Tumor endócrino gástrico

National Cancer Institute "Cancer Moonshot Biobank"

NCT04314401

RECRUTANDO

Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine Tumors

NCT04090034

RECRUTANDO

Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor

NCT00569127

EM ANDAMENTO

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

NCT02834013

EM ANDAMENTO

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

NCT02465060

EM ANDAMENTO

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT04314401 · National Cancer Institute "Cancer Moonshot Biobank"Recrutando

NCT04090034 · Peptide Receptor Radionuclide Therapy (PRRT) for the Treatme…Recrutando

Outros ensaios clínicos

0 ensaios clínicos encontrados.

Distribuição por fase

NCT00569127 · Octreotide Acetate and Recombinant Interferon Alfa-2b or Bev…Ativo

PHASE3

NCT02834013 · Nivolumab and Ipilimumab in Treating Patients With Rare Tumo…Ativo

PHASE2

NCT02465060 · Targeted Therapy Directed by Genetic Testing in Treating Pat…Ativo

PHASE2

Ver todos no ClinicalTrials.gov

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações

0 papers (10 anos)

#1

First-line zolbetuximab plus mFOLFOX6 and nivolumab in unresectable CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial.

Nature medicine2026 Mar 16

There is an unmet need for effective and safe treatments for patients with metastatic gastric/gastroesophageal junction (mG/GEJ) adenocarcinoma. Targeting claudin 18 isoform 2 (CLDN18.2) and programmed death ligand 1 (PD-L1), represents a promising strategy. Zolbetuximab, a CLDN18.2-targeting antibody, plus chemotherapy improved survival outcomes in patients with CLDN18.2-positive, human epidermal growth factor receptor 2 (HER2)-negative mG/GEJ adenocarcinoma. Cohort 4 of the global, open-label, phase 2 ILUSTRO study examined first-line zolbetuximab plus mFOLFOX6 and nivolumab (a PD-L1 inhibitor). Here we report results from cohorts 4A (safety lead-in phase) and 4B (expansion phase). The primary endpoint of ILUSTRO was specific to cohort 1 and was previously published; the main efficacy endpoint of interest for cohort 4 was progression-free survival (PFS), as assessed by the investigators per Response Evaluation Criteria in Solid Tumors version 1.1. At data cutoff (2 September 2025) for this final analysis, 77 patients were enrolled in 4A + 4B (85.5% with CLDN18.2-high tumors). Cohort 4B median follow-up was 11.5 months, and median PFS (95% confidence interval (CI)) was 14.8 months (8.3-not estimable) overall (n = 71) and 18.0 months (11.1-not estimable) in patients with CLDN18.2-high tumors (n = 59). Objective response rate (measurable disease; 95% CI) was 62.1% (48.4-74.5) in 4B overall (n = 58) and 68.1% (52.9-80.9) in CLDN18.2-high (n = 47). In 4A + 4B, the most common treatment-emergent adverse events were nausea (80.5%) and decreased appetite (72.7%). Efficacy and safety data support randomized evaluation of zolbetuximab plus chemoimmunotherapy in patients with CLDN18.2-positive and PD-L1-positive mG/GEJ adenocarcinoma in the ongoing phase 3 LUCERNA study. ClinicalTrials.gov: NCT03505320 .

#2

Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study.

World journal of gastroenterology2026 Feb 28

Endoscopic treatment is the primary therapy for type I gastric neuroendocrine tumors (G-NETs), but it may not address the underlying pathogenesis, increasing the risk of progression. To investigate the effectiveness of endoscopic treatment and identify progression risk factors. This retrospective study involved 128 patients with type I G-NETs treated between January 2009 and May 2024. The patients were categorized into non-progressive (n = 87) and progressive (n = 41) groups. Baseline characteristics, treatment details, and follow-up data were analyzed using univariate and multivariate Cox regression analyses to identify prognostic variables. The baseline characteristics analysis showed no significant differences between the groups. The median follow-up time was 25.5 months (14.00-58.50 months). The univariate and multivariate analyses confirmed that endoscopic treatment combined with adjuvant somatostatin analogs (SSAs) was associated with a lower risk of progression (hazard ratio = 0.38, 95% confidence interval: 0.17-0.90, P = 0.027), whereas a neutrophil-to-lymphocyte ratio (NLR) of ≥ 2 indicated a higher risk (hazard ratio = 2.14, 95% confidence interval: 1.08-4.26, P = 0.030). Kaplan-Meier analysis confirmed NLR ≥ 2 and adjuvant SSA use as independent prognostic variables. Combining endoscopic treatment with SSAs is effective for managing type I G-NETs. SSAs and NLR were identified as independent prognostic factors, highlighting their potential to reduce recurrence risk and improve outcomes.

