Raras
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Meduloepitelioma
ORPHA:251883DOENÇA RARA

Câncer ocular, câncer de olho ou cancro oftamológico é uma neoplasia maligna que afeta alguma das estruturas do globo ocular. Os cânceres primários no olho são incomuns e podem se originar da conjuntiva, córnea, úvea, retina, do nervo óptico ou em estruturas anexas como pálpebra e canal lacrimal. Cânceres secundários (metástases) de um câncer de pulmão ou câncer de mama também podem fixar-se no olho.

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Introdução

O que você precisa saber de cara

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Tumor raro do sistema nervoso central, originado de células neuroepiteliais primitivas. Apresenta-se com sintomas neurológicos progressivos, dependendo da localização e tamanho.

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Últimos 10 anos200publicações
Pico202489 papers
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2023Hoje · 2026🧪 2005Primeiro ensaio clínico📈 2024Ano de pico
Publicações por ano (últimos 10 anos)

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America2026 Mar 24

Organ development and function are orchestrated by intricate transcriptional circuits. Here, we present a comprehensive atlas profiling 1,904 transcription regulators in the brain, cerebellum, heart, kidney, liver, ovary, and testis of fetal, neonatal, and adult mice. Using this dataset, we uncover Thymocyte Selection-Associated High Mobility Group Box Family Member 3 (TOX3) as a potential coactivator of Atoh1 in cerebellar granule neuron progenitors (GNPs). Tox3-deficient mice display severe ataxia and cerebellar hypoplasia, driven by depletion of GNPs, diminished Atoh1 expression, and impaired primary cilia. Single-nucleus RNA-sequencing analyses reveals compromised maintenance of the progenitor pool. TOX3 is also highly expressed in subsets of medulloblastoma, and its deletion reduces cerebellar neoplasia and prolongs survival in a mouse model. Mechanistically, how lineage-defining factors such as Atoh1 drive robust gene expression despite weak intrinsic transactivation activity remains unclear. We show that Tox3 physically associates with Atoh1 and co-occupies shared regulatory elements, converting an otherwise weak single-copy Atoh1-responsive E-box into a highly active enhancer that drives transcriptional activation by up to 120-fold, including at an ultraconserved E-box downstream of Atoh1 itself. Cross-species single-cell comparisons further show an association between Tox3 expression and cerebellum expansion during vertebrate evolution. Together, this work supports Tox3 as a critical Atoh1 coactivator in cerebellar development, tumorigenesis, and evolution, while providing an atlas and screening strategy as a valuable resource for exploring novel transcriptional regulators in organogenesis and tissue physiology.

#2

Temporal clustering of neuroblastic tumours in children and young adults from Scotland.

Environmental health : a global access science source2026 Jan 24

Neuroblastic tumours (neuroblastoma and ganglioneuroblastoma) are the most common childhood solid tumours outside the central nervous system, with a median age of diagnosis of 2 years. Temporal clustering of neuroblastic tumours in northern England and Ontario, Canada has been previously reported. We extracted data from the Scottish Cancer Registry to determine whether there was evidence of temporal clustering of neuroblastic tumours. Cases diagnosed in children and young adults aged 0-24 years between 2000 and 2020 were analysed. A modified version of the Potthoff-Whittinghill method was used to test for temporal clustering. Estimates of extra-Poisson variation (EPV) and standard errors (SE) were derived. One hundred and sixty-one cases of neuroblastic tumours, aged 0-24 years, were diagnosed during the study period. Overall, there was statistically significant temporal clustering between years within the full study period (EPV = 9.13, SE = 0.22, P < 0.001). In addition, for cases aged < 18 months, there was significant temporal clustering between months within quarters (EPV = 0.77, SE = 0.41, P = 0.044). For cases aged 18 months - 24 years, there was significant temporal clustering between fortnights within months (EPV = 1.00, SE = 0.47, P = 0.012). The finding of temporal clustering is consistent with the involvement of one or more, as yet unknown, transient environmental agents in the aetiology of neuroblastic tumours.

#3

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio-Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse.

