Equinococose alveolar

Treatment Trial of Alveolar Echinococcosis

NCT07182305

Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole

NCT02876146

Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles

NCT00658294

Long-term Results of Comprehensive AE Management

NCT02509884

NCT07182305 · Treatment Trial of Alveolar EchinococcosisConcluído

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NCT02876146 · Alveolar Echinococcosis: Parasite Viability and Innovative M…Concluído

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NCT00658294 · Analysis of the Potentially Parasitocidal Effect of a Long T…Concluído

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NCT02509884 · Long-term Results of Comprehensive AE ManagementConcluído

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Publicações mais relevantes

Timeline de publicações

1.148 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.148

#1

Detection of Echinococcus multilocularis in coyotes in Washington State, USA highlights need for increased wildlife surveillance.

PLoS neglected tropical diseases2026 Mar

Echinococcus multilocularis is a zoonotic cestode that uses canids as definitive hosts and rodents as intermediate hosts. In humans, this parasite is the causative agent of alveolar echinococcosis. Recently, its range has been expanding across the Northern Hemisphere, and it is increasingly detected in wild canids, domestic dogs, and humans across Canada and the United States. While this expansion has been documented in isolated studies across the continent, a lack of routine sampling in wildlife hinders our ability to anticipate and mitigate further spread of E. multilocularis. We confirmed the presence of E. multilocularis in Washington State, USA, using a combination of morphological and molecular techniques across carcasses and field-collected scats of coyotes (Canis latrans), this region's most common wild canid. Morphological identification of adult worms was confirmed by next-generation sequencing. Over a third of all samples tested positive for E. multilocularis when all methodologies were combined. Sequencing revealed a haplotype of E. multilocularis matching a documented haplotype originally of European origin in British Columbia, Canada. Our study provides the first confirmation of E. multilocularis in a wild host on the west coast of the contiguous United States and provides additional haplotype information crucial to tracking the geographical expansion of the parasite. We also provide a new next-generation sequencing primer targeting cestodes of canids. The difference in amplification between intestinal and fecal samples suggests that non-invasive fecal sampling using DNA metabarcoding - a popular method of helminth surveillance - may lead to underestimation of prevalence, hindering control measures. The global significance of these findings extends beyond North America; E. multilocularis is a major public health concern in Europe and Asia, where alveolar echinococcosis is increasingly diagnosed in humans. Our study highlights the urgent need for increased surveillance and improved diagnostic strategies worldwide, particularly in regions with significant human-wildlife contact.

#2

Canonical WNT signalling governs Echinococcus metacestode development.

PLoS pathogens2026 Mar 23

Alveolar echinococcosis (AE) is a lethal zoonosis caused by infiltrative growth of the metacestode larva of the tapeworm Echinococcus multilocularis in host organs. We previously showed that the Echinococcus metacestode is an evolutionarily unique, broadly posteriorized tissue, leading us to hypothesize that canonical WNT (cWNT) signalling, which patterns the body axis across metazoans, might be critical for metacestode formation. Here, we report effective RNAi-mediated knockdown of the E. multilocularis β-catenin gene (bcat-1), the central effector of cWNT signalling, in a primary parasite cell culture system that produces metacestode vesicles. bcat-1(RNAi) cultures were markedly impaired in vesicle formation, exhibited stem-cell hyperproliferation, and displayed changes in muscle-fibre organisation. Genome-wide transcriptomics revealed a general anteriorization of gene expression, and in situ hybridization showed an overproduction of cells expressing head-inducing factors such as sfrp upon bcat-1 knockdown. Conversely, metacestode-specific genes including the tegumental factors muc-1, TNFR, and antigen B as well as the posterior marker post2b were significantly downregulated, consistent with the observed vesicle-formation defects. In situ analyses further identified anterior markers frizzled-10, nou-darake, notum, and follistatin that were overexpressed in bcat-1(RNAi) cultures and localized to the future anterior pole at the earliest stages of protoscolex formation. Together, these findings establish a central role for cWNT signalling in directing Echinococcus body-axis formation and the posteriorization events driving metacestode growth within the host, providing insight into asexual parasite proliferation mediated by this biologically unique larval stage and pointing to potential targets for chemotherapy against AE.

#3

Burden of cystic and alveolar echinococcosis in the Kyrgyz Republic.