#3

[Research progress on liver transplantation therapy for hepatic metastases in gastroenteropancreatic neuroendocrine tumors].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2026 Feb 20

Neuroendocrine tumors are rare, low-grade malignant tumors with a gradually increasing incidence rate in recent years, with gastroenteropancreatic neuroendocrine tumors being the most common among them. The majority of gastropancreatic neuroendocrine tumors have already metastasized to the liver at the time of initial diagnosis; therefore, treatment targeting liver metastases is crucial. The most effective treatment for hepatic metastases of gastropancreatic neuroendocrine tumors is surgical resection. However, 60%-70% of patients are ineligible for radical resection due to diffuse liver involvement. Thus, an alternative treatment option offered for these patients is liver transplantation. Liver transplantation is considered an indication for well-differentiated, unresectable hepatic metastases of gastropancreatic neuroendocrine tumors because of the tumor's low invasiveness, slow growth, and the fact that the liver is often the only distant metastasis site. This article reviews the research progress of liver transplantation therapy for hepatic metastases in gastropancreatic neuroendocrine tumors. 神经内分泌肿瘤是一种低度恶性的罕见肿瘤，近年来发病率在逐渐升高，其中以胃肠胰神经内分泌肿瘤最常见。大多数胃肠胰神经内分泌肿瘤首次确诊时就已经发生了肝转移，因此针对肝转移灶的治疗至关重要。手术切除是胃肠胰神经内分泌肿瘤肝转移最有效的治疗方法，但60%～70%的患者因肝脏弥漫受累而无法接受根治性切除手术，肝移植为此类患者提供了一种可选择的治疗方式。由于该肿瘤侵袭性较低、生长缓慢，且肝脏往往是其唯一的远处转移部位，分化良好的不可切除的胃肠胰神经内分泌肿瘤肝转移被认为是肝移植的适应证。该文对肝移植治疗胃肠胰神经内分泌肿瘤肝转移的研究进展进行综述。.

#4

AGA Clinical Practice Update on Management of Gastric Polyps: Expert Review.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026 Apr

This Clinical Practice Update (CPU) expert review will advise clinicians on the diagnosis and management of gastric mucosal polyps. Gastric polyps are raised epithelial lesions of the gastric mucosa that can arise from various mucosal alterations and perturbations, including mucosal hyperplasia, adenoma, fundic gland proliferation, and enterochromaffin-like cell proliferation. Current guidance on the management of gastric polyps remains limited. This CPU provides a framework for understanding the natural history and epidemiology of gastric polyps and advises on best practices for the endoscopic detection and classification of gastric polyps, the endoscopic resection of gastric polyps, and endoscopic surveillance following resection. Because gastric polyps often occur within a field of altered gastric mucosa (eg, mucosal atrophy, pseudo-pyloric and intestinal metaplasia), we will advise on best practices for the sampling and surveillance of mucosal pathology giving rise to gastric polyps. This CPU is intended to complement other documents issued by the American Gastroenterological Association (AGA) Institute on gastric neoplastic and pre-neoplastic lesions, including the clinical practice guidelines on management of gastric intestinal metaplasia, as well as AGA CPUs on atrophic gastritis, high-quality upper endoscopy, and screening and surveillance of individuals at increased risk for gastric cancer. This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice (BPA) statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these BPA statements do not carry formal ratings regarding the quality of evidence or strength of the presented considerations. BEST PRACTICE ADVICE STATEMENTS BPA 1: Gastric polyps are frequently identified during upper endoscopy exams and include different histologic subtypes, such as fundic gland polyps (FGPs), gastric hyperplastic polyps (GHPs), hamartomatous polyps, gastric adenomas (GAs), pyloric gland adenomas, oxyntic gland adenomas, and gastric neuroendocrine tumors (G-NETs). BPA 2: Clinicians should be aware that different types of gastric polyps may coexist in the same person. BPA 3: Clinicians should be aware that different types of gastric polyps are associated with varying spectra of histopathologic abnormalities in the surrounding gastric mucosa, which may aid in their identification and diagnosis. BPA 4: Systematic endoscopic examination of the polyps and the surrounding gastric mucosa is essential in assessing the underlying gastric mucosa pathology (eg, Helicobacter pylori gastritis, autoimmune gastritis, gastric intestinal metaplasia [GIM]) and determining subsequent management: biopsies of the polyps, biopsies of the surrounding mucosa, and resection of the polyps. BPA 5: All patients with adenomatous or hyperplastic gastric polyps should be tested and treated if positive for H pylori infection. BPA 6: Patients who are using proton pump inhibitors (PPIs) for valid reasons do not need to discontinue these medications in the presence of documented fundic gland hyperplasia-related gastric polyps. BPA 7: Clinicians should be aware that different histological types of gastric polyps have unique/characteristic topographical features, endoscopic features, and size. BPA 8: Endoscopic evaluation of patients with gastric polyps should include complete inspection with high-definition white-light and enhanced imaging, such as virtual chromoendoscopy. Endoscopists should recognize and photo-document the endoscopic features of gastric polyps as well as the surrounding gastric mucosal abnormalities. BPA 9: Clinicians should be aware that endoscopic resection of the polyps includes traditional techniques (snare and biopsy forceps, mucosal resection) or endoscopic submucosal dissection. BPA 10: In the presence of numerous gastric polyps of varied sizes, the largest polyps should be resected when possible, and the smaller polyps sampled or resected. BPA 11: Suspected abnormalities in the surrounding mucosa, such as GIM or atrophic gastritis, should undergo targeted biopsies according to the existing protocols. BPA 12: Surveillance plans in patients with gastric polyps should be formulated based on the histopathological type of the polyps and the surrounding gastric mucosa. BPA 13: When a dysplastic lesion in the polyp is confirmed and resected completely, a follow-up surveillance endoscopy should be completed in 1 year for patients with low-grade dysplasia polyps and 6 months for patients with high-grade dysplasia polyps. If the polyp is biopsied or resection is incomplete, follow-up endoscopy is advised within 3 months for high-grade dysplasia and 6 months for low-grade dysplasia. BPA 14: Endoscopic surveillance is advised in patients with gastric polyps when the histopathology of adjacent mucosa confirms GIM and/or atrophic gastritis.

