Peripartum management of caesarean delivery in type 2 von Willebrand disease.

Allele-selective disruption of pathogenic VWF variants in type 2 von Willebrand disease using CRISPR/Cas9.

Neuraxial labor analgesia in type 2N von Willebrand disease: a case report.

Genetic determinants of clinical variability in type 2 von Willebrand disease: bridging genotype and phenotype.

A phase 1, open-label study to assess the pharmacokinetics, safety, and tolerability of a single intravenous injection of efanesoctocog alfa in adults with type 2N or type 3 von Willebrand disease.

Comparative Analysis of Pure VWF and VWF/FVIII Complex in Orthopedic Surgery for Type 2B von Willebrand Disease.

Landscape and Spectrum of VWF Variants in Type 2 Von Willebrand Disease: Insights from a German Patient Cohort.

A rare case of type 2A von Willebrand disease with compound heterozygous mutation.

Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF.

Predicting the effects of single pathological mutations in hemophilia A and type 2N von Willebrand diseases using AlphaFold2-multimer and AlphaFold3.

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs.

Structure-resolved dynamics of type 2M von Willebrand disease.

Genetic variants, thrombocytopenia, and clinical phenotype of type 2B von Willebrand disease: a median 16-year follow-up study.

Neonatal Onset Type 2B von Willebrand Disease due to p.Arg1306Trp Variant: a Case Report and a Literature Review.

Type 2N von Willebrand disease: genotype drives different bleeding phenotypes and treatment needs.

Small intestinal angiodysplasia and hemorrhage associated with acquired von Willebrand syndrome type 2A secondary to multiple myeloma: Reversal after treatment with IRD regimen (a case report and a brief review of the literature).

Misdiagnosis of type 2B von Willebrand disease as immune thrombocytopenia in a thrombocytopenic patient.

A noncanonical splicing variant c.875-5 T > G in von Willebrand factor causes in-frame exon skipping and type 2A von Willebrand disease.

Type 2M/2A von Willebrand disease: a shared phenotype between type 2M and 2A.

Genetic variations of type 2 and type 3 von Willebrand diseases in Thailand.

Von Willebrand Factor (VWF) multiplex activity assay differentiation of type 1 von Willebrand Disease (VWD) and variant VWD.

Challenges in management of women with type 2B von Willebrand disease during pregnancy and postpartum: evidence from literature and data from International Registry and Physicians Survey- communication from the SSC of the ISTH: comment from Comerford et al.

Periprocedural management of type 2N von Willebrand disease with efanesoctocog alfa.

Laboratory Testing for von Willebrand Factor: Factor VIII Binding for the Diagnosis or Exclusion of Type 2N von Willebrand Disease: An Update.

2B or not 2B: art thou autoinhibitory?

Familial thrombocytopenia and platelet clumping: Clues to the diagnosis of type 2B von Willebrand disease.

von Willebrand factor neutralizing and non-neutralizing alloantibodies in 213 subjects with type 3 von Willebrand disease enrolled in 3WINTERS-IPS.

Challenges in the management of women with type 2B von Willebrand disease during pregnancy and the postpartum period: evidence from literature and data from an international registry and physicians' survey-communication from the Scientific and Standardization Committees of the International Society on Thrombosis and Haemostasis.

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain.

Seidizadeh O, Baronciani L, Pagliari MT, et al. Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2. Blood Adv. 2022; 6(13):4031-4040.

A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD.

Origin and timing of de novo variants implicated in type 2 von Willebrand disease.

Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates.

External Quality Assessment Data for Investigation of von Willebrand Disease: Focus on Relative Utility of Contemporary Functional von Willebrand Factor Assays. The United Kingdom National External Quality Assessment Scheme (UK NEQAS) Experience.

[Three cases of von Willebrand type 2B in children].

Management of a patient with acute myeloid leukaemia with a diagnosis of type 2 von Willebrand disease and a novel variant within the von Willebrand factor (VWF) gene.

Evaluating Performance of Contemporary and Historical von Willebrand Factor (VWF) Assays in the Laboratory Identification of von Willebrand Disease (VWD): The Australasian Experience.

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.

The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease.

Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2.

Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease.

Von Willebrand disease type 2M: Correlation between genotype and phenotype: Comment from Woods et al.

"Von Willebrand disease type 2M: Correlation between genotype and phenotype": Comment from Favaloro.