Pediatric blood &amp; cancer2026 Apr

Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available. Novel therapeutic approaches, such as intraventricular radio-immunotherapy with 131I-omburtamab (Omb), have been developed. In this study, we report a retrospective, single-tertiary center analysis of a 23-year cohort of NB patients with CNS metastases, highlighting current treatment strategies. Retrospective data analysis of all NB patients with CNS metastases treated at Hospital Sant Joan de Déu, Barcelona, from January 2000 to January 2023. Patient characteristics at diagnosis, first-line treatment, relapse patterns, and CNS metastasis management were analyzed in search of risk variables and survival outcomes. CNS metastases at relapse were identified in 39/185 (21.1%) patients. Median age at diagnosis was 2.7 years, and 24/39 were male. Stage 4 NB with multisite compartment metastases accounted for most cases (92.2%). CNS events occurred predominantly at first relapse (29/39, 74.4%) and with neurological symptoms (23/38, 60.5%). MCYN amplification and concomitant extra-CNS metastases at CNS relapse were associated with poorer overall survival (OS) (p = 0.018 and p = 0.0059, respectively). Neurological symptoms upon relapse significantly increased the risk for subsequent CNS events (p = 0.028). Curative-intent treatment was attempted in 34/39 (87.2%) patients. After adjusting for immortal time bias, RT plus Omb significantly improved OS (p < 0.0001). In our experience, MYCN amplification and concomitant extra-CNS metastases at CNS relapse significantly decrease OS. Multimodal treatment, including 131I-omburtamab radioimmunotherapy, significantly improves survival outcomes.

#4

A functionally relevant model for interrogating brain tumor-endothelial cell interactions.

Journal of neuroscience methods2026 Mar

Intercellular interactions, particularly those between tumor cells and the surrounding vasculature, are central to the biology of the tumor microenvironment. Approaches for studying these interactions often rely on limited patient samples or time- and resource-intensive xenograft tissues in combination with histological or single-cell omics profiling. While informative, these models capture only static snapshots and limit mechanistic interrogation. Studying the mechanisms behind these interactions requires viable co-culture models for culturing different cell types together in vitro, while preserving the phenotypic integrity of each cell type. To achieve this, we developed and validated optimal in vitro culture conditions to support the co-culture of human Group 3 medulloblastoma (G3 MB) cells and microvascular brain endothelial cells (BECs) as an ideal screening model for mechanistic and interventional studies. Supported by a new optimized 1:1 mixed media formulation, this model preserves native cellular morphology and phenotypic characteristics. When cultured alone in the new optimized media, G3 MB cells retained expression of stemness markers (SOX2 & OTX2), self-renewal capacity, and undifferentiated morphology, while BECs retained tight junction formation and migratory behavior. This co-culture platform permits real-time, dynamic, and mechanistic studies of tumor-endothelial cell interactions, overcoming the limitations of fixed-tissue analyses and facilitating precise experimental manipulation. This well-characterized model provides a physiologically and functionally relevant platform for further dissecting the reciprocal interactions present between various brain cancer cells and vascular endothelial cells, supporting the development of targeted therapeutic strategies and advancing our understanding of brain tumor biology.

#5

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

Nature biomedical engineering2026 Mar

Biofluid flow generates fluid shear stress (FSS), a mechanical force widely present in the tissue microenvironment. How brain tumour growth alters the conduit of biofluid and impacts FSS-regulated cancer progression is unknown. Dissemination of medulloblastoma (MB) cells into the cerebrospinal fluid initiates metastasis within the central nervous system. Here, by simulating cerebrospinal fluid dynamics based on magnetic resonance imaging of patients with MB, we discover that FSS is elevated at the cervicomedullary junction. MB-relevant FSS promotes metastasis along the mouse spinal cord. Mechanistically, FSS induces metastatic cell behaviours, including weakened cell-substrate adhesion, increased motility, cell clustering and plasma membrane localization of glucose transporter 1 (GLUT1) to enhance glucose uptake. FSS is perceived by the mechanosensitive ion channel PIEZO2, which drives actomyosin contractility-dependent GLUT1 recruitment at the plasma membrane. Genetic targeting of PIEZO2 or pharmacologic inhibition of GLUT1 mitigates metastasis. Collectively, these findings define a targetable FSS-activated mechano-metastatic cascade for the treatment of MB metastasis.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1 artigos no totalmostrando 200

2026

A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America
2026

Bilateral blindness from optic chiasm metastasis as the initial presentation of stage 4 neuroblastoma: A case report.

Medicine
2026

Extracranial teratoid medulloepithelioma: A pelvic observation with genetic and epigenetic findings.

Virchows Archiv : an international journal of pathology
2025

Primary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis.

Archives of Iranian medicine
2026

A Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors.