#5

Diagnostic and Therapeutic Challenges Related to HER2 Heterogeneity in Gastric Cancer: Bridging Molecular Pathology and Clinical Decision-Making.

International journal of molecular sciences2026 Feb 04

HER2 testing represents a cornerstone of the treatment algorithm in advanced gastric and gastroesophageal junction adenocarcinoma (GC), yet its evaluation remains complex due to tumor heterogeneity and methodological variability. Unlike breast cancer, HER2 expression in GC is often incomplete and heterogeneous, resulting in discordant results between biopsies, resections, and metastatic sites. Both spatial and temporal HER2 heterogeneity are key determinants of testing reproducibility, diagnostic accuracy, and treatment selection and response in GC. Optimizing sampling through multiple, well-targeted biopsies, standardizing IHC/ISH protocols, and reassessing HER2 status at progression may be crucial steps to ensure diagnostic accuracy. The recognition of HER2-low disease introduces a new pathological and clinical subgroup of GC with potential sensitivity to antibody-drug conjugates, while emerging techniques such as circulating tumor DNA analysis are increasingly applied to detect HER2 amplification and co-existing genetic alterations. Integrating molecular tools and standardized reassessment strategies can enhance HER2 testing reliability and enable more precise treatment strategies, with the potential to minimize HER2 resistance mechanisms. This review provides a practice-oriented guide on the interpretation and optimization of HER2 testing in gastric cancer, while providing insight into the underlying molecular mechanisms driving heterogeneity and resistance.

Publicações recentes

A rare indolent neuroendocrine tumor of the left intrahepatic bile duct: a case report emphasizing early detection.

Int J Surg Case Rep2026 Apr

Glucagonoma of the pancreas: diagnostic approach and therapeutic algorithm for a rare nosological entity.

Ann Gastroenterol2026 Mar-Apr

Neuroendocrine Tumor of the Cauda Equina: A Report of a Rare Case With Histopathological and Immunohistochemical Correlation.

Cureus2026 Feb

Neuroendocrine Malignancies of the Cervix: What Radiologists Need to Know.

J Comput Assist Tomogr2026 Mar 13

Insulinoma complicated with hypergastrinemia in a subject with type 2 diabetes mellitus: a case report.

Diabetol Int2026 Apr

Ver todas no PubMed

📚 EuropePMC4 artigos no totalmostrando 200

First-line zolbetuximab plus mFOLFOX6 and nivolumab in unresectable CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial.

Nature medicine

Journal of clinical medicine

Clinicopathological Characteristics and Survival Outcomes of Gastrointestinal Neuroendocrine Tumors in a Large Safety Net Hospital.

Prognostic determinants of survival in gastroenteropancreatic neuroendocrine tumors: A real-world evaluation of age, stage, grade, and Ki-67 dynamics.

Surgical oncology

Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study.

Epithelial Neuroendocrine Neoplasms: Grading Based on the New WHO 2022 Guidelines.

Cureus

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Research progress on liver transplantation therapy for hepatic metastases in gastroenteropancreatic neuroendocrine tumors].

Cancer control : journal of the Moffitt Cancer Center

Integrative Molecular Analysis to Predict Clinical Benefit of Everolimus in Patients With Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-NETs).

Correlation between PD-L1 expression and clinical pathology, immunobiological markers, and prognosis in gastroenteropancreatic neuroendocrine neoplasms: a systematic review and meta-analysis.

Frontiers in immunology

A Rare Case of Poorly Differentiated Lower Esophageal Cancer with Neuroendocrine Differentiation and α-Fetoprotein Production.

Surgical case reports

[Merkel-cell carcinoma with gastric metastasis: rare tumor - rare metastasis].

Orvosi hetilap

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

AGA Clinical Practice Update on Management of Gastric Polyps: Expert Review.

International journal of molecular sciences

Diagnostic and Therapeutic Challenges Related to HER2 Heterogeneity in Gastric Cancer: Bridging Molecular Pathology and Clinical Decision-Making.

Annali italiani di chirurgia

Melanoma of Unknown Primary Origin: A Case Report and Literature Review.

Annals of nuclear medicine

Long-term efficacy and safety of peptide receptor radionuclide therapy in Japanese patients with unresectable neuroendocrine tumor: extension of the Japanese phase I and phase I/II study.

Impact of antibiotics on survival outcomes and risk of gastritis/colitis in advanced-stage melanoma patients receiving immune checkpoint inhibitor therapy.

Immunotherapy

Gastroenteropancreatic neuroendocrine neoplasms in children and adults: a comparative review.

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Stomach: A Case Report in a 52-Year-Old Male Following Total D2 Gastrectomy.

Clinical case reports

Pattern of gastrointestinal malignancies in a suburban centre in Southern Nigeria.

