São condições que afetam o intestino, onde há perda de proteínas do sangue pelo sistema digestivo — como a albumina e as imunoglobulinas (que são anticorpos) — e, às vezes, de linfócitos (células de defesa). Em casos graves, isso pode levar à falta de gamaglobulinas (um tipo de anticorpo) ou de linfócitos. Essas doenças intestinais que causam perda de proteína estão ligadas a várias outras condições, incluindo a linfangiectasia intestinal, a doença de Whipple e tumores no intestino delgado.
Introdução
O que você precisa saber de cara
São condições que afetam o intestino, onde há perda de proteínas do sangue pelo sistema digestivo — como a albumina e as imunoglobulinas (que são anticorpos) — e, às vezes, de linfócitos (células de defesa). Em casos graves, isso pode levar à falta de gamaglobulinas (um tipo de anticorpo) ou de linfócitos. Essas doenças intestinais que causam perda de proteína estão ligadas a várias outras condições, incluindo a linfangiectasia intestinal, a doença de Whipple e tumores no intestino delgado.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 14 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 31 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Autosomal recessive.
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complem
Cell membraneSecreted
Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy
An autosomal recessive disease characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease. Patients' T lymphocytes show increased complement activation causing surface deposition of complement and the generation of soluble C5a.
Variantes genéticas (ClinVar)
47 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 14 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
4 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome de hiperativação do complemento-trombose angiopática-enteropatia com perda de proteína
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Hepatic vein angioplasty and stenting in a paediatric patient with Budd-Chiari syndrome secondary to CHAPLE syndrome: is endovascular therapy the answer?
CHAPLE syndrome is a recently described genetic disorder characterised by dysregulation of the complement pathway, with the acronym standing for 'CD55 deficiency with complement hyperactivation, angiopathic thrombosis and protein-losing enteropathy'. Some patients develop thrombotic complications such as Budd-Chiari syndrome (BCS). Due to its rarity, management guidelines are lacking. We attempted endovascular angioplasty and stenting of the thrombosed right hepatic vein in a male child with BCS secondary to CHAPLE, diagnosed by symptoms and genetic testing. This case is potentially the first documented instance of CHAPLE syndrome associated with BCS in which endovascular therapy was used. The child was on enoxaparin post procedure, and although ascites and effusions initially improved, the stent occluded, necessitating repeat angioplasty and stenting 5 days later. Re-thrombosis occurred despite good intraoperative flow, leading to supportive care to manage symptoms. Our case shows limited benefits of endovascular therapy in such cases.
Familial colorectal cancer: risk factors, screening strategies and personalized medicine.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with approximately 25-30 % of cases exhibiting a familial component driven by germline mutations in DNA mismatch repair genes (Lynch syndrome) or the APC gene (familial adenomatous polyposis). Despite advances in screening and early detection, significant challenges persist in identifying at-risk individuals, optimizing surveillance strategies and addressing disparities in access to genetic testing and preventive care. This narrative review synthesizes current evidence on the genetic underpinnings, modifiable risk factors and personalized screening approaches for familial CRC. We highlight the critical interplay between hereditary predisposition and environmental exposures including diet, obesity, smoking and gut microbiome alterations, which cumulatively influence disease penetrance and clinical outcomes. Emerging predictive models integrating family history, polygenic risk scores and proteomic biomarkers offer unprecedented opportunities for risk stratification, enabling tailored screening initiation and intervals that balance clinical efficacy with cost-effectiveness. Novel non-invasive biomarkers, such as circulating tumor DNA and stool RNA tests, demonstrate promising sensitivity and specificity, potentially enhancing patient adherence while complementing gold-standard colonoscopy. Furthermore, artificial intelligence-assisted endoscopy and comprehensive genetic panels are reshaping precision oncology by improving adenoma detection rates and guiding targeted therapies. Addressing social determinants of health and implementing structured genetic counseling remain essential to achieving equitable CRC prevention. By transitioning from age-based to individualized, risk-adapted screening paradigms, healthcare systems can significantly reduce CRC incidence and mortality, particularly among genetically predisposed populations.