Actas espanolas de psiquiatria
2026

Primary CNS Neuroblastoma, FOXR2-Activated: Clinicopathological Study of Two Cases With Immunohistochemical Characterization and Literature Review.

Neuropathology : official journal of the Japanese Society of Neuropathology
2026

[Deep Learning-Based Automated Segmentation Algorithms of Brain and Vertebral Substructures for Radiotherapy in Pediatric Medulloblastoma].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
2025

Simultaneous occurrence of bilateral retroperitoneal neuroblastoma and bifocal malignant mixed germ cell tumor in a pediatric patient with 16p11.2 microdeletion syndrome: a case report.

Frontiers in endocrinology
2026

Temporal clustering of neuroblastic tumours in children and young adults from Scotland.

Environmental health : a global access science source
2026

Inequalities in survival among children with central nervous system cancers and neuroblastoma: A population-based study.

Cancer epidemiology
2026

Central Nervous System Metastases from Pediatric Solid Tumors: A Single-Institution Study.

World neurosurgery
2026

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio-Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse.

Pediatric blood &amp; cancer
2026

Tumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development.

Disease models &amp; mechanisms
2025

Outcomes and Toxicity of Adult Medulloblastoma Treated with Pediatric Multimodal Protocols: A Single-Institution Experience.

Oncology research
2025

L-Theanine Uptake via Solute Carrier Family 38 Member 1 Inhibits Neuroblastoma Cell Growth.

Neurochemical research
2026

A functionally relevant model for interrogating brain tumor-endothelial cell interactions.

Journal of neuroscience methods
2025

A case report of atypical teratoid/rhabdoid tumor and pituitary adenoma collision tumor in the sellar region.

Frontiers in surgery
2025

Transient visual loss following endoscopic third ventriculostomy in a child with a posterior fossa tumour: consideration of intracranial pressure control.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2026

DNA Methylation Profiling Classifies and Reveals Origin of Gynecologic Central Nervous System-Like Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
2025

Paediatric Strategy Forum for medicinal product development of agents targeting GD2 ganglioside in children and adolescents with cancer.

European journal of cancer (Oxford, England : 1990)
2026

Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells.

Archives of toxicology
2025

Inflammation accelerates metastasis: Medulloblastoma leptomeningeal dissemination.

Developmental cell
2026

Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies.

Molecular diagnosis &amp; therapy
2025

The antidepressant-like properties of corilagin on SH-SY5Y neuroblastoma cells and a forced swimming test animal model.

Neuroscience
2026

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology.

Neuro-oncology
2025

Integration of artificial intelligence in the clinical management of medulloblastoma: from precision diagnosis to dynamic prognosis.

Expert review of neurotherapeutics
2025

Cerebrospinal Fluid-Derived Small Extracellular Vesicles May Better Reflect Medulloblastoma Proteomes than Those from Blood Plasma.

International journal of molecular sciences
2025

Extraneural and extracranial metastatic astrocytoma with primitive neuroectodermal component: a case report.

Journal of medical case reports
2025

Revisiting pediatric HGGs and PNETs according to the WHO CNS5 criteria: A clinical and genomic retrospective analysis.

Neuro-oncology advances
2025

Only the strong survive: therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis.

Molecular oncology
2025

Opposite patterns of association of TWIST1 expression with patient survival in SHH and Group 4 medulloblastoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2026

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

Nature biomedical engineering
2025

G-quadruplexes as a source of vulnerability in BRCA2-deficient granule cell progenitors and medulloblastoma.

Proceedings of the National Academy of Sciences of the United States of America
2025

Proton versus photon radiation therapy for pediatric medulloblastomas: a systematic review and meta-analysis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis.

Frontiers in immunology
2026

How is rosette formation in brain tumours linked with cerebrospinal fluid spread?

Brain tumor pathology
2025

Outcomes of Infants and Young Children With CNS Embryonal Tumors Using Pre-Irradiation Chemotherapy: A Decade Long Experience.

Cancer medicine
2025

Long-term survival and cure fraction estimates for paediatric central nervous system tumours in 31 European countries (EUROCARE-6): a population-based study.

The Lancet. Oncology
2025

The Role of 18 F-AlF-NOTA-Octreotide PET/CT in the Evaluation of Central Nervous System Metastases in Neuroblastoma : A Preliminary Study.

Clinical nuclear medicine
2025

Medulloblastoma: biology and immunotherapy.