African health sciences

Clinico-pathologic characteristics of sub-epithelial tumor (SET) like gastric cancers.

Vitamin D Deficiency and Replacement Challenges in Type 1 Gastric Neuroendocrine Tumors: A Comparative Study.

Nutrients

Research progress on animal models of autoimmune gastritis.

Autoimmunity

Perioperative chemoimmunotherapy for patients with gastric or gastroesophageal junction cancer: a systematic review and meta-analysis.

JNCI cancer spectrum

Pathology oncology research : POR

Digitally derived Ki-67 proliferation index for GastroEnteroPancreatic neuroendocrine neoplasms.

Everolimus as maintenance therapy in advanced neuroendocrine neoplasms: results from the MAVERIC phase II trial.

The oncologist

International journal of cancer

Survival outcomes and prognostic factors of gastric carcinoma with neuroendocrine differentiation.

Cancer control : journal of the Moffitt Cancer Center

Ga-68-Edotreotide PET/CT SSTR Total Tumor Volume as a Predictor of Outcome in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors.

[Clinicopathological characteristics of neuroendocrine cell dysplasia in gastric oxyntic gland mucosa].

Zhonghua yi xue za zhi

Unicentric retrospective study of gastroenteropancreatic neuroendocrine tumors: Updated epidemiological insights.

Cancer epidemiology

Gan to kagaku ryoho. Cancer & chemotherapy

[A Case of Gastric Schwannoma with Tendency to Increase in Size Treated with Laparoscopic Local Gastrectomy].

A deep learning model for the diagnosis of gastric neuroendocrine carcinoma.

Communications medicine

Journal of gastrointestinal cancer

The Vascular Density/Angiogenesis Marker CD31/PECAM1 does not Correlate with Overall Survival in Neuroendocrine Tumors.

Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy.

Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist's roadmap for the clinician.

World journal of gastrointestinal oncology

Advanced gastric small cell carcinoma with immunotherapy-based treatment: A case report.

Canadian journal of gastroenterology & hepatology

Associations Between Gastroenteropancreatic Neuroendocrine Neoplasms and Inflammatory Factors: Insights From a Two-Sample Mendelian Randomization Analysis.

Metabolic signatures in gastroenteropancreatic neuroendocrine neoplasms: unraveling diagnostic and prognostic insights.

Computers in biology and medicine

Subtype classification of gastric spindle cell tumors in whole slide images.

The American journal of case reports

Diagnostic Challenges of Abdominal Tumors Without Typical Imaging Features: From Misdiagnosis of Pancreatic Cystadenoma to Adrenal Pheochromocytoma and the Intraoperative Response.

Seminars in cancer biology

Obesity and GEP-NEN: what's new?

Dosimetry-guided peptide receptor radionuclide therapy in neuroendocrine tumors: interim safety analysis of the DUONEN trial.

Incidence of Gastric Cancer and Neuroendocrine Tumors in Autoimmune Gastritis: A Systematic Review and Meta-Analysis of Follow-Up Studies.

Helicobacter

Gastric neuroendocrine tumors associated with acid suppressant drugs are frequently associated with very prolonged drug use and may show unconventional morphologies.

Human pathology

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

Assessment of the clinical and morphological characteristics of visceral melanoma metastases and primary extracutaneous melanomas.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Targeted β--Particle Plus Conversion and Auger-Electron Therapy with 161Tb-Labeled Somatostatin Receptor Antagonist DOTA-LM3: A Phase 0 Study.

Critical reviews in oncology/hematology

High-grade gastro-entero-pancreatic neuroendocrine neoplasms: An overlooked population in interventional clinical trials. A systematic review.

Journal of visualized experiments : JoVE

Diagnosis and Management of Duodenal Bulb Neuroendocrine Carcinoma with Liver Metastases: A Case Report and Literature Review.

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature.

European journal of radiology

Safety and efficacy of Yttrium-90 transarterial radioembolization of neuroendocrine liver metastasis - A retrospective single-institution study.

Medicina (Kaunas, Lithuania)

Are HDAC and Glutamine Synthetase Expression Levels Associated with Ga68-DOTATATE PET/CT Data and Prognosis in Gastroenteropancreatic Neuroendocrine Tumours?

Annals of diagnostic pathology

Clinicopathological characterization of gastric amphicrine carcinoma: A case series.

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[A real-world study of 15,644 patients undergoing D2 radical gastrectomy over 11 years at Shanxi provincial cancer hospital].

Virchows Archiv : an international journal of pathology

Differentiating well-differentiated neuroendocrine tumors grade 3 from poorly differentiated neuroendocrine carcinomas and adenocarcinoma with neuroendocrine differentiation: a comprehensive review.

Virchows Archiv : an international journal of pathology

Neuroendocrine neoplasms of the stomach. Update on diagnostic criteria, classification, and prognostic markers.

Delta-Like Ligand 3 Expression and Functional Imaging in Gastroenteropancreatic Neuroendocrine Neoplasms.

JCO precision oncology

Risk assessment of type I gastric neuroendocrine tumors based on endoscopic and clinical features of autoimmune gastritis.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

A Case of Grade 3 Gastric Neuroendocrine Tumor with Glandular Formation: Diagnostic Process and Differentiation from Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm.

Gastroenteropancreatic Neuroendocrine Tumors.