Reconsidering the LARS score: a cross-sectional descriptive study exploring complementary screening approaches for low anterior resection syndrome.
The LARS score is a practical tool to screen for bowel dysfunction after rectal cancer surgery. However, clinical experience suggests that it may overlook relevant symptoms and/or overestimate impact in some patients. This study aimed to explore whether the International Consensus Definition of LARS complements the LARS score in identifying patients with bowel dysfunction. We conducted a cross-sectional study including patients treated for rectal cancer across two hospitals between January 2021 and December 2024. Demographic and clinical data were collected retrospectively. Functional outcomes were assessed during outpatient follow-up using both the LARS score and the International Consensus Definition criteria. Sixty-two patients were included. According to the LARS score, 39 (62.9%) had "no LARS", 10 (16.1%) "minor LARS" and 13 (21%) "major LARS". Using the International Consensus Definition, 24 (38.7%) met the criteria for LARS. Nine patients (14.5%) were classified differently by the two tools. Five patients classified as "no LARS" by the LARS score met the International Consensus Definition due to unpredictable bowel function and emptying difficulties with a reported impact on daily life. In contrast, four patients with "minor or major LARS" did not meet the International Consensus Definition criteria because no consequences were reported. In this exploratory cross-sectional cohort, the International Consensus Definition did not identify substantially more patients than the LARS score but provided complementary information by linking symptoms to their perceived consequences. Combining both tools may offer a more comprehensive appraisal of LARS until newer multidimensional instruments become available.
Effectiveness comparisons of acupoint stimulation therapies for irritable bowel syndrome: A Bayesian network meta‑analysis.
Irritable bowel syndrome (IBS) is a chronic functional disorder that significantly impacts patient health, causing physical discomfort and diminished quality of life. We aimed to compare various acupoint stimulation modalities for treating IBS using network meta-analysis (NMA). We conducted a systematic search of five electronic databases (PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, and ClinicalTrials.gov) for randomized controlled trials (RCTs) on acupoint stimulation interventions for IBS published from inception to November 8, 2024, without language restrictions. Two authors independently performed data extraction and assessed the risk of bias. Outcomes included symptom severity and quality of life. Bayesian NMA was conducted using STATA 14.0 and Open BUGS 3.2.3. We identified 12 RCTs that included three different acupoint stimulation interventions (1839 participants)-namely, acupuncture, moxibustion, and placebo. Our NMA results showed that the three acupoint stimulation intervention therapies were effective in reducing symptom severity and improving the quality of life for patients with IBS. The most effective acupoint stimulation intervention was moxibustion, which significantly reduced symptom severity (mean difference [MD] = 101.50; 95 % credible interval [CrI]: 80.36, 122.30) and improved quality of life (MD = -19.75; 95 % CrI: -28.86, -10.75) compared to conventional medication in patients with IBS. Moreover, the adverse events of all interventions were acceptable. The NMA suggests that moxibustion was the most effective modality in alleviating symptom severity and improving quality of life in patients with IBS, followed by acupuncture.
Differential and complementary effects of Baizhu and Fuling on spleen deficiency syndrome by regulating microbiota-gut-metabolite axis.
