Telotristat etil, etiltelotristato,, telotristato de etila ou telotristat ethyl é um pró-fármaco de telotristat, o qual é um inibitor de triptofano hidroxilase. É formulado como etiprato de telotristat — um sal hipurato do telotristat etil.
Introdução
O que você precisa saber de cara
Tumor carcinoide e síndrome carcinoide são condições associadas a tumores neuroendócrinos, frequentemente pulmonares, que produzem excesso de serotonina. Isso pode levar a sintomas como diarreia, rubor, sopros cardíacos e rinorreia, com mutações no gene SDHD sendo um fator de risco.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 9 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 27 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10482792, PubMed:9533030). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate
Mitochondrion inner membrane
Pheochromocytoma/paraganglioma syndrome 1
A form of pheochromocytoma/paraganglioma syndrome, a tumor predisposition syndrome characterized by the development of neuroendocrine tumors, usually in adulthood. Pheochromocytomas are catecholamine-producing tumors that arise from chromaffin cells in the adrenal medulla. Paragangliomas develop from sympathetic paraganglia in the thorax, abdomen, and pelvis, as well as from parasympathetic paraganglia in the head and neck. PPGL1 inheritance is autosomal dominant.
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
267 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
3 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Tumor carcinoide e síndrome carcinoide
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
39 ensaios clínicos encontrados, 5 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 733
Oxalate nephropathy from untreated pancreatic insufficiency in a neuroendocrine tumour patient.
Pancreatic exocrine insufficiency (PEI) is an under-recognised cause of chronic diarrhoea in patients with neuroendocrine tumours (NETs). If left untreated or undertreated, PEI can lead to complications such as oxalate nephropathy (ON), which may result in loss of kidney function and potentially limit oncologic treatment options, including peptide receptor radionuclide therapy (PRRT). We present a man in his late 60s with a small bowel NET who developed persistent, uncontrolled diarrhoea for several years. The diarrhoea was attributed to multiple factors, including secretory NET (ie, carcinoid syndrome), bile acid diarrhoea and PEI secondary to somatostatin analogue therapy. Due to financial constraints, the patient was unable to consistently take pancreatic enzyme replacement therapy (PERT). Years after the diagnosis of NET, the patient developed a new onset worsening of kidney function. Further work-up, including a kidney biopsy, confirmed ON, which significantly limited subsequent treatment options, including PRRT. Routine screening for PEI and early initiation of PERT should be considered in all NET patients with chronic diarrhoea to prevent ON and preserve future treatment options.
Real-World Observational Study of Somatostatin Analogs and Rescue Medication Usage for Neuroendocrine Tumors in Canada.
Neuroendocrine tumors (NETs) are uncommon malignancies with increasing incidence in Canada. Long-acting somatostatin analogs (SSAs) such as Lanreotide Autogel (LAN-ATG) and Octreotide Long-Acting Release (OCT-LAR) are first-line treatments for well-differentiated GEP-NETs either with or without carcinoid syndrome (CS). Despite their efficacy, many patients require short-acting SSAs for breakthrough symptoms. We investigated the impact of switching between long-acting SSAs on the usage of breakthrough medications and the incidence of above maximum recommended dose (AMRD) prescriptions. This population-based study used claims data from the IQVIA Canadian Private Drug Plan (PDP) that includes data from all Canadian provinces and public drug programs from Ontario and Québec. We identified NET patients who switched SSAs between September 2015 and December 2021. We analyzed breakthrough medication usage and AMRD prescriptions before and after the switch. Among 170 patients who switched SSAs, there was a 59.1% overall reduction in breakthrough medication claims post-switch. Patients switching from OCT-LAR to LAN-ATG experienced a 66.5% reduction, while those switching from LAN-ATG to OCT-LAR saw a 21.9% decrease. Pre-switch, significantly more patients on OCT-LAR exceeded the AMRD threshold compared to those on LAN-ATG (43.8% vs. 18.2%, p value = 0.008). Switching between long-acting SSAs can reduce the need for breakthrough medications and lower the incidence of AMRD prescriptions, with a more pronounced effect observed when switching from OCT-LAR to LAN-ATG. These findings have potential implications for improving quality of life and reducing treatment costs for NET patients, which should be evaluated in a formal health economic analysis.
Recurrent ventricular asystole during octreotide infusion in a patient with pancreatic neuroendocrine tumor: a case report.