PLoS neglected tropical diseases2026 Mar 23

The purpose of this study is to assess some aspects of the burden of cystic and alveolar echinococcosis in the Kyrgyz Republic. From 2015-2020 a total of 5568 cases of primary cystic echinococcosis (CE) were reported and a further 1008 recurrent cases. Over the same time period 880 primary cases of primary alveolar echinococcosis (AE) were reported and a further 343 recurrent cases. The estimated DALYs for CE was 7849, that is 1308 per annum or 19.5 per 100,000 per annum. For AE was there were 3809 DALYs, that is 634 per annum or 9.5 per 100,000 per annum. The proportion of fatal cases of AE was 3.6 times higher than from CE. The total economic damage in terms of purchasing power equivalent (PPE) from CE amounted to more than 10,5 million international US dollars. For AE it amounted to more than 5.1 million international US dollars. Most of the financial burden falls on the patients themselves and amounts to 68.4%, i.e., 1223 PPE dollars per case out of total spending 1615 PPE dollars per case. To reduce the social and economic burden of echinococcosis, it is necessary to timely identify the disease, prevent the development of complications and multiple lesions, and promote preventive chemotherapy where appropriate. A deep understanding of the etiology, epidemiology, clinical manifestations, and tactics of early diagnosis of various forms of echinococcosis is also important for timely detection, effective control, and, most importantly, the organization of preventive measures to combat this disease.

#4

Population-based ultrasound prevalence and risk factors for cystic echinococcosis in endemic Kazakhstan.

PLoS neglected tropical diseases2026 Mar

Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu lato, remains a significant public health concern in endemic areas of Kazakhstan. Despite global control efforts, CE persists due to insufficient deworming of dogs, the absence of control programs, and low public awareness. A cross-sectional study was conducted between September 2023 and June 2024 in 51 remote villages across two endemic regions of Kazakhstan. Participants underwent abdominal ultrasound screening and completed a structured questionnaire to assess potential risk factors. Cyst staging was performed according to the WHO - Informal Working Group on Echinococcosis guidelines. Statistical analyses included both univariate and multivariate models to identify significant predictors of infection. The prevalence of CE was 0.34%, with higher rates observed in young people (82.1%) than in adults (17.9%), particularly among those aged 9-14 years. Major potential risk factors included dog ownership (OR = 3.17, p = 0.012), failure to deworm dogs (OR = 11.12, p = 0.018), feeding raw offal to dogs (OR = 3.06, p = 0.012), and consumption of unwashed vegetables and fruits among women (OR = 5.25, p = 0.005). All identified CE cases were newly diagnosed. Of these, 92.85% were active cysts, predominantly found in young individuals, while inactive cysts accounted for 7.14%, distributed equally between adults and youths. These findings underscore the urgent need for regular deworming programs for dogs, public education on hygiene practices, and stricter management of livestock offal. Further research is needed to investigate transmission through water and environmental contamination.

#5

A neuregulin-like ligand and EGF receptor underpin Echinococcus multilocularis development.

Frontiers in cellular and infection microbiology2026

Alveolar echinococcosis (AE), a neglected zoonotic disease, is caused by the infiltrative growth of the metacestode larval stage of the cestode Echinococcus multilocularis within host organs. We previously showed that metacestode development relies on the mitotic activity of a population of parasite stem cells known as germinative cells. However, the molecular mechanisms that control Echinococcus stem cell dynamics such as cell-cycle progression, self-renewal, and differentiation remain poorly understood. Building on earlier reports implicating epidermal growth factor (EGF) signalling in stem cell regulation, we here characterize the parasite's repertoire of three EGF receptors. Using RNAi and inhibitor assays, we identify one receptor, EmER1, as essential for the formation of metacestode vesicles from germinative cells. We further demonstrate that EmER1 is targeted by afatinib, an EGF receptor inhibitor with potent anti-parasitic activity both in vitro and in vivo. Through bioinformatic analyses and membrane-bound yeast two-hybrid assays, we identified a parasite-derived, neuregulin-like ligand for EmER1, termed EmNRG, whose expression is strongly upregulated in metacestode vesicles during clonal expansion of germinative cells. RNAi-mediated knockdown of the EmNRG encoding gene severely impaired the capacity of germinative cells to generate metacestode vesicles. Our data support that EmNRG and EmER1 constitute a cognate ligand - receptor system regulating the balance between asymmetric and symmetric stem cell division in E. multilocularis. These findings provide new insights into Echinococcus stem cell biology and highlight EGF signalling as a promising avenue for developing novel anti-echinococcosis therapeutics.