Atractylodes macrocephala Koidz. (commonly known as Baizhu, BZ) and Poria cocos (Schwan.) Wolf. (referred to as Fuling, FL) are frequently employed in the treatment of spleen deficiency syndrome (SDS) owing to their spleen-tonifying and dampness-eliminating properties. The combination of the two herbs, referred to as the BZ-FL herb pair, exhibited complementary and enhancing effects. Nevertheless, the distinct and complementary mechanisms and effects of BZ and FL individually remain inadequately understood. This study aimed to investigate the differential and complementary effects and underlying mechanisms of BZ and FL on SDS. The chemical components in BZ, FL, and the BZ-FL herb pair were qualitatively and quantitatively analyed using UHPLC-Q Exactive HF-X and UPLC-MS technique. SDS model rats were established by a combination of dietary and fatigue-inducing methods and then treated with BZ, FL, and the BZ-FL herb pair. In order to elucidate the effects on gastrointestinal motility, immune function, and water metabolism, the concentrations of gastrointestinal hormones, low-density lipoprotein, high-density lipoprotein, total cholesterol, serum protein levels, and albumin were measured. Additionally, the levels of IL-2, IgA, IL-4, IgG, and IFN-γ in colon tissue were quantified utilizing enzyme-linked immunosorbent assay (ELISA) and biochemical assays. Pathological changes were examined using hematoxylin and eosin staining, while immunofluorescence was used to measure the levels of the intestinal barrier proteins and aquaporins (Aqps) in colonic tissues. The levels of Aqps and cAMP/PKA/CREB signaling pathway were detected in colon and kidney tissues using western blot analysis. Untargeted metabolomics was used to analyze the serum and feces metabolic profile. The 16S rRNA gene high-throughput sequencing was performed to detect the gut microbiota composition in fecal samples. The quantification of chemical components revealed that BZ significantly enhanced the dissolution of triterpene acids from FL. BZ, FL, and the BZ-FL herb pair effectively mitigated SDS by modulating gastrointestinal hormones, kidney and colon Aqps, and protein expression within the cAMP/PKA/CREB signaling pathway, while also enhancing intestinal barrier integrity. Serum metabolomics analysis demonstrated that BZ influenced bile acid biosynthesis, FL affected the citrate cycle and glycerophospholipid metabolism, and the BZ-FL herb pair impacted all these pathways. Gut microbiota analysis indicated that the efficacy of the BZ-FL herb pair in ameliorating SDS was associated with a preserved gut microbiome, characterized by the relative abundance of microbial taxa such as Escherichia-Shigella, Kurthia, and UCG-005. Fecal metabolomics analysis indicated that the BZ-FL herb pair synergistically enhances and complements each other by influencing metabolites in butanoate, arginine and proline, starch and sucrose, cysteine and methionine, purine, and propanoate metabolism. Moreover, correlation and comprehensive analyses identified a robust association among SDS phenotypes, serum metabolites, fecal metabolites, and microbial genera. In addition, the BZ-FL herb pair and BZ alone exhibited significantly greater regulatory effects on gastrointestinal function-related indicators compared to FL. This study presents initial evidence of the differential and complementary effects of BZ and FL, analyzing their chemical compositions and their influence on water-fluid metabolism and the microbiota-gut-metabolites axis in SDS. These findings reflect the rationality and scientific basis of the compatibility theory. The study identified potential mechanisms of the BZ-FL herb pair in treating SDS, providing a reference for future research and clinical applications.
Publicações recentes
Mast cell mediators in hereditary angioedema.
Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
🥉 Relato de casoPlatelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
📚 EuropePMCmostrando 163
Familial colorectal cancer: risk factors, screening strategies and personalized medicine.
Cancer geneticsReconsidering the LARS score: a cross-sectional descriptive study exploring complementary screening approaches for low anterior resection syndrome.
International journal of colorectal diseaseEffectiveness comparisons of acupoint stimulation therapies for irritable bowel syndrome: A Bayesian network meta‑analysis.
Complementary therapies in medicineHepatic vein angioplasty and stenting in a paediatric patient with Budd-Chiari syndrome secondary to CHAPLE syndrome: is endovascular therapy the answer?
BMJ case reportsDifferential and complementary effects of Baizhu and Fuling on spleen deficiency syndrome by regulating microbiota-gut-metabolite axis.
Phytomedicine : international journal of phytotherapy and phytopharmacologyTreatment of pediatric abdominal pain: what is the evidence?
Expert review of gastroenterology & hepatologyEstablishing and validating syndromic surveillance of gastrointestinal infections using routine emergency department data, Germany, 2019-2023.
Scientific reportsAn Unusual Gastrointestinal Presentation of Sjogren's Syndrome: A Case Report.
