A síndrome da polipose hiperplásica é uma doença intestinal genética rara caracterizada pela presença de múltiplos pólipos colorretais hiperplásicos/serrilhados (geralmente grandes), geralmente com distribuição pancolônica. A histologia revela pólipos hiperplásicos, adenomas serrilhados sésseis (mais comuns), adenomas serrilhados tradicionais ou pólipos mistos. Está associado a um risco pessoal e familiar aumentado (parentes de primeiro grau) de câncer colorretal.
Introdução
O que você precisa saber de cara
A síndrome da polipose hiperplásica é uma doença intestinal genética rara caracterizada pela presença de múltiplos pólipos colorretais hiperplásicos/serrilhados (geralmente grandes), geralmente com distribuição pancolônica. A histologia revela pólipos hiperplásicos, adenomas serrilhados sésseis (mais comuns), adenomas serrilhados tradicionais ou pólipos mistos. Está associado a um risco pessoal e familiar aumentado (parentes de primeiro grau) de câncer colorretal.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 7 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Autosomal dominant, Multigenic/multifactorial, Unknown.
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)
Cell membraneEndoplasmic reticulum membraneNucleus envelope
Sessile serrated polyposis cancer syndrome
A rare disease characterized by multiple and/or large serrated polyps developing in the colon, and an increased personal and familial risk of colorectal cancer. A patient is diagnosed with SSPCS if at least one of the following criteria is met: the presence of at least five sessile serrated polyps proximal to the sigmoid colon, two of which are greater than 10 mm in diameter; the presence of any number of serrated polyps occurring proximal to the sigmoid colon in an individual who has a first-degree relative with serrated polyposis; the presence of more than 20 serrated polyps of any size distributed throughout the colon. Sessile serrated polyps are also known as sessile serrated adenomas (SSA) and are estimated to be responsible for 20 to 35% of all colon cancers. Individuals with SSPCS may have a strong personal or family history of extracolonic cancers.
Variantes genéticas (ClinVar)
210 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
2 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome com polipose hiperplástica
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
5 ensaios clínicos encontrados.
Publicações mais relevantes
Low Yield of Genetic Testing in Serrated Polyposis Syndrome.
Serrated polyposis syndrome (SPS) is clinically defined by the presence of multiple serrated polyps in the colon and rectum, and is associated with increased colorectal cancer risk. SPS is the most prevalent polyposis condition; however, its genetic basis remains poorly characterized. The British Society of Gastroenterology recommends gene panel testing for all patients with SPS to rule out other polyposis conditions. The aim of this study was to evaluate the diagnostic yield of genetic testing in patients with SPS. We conducted a retrospective, cross-sectional analysis using the Polyposis Registry from St. Mark's Hospital, London, a national referral center in the United Kingdom. Patients with SPS who underwent genetic testing between April 4, 2009 and February 9, 2024, and met the SPS WHO criteria were included. Genetic variants were identified from test reports, and clinical data were extracted from medical records. In total, 573 people with SPS were identified in our registry, of whom 258 underwent genetic testing. Of these, 119 underwent target gene testing and 139 underwent multigene panel testing. No pathogenic variants were detected through targeted genetic testing. On multigene panel testing, pathogenic germline variants were found in 4 patients (2.9%), including 3 with Lynch syndrome (2 with PMS2 , one with MSH2 ) and one with an RNF43 variant. Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing seems to have limited utility in patients with SPS and may primarily identify those with an incidental diagnosis of Lynch syndrome.
Two duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.
The serrated neoplastic pathway has been reported to be involved in the development of colorectal cancer, and serrated lesions are recognized to have malignant potential. Recently, serrated lesions of the duodenum have been increasingly reported. Serrated polyposis syndrome (SPS) is characterized by multiple serrated lesions in the colon; however, it is unknown whether serrated lesions in the duodenum occur in patients with SPS. A 58-year-old man with SPS underwent a routine colonoscopy. When he underwent esophagogastroduodenoscopy for screening, two 4-mm white flat-elevated lesions in the second portion of the duodenum were found. The biopsy results were suggestive of sessile serrated lesions (SSLs); therefore, we performed endoscopic mucosal resection with a cap-fitted pan-endoscope for therapeutic purposes. Pathology results showed an SSL in the duodenum. One SSL lesion was positive for the BRAF mutation; multiple duodenal SSLs in patients with SPS are rare, and there are no previous reports of BRAF mutation-positive SSLs. The grade and molecular abnormalities of duodenal SSLs are currently unknown, as is the relationship between SPS and duodenal SSL. Further case accumulation is expected.