Gastroenterology

Predictors of survival outcomes in patients with neuroendocrine neoplasms: a real-world retrospective study.

Endocrine-related cancer

American journal of surgery

Impact of non-metropolitan residence on survival for gastric neuroendocrine tumors.

Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

ESMO open

Attribute Preferences for Somatostatin Analogues in Neuroendocrine Tumours (NETs) Among Patients, Clinicians and Nurses in Australia.

Cancer medicine

Systematic review and meta-analysis of the efficacy and safety of [177Lu]Lu-edotreotide ([177Lu]Lu-DOTATOC) for the treatment of neuroendocrine tumors.

Successful surgical removal of a retroperitoneal paraganglioma in the celiac artery trifurcation in a dog.

BMC veterinary research

Linked color imaging for detection and characterization of gastrointestinal neuroendocrine tumors.

BMC gastroenterology

Journal of gastrointestinal cancer

The Association Between Proton Pump Inhibitor Use and Gastroenteropancreatic Neuroendocrine Tumors: A Systematic Review.

Clinics and research in hepatology and gastroenterology

Do serum biomarkers correlate to the risk of gastric lesions in patients with autoimmune gastritis༟-A systematic review and meta-analysis.

Revista de gastroenterologia de Mexico (English)

Gastroenteropancreatic neuroendocrine neoplasms: Clinical-pathologic analysis of 48 cases treated at the Hospital Ángeles del Pedregal in Mexico City between 2018 and 2024.

PReCedeNT trial: Phase III randomized-controlled trial of Lutetium - 177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) plus Chemotherapy versus PRRT alone in FDG-avid, Well-differentiated Gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[Clinicopathological characteristics and prognostic factors in 36 cases of early-stage gastric mixed adenoneuroendocrine carcinoma].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

[Neuroendocrine carcinoma with significantly vacuolar nucleus at the esophagogastric junction: A case report].

Nuclear medicine communications

Progression of intracardiac metastases from gastroenteropancreatic neuroendocrine tumors.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Exploring the potential of artificial intelligence in assessing the risk of gastric neoplastic lesions in patients with corpus atrophic gastritis.

International journal of biological macromolecules

Oral delivery of PARP inhibitor via gelatin- and chitosan-based nanocarriers for refined therapy of primary and metastatic melanomas.

Annals of oncology : official journal of the European Society for Medical Oncology

177Lu-Dotatate versus high-dose long-acting octreotide for the treatment of patients with advanced, grade 1-2, well-differentiated gastroenteropancreatic neuroendocrine tumours (XT-XTR008-3-01): an open-label, randomised, phase III trial.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Incidence and risk of gastric neuroendocrine tumors and adenocarcinoma in patients with atrophic gastritis/pernicious anemia.

Insights into gastric mixed adenoneuroendocrine carcinoma: a novel comparative study of clinicopathological features and survival outcomes.

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

Lancet (London, England)

International journal of surgery (London, England)

Gastric neuroendocrine neoplasms: updated epidemiology and externally validated prognostic nomogram.

Postoperative gastric cancer accompanied by large-cell neuroendocrine carcinoma: A case report.

Medicine

Rare primary malignant melanoma of the esophagus with gastric cardia adenocarcinoma: A case report.

Medicine

Prognostic factors and survival in gastroenteropancreatic neuroendocrine neoplasm: Real-world evidence from a South American Single-Center Cohort.

Annales d'endocrinologie

The Role of Radioligand Therapy in Gastroenteropancreatic Neuroendocrine Tumors: An Italian Expert Opinion.

Advances in therapy

Thermostable enzyme isoforms, continuously producing monocomponent superoxide radicals, from human postoperative serous fluids: isolation and properties.

Evaluating the role of postoperative long-acting somatostatin analog therapy in patients with metastatic neuroendocrine tumors undergoing surgical debulking.

Surgery

Immune Checkpoint Inhibitors in High-grade Gastroenteropancreatic Neuroendocrine Neoplasms.

Endocrine reviews

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Outcomes of device assisted endoscopic full thickness resection in gastroduodenal submucosal lesions: A large, multicentre study (with videos).

The journal of pathology. Clinical research

Histopathology-based assessment of the tumour microenvironment in gastrointestinal cancers: practical approaches to prognostication and treatment stratification.

Current treatment options in oncology

Update in the Management of ACTH-Secreting Gastroenteropancreatic and Thoracic Neuroendocrine Neoplasms.

Clinical and Histopathological Correlations With Blood Groups in Patients With Gastric Cancer.

Cureus

Annals of surgical oncology

Association Between Long-Term Proton Pump Inhibitor Use and Low-Risk Gastric Neuroendocrine Tumors.

World journal of clinical oncology

Gastric neuroendocrine tumors: A review of pathology and updated roadmap to surgical management.

Journal of the Endocrine Society

MEN1-Related Neuroendocrine Tumors Show c-MET Overexpression.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

The indolent nature of type 1 gastric neuroendocrine tumors under 1 cm.

Gastrointestinal Neuroendocrine Neoplasms in Children and Adolescents: Data from the German MET Studies (1997-2024).

JGH open : an open access journal of gastroenterology and hepatology

Differences in Endoscopic Features of Gastric Neuroendocrine Tumor and Neuroendocrine Carcinoma From a Clinicopathological Perspective.