Clinical case reportsSmartphone Application With Health Coaching Facilitates Multi-Symptom Improvement in IBS Patients: A Pilot Feasibility Trial.
Neurogastroenterology and motilityChangji'an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway.
BMC complementary medicine and therapiesA rare co-existence of celiac disease and C3 glomerulopathy.
NefrologiaILA mitigates HFD-induced metabolic dysfunction via lipid-immune crosstalk and gut microbiota modulation in zebrafish.
Fish & shellfish immunologyDirect letters to relatives at risk of hereditary cancer-a randomised trial on healthcare-assisted versus family-mediated risk disclosure.
European journal of human genetics : EJHGThe road to Rome IV and beyond: Evolution, refinements and future considerations for the Rome criteria for functional gastrointestinal disorders.
Indian journal of gastroenterology : official journal of the Indian Society of GastroenterologyPolygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk.
JCO precision oncologyComplement dysregulation at lymphatics.
The Journal of allergy and clinical immunology[Sessile serrated lesion with dysplasia and invasion].
Orvosi hetilapComprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker.
Investigative ophthalmology & visual scienceDIAGNOSIS AND TREATMENT OF SMALL INTESTINAL BACTERIAL OVERGROWTH: AN OFFICIAL POSITION PAPER FROM THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY.
Arquivos de gastroenterologiaExploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review.
Complementary therapies in medicinePeripheral GABAA receptors - Physiological relevance and therapeutic implications.
Pharmacology & therapeutics'I Live With Lynch. Cancer Worry Ebbs Into the Background, Then Something Brings It to the Fore.' A Qualitative Interview Study Exploring How Lynch Syndrome Carriers Make Sense of Their Cancer Risks and Implications to Support Decision Making.
Psycho-oncologyUrgency an important factor when assessing fecal incontinence.
Updates in surgeryHow fragile the positive results of Chinese herbal medicine randomized controlled trials on irritable bowel syndrome are?
BMC complementary medicine and therapiesInterplay of yoga, physical activity, and probiotics in irritable bowel syndrome management: A double-blind randomized study.
Complementary therapies in clinical practiceProtein-losing enteropathy as a new phenotype in atypical hemolytic uremic syndrome caused by CD46 gene mutation.
Pediatric nephrology (Berlin, Germany)Intestinal microflora promotes Th2-mediated immunity through NLRP3 in damp and heat environments.
Frontiers in immunologyEffect of the dietary supplement PERMEAPROTECT+ TOLERANCE© on gut permeability in a human co-culture epithelial and immune cells model.
HeliyonClassic paroxysmal nocturnal haemoglobinuria presenting with intestinal malabsorption syndrome, acute abdomen and acute kidney injury.
BMJ case reportsHypnotherapy as a medical treatment: Evidence-based or pseudoscience?
Complementary therapies in clinical practiceIntestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection.
Cell host & microbeATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy.
Genes & developmentAcupuncture as an adjunctive therapy for gastric ulcer: A modified Delphi consensus study.
Complementary therapies in medicineGuardians of Immunity: Advances in Primary Immunodeficiency Disorders and Management.
CureusReduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice.
BMC biologyPlant Polyphenols as Inhibitors of Hydrolases are Regulators of Digestion.
Complementary medicine researchWhere does capsule endoscopy fit in the diagnostic algorithm of small bowel intussusception?
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the LiverAnalysis of gut microbiota in patients with Williams-Beuren Syndrome reveals dysbiosis linked to clinical manifestations.
Scientific reportsClinical efficacy of one-finger meditation massage on IBS-C based on the "gut-brain axis" theory: study protocol for a randomized controlled trial.
BMC complementary medicine and therapiesProtein-losing enteropathy as the first presentation of systemic lupus erythematosus: A case report from Sudan.
Clinical case reportsAntibody response in children with multisystem inflammatory syndrome related to COVID-19 (MIS-C) compared to children with uncomplicated COVID-19.
Frontiers in immunologyQixue Shuangbu decoction and acupuncture combined with Western medicine in acute severe stroke patients.
