026

Impact of Fluconazole on Outcomes of Patients With Primary Pulmonary Coccidioidomycosis: A Commercial Health Insurance Claims-based, Propensity Score Matched Analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2024

Immune Reconstitution Inflammatory Syndrome-Induced Thrombocytopenia in a Patient With HIV and Coccidioidomycosis.

Cureus
2025

Valley-Forecast: Forecasting Coccidioidomycosis incidence via enhanced LSTM models trained on comprehensive meteorological data.

Journal of biomedical informatics
2025

Imported Systemic Endemic Mycoses in Spain 1997-2021: An Analysis of a National Hospital Database.

Mycoses
2025

Outcomes of Coccidioides Seropositive Solid Organ Transplant Recipients After Self-discontinuation of Antifungal Prophylaxis: The EIA-IgM-only Conundrum.

Transplantation
2025

Antifungal Prophylaxis for Coccidioidomycosis: How Long Is Long Enough?

Transplantation
2025

Emergence of Coccidioides posadasii in an asymptomatic Ecuadorian patient with diabetes: A case report.

IDCases
2025

Estimating the Exposure-Response Relationship between Fine Mineral Dust Concentration and Coccidioidomycosis Incidence Using Speciated Particulate Matter Data: A Longitudinal Surveillance Study.

Environmental health perspectives
2025

Lightning Can Strike Twice: Management of an Infant With Anomalous Left Coronary Artery from the Pulmonary Artery Complicated by Coccidioidomycosis Infection.

World journal for pediatric &amp; congenital heart surgery
2025

Pulmonary coccidioidomycosis presenting as a fungal ball mimicking aspergilloma.

Medical mycology case reports
2024

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways.

Journal of visualized experiments : JoVE
2024

Nonoperative management for disseminated spinal blastomycosis with extensive lytic destruction in a 35-year-old male: illustrative case.

Journal of neurosurgery. Case lessons
2025

Confronting the Challenges of Prevention, Diagnosis, and Management of Donor-Derived Coccidioidomycosis.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides.

mSphere
2025

Development of a novel patient-reported outcome measure for disseminated coccidioidomycosis (valley fever).

The Journal of antimicrobial chemotherapy
2025

Managing Cavitary Coccidioidomycosis Expert Opinions for Improving Patient Outcomes.

Chest
2025

Progressive head tilt and vestibular ataxia in a 3-year-old Basenji mix.

Journal of the American Veterinary Medical Association
2024

Burden of Hospitalization for Coccidioidal Meningitis: An Analysis of the National Inpatient Sample, 2019-2021.

Open forum infectious diseases
2024

Coccidiomycosis: ankle septic arthritis with an extended incubation period requiring aggressive multidisciplinary surgical intervention.

BMJ case reports
2025

Spatiotemporal analysis of lung immune dynamics in lethal Coccidioides posadasii infection.

mBio
2025

Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013-2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity.

Antimicrobial agents and chemotherapy
2024

Clinical utility of pharmacogenomic testing for patients with coccidioidal meningitis.

Medical mycology
2024

Musculoskeletal manifestations of lower-extremity coccidioidomycosis: a case series.

Journal of bone and joint infection
2025

A rare case of coccidioidomycosis in Singapore and challenges faced with laboratory diagnosis in a non-endemic area.

Pathology
2024

Disseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.

Journal of medical case reports
2024

Pulmonary coccidioidomycosis in China: Case reports and literature review.

IDCases
2024

Prolonged dry seasons lengthen coccidioidomycosis transmission seasons: implications for a changing California.

medRxiv : the preprint server for health sciences
2024

A Single-center Experience of Coccidioides Meningitis in Immunocompetent Patients: Case Series and Literature Review.

Open forum infectious diseases
2026

COCCIDIOIDAL ENDOPHTHALMITIS SECONDARY TO COCCIDOIDES POSADASII: A RARE INFECTION IN HUMANS.

Retinal cases &amp; brief reports
2024

A rare case of peritoneal coccidioidomycosis.

JAAPA : official journal of the American Academy of Physician Assistants
2024

Overview of the Current Challenges in Pulmonary Coccidioidomycosis.

Journal of fungi (Basel, Switzerland)
2026

Chronic Disseminated Coccidioidomycosis Presenting as Infertility.

Journal of minimally invasive gynecology
2024

Suspected Acute Pulmonary Coccidioidomycosis in Traveler Returning to Switzerland from Peru.

Emerging infectious diseases
2024

Valley fever on the rise: How climate change is fueling a public health crisis.

New microbes and new infections
2024

Valley fever under a changing climate in the United States.

Environment international
2024

Extensive erythematous plaques of fungal origin in an overseas student: Cutaneous manifestation of coccidioidomycosis.

Medical mycology case reports
Ver todos os 2.199 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Variation in Management of Children With Coccidioidomycosis.
    Pediatrics· 2026· PMID 41819487mais citado
  2. Exhausted T cell phenotypes in disseminated coccidioidomycosis.
    medRxiv : the preprint server for health sciences· 2026· PMID 41674579mais citado
  3. Coccidioidomycosis in cirrhosis: A high-risk syndrome with severe outcomes.
    The American journal of the medical sciences· 2026· PMID 41580284mais citado
  4. Blastomycosis, Histoplasmosis, and Coccidioidomycosis in Outpatient Community-Acquired Pneumonia.
    JAMA network open· 2026· PMID 41533376mais citado
  5. Peritoneal Coccidioidomycosis.
    The New England journal of medicine· 2026· PMID 41707141mais citado
  6. Enhanced Detection of Coccidioides spp. Fungi from Environmental Samples Using Droplet Digital PCR.
    Emerg Infect Dis· 2026· PMID 41986936recente
  7. Spatial point pattern analysis of environmental effects on valley fever intensity in Phoenix, Arizona.
    Infect Dis Model· 2026· PMID 41971971recente
  8. Cervical, Mediastinal, and Pericardial Disseminated Coccidioidomycosis: The Importance of Source Control.
    Case Rep Infect Dis· 2026· PMID 41948397recente
  9. Coccidioides skin test performance and patterns of prior immunity to coccidioidomycosis among a large population of males entering California state prisons, 2015-2024: a population-based modelling study.
    Lancet Reg Health Am· 2026· PMID 41939729recente
  10. Mapping the Landscape of Endemic Mycoses in India: Insights From a Systematic Review of Reported Cases Spanning 6 Decades (1960-2025).
    Open Forum Infect Dis· 2026· PMID 41923891recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:228123(Orphanet)
  2. MONDO:0005706(MONDO)
  3. GARD:9525(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q868137(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Coccidioidomicose
Compêndio · Raras BR

Coccidioidomicose

ORPHA:228123 · MONDO:0005706
Prevalência
Unknown
Herança
Not applicable
CID-10
B38.0 · Coccidioidomicose pulmonar aguda
CID-11
Ensaios
2 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0009186
Repurposing
6 candidatos
flutrimazolesterol demethylase inhibitor
methylprednisoloneglucocorticoid receptor agonist
methylprednisolone-sodium-succinatemicrotubule inhibitor|tubulin polymerization inhibitor
+3 outros
EuropePMC
Wikidata
Wikipedia
Papers 10a
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