Meningite pneumocócica

Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis

NCT03480191

CONCLUÍDO

Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old.

NCT01478035

DESCONHECIDO

Study Evaluating Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar.

NCT00227214

CONCLUÍDO

Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis

NCT00162578

CONCLUÍDO

Pesquisa e ensaios clínicos

5 ensaios clínicos encontrados.

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NCT03480191 · Adjunction of Daptomycin for the Treatment of Pneumococcal M…Concluído

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NCT01478035 · Study on the Efficacy of Phenytoin in the Prophylaxis of Sei…Encerrado

PHASE4

NCT00227214 · Study Evaluating Pneumococcal Meningitis in the Paediatric P…Concluído

NCT00162578 · Vancomycin Concentration in Cerebrospinal Fluid During Pneum…Concluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

612 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 612

#1

mTORC1 inhibition by sirolimus as adjunctive treatment in experimental pneumococcal meningitis.

Brain communications2026

Sirolimus, an inhibitor of mammalian target of rapamycin complex (mTORC) 1, a regulatory protein involved in seizures and a modulator of inflammation, represents a potential new treatment strategy for pneumococcal meningitis. This study investigates the effects of mTORC1 inhibition using sirolimus in a mouse model of experimental pneumococcal meningitis. In a prospective, investigator-blinded and randomized trial, 96 mice were infected intracisternally with Streptococcus pneumoniae serotype 2. Mice were randomized for treatment with sirolimus and all mice received antibiotic treatment. In a clinical severity experiment, 48 mice were infected and scored every 4 h for disease severity until 72 h. In a time-point experiment, 48 mice were infected and terminated at 6 or 24 h after infection for evaluation. In the clinical severity experiment, sirolimus treatment did not improve survival, although seizures tended to occur less in treated mice [3 of 24 (13%) versus 5 of 24 (21%), P = 0.7]. In the time point experiment, clinical severity scores were increased in sirolimus-treated mice [maximum difference at 24 h after infection with a median of 10 (interquartile range 10-13) versus 7.5 (interquartile range 5-9) at 24 h after infection, P < 0.01]. While bacterial loads were similar across groups, sirolimus treatment increased inflammation. In the brain of treated mice, interleukin 6 was increased (median 8900 pg/ml versus 4804 pg/ml, P = 0.04), while interleukin 12 was elevated in both the brain (median 591 pg/ml versus 405 pg/ml, P = 0.03) and plasma (median 216 pg/ml versus 7 pg/ml, P < 0.01). Our findings illustrate the importance of mTORC1 signalling during pneumococcal meningitis in regulating inflammation. However, our results indicate that sirolimus is unlikely to be an effective treatment for this condition.

#2

Thoughts on Fluoroquinolones in Resistant Pneumococcal Meningitis.

Clinical pediatrics2026 Mar

Asplenia refers to the absence of normal splenic function and may be anatomic or functional secondary to various disease states. The spleen, a major extramedullary lymphoid organ in the left upper quadrant, is typically nonpalpable and averages 10.6 by 5.2 cm, with size varying by sex and race (eg, larger in men and in White individuals than in women or Black individuals). Palpability or radiographic enlargement should prompt evaluation for inherited or acquired causes of splenomegaly. Patients receiving splenic irradiation, particularly 40 Gy or greater, are also at increased risk for developing hypo or asplenia. Functionally, the spleen filters senescent red blood cells, mounts immune responses to infectious pathogens (particularly encapsulated organisms), and supports extramedullary hematopoiesis. The spleen's 2 distinct regions, white pulp and red pulp, mediate these roles: the white pulp generates antigen-specific antibodies, while the red pulp, composed of sinusoids and the cords of Bilroth, filters blood and removes aged cells and circulating microorganisms. As the body's largest blood-filtering organ, the spleen plays a central role in the broader lymphatic system, which includes the lymph nodes, thymus, tonsils, and appendix. Asplenia may result from damage to the white pulp, red pulp, or both, and can arise from disease-related injury, infection, or direct toxic insults. Understanding its etiologies and complications is essential as asplenia significantly increases susceptibility to encapsulated bacteria. Infections with Neisseria meningitides or Streptococcal pneumoniae, and other pathogens can rapidly become life-threatening, and asplenic patients have a reported 200-fold higher risk of death from septicemia than individuals with normal splenic function. Numerous case reports describe fatal outcomes, including pneumococcal meningitis, following splenectomy for refractory immune thrombocytopenia. Mortality in invasive infections remains high at approximately 69% in meningitis, 64% in septicemia, and 7% in purpura fulminans. Invasive group A streptococcal infections, including endocarditis with cardiac rupture, have also been reported. Emerging data from the COVID-19 pandemic indicate that aspenic patients experience higher rates of hospitalization, though not necessarily increased mortality. These findings highlight the importance of vigilant monitoring and timely vaccination in this high-risk population.