World journal of clinical casesDescription of novel capsule biosynthesis loci of Campylobacter jejuni clinical isolates from South and South-East Asia.
PloS oneDisease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations.
Journal of autoimmunityA case of systemic lupus erythematosus presenting with intestinal lymphangiectasia-associated protein-losing enteropathy accompanying hyperinflammation.
International journal of rheumatic diseasesObesity Contributes to Inflammation in Patients with IBS via Complement Component 3 and C-Reactive Protein.
NutrientsPreoperative Biologics Exposure Predisposes Ulcerative Colitis Patients to a Distinct Delayed Postoperative Ileus Syndrome After Colectomy.
Medical science monitor : international medical journal of experimental and clinical researchMetastatic colorectal cancer as the primary phenotype in a hereditary breast and ovarian cancer patient with Germline BRCA1 mutation: a case report.
Journal of ovarian researchEffects of Modified Baizhu Shaoyao San on Postoperative Diarrhea in Colorectal Cancer Patients: A Single-Blind, Randomized Controlled Trial.
Complementary medicine researchThe immune response as a therapeutic target in non-alcoholic fatty liver disease.
Frontiers in immunologyFunctional gastrointestinal disorders in children: Effectivity, safety, and tolerability of the herbal preparation STW-5 (Iberogast®) in general practice.
Complementary therapies in medicineIntestinal Injury in Ugandan Children Hospitalized With Malaria.
The Journal of infectious diseasesBiomarkers of Metabolomics in Inflammatory Bowel Disease and Damp-Heat Syndrome: A Preliminary Study.
Evidence-based complementary and alternative medicine : eCAMAssessing the post-treatment therapeutic effect of tongxie in irritable bowel syndrome: A randomized controlled trial.
Complementary therapies in medicineGenomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection.
Proceedings of the National Academy of Sciences of the United States of AmericaCD55-deficiency in Jews of Bukharan descent is caused by the Cromer blood type Dr(a-) variant.
Human geneticsAutologous gastrointestinal reconstruction surgery for short bowel syndrome: the cornerstone for intestinal rehabilitation.
Current opinion in organ transplantationHuangqi-Honghua Combination Prevents Cerebral Infarction with Qi Deficiency and Blood Stasis Syndrome in Rats by the Autophagy Pathway.
Evidence-based complementary and alternative medicine : eCAMJuvenile polyposis diagnosed with an integrated histological, immunohistochemical and molecular approach identifying new SMAD4 pathogenic variants.
Familial cancerMoxibustion for diarrhea-predominant irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials.
Complementary therapies in clinical practiceEx vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.
Molecular therapy : the journal of the American Society of Gene TherapyAn enriched environment reduces chronic stress-induced visceral pain through modulating microglial activity in the central nucleus of the amygdala.
American journal of physiology. Gastrointestinal and liver physiologyDDX3X and DDX3Y are redundant in protein synthesis.
RNA (New York, N.Y.)Complement and the prothrombotic state.
BloodEffects of yoga in inflammatory bowel diseases and on frequent IBD-associated extraintestinal symptoms like fatigue and depression.
Complementary therapies in clinical practiceAntihyperuricemic Effect of Dendropanax morbifera Leaf Extract in Rodent Models.
Evidence-based complementary and alternative medicine : eCAMAtypical HUS and Crohn's disease-interference of intestinal disease activity with complement-blocking treatment.
Pediatric nephrology (Berlin, Germany)Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors.
International journal of molecular sciencesDietary Practices of Women with Endometriosis: A Cross-Sectional Survey.
Journal of alternative and complementary medicine (New York, N.Y.)Intestinal Abnormalities in Patients With SARS-CoV-2 Infection: Histopathologic Changes Reflect Mechanisms of Disease.
The American journal of surgical pathologyDistinct clinical and genetic mutation characteristics in sporadic and Lynch syndrome-associated endometrial cancer in a Chinese population.
Cancer epidemiologyAmygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model.