Overview of serrated polyposis syndrome from pathophysiology, diagnosis, and management.
This editorial discusses Thompson et al's original article, which is published in the most recent edition of the World Journal of Clinical Oncology and sheds critical light on the intertwined issues of health anxiety and work loss in individuals diagnosed with serrated polyposis syndrome (SPS). SPS is rare, characterized by the development of multiple serrated colorectal polyps. This editorial provides an overview of SPS, including its pathophysiology, clinical presentation, diagnostic criteria, management strategies, and the psychosocial impact. SPS is linked to molecular alterations, which drive carcinogenesis. Colonoscopy and histological analysis are used for diagnosis. Genetic testing is also considered where there is a family history. Quality of life can be greatly impacted by the psychosocial effects of SPS, especially health anxiety. Further understanding of the molecular mechanisms and creating individualized surveillance are required.
Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-pos) and without (Gene-neg) a known genetic driver, remain comparatively unexplored. Using colon biopsies, polyps, and stool from patients with Gene-pos adenomatous polyposis (N = 9), Gene-neg adenomatous polyposis (N = 18), and serrated polyposis syndrome (SPS, N = 11), we demonstrated through 16S rRNA sequencing that the mucosa-associated microbiota in individuals with colonic polyposis is representative of the microbiota associated with small polyps, and that both Gene-pos and SPS cohorts exhibit differential microbiota populations relative to Gene-neg polyposis cohorts. Furthermore, we used these differential microbiota taxa to perform linear discriminant analysis to differentiate Gene-neg subjects from Gene-pos and from SPS subjects with an accuracy of 89% and 93% respectively. Stool metabolites were quantified via 1H NMR, revealing an increase in alanine in SPS subjects relative to non-polyposis subjects, and Partial Least Squares Discriminant Analysis (PLS-DA) analysis indicated that the proportion of leucine to tyrosine in fecal samples may be predictive of SPS. Use of these microbial and metabolomic signatures may allow for better diagnostric and risk-stratification tools for colonic polyposis patients and their families as well as promote development of microbiome-targeted approaches for polyp prevention.
Health anxiety and work loss in patients diagnosed with serrated polyposis syndrome: A cross sectional study.
Serrated polyposis syndrome (SPS) is a polyposis condition with neoplastic potential, but its psychological impact is not well understood. To assess health anxiety prevalence in a regional Australian cohort of SPS patients and explore factors influencing it, including workforce impacts of regular surveillance. This cross-sectional study screened patients aged 18-65 undergoing colonoscopy in a regional gastroenterology practice between January 2015 and June 2022. Eligible SPS patients were invited to participate. Data included the Short Health Anxiety Inventory, employment status, and previous demographic and medical findings. Health anxiety was found in 21.57% of SPS patients, with anxious patients being significantly more concerned about surveillance (OR = 7.70). Patients lost an average of 11.04 work hours per colonoscopy. Health anxiety in SPS patients aligns with rates in other gastroenterology populations. Identifying it may improve management, though further research is needed to better understand prevalence and care improvements.
Publicações recentes
Identifying Serrated Polyposis Syndrome in a Large Health-Care System.
Low Yield of Genetic Testing in Serrated Polyposis Syndrome.
Determinants of high sessile serrated lesion detection: Role of faecal occult blood test and colonoscopy quality indicators.
Two duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.
Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome.
📚 EuropePMC116 artigos no totalmostrando 125
Low Yield of Genetic Testing in Serrated Polyposis Syndrome.
Clinical and translational gastroenterologyDeterminants of high sessile serrated lesion detection: Role of faecal occult blood test and colonoscopy quality indicators.
World journal of gastrointestinal endoscopyTwo duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.
Clinical journal of gastroenterologyGermline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome.
International journal of cancerOverview of serrated polyposis syndrome from pathophysiology, diagnosis, and management.