Publicações recentes

Primary spinal alveolar echinococcosis in a patient with liver cirrhosis and TIPS.

Rofo2026 Apr 16

Diagnostic pearls and pitfalls in the radiologic evaluation of hepatic alveolar echinococcosis.

Diagn Interv Radiol2026 Apr 13

Therapeutic effects of IL-33/ST-2 pathway inhibition combined with albendazole on hepatic fibrosis and immune regulation in alveolar echinococcosis: in vivo and in vitro evidence.

Parasit Vectors2026 Apr 3

Ver todas no PubMed

📚 EuropePMC1.294 artigos no totalmostrando 198

Detection of Echinococcus multilocularis in coyotes in Washington State, USA highlights need for increased wildlife surveillance.

Canonical WNT signalling governs Echinococcus metacestode development.

PLoS pathogens

Burden of cystic and alveolar echinococcosis in the Kyrgyz Republic.

Small particles of Echinococcus granulosus (spegs) and Echinococcus multilocularis (spems) promote follicular T helper cell expansion and are associated with IgE and IgG4 class switching in human lymph nodes.

Inflammatory exacerbation of hepatic alveolar echinococcosis during dupilumab therapy: A case report.

IDCases

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Analysis of Clinical, Imaging, and Pathological Features of Osseous Echinococcosis.

Population-based ultrasound prevalence and risk factors for cystic echinococcosis in endemic Kazakhstan.

A case of left adrenal echinococcosis misdiagnosed as a left renal cyst: Case report.

Medicine

A neuregulin-like ligand and EGF receptor underpin Echinococcus multilocularis development.

Alveolar echinococcosis drives functional reprogramming of hepatic CD8+ T cells.

CCR8 orchestrates an immunosuppressive niche in the liver to promote Echinococcus multilocularis infection.

Alveolar Echinococcosis in the Early 2020s: A Systematic Review.

Contrast-Enhanced Ultrasound Phenotypes in Hepatic Alveolar Echinococcosis: Pathological Correlations and Prediction of Vascular Invasion.

Academic radiology

International journal of surgery (London, England)

Transplantation as a treatment option for hepatic echinococcosis past, present, and future - a pooled data analysis of 476 patients.

Euro-Asian hybrids of Echinococcus multilocularis from red foxes in northern and northeastern Poland result from secondary contact between long-isolated populations.

Protoscolex Maturation in Echinococcus multilocularis Is Controlled by Host Genetic Factors Independent of Initial Development.

Parasite immunology

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

[Alveolar echinococcosis in a pregnant bitch - a case report].

LAG3 constrains anti-parasitic response by effector CD4+ T-cell in early Echinococcus multilocularis-infected mice.

International journal of surgery (London, England)

Surgical approaches for complex hepatic and perihepatic tumors: a single-center experience with ante situm and ex situ techniques.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

Preparation and MR Imaging Study of a Recombinant Surface Antibody Superparamagnetic Iron Oxide Nanoparticle-EPC1 Molecular Probe for Hepatic Alveolar Echinococcosis.

Revista da Sociedade Brasileira de Medicina Tropical

Hepatic Alveolar Echinococcosis Mimicking Hepatic Malignancy.

Revista da Sociedade Brasileira de Medicina Tropical

Diffuse Pericardial and Diaphragmatic Involvement of Alveolar Echinococcosis in a Liver-Transplanted Patient.

Revista da Sociedade Brasileira de Medicina Tropical

Primary Alveolar Echinococcosis of the Kidney.

Parasites, hosts and diseases

A fatal case of complex hepatic alveolar echinococcosis.

The American journal of tropical medicine and hygiene

A Multicenter Retrospective Study of Cystic and Alveolar Echinococcosis Patients in the United States (1997-2024).

Diagnosis and treatment of hepatic hilar lymph node metastasis in hepatic alveolar echinococcosis patients: a real-world single-center experience.

Frontiers in oncology

NPJ biofilms and microbiomes

The gut microbiota mediates depression-like behaviors in mice with chronic Echinococcus multilocularis infection.