American journal of physiology. Gastrointestinal and liver physiologyThe effect of pro/synbiotics on postoperative infections in colorectal cancer patients: A systematic review and meta-analysis.
Complementary therapies in clinical practiceWritten expressive disclosure in adults with irritable bowel syndrome: A randomized controlled trial.
Complementary therapies in clinical practiceMulti-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice.
Journal of cachexia, sarcopenia and muscleSystematic review, meta-analysis with subgroup analysis of hypnotherapy for irritable bowel syndrome, effect of intervention characteristics.
Complementary therapies in medicineEfficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study.
BMC complementary medicine and therapiesPractitioners' experiences of using Gut Directed Hypnosis for irritable bowel syndrome: Perceived impact upon client wellbeing: A qualitative study.
Complementary therapies in medicineThe Gut Barrier, Intestinal Microbiota, and Liver Disease: Molecular Mechanisms and Strategies to Manage.
International journal of molecular sciencesAlternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review.
Journal of alternative and complementary medicine (New York, N.Y.)Patterns of Mycobacterium avium-intracellulare complex infection in duodenal endoscopic biopsies in HIV/AIDS patients.
Annals of diagnostic pathologyA systematic review of Tuina for irritable bowel syndrome: Recommendations for future trials.
Complementary therapies in medicineGinger relieves intestinal hypersensitivity of diarrhea predominant irritable bowel syndrome by inhibiting proinflammatory reaction.
BMC complementary medicine and therapiesUnique genomic and neoepitope landscapes across tumors: a study across time, tissues, and space within a single lynch syndrome patient.
Scientific reportsNow Trending: Using Google Trends to Complement Traditional Epidemiological Methods Used for IBS Research.
Digestive diseases and sciencesNeonatal thrombotic microangiopathy secondary to factor I variant with Hirschsprung disease.
Journal of nephrologyUtilizing Google Trends to Assess Worldwide Interest in Irritable Bowel Syndrome and Commonly Associated Treatments.
Digestive diseases and sciencesMind-body treatments of irritable bowel syndrome symptoms: An updated meta-analysis.
Behaviour research and therapyVitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial.
Complementary medicine researchEffects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial.
Complementary therapies in medicineTranslational Advances in Pediatric Nutrition and Gastroenterology: New Insights from Pig Models.
Annual review of animal biosciencesWestern herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
Complementary therapies in medicineEndocannabinoid system in irritable bowel syndrome and cannabis as a therapy.
Complementary therapies in medicineInsights into the pathogenesis of catastrophic antiphospholipid syndrome. A case report of relapsing catastrophic antiphospholipid syndrome and review of the literature on ischemic colitis.
Clinical rheumatologyVitamin D in inflammatory bowel disease: From biology to clinical implications.
Complementary therapies in medicineTong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways.
BMC complementary and alternative medicineEculizumab treatment of thrombotic microangiopathy in a patient with ulcerative colitis.
Clinical journal of gastroenterologyIntestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction.
Mucosal immunologyIntestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.
ImmunityAn Unusual Case of Clostridium Difficile Colitis and Hemolytic Uremic Syndrome in a Teenager.
South Dakota medicine : the journal of the South Dakota State Medical AssociationEfficacy and safety of Achillea wilhelmsii C. Koch capsules on symptom severity and quality of life in patients with irritable bowel syndrome: a randomized, placebo-controlled clinical trial.
Journal of complementary & integrative medicineEffects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model.
BMC complementary and alternative medicineAtypical hemolytic uremic syndrome in a patient with protein-losing enteropathy.
The Journal of international medical researchHow do people with refractory irritable bowel syndrome perceive hypnotherapy?: Qualitative study.
Complementary therapies in medicineAssessment of the effect of sachet formulation of almond (Amygdalus dulcis L.) on diarrhea prominent irritable bowel syndrome (IBS-D) symptoms: A clinical trial.
Complementary therapies in medicineThe Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders.
Evidence-based complementary and alternative medicine : eCAMAn open-label randomized pragmatic non-inferiority pilot trial to compare the effectiveness of Dysentery compound with individualized homeopathic medicines in irritable bowel syndrome.