World journal of clinical oncologyMicrobiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
Gut microbesHealth anxiety and work loss in patients diagnosed with serrated polyposis syndrome: A cross sectional study.
World journal of clinical oncologyCancer pathways in serrated polyposis syndrome: is conventional more crucial than serrated?
Journal of gastroenterologyGermline pathogenic variants in RNF43 in patients with and without serrated polyposis syndrome.
Familial cancer[Familial occurrence of colorectal cancer: prevention, aftercare and genetic counseling].
PraxisGermline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome.
International journal of molecular sciencesGenetic Testing of Japanese Patients with Serrated Polyposis Syndrome: A Multicentric Study.
Journal of the anus, rectum and colonUsing a Population Database to Assess Lifestyle Factors in Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.
Gastro hep advancesSerrated polyposis syndrome: defining the epidemiology and predicting the risk of dysplasia.
BMC gastroenterologyEvaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.
Familial cancerPathology of Gastrointestinal Polyposis Disorders.
Gastroenterology clinics of North AmericaInherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family.
Familial cancerFeasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.
Digestive diseases (Basel, Switzerland)Frequency of serrated polyposis syndrome recognition by community endoscopists.
Endoscopy international openPolyps and Colorectal Cancer in Serrated Polyposis Syndrome: Contribution of the Classical Adenoma-Carcinoma and Serrated Neoplasia Pathways.
Clinical and translational gastroenterologySmall Colon Polyp With Unusual Thickening of the Surrounding Mucosa in a Young Patient.
GastroenterologyAppendiceal lesions in serrated polyposis patients are easily overlooked but only seldomly lead to colorectal cancer.
EndoscopyUnraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome.
Frontiers in molecular biosciencesImpact of changing diagnostic criteria on the diagnosis of serrated polyposis syndrome.
Endoscopy international openBody Mass Index, sex, non-steroidal anti-inflammatory drug medications, smoking and alcohol are differentially associated with World Health Organisation criteria and colorectal cancer risk in people with Serrated Polyposis Syndrome: an Australian case-control study.
BMC gastroenterologyPure somatic pathogenic variation profiles for patients with serrated polyposis syndrome: a case series.
BMC research notesGermline mutations in WNK2 could be associated with serrated polyposis syndrome.
Journal of medical geneticsSerrated polyposis syndrome; epidemiology and management.
Best practice & research. Clinical gastroenterologySerrated Polyposis Syndrome in a Young Adolescent Patient.
Journal of pediatric gastroenterology and nutritionPromotion Effects of Smoking in Polyp Development in Monozygotic Twins with Atypical Colorectal Polyposis.
Case reports in gastroenterologySerrated polyps: innocent or guilty?
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del PeruEpigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome.
The Journal of molecular diagnostics : JMDSynchronized early gastric cancer occurred in a patient with serrated polyposis syndrome: A case report.
World journal of clinical casesClinicopathological Correlates of Dysplastic Sessile Serrated Lesion: A Prospective Cohort Study With a High Detection Rate.
Gastro hep advancesSerrated polyposis syndrome with multiple inverted lesions in the colon: Case report and elucidation of morphogenetic mechanism.
DEN openClinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan.
Journal of gastroenterologyColorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome.
Journal of gastroenterologyGermline variant testing in serrated polyposis syndrome.
Journal of gastroenterology and hepatologyCurrent Approaches in Managing Colonic Serrated Polyps and Serrated Polyposis.
Annual review of medicineGenotypic and Phenotypic Characteristics of Hereditary Colorectal Cancer.
Annals of coloproctologyCancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.
The American journal of gastroenterologySerrated polyps and polyposis of the colon: a brief review for surgeon endoscopists.
Canadian journal of surgery. Journal canadien de chirurgiePrevalence of adenomatous polyposis in a fecal immunochemical test-based colorectal cancer screening program and risk of advanced neoplasia during follow-up.
EndoscopyA Rare Case of Serrated Polyposis Syndrome with the MSH6 and SMARCA4 variants.
European journal of case reports in internal medicineDiagnosis, epidemiology and management of serrated polyposis syndrome: a comprehensive review of the literature.