#3

A cautionary tale: rapidly progressive moyamoya syndrome following pneumococcal meningitis in an adult with congenital ear malformation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026 Jan 03

#4

Concurrent Detection of Streptococcus pneumoniae and Herpes Simplex Virus Type 1 (HSV-1) in Cerebrospinal Fluid: Clinical Interpretation Beyond Molecular Positivity.

Cureus2026 Feb

Herpes simplex virus type 1 (HSV-1) encephalitis and acute bacterial meningitis are severe central nervous system infections associated with significant morbidity. While typically distinct, the increasing use of multiplex polymerase chain reaction (PCR) panels has led to occasional co-detection, creating diagnostic uncertainty. We describe a 44-year-old previously healthy male diagnosed with culture-confirmed pneumococcal meningitis in whom multiplex cerebrospinal fluid PCR also detected HSV-1. The clinical course was complicated by a generalized seizure on hospital day 3 and the development of ventriculitis on day 14, despite negative repeat microbiological assays. Following targeted antibacterial and antiviral therapy, the patient achieved complete neurological recovery. This case highlights the complexity of interpreting molecular results in the setting of severe blood-brain barrier disruption and emphasizes a cautious, chronologically driven approach to management.

#5

Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance.

Immunotherapy advances2026

Streptococcus pneumoniae (pneumococcus) is a leading cause of bacterial meningitis worldwide and is associated with cerebrovascular complications and long-term neurological sequelae. These outcomes are largely driven by an excessive yet ineffective neuroinflammatory response. Although pneumococci express multiple virulence factors that enable immune evasion, how these factors modulate phagocytic responses in the central nervous system remains unclear. Here, we identify neuraminidase A (NanA) as a critical regulator of phagocytic activation in microglia and macrophages. Using murine and human microglia and RAW 264.7 macrophages, we show that NanA deficiency increases bacterial adhesion, indicating enhanced immune recognition, but paradoxically promotes intracellular bacterial survival. Despite elevated expression of the phagocytic marker CD68, microglia infected with NanA-deficient pneumococci fail to efficiently eliminate intracellular bacteria, as evidenced by unchanged levels of the lysosomal enzyme cathepsin 3 compared with NanA-expressing strains. Treatment with recombinant NanA restored phagocytic activation and significantly enhanced clearance of NanA-deficient bacteria. This effect was dependent on NanA sialidase activity, as enzymatically inactive NanA failed to restore immune sensing. Notably, this immunomodulatory function was specific to the secreted form of NanA produced by the invasive TIGR4 strain and was not observed with membrane-anchored NanA from D39-derived mutants. Together, these findings reveal an unexpected role for NanA in promoting effective innate immune activation and bacterial clearance, highlighting its potential as a therapeutic target for pneumococcal meningitis and invasive pneumococcal disease.

Publicações recentes

High frequency of Streptococcus pneumoniae serotype 10A identified by PCR in cerebrospinal fluid culture-negative paediatric clinical samples.

Enferm Infecc Microbiol Clin (Engl Ed)2026 Apr

Giant Subdural Abscess After Head Trauma.

Clin Case Rep2026 Apr

Gene Polymorphisms of TLR2 Subfamily and Bacterial Meningitis in Angolan Children.

Genes (Basel)2026 Feb 25

Concurrent Detection of Streptococcus pneumoniae and Herpes Simplex Virus Type 1 (HSV-1) in Cerebrospinal Fluid: Clinical Interpretation Beyond Molecular Positivity.

Cureus2026 Feb

Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance.

Immunother Adv2026

Ver todas no PubMed

📚 EuropePMC1.294 artigos no totalmostrando 197

Concurrent Detection of Streptococcus pneumoniae and Herpes Simplex Virus Type 1 (HSV-1) in Cerebrospinal Fluid: Clinical Interpretation Beyond Molecular Positivity.

Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance.

Immunotherapy advances

Mastoiditis With Pneumocephalus on CT: An Uncommon Clue to Underlying Bacterial Meningitis.