Journal of complementary & integrative medicineHaemolytic uraemic syndrome associated with non shiga toxin-producing Escherichia coli bacteraemia: a case report.
BMC nephrologyProbiotics, prebiotics, and low FODMAP diet for irritable bowel syndrome - What is the current evidence?
Complementary therapies in medicineThe impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.
BMC complementary and alternative medicineDietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study.
BMC complementary and alternative medicineCHAPLE syndrome uncovers the primary role of complement in a familial form of Waldmann's disease.
Immunological reviewsHemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.
Acta bio-medica : Atenei ParmensisAn integrative review of dietetic and naturopathic approaches to functional bowel disorders.
Complementary therapies in medicineSevere necrotizing myositis associated with long term anti-neoplastic efficacy following nivolumab plus ipilimumab combination therapy.
Clinical rheumatologyEvaluation of the effect of Lactobacillus reuteri V3401 on biomarkers of inflammation, cardiovascular risk and liver steatosis in obese adults with metabolic syndrome: a randomized clinical trial (PROSIR).
BMC complementary and alternative medicineNew insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats.
HaematologicaEculizumab Is Safe and Effective as a Long-term Treatment for Protein-losing Enteropathy Due to CD55 Deficiency.
Journal of pediatric gastroenterology and nutritionAre personalized tongxie formula based on diagnostic analyses more effective in reducing IBS symptoms?-A randomized controlled trial.
Complementary therapies in medicineNaturopathic Approaches to Irritable Bowel Syndrome-A Delphi Study.
Journal of alternative and complementary medicine (New York, N.Y.)Reduced Symptoms of Post-Traumatic Stress Disorder and Irritable Bowel Syndrome Following Mindfulness-Based Stress Reduction Among Veterans.
Journal of alternative and complementary medicine (New York, N.Y.)Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
European journal of cancer (Oxford, England : 1990)Donor-Specific Antibodies in Pediatric Intestinal and Multivisceral Transplantation: The Role of Liver and Human Leukocyte Antigen Mismatching.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society[Twenty-year follow-up study of antiglycolipid antibodies and electrophysiological findings in a 36-year-old patient with an axonal variant of Guillain-Barré syndrome].
Rinsho shinkeigaku = Clinical neurologyUlcerative Colitis and Atypical Hemolytic-Uremic Syndrome: An Unusual But Potentially Life-threatening Complication.
Inflammatory bowel diseasesA methodological framework for the evaluation of syndromic surveillance systems: a case study of England.
BMC public healthProtease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.
PloS onePlasma metabolic profiling on postoperative colorectal cancer patients with different traditional Chinese medicine syndromes.
Complementary therapies in medicineEchocardiography in functional midgut neuroendocrine tumors: When and how often.
Reviews in endocrine & metabolic disordersAAPT Diagnostic Criteria for Chronic Abdominal, Pelvic, and Urogenital Pain: Irritable Bowel Syndrome.
The journal of painSevere intestinal dysbiosis is prevalent in primary Sjögren's syndrome and is associated with systemic disease activity.
Arthritis research & therapy[Hemolytic and uremic syndrome and related thrombotic microangiopathies: Treatment and prognosis].
La Revue de medecine interneCase Study of Homeopathic Bowel Nosode Remedies for Dysbiotic Japanese Patients.
Journal of alternative and complementary medicine (New York, N.Y.)CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis.
The New England journal of medicineSuccessful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.
Journal of alternative and complementary medicine (New York, N.Y.)[Homöopathisch-phytotherapeutische Behandlung des Reizdarmsyndroms mit Magen-Darm-Entoxin N®: Eine Anwendungsbeobachtung].
Complementary medicine researchAGO Austria recommendation on screening and diagnosis of Lynch syndrome (LS).
Archives of gynecology and obstetricsEculizumab in secondary atypical haemolytic uraemic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationManaging irritable bowel syndrome: The impact of micro-physiotherapy.