International journal of biological macromolecules

Macrophage-derived S100A9 drives liver fibrosis in Echinococcus multilocularis infection by up-regulating secreted protein acidic and rich in cysteine (SPARC) in hepatic stellate cells.

Frontiers in bioscience (Landmark edition)

Exploring the Potential Role of Interleukin-33 in Inducing Eosinophil-Mediated Fibrosis in Hepatic Alveolar Echinococcosis.

Tapeworms in an Apex Predator: First Molecular Identification of Taenia krabbei and Taenia hydatigena in Wolves (Canis lupus) from Romania.

Journal of colloid and interface science

Core-shell heterostructured nanozyme for alveolar echinococcosis treatment via targeted electron transfer and catalytic reactive oxygen species generation.

International journal for parasitology

Analysis of Echinococcus multilocularis complete mitogenomes: evidence for the historical spread from Central Asia to the Northern Hemisphere.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Transformer-based multimodal fusion model predicts lymph node metastasis in hepatic alveolar echinococcosis patients: A multicenter study.

IL-22-STAT3-CD155 axis in alveolar echinococcosis: a pivotal role in immune exhaustion and therapeutic potential.

Enhancing the structural stability of P29-targeted monoclonal antibodies via β-hydroxybutyrylation modification improves their therapeutic performance in alveolar echinococcosis.

Infectious diseases of poverty

Diagnostic performance comparison of two ultrasound classification systems for hepatic alveolar echinococcosis: a single-center retrospective study.

Crystal structure of Echinococcus multilocularis cystatin B reveals a novel feature in classical stefins.

First report of Taenia arctos (Cestoda: Taeniidae) from brown bears (Ursus arctos) in Romania.

International journal for parasitology. Parasites and wildlife

Corrigendum to "Chasing intermediate hosts of Echinococcus multilocularis at the southern edge of its European distribution using red fox stomach content analysis" [Int. J. Parasitol. Parasite. Wildlife 27 (2025) 101095].

International multicentre study to validate the Segmental Sedimentation and Counting Technique (SSCT) for the surveillance of Echinococcus multilocularis in red fox.

Veterinary parasitology

Unmasking the mimic: vertebral alveolar echinococcosis diagnosed by metagenomic next-generation sequencing.

Infection

TPEDCC-PEG-based photodynamic therapy exhibits potent therapeutic efficacy against echinococcosis by inducing oxidative stress and mitochondria-mediated apoptosis.

Epidemiology and spatiotemporal patterns of human echinococcosis in China, 2006-2020.

Journal of helminthology

A retrospective study on the efficacy of ex vivo liver resection combined with autologous liver transplantation in treating advanced alveolar echinococcosis at high altitude.

BMC gastroenterology

Hepatobiliary & pancreatic diseases international : HBPD INT

Ex vivo liver resection and autotransplantation for hepatic alveolar echinococcosis with cavernous transformation of the portal vein.

Macroscopic and Microscopic Aspects of Echinococcus multilocularis and Echinococcus granulosus in Humans: A Guideline for Pathologists.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection.

Updating Clinical Management of Cystic and Alveolar Echinococcosis: Insights and Challenges.

Clinical, Diagnostical, and Epidemiological Findings at First Diagnosis of Alveolar Echinococcosis: A Single-Center Cohort Study.

Sectional Imaging for Alveolar Echinococcosis.

[The infectious liver tumour].

Praxis

The Lancet regional health. Western Pacific

Prioritizing interventions for echinococcosis prevention in China: a population attributable fraction analysis.

The impact of radical hepatectomy on prognosis of patients with hepatic alveolar echinococcosis complicated with microvascular invasion.

Frontiers in microbiology

Host angiogenic reprogramming by Echinococcus multilocularis protoscoleces protein via PDGFR/PI3K/AKT cascade.

Ultrasound-based population survey for abdominal cystic echinococcosis in Albania: Results from the NDTND project.

Nuklearmedizin. Nuclear medicine

Diagnosis of hepatic alveolar echinococcosis:18F-FDG-PET activity compared to the Echinococcus multilocularis Ulm Ultrasound Classification.

Mitochondrial Network Fragmentation Leads to Dysfunction of Macrophages During Echinococcus multilocularis Protoscoleces Infection.

Sonographic double patterns in hepatic alveolar echinococcosis according to the echinococcosis multilocularis ultrasound classification.