Frontiers in immunology
2025

Tamibarotene promotes differentiation of neuroblastoma SH-SY5Y cells into neurons, which is associated with activation of the PI3K/AKT signaling pathway.

BMC neuroscience
2025

A head-to-head prospective comparative analysis of 68Ga-DOTATATE PET/CT and 123I-MIBG SPECT/CT in central nervous system metastases of neuroblastoma and ganglioneuroblastoma.

European journal of nuclear medicine and molecular imaging
2025

Updates on cancer vaccines in brain cancer: Advances in neuroblastoma, delivery systems, and emerging technologies.

Human vaccines &amp; immunotherapeutics
2025

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process.

Developmental cell
2025

Extent of Resection and Role of Adjuvant Radiotherapy in Olfactory Neuroblastoma Without Definite Radiologic Evidence of Dural Invasion.

International forum of allergy &amp; rhinology
2025

Growth Dynamics of Brain Tumor Through the Lens of MT-Weighted MRI.

Methods in molecular biology (Clifton, N.J.)
2025

Nonthyroidal Illness Syndrome in a Noncritically Ill Child.

Pediatrics
2025

Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum.

Pediatric blood &amp; cancer
2025

Ketamine-Ethanol Combination Decreases Reduced Glutathione Levels and Activates both Intrinsic and Extrinsic Apoptotic Pathways Prior to Neuronal Death in SH-SY5Y Cells.

Neurotoxicity research
2025

Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model.

Cancer treatment and research communications
2025

Neuroprotective effects of acetophenone dimers from Acronychia pedunculata on human neuroblastoma SH-SY5Y cells in glutamate-induced apoptosis.

Journal of natural medicines
2025

COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice.

Journal of controlled release : official journal of the Controlled Release Society
2025

Exposure of human neuroblastoma SH-SY5Y cells to amphetamine-type stimulants leads to oxidative-antioxidative imbalance associated with DNA damage and acetylcholine antagonism.

Chemico-biological interactions
2025

Postoperative Hyperglycemia with Ketosis Sans Acidemia in a Child Immediately Following Fourth Ventricular Medulloblastoma Resection: Anesthetic Concerns and Intensive Care Management.

Neurology India
2025

Haploidentical stem cell transplantation in newly diagnosed high-risk neuroblastoma: Results from a single-arm, prospective study from India.

Indian journal of cancer
2025

Enhanced plasma and brain concentrations and medulloblastoma cytotoxicity of asciminib and nilotinib by P-glycoprotein inhibition with tariquidar.

Anti-cancer drugs
2025

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth.

Nature cell biology
2025

Therapeutic approaches for targeting the pediatric brain tumor microenvironment.

Drug delivery and translational research
2025

Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells.

Scientific reports
2025

FOXR2 activation is not exclusive of CNS neuroblastoma.

Neuro-oncology
2025

Expect the unexpected: neuroblastoma in a patient with the VACTERL association.

BMJ case reports
2025

Clinicopathologic and molecular characterization of primitive neuroectodermal tumors (PNET) in the female genital tract: a retrospective study of 8 cases.

Human pathology
2025

The intersections between neuroscience and medulloblastoma.

Cancer letters
2025

Neuroendoscopic Surgical Treatment of Cerebellar Vermis Tumors in Pediatric Patients: A Case Series.

Pediatric neurosurgery
2025

miR-512-3p as a Potential Biomarker of Poor Outcome in Pediatric Medulloblastoma.

Cerebellum (London, England)
2025

Evaluating the efficacy of radiotherapy in patients with embryonal tumor with multilayered rosettes: A systematic review and meta-analysis.

Neuro-oncology practice
2025

Global, regional, and national burden of neuroblastoma and peripheral nervous system tumours in individuals aged over 60 from 1990 to 2021: a trend analysis of global burden of disease study.

Journal of health, population, and nutrition
2025

A Phase II Trial of Naxitamab plus Stepped-up Dosing of GM-CSF for Patients with High-Risk Neuroblastoma in First Complete Remission.

Clinical cancer research : an official journal of the American Association for Cancer Research
2025

DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma.

Acta neuropathologica communications
2025

Molecular classification of medulloblastoma using immunohistochemistry: A single centre study.

Annals of diagnostic pathology
2025

Infradentate Approach to the Fourth Ventricle with Tubular Retraction System for Medulloblastoma: Feasibility of a Minimally Invasive Technique to Avoid Anatomical Complications in a Pediatric Patient.

Pediatric neurosurgery
2025

Intra-tumoral hemorrhage after endoscopic third ventriculostomy in a child with WNT-activated medulloblastoma: case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2025

Immunomodulatory role of exosome-derived content in pediatric medulloblastoma: a molecular subgroup perspective.

Human cell
2025

Perivascular space imaging during therapy for medulloblastoma.

PloS one
2025

Deep learning to decode sites of RNA translation in normal and cancerous tissues.

Nature communications
2025

Transcription Factor Fingerprint Provides Clues for Brain Tumor Cell of Origin.

Cancer research
2025

Impact of Pediatric Posterior Fossa Tumor Treatments on Working Memory Tracts Using Resting-State fMRI and Tractography.

Journal of neuroimaging : official journal of the American Society of Neuroimaging
2025

False-Positive Uptake of 123 I-MIBG in the Basal Ganglion in a Pediatric Neuroblastoma Patient.

Clinical nuclear medicine
2025

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.

Nature genetics
2024

Balancing CIK Cell Cancer Immunotherapy and PPAR Ligands: One Potential Therapeutic Application for CNS Malignancies.

Cancer medicine
2025

Pineal Gland Activity in Advanced-Stage Pediatric Neuroblastoma Patients on 68 Ga-DOTATATE PET/CT.

Clinical nuclear medicine
2025

Investigating miR-9 and miR-222 in CSF and Plasma of Neuroblastoma Patients as Metastatic and Apoptotic-Related Markers.

Cell biochemistry and biophysics
2024

CP ANGLE MEDULLOBLASTOMA WITH SUPRATENTORIAL DROP METS.

Journal of Ayub Medical College, Abbottabad : JAMC
2024

Differential Replication and Oncolytic Effects of Zika Virus in Aggressive CNS Tumor Cells: Insights from Organoid and Tumoroid Models.

Viruses
2024

Understanding Aβ25-35 peptide altered exosomal proteome and associated pathways linked with the Alzheimer's disease pathogenesis using human neuroblastoma SH-SY5Y Cells.

Metabolic brain disease
2024

The Abnormal Proliferation of Midbrain Dopamine Cells From Human Pluripotent Stem Cells Is Induced by Exposure to the Tumor Microenvironment.

CNS neuroscience &amp; therapeutics
2025

Cost-effectiveness analysis for multi adverse events of proton beam therapy for pediatric medulloblastoma in Japan.

Journal of radiation research
2025

Phenotypic and oncological insights in ANNA1 autoimmunity: Age stratification and biomarker analysis.

Annals of clinical and translational neurology
2025

Pathologic dural invasion is associated with regional recurrence in olfactory neuroblastoma: A multi-institutional study.

International forum of allergy &amp; rhinology
2025

FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma.

Cancer research
2024

Metabolomic profiling of childhood medulloblastoma: contributions and relevance to diagnosis and molecular subtyping.

Journal of cancer research and clinical oncology
2025

Concurrent Intracranial and Spinal Dural Metastases Demonstrated by 68 Ga-DOTATATE PET/CT With Negative 123 I-MIBG SPECT/CT in a Pediatric Neuroblastoma Patient.

Clinical nuclear medicine
2024

Overcoming the limits of pediatric brain tumor radiotherapy: The use of preclinical 3D models.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
2024

Diverse Engraftment Capability of Neuroblastoma Cell Lines in Zebrafish Larvae.

Zebrafish
2024

A Case Series of Children With Medulloblastoma Depicting the Disparities in Care and the Challenges in the Detection and Treatment of Pediatric Central Nervous System Tumors in Low-Resource Settings: A Case Study of Uganda.

Pediatric neurology
2024

Direct Administration of Chemotherapy and Other Agents into the Fourth Ventricle to Treat Recurrent Malignant Brain Tumors in Children.

Advances and technical standards in neurosurgery
2025

Arrested development: the dysfunctional life history of medulloblastoma.

Genes &amp; development
2025

Treatment of Medulloblastoma in the Adolescent and Young Adult Population: A Systematic Review.

Journal of adolescent and young adult oncology
2024

Tannic acid protects neuroblastoma cells against hydrogen peroxide - triggered oxidative stress by suppressing oxidative stress and apoptosis.

Brain research
2024

Evolution of Proton Radiation Therapy Brainstem Constraints on the Pediatric Proton/Photon Consortium Registry.