American journal of translational researchRisk of Colorectal Cancer in Serrated Polyposis Syndrome: A Systematic Review and Meta-analysis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationUlcerative Colitis With Concomitant Serrated Polyposis Syndrome: A Case Report and Literature Review.
CureusSafety and efficacy of band ligation and auto-amputation as adjunct to EMR of colonic large laterally spreading tumors, and polyps not amenable to routine polypectomy.
Therapeutic advances in gastrointestinal endoscopyAppendoscopy in patients with serrated polyposis syndrome.
GutLong-Term Incidence of Advanced Colorectal Neoplasia in Patients with Serrated Polyposis Syndrome: Experience in a Single Academic Centre.
CancersGermline and Somatic Whole-Exome Sequencing Identifies New Candidate Genes Involved in Familial Predisposition to Serrated Polyposis Syndrome.
CancersLong-Term Outcomes of Patients with Serrated Polyposis Syndrome.
Gastroenterology[Gastrointestinal polyposis syndromes].
Der InternistLong-term surveillance in individuals with serrated polyposis syndrome.
Gastrointestinal endoscopyRNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps.
HistopathologySerrated Polyposis Syndrome with a Synchronous Colon Adenocarcinoma Treated by an Endoscopic Mucosal Resection.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiSerrated Polyposis Syndrome: Increasing Awareness and Importance.
CureusIs it time to consider prophylactic appendectomy in patients with serrated polyposis syndrome undergoing surveillance?
GutFirst case of serrated lesion of the duodenal papilla in a patient with serrated colonic polyposis.
Clinics and research in hepatology and gastroenterologyNeoplastic meningitis due to colorectal cancer.
Clinical journal of gastroenterologyA natural language-based tool for diagnosis of serrated polyposis syndrome.
Gastrointestinal endoscopyThe long-term outcomes and natural disease course of serrated polyposis syndrome: over 10 years of prospective follow-up in a specialized center.
Gastrointestinal endoscopyNarrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy.
BMC gastroenterologyColorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility.
Journal of medical geneticsA Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors.
Cancer prevention research (Philadelphia, Pa.)Update on the World Health Organization Criteria for Diagnosis of Serrated Polyposis Syndrome.
GastroenterologyOcular manifestations in celiac disease: an overview.
International ophthalmologyThe (ir)relevance of the abandoned criterion II for the diagnosis of serrated polyposis syndrome: a retrospective cohort study.
Familial cancerHereditary or Not? Understanding Serrated Polyposis Syndrome.
Current treatment options in gastroenterologyIdentification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing.
Clinical and translational gastroenterologyPractical management of polyposis syndromes.
Frontline gastroenterologyOptimal Endoscopic Treatment and Surveillance of Serrated Polyps.
Gut and liverSerrated Polyposis Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationLow Incidence of Advanced Neoplasia in Serrated Polyposis Syndrome After (Sub)total Colectomy: Results of a 5-Year International Prospective Cohort Study.
The American journal of gastroenterologySerrated polyposis syndrome: time to rethink endoscopic treatment and surveillance.
Gastrointestinal endoscopyEndocuff-assisted colonoscopy for surveillance of serrated polyposis syndrome: a multicenter randomized controlled trial.
EndoscopyPersonalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study.
Gut[French comment on article High incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome].
EndoscopyScreening Relevance of Sessile Serrated Polyps.
Clinical endoscopyBRAF mutation: Current and future clinical pathological applications in colorectal carcinoma.
Histology and histopathologyHigh prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors.
CancerReasons why the diagnosis of serrated polyposis syndrome is missed.
European journal of gastroenterology & hepatologyEndoscopic control of polyp burden and expansion of surveillance intervals in serrated polyposis syndrome.
Gastrointestinal endoscopyDiagnosis of Serrated Polyposis Syndrome in an Adolescent Patient.
Clinical pediatrics[French comment on article The clinical significance and synchronous polyp burden of large (≥ 20mm) sessile serrated polyps in patients without serrated polyposis syndrome].
EndoscopyPanchromoendoscopy Increases Detection of Polyps in Patients With Serrated Polyposis Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationAdenocarcinoma of the anal canal with an exceptional immunohistochemistry in a patient with serrated polyposis syndrome: a diagnostic challenge.
Revista espanola de enfermedades digestivasHigh incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome.