Emergence of pneumococcal meningitis outbreak in Northern Togo in 2023, lessons learned and challenges.

BMC public health

Frontiers in public health

Implementation of India's largest sentinel surveillance for meningitis: an exploratory qualitative analysis of the facilitators and challenges in this sentinel site network.

Pneumococcal Meningitis in a Region of Northern Spain, 1993-2023: Incidence Trends, Clinical Features, Recurrences, and Antibiotic Resistance.

Synthetic peptide V11A reduces bacterial load and inflammation in pneumococcal meningitis.

Purulent Streptococcus Pneumoniae meningitis with suppurative focus and infectious vasculitis leading to ischemic and hemorrhagic strokes: A rare case report.

Radiology case reports

The Journal of antimicrobial chemotherapy

Penetration of daptomycin in cerebrospinal fluid during pneumococcal meningitis.

Recurrent Pneumococcal Meningitis From Post-traumatic Frontoethmoidal Encephalocele: A Case Report.

mTORC1 inhibition by sirolimus as adjunctive treatment in experimental pneumococcal meningitis.

Brain communications

International immunopharmacology

PGK1 contributes to blood-brain barrier integrity via PI3K-AKT-mTOR pathway in early pneumococcal meningitis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

A cautionary tale: rapidly progressive moyamoya syndrome following pneumococcal meningitis in an adult with congenital ear malformation.

Invasive Pneumococcal Disease Presenting as Austrian Syndrome in a Patient With HIV Infection: A Case Report.

Fulminant Pneumococcal Meningitis With Neurovascular Complications in an Adult With Sickle Cell Anemia: A Case Report.

The Pediatric infectious disease journal

Recurrent Nontypeable Pneumococcal Meningitis in a Child With Bilateral Cochlear Implants.

Clinical features, epidemiology, treatment, and prognosis of multicentre pediatric pneumococcal meningitis in China from 2019 to 2021.

Long-Term Impact of Pneumococcal Conjugate Vaccines on the Burden of Pneumococcal Meningitis in Mozambique, 2013-2023.

Thoughts on Fluoroquinolones in Resistant Pneumococcal Meningitis.

Clinical pediatrics

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

[Pneumococcal meningitis in a tertiary care hospital: clinical characteristics, serotype distribution, and vaccination status].

Journal of infection and public health

Pneumococcal meningitis in Mexico. Serotype distribution and antimicrobial resistance before and after the introduction of pneumococcal conjugate vaccines in pediatric patients. Results from the GIVEBPVac group.

Anti-cytokine autoantibodies linked to susceptibility, bacterial load, and outcome in pneumococcal meningitis: prospective cohort studies in CNS infections, Alzheimer's disease, and Parkinson's disease.

EBioMedicine

Fulminant Multidrug-Resistant Streptococcus pneumoniae Meningoencephalitis After Elective ENT Surgery: A Case Report.

Microorganisms

Nasopharyngeal swab for the diagnosis of SARS-CoV-2 (COVID-19) infection complicated by severe pneumococcal meningitis.

IDCases

Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium.

Virulence

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Community-acquired bacterial meningitis in Southern Sweden 2013-2023: a population-based study of incidence, aetiology and diagnostic yield.

Human vaccines & immunotherapeutics

Multidimensional analysis of costs and outcomes in a Colombian cohort of pediatric Streptococcus pneumoniae meningitis cases (2017-2022).

Journal of the Belgian Society of Radiology

MRI Findings of Endogenous Endophthalmitis as a Complication of Pneumococcal Meningitis.

Acta neuropathologica communications

Pharmacologic depletion of border-associated macrophages worsens disease in a mouse model of meningitis.

Vaccinated Toddler With 15B/15C Serotype Switch Pneumococcal Meningitis.

Presumed Cerebral Vasculitis Following Pneumococcal Meningitis: A Rare but Life-Threatening Complication.

Case reports in medicine

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Managing penicillin resistant pneumococcal meningitis: an international id-iri study.

Pneumocephalus in pneumococcal meningitis.

Acta neurologica Belgica

Open forum infectious diseases

Dexamethasone as Adjuvant Therapy for Bacterial Meningitis in Children: What About Streptococcus pneumoniae?

Trigeminal TRPV1 regulates pneumococcal nose-to-brain invasion via IL-6/TNF-α signals.

mBio

Seminars in arthritis and rheumatism

CAR T-cell therapy in SLE: A systematic review.