Practical radiation oncology
2024

Methylglyoxal induces death in human brain neuronal cells (SH-SY5Y), prevented by metformin and dapagliflozin.

Journal of diabetes and its complications
2025

A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma.

Head &amp; neck
2024

Primary central nervous system neuroblastoma mimicking a meningioma: A case report.

Journal of postgraduate medicine
2024

Medulloblastoma subgrouping at first sight.

Cancer cell
2024

Non-C19MC-altered embryonal tumor with multilayered rosettes in a young woman with DICER1 syndrome: case report and review of the literature.

Pathologica
2024

Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.

Cell
2025

Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells.

Brain pathology (Zurich, Switzerland)
2024

Deep learning models for predicting the survival of patients with medulloblastoma based on a surveillance, epidemiology, and end results analysis.

Scientific reports
2024

Arterial Spin-Labeling Perfusion Lightbulb Sign: An Imaging Biomarker of Pediatric Posterior Fossa Hemangioblastoma.

AJNR. American journal of neuroradiology
2024

Using diffusion MRI to understand white matter damage and the link between brain microstructure and cognitive deficits in paediatric medulloblastoma patients.

European journal of radiology
2024

Evolutionary Strategies AI Addresses Multiple Technical Challenges in Deep Learning Deployment: Proof-of-Principle Demonstration for Neuroblastoma Brain Metastasis Detection.

Journal of imaging informatics in medicine
2024

Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth.

Cell death and differentiation
2024

Evolving driver mutations in adult-onset SHH-medulloblastoma originated from radiological cerebellar abnormality.

Journal of neuropathology and experimental neurology
2024

NR1D1-transactivated lncRNA NUTM2A-AS1 promotes chemoresistance and immune evasion in neuroblastoma via inhibiting B7-H3 degradation.

Journal of cellular and molecular medicine
2024

Cerebellar Mutism Syndrome and Dentato-Thalamo-Cortical Tract Disruption in Diffusion Tractography Following Surgery for Medulloblastoma.

Radiology
2024

Development of Orthotopic Patient-Derived Xenograft Models of Pediatric Intracranial Tumors.

Methods in molecular biology (Clifton, N.J.)
2024

Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells.

Neuromolecular medicine
2024

Spinal Cord Medulloepithelioma in a Cat.

Veterinary sciences
2024

Multifunctional Fluoropolymer-Engineered Magnetic Nanoparticles to Facilitate Blood-Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2024

Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells.

Journal of ethnopharmacology
2024

miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression.

Cancer gene therapy
2024

Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells.

PloS one
2024

Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2024

The pivotal role of irradiation-induced apoptosis in the pathogenesis and therapy of medulloblastoma.

Cancer reports (Hoboken, N.J.)
2024

Secondary cerebro-cerebellar and intra-cerebellar dysfunction in cerebellar mutism syndrome.

Neuro-oncology
2024

A Rare Case of Abnormal Diffuse Brain Uptake on an 123I MIBG Scan in a Patient With High-Risk Neuroblastoma.

Clinical nuclear medicine
2024

Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells.

Biological &amp; pharmaceutical bulletin
2024

Clinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center.

Journal of cancer research and therapeutics
2024

Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats.

Journal of toxicology and environmental health. Part A
2024

Interleukin 3 Inhibits Glutamate-Cytotoxicity in Neuroblastoma Cell Line.

Neurochemical research
2024

Preoperative 11 C-Methionine PET-MRI in Pediatric Infratentorial Tumors.

Clinical nuclear medicine
2024

Direct Synthesis of α- and β-2'-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation.

Journal of the American Chemical Society
2024

Incidence, survival, and mortality of cancer in children and young adolescents in Belgium and the Netherlands in 2004-2015: A comparative population-based study.

International journal of cancer
2024

PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas.

Journal of clinical pathology
2024

Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex.

Journal of the American Heart Association
2024

Plasma ctDNA Monitoring of a PTCH1-Mutant Metastatic Adult Medulloblastoma Showing a Durable Benefit With Vismodegib.

The oncologist
2024

Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction.

Journal of medicinal chemistry
2024

CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.

CNS neuroscience &amp; therapeutics
2024

Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke.

Journal of controlled release : official journal of the Controlled Release Society
2024

CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication - evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours.

Acta neuropathologica communications
2024

18F-FDG PET/CT Imaging for Treatment Response Assessment of Cardiac Primitive Neuroectodermal Tumor.