Somatostatin analogs such as octreotide are frequently used in the prevention of carcinoid syndrome in the perioperative period following neuroendocrine tumor resection. This is the first reported case of ventricular asystole associated with postoperative intravenous octreotide infusion in a patient with previous congenital cardiac surgery. We present the case of a 62-year-old white British male patient with a history of previous congenital cardiac surgery who sustained multiple episodes of ventricular asystole and associated loss of cardiac output during octreotide infusion. Recurrent asystole ceased following discontinuation of the octreotide infusion. Physicians caring for patients receiving intravenous octreotide should be aware of the potential arrhythmogenic adverse effects. While specific risk factors for octreotide-associated arrhythmias are not generally understood, previous cardiac surgery could potentially be one of these. Risk stratification guidance regarding patient groups requiring heightened monitoring while receiving intravenous octreotide is required. Monitoring recommendations may involve invasive blood pressure monitoring and telemetry in these cases.
Determining Prognosis in Patients With Carcinoid Syndrome: A Retrospective Single-Center Cohort Study.
Carcinoid syndrome (CS), the most prevalent neuroendocrine tumor (NET)-related hormonal syndrome, is associated with impaired survival. However, the contribution of NET-specific death in patients with this syndrome is currently unknown. This study aimed to evaluate overall survival (OS), prognostic factors, and causes of death in patients with CS. We retrospectively included patients with CS treated between 1995 and 2021 at our ENETS Center of Excellence. We used Kaplan-Meier curves and log-rank tests to perform survival analyses, and a Cox proportional hazards model to calculate mortality hazard ratios (HRs). A total of 295 of 427 included patients with CS died during follow-up, and cause of death was recorded in 255 patients. In 231 (90.6%) patients, the cause of death was NET-specific. Median OS was 7.1 years, and 65.1% and 34.1% of CS patients were alive at 5 and 10 years, respectively. Multivariate analysis identified age (HR, 1.06; P<.001), WHO tumor grade 2 (HR, 2.11; P=.01), plasma chromogranin A (CgA) level of 200 to 940 µg/L (HR, 1.64; P=.04), CgA level >940 µg/L (HR, 3.18; P<.001), and primary lung NET (HR, 1.77; P=.008) as negative predictors of survival. The presence of carcinoid heart disease (HR, 1.01; P=.97) was not associated with OS in a multivariate model due to interaction with CgA levels. Patients with CS are likely to succumb to their disease, with >90% of mortality being NET-specific. Age, tumor grade, primary lung origin, and CgA levels were independent predictors of mortality. These findings indicate that there is an urgent need for advances in therapeutic options for patients with CS.
Multivalvular Cardiac Involvement from Giant Hepatic Metastases of an Ileal Neuroendocrine Tumor.
Intestinal neuroendocrine tumors (NETs) are rare, slow-growing neoplasms arising from enterochromaffin cells, capable of secreting vasoactive substances that may cause carcinoid syndrome (CS) and clinically significant valvular heart disease. These tumors are often diagnosed at advanced stages due to nonspecific gastrointestinal symptoms, and distant metastases, particularly to the liver and lymph nodes, are common at presentation. Hormonal dysregulation can lead to chronic diarrhea, flushing, and bronchospasm, while carcinoid heart disease (CHD) contributes substantially to morbidity and mortality, typically affecting right-sided valves, with left-sided involvement being uncommon and more frequently associated with intracardiac shunts than exceptionally high serotonin exposure. Recent advances in management emphasize a multidisciplinary approach integrating systemic therapy, surgery, and targeted radionuclide treatment. Somatostatin analog therapy remains the cornerstone for controlling hormonal symptoms and slowing tumor progression. Aggressive cytoreductive surgery to achieve hormonal stabilization prior to surgical valve replacement has been associated with improved survival, symptomatic relief, and cardiac function. Targeted peptide receptor radionuclide therapy provides additional treatment for residual or metastatic disease, enhancing biochemical and radiological control. We report the case of a 61-year-old woman with chronic diarrhea, weight loss, and recurrent flushing, diagnosed with a well-differentiated ileal NET with extensive hepatic metastases and severe right-sided valvular disease with mild left-sided involvement. She underwent somatostatin analog therapy to control hormonal symptoms, cytoreductive surgery, and surgical replacement of the pulmonary and tricuspid valves. Subsequent targeted peptide receptor radionuclide therapy further reduced tumor burden and stabilized biochemical markers. This combined multimodal strategy resulted in sustained clinical improvement, normalization of neuroendocrine markers, and long-term oncologic stability, as the patient remains asymptomatic and oncologically stable after four years of follow-up from initial presentation. This case highlights the importance of early recognition, comprehensive evaluation, and a multidisciplinary strategy in advanced NETs. Coordinated care integrating endocrinology, oncology, cardiology, nuclear medicine, and surgery can significantly improve survival, hormonal control, and quality of life in patients with complex metastatic disease.