Aurora kinase A inhibition as a synthetic lethality strategy in ARID1A-mutated gastroenteropancreatic neuroendocrine carcinoma.

Cancer letters

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Gastric neuroendocrine tumors arising from chronic proton pump inhibitor use: characteristics and outcomes of a fourth subtype.

Management of type I gastric-neuroendocrine tumors: the less the better?

Clinical drug investigation

Radioligand Therapies (RLTs) and Healthcare System Readiness: From the Experience in GEP-NET, a Retrospective Analysis on DRG and Mobility to Improve the Accessibility to the Future RLT in Italy.

Journal of gastroenterology

Development of gastric mucosa-associated microbiota in autoimmune gastritis with neuroendocrine tumors.

Underwater traction-assisted endoscopic submucosal dissection of a neuroendocrine tumor in the duodenal bulb.

Endoscopy

Annals of diagnostic pathology

Diagnostic value of SSTR2A, ATRX, and clusterin immunohistochemical expression in high-grade gastroenteropancreatic neuroendocrine neoplasms.

World journal of psychiatry

Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study.

68Ga-DOTATATE PET/CT versus MRI in neuroendocrine liver metastases: a comprehensive per-lesion analysis.

La Radiologia medica

Revista de gastroenterologia de Mexico (English)

Gastroenteropancreatic neuroendocrine tumors: A retrospective study conducted in the Colombian Southwest.

Circulating Tumor DNA Profiling Identifies Actionable Mutations as Prognostic Markers in Advanced Neuroendocrine Tumors.

Patient-Derived Organoids from Multiple Sites of a Single Tumor Recapitulates Intratumoral Heterogeneity in Patients with Gastric Cancer.

Gut and liver

Orphanet journal of rare diseases

Complications and recurrence risks after endoscopic resection of digestive neuroendocrine tumors: a retrospective study.

Real-World Patient Outcomes on the Efficacy of Lanreotide Treatment for Neuroendocrine Tumors: The Influence of Body Mass Index, Body Surface Area, and Renal Function.

Assessment of Remnant Gastric Perfusion Using Indocyanine Green During Pancreaticoduodenectomy After Gastrectomy: A Case Report.

Anticancer research

Artificial intelligence in the diagnosis of gastro-entero-pancreatic neuroendocrine neoplasms: Potential benefits and current limitations.

The Causal Role of Gut Microbiota and Immune Cell Mediation in Gastroenteropancreatic Neuroendocrine Neoplasms: A Mendelian Randomization Study.

Anti-tumor potential of combinatory GSK3 inhibition in human 3D models of pancreatic neuroendocrine tumors and patient-derived GEP-NET primary cultures.

Endocrine-related cancer

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.

Nature

Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study-TCOG T1214 study.

Cancer

International journal of molecular sciences

Identification of miRNA/FGFR2 Axis in Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors.

The Impact of DDR Gene Mutations on the Efficacy of Etoposide Plus Cisplatin in Grade 3 Metastatic Gastroenteropancreatic (GEP)-Neuroendocrine Carcinoma (NEC).

Cancers

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

[Case report: uveal melanoma with gastric metastases].

Controversies in NEN: An ENETS position statement on the treatment of patients with Grade 3 well-differentiated neuroendocrine tumours of the gastro-enteropancreatic tract.

Management of liver metastases from non-functional gastroenteropancreatic neuroendocrine tumors: a systematic review.

Evaluation of therapeutic agent selection based on comprehensive genomic profiling in gastroenteropancreatic neuroendocrine neoplasms.

PloS one

European journal of nuclear medicine and molecular imaging

Predicting 177Lu-DOTATATE therapy response through immune microenvironment parameters in gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

Journal of surgical case reports

Large metastatic lymph nodes misdiagnosed as a pancreatic tumor: a case report.

Virchows Archiv : an international journal of pathology

Dual-expression (primitive enterocyte phenotype and neuroendocrine differentiation) gastric adenocarcinoma: the unique high-aggressive subtype.

World journal of clinical oncology

Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis.

International journal of cancer

Ramucirumab-containing chemotherapy for patients with gastrointestinal neuroendocrine carcinoma refractory/intolerant to platinum-based chemotherapy: A multicenter observational retrospective study (WJOG13420G).

2024

Case Report: Overlooked Skin Melanoma Unveiled by Gastric Metastasis.

F1000Research

Nutritional Management of Functioning GEP-NENs.

Nutrients

Diagnosis model for gastric submucosal tumor based on multiple decision trees comprising endoscopic and endoscopic ultrasonography features.

BMC gastroenterology

The clinical benefits of [18F]AlF-NOTA-octreotide PET/CT in staging and restaging patients with gastroenteropancreatic neuroendocrine neoplasms: comparison of [18F]FDG PET/CT.

BMC medical imaging

Histopathological features of gastrointestinal and pancreatic neuroendocrine neoplasms: An 11-year retrospective study from a tertiary center in Saudi Arabia.

Saudi medical journal

Endoscopic submucosal dissection for gastric neuroendocrine neoplasms: A multicenter retrospective study.

Somatostatin analogue continuation upon progression in patients with gastroenteropancreatic neuroendocrine tumour (SAUNA trial): a randomised controlled trial protocol.