The CSF transcriptome in adults with pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

Immunology letters

Influenza-Associated Streptococcus pneumoniae Meningitis: A Complex Clinical Presentation.

Effects of Pneumococcal Vaccination in Children Under Five Years of Age in the Democratic Republic of Congo: A Systematic Review.

Evolving Landscape of Paediatric Pneumococcal Meningitis in Argentina (2013-2023).

Microorganisms

Oxford medical case reports

Delayed cerebral vasculopathy following pneumococcal meningitis: a case report.

Delayed cerebral infarction in pneumococcal meningitis due to postinfectious vasculitis: A case report.

Medicine

Single cell analysis of diverse immune cell in pneumococcal meningitis.

Pneumococcal meningitis and endotoxemia: A cross-sectional clinical study.

Cohort study exploring the association of cerebrospinal fluid metalloprotease levels and Microbiological characteristics to cerebral vasculitis complication in Pneumococcal meningitis.

Journal of infection and public health

Clinical features and antibiotic resistance in pediatric pneumococcal meningitis in Southern Vietnam, 2012-2023: A multicenter retrospective study.

The Journal of international medical research

Impact of the 13-valent pneumococcal vaccine on Streptococcus pneumoniae serotypes and antibiotic susceptibility in children.

Pneumococcal Meningovasculitis: A Deadly Foe.

Protocol for pneumococcal meningitis induction in mice via non-surgical intracisternal injection.

STAR protocols

Streptococcus p neumoniae Meningitis with Diffuse Cerebral Microhemorrhages.

The Neurohospitalist

Anaesthesiology intensive therapy

Cerebral vasculitis secondary to pneumococcal meningitis. Plasmapheresis as adjuvant therapy. Case report.

Pneumococcal meningitis presenting as stroke: a diagnostic challenge.

BMJ case reports

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Intracranial pressure management in pneumococcal meningitis: first, do no harm.

The Lancet. Child & adolescent health

Adjunctive dexamethasone and 30-day all-cause death after hospital admission in paediatric pneumococcal meningitis: a propensity score analysis.

The Lancet. Child & adolescent health

Dexamethasone for paediatric pneumococcal meningitis.

Clinical features and long-term outcomes of children with pneumococcal meningitis in China: a 10-year single-centre retrospective analysis.

BMC pediatrics

The Pediatric infectious disease journal

High Mortality Due to Pneumococcal Meningitis in Children With Sickle Cell Disease: A French Multicenter Observational Study From 2001 to 2021.

The Annals of otology, rhinology, and laryngology

Preventive Effect of Controlled-Release Dexamethasone on Cochlear Ossification in Meningitis Model.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Mortality and sequelae associated with regional use of intracranial devices among patients with pneumococcal meningitis: a nationwide, population-based cohort study.

Immunity, inflammation and disease

Progranulin Plays a Protective Role in Pneumococcal Meningitis by Inhibiting Pyroptosis.

Global impact of 10- and 13-valent pneumococcal conjugate vaccines on pneumococcal meningitis in all ages: The PSERENADE project.

The Journal of infection

Positive real-time PCR in pneumococcal meningitis 12 hours after initiation of antibiotic therapy - case report.

BMC neurology

Journal of the Pediatric Infectious Diseases Society

Interactions of the Pneumococcus with the Central Nervous System: Postnatal Meningitis Versus Fetal Neurodevelopment.

The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood-Brain Barrier in the Course of Pneumococcal Meningitis.

Cells

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Assessing the Impact of Vaccination Status on Meningitis Risk Post Cochlear Implantation.

The Pan African medical journal

Longitudinally transverse myelitis as a rare complication of pneumococcal meningitis: case report.

Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study.

Annals of intensive care

Understanding the mechanisms of Streptococcus pneumoniae in penetrating the blood-brain barrier: insights into bacterial binding with central nervous system host receptors.

Tissue barriers

Adult Work Ability Following Diagnosis of Bacterial Meningitis in Childhood.

JAMA network open

Annals of Indian Academy of Neurology

Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis.

Internal medicine (Tokyo, Japan)

Bacteremia and Meningitis Caused by Penicillin-resistant Streptococcus pneumoniae Serotype 35B Successfully Treated with Ceftriaxone Combined with Vancomycin Followed by Linezolid.

Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis.