Publicações recentes
Neuroendocrine Tumors and Pregnancy: The French PregNET Study.
Impact of Symptom Phenotype on Surgical Quality and Survival in Small-Bowel Neuroendocrine Tumours: A Quality Metrics Analysis.
Real-World Observational Study of Somatostatin Analogs and Rescue Medication Usage for Neuroendocrine Tumors in Canada.
Recurrent ventricular asystole during octreotide infusion in a patient with pancreatic neuroendocrine tumor: a case report.
Determining Prognosis in Patients With Carcinoid Syndrome: A Retrospective Single-Center Cohort Study.
📚 EuropePMC1.041 artigos no totalmostrando 194
Real-World Observational Study of Somatostatin Analogs and Rescue Medication Usage for Neuroendocrine Tumors in Canada.
NeuroendocrinologyRecurrent ventricular asystole during octreotide infusion in a patient with pancreatic neuroendocrine tumor: a case report.
Journal of medical case reportsDetermining Prognosis in Patients With Carcinoid Syndrome: A Retrospective Single-Center Cohort Study.
Journal of the National Comprehensive Cancer Network : JNCCNMultivalvular Cardiac Involvement from Giant Hepatic Metastases of an Ileal Neuroendocrine Tumor.
CureusPersistent facial flushing as a cutaneous manifestation of carcinoid syndrome.
Medicina clinicaOxalate nephropathy from untreated pancreatic insufficiency in a neuroendocrine tumour patient.
BMJ case reportsOncological Outcomes after Elective and Emergency Resection of Small Intestinal Neuroendocrine Tumours.
Journal of gastrointestinal cancerNonmetastatic Pulmonary Carcinoid Presenting With Carcinoid Syndrome Despite Negative 5-HIAA: A Case Report.
Case reports in endocrinologyCarcinoid Heart Disease: Diagnostic Value of Cardiac MRI in a Patient With Metastatic Small‑Intestinal Neuroendocrine Tumor.
Journal of the Belgian Society of RadiologyContrast-Enhanced Ultrasound and Somatostatin Receptor Scintigraphy Unveil an Occult Neuroendocrine Tumor With Carcinoid Syndrome and Presumed Small Intestinal Origin - A Case Report.
Gastro hep advancesLUNG CARCINOIDS (Lung Neuroendocrine Tumors).
Endocrine reviewsIntravenous adrenaline (epinephrine): its use in the critical care setting.
Postgraduate medical journalDiagnosis and Treatment of Right-Sided Valve Disease in Cardiac Carcinoid Syndrome: A Systematic Review.
CardiologyOvarian carcinoid tumor with carcinoid heart syndrome: A case report and literature review.
Gynecologic oncology reportsExploring the carcinoid crisis: insights from a cancer-specific centre.
Endocrine oncology (Bristol, England)Flushing in Carcinoid Syndrome.
Actas dermo-sifiliograficasParaneoplastic Neurological Syndromes in Oncology: Clinical Features, Mechanisms, and Educational Perspectives.
Journal of cancer education : the official journal of the American Association for Cancer EducationMetastatic neuroendocrine neoplasms of the breast: a systematic review.
Endocrine-related cancerASO Visual Abstract: Carcinoid Syndrome Impacts Long-Term Outcomes After Hepatectomy for Small Bowel Neuroendocrine Tumor Liver Metastasis.
Annals of surgical oncologyCarcinoid Heart Disease Revealing the Burden of a Neuroendocrine Tumour: A Case Report.
CureusUncommon Origin, Common Presentation: A Rare Case of Mesenteric Carcinoid Tumor Mimicking Functional Gastrointestinal Disorders.
CureusPaltusotine versus octreotide: different effects on radioligand uptake in neuroendocrine tumours.