BMJ open

Case reports in gastroenterology

Zollinger-Ellison Syndrome Unmasked during Hiatal Hernia Evaluation: A Case Report.

[Clinical and endoscopic features of autoimmune gastritis with gastric neoplastic lesions].

Zhonghua nei ke za zhi

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Efficacy of nodal dissection for locoregional gastric neuroendocrine carcinoma: a multicenter retrospective observational study.

Australian veterinary journal

Gastric gastrinoma in a dog: a case report, application of current WHO criteria for prognostication and validation of a local gastrin immunohistochemistry assay.

Annals of nuclear medicine

Comparison of radiolabeled somatostatin analogs (DOTATATE, DOTANOC, and DOTATOC) in somatostatin receptor (SSTR) imaging for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a narrative literature review.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[68Ga-DOTATATE and 18F-FDG PET/CT dual-modality imaging enhances precision of staging and treatment decision for gastroenteropancreatic neuroendocrine neoplasms].

Internal medicine (Tokyo, Japan)

Ectopic Insulinoma in the Pyloric Antrum Portion of the Stomach: A Case Report and Review of the Associated Diagnostic Challenges.

Phase II study of avelumab and trastuzumab with FOLFOX chemotherapy in previously untreated HER2-amplified metastatic gastroesophageal adenocarcinoma.

The oncologist

International journal of molecular sciences

The Role of the Tumor Microenvironment in Gastroenteropancreatic Neuroendocrine Tumors.

Controversies in NEN: An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms.

Association of integrated biomarkers and progression-free survival prediction in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy.

Theranostics

Archives of pathology & laboratory medicine

Histopathologic Progression of Autoimmune Atrophic Gastritis: A Retrospective Review of 180 Specimens From 32 Patients.

World journal of clinical oncology

Last decade of advances in gastric neuroendocrine tumors: Innovations, challenges, and future directions.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Cost-Effectiveness of [177Lu]Lu-DOTATATE for the Treatment of Newly Diagnosed Advanced Gastroenteropancreatic Neuroendocrine Tumors: An Analysis Based on Results of the NETTER-2 Trial.

European journal of gastroenterology & hepatology

Autoimmune chronic atrophic gastritis: association between chronic proton pump inhibitors use and more severe atrophy and gastric intestinal metaplasia.

European journal of cancer (Oxford, England : 1990)

Navigating the clinical challenges of zolbetuximab in patients with claudin positive advanced gastric cancer.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Risk factors associated with adenocarcinoma development in gastric neuroendocrine tumors: A multicenter 10-year follow-up study.

Fragility fractures in well-differentiated gastroenteropancreatic neuroendocrine tumors: Results from a multicentered retrospective study.

Predictive factors for persistent thrombocytopenia after peptide receptor radioligand therapy in enteropancreatic neuroendocrine tumors.

Diseases (Basel, Switzerland)

Clinical Heterogeneity of Early-Onset Autoimmune Gastritis: From the Evidence to a Pediatric Tailored Algorithm.

Scandinavian journal of gastroenterology

The central role of gastrin in Helicobacter pylori gastric carcinogenesis.

Synchronous neuroendocrine tumor and signet ring cell carcinoma in the stomach: a case report and review of literature.

Frontiers in medicine

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

[18F]FDG Metabolic Tumor Volume as a Prognostic Marker in Neuroendocrine Neoplasm: A Multicenter Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Risk Factors Associated with Gastroenteropancreatic and Lung Neuroendocrine Tumors: A Nested Case-Control Study from the All of Us Research Program.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases.

Impact of multikinase inhibitors in reshaping the treatment of advanced gastroenteropancreatic neuroendocrine tumors.

Endocrine-related cancer

Multiple Gastric Schwannoma: A Case Report.

Current medical imaging

Clinical and experimental medicine

The persistent risk of secondary malignancies in gastric neuroendocrine tumor survivors: a population-based analysis.

Expression of insulinoma-associated protein 1 (INSM1) in gastric neuroendocrine and non-neuroendocrine neoplasms.

Discover oncology

International journal of surgical pathology

Gastrointestinal Amphicrine Carcinoma: A Clinicopathologic Study of Five Patients.

A single center retrospective analysis of feasibility of diagnostic endoscopic resection for grade 1 or 2 gastric neuroendocrine tumors.

Diagnostic accuracy and influencing factors of microprobe endoscopic ultrasound for gastrointestinal subepithelial lesions: a multicenter retrospective study.

BMC gastroenterology

Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline.

JCO oncology practice

European journal of cancer (Oxford, England : 1990)

Proof of concept and design of an externally controlled trial for patients with gastro-enteropancreatic neuroendocrine carcinomas based on the randomized phase II BEVANEC trial.

Gastric Neuroendocrine Tumor With Pancreatic Acinar Cell Differentiation in the Background of Atrophic Gastritis: A Possible Variant of Type 1 ECL-Cell NET-A Case Report.

Pathology international

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Can Lymph Node Metastasis be Predicted in Gastroenteropancreatic Neuroendocrine Neoplasias?

Clinical journal of gastroenterology

Long-term survival with complete remission after irinotecan plus cisplatin therapy for metachronous liver metastasis from a gastric mixed neuroendocrine-non-neuroendocrine neoplasm: a case report.