Frontiers in immunology

Effect of 10-valent pneumococcal conjugate vaccine on trends of pneumococcal meningitis in children under five years, Uganda, 2003-2022.

Epidemiology of pneumococcal meningitis in sentinel hospital surveillance of Viet Nam, 2015-2018.

Seizure prophylaxis in pneumococcal meningitis, cohort study.

Epilepsia open

Cost-Effectiveness Analysis of Routine Childhood Immunization with 20-Valent versus 15-Valent Pneumococcal Conjugate Vaccines in Germany.

The Lancet. Child & adolescent health

Characteristics of children with invasive pneumococcal disease eligible for the 1+1 compared with the 2+1 PCV13 infant immunisation schedule in England: a prospective national observational surveillance study.

Advances in the pathogenesis and treatment of pneumococcal meningitis.

Virulence

Deutsche medizinische Wochenschrift (1946)

[Community-Acquired Bacterial Meningoencephalitis: The New Guideline].

Cochlear hemorrhage in a patient with pneumococcal meningitis.

Acta neurologica Belgica

Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis.

JMIR research protocols

Recurrent pneumococcal meningitis in children: Diagnostic dilemma.

La Tunisie medicale

Infectious diseases (London, England)

A 30-year perspective of low-dose dexamethasone, a single dose of mannitol and antiseizures prophylaxis on the prognosis of pneumococcal meningitis.

Community-Acquired Meningitis Complicated With Pyogenic Ventriculitis and Hydrocephalus in a Patient With Haematological Malignancy: A Case Report and Literature Review.

Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients - a Dutch prospective nationwide cohort study.

Infection

A Misdiagnosis of MIS-C: Acute Pneumococcal Meningitis Due to Serotype 19F in A Child with Acute SARS-CoV-2 Infection with a Severe Disease Course.

Klinische Padiatrie

Rapidly Progressive Fatal Pneumococcal Meningitis in a Fully Immunized Child With a History of Facial Bone Fractures.

IL-10-Mediated Regulation of Microglial Inflammation in Brain Meningitis: Novel Insights and Therapeutic Potential.

Discovery medicine

Modelling control strategies for pneumococcal meningitis outbreaks in the African meningitis belt.

Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models.

Brain communications

The single D380 amino acid substitution increases pneumolysin cytotoxicity toward neuronal cells.

iScience

Biphasic Clinical Trajectory in Pneumococcal Meningitis from Cerebral Infarcts.

Neurocritical care

Successful treatment of penicillin-resistant pneumococcal meningitis following ventriculo-peritoneal shunt for congenital hydrocephalus: A case report on the efficacy of linezolid.

Asian journal of surgery

Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes in the cellular environment in bacteremia-derived meningitis.

Neurobiology of disease

A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019-2020.

Cribriform plate dehiscence with encephalomeningocele revealed by recurrent meningitis: A case report.

La Tunisie medicale

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Bacterial load in cerebrospinal fluid predicts unfavourable outcome in pneumococcal meningitis: a prospective nationwide cohort study.

Journal of the Association for Research in Otolaryngology : JARO

Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2.

European heart journal. Case reports

Stress cardiomyopathy in the paediatric population: a case series.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Recurrent community-acquired pneumococcal meningitis in adults with and without identified predisposing factors.

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[A multi-center epidemiological study on pneumococcal meningitis in children from 2019 to 2020].

How common is otogenic meningitis? A retrospective study in southern Sweden over 18 years.

Infection

Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis.

JCI insight

Impact of direct ICU admission of pneumococcal meningitis in France: a retrospective analysis of a French medico-administrative (PMSI) database.

Annals of intensive care

Increased Risk of Long-Term Disabilities Following Childhood Bacterial Meningitis in Sweden.

JAMA network open

International immunopharmacology

Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway.

Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013-2015).

Characteristics and prognostic factors of bacterial meningitis in the intensive care unit: a prospective nationwide cohort study.

Annals of intensive care

Journal of neuroinflammation

Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood-brain barrier function.

Impact of the COVID-19 pandemic on incidence and serotype distribution of pneumococcal meningitis - A prospective, nationwide cohort study from the Netherlands.

The Journal of infection

Corrigendum to "Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana" [Vaccine 37(37) (2019) 5657-5663].

[Pneumococcal meningitis in children in Iceland - case report and summary].

Laeknabladid

Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level.

Frontiers in immunology

Infectious diseases and therapy

Disease Burden of Meningitis Caused by Streptococcus pneumoniae Among Under-Fives in China: A Systematic Review and Meta-analysis.