Endocrine oncology (Bristol, England)Complications of ovarian metastases from well-differentiated small bowel neuroendocrine neoplasms: a focus on bowel and ureteral obstruction.
Surgical oncologyAIMN, ITANET, SIE joint position paper for the recognition, prevention and management of NET carcinoid syndrome and crises during peptide receptor radionuclide therapy.
European journal of nuclear medicine and molecular imagingCarcinoid Syndrome Impacts Long-Term Outcomes After Hepatectomy for Small Bowel Neuroendocrine Tumor Liver Metastasis.
Annals of surgical oncologyBilateral carcinoid heart disease secondary to a massive right-to-left shunt through a patent foramen ovale: a case report.
European heart journal. Case reportsTelotristat ethyl affects tumour-fibroblast crosstalk in small intestinal neuroendocrine tumours.
Journal of neuroendocrinologyCase report of carcinoid syndrome with multi-organ involvement.
Journal of gastrointestinal oncologyOutcomes of surgical management of carcinoid heart disease in patients with primary gonadal neuroendocrine tumors.
JTCVS openClinical presentation of bone metastases in neuroendocrine tumors: a retrospective cohort study.
Endocrine-related cancer[Primary hepatic neuroendocrine neoplasms: a case series analysis of 10 patients and literature review].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciencesCarcinoid syndrome mimicking irritable bowel syndrome: don't fall into the trap.
Expert review of gastroenterology & hepatologyConcomitant carcinoid heart disease and patent foramen ovale: a case report and review of literature.
Cardio-oncology (London, England)A Rare Case of Idiopathic Angioedema Associated With Amlodipine Use.
CureusA Rare Discovery of Neuroendocrine Tumor: Cardiac Mass.
Journal of community hospital internal medicine perspectivesA Royal Flush: Carcinoid Heart Disease Complicated by Severe Tricuspid and Pulmonic Valve Regurgitation.
CureusDiagnostic Dilemma of a Neuroendocrine Tumour Complicated by Simultaneous Retroperitoneal Fibrosis and Carcinoid Heart Disease in a Perimenopausal Woman.
CureusA deep foundation model for electrocardiogram interpretation: enabling rare disease detection through transfer learning.
European heart journal. Digital healthImpact of treatment on quality of life in neuroendocrine neoplasm survivors.
Endocrine-related cancerNutritional Management of Functioning GEP-NENs.
NutrientsCarcinoid Tumor of the Duodenum Presenting as Iron Deficiency Anemia.
Oman medical journalPulmonary Sclerosing Pneumocytoma Masquerading as a Carcinoid Tumor.
Clinical lung cancerLooking beyond the heart: carcinoid syndrome.
European heart journal. Case reportsA Rare Case of a Neuroendocrine Tumor With Intracardiac Metastasis: Management and Literature Review.
CureusAtypical Presentation of Small Bowel Neuroendocrine Carcinoma Leading to Acute Obstruction.
CureusHiding in Plain Sight: Pulmonic Valve Involvement in Carcinoid Heart Disease.
The American journal of cardiologyOrthotopic transcatheter tricuspid valve replacement in a patient with carcinoid syndrome.
The Journal of invasive cardiologyRed Emitting Fluorescent EuDPA Complex as a Probe for the Detection of Serotonin, A Neurotransmitter.
Journal of fluorescencePFO closure in a patient with hypoxia due to tricuspid valve regurgitation and flow-driven shunt.
BMJ case reportsEchocardiographic Evaluation of Carcinoid Heart Disease.
Journal of the American Society of Echocardiography : official publication of the American Society of EchocardiographyA Tumultuous Journey of Metastatic Pancreatic Neuroendocrine Tumor with Carcinoid Syndrome.
Journal of the ASEAN Federation of Endocrine SocietiesPsychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors.
Translational psychiatryOctreotide infusion pump in patients with functional neuroendocrine tumors and refractory hormonal syndrome.
Endocrine oncology (Bristol, England)Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline.
JCO oncology practice[Treatment options in carcinoid heart disease].
LakartidningenSerum 5-Hydroxyindoleacetic Acid Measurements for the Diagnosis and Follow-up of Carcinoid Syndrome.
The Journal of clinical endocrinology and metabolismPost-marketing Safety Evaluation of Lutathera ( 177 Lu-DOTATATE) : A Pharmacovigilance Analysis of FDA Adverse Event Reporting System.