Molecular imaging and radionuclide therapy
2024

HERV-K (HML-2) Envelope Protein Induces Mitochondrial Depolarization and Neurotoxicity via Endolysosome Iron Dyshomeostasis.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2024

SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2024

Bioadhesive Hyaluronic Acid-Based Hydrogels for Spinal Cord Injury.

Biomacromolecules
2024

Epidemiology and economic burden of Von Hippel-Lindau Disease-associated central nervous system hemangioblastomas and pancreatic neuroendocrine tumors in the United States.

Orphanet journal of rare diseases
2024

Lysine ε-aminolysis and incorporation of sulfhydryl groups into human brain tau 4R/1N and 306VQIVYK311 enhances the formation of beta structures and toxicity.

International journal of biological macromolecules
2024

Cerebellar cognitive affective syndrome with long-term features of autism spectrum disorder: evidence in a 9-year-old girl after vermian medulloblastoma surgery.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
2024

The effectiveness of diffusion kurtosis imaging metrics for distinguishing between brainstem glioma and cerebellar medulloblastoma.

La Clinica terapeutica
2024

Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis.

Environmental toxicology
2024

Brain Tumor Imaging in Adolescents and Young Adults: 2021 WHO Updates for Molecular-based Tumor Types.

Radiology
2024

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial.

Genome medicine
2024

Successful use of tacrolimus for treatment-refractory neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome: A case series.

Pediatric blood &amp; cancer
2024

Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines.

European journal of medicinal chemistry
2024

Brain and Brain Stem Necrosis After Reirradiation for Recurrent Childhood Primary Central Nervous System Tumors: A PENTEC Comprehensive Review.

International journal of radiation oncology, biology, physics
2024

Rare incidence of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma: A case report and review of the literature.

International journal of surgery case reports
2024

HAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection.

Antiviral research
2024

Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect.

Scientific reports
2024

Developmental basis of SHH medulloblastoma heterogeneity.

Nature communications
2024

Carbon disulfide induces accumulation of TDP-43 in the cytoplasm and mitochondrial dysfunction in rat spinal cords.

Cerebral cortex (New York, N.Y. : 1991)
2024

Successful peripheral blood stem cell harvesting for two pediatric cases of atypical teratoid/rhabdoid tumor with low bodyweight.

Pediatric blood &amp; cancer
2023

Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2.

Journal of integrative neuroscience
2023

Embryonal Tumor with Multilayered Rosettes, NOS of Cervical Spinal Cord.

Neurology India
2024

Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats.

Journal of ethnopharmacology
2023

Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures.

Cellular and molecular neurobiology
2025

Intracranial leptomeningeal CNS ganglioneuroblastoma. First report and review of the literature.

British journal of neurosurgery
2024

Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression.

Ecotoxicology and environmental safety
2024

Maternal Prenatal Use of Alcohol, Tobacco, and Illicit Drugs and Associations with Childhood Cancer Subtypes.

Cancer epidemiology, biomarkers &amp; prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
2023

The unique immune ecosystems in pediatric brain tumors: integrating single-cell and bulk RNA-sequencing.

Frontiers in immunology
2024

CSF cytology of common primary CNS neoplasms categorized by CNS WHO 2021.

Cytopathology : official journal of the British Society for Clinical Cytology
2024

Adolescents and Young Adults With Cancer: CNS Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2024

Role of Basal Forebrain Neurons in Adrenomyeloneuropathy in Mice and Humans.

Annals of neurology
2024

Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma.

International journal of radiation oncology, biology, physics
2023

Identification of Molecular Mechanisms Responsible for the MMP-9-1562C/T Dependent Differential Regulation of Matrix Metalloproteinase-9 Expression in Human Neuron-like Cells.

Genes
2023

Neoadjuvant Chemotherapy with Laser Interstitial Thermal Therapy in Central Nervous System Neuroblastoma: Illustrative Case and Literature Review.

Brain sciences
2023

Natural Terpenes Inhibit the Cytopathogenicity of Naegleria fowleri Causing Primary Amoebic Meningoencephalitis in the Human Cell Line Model.

ACS chemical neuroscience
2024

Synthesis and molecular docking simulation of new benzimidazole-thiazole hybrids as cholinesterase inhibitors.

Archiv der Pharmazie
2024

Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling.

International journal of radiation biology
2023

Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.

Acta biochimica Polonica
2024

Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease.

Journal of ethnopharmacology
2024

Embryonal tumor with multilayered rosettes arising from the internal auditory canal of an adult: Illustrative case with molecular investigations.

Neuropathology : official journal of the Japanese Society of Neuropathology
2023

Engineering subarachnoid trabeculae with electrospun poly(caprolactone) (PCL) scaffolds to study leptomeningeal metastasis in medulloblastoma.

Biomaterials advances
2024

Dosimetric impact of adding non-coplanar arcs for scalp-avoidance whole-brain irradiation with volumetric-modulated arc radiotherapy on scalp dose reduction in pediatric patients with medulloblastomas.

Journal of applied clinical medical physics
2024

Synergetic effect of matrine on the catalytic scFv antibody HS72 in vitro and in mice with Alzheimer disease pathology.

Neuropharmacology
2023

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.

Molecular brain
2023

Distinct tau folds initiate templated seeding and alter the post-translational modification profile.

Brain : a journal of neurology
2023

RETRACTED: Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity.

International journal of molecular sciences
2023

Identification of Uncaria rhynchophylla in the Potential Treatment of Alzheimer's Disease by Integrating Virtual Screening and In Vitro Validation.

International journal of molecular sciences
2024

Fatal brainstem injury following proton radiation in a patient with medulloblastoma and a germline variant in RNF213.

Pediatric blood &amp; cancer
2023

Potential Effects of Alpha-Glycosyl Isoquercitrin on Memory by Altering the Gut Microbiota-Blood-Brain Axis in Mice.

Journal of agricultural and food chemistry
2023

Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism.

Current topics in medicinal chemistry
2024

Current practice of cancer predisposition testing in pediatric patients with CNS tumors in the United States.

Pediatric blood &amp; cancer
2023

The etiologies and management of spinal cord compression in childhood cancers: Are we aware of the emergency of cord compression?

The Turkish journal of pediatrics
2024

The specific NQO2 inhibitor, S29434, only marginally improves the survival of dopamine neurons in MPTP-intoxicated mice.

Journal of neural transmission (Vienna, Austria : 1996)
2024

Dauricine attenuates Oct4/sonic hedgehog co-activated stemness and induces reactive oxygen species-mediated mitochondrial apoptosis via AKT/β-catenin signaling in human neuroblastoma and glioblastoma stem-like cells.

Phytotherapy research : PTR
2023

Quercetin-3-O-β-d-glucuronide in the Nuciferine Leaf Polyphenol Extract Promotes Neurogenesis Involving the Upregulation of the Tropomyosin Receptor Kinase (Trk) Receptor and AKT/Phosphoinositide 3-Kinase Signaling Pathway.

Journal of agricultural and food chemistry
2023

Functional Interaction between Adenosine A2A and mGlu5 Receptors Mediates STEP Phosphatase Activation and Promotes STEP/mGlu5R Binding in Mouse Hippocampus and Neuroblastoma Cell Line.

Biomolecules
2024

Early Growth Response Gene-1 Deficiency Interrupts TGFβ1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Mice.

Neuroscience bulletin
2023

Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies.

Toxicology
2023

Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children.

Journal of neuropathology and experimental neurology
2024

Palliative care for children with central nervous system tumors: results of a Spanish multicenter study.

Clinical &amp; translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.
    Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41849381mais citado
  2. Temporal clustering of neuroblastic tumours in children and young adults from Scotland.
    Environmental health : a global access science source· 2026· PMID 41580800mais citado
  3. Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio-Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse.
    Pediatric blood &amp; cancer· 2026· PMID 41518036mais citado
  4. A functionally relevant model for interrogating brain tumor-endothelial cell interactions.
    Journal of neuroscience methods· 2026· PMID 41389895mais citado
  5. Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.
    Nature biomedical engineering· 2026· PMID 40897897mais citado
  6. Bilateral blindness from optic chiasm metastasis as the initial presentation of stage 4 neuroblastoma: A case report.
    Medicine (Baltimore)· 2026· PMID 41824866recente
  7. [Deep Learning-Based Automated Segmentation Algorithms of Brain and Vertebral Substructures for Radiotherapy in Pediatric Medulloblastoma].
    Zhongguo Yi Liao Qi Xie Za Zhi· 2026· PMID 41672616recente
  8. Tumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development.
    Dis Model Mech· 2026· PMID 41502392recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251883(Orphanet)
  2. MONDO:0003144(MONDO)
  3. GARD:20721(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q6807330(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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ORPHA:251883 · MONDO:0003144
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