EndoscopyAcetic acid spray contribution in the endoscopic diagnosis of serrated polyposis syndrome.
VideoGIE : an official video journal of the American Society for Gastrointestinal EndoscopyThe clinical significance and synchronous polyp burden of large (≥ 20 mm) sessile serrated polyps in patients without serrated polyposis syndrome.
EndoscopySerrated Polyposis Syndrome in a Single-Center 10-Year Experience.
Balkan medical journalHereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Seminars in diagnostic pathologyExome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS).
Hereditary cancer in clinical practicePathology and genetics of hereditary colorectal cancer.
PathologyMultiple Serrated Polyps and Serrated Polyposis Syndrome: Equally Hazardous?
GastroenterologySerrated polyposis syndrome may go undiagnosed even in structured colorectal cancer screening programmes performed by endoscopists with otherwise good quality indices.
GutSerrated polyposis syndrome associated with long-standing inflammatory bowel disease.
Revista espanola de enfermedades digestivasClinical predictors for sessile serrated polyposis syndrome: A case control study.
World journal of gastrointestinal endoscopyClinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients.
Intestinal researchSerrated lesions and serrated polyposis syndrome.
Revista espanola de enfermedades digestivasHereditary Colorectal Cancer Syndromes.
The Surgical clinics of North AmericaGastrointestinal tract cancers: Genetics, heritability and germ line mutations.
Oncology lettersBritish Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
GutIncreased Risk of Colorectal Cancer in Patients With Multiple Serrated Polyps and Their First-Degree Relatives.
GastroenterologyA Case with Serrated Polyposis Syndrome Controlled by Multiple Applications of Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection.
The American journal of case reportsReducing the polyp burden in serrated polyposis by serial colonoscopy: the impact of nationally coordinated community surveillance.
The New Zealand medical journal[French comment on article Reassessment colonoscopy to diagnose serrated polyposis syndrome in a colorectal cancer screening population].
EndoscopySerrated Polyps and Serrated Polyposis Syndrome.
Clinics in colon and rectal surgeryNovel findings in colorectal polyp surveillance.
Gastroenterologia y hepatologiaPrevalence of serrated polyposis syndrome in an FIT-based colorectal cancer screening cohort in Italy.
Gut[Research progress of serrated polyposis syndrome].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgeryReassessment colonoscopy to diagnose serrated polyposis syndrome in a colorectal cancer screening population.
EndoscopyLack of evidence for germline RNF43 mutations in patients with serrated polyposis syndrome from a large multinational study.
GutGene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.
Cancer prevention research (Philadelphia, Pa.)Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview.
GutSerrated polyposis syndrome: risk stratification or reduction?
GutSerrated polyposis syndrome: a silent killer when undetected.
Endoscopy[A Case of Serrated Polyposis Syndrome with Early Colon Cancer].
Gan to kagaku ryoho. Cancer & chemotherapyClinical risk factors of colorectal cancer in patients with serrated polyposis syndrome: a multicentre cohort analysis.
GutEndoscopic and histologic findings in serrated polyposis syndrome.
Gastrointestinal endoscopyColorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study.
GutLow prevalence of serrated polyposis syndrome in screening populations: a systematic review.
EndoscopyClinicopathological Characteristics of Serrated Polyposis Syndrome in Korea: Single Center Experience.
Gastroenterology research and practiceA morphologic reappraisal of endoscopically but not histologically apparent polyps and the emergence of the overlooked goblet cell--rich hyperplastic polyp.
Human pathology[The danger of serrated polyps in the colon: from sporadic polyp to polyposis syndrome].
Nederlands tijdschrift voor geneeskundeAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Comunidades
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Low Yield of Genetic Testing in Serrated Polyposis Syndrome.
- Two duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.
- Overview of serrated polyposis syndrome from pathophysiology, diagnosis, and management.
- Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
- Health anxiety and work loss in patients diagnosed with serrated polyposis syndrome: A cross sectional study.
- Identifying Serrated Polyposis Syndrome in a Large Health-Care System.
- Determinants of high sessile serrated lesion detection: Role of faecal occult blood test and colonoscopy quality indicators.
- Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:157798(Orphanet)
- MONDO:0015524(MONDO)
- GARD:16982(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55781391(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