Clinical nuclear medicineHypertension and Carcinoid Heart Disease as Initial Manifestations of Ovarian Carcinoid Tumor.
JCEM case reportsMesenteric Fibrosis in Neuroendocrine Neoplasms: a Systematic Review of New Thoughts on Causation and Potential Treatments.
Current oncology reportsCongestive Heart Failure and Arrhythmias Among Hospitalized Patients With Carcinoid Syndrome.
CureusFrozen tricuspid valve - A case of a carcinoid syndrome.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of CardiologyExploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis.
Discover oncologyContemporary Management of Severe Carcinoid Heart Disease.
JACC. Case reportsRecurrent transient visual loss in secretory carcinoid tumor.
American journal of ophthalmology case reportsEndocrine paraneoplastic syndromes in lung cancer: A call for clinical vigilance (Review).
Molecular and clinical oncologyBurden of Comorbidities and Concomitant Medications and Their Associated Costs in Patients with Gastroenteropancreatic or Lung Neuroendocrine Tumors: Analysis of US Administrative Data.
Advances in therapyOral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants.
British journal of clinical pharmacologyFunctioning neuroendocrine tumors (NET): Minimum requirements for a NET specialist.
Cancer treatment reviewsThree strikes in a row: a challenging case of carcinoid syndrome.
European heart journalA Rare Case of Gastric Outlet Obstruction Caused by a Duodenal Carcinoid.
CureusFactors Influencing Costs of Cancer Care for Patients with Neuroendocrine Neoplasms.
NeuroendocrinologyMixed Trabecular and Mucinous Carcinoid Arising in the Background of a Mature Ovarian Cystic Teratoma.
CureusThe exceptionally rare phenomenon of well-differentiated colon neuroendocrine tumors.
Journal of neuroendocrinology[An unusual tricuspid regurgitation].
Giornale italiano di cardiologia (2006)The Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors.
CancersA post-modified lanthanide metal-organic frameworks as ratiometric luminescent sensor for the visual detection of 5-hydroxytryptamine.
Journal of hazardous materialsGut microbial and functional alterations lead to metagenomic signatures for midgut neuroendocrine tumor patients and for carcinoid syndrome.
Endocrine-related cancerCarcinoid Heart Disease Associated with Primary Ovarian Carcinoid Tumor: A Rare Presentation.
Heart views : the official journal of the Gulf Heart AssociationExploring Carcinoid Syndrome in Neuroendocrine Tumors: Insights from a Multidisciplinary Narrative Review.
CancersCardiac Surgery and Transcatheter Intervention for Valvular Heart Disease in Carcinoid Syndrome: Risk Factors, Outcomes, and Evolving Therapeutic Strategies.
Journal of cardiovascular development and diseaseSkin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.
CureusSurgical Management of Neuroendocrine Tumor Liver Metastases.
Hematology/oncology clinics of North AmericaCarcinoid heart findings in vasoactive intestinal peptide-secreting tumour.
BMJ case reportsSynchronous bilateral typical pulmonary carcinoid tumours diagnosed by robotic navigation bronchoscopy: A unique case.
Respirology case reportsPercutaneous bicaval valve implantation for severe tricuspid regurgitation due to carcinoid syndrome.
Singapore medical journalCarcinoid syndrome presenting as diffuse violaceous cutaneous flushing.
The British journal of dermatologyCarcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers.
ESMO openAtypical morphoea, a herald of two malignancies: Lung adenocarcinoma and a neuroendocrine tumour.
Journal of scleroderma and related disordersBiomarkers to Inform Prognosis and Treatment for Unresectable or Metastatic GEP-NENs.
JAMA oncologyHorizontal partial laryngectomy for laryngeal neuroendocrine tumor: A case report.
International journal of surgery case reportsEfficacy of Racecadotril in a Patient Affected by a Therapy-Refractory VIPoma and Carcinoid Syndrome.
JCEM case reportsThe challenging differential diagnosis of recurrent flushing episodes: systemic mastocytosis mimicking carcinoid syndrome.
Endokrynologia PolskaManagement of functional neuroendocrine tumors.
Current problems in cancerSevere tricuspid regurgitation and right heart failure secondary to carcinoid heart disease.
Acta cardiologicaA case of carcinoid syndrome after CT guided lung biopsy of a neuroendocrine tumor.