Journal of complementary & integrative medicinePrenatal diagnosis and outcome of fetal gastrointestinal obstruction.
Journal of pediatric surgeryDiagnostic Utility of Complement Immunohistochemical Studies in Post-Stem Cell Transplant Intestinal Thrombotic Microangiopathy: Case Report.
Journal of pediatric hematology/oncology36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Critical care (London, England)Moxibustion treatment for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized controlled trial.
BMC complementary and alternative medicineRefractory Depression, Fatigue, Irritable Bowel Syndrome, and Chronic Pain: A Functional Medicine Case Report.
The Permanente journalA Systematic Review on Sasang Constitutional Type-Associated Susceptibility to Disorders in Korea.
Journal of alternative and complementary medicine (New York, N.Y.)Management of short bowel syndrome in postoperative very low birth weight infants.
Seminars in fetal & neonatal medicineProgress in Our Understanding of the Gut Microbiome: Implications for the Clinician.
Current gastroenterology reportsComplement component 6 deficiency increases susceptibility to dextran sulfate sodium-induced murine colitis.
ImmunobiologyExtrarenal Manifestations in Shigatoxin-associated Haemolytic Uremic Syndrome.
Klinische PadiatrieEfficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial.
Complementary therapies in medicineRNA-seq analysis of early enteromyxosis in turbot (Scophthalmus maximus): new insights into parasite invasion and immune evasion strategies.
International journal for parasitologyThe Mexican consensus on irritable bowel syndrome.
Revista de gastroenterologia de MexicoActivation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo.
PloS oneA Hispanic female patient with heartburn: A rare presentation of Paroxysmal Nocturnal Hemoglobinuria.
Boletin de la Asociacion Medica de Puerto RicoSelf-Medication of Somatic and Psychiatric Conditions Using Botanical Marijuana.
Journal of psychoactive drugs"Ninjinto" (Ginseng Decoction), a Traditional Japanese Herbal Medicine, Improves Gastrointestinal Symptoms and Immune Competence in Patients with Chronic Intestinal Failure.
Evidence-based complementary and alternative medicine : eCAMElectro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS).
BMC complementary and alternative medicineCardiac and skeletal muscles show molecularly distinct responses to cancer cachexia.
Physiological genomicsPharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Plant foods for human nutrition (Dordrecht, Netherlands)Teduglutide-Stimulated Intestinal Adaptation Is Complemented and Synergistically Enhanced by Partial Enteral Nutrition in a Neonatal Piglet Model of Short Bowel Syndrome.
JPEN. Journal of parenteral and enteral nutritionExperiences of healing therapy in patients with irritable bowel syndrome and inflammatory bowel disease.
BMC complementary and alternative medicineGastroenterology issues in schizophrenia: why the gut matters.
Current psychiatry reportsThe networks of human gut microbe-metabolite associations are different between health and irritable bowel syndrome.
The ISME journalAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Síndrome de hiperativação do complemento-trombose angiopática-enteropatia com perda de proteína.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Síndrome de hiperativação do complemento-trombose angiopática-enteropatia com perda de proteína
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Hepatic vein angioplasty and stenting in a paediatric patient with Budd-Chiari syndrome secondary to CHAPLE syndrome: is endovascular therapy the answer?
- Familial colorectal cancer: risk factors, screening strategies and personalized medicine.
- Reconsidering the LARS score: a cross-sectional descriptive study exploring complementary screening approaches for low anterior resection syndrome.
- Effectiveness comparisons of acupoint stimulation therapies for irritable bowel syndrome: A Bayesian network meta‑analysis.
- Differential and complementary effects of Baizhu and Fuling on spleen deficiency syndrome by regulating microbiota-gut-metabolite axis.Phytomedicine : international journal of phytotherapy and phytopharmacology· 2026· PMID 41435605mais citado
- Mast cell mediators in hereditary angioedema.
- Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
- Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
- The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
- Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:566175(Orphanet)
- OMIM OMIM:226300(OMIM)
- MONDO:0009174(MONDO)
- GARD:15003(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55647681(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar