Raras
Buscar doenças, sintomas, genes...
Síndrome do intestino curto
ORPHA:104008CID-10 · K91.8CID-11 · DA96.04DOENÇA RARA

A síndrome do intestino curto é uma condição em que o intestino não consegue funcionar direito, seja por um problema de nascença, por falta de circulação sanguínea em alguma parte do intestino ou pela retirada cirúrgica de uma parte grande do trato intestinal. Isso resulta em um intestino delgado funcional com menos de 200 centímetros de comprimento e se manifesta com diarreia, dificuldade para absorver nutrientes, dilatação do intestino e problemas na sua movimentação.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A síndrome do intestino curto é uma condição em que o intestino não consegue funcionar direito, seja por um problema de nascença, por falta de circulação sanguínea em alguma parte do intestino ou pela retirada cirúrgica de uma parte grande do trato intestinal. Isso resulta em um intestino delgado funcional com menos de 200 centímetros de comprimento e se manifesta com diarreia, dificuldade para absorver nutrientes, dilatação do intestino e problemas na sua movimentação.

Pesquisas ativas
27 ensaios
157 total registrados no ClinicalTrials.gov
Publicações científicas
4.419 artigos
Último publicado: 2026 Apr 15

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 100 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
2.0
Europe
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: K91.8
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
10 sintomas
📏
Crescimento
4 sintomas
🩸
Sangue
4 sintomas
🫘
Rins
1 sintomas
🦴
Ossos e articulações
1 sintomas

+ 12 sintomas em outras categorias

Características mais comuns

Má absorção
Anormalidade do intestino delgado
Constipação
Hipotireoidismo central
Atraso de crescimento
Gastrosquise
32sintomas
Sem dados (32)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 32 características clínicas mais associadas, ordenadas por frequência.

Má absorçãoMalabsorption
Anormalidade do intestino delgadoAbnormality of the small intestine
ConstipaçãoConstipation
Hipotireoidismo centralCentral hypothyroidism
Atraso de crescimentoGrowth delay

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico4.419PubMed
Últimos 10 anos200publicações
Pico2025123 papers
Linha do tempo
2026Hoje · 2026🧪 1990Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 35
2Fase 22
1Fase 12
·Pré-clínico11
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome do intestino curto

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

18 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07197944 · Efficacy And Safety Evaluation of Glepaglutide in Treatment …Recrutando
PHASE3
NCT07319832 · A Study of Teduglutide in Chinese Children and Teenagers Wit…Recrutando
NCT06512584 · Efficacy and Safety of PJ009 in Patients With Short Bowel Sy…Recrutando
PHASE3
NCT06771505 · SBS DISK- Creation of a Quality of Life Tool for Short Bowel…Recrutando
NCT06326645 · Open-Label Pilot Study With Crofelemer in Patients With Shor…Recrutando
EARLY_PHASE1
NCT07400783 · TED_ORG: Study on Short Bowel SyndromeRecrutando
NA
NCT05561647 · A Survey to Assess Participants' and Physicians' Knowledge W…Recrutando
NCT03530852 · A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORBRecrutando
NA
NCT04775706 · Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglu…Recrutando
PHASE2
NCT05535361 · A Feasibility Study to Evaluate Safety and Probable Benefit …Recrutando
NA
NCT06973304 · A Study of Teduglutide in Chinese Adults With Short Bowel Sy…Recrutando
PHASE3
NCT06904872 · Safety and Efficacy of Crofelemer in Adult Patients With Sho…Recrutando
PHASE2
NCT01793168 · Rare Disease Patient Registry & Natural History Study - Coor…Recrutando
NCT05302531 · Absorption of Antibiotics With High Oral Bioavailability in …Recrutando
PHASE1
NCT07228403 · Efficacy and Safety Evaluation of Glepaglutide in Treatment …Por convite
PHASE3
NCT06938542 · Palliative Care Needs of Children With Rare Diseases and The…Por convite
NA
NCT05635747 · A 90 Day Observational Study as an Extension to the Phase 3,…Por convite
NCT06240065 · Successful Fiber Food Introduction in Short Bowel SyndromePor convite
NA

Outros ensaios clínicos

157 ensaios clínicos encontrados, 27 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.993 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.993

#1

Glucagon-like peptide agonists and use in short bowel syndrome - what about the side effects?

Current opinion in gastroenterology2026 Mar 23

This review summarizes recent evidence on the use of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) agonists in the management of short bowel syndrome (SBS), with a focus on emerging therapies and real-world experience. It evaluates their impact on intestinal adaptation, safety, and future clinical potential. GLP-2 agonists such as teduglutide continue to demonstrate improvements in intestinal absorption resulting in reductions in parenteral support (PS) requirements and improved quality of life. Clinical trials report that newer long-acting agents, such as apraglutide and glepaglutide, allow less frequent dosing with a reduction in PS and structural intestinal changes on imaging. Safety profiles remain favourable, with gastrointestinal symptoms, fluid balance issues, gallbladder events and injection-site reactions reported most frequently. GLP-1 agonists show promise in slowing transit time and offer an area for further research. While GLP-2 agonists shape the current landscape of SBS management, GLP-1 based therapies may complement future treatment strategies offering the potential to reduce or even eliminate dependence on PS. Continued long-term studies and registry data are essential to optimize patient selection, safety monitoring, and personalized use of GLP agonists.

#2

Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutide.

Journal of pediatric gastroenterology and nutrition2026 Mar 19

The complex care needs of pediatric patients with short bowel syndrome-associated intestinal failure (SBS-IF) can negatively impact the health-related quality of life (HRQoL) of patients and their caregivers. We assessed the impact of teduglutide on HRQoL of pediatric patients with SBS-IF. Two long-term extension (LTE) studies (NCT02949362, NCT02954458) assessed HRQoL over 96 weeks using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL Family Impact Module. Patients included in this analysis received teduglutide in one of three randomized Phase 3 parent studies and the respective LTE study. We assessed changes in HRQoL over time, as well as the impact of attaining enteral autonomy on HRQoL and predictors of change in HRQoL. In pediatric patients with SBS-IF receiving teduglutide (n = 69), the total mean (standard deviation) patient-reported PedsQL score was 75.0 (16.2). Higher mean number of stools per day at LTE study baseline (p = 0.03) predicted increased patient-reported HRQoL. Longer teduglutide exposure (p = 0.047), increasing length of remnant small intestine (p = 0.034), and older age (p = 0.026) predicted higher caregiver-proxy-reported HRQoL. Mean PedsQL scores remained stable over 96 weeks regardless of patients achieving enteral autonomy. HRQoL of pediatric patients with SBS-IF treated with teduglutide was generally stable over 96 weeks. Predictors of improved HRQoL included higher baseline stool number, longer teduglutide treatment duration, greater length of small intestine, and older age. To better understand these observations, future studies should assess HRQoL before initiation of treatment.

#3

Fecal microbiota transplantation in murine models of colitis and short bowel syndrome: lessons learned, limitations, and translational perspectives.

Minerva gastroenterology2026 Mar

Fecal microbiota transplantation (FMT) has become a powerful experimental tool for dissecting microbiota-driven mechanisms in murine models of gastrointestinal and systemic disease. This review provides a comprehensive methodological and translational overview of FMT in mice, focusing on lessons learned from inflammatory bowel disease (IBD) research and emerging perspectives in short bowel syndrome (SBS). We first outline the fundamental role of the gut microbiota in immune regulation, metabolic homeostasis, and maintenance of epithelial barrier integrity, establishing the rationale for modulating microbial communities through FMT. A detailed methodological analysis follows, highlighting how donor selection, recipient conditioning, sample handling, administration route, and environmental variables critically influence microbial engraftment and experimental reproducibility. The review then synthesizes current evidence from key murine IBD models, demonstrating that FMT can restore epithelial integrity, rebalance adaptive immunity, modulate cytokine networks, and enrich beneficial short-chain fatty-acid-producing taxa. Concepts such as functional engraftment, viability of transferred communities, and host-microbe metabolic interactions are discussed as central determinants of FMT efficacy. Finally, we address the emerging but challenging application of FMT in SBS. Profound alterations in intestinal anatomy, transit, oxygen tension, and substrate availability limit the integration of donor microbiota in SBS models, necessitating adapted strategies such as anaerobic handling, pre-conditioned consortia, synbiotics, and optimized delivery systems. Piglet models and computational approaches for donor-recipient matching are highlighted as promising translational tools. Overall, this review underscores the need for methodological standardization and physiologically tailored approaches to advance the reliability, mechanistic insight, and translational potential of FMT in both IBD and SBS.

#4

Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.

International journal of molecular sciences2026 Feb 24

Short bowel syndrome (SBS) develops when the remaining intestine is unable to sustain adequate nutrient and electrolyte absorption following extensive bowel resection. The condition is characterized by malabsorption and significant fluid losses which lead to dehydration and progressive weight loss, thus promoting patient dependence on parenteral fluids or nutrition. After an initial acute phase marked by accelerated intestinal transit and gastric hypersecretion, long-term clinical outcomes are largely determined by the capacity of the remaining bowel for intestinal adaptation-a sustained process of structural, functional, and molecular remodeling that enhances absorptive efficiency and restores fluid and nutrient homeostasis. This review summarizes the key histological and cellular features of the adaptive response, including crypt and villus remodeling, mucosal hyperplasia, and smooth muscle hypertrophy, and integrates emerging concepts in crypt biology that define the dynamic cross-talk between intestinal stem cells and the mesenchymal niche, together with their upstream regulatory pathways.

#5

Short bowel syndrome-associated intestinal failure: diagnosis and prognosis.

Expert review of gastroenterology &amp; hepatology2026 Mar 17

Short bowel syndrome is characterized by severe intestinal malabsorption of macronutrients, micronutrients, fluid, and electrolytes. As such, short bowel syndrome often results in permanent need of parenteral support, that is, intestinal failure. To optimize patient outcomes, it is important to establish precise definitions of short bowel syndrome and intestinal failure. Classifying those with SBS can provide useful prognostic, risk and therapeutic implications. This narrative review will focus on the diagnosis and prognosis of this rare condition. A literature search was performed utilizing PubMed and reviewed references from applicable manuscripts primarily between 2000 and September 2025. Short bowel syndrome in adults is a clinical malabsorptive syndrome associated with having <200 cm of residual small bowel in continuity, measured from the duodenojejunal flexure. Intestinal failure is the reduction of gut function below the minimum required for the absorption of macronutrients and/or water and electrolytes, thereby requiring parenteral support to maintain health and/or growth. The remaining small bowel length and segment, and health of the remnant bowel have important prognostic implications. Care gaps exist regarding the diagnosis and management of this condition and future efforts should address these disparities in order to provide optimal care to these patients.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.998 artigos no totalmostrando 200

2026

Endoscopic Creation of an Internal Enterocolonic Fistula for a Noncommunicating Bowel Loop: A Novel Minimally Invasive Approach.

ACG case reports journal
2026

Short Bowel Syndrome: Adaptive Mechanisms and Management Strategies in Veterinary Patients.

The Veterinary clinics of North America. Small animal practice
2026

Corrigendum to "Smooth muscle cell (SMC) Specific SNRK deletion in mouse causes congenital short bowel syndrome and premature death" [Biochem. Biophys. Rep. 44 (2025) 102298].

Biochemistry and biophysics reports
2026

Glucagon-like peptide agonists and use in short bowel syndrome - what about the side effects?

Current opinion in gastroenterology
2026

Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutide.

Journal of pediatric gastroenterology and nutrition
2026

[Chinese expert consensus on diagnosis and treatment of short bowel syndrome in adults (2026 version)].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
2026

Fecal microbiota transplantation in murine models of colitis and short bowel syndrome: lessons learned, limitations, and translational perspectives.

Minerva gastroenterology
2026

Teduglutide use in haemodialysis-dependent renal failure from secondary hyperoxaluria in short bowel syndrome and type 3 intestinal failure - A case report.

Intestinal Failure (New York, N.Y.)
2026

Crossing borders with parenteral nutrition: A pediatric case of international travel on home parenteral nutrition.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2026

Spontaneous transanal evisceration of the small bowel through perforation of the sigmoid colon: a case report and new surgical approach.

International journal of surgery case reports
2026

Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.

International journal of molecular sciences
2026

Effectiveness and Safety of Teduglutide Treatment in Adult Patients with Short Bowel Syndrome: A Case Series and Review of Current Evidence.

Journal of clinical medicine
2026

Small Intestine and Vermiform Appendix Lengths in Healthy Adults: Intraoperative Morphometric Data from a Living Donor Cohort.

Journal of clinical medicine
2026

Short bowel syndrome-associated intestinal failure: diagnosis and prognosis.

Expert review of gastroenterology &amp; hepatology
2026

Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.

Annals of surgical treatment and research
2026

Exploring the disease burden and quality of life in patients with short bowel syndrome with intestinal failure: Insights from exit interviews in the glepaglutide EASE SBS-1 phase 3 trial.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2026

Real-world effectiveness and safety of teduglutide in patients with short bowel syndrome.

World journal of gastrointestinal pharmacology and therapeutics
2026

Quality of life of children with short bowel syndrome and their caregivers from the perspective of caregivers: a cross-sectional study in China.

European journal of pediatrics
2026

A Gut-Restricted Liver X Receptor Agonist Ameliorates Liver Injury in Experimental Short Bowel Syndrome.

Gastroenterology
2026

Surgical reconstruction in a 100-year-old patient with short bowel syndrome under palliative care: A case report.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2026

Care transition from a pediatric intestinal rehabilitation program to adult care and the risk of all-cause mortality: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition
2026

Investigation of the stool microbiome of short bowel syndrome patients before and after a 24-week treatment with the glucagon-like peptide 2 analog glepaglutide.

Clinical nutrition ESPEN
2026

Rivaroxaban vs. apixaban in short bowel syndrome: a focused clinical pharmacology review.

Expert opinion on drug metabolism &amp; toxicology
2026

Retrospective Evaluation of Central Venous Catheter Use for Parenteral Nutrition in Pediatric Intestinal Failure: Infections and Taurolidine Role.

Antibiotics (Basel, Switzerland)
2026

Contemporary challenges and outcomes in children with ultrashort bowel syndrome: A descriptive cohort study.

Journal of pediatric gastroenterology and nutrition
2026

Pilot trial: 8.4% sodium bicarbonate locks for infection prevention in pediatric intestinal failure.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2026

An exploratory in vitro co-culture of enteric neurons and smooth muscle cells demonstrates neuronal contribution to muscle layer formation.

Scientific reports
2026

Placental extracellular vesicles stimulate intestinal re-growth after massive small bowel resection in a rat model.

Pediatric surgery international
2026

Massive Small Bowel Resection Induces IFALD-Like Liver Injury in Mice.

Yonago acta medica
2025

An Alternative Route for the Treatment of Hypothyroidism in Neonates with Intestinal Disorders: Buccal Administration of Levothyroxine.

Sisli Etfal Hastanesi tip bulteni
2026

Interpreting pooled GLP-2 analogue effects in chronic intestinal failure transparency, attrition, and real-world generalisability.

Clinical nutrition ESPEN
2026

Thiamine Use in Hospitalized Patients: A Clinical Review.

Journal of nutrition and metabolism
2026

[Use of teduglutide in short bowel syndrome in infants, children and adolescents: Position paper of the working group "Chronic intestinal failure" of the Society for Paediatric Gastroenterology and Nutrition (GPGE)].

Zeitschrift fur Gastroenterologie
2026

Updates on intestinal failure management.

Expert review of gastroenterology &amp; hepatology
2026

Double-balloon enteroscopy evaluation and surveillance in patients with short bowel syndrome.

Therapeutic advances in gastroenterology
2026

Hyperinsulinemia After Extensive Small Bowel Resection and Total Parenteral Nutrition in a Neonate: A Case Study.

Nutrition and metabolic insights
2026

Digestible and Metabolizable Energy Intake in Humans: a Systematic Review.

Advances in nutrition (Bethesda, Md.)
2026

Treatment Outcomes of Short Bowel Syndrome in Paediatric Patients.

Journal of paediatrics and child health
2026

Efficacy of autologous intestinal reconstruction surgery on bowel dilatation in pediatric small bowel syndrome.

Journal of pediatric surgery
2025

Long term outcomes of no gut syndrome in children - A multicentre study.

Intestinal Failure (New York, N.Y.)
2025

Incidence, predictors and outcome of neonatal-onset intestinal failure.

Intestinal Failure (New York, N.Y.)
2025

Measuring disease-specific quality of life in pediatric intestinal failure: Development and validation of the PIF-QoL.

Intestinal Failure (New York, N.Y.)
2025

Epidemiology of US patients with short bowel syndrome-associated intestinal failure: A claims database analysis.

Intestinal Failure (New York, N.Y.)
2025

The current state of paediatric intestinal transplantation: A global review.

Intestinal Failure (New York, N.Y.)
2024

Perspectives of intestinal rehabilitation providers on the use of oral rehydration solutions for pediatric patients with short bowel syndrome.

Intestinal Failure (New York, N.Y.)
2024

Development of a registry to evaluate immobilized lipase cartridge use in pediatric patients with short bowel syndrome/intestinal failure.

Intestinal Failure (New York, N.Y.)
2024

The medical benefits of fully integrated intestinal rehabilitation psychology: A case report.

Intestinal Failure (New York, N.Y.)
2025

Prevalence of sarcopenia in patients with chronic intestinal failure due to short bowel syndrome.

Intestinal Failure (New York, N.Y.)
2024

A comparison of chyme reinfusion therapy methods: Two case studies.

Intestinal Failure (New York, N.Y.)
2024

Pharmacologic challenges in pediatric intestinal failure: A review.

Intestinal Failure (New York, N.Y.)
2024

Exploring the role of pancreatic enzyme replacement therapy in patients with short bowel syndrome: Nutritional and Anthropometric Outcomes.

Intestinal Failure (New York, N.Y.)
2026

Primary Repair of a Jejunal Atresia With Christmas Tree Deformity in a Preterm Infant.

Clinical case reports
2026

A Case of Late Radiation-Induced Enteritis with Enterolith Caused Enterocutaneous Fistula.

Surgical case reports
2026

Real-World Evidence of Growth Improvement in Children 1 to 5 Years of Age Receiving Enteral Formula Administered Through an Immobilized Lipase Cartridge.

Nutrients
2026

Nutritional Strategies for Intestinal Rehabilitation in Children with Short Bowel Syndrome: A Narrative Review.

Nutrients
2026

Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.

Journal of clinical medicine
2026

Letter in reference to the recent article: "Absorption and anticoagulant management of rivaroxaban in patients with short bowel syndrome" by Lunau et al.

Thrombosis research
2026

Vitamin K in home parenteral nutrition: Is it really necessary?

Endocrinologia, diabetes y nutricion
2026

Conceptual and operational consistency in defining intestinal failure across randomized controlled trials: a systematic review and meta-research analysis.

BMC gastroenterology
2025

Case Report: genotype-phenotype correlations in FLNA mutations: insights from a case of multisystem dysfunction.

Frontiers in genetics
2025

Entirely Right-Sided Colon: A Case Report.

Cureus
2025

Real-world efficacy of long-term teduglutide use in pediatric patients with short bowel syndrome.

Intestinal Failure (New York, N.Y.)
2026

Growth failure and early recurrence in congenital diaphragmatic hernia: An international cohort study.

Journal of pediatric surgery
2026

Pharmacokinetics and Safety of Single-Dose Apraglutide in Individuals with Normal and Impaired Hepatic Function: A Phase 1, Open-Label Trial.

Clinical pharmacology in drug development
2026

Qualitative Research for the Development of Three New Quality of Life and Treatment Impact Questionnaires for Adults with Short Bowel Syndrome with Intestinal Failure (SBS-IF).

Digestive diseases and sciences
2026

Malabsorption Syndromes and Risk of Age-Related Macular Degeneration.

Ophthalmology. Retina
2026

Oral rehydration solution for the management of fluid and electrolyte disturbances in patients with an ileostomy: A scoping review.

JPEN. Journal of parenteral and enteral nutrition
2026

Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure. A 20-year retrolective cohort.

PloS one
2025

Impact of teduglutide on pediatric short bowel syndrome: A systematic review and trial sequential meta-analysis.

World journal of gastrointestinal surgery
2025

Effectiveness of Sofosbuvir/Velpatasvir in a patient with ultra-short bowel syndrome and hepatitis C virus infection: A case report.

Gastroenterologia y hepatologia
2025

Symptomatic vitamin A deficiency in a paediatric patient with short bowel syndrome.

BMJ case reports
2026

Niche-preserving transplantation promotes functional engraftment of intestinal organoids in rat short bowel syndrome.

Cell stem cell
2025

Beyond the Bedside: Addressing Structural Gaps in the Care of Undocumented, Seriously Ill Patients.

Journal of palliative medicine
2025

Assessment of liver stiffness and steatosis in patients with intestinal failure: a cross-sectional study.

Frontiers in nutrition
2025

Sclerotherapy as first-line treatment of rectal prolapse in children, including those with anorectal malformations.

Pediatric surgery international
2026

Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open-label study.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Planned Relook Laparotomy for the Salvage of Extensive Small Bowel Ischemia in Primary Volvulus: A Case Report From a Resource-Limited Setting.

Cureus
2025

Glucagon-Like Peptide-2 (GLP-2) Analogues in Patients With Short Bowel Syndrome Dependent on Parenteral Support: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JGH open : an open access journal of gastroenterology and hepatology
2025

Oral nutritional management in short bowel syndrome.

Best practice &amp; research. Clinical gastroenterology
2026

Epithelial ion transport in spring-lengthened jejunum in a porcine model.

Journal of pediatric surgery
2026

GLP-2 analogues in short bowel syndrome: A systematic review and meta-analysis of randomized controlled trials.

Clinical nutrition ESPEN
2025

Development of a predictive model for severe adverse outcomes following surgery for neonatal necrotizing enterocolitis: a nomogram study based on postoperative intestinal failure beyond 42 days and death.

Frontiers in pediatrics
2025

SARS-CoV-2 infection during pregnancy and necrotizing enterocolitis: case report and review of the literature.

Italian journal of pediatrics
2026

Parents' Experiences and Needs in Home Nutritional Management of Children With Short Bowel Syndrome: A Qualitative Study.

Child: care, health and development
2025

Caregiver perspectives on barriers and facilitators to pediatric intestinal failure quality of life.

Intestinal Failure (New York, N.Y.)
2025

Endovascular versus open revascularization for acute arterial occlusive mesenteric ischemia: a retrospective single center analysis.

Langenbeck's archives of surgery
2025

Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina.

World journal of gastrointestinal pharmacology and therapeutics
2025

Epidemiological Characteristics of Pediatric Patients with Intestinal Failure in Spain: Data from the REPAFI Registry.

Nutrients
2025

Liver injury in a preclinical model of short bowel syndrome is associated with impaired autophagy.

Scientific reports
2026

Positive clinical outcomes associated with use of glucagon-like peptide-2 (GLP-2) analogues in patients with intestinal failure: A systematic review and meta-analysis.

Clinical nutrition ESPEN
2025

Advances in research on congenital and hereditary intestinal diseases: From molecular mechanisms to precision medicine.

Intractable &amp; rare diseases research
2025

Staged bowel resection guided by intraoperative indocyanine green fluorescence angiography in the management of acute type a aortic dissection with mesenteric malperfusion: a case report.

Journal of cardiothoracic surgery
2026

Six-Month Safety and Effectiveness of Teduglutide in Patients with Short Bowel Syndrome in Japan: Interim Analysis of Post-marketing Surveillance.

Advances in therapy
2026

3, 2, 1! From GLP-2 to GLP-1 analog over a 10-year journey.

Endocrinologia, diabetes y nutricion
2025

Health State Utility Associated with Parenteral Nutrition Requirement in Patients with Short Bowel Syndrome and Intestinal Failure in Korea: A Vignette-Based Approach.

Nutrients
2025

Small Intestinal Bacterial Overgrowth in Children with Short Bowel Syndrome.

Children (Basel, Switzerland)
2026

From resection to preservation: redefining the surgical paradigm in Crohn's disease.

Journal of Crohn's &amp; colitis
2025

Increased BMI favors weaning in patients with chronic intestinal failure due to short bowel syndrome: a retrospective cohort study in Italy.

Frontiers in nutrition
2025

Predictive value of biomarkers in neonatal necrotizing enterocolitis.

Frontiers in pediatrics
2025

Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy.

Scientific reports
2025

How to rescue a percutaneous gastrostomy tube perforating the jejunum.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy
2025

Oral ethosuximide treatment in a child with short bowel syndrome.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model.

Gastroenterology research and practice
2025

Microbiota decolonization of bacterial pathogens in pediatric surgery-related intestinal disorders: Insights on current strategies and future outlook.

World journal of clinical pediatrics
2025

Delayed presentation of a retained colonic segment in a child with intestinal failure on teduglutide.

JPGN reports
2025

Oxalate nephropathy precipitated by linaclotide in a high-risk patient.

Clinical nephrology. Case studies
2026

The impact of intervention timing, etiology, and revascularization strategy on acute mesenteric ischemia outcomes.

Journal of vascular surgery
2026

Critical Analysis of "Remodelling the Colon With Ileal Properties to Treat Short Bowel Syndrome".

Gastroenterology
2025

Management of Pediatric Intestinal Failure.

Gastroenterology clinics of North America
2025

Diagnosis and Management of Small Intestinal Bacterial Overgrowth in Pediatric Short Bowel Syndrome.

Gastroenterology clinics of North America
2026

Review Article: The Evolving Role of GLP-1 Receptor Agonists in Gastroenterology Practice.

Alimentary pharmacology &amp; therapeutics
2025

Quality of life and healthcare resource utilization among adult patients with short bowel syndrome: A mixed-methods study leveraging an integrated database.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

Idiopathic hypereosinophilic syndrome complicated by computed tomography-negative cerebral infarction, strangulated intestinal obstruction, and hepatic portal venous gas: a case report of multi-system involvement.

Quantitative imaging in medicine and surgery
2026

Artificial intelligence (AI) in nutrition: A case-based comparison of generative AI models.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

The First Case of Liver-Intestine En-Bloc Transplantation in Japan.

Surgical case reports
2026

Development of a consensus parenteral solution weaning algorithm for children with short-bowel syndrome associated intestinal failure responding to teduglutide therapy.

Archives of disease in childhood
2025

Intravenous Lipid Emulsion-Induced Soy Allergy and Atopic Dermatitis in an Infant: A Case Report.

Pediatric allergy, immunology, and pulmonology
2025

Engineering hope: tissue-engineered intestine as a breakthrough for pediatric short bowel syndrome.

Annals of medicine and surgery (2012)
2025

Experience in enteral and parenteral nutrition schemes for familial congenital short bowel syndrome: Two case reports.

World journal of gastrointestinal surgery
2025

Geriatric syndromes in intestinal failure: An accelerated aging phenomenon in middle adulthood patients?

Clinical nutrition ESPEN
2025

Smooth muscle cell (SMC)-Specific SNRK deletion in mouse causes congenital short bowel syndrome and premature death.

Biochemistry and biophysics reports
2025

Mesenteric fibromatosis involving the superior mesenteric vein: complex resection and reconstruction in a young female.

Journal of surgical case reports
2026

Navigating the Prognosis and Functional Recovery of Short Bowel Syndrome: A Mentored Review.

Digestive diseases and sciences
2026

Dysmotility in pediatric short bowel syndrome: Review and commentary.

Journal of pediatric gastroenterology and nutrition
2025

Gastrointestinal tolerance, healthcare resource utilization, and cost analysis of whey peptide-based enteral formula in pediatric post-acute care: A retrospective study.

Clinical nutrition ESPEN
2025

Necrotizing Enterocolitis Due to Mesenteric Artery Thrombosis in a Patient with Craniofrontonasal Dysplasia: Casual or Causal Association?

Journal of clinical medicine
2025

Indocyanine green fluorescence in second-look surgery for necrotizing enterocolitis: enhancing the surgeon's perception.

Frontiers in pediatrics
2025

A single-center experience of home parenteral nutrition for pediatric intestinal failure.

Frontiers in pediatrics
2025

Safety of Teduglutide for Managing Patients with Short Bowel Syndrome: A Systematic Review and Meta-analysis.

Pakistan journal of medical sciences
2025

Does colostrum play a role in intestinal adaptation? A systematic review of literature.

La Pediatria medica e chirurgica : Medical and surgical pediatrics
2025

Infant malrotation with midgut volvulus: A retrospective review of clinical presentation and delays in care at a Canadian tertiary paediatric centre.

Paediatrics &amp; child health
2025

Innovative Approach to Pediatric Peutz-Jeghers Syndrome: Simultaneously Performing Laparoscopic Reduction of Polyp-Induced Intussusception and Polypectomy with Double-Balloon Endoscopy.

Surgical case reports
2025

Pharmacokinetics of apixaban in patients with short bowel syndrome: a Bayesian re-estimation approach.

Expert opinion on drug metabolism &amp; toxicology
2025

Nyctalopia Due to Vitamin A Deficiency Secondary to Short Bowel Syndrome: When the Electroretinogram Is the Diagnostic Key.

Brain sciences
2025

Christmas tree pattern ileal atresia with intestinal malrotation in a 15-day-old infant: A rare dual congenital anomaly in the pediatric population - A case report.

International journal of surgery case reports
2025

Vanishing Gastroschisis: The Importance of Prenatal Diagnosis in a Seemingly Normal Abdomen.

European journal of pediatric surgery reports
2025

Successful pregnancy in a patient with active Crohn's disease, chronic intestinal failure, and long-term parenteral nutrition receiving upadacitinib: A case report.

JPEN. Journal of parenteral and enteral nutrition
2025

Clinical Predictive Factors for the Development of Short Bowel Syndrome in a Cohort of Patients with Crohn's Disease: A Prospective Study.

Journal of clinical medicine
2025

Management of type 1 (acute) intestinal failure.

BMJ open gastroenterology
2025

Do functional gut parameters predict enteral autonomy and chronic cholestasis in pediatric intestinal failure?

Clinical nutrition (Edinburgh, Scotland)
2025

Recurrent Bloodstream Infections Without Sepsis in a Patient With Short Bowel Syndrome on Parenteral Nutrition: A Case of Potential Sepsis Tolerance.

Cureus
2025

Early-onset necrotizing enterocolitis during the initiation of cow's milk formula.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation.

Physiological research
2025

A case of yogurt central line-associated bloodstream infection in a child with intestinal failure.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

A case report on the long-term use of teduglutide in a pediatric patient with short bowel syndrome.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

Multivisceral transplantation as a rescue treatment for intestinal failure following pancreaticoduodenectomy: A case report.

World journal of transplantation
2025

Three-year experience with GLP-2 analog in intestinal rehabilitation for pediatric-onset short bowel syndrome.

Pediatric surgery international
2025

Efficacy of Teduglutide in Pediatric Short Bowel Syndrome: Association with Citrulline Levels and Anatomical Location of Remnant Small Intestine.

Children (Basel, Switzerland)
2026

Development of a novel tubular scaffold for tissue-engineered small intestine.

Journal of pediatric surgery
2025

100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling.

Human cell
2025

A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA.

Frontiers in genetics
2025

Uncommon Ileo-Cecal Intussusception in Adults: A Case Report of Diagnosis and Management.

The American journal of case reports
2025

Mechanical Thrombectomy Using a Balloon Guide Catheter for Acute Occlusion of the Superior Mesenteric Artery.

Journal of vascular and interventional radiology : JVIR
2025

Clinical, biochemical, and molecular findings in adults with hyperammonemia: A French bi-centric retrospective study.

Molecular genetics and metabolism
2025

A Case of Acetaminophen Toxicity in a Patient With an Unusual Alpha-1 Antitrypsin Phenotype.

Cureus
2025

Techniques and procedures for advancing feeds for children with intestinal failure due to short bowel syndrome: A narrative review.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

Alterations in gut microbiota and insights into the colonic function by clodronate: a study using short bowel syndrome rat model.

Pediatric surgery international
2025

A Rare Twist in the Tale: Midgut Volvulus From Intestinal Non-rotation in an Adult.

Cureus
2025

Case Report: A female patient with gastrointestinal perforation, acute diffuse peritonitis, and Crohn's disease needs homeostasis management.

Frontiers in medicine
2025

Incidence of chronic intestinal failure due short bowel syndrome in adults: A feasibility study.

Clinical nutrition ESPEN
2026

Critical Organ Dysfunction in Newborns with Gastroschisis.

American journal of perinatology
2025

Outcomes of glepaglutide on intestinal absorption and parenteral support in patients with short bowel syndrome.

Clinical nutrition ESPEN
2025

Longitudinal single-cell analysis of glucagon-like peptide-2 treatment in patients with short bowel syndrome.

JCI insight
2025

Short bowel syndrome-associated intestinal failure patient experience: A mixed-method study leveraging an online patient community.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2025

Quality of life and lived experience of patients with short bowel syndrome treated with teduglutide and weaning off home parenteral nutrition: a qualitative analysis of patient diaries.

BMJ open gastroenterology
2025

Metastatic esophageal squamous cell carcinoma with paraneoplastic Raynaud phenomenon: a case report.

AME case reports
2025

Surgical and nutritional outcomes of extremely low birth weight infants with enterostomy: a single-center retrospective study in China.

Pediatric surgery international
2025

Long-term antithrombotic therapy practices in adult patients with short bowel syndrome following acute mesenteric ischemia: An international case-based survey.

Clinical nutrition ESPEN
2025

Reduction of Parenteral Nutrition in Children with Short Bowel Syndrome Treated with Teduglutide: Experience from the Czech Republic.

Klinische Padiatrie
2025

Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration.

Bioengineering (Basel, Switzerland)
2025

Small intestinal bacterial overgrowth and dysbiosis in children with intestinal failure: A descriptive cohort study.

JPEN. Journal of parenteral and enteral nutrition
2026

Proglucagon-derived peptides: human physiology and therapeutic potential.

Physiological reviews
2025

Pharmacological Challenges in Short Gut Syndrome and Pain Management: A Case Series and Review of Literature.

Journal of pain &amp; palliative care pharmacotherapy
2025

Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort study.

EClinicalMedicine
2025

Management challenges in a patient presenting with acute mesenteric ischaemia.

BMJ case reports
2025

In Vivo Clinical Evaluation of Human Intestinal Tissue Viability Using a Spectroscopic Method.

The Journal of surgical research
2025

Vesicular nucleotide transporter inhibition via clodronate attenuates intestinal glucose transporter expression in short bowel syndrome rat model: A clear issue to nutritional adaptation.

Journal of pediatric surgery
2025

Absorption and anticoagulant management of rivaroxaban in patients with short bowel syndrome.

Thrombosis research
2025

D-lactic acidosis in short bowel syndrome: are probiotics friend or foe? A case report.