Radiology case reportsSurgical treatment of neuroendocrine tumors.
Current problems in cancerManagement of carcinoid heart disease.
Current problems in cancerIleo-Ileal Intussusception Secondary to Neuroendocrine Tumor in Adult Patient.
The American journal of case reportsAnesthetic key points in a patient with a terminal ileum neuroendocrine tumor and a rare carcinoid left heart disease presented for non-cardiac surgery: case report.
BMC anesthesiologySarcopenia in Patients with Advanced Gastrointestinal Well-Differentiated Neuroendocrine Tumors.
Nutrients[Anaphylactic shock after mistletoe therapy].
Innere Medizin (Heidelberg, Germany)Carcinoid Heart Disease and a Complicated Course of Progressive Gastroenteropancreatic Neuroendocrine Neoplasia: A Case Report.
Case reports in oncology[Appendix ... it's not just appendicitis: neuroendocrine tumors.].
Recenti progressi in medicinaOccult Pancreatic Neuroendocrine Tumor Presenting as Carcinoid Syndrome.
CureusRare Case of Neuroendocrine Metastasis to the Left Ventricle.
JACC. Case reportsCarcinoid crisis: The challenge is still there.
Endocrinologia, diabetes y nutricionEuropean Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours.
Journal of neuroendocrinologyUnmasking Carcinoid Syndrome in a Chronic Obstructive Pulmonary Disease (COPD) Patient: A Rare Presentation with Wheezing and Angioedema.
CureusPrimary Neuroendocrine Tumor of the Testis Associated With Cardiac Symptoms: A Case Report and Literature Review.
CureusUnique Presentation of Adult Ileocecal Intussusception Unveiling a Rare Culprit: A Carcinoid Tumor.
Cureus[Clinical significance of neuroendocrine tumors : Incidence, symptoms, diagnosis, stage, and prognostic factors and their influence on disease management].
Radiologie (Heidelberg, Germany)Carcinoid syndrome with right-sided valve involvement - a case report and review of the literature.
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnostiElevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Frontiers in endocrinologyNormalization of Prediabetic Hemoglobin A1c (HbA1c) Levels After the Surgical Removal of a Serotonin-Secreting Neuroendocrine Tumor.
CureusValue of Surgical Cytoreduction in Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum.
Annals of surgical oncologyLiver-Directed Locoregional Therapies for Neuroendocrine Liver Metastases: Recent Advances and Management.
Current oncology (Toronto, Ont.)Gastric neuroendocrine tumor presenting with carcinoid syndrome.
Revista espanola de enfermedades digestivasPerioperative management of a double valve replacement and coronary artery bypass graft in a patient with carcinoid syndrome; a case report and literature review.
PerfusionComparison of Octreotide and Vasopressors as First-Line Treatment for Intraoperative Carcinoid Crisis.
Annals of surgical oncologyManaging end-stage carcinoid heart disease: A case report and literature review.
World journal of gastrointestinal oncologyA systematic review and meta-analysis of the diagnosis and surgical management of carcinoid heart disease.
Frontiers in cardiovascular medicineFrom biology to clinical practice: antiproliferative effects of somatostatin analogs in neuroendocrine neoplasms.
Therapeutic advances in medical oncologyBenign or by Chance: A Case Report on Incidental Appendectomy Revealing a Neuroendocrine Tumor During Traumatic Exploratory Laparotomy.
CureusThe skin as a window to the gut: A case of carcinoid syndrome.
Clinical case reportsDoes Telotristat Have a Role in Preventing Carcinoid Heart Disease?
International journal of molecular sciencesUse of perioperative telotristat in a patient with carcinoid heart disease.
Endocrinology, diabetes & metabolism case reportsPlasma tryptophan pathway metabolites quantified by liquid chromatography-tandem mass spectrometry as biomarkers in neuroendocrine tumor patients.
Journal of neuroendocrinologyThe cause-and-effect relationship between gut microbiota abundance and carcinoid syndrome: a bidirectional Mendelian randomization study.
Frontiers in microbiologyNET-Induced Carcinoid Heart Disease Affecting Both Tricuspid and Aortic Valves Due to Patent Foramen Ovale and Right/Left Shunt: A Multi-imaging Challenge to Nuclear Medicine.
Clinical nuclear medicineResistant gastroenteropancreatic neuroendocrine tumors: a definition and guideline to medical and surgical management.
