Introdução
O que você precisa saber de cara
A paraplegia espástica hereditária (PEH) é um grupo de doenças hereditárias cuja principal característica é um distúrbio progressivo da marcha. A doença apresenta rigidez progressiva (espasticidade) e contratura nos membros inferiores. A PEH também é conhecida como paraparesia espástica hereditária, paraplegia espástica familiar, doença do assentamento francês, doença de Strumpell, ou doença de Strumpell-Lorrain. Os sintomas são resultado da disfunção de longos axônios na medula espinhal. As células afetadas são os neurônios motores primários; portanto, a doença é uma doença do neurônio motor superior. A PEH não é uma forma de paralisia cerebral, embora fisicamente possa parecer e se comportar de forma muito semelhante à diplegia espástica.
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Paraplegia espástica hereditária pura ou complexa
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
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Copper-hydroxyl interactions drive water-promoted copper surface oxidation and mobility.
Este estudo revelou que a presença de água, especificamente seus grupos hidroxila, acelera significativamente a oxidação do cobre e aumenta a mobilidade de seus átomos na superfície, ao desorganizar a camada de cobre e facilitar a penetração do oxigênio. Para pacientes e médicos, essa descoberta é crucial para o desenvolvimento de implantes e dispositivos médicos que utilizam cobre ou suas ligas. Compreender esse mecanismo permite criar materiais mais resistentes à corrosão em ambientes úmidos do corpo, garantindo maior durabilidade e segurança.
🇧🇷 traduzidoPre-monsoon aerosol intensification and enhanced atmospheric warming over the South-Eastern Arabian Sea.
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Nature communicationsInfluence of Oxygen Partial Pressure on Sputtered NiOx Film Characteristics and Deep Interface Trap Density in NiOx/β-Ga2O3 Heterojunction Diodes.
ACS applied materials & interfacesFabrication of Electroconductive PVDF Membranes: Hierarchical Architectures for Synergistic Biofouling Suppression and Electrochemical Regeneration.
ACS applied materials & interfacesPhase Diagram of 2D Poly(Ethylene Oxide)-block-Poly(Propylene Oxide)-block-Poly(Ethylene Oxide)─Poly(Dimethylsiloxane) Blends: A Combined Neutron Reflectometry and Sum Frequency Generation Study.
Langmuir : the ACS journal of surfaces and colloidsLong-term farming and cropping systems with contrasting nitrogen forms and input diversity influence soil prokaryotic diversity in the central highlands of Kenya.
PloS oneSwertiamarin fails to induce cytotoxicity in colon cancer cell lines: Evidence against a direct anticancer effect.
PloS oneThermodynamically Consistent Enthalpies of Adsorption of Mixtures from Classical Density Functional Theory.
The journal of physical chemistry. BLow Complication Rate Following Contemporary Pure Anteriorization Tibial Tubercle Osteotomy for Patellofemoral Chondral Wear in Patients Aged Less Than 50 Years.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy AssociationTargeting TNBC: core-shell polycationic polyurea dendrimers with inherent anticancer activity.
FEBS open bioIce-rubber friction mechanisms across scales.
Soft matterThermodynamic discontinuity in evaporating thin solvated nematics.
The Journal of chemical physicsQuantum dynamics of water dissociation on a Cu/Ni(111) bimetallic alloy surface: A nine-dimensional model.
The Journal of chemical physicsImpact of Various Essential Oils or Their Pure Components on the Selected Properties and Microbicidal Potential of Chitosan-Based Coatings.
Langmuir : the ACS journal of surfaces and colloidsAsymmetric Michael Addition of 3-Chlorooxindoles with Vinylidene Bisphosphonates: Synthesis of 3,3-Disubstituted 3-Chlorooxindoles and Spirocyclopropane-Fused Oxindoles.
The Journal of organic chemistryHow Realistic Are Idealized Copper Surfaces? A Machine Learning Study of Rough Copper-Water Interfaces.
ACS materials AuZr6O4(OH)4(O2C-t-Bu)12 precursor uncovers how modulators govern supersaturation, nucleation, and growth of UiO-66 nanocrystals.
Chemical scienceResonance Raman and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) Analysis of Biological Polyenes in Shells: A Nondestructive Approach for Species and Habitat Identification.
ACS omegaResearch on Synergistic Permeability Enhancement Technology of Staged Fracturing Acidification in Low-Permeability Coal Reservoirs.
ACS omegaMussel-Inspired Strong Adhesive for Sand Fixation Based on Tannic Acid with Analysis of Adhesion Mechanisms.
ACS omegaSol-Gel Synthesis of SnO2/Zn2-SnO4 Heterostructure for the Photocatalytic Degradation of Malachite Green.
ACS omegaEnhanced Charge Separation and Visible-Light Utilization in La-Doped MIL-100(Fe) for Efficient Cr(VI) Photoreduction.
ACS omegaAntimicrobial and Photocatalytic Properties under Visible Blue LED Light of Silver Phosphate Supported on Biogenic Zeolite from Amazon Natural Source.
ACS omegaEvaluating Claudin-6 and isochromosome 12p in the progression from germ cell neoplasia in situ to primary testicular germ cell tumor and post-chemotherapy teratoma: implications for CLDN6-targeted therapies.
Therapeutic advances in medical oncologyUnderstanding strain localization in metallic materials: a review of high-resolution digital image correlation and related techniques.
Science and technology of advanced materialsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Copper-hydroxyl interactions drive water-promoted copper surface oxidation and mobility.
- Pre-monsoon aerosol intensification and enhanced atmospheric warming over the South-Eastern Arabian Sea.
- Impact of cardiometabolic criteria on the pathogenesis of MASLD and diagnostic performance of non-invasive tests.
- Synthesis of gold nanorod@Pd(Pt)-Cu2O dendritic nanocomposites for plasmon-enhanced photocatalysis.
- Thermo-Transitioning Core-Shell Microgels Combine Cohesive Reinforcement and Noncohesive Reconfigurability to Enable 3D Bioprinting and Stabilize Tissues During Incubation.
- Associations between hearing, subjective memory complaints, and dementia risk factors among audiology clients.
- Sentinel Lymph Node Biopsy for Desmoplastic Melanoma: A Systematic Review and Meta-analysis.
- Hanseniaspora uvarum and Hanseniaspora opuntiae differ in their growth and in the production of volatile organic compounds in wine.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:320335(Orphanet)
- MONDO:0017913(MONDO)
- GARD:21429(GARD (NIH))
- Q55346012(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