Hong Kong medical journal = Xianggang yi xue za zhi
2025

Geography, genes, and germs: An evolutionary entanglement.

Biomedical journal
2025

Dietary Interventions for Short Bowel Syndrome in Adults.

Nutrients
2025

The Gut's Secret Code: Bowel Microbiota as a Biomarker for Adaptation.

Nutrients
2025

Extreme Short Bowel Syndrome: A Case of Resilience and Recovery From Acute Intestinal Failure.

Cureus
2025

Microbiota dysbiosis and gut-brain axis interactions in short bowel syndrome: A rat model study.

Journal of pediatric surgery
2025

Post-endoscopic fever and infection in paediatric patients with intestinal failure.

Journal of pediatric gastroenterology and nutrition
2025

A comprehensive review of small bowel length measurement: methodological challenges and variability factors.

Progress in biomedical engineering (Bristol, England)
2025

The Challenging Management of Short Bowel Syndrome.

Diagnostics (Basel, Switzerland)
2025

Analysis of risk factors affecting psycho-behavioural development in children with short bowel syndrome.

Pediatric surgery international
2025

Fabrication andin vivocharacterization of FRESH-based 3D printed chitosan construct for small intestine regeneration.

Biomedical materials (Bristol, England)
2025

Chronic Hepatitis C Treatment Failure With Crushed Sofosbuvir/Velpatasvir in a Patient With Total Parenteral Nutrition-dependent Short Bowel Syndrome.

Journal of pharmacy practice
2025

Parenteral nutrition weaning in pediatric intestinal failure patients enrolled in remote patient monitoring: A descriptive study.

JPEN. Journal of parenteral and enteral nutrition
2025

Glepaglutide in Short Bowel Syndrome: Promising, But Questions Remain.

Gastroenterology
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Personalized Dosing Strategies: The Missing Link in Glepaglutide Therapy for Short Bowel Syndrome.

Gastroenterology
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Teduglutide in adults with short bowel syndrome and intestinal failure: A descriptive cohort study.

JPEN. Journal of parenteral and enteral nutrition
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Ten-Year-Old Girl With Emesis, Abdominal Distention, Tenderness, Altered Mental Status, and Ataxia.

Pediatrics
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Copper Deficiency Presenting With Bicytopenia During Long-Term Parenteral Nutrition for Short Bowel Syndrome: A Case Report and Literature Review.

Cureus
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Precision grading of surgical strategies for small bowel Crohn's disease: An R0-R3 individualized framework based on lesion severity and functional preservation.

Intractable &amp; rare diseases research
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Small Intestinal Strangulation Secondary to Omental Adhesion Entrapment in a Dog.

Case reports in veterinary medicine
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Association between multioil intravenous lipid emulsion and cholestasis in infants with gastrointestinal disorders: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition
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[Treatment for Intestinal Failure/Short Bowel Syndrome: Alternatives to Small Bowel Transplantation - What is the International Standard?].

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Glucagon-like peptide agonists and use in short bowel syndrome - what about the side effects?
    Current opinion in gastroenterology· 2026· PMID 41866997mais citado
  2. Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutide.
    Journal of pediatric gastroenterology and nutrition· 2026· PMID 41858082mais citado
  3. Fecal microbiota transplantation in murine models of colitis and short bowel syndrome: lessons learned, limitations, and translational perspectives.
    Minerva gastroenterology· 2026· PMID 41854281mais citado
  4. Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.
    International journal of molecular sciences· 2026· PMID 41828334mais citado
  5. Short bowel syndrome-associated intestinal failure: diagnosis and prognosis.
    Expert review of gastroenterology &amp; hepatology· 2026· PMID 41823888mais citado
  6. Development of a Gut Model for Analyzing Impact of Surgical Intervention in Short Bowel Syndrome.
    J Surg Res· 2026· PMID 41990643recente
  7. Glucagon-Like Peptide-1 Receptor Agonists in Managing High Stoma Output: A Scoping Review.
    J Surg Res· 2026· PMID 41990642recente
  8. Delayed Strangulated Right Diaphragmatic Hernia after Retroperitoneal Tumor Resection with Hepatectomy: A Case Report.
    Surg Case Rep· 2026· PMID 41969300recente
  9. Successful initiation of fully parenteral antiretroviral therapy in a treatment-naïve person with HIV-1 infection and intestinal failure.
    HIV Res Clin Pract· 2026· PMID 41964115recente
  10. A Long-Acting Glucagon-like Peptide 2 Protracted by Coomassie Brilliant Blue to Enhance Intestinal Growth in Mice.
    Bioconjug Chem· 2026· PMID 41961990recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:104008(Orphanet)
  2. MONDO:0015183(MONDO)
  3. GARD:1502(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q662272(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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Síndrome do intestino curto
Compêndio · Raras BR

Síndrome do intestino curto

ORPHA:104008 · MONDO:0015183
Prevalência
1-9 / 100 000
CID-10
K91.8 · Outros transtornos do aparelho digestivo, pós-cirúrgicos, não classificados em outra parte
CID-11
Ensaios
27 ativos
Prevalência
2.0 (Europe)
MedGen
UMLS
C0036992
EuropePMC
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