Parasitology research

Is a shortened postoperative albendazole duration after curative surgery for alveolar echinococcosis possible? Results from a prospective multicenter study.

In Vivo MicroRNA-Based Inhibition of Experimental Cestode Infection.

ACS infectious diseases

Osteopontin Promotes Liver Echinococcus multilocularis Growth and Invasion via p38MAPK Pathway.

Parasite immunology

Diagnostic and interventional radiology (Ankara, Turkey)

Hepatic alveolar echinococcosis: a great tumor mimicker.

Investigation of the Alterations in the Gut Microbiota and Intestinal Mucosa in Mice Infected with Echinococcus multilocularis.

Acta parasitologica

An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Effects of Abrus cantoniensis capsule on gut microbiota and intestinal barrier in mice infected with alveolar echinococcosis.

Analysis of four Echinococcus multilocularis mitogenome sequences from Inner Mongolia, China: supporting the hypothesis that E. sibiricensis is confirmed as the O1 haplotype.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Basal meningitis in a patient with hepatic alveolar echinococcosis.

The Great Pretender: Echinococcal Infections Posing as Liver Cancer - Two Case Reports.

Case reports in oncology

Profile of Cytokines TNFα, IL-1β, IL-6, IL-4, and IL-10 in Relation to Disease Progression in a Patient with Advanced Liver Alveolar Echinococcosis and Non-Optimal Antiparasitic Treatment: Four-Year Follow-Up.

Oxymatrine alleviates Echinococcus multilocularis infection by remodeling the liver immune microenvironment and intestinal flora homeostasis.

MicroRNA expression dynamics in mouse liver at different stages of Echinococcus multilocularis infection.

BMC genomics

Annals of hepato-biliary-pancreatic surgery

Hepatobiliary alveolar echinococcosis treated with delayed resection following percutaneous drainage.

International immunopharmacology

Targeted inhibition of METTL3 reprograms alveolar echinococcosis progression: attenuating ferroptosis by downregulating ACSL4 and reversing macrophage M2 polarization.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Genetic diversity of Echinococcus multilocularis from red foxes and humans in northern and northeastern Poland investigated using the microsatellite EmsB.

Travel medicine and infectious disease

Clinical application value of droplet digital PCR detection of Em-cfDNA in the diagnosis of hepatic alveolar echinococcosis.

The Role of Interventional Radiology for the Treatment of Liver CE and AE Lesions: Current Concepts.

Annals of nuclear medicine

Whole-body dynamic FDG-PET/CT parametric imaging in alveolar echinococcosis.

Przeglad epidemiologiczny

Human alveolar echinococcosis: consequences of discontinuation of albendazole treatment - a report of two cases.

The incidence rates of human and animal echinococcosis: A systematic review.

Open veterinary journal

World journal of gastroenterology

Identification of key factors and explainability analysis for surgical decision-making in hepatic alveolar echinococcosis assisted by machine learning.

Infectious diseases and therapy

Two Decades of Living with Echinococcus multilocularis: A Clinical Epidemiology Study on Human Alveolar Echinococcosis in Hungary.

Indian journal of thoracic and cardiovascular surgery

Pulmonary malignant tumor metastasis or alveolar echinococcosis metastasis: the radiological dilemma.

The American journal of case reports

Alveolar Echinococcosis Mimicking Perihilar Cholangiocarcinoma Leading to Liver Transplant: A Case Report.

Unexplained subcutaneous swelling: Keep echinococcosis in mind! Report of two primary extrahepatic subcutaneous echinococcosis cases and literature review.

Journal of clinical and translational hepatology

Heterotopic Auxiliary Liver Transplantation in a Child with Portal Hypertension Using a Discarded Partial Right Liver Allograft from an Adult Patient with Alveolar Echinococcosis.

Changing distribution, diversity, and health impact of Echinococcus multilocularis in Europe and North America: Comparison, connections, and opportunities.

Advances in parasitology

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

Efferocytosis-Driven M2 Macrophage Impairs Fibrotic Encapsulation and Promotes Echinococcus multilocularis Growth in Cotton Rats (Sigmodon hispidus).

International journal for parasitology. Drugs and drug resistance

In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis.

Indian journal of medical microbiology

Epidemiology and clinical characteristics of alveolar echinococcosis in India: A systematic review and individual participant data meta-analysis.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Epidemiological and clinical characteristics of patients in the alveolar echinococcosis registry, France, 1982 to 2021.