Journal of global infectious diseases

Pneumococcal Meningitis and Myocarditis in a Splenectomized Patient.

Antibiotic treatment of neuro-meningeal infections.

Infectious diseases now

Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019.

World journal of clinical cases

Persistent dysexecutive syndrome after pneumococcal meningitis complicated by recurrent ischemic strokes: A case report.

Cerebral vasculitis as a complication of pneumococcal meningitis: A cohort study.

Infectious diseases now

The Journal of infectious diseases

Neuropeptide Calcitonin Gene-Related Peptide Promotes Immune Homeostasis of Bacterial Meningitis by Inducing Major Histocompatibility Complex Class II Ubiquitination.

NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis.

Molecular neurobiology

Streptococcus pneumoniae Serotype 23B Causing Asymptomatic Sinusitis Complicated by Endocarditis and Meningitis: Sequela of a Non-vaccine Serotype.

The Lancet regional health. Europe

Trends in laboratory-confirmed bacterial meningitis (2012-2019): national observational study, England.

Systematic Literature Review of the Epidemiological Characteristics of Pneumococcal Disease Caused by the Additional Serotypes Covered by the 20-Valent Pneumococcal Conjugate Vaccine.

Microorganisms

Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study.

BMJ open

Open forum infectious diseases

Childhood Bacterial Meningitis Surveillance in Southern Vietnam: Trends and Vaccination Implications From 2012 to 2021.

Cellular and molecular biology (Noisy-le-Grand, France)

Programmed Cell Death Protein 1/Programmed Cell Death Ligand 1 Signaling Pathway Mediated Interleukin-10 and Bacterial Biofilm Formation to Drug Resistance Mechanism of Pneumoniae Meningitis.

Cerebrovascular complications in patients with community-acquired bacterial meningitis: occurrence and associated factors in the COMBAT multicenter prospective cohort.

The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis.

Cytokine

Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates.

American journal of otolaryngology

Hearing outcomes in children with pneumococcal meningitis in the PCV13 era.

Complicated Invasive Pneumococcal Meningitis: Highlighting the Value of Implementing New Pneumococcal Vaccines.

Takotsubo cardiomyopathy in a 4-year-old female with pneumococcal meningitis.

Cardiology in the young

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Risk factors and pathogen characteristics associated with unfavorable outcomes among adults with pneumococcal meningitis in Japan, 2006 to 2016.

Pneumococcal meningitis in a patient with severe COVID-19 on dexamethasone and tocilizumab: A case report.

IDCases

Labyrinthitis Ossificans in a Post-Splenectomy Patient With Meningitis: A Case Report and Review of Literature.

Critical care (London, England)

Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit.

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection.

Current biology : CB

Frontiers in neuroscience

Dendritic spine loss deep in the neocortex and dendrite distortion with diffusion disturbances occur early in experimental pneumococcal meningitis.

Streptococcus pneumoniae meningitis and the CNS barriers.

Antibiotics (Basel, Switzerland)

Burden of Hospitalizations Related to Pneumococcal Infection in Spain (2016-2020).

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Multiplex PCR to Streptococcus pneumoniae serotype identification directly in cerebrospinal fluid samples.

Steroid Rebound Phenomenon as a Cause of Delayed Cerebral Vasospasm in Post-Splenectomy Pneumococcal Meningitis: A Case Report.

Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq.

Cell reports

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Diagnostic accuracy of rapid antigen tests in cerebrospinal fluid for pneumococcal meningitis: a systematic review and meta-analysis.

Impact of PCV10 on pediatric pneumococcal disease burden in Brazil: time for new recommendations?

Jornal de pediatria

Computational and mathematical methods in medicine

Appraisal and Simulation on Codynamics of Pneumonia and Meningitis with Vaccination Intervention: From a Mathematical Model Perspective.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

Approach to Management of Cerebrospinal Fluid Rhinorrhea: Institutional Based Protocol.

Clinical Vignette of Bacterial Meningitis Complicated by a Cerebrovascular Event.

Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model.

Immunology letters

Chronic recurrent delayed cerebral vasculopathy after pneumococcal meningitis.

Acta neurologica Belgica

Antimicrobial agents and chemotherapy

Penicillin- and Cephalosporin-Resistant Pneumococcal Meningitis: Treatment in the Real World and in Guidelines.

Acta neuropathologica communications

The role of plasminogen activator inhibitor-2 in pneumococcal meningitis.

Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10.

Frontiers in pediatrics

Annals of clinical and laboratory science

Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.

International journal of emergency medicine

Pneumococcal meningitis secondary to otitis media in two patients with COVID-19 omicron variant.

Cerebrospinal fluid sex steroid hormones in bacterial meningitis.

Medicine

Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis.

mBio

Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis.

Nature communications

A Common Neurological Presentation With an Unusual Etiology: Dense Hemiplegia Due to Pneumococcal Meningitis.

Internal medicine (Tokyo, Japan)

Reversible Centripetal Cerebral Vasculitis in Pneumococcal Meningitis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020.

Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center.

Frontiers in pediatrics

Comparative effectiveness of individual pneumococcal vaccines with dual pneumococcal vaccination in older United States Veterans.

Non-steroidal anti-inflammatory drugs ketorolac and etodolac can augment the treatment against pneumococcal meningitis by targeting penicillin-binding proteins.

Microbial pathogenesis

The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis.

Pneumococcal meningitis in Greece: A retrospective serotype surveillance study in the post-PCV13 era (2010-2020).

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Improving Pneumococcal Vaccination Rates in Cochlear Implant Programs: A Systematic Review and Meta-analysis.

Arnold Netter Netter (1855-1936) and infectious pathology of the nervous system.

Revue neurologique

Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborative for Audit and Research (NITCAR).

BMJ open

2021

Diminished Pneumococcal-Specific CD4+ T-Cell Response is Associated With Increased Regulatory T Cells at Older Age.

Frontiers in aging

[Cranial multineuritis and transverse myelitis as complications of pneumococcal meningitis].

Revista de neurologia

Public Health Value of a Hypothetical Pneumococcal Conjugate Vaccine (PCV) Introduction: A Case Study.

NOD2-RIP2 signaling alleviates microglial ROS damage and pyroptosis via ULK1-mediated autophagy during Streptococcus pneumonia infection.

Neuroscience letters

Ceftaroline versus standard therapy for pneumococcal meningitis in critically ill patients.

Medicina intensiva

Immune gains through brain drains.

Science immunology

Long-term neuro-functional disability in adult patients with community-acquired bacterial meningitis.

Infection

Spontaneous Cerebro-Spinal Fluid Rhinorrhoea Caused by Sustained Intracranial Hypertension.

Infectious diseases and therapy

Combined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?

British journal of neurosurgery

First reported case of hydrocephalus in jointly diagnosed bacterial meningitis and a colloid cyst: how Ockham's razor became Hickam's dictum.

The Pediatric infectious disease journal

Bacterial Meningitis in Children With Sickle Cell Disease in Angola.

Etiology of meningitis among adults in three quaternary hospitals in Mozambique, 2016-2017: The role of HIV.

Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.

Streptococcus pneumoniae Strains Isolated From a Single Pediatric Patient Display Distinct Phenotypes.

Clinical and Bacteriological Analysis of Pediatric Pneumococcal Meningitis after 13-Valent Pneumococcal Conjugate Vaccine Introduction in Japan.

Microbiology spectrum

Journal of internal medicine

Bacterial meningitis: Aetiology, risk factors, disease trends and severe sequelae during 50 years in Sweden.

Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic.

Journal of neurology

The epidemiology and outcomes of central nervous system infections in Far North Queensland, tropical Australia; 2000-2019.

Prevalence and significance of anaemia in childhood bacterial meningitis: a secondary analysis of prospectively collected data from clinical trials in Finland, Latin America and Angola.

BMJ open

2021

Early neonatal respiratory distress revealing meningitis caused by Streptococcus pneumoniae serotype 17F: a case report.

African health sciences

Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count.

The Journal of infection

Case Report: Persistency Pneumococcal Polysaccharide in Cerebrospinal Fluid During a Post Pneumococcal Chronic Aseptic Meningitis: Coincidental or (Auto-)Inflammatory Embers.

Frontiers in pediatrics

Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan.

Pneumococcal meningitis and COVID-19: dangerous coexistence. A case report.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Penicillin- and third-generation cephalosporin-resistant strains of Streptococcus pneumoniae meningitis: Case report and literature review.

The Journal of infectious diseases

Corrigendum to: Pneumococcal Meningitis Outbreaks in Africa, 2000-2018: Systematic Literature Review and Meningitis Surveillance Database Analyses.