Proceedings (Baylor University. Medical Center)A Diagnostic Dilemma: Metastatic Neuroendocrine Tumor Mimicking Hepatocellular Carcinoma.
Rhode Island medical journal (2013)Ovarian metastasis in a patient with neuroendocrine tumour of the small intestine.
Endokrynologia PolskaCarcinoid crisis induced by radioligand therapy: a rare but life-threatening complication in patient with neuroendocrine tumor.
Nuclear medicine review. Central & Eastern EuropePlasma or serum 5-hydroxyindoleacetic acid can be used interchangeably in patients with neuroendocrine tumours.
Scandinavian journal of clinical and laboratory investigationMidgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature.
European journal of cancer (Oxford, England : 1990)Treatment Patterns of Long-Acting Somatostatin Analogs for Neuroendocrine Tumors.
Journal of health economics and outcomes researchSmart dual imprinted Origami 3D-ePAD for selective and simultaneous analysis of vanillylmandelic acid and 5-hydroxyindole-3-acetic acid carcinoid cancer biomarkers using graphene quantum dots coated with dual molecularly imprinted polymers.
TalantaStrongyloidiasis Mimicking Carcinoid Syndrome in an Immunocompetent Host.
CureusCarcinoid heart disease: a potentially fatal complication of carcinoid syndrome.
BMJ case reportsWhat Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators.
Endocrine reviewsLung Carcinoids: A Comprehensive Review for Clinicians.
CancersStructure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Journal of medicinal chemistryPancreatic Neuroendocrine Tumor (Pan-NET) Presented by Abdominal Pain: A Case Report and Literature Review.
Journal of clinical medicineGender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study.
Journal of endocrinological investigationMasquerading as Pneumonia: A Lung Neuroendocrine Tumor Case Report.
CureusSuccessful treatment of facial telangiectasia from carcinoid syndrome with pulsed dye laser therapy.
JAAD case reportsPrevalence, one-year-incidence and predictors of carcinoid heart disease.
Cardiovascular ultrasoundCarcinoid syndrome caused by a pulmonary carcinoid mimics intestinal manifestations of ulcerative colitis: A case report.
World journal of gastroenterologyMetastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease: a case report.
Journal of gastrointestinal oncologyTreatment of idiopathic anaphylaxis with dupilumab: a case report.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical ImmunologyA Case of Functional Bowel Disease Misdiagnosed as Carcinoid Syndrome.
ACG case reports journalImproving outcomes in carcinoid heart disease - learning from a single centre.
Nuclear medicine communicationsCarcinoid syndrome-Symptoms and therapeutic approaches.
Hellenic journal of nuclear medicineHigh Tumor Uptake on 18F-FDOPA PET/CT Indicates Poor Prognosis in Patients with Metastatic Midgut Neuroendocrine Tumors: A Study from the Groupe d'étude des Tumeurs Endocrines and ENDOCAN-RENATEN Network.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineUrinary 5-Hydroxyindolacetic Acid Measurements in Patients with Neuroendocrine Tumor-Related Carcinoid Syndrome: State of the Art.
CancersConventional Transarterial Chemo embolization Using Streptozocin in Patients with Unresectable Neuroendocrine Liver Metastases.
CancersCombination Systemic Therapies in Advanced Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs): A Comprehensive Review of Clinical Trials and Prospective Studies.
BiologyA case of carcinoid syndrome probably exacerbated by hemodialysis in which prochlorperazine maleate was effective.
CEN case reportsPatent foramen ovale in carcinoid heart disease: The potential role for and risks of percutaneous closure prior to cardiothoracic surgery.
Journal of neuroendocrinologyEuropean Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes.
Journal of neuroendocrinologyAppendiceal Neuroendocrine Neoplasms: A Comprehensive Review.
Journal of computer assisted tomographyA Comprehensive Review on Neuroendocrine Neoplasms: Presentation, Pathophysiology and Management.
Journal of clinical medicineNT-proBNP as a neuroendocrine tumor biomarker: beyond heart failure.
Endocrine connectionsHealth care resource use and costs among patients with carcinoid syndrome in France: Analysis of the National Health Insurance Database.
Clinics and research in hepatology and gastroenterologyThe role of serotonin inhibition within the treatment of carcinoid syndrome.