Polish archives of internal medicine

Alveolar echinococcosis of the adrenal gland: a rare diagnostic challenge among adrenal incidentalomas.

One health (Amsterdam, Netherlands)

An update on the prevalence of Echinococcus multilocularis in red foxes (Vulpes vulpes) in a Central European focus: Northern and northeastern Poland (2022-2024).

Community risk of environmental-borne cystic echinococcosis transmission in South America: Results from the multistep cross-sectional and case-control PERITAS study.

Spatiotemporal distribution of newly diagnosed echinococcosis patients in Sichuan Province, China, 2013-2024.

Cellular and molecular life sciences : CMLS

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host.

Transcriptomic Profiling Reveals Gene Expression Changes in Mouse Liver Tissue During Alveolar Echinococcosis.

Genes

HPB : the official journal of the International Hepato Pancreato Biliary Association

Reappraisal of the impact of resection margin on outcomes after hepatectomy and perioperative treatment for Alveolar echinococcosis a single center experience.

Infectious diseases of poverty

Clinical confirmation of an infection with Echinococcus multilocularis (Mongolian genotype): first case report of human alveolar echinococcosis in Inner Mongolia, China.

Comparative proteomic analysis of subcutaneous and intraperitoneal cysts of Echinococcus multilocularis.

Journal of proteomics

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A high-throughput LC-MS/MS method for simultaneous analysis of albendazole, albendazole sulfoxide and albendazole sulfone in human plasma.

Acta microbiologica et immunologica Hungarica

Acute peritoneal propagation of alveolar echinococcosis in a 12-year-old child.

Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic risks.

BMC veterinary research

Echinococcosis on the Tibetan Plateau, where to go?

Trends in parasitology

Journal of medical case reports

The initial stage of alveolar echinococcosis is a diagnostic challenge: a case report.

Frontiers in microbiology

CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model.

Indian journal of medical microbiology

First molecular confirmed patient of alveolar echinococcosis in India: Case report from a tertiary care hospital in North India.

TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection.

International journal for parasitology. Parasites and wildlife

Chasing intermediate hosts of Echinococcus multilocularis at the southern edge of its European distribution using red fox stomach content analysis.

International journal for parasitology. Parasites and wildlife

Parasite diversity in grey wolves (Canis lupus) from Tuscany, central Italy: a copromicroscopical investigation.

Molecular survey of taeniid cestodes with special emphasis on Echinococcus species in free-roaming dogs and wild carnivores in Armenia.

Parasitology

IDO1 promotes Echinococcus multilocularis infection by regulating the formation of neutrophil extracellular traps.

Veterinary research

World journal of gastrointestinal surgery

Simultaneous combined surgery for hepatic-renal double organ alveolar or cystic echinococcosis: A retrospective study.

International journal for parasitology. Parasites and wildlife

First detection of Echinococcus multilocularis in golden jackals (Canis aureus) in Bosnia and Herzegovina.

The Lancet. Infectious diseases

Unveiling the incidences and trends of alveolar echinococcosis in Europe: a systematic review from the KNOW-PATH project.

Preliminary Proteomic and Metabolomic Analyses Reveal Potential Serum Biomarkers for Identifying Alveolar Echinococcosis in Mice.

Veterinary sciences

EmsB Microsatellite Analysis of Echinococcus multilocularis Specimens Isolated from Belgian Patients with Alveolar Echinococcosis and from Animal Hosts.

The Lancet. Infectious diseases

First human infection and management of Versteria rafei infection restricted to the liver with phylogenetic analysis in the context of known cases.

Infectious diseases of poverty

Settlement characteristics and transmission of echinococcosis: a cross-sectional study in nomadic communities on the Qinghai-Tibet Plateau, China.

Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis.

Ultrasound Diagnostics in Alveolar Echinococcosis: An Update.

Alveolar Echinococcosis in 11-Month-Old Dog-Clinical Case.

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

[Proportions of memory T cells and expression of their associated cytokines in lymph nodes of mice infected with Echinococcus multilocularis].

Hepatic alveolar echinococcosis infection induces a decrease in NK cell function through high expression of NKG2A in patients.

Application of 11C-CHO in the imaging of cerebral alveolar echinococcosis: A prospective study.

Medicine

Polish archives of internal medicine

Human alveolar echinococcosis lesion in the right atrium mimicking a large cardiac thrombus.

The value of nomogram analysis in predicting pulmonary metastasis in hepatic alveolar echinococcosis.

Journal of imaging informatics in medicine

Two-Stage Automatic Liver Classification System Based on Deep Learning Approach Using CT Images.

Minimally Invasive Surgical Strategies for Alveolar Echinococcosis of the Liver.

Double Trouble on the Lower Leg-Unique Human Coinfection with Echinococcus granulosus and Echinococcus multilocularis Without Liver Involvement.

Echinococcus multilocularis Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Regulation of Host Regulatory T Cell Differentiation by emu-let-7-5p in Echinococcus multilocularis Infection Through Targeting NFκB2.

[Infectious cysts and pseudocysts: When parasites want to mimic tumors!].

Annales de pathologie

International immunopharmacology

Corrigendum to "Identification and exploration of a new M2 macrophage marker MTLN in alveolar echinococcosis" [International Immunopharmacology 131 (2024) 111808].

Emerging infectious diseases

Comprehensive Survival Analysis of Alveolar Echinococcosis Patients, University Hospital Zurich, Zurich, Switzerland, 1973-2022.

Hepatic alveolar echinococcosis with chest wall metastasis: a case report.

Frontiers in medicine

Transplantation proceedings

Echinococcal Liver Infections: Comparing Transplant Strategies for Granulosus and Alveolaris.

Polish archives of internal medicine

Alveolar echinococcosis in a patient diagnosed with liver tumor.

Alveolar Echinococcosis: Is Non-Radical Liver Resection a Game Changer in the Current Treatment Approach to Patients with Advanced Alveolar Echinococcosis Disease? Single Center Experience of Poland.

Acta parasitologica

Infection and drug resistance

Impact of Multimodal Fast-Track Protocols on Recovery in End-Stage Hepatic Alveolar Echinococcosis Patients Undergoing ex vivo Liver Resection and Autotransplantation: a Preliminary Study.

Progress on the HIF-1α/VEGF/VEGFR2 signal pathway in hepatic alveolar echinococcosis.

Frontiers in oncology

International journal for parasitology

Zoonotic Echinococcus granulosus sensu lato genotypes G6 and G7: new insights from the global mitogenome analysis.

International journal of molecular sciences

Host Proteins in Echinococcus multilocularis Metacestodes.

International medical case reports journal

Ex vivo Liver Autotransplantation for Alveolar Echinococcosis with Brain and Lung Metastases: A Case Report.

Serum IgG galactosylation as a potential biomarker for the diagnosis of echinococcosis.

The Analyst

International journal of molecular sciences

Human Alveolar Echinococcosis-A Neglected Zoonotic Disease Requiring Urgent Attention.

Frontiers in parasitology

Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Inhibition of the MyD88/NF-κB pathway alters the Th1/Th2 balance to exacerbate liver injury and hepatic fibrosis in alveolar echinococcosis.

World journal of gastroenterology

Current considerations for the management of liver echinococcosis.

Frontiers in microbiology

Typing of Echinococcus multilocularis by Region-Specific Extraction and Next-Generation Sequencing of the mitogenome.

Diagnostics (Basel, Switzerland)

Advances in Novel Diagnostic Techniques for Alveolar Echinococcosis.

Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the treatment and control of Echinococcus multilocularis and E. granulosus infections in dogs.

CT-based radiomics models using intralesional and different perilesional signatures in predicting the microvascular density of hepatic alveolar echinococcosis.

BMC medical imaging

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Human alveolar echinococcosis-global, regional, and national annual incidence and prevalence rates.

Identifying KLF14 as a potential regulatory factor in liver regeneration trough transcriptomic and metabolomic.

World journal of hepatology

Immunological landscape of hepatic alveolar echinococcosis: A bibliometric analysis.

New evidence from the northern Apennines, Italy, suggests a southward expansion of Echinococcus multilocularis range in Europe.

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis.

mBio

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis.

Alveolar echinococcosis in the canton of Geneva between 2010 and 2021: a descriptive analysis.

Swiss medical weekly

Evaluation of the prevalence of Echinococcus multilocularis in free-roaming dogs in the human alveolar echinococcosis endemic region of Turkey.

Acta tropica

BMC cardiovascular disorders

Multimodal imaging for the diagnosis of cardiac alveolar echinococcosis: a case report.

Past, present and future epidemiology of echinococcosis in China based on nationwide surveillance data 2004-2022.

The Journal of infection

The genetic variation of mitochondrial sequences and pathological differences of Echinococcus multilocularis strains from different continents.

Microbiology spectrum

Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.

Frontiers in medicine

Comparison of ultrasonographic features between two types of hepatic echinococcosis and hepatoblastoma in children.

Frontiers in pediatrics

Journal of orthopaedic surgery (Hong Kong)

Dynamic evaluation of vertebral alveolar echinococcosis using MR T2 mapping.

Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France.

Parasite (Paris, France)

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Risk factor analysis and prediction of multi-organ metastasis in hepatic alveolar echinococcosis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

A ticking time bomb? A position paper on the rising and neglected threat of alveolar echinococcosis in the Republic of Croatia.

Exploring the mechanism and drug candidates of alveolar echinococcosis affecting liver fibrosis through analysis of existing microarray data.

Acta tropica

Expression of TNF-α, VEGF-A and Microvessel Density in Cerebral Alveolar Echinococcosis and Their Correlation with Perilesional Brain Edema.

Acta parasitologica

International journal for parasitology. Drugs and drug resistance

Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis.

ACS applied materials & interfaces

Targeted Theranostic Nanoprobes Assisted In Vivo NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis.

International journal of food microbiology

Detection of Echinococcus spp. and other taeniid species in lettuces and berries: Two international multicenter studies from the MEmE project.

The first case of alveolar echinococcosis from southern Croatia: progressive course of the disease in an immunocompromised patient.

Germs

Hepatobiliary & pancreatic diseases international : HBPD INT

Combined two-step vascular exclusion and modified in situ hypothermic perfusion for advanced hepatic alveolar echinococcosis with cavernous transformation of portal vein (with video).

Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.

World journal of hepatology

Insight into the history and trends of liver transplantation for echinococcosis: A bibliometric analysis.

Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches.

Synergistic Effects of Anti-echinococcosis Drug Candidates Combined With Atovaquone in Culture Assays and Mice With Primary Infections of Echinococcus multilocularis.

Cureus

Echinococcus granulosus sensu lato control measures: a specific focus on vaccines for both definitive and intermediate hosts.

The Journal of parasitology

ECHINOCOCCUS MULTILOCULARIS IN NEW YORK WILDLIFE: DISTRIBUTION AND GENETIC DIVERSITY OF AN EMERGING PATHOGEN.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Narrowing the region of candidate genes that control the development of protoscoleces of Echinococcus multilocularis in the mouse liver.

Frontiers in veterinary science

Risk factors associated with human echinococcosis: a systematic review and meta-analysis.

European journal of radiology

A liver CT based nomogram to preoperatively predict lung metastasis secondary to hepatic alveolar echinococcosis.

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

[Hepatic T cell subtypes and functional analysis among alveolar echinococcosis patients using single-cell RNA sequencing].

Expression and serodiagnostic efficacy of a novel echinococcosis-specific recombinant fusion antigen rAgB8/1-Em18-Eg95.

Parasitology

Progress and perspectives on BMP9-ID1 activation of HIF-1α and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis.

Frontiers in oncology

Travel medicine and infectious disease

Icterus provoked by Echinococcus mimicking a tumor: A diagnostic challenge.

World journal of hepatology

Current status of drug therapy for alveolar echinococcosis.

Zeitschrift fur Gastroenterologie

Alveolar Echinococcosis - Diagnostic challenges of a parasitic disease on the rise in Europe - a case report.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

EchiNam: multicenter retrospective study on the experience, challenges, and pitfalls in the diagnosis and treatment of alveolar echinococcosis in Belgium.

Upregulation of CD244 promotes CD8+ T cell exhaustion in patients with alveolar echinococcosis and a murine model.

Frontiers in veterinary science

Ecological factors associated with fox feces density in an Echinococcus multilocularis endemic zone in Japan.

Supersaturated drug delivery system of albendazole salt-polymer complex for improving oral bioavailability and efficacy anti-secondary E. multilocularis.

Acta tropica

International journal of surgery case reports

EX vivo liver resection and auto transplantation for a giant hepatocellular carcinoma: A case report.

Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond.

Parasitology

Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis.

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