Von Willebrand disease type 2M: Correlation between genotype and phenotype: Reply to comment from Dr. Favaloro and to comment from Dr. Woods et al.

Laboratory assays of VWF activity and use of desmopressin trials in the diagnosis of VWD: a systematic review and meta-analysis.

The Lesson Learned from the New c.2547-1G > T Mutation Combined with p.R854Q: When a Type 2N Mutation Reveals a Quantitative von Willebrand Factor Defect.

The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse.

Parathyroid Adenoma in a Young Girl with Type 3 von Willebrand Disease: Comment on "Cancers in Patients with von Willebrand Disease".

Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative and quantitative VWF defects.

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD.

Type 2B von Willebrand Disease: Early Manifestation as Neonatal Thrombocytopenia.

Platelet clump visible to the naked eye in type 2B von Willebrand disease.

Von Willebrand disease type 2M: Correlation between genotype and phenotype.

Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module.

Type 2N VWD: Conclusions from the Spanish PCM-EVW-ES project.

Type 2A and 2M von Willebrand Disease: Differences in Phenotypic Parameters According to the Affected Domain by Disease-Causing Variants and Assessment of Pathophysiological Mechanisms.

ETV6-related thrombocytopenia associated with a transient decrease in von Willebrand factor.

[von Willebrand disease type 2B caused by gene mutation in a newborn].

Type 2B von Willebrand Disease in Pregnancy: A Systematic Literature Review.

Emicizumab improves thrombus formation of type 2A von willebrand disease under high shear condition.

Inhibitor development in patients with type 3 Von Willebrand disease, a comprehensive study on 99 Iranian patients.

Von Willebrand disease type 2N: An update.

Endothelial Function in Patients With Von Willebrand Disease.

2B or not 2B? A diagnosis of von Willebrand disease a lifetime of 86 years in the making.

Correcting dominant-negative von Willebrand disease.

Type 2N von Willebrand disease: Is it always a recessive trait?

Activated factor VIII-mimicking effect by emicizumab on thrombus formation in type 2N von Willebrand disease under high shear flow conditions.

Ex Vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small Interfering RNA.

Laboratory variability in the diagnosis of type 2 VWD variants.

In vivo modulation of a dominant-negative variant in mouse models of von Willebrand disease type 2A.

Of aortic valve and bleeding: Heyde's syndrome.

Are Iranian patients with von Willebrand disease type 2N properly differentiated from hemophilia A and do they receive appropriate treatment?

Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small-Interfering RNA.

Noncanonical type 2B von Willebrand disease associated with mutations in the VWF D'D3 and D4 domains.

Case Report: An Infant with Severe Thrombocytopenia Diagnosed with Type 2B von Willebrand Disease Due To a De Novo p.Val1316Met Mutation.

Atypical transient perivascular inflammation of the carotid artery (TIPIC) in a previously diagnosed VWD type 2 M.

Molecular and clinical profile of type 2 von Willebrand disease in Iran: a thirteen-year experience.

Reduced Activity of von Willebrand Factor after Flow-Diverting Stent Implantation for Intracranial Aneurysms: A Link to Acquired von Willebrand Disease?

Evaluation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system.

From Montreal to von Willebrand….

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.

Higher rates of bleeding and use of treatment products among young boys compared to girls with von Willebrand disease.

Identification of a missense mutation (p.Leu1733Pro) in the A3 domain of von Willebrand factor in a family with type 2M von Willebrand disease.

How I manage severe von Willebrand disease.

When age is truly only a number: late diagnosis of von Willebrand disease type 2B in a 61-year-old woman.

Bleeding Symptoms and von Willebrand Factor Levels: 30-Year Experience in a Tertiary Care Center.

Recombinant Von Willebrand factor concentrate in 2A Von Willebrand disease: comparison to plasma-derived Von Willebrand factor concentrate therapy.

Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear.

BMI is an important determinant of VWF and FVIII levels and bleeding phenotype in patients with von Willebrand disease.

Spontaneous recurrent intracranial haemorrhage in a woman with type 2B von Willebrand disease: A clinical case and a brief literature review.

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence.

Genetic variants of VWF gene in type 2 von Willebrand disease.

Case report of two siblings with type 2A von Willebrand disease involving a novel mutation within the calcium-binding site of the A2 domain of von Willebrand factor.

Identification of a homozygous missense mutation (p.Cys379Gly) in the D1 domain of von Willebrand factor propeptide in a family with type 2A (IIC) von Willebrand disease.

Differential diagnosis between type 2A and 2B von Willebrand disease in a child with a previously undescribed de novo mutation.

A novel type 2N VWF gene mutation: a case report.

ATP6V0A2-related cutis laxa in 10 novel patients: Focus on clinical variability and expansion of the phenotype.

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.

A case of inherited type 1 and type 2A von Willebrand disease confirmed by diagnostic exome sequencing.

Management of pregnancy complications in type 2N von Willebrand disease associated to a novel mutation.

The course of acquired von Willebrand syndrome during pregnancy among patients with essential thrombocytosis.

How I treat type 2B von Willebrand disease.

Is gingival bleeding a symptom of type 2 and 3 von Willebrand disease?

Advances in the diagnosis and treatment of Von Willebrand disease.

A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.

Type 2N von Willebrand disease: Characterization and diagnostic difficulties.

A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers.

Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease.

Type 2B von Willebrand disease with or without large multimers: A distinction of the two sides of the disorder is long overdue.

Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice.

Von Willebrand Disease type 2 in pregnancy - A critical clinical association.

Clinical and laboratory phenotype variability in type 2M von Willebrand disease.

Differential diagnosis of neonatal alloimmune thrombocytopenia: Type 2B von Willebrand disease.

[Detection and analysis of plasma VWF levels in healthy Chinese by automatic standardized assay].

von Willebrand disease type 2B.

Management of Type 2B von Willebrand Disease during Pregnancy.

Type 2B von Willebrand Disease: An Unusual Cause of Severe Neonatal Thrombocytopenia.

Phenotypic Parameters in Genotypically Selected Type 2B von Willebrand Disease Patients: A Large, Single-Center Experience Including a New Novel Mutation.

Diagnosing von Willebrand disease: genetic analysis.

Prolonged Bleeding in a 34-Year-Old Man following Oral Surgery.

The Von Willebrand Factor A1-Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype.

Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage.

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.

Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease.

Management of type 2b von Willebrand disease in the neonatal period.

Diagnostic Differentiation of von Willebrand Disease Types 1 and 2 by von Willebrand Factor Multimer Analysis and DDAVP Challenge Test.

Maxillary pseudotumor as initial manifestation of von Willebrand disease, type 2: report of a rare case and literature review-a commentary.

Platelet abnormalities in a family with von Willebrand disease type 2B (V1316M) and association with bleeding score.

Genotyping might help therapeutic decision-making in patients with von Willebrand disease type 2 B.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami.

Thrombocytopenia Pitfalls: Misdiagnosing Type 2B von Willebrand Disease as Ethylenediaminetetraacetic Acid-Dependent Pseudothrombocytopenia.

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.

Type 2M and Type 2A von Willebrand Disease: Similar but Different.

Type 2B von Willebrand Disease: A Matter of Plasma Plus Platelet Abnormality.

Type 2M von Willebrand disease - more often misidentified than correctly identified.

Baseline factor VIII plasma levels and age at first bleeding in patients with severe forms of von Willebrand disease.

A novel ELISA-based diagnosis of acquired von Willebrand disease with increased VWF proteolysis.

Acquired Type II von Willebrand Syndrome in Locally Advanced Bladder Cancer Successfully Treated With Intravenous Immunoglobulin and Chemotherapy.

The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIbα on the rate of cleavage to VWF by ADAMTS13.

A family having type 2B von Willebrand disease with a novel VWF p.R1308S mutation: Detection of characteristic platelet aggregates on peripheral blood smears as the key aspect of diagnosis.

Maxillary pseudotumor as initial manifestation of von Willebrand disease, type 2: report of a rare case and literature review.

Clinical phenotype in genetically confirmed von Willebrand disease type 2N patients reflects a haemophilia A phenotype.

Evaluation of an heterogeneous group of patients with von Willebrand disease using an assay alternative to ristocetin induced platelet agglutination.

First report of inhibitory von Willebrand factor alloantibodies in type 2B von Willebrand disease.

CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease.

von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo.

Spectrum of Von Willebrand's disease in Punjab: clinical features and types.

VWD type 2N (Normandy) in two sisters.