Endocrine oncology (Bristol, England)Breakthrough Symptoms Remain an Unmet Need in Symptomatic Patients With Neuroendocrine Tumors and Carcinoid Syndrome.
PancreasSurgery Improves Patient-Reported Outcomes in Patients with Intestinal and Pancreatic NETs: A Prospective Analysis.
Annals of surgical oncologyEffective strategies for adequate control of hormonal secretion in functioning neuroendocrine neoplasms.
Best practice & research. Clinical endocrinology & metabolismLate-stage diagnosis of carcinoid heart disease due to lack of access to health care.
Cardio-oncology (London, England)Therapy Sequencing in Patients With Advanced Neuroendocrine Neoplasms.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual MeetingCarcinoid Heart Disease Management: A Multi-Disciplinary Collaboration.
The oncologistPrimary Well-Differentiated Neuroendocrine Tumor of the Kidney.
Journal of kidney cancer and VHLTesticular Neuroendocrine Tumors: A Case Report and Literature Review.
CureusSmall bowel neuroendocrine tumours - casting the net wide.
Current opinion in gastroenterologyImpact of Atrial Fibrillation on Patients With Carcinoid Syndrome: A National Inpatient Sample Analysis.
The American journal of cardiologyTargeting neuroendocrine tumors with octreotide and lanreotide: Key points for clinical practice from NET specialists.
Cancer treatment reviewsInhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth in vivo.
bioRxiv : the preprint server for biologyOutcome of carcinoid heart syndrome in patients enrolled in the SwissNet cohort.
BMC cancerSporadic pancreatic neuroendocrine neoplasms: A retrospective clinicopathological and outcome analysis from a Latvian study group.
Frontiers in surgeryCarcinoid syndrome in a HIV-infected patient: where you least expect it.
AIDS (London, England)Carcinoid heart disease in patients with midgut neuroendocrine tumours.
Journal of neuroendocrinologyPrescribing Characteristics of Octreotide Immediate-Release and Long-Acting Release in Patients with Neuroendocrine Tumors.
The oncologistCarcinoid Heart Disease-Induced Right-Sided Heart Failure as a Culprit for Significant Ascites.
Case reports in gastroenterologyDiagnosis and management of neuroendocrine tumours.
Clinical medicine (London, England)Carcinoid syndrome and somatostatin analogues.
Revista espanola de enfermedades digestivasTelotristat Etiprate alleviates rheumatoid arthritis by targeting LGALS3 and affecting MAPK signaling.
Intractable & rare diseases researchLiver transplantation in gastroenteropancreatic neuroendocrine tumors.
Frontiers in oncologyThe Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis.
Journal of personalized medicineCarcinoid Syndrome: Preclinical Models and Future Therapeutic Strategies.
International journal of molecular sciencesAnalysis of Patients with NET G1/G2 Neuroendocrine Tumors of the Small Intestine in the Course of Carcinoid Heart Disease-A Retrospective Study.
Journal of clinical medicineBioprosthetic valve monitoring in patients with carcinoid heart disease.
Frontiers in cardiovascular medicineDiscovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
ACS medicinal chemistry lettersBalancing carcinoid crisis and right ventricular dysfunction during tricuspid and pulmonic valve replacement for carcinoid heart disease: A case report.
International journal of surgery case reportsNeuroendocrine Tumor Presenting as Hypoxic Respiratory Failure in a Patient with Patent Foramen Ovale.
The Brown journal of hospital medicineAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Oxalate nephropathy from untreated pancreatic insufficiency in a neuroendocrine tumour patient.
- Real-World Observational Study of Somatostatin Analogs and Rescue Medication Usage for Neuroendocrine Tumors in Canada.
- Recurrent ventricular asystole during octreotide infusion in a patient with pancreatic neuroendocrine tumor: a case report.
- Determining Prognosis in Patients With Carcinoid Syndrome: A Retrospective Single-Center Cohort Study.
- Multivalvular Cardiac Involvement from Giant Hepatic Metastases of an Ileal Neuroendocrine Tumor.
- Neuroendocrine Tumors and Pregnancy: The French PregNET Study.
- Impact of Symptom Phenotype on Surgical Quality and Survival in Small-Bowel Neuroendocrine Tumours: A Quality Metrics Analysis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:100093(Orphanet)
- MONDO:0100347(MONDO)
- GARD:5994(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q339547(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