Clinical nuclear medicine

Post-marketing Safety Evaluation of Lutathera ( 177 Lu-DOTATATE) : A Pharmacovigilance Analysis of FDA Adverse Event Reporting System.

Clinical nuclear medicine

18 F-FDG Versus 68 Ga-FAPI PET/MRI Findings in a Case of Primary Gastric Melanoma.

Revista medica del Instituto Mexicano del Seguro Social

[Laparoscopic management of gastric schwannoma].

Revista espanola de enfermedades digestivas

Endoscopic misdiagnosis of a polypoid gastric neuroendocrine neoplasm: literature review.

Revista espanola de enfermedades digestivas

Prevalence and evolution of newly diagnosed autoimmune gastritis in a large Spanish retrospective cohort.

Gastric SMARCA4-deficient undifferentiated tumors: clinicopathological analysis of two cases in a single center.

Diagnostic pathology

A systematic review on endoscopic ultrasound in gastric neuroendocrine neoplasms: guidelines outpacing evidence.

Clinical endoscopy

Case Report: Gastric submucosal neoplasm with CTNNB1 mutation showing GLI1 overexpression and epithelial differentiation.

Frontiers in medicine

Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Optimal Approaches to Grading Enteropancreatic Neuroendocrine Tumors Using Ki-67 Proliferation Index: Hotspot and Whole-Slide Digital Quantitative Analysis.

Translational cancer research

Survival analysis of gastric malignancy patients: identifying key prognostic factors.

Journal of gastroenterology

Clinical application of targeted α-emitter therapy in gastroenteropancreatic neuroendocrine neoplasms.

Prognostic value of neutrophil-lymphocyte ratio in gastroenteropancreatic neuroendocrine neoplasm: a systematic review and meta-analysis.

PeerJ

A Prospective Study on the Detection of Gastric Neoplasms Using Pepsinogen and Gastrin-17 Levels.

Gut and liver

Regorafenib plus avelumab in advanced gastroenteropancreatic neuroendocrine neoplasms: a phase 2 trial and correlative analysis.

Nature cancer

Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.

Cancer medicine

Adjuvant TRastuzumab deruxtecan plus fluoropyrimidine versus standard chemotherapy in HER2-positive gastric or gastroesophageal cancer patients with persistence of minimal residual disease in liquid biopsy after pre-operative chemotherapy and radical surgery: the multicentre, phase II randomized TRINITY trial.

European journal of nuclear medicine and molecular imaging

Safety and dosimetry of [177Lu]Lu-DOTA-TATE in adolescent patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumours, or pheochromocytomas and paragangliomas: Primary analysis of the Phase II NETTER-P study.

Clinical and translational gastroenterology

Expression Patterns of Immune Checkpoint Molecules and Their Clinical Values in Gastric Neuroendocrine Neoplasms.

Clinicopathologic characteristics and prognostic factors of pure gastric neuroendocrine carcinoma patients undergoing radical surgery.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

Type 2 and type 3 gastric neuroendocrine tumors have high risk of lymph node metastasis: Systematic review and meta-analysis.

European journal of nuclear medicine and molecular imaging

Beyond similarities: overall survival and prognostic insights from [¹⁷⁷Lu]Lu-DOTATOC therapy in neuroendocrine tumors.

Gastrointestinal involvement in metastatic melanoma.

BMJ case reports

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

PET- and CT-Based Imaging Criteria for Response Assessment of Gastroenteropancreatic Neuroendocrine Tumors Under Radiopharmaceutical Therapy.

European journal of nuclear medicine and molecular imaging

Safety and efficacy of re-treatment with [177Lu]Lu-DOTA-Octreotate radionuclide therapy in progressive gastro-entero-pancreatic neuroendocrine tumours - a single centre experience.

Annals of surgical oncology

Survival and Metastatic Lymph Node Patterns in Gastric Carcinoma with Exocrine and Neuroendocrine Components.

Development and validation of predictive models for distant metastasis and prognosis of gastroenteropancreatic neuroendocrine neoplasms.

Annals of nuclear medicine

Physiological bio-distribution of 68Ga-DOTA-TATE in pediatric patients.

Clinical characteristics and treatment patterns of patients with gastroenteropancreatic neuroendocrine neoplasia in Germany receiving peptide receptor radionuclide therapy: A real-world data registry-based study.

Medicine

Virchows Archiv : an international journal of pathology

An emerging entity of gastric adenocarcinoma: clinicopathological features and differential diagnosis of gastric adenocarcinoma of fundic-gland type in 25 retrospective cases.

Próxima:Associações

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Tumor endócrino gástrico.

É de uma associação que acompanha esta doença? Fale com a gente →

Próxima:Comunidades

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Tumor endócrino gástrico

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Próxima:Tire suas dúvidas

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Próxima:Doenças relacionadas

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

Tumor endócrino enteropancreático

32 em comum

ORPHA:100092

Tumor endócrino do cólon

23 em comum

ORPHA:100080

NÃO RARA NA EUROPA: Câncer colorretal

21 em comum

ORPHA:466667

Tumor endócrino anal

ORPHA:100082

Carcinoma do canal anal

ORPHA:424013

Tumor endócrino retal

Tumor epitelial do canal anal

ORPHA:100081