Decoding genetic complexity in glycogen storage diseases: three novel variants in SLC37A4, GAA, and PHKG2 identified in an Iranian cohort.

Exploring SLC1A5 (ASCT2), SLC7A5, and SLC3A2 (LAT1) Genetic Variants in Colorectal Cancer: Implications for Prognosis and Personalized Care.

Therapeutic Efficacy of S-Allyl-L-Cysteine an Active Constituent of Aged Garlic Extract in Rat Model of Gestational Diabetes Mellitus.

Simvastatin Targets PKM2 to Alter Metabolic Reprogramming in Hepatic Stellate Cells and Mitigate Liver Fibrosis.

Hematopoietic Stem-Cell Gene Therapy for Cystinosis.

Phosphorylation-Dependent Regulation and Interactions of the Neutral Amino Acid Transporter SLC6A15: Implications for Major Depression and Neuropsychiatric Disorders.

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism.

Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression.

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency.

Transduction of Quiescent Human Hematopoietic Stem and Progenitor Cells Using Lentiviral Vectors and Virus-Like Particles.

Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome.

Targeting the Mapk13-Tcf1-Slc7a5 Axis via One-Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy.

Ampelopsin preserves glutamate homeostasis against cerebral ischemia.

L-type amino acid transporter 1 deficiency delays intestinal tissue repair in dextran sulfate sodium-induced colitis.

The glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagic Escherichia coli.

FOXM1/FUS facilitates triple-negative breast cancer malignant progression and glutamine metabolism through mediating SLC7A5 transcription.

Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity.

Cx43 phosphorylation at Ser368 facilitates PASMC dedifferentiation in nicotine-induced pulmonary arterial remodeling.

Nickel refining fumes activate glutamine metabolism via the HIF-1α/Notch pathway to drive epithelial-mesenchymal transition in Beas-2B cells.

Glutamine metabolites promote the progression of cervical cancer by inducing M2 macrophage polarization.

TMAO converts cytochrome c into a pro-apoptotic peroxidase by destabilizing the heme-Met80 ligation.

Serine metabolism in the central nervous system: advances and challenges on a conditionally essential amino acid.

Celastrol delays the progression of hepatocellular carcinoma by suppressing SLC1A5-mediated glutamine dependence.

Proteasomal activity and disease outcome in phenylketonuria patients with a structural SLC7A5 variant.

An Alternative Metabolic Pathway of Glucose Oxidation Induced by Mitochondrial Complex I Inhibition: Serinogenesis and Folate Cycling.

Food-derived chlorogenic acid prevents aortic aneurysm and dissection by nutritional restore branched-chain amino acid dyshomeostasis.

ETV1 Drives CD4+ T Cell-Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5.

SLBP promotes lung adenocarcinoma progression by inhibiting ferroptosis and reprogramming glutamine metabolism via FADS2 interaction.

Unveiling the Structure of PROT and ATB0,+: Unique Members of the Glycine Transporter Subfamily.

Disentangling the mechanistic role of loop-C capping in Cys-loop receptor activation.

A hyperexcited basolateral amygdala complex state determines the hippocampal structural plasticity associated with the reconsolidation of a fear memory.

Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.

Genetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balance.

Potential benefits of l-serine in children with GRIN2B loss-of-function variants: Randomized n-of-1 trials.

MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway.

Downregulation of the cysE/cysK genes of Clostridioides difficile induced by cysteine revealed the response of bacteria to iron homeostasis.

The Arabidopsis neutral amino acid transporter UmamiT20 confers Botrytis cinerea susceptibility.

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

Cysteine residues located within the core domain of human vitamin C transporter, hSVCT2, are essential for its structural and functional properties.

Isoliquiritigenin Inhibits Triple-Negative Breast Cancer Progression via Targeting the IRF5/SLC7A5/IDO1-Mediated Tryptophan Metabolism Pathway.

Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via NAD+ Signalling.

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut microbiota and glutamine transport via an integrative approach combining UHPLC-MS/MS and experimental verification.

TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence.

Revisiting phenylketonuria: Do high brain glycine levels caused by chronic hyperphenylalanemia contribute to brain dysfunction by modulating D-serine levels and NMDA receptor activity?

LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia.

Screening for novel L-type amino acid transporter 1 (SLC7A5) inhibitors using a fluorescent amino acid.

Non-Ser36 phosphorylated p66Shc inhibits TRPC-dependent and TRPC-independent calcium influx in vascular smooth muscle cells.

D-Serine's Journey Between Stars and Synapses.

ALDH2 deficiency aggravates vascular injury-induced restenosis by enhancing vascular smooth muscle cell proliferation through SLC38A2-mediated upregulation of glutamine uptake.

Crossing the Borders: the amino acid transporter LAT1 (SLC7A5) in the Blood-Brain Barrier.

Inhibition of integrin α3 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake.

d-serine prevents cognitive impairment in a mouse model of NMDAR encephalitis.

Identification of ShgH as a dual histidine/glutamine transporter component essential for Streptococcus suis virulence and biofilm modulation.

14-3-3θ phosphorylation at S232 reduces its interactome and regulates axonal trafficking.

Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development.

Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation.

Phenotypic variability in cystinosis: Lessons from an atypical case.

Differential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations.

Molecular determinants of cesium- and glycine-dependent glycine receptor activation.

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis.

Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis.

Deciphering the molecular mechanisms of startle disease: The role of the Asn46Lys mutation in the glycine receptor.

Reprogramming glutamine metabolism enhances BCMA-CAR T-cell fitness and therapeutic efficacy in multiple myeloma.

Mutational effects of the asparagine198 and glutamate223 residues on the human norepinephrine transporter on basal and HIV-1 Tat protein-induced inhibition of dopamine transport.

Reprogramming cysteine metabolism via METTL14-SLC7A11 axis promotes the progression of NAFLD and hepatocellular carcinoma.

Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor.

A Novel Approach for Cisplatin-Resistant Esophageal Squamous Cell Carcinoma via Amino Acid Transporter LAT1 Inhibition.

Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure.

[Ziwuliuzhu acupuncture modulates Glu/GABA‑Gln metabolic loop abnormalities in insomniac rats].

JPH203 alleviates renal fibrosis via inhibition of serine-related mTORC1 pathway in TGF-β1-induced fibroblasts and UUO mice.

Clinical exome sequencing efficacy and phenotypic expansions involving non-isolated congenital anomalies of kidney and urinary tract (CAKUT+).

Therapeutic strategies in cystinosis: A focus on cysteamine and beyond.

A Systems Biology Perspective on Childhood ADHD: Neurochemical Dysregulation, Brain-Behavior Interactions, and Emerging Therapeutics.

Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension.

Hartnup disease-causing SLC6A19 mutations lead to B0AT1 aberrant trafficking and ACE2 mis-localisation implicating the endoplasmic reticulum protein quality control.

Sequential administration of D-cycloserine and MK801 reduces pERK-expressing neurons in the lateral amygdala and disrupts threat memory reconsolidation.

Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome.

McLeod syndrome mimicking mitochondrial myopathy due to a novel in-frame duplication in the XK gene.

Adaptive cohort design and LAT1 expression scale: study protocol for a Phase 2a trial of QBS72S in breast cancer brain metastases.

Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism.

OseR, a bacterial redox sensor, regulates ergothioneine uptake via a Cys thiol switch, enhancing oxidative stress resistance and virulence.

N-methyl-d-aspartate receptor is involved in the progression of anxiety disorders with thyroid tumors.

A Proton Magnetic Resonance Spectroscopy (1H MRS) Pilot Study Revealing Altered Glutamatergic and Gamma-Aminobutyric Acid (GABA)ergic Neurotransmission in Social Anxiety Disorder (SAD).

Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1.

"Glutaminolysis Fuels Reactive Astrocytes, Exacerbating Amyloid Pathology in Alzheimer's Disease".

Adaptively increased intake of arginine sustains oral keratinocyte survival through alleviating oxidative stress during targeting glutamine metabolism.

SLC1A5-dependent glutamine uptake in hepatocytes promotes liver regeneration.

Microenvironment responsive nanoplatform for targeted removal of cholesterol and reshaping inflammatory microenvironment in atherosclerotic plaques.

The antiport mechanism of the human LAT1 transporter: defining the molecular determinants by means of wet and dry approaches.

Amino acid transporter LAT1 (SLC7A5) promotes metabolic rewiring in TNBC progression through the L-Trp/QPRT/NAD+ pathway.

A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells.

Impact of 7-ketocholesterol on the function and stability of the LAT1 transporter.

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting-Induced Proteolysis.

Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas.

SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis.

Targeting glutamine metabolism in CD4+ T-cell-mediated autoimmune diseases.

Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration.

A potential therapeutic target at Connexin 43 serine phosphorylation against ischaemia/reperfusion arrhythmia.

Mechanism of SLC1A5 Regulation of Glutamine Metabolism to Promote Ferroptosis Sensitivity in Endometriosis.

Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1.

Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.

Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia.

Role of Slc7a11 in Bleomycin-Induced Lung Injury.

Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response.

Targeting LAT1 with JPH203 to reduce TNBC proliferation and reshape suppressive immune microenvironment by blocking essential amino acid uptake.

Computational prediction of deleterious nonsynonymous SNPs in the CTNS gene: implications for cystinosis.

Long-term outcomes in nephropathic cystinosis: a review.

Molecular mechanism of thyroxine transport by monocarboxylate transporters.

Effects of energy and amino acid intake during gestation on reproductive performance, milk composition, antioxidant status and placental nutrient transport in high-parity sows.

Epigenetic Activation of PTCD3 Promotes CRC Glutamine Metabolism and Metastasis via IGF2BP2-Mediated SLC38A2 m6A Modification.

Early involvement of D-serine in β-amyloid-dependent pathophysiology.

Cx45 regulation by kinases and impact of expression in heart failure.

Structural basis of excitatory amino acid transporter 3 substrate recognition.

Group A Streptococcal asparagine metabolism regulates bacterial virulence.

An excitatory amino acid transporter 1 acts as a novel glutamine transporter and immune modulator in the oyster Crassostrea gigas.

Ectopic expression of Slc1a2 in the prefrontal cortex of sleep-deprived male mice counteracts the glutamate/GABA-glutamine dysfunction.

Novel mechanism for tubular injury in nephropathic cystinosis.

Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex.

SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders.

The Glutamate/GABA-Glutamine Cycle: Insights, Updates, and Advances.

SLC7A5/E2F1/PTBP1/PKM2 axis mediates progression and therapy effect of triple-negative breast cancer through the crosstalk of amino acid metabolism and glycolysis pathway.

Alterations of valsartan pharmacokinetics in a rodent model of metabolic dysfunction-associated steatohepatitis.

The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi.

Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions.

Serum levels of D-cycloserine predict antidepressant effects in pharmacologically enhanced intermittent theta-burst stimulation.

Synthesis of PbCrO4 nanorods-Ti3C2Tx MXene composites: A sensitive photoelectrochemical sensor for the detection of cysteine in human blood serum.

Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis.

Characterisation of SLC38A8 and Its Role in Retinal Pathways and Disease.

SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling.

Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export.

Key role of the CSE/transsulfuration pathway in macrophage phenotypic change under iron overload.

Involvement of the astroglial glutamate-glutamine cycle in the analgesic effects of electroacupuncture in a rat model of chronic neuropathic pain.

Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases.

SERINC2-mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion.

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis.

Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.

SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer.

Expression rate of LAT1 in high-grade parotid gland carcinoma and potential of BNCT as a treatment option for recurrent parotid gland carcinoma.

KNTC1 introduces segmental heterogeneity to mitochondria.

[Research progress on the mechanism of leucine regulation of protein synthesis in aging skeletal muscle through LAT1].

Contiguous Xp21 deletion involving Duchenne muscular dystrophy and McLeod neuroacanthocytosis syndrome results in rapidly progressive and fatal cardiomyopathy.

Structural Dynamics of Neutral Amino Acid Transporter SLC6A19 in Simple and Complex Lipid Bilayers.

Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance.

The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation.

Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice.

Acetylation of proximal cysteine-lysine pairs by alcohol metabolism.

Insight into the Structure of the Neutral Amino Acid Transporter B0AT2 Enabled the Discovery of Tiagabine as an Inhibitor.

Microenvironmental G protein-coupled estrogen receptor-mediated glutamine metabolic coupling between cancer-associated fibroblasts and triple-negative breast cancer cells governs tumour progression.

Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression.

LAT1 transporter as a target for breast cancer diagnosis and therapy.

[Advances in the Pathophysiology and Drug Discovery of Novel Therapeutics for Attention-Deficit/hyperactivity Disorder].

Delivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease.

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.

The therapeutic effect and underlying biochemical mechanism of methylprednisolone and D-methionine in "rescuing" noise-induced hearing loss in guinea pigs.

SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.

Effect of ceftriaxone on the glutamate-glutamine cycle and seizure susceptibility of Tg2576 mouse model of Alzheimer's disease.

The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release.

RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis.

Procognitive Effects of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation in Major Depressive Disorder: Effets procognitifs de la D-cyclosérine en traitement complémentaire par la stimulation thêta-burst intermittente dans le trouble dépressif caractérisé.

SLC7A9 suppression increases chemosensitivity by inducing ferroptosis via the inhibition of cystine transport in gastric cancer.

Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis.

Lysine 204 is crucial for the antiport function of the human LAT1 transporter.

Expression of the large amino acid transporter SLC7A5/LAT1 on immune cells is enhanced in primary sclerosing cholangitis-associated cholangiocarcinoma and correlates with poor prognosis in cholangiocarcinoma.

Constitutive sodium permeability in a C. elegans two-pore domain potassium channel.

Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation.

Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21.

Dietary glutamine supplementation improves both Th1 and Th17 responses via CARD11-mTORC1 pathway in murine model of atopic dermatitis.

Essentiality of SLC7A11-mediated nonessential amino acids in MASLD.

JPH203 alleviates peritoneal fibrosis via inhibition of amino acid-mediated mTORC1 signaling.

Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I.

The Multifaceted Role of L-Type Amino Acid Transporter 1 at the Blood-Brain Barrier: Structural Implications and Therapeutic Potential.

Clinical Features and Novel Pathogenic Variants of Chinese Patients With McLeod Syndrome and Chorea-Acanthocytosis.

The role of double heterozygotes of SLC3A1 and SLC7A9 in the prevalence of cystine stones.

TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.

ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasia.

Expanding the mutational and phenotypical spectrum of FHONDA syndrome.

L-methionine and the L-type Ca2+ channel agonist BAY K 8644 collaboratively contribute to the reduction of depressive-like behavior in mice.

Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut.

Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer.

The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney.

Therapeutic drug monitoring in Parkinson's disease.

UBAP2 contributes to radioresistance by enhancing homologous recombination through SLC27A5 ubiquitination in hepatocellular carcinoma.

Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology.

LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19).

YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner.

Digital clubbing without hypoxia for lysinuric protein intolerance.

Mitochondrial complex I promotes kidney cancer metastasis.

Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation.

Long-term effects of luteolin in a mouse model of nephropathic cystinosis.

Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles.

Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.

Hyperekplexia: A Single-Center Experience.

Exosomal miR-126-3p: Potential protection against vascular damage by regulating the SLC7A5/mTOR Signalling pathway in human umbilical vein endothelial cells.

Structural Studies of the Taurine Transporter: A Potential Biological Target from the GABA Transporter Subfamily in Cancer Therapy.

Glutamine metabolic competition drives immunosuppressive reprogramming of intratumour GPR109A+ myeloid cells to promote liver cancer progression.

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release.

Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel.

Multilayered proteomics reveals that JAM-A promotes breast cancer progression via regulation of amino acid transporter